Biochemical Society Transactions

Article	Citations
Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling	82
Illuminating membrane structural dynamics of fusion and endocytosis with advanced light imaging techniques	80
Structural insights into ferroportin mediated iron transport	79
Do tunneling nanotubes drive chemoresistance in solid tumors and other malignancies?	70
Transgenic mouse models to study the physiological and pathophysiological roles of human Siglecs	68
CD95/Fas ligand induced toxicity	66
Advances in understanding telomerase assembly	65
Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance	64
Negative regulation of biofilm formation by nitric oxide sensing proteins	57
Inflammatory cell death: how macrophages sense neighbouring cell infection and damage	57
Stop CRYing! Inhibition of cryptochrome function by small proteins	50
Organ-on-chip applications in drug discovery: an end user perspective	50
Chemical catalysis by biological amyloids	45
The impact of amino acid metabolism on adult neurogenesis	43
A guide into the world of high-resolution 3D imaging: the case of soft X-ray tomography for the life sciences	43
The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer	42
Neurodevelopmental functions of CHD8: new insights and questions	41
Understanding immune signaling using advanced imaging techniques	39
Caveolae and the oxidative stress response	38
Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation	36
Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation	36
Exploring the multifunctionality of SR proteins	36
Reconstituting membrane fission using a high content and throughput assay	35
Maximizing the performance of protein-based fluorescent biosensors	35
The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI	32

Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions	32
LARP6 proteins in plants	32
Alpha-to-beta cell trans-differentiation for treatment of diabetes	32
Big data and artificial intelligence (AI) methodologies for computer-aided drug design (CADD)	31
Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease	31
The molecular mechanisms of diapause and diapause-like reversible arrest	31
Aminoacyl-tRNA synthetase interactions in SARS-CoV-2 infection	30
A dynamic role for transcription factors in restoring transcription through mitosis	30
The role of protein acetylation in regulating mitochondrial fusion and fission	30
The role of autophagy-lysosomal pathway in motor neuron diseases	29
Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?	29
Writing and erasing O-GlcNAc from target proteins in cells	29
Compatibility of termination mechanisms in bacterial transcription with inference on eukaryotic models	29
Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics	29
Experimental systems for the analysis of mutational signatures: no ‘one-size-fits-all' solution	29
Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity	28
The role of RHIM in necroptosis	28
Structural switching of tubulin in the microtubule lattice	28
Applications of Cryo-EM in small molecule and biologics drug design	28
Deconstructing cancer with precision genome editing	28
The role of lipid scramblases in regulating lipid distributions at cellular membranes	28
Exploring potential developmental origins of common neurodegenerative disorders	27
Ribosomal RNA expansion segments and their role in ribosome biology	27
Correction: Current Working Models of SMC-driven DNA-loop extrusion	27
Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria	27
Last but not least: BFL-1 as an emerging target for anti-cancer therapies	27
Spo11: from topoisomerase VI to meiotic recombination initiator	27
New insights into the structure and dynamics of the TOM complex in mitochondria	27
Microglