Biochemical Society Transactions

Article	Citations
Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis	81
Elevator-type mechanisms of membrane transport	78
Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase	68
Towards structure-focused glycoproteomics	60
Androgens and the masculinization programming window: human–rodent differences	57
Trehalose 6-phosphate signalling and impact on crop yield	52
Structure determination of GPCRs: cryo-EM compared with X-ray crystallography	51
Tying up loose ends: the N-degron and C-degron pathways of protein degradation	50
Functional heterogeneity in senescence	50
Molecular regulation of autophagosome formation	49
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins	48
The pockets guide to HLA class I molecules	48
α-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19	46
How does methotrexate work?	45
Unleashing the therapeutic potential of apoptotic bodies	44
Regulation and functional role of the electron transport chain supercomplexes	42
Extracellular matrix stiffness and Wnt/β-catenin signaling in physiology and disease	41
Computational methods for exploring protein conformations	41
Proteasome in action: substrate degradation by the 26S proteasome	40
Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals	40
Chain reactions: molecular mechanisms of RBR ubiquitin ligases	39
Bacteria autoaggregation: how and why bacteria stick together	38
Advances in the occurrence and biotherapy of osteoporosis	38
Endothelial response to glucose: dysfunction, metabolism, and transport	38
Hydrogen peroxide reactivity and specificity in thiol-based cell signalling	37

Alternative splicing in plant abiotic stress responses	37
Intrinsically disordered proteins and membranes: a marriage of convenience for cell signalling?	37
Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications	36
Small nucleolar RNAs: continuing identification of novel members and increasing diversity of their molecular mechanisms of action	36
Inhibition of RAF dimers: it takes two to tango	36
Architectural RNA in chromatin organization	36
Transmission and prevention of SARS-CoV-2	35
Class IA PI3K regulatory subunits: p110-independent roles and structures	34
Developments in tandem ion mobility mass spectrometry	34
Mobility connects: transposable elements wire new transcriptional networks by transferring transcription factor binding motifs	33
Mammalian GPI-anchor modifications and the enzymes involved	32
Parkinson's disease and mitophagy: an emerging role for LRRK2	31
Gut microbiota and metabolites in the pathogenesis of endocrine disease	31
Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins	30
Big data and artificial intelligence (AI) methodologies for computer-aided drug design (CADD)	30
Promiscuity and specificity of eukaryotic glycosyltransferases	30
Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review	30
Mechanisms of mitochondrial cell death	30
Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studies	29
CRISPR-based gene expression control for synthetic gene circuits	29
Cross-talk between redox signalling and protein aggregation	29
Aneuploidy in human eggs: contributions of the meiotic spindle	29
ERK1/2 in immune signalling	28
Decellularized bone extracellular matrix in skeletal tissue engineering	28
Nuclear import of histones	28
Current problems and future avenues in proteoliposome research	28
Materno-fetal cholesterol transport during pregnancy	28
The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction	28
Synthetic biology approaches towards the recycling of metals from the environment	27
Leloir glycosyltransferases of natural product C-glycosylation: structure, mechanism and specificity	27
Nicotinamide adenine dinucleotide (NAD+): essential redox metabolite, co-substrate and an anti-cancer and anti-ageing therapeutic target	27
Inhibitors in AKTion: ATP-competitive vs allosteric	27
The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape	27
The role of SUMOylation during development	27
Improving photosynthesis through the enhancement of Rubisco carboxylation capacity	27
Does it take two to tango? RING domain self-association and activity in TRIM E3 ubiquitin ligases	27
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases	26
New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease	26
Advances in modelling the human microbiome–gut–brain axis in vitro	25
Activation of STAT transcription factors by the Rho-family GTPases	25
The road to the structure of the mitochondrial respiratory chain supercomplex	25
The Hitchhiker's guide to glycoproteomics	25
Systems approach to rational combination therapy: PARP inhibitors	25
Antivirals that target the host IMPα/β1-virus interface	24
Engineering with NanoLuc: a playground for the development of bioluminescent protein switches and sensors	24
Progress in the therapeutic inhibition of Cdc42 signalling	24
Sequence determinants, function, and evolution of CpG islands	24
The effect of Irisin on bone cells in vivo and in vitro	24
The development of proteinase-activated receptor-2 modulators and the challenges involved	24
The role of lactobacilli in inhibiting skin pathogens	23

The mitochondrial ADP/ATP carrier exists and functions as a monomer	23
Smc5/6, an atypical SMC complex with two RING-type subunits	23
The needle and the haystack: single molecule tracking to probe the transcription factor search in eukaryotes	23
Targeting MmpL3 for anti-tuberculosis drug development	23
The tryptophan biosynthetic pathway is essential forMycobacterium tuberculosisto cause disease	23
How neural stem cells contribute to neocortex development	22
The evolution of multicellularity and cancer: views and paradigms	22
Pore-forming toxins in infection and immunity	22
Gene transcription and chromatin regulation in hypoxia	22
The impact of photorespiration on plant primary metabolism through metabolic and redox regulation	22
Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells	22
Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators	22
The role of caspases as executioners of apoptosis	22
Transcriptome view of a killer: African swine fever virus	22
Organ-on-chip applications in drug discovery: an end user perspective	22
Emerging mass spectrometry-based proteomics methodologies for novel biomedical applications	21
Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for…	21
S-acylation in plants: an expanding field	21
Plant transporters involved in combating boron toxicity: beyond 3D structures	21
VDAC2 and the BCL-2 family of proteins	21
Therapeutic targeting of mitophagy in Parkinson's disease	20
Function and regulation of corin in physiology and disease	20
Engineering pattern formation and morphogenesis	20
Role of the adaptive immune system in atherosclerosis	20
The molecular basis of plant cellulose synthase complex organisation and assembly	19
Latest update on chemokine receptors as therapeutic targets	19
Detergent-free systems for structural studies of membrane proteins	19
Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance	19
Recent developments in sustainably sourced protein-based biomaterials	18
How do histone modifications contribute to transgenerational epigenetic inheritance in C. elegans?	18
IMPDH dysregulation in disease: a mini review	18
Solar-driven water-splitting provides a solution to the energy problem underpinning climate change	18
MicroRNAs and long non-coding RNAs as novel regulators of ribosome biogenesis	18
From diagnosis to therapy in Duchenne muscular dystrophy	18
Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease	18
The evolutionary dynamics of venom toxins made by insects and other animals	17
Combinatorial biosynthesis for the generation of new-to-nature peptide antimicrobials	17
Fluorescent proteins for in vivo imaging, where's the biliverdin?	17
Exploring the multifunctionality of SR proteins	17
Not just a writer: PRC2 as a chromatin reader	17
Fuzzy protein theory for disordered proteins	17
Structural insights into glucocorticoid receptor function	17
Galectin-8, cytokines, and the storm	17
Methods for protein delivery into cells: from current approaches to future perspectives	17
The functional importance of VCP to maintaining cellular protein homeostasis	17
Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms	17
Emerging roles of adhesion G protein-coupled receptors	17
GCN2: roles in tumour development and progression	17
Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity	17
The emerging complexity of PDGFRs: activation, internalization and signal attenuation	17
Molecular genetics of renal ciliopathies	16
The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines	16
Host ADP-ribosylation and the SARS-CoV-2 macrodomain	16
Bile acid metabolism and FXR-mediated effects in human cholestatic liver disorders	16
Protein-fragment complementation assays for large-scale analysis of protein–protein interactions	16
Organ-on-a-chip: current gaps and future directions	16
Aberrant protein glycosylation in cancer: implications in targeted therapy	16
Unlocking immune-mediated disease mechanisms with transcriptomics	16
Varicella-zoster virus: molecular controls of cell fusion-dependent pathogenesis	16
Type 2 immunity in intestinal homeostasis and inflammatory bowel disease	16
Role of macrophage extracellular traps in innate immunity and inflammatory disease	16
What defines the maternal transcriptome?	16
Extracellular vesicles and the extracellular matrix: a new paradigm or old news?	16
Serpins in cartilage and osteoarthritis: what do we know?	15
Controlling gene expression with light: a multidisciplinary endeavour	15
GPX4: old lessons, new features	15
Functional interrogation and therapeutic targeting of protein tyrosine phosphatases	15
Emerging aspects in the regulation of ferroptosis	15
Biomolecular complex viewed by dynamic nuclear polarization solid-state NMR spectroscopy	15
Methods for the solubilisation of membrane proteins: the micelle-aneous world of membrane protein solubilisation	15
Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking	15
Inhibition of RAS: proven and potential vulnerabilities	15
RNA transfer through tunneling nanotubes	15
Interferon-induced GTPases orchestrate host cell-autonomous defence against bacterial pathogens	14
A review of methods for the reconstruction and analysis of integrated genome-scale models of metabolism and regulation	14
How activated NLRs induce anti-microbial defenses in plants	14
Relationship between mucosa-associated gut microbiota and human diseases	14
Structure and evolution of the bifidobacterial carbohydrate metabolism proteins and enzymes	14
Caught in the act: structural dynamics of replication origin activation and fork progression	14
Full-length galectin-8 and separate carbohydrate recognition domains: the whole is greater than the sum of its parts?	14

HTR6 and SSTR3 targeting to primary cilia	14
Molecular and structural aspects of gasdermin family pores and insights into gasdermin-elicited programmed cell death	14
The diverse arsenal of type III CRISPR–Cas-associated CARF and SAVED effectors	14
Applications of Cryo-EM in small molecule and biologics drug design	14
Daylight-PDT: everything under the sun	14
Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance	14
Identifying key regulators of the intestinal stem cell niche	14
Biological insights from SMA-extracted proteins	14
Molecular subversion of Cdc42 signalling in cancer	14
Condensin complexes: understanding loop extrusion one conformational change at a time	14
The expanding world of metabolic enzymes moonlighting as RNA binding proteins	14
Circadian rhythm of lipid metabolism	14
Drug repurposing in silico screening platforms	14
Structural dynamics of ABC transporters: molecular simulation studies	14
Translational control in cell ageing: an update	14
The structural biology of canonical Wnt signalling	14
Targeting the DNA damage response for cancer therapy	14
The complex, bidirectional role of extracellular vesicles in infection	14
HSP90 as a regulator of extracellular matrix dynamics	13
TOP2B's contributions to transcription	13
CHCHD4 (MIA40) and the mitochondrial disulfide relay system	13
The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities	13
AAA+ proteins: one motor, multiple ways to work	13
Biofilm and swarming emergent behaviours controlled through the aid of biophysical understanding and tools	13
An integrated view of innate immune mechanisms in C. elegans	13
DNA methylation: from model plants to vegetable crops	13
Monolysocardiolipin (MLCL) interactions with mitochondrial membrane proteins	13
Using computational modelling to reveal mechanisms of epigenetic Polycomb control	13
Rotor subunits adaptations in ATP synthases from photosynthetic organisms	13
New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics	13
LRRK2 along the Golgi and lysosome connection: a jamming situation	13
Understanding the immune responses involved in mediating protection or immunopathology during leishmaniasis	13
CDKL5 deficiency disorder: molecular insights and mechanisms of pathogenicity to fast-track therapeutic development	13
Relating SMCHD1 structure to its function in epigenetic silencing	13
Three-dimensional models of the lung: past, present and future: a mini review	13
Microglia extracellular vesicles: focus on molecular composition and biological function	13
Promotion of cancer cell stemness by Ras	13
Mechanistic insights into KDM4A driven genomic instability	13
OFD Type I syndrome: lessons learned from a rare ciliopathy	13
ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control	13
Effects of carboxyl-terminal methylation on holoenzyme function of the PP2A subfamily	13
Plant derived cyclic peptides	13
Great balls of fire: activation and signalling of inflammatory caspases	13
Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens	13
Programmed DNA elimination: silencing genes and repetitive sequences in somatic cells	12
Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity	12
Towards the routine use of in silico screenings for drug discovery using metabolic modelling	12
Viscoelastic properties of epithelial cells	12
‘PIPs’ in DNA polymerase: PCNA interaction affairs	12
From protocells to prototissues: a materials chemistry approach	12
To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation	12
Driving antimalarial design through understanding of target mechanism	12
Lipid–protein interactions in virus assembly and budding from the host cell plasma membrane	12
Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation	12
Nutrient regulation of the flow of genetic information by O-GlcNAcylation	12
ISG15 driven cellular responses to virus infection	12
The role of the blood–brain barrier during neurological disease and infection	12
Tall tails: cryo-electron microscopy of phage tail DNA ejection conduits	12
The role of RHIM in necroptosis	12
ER functions are exploited by viruses to support distinct stages of their life cycle	12
It's not just a phase; ubiquitination in cytosolic protein quality control	12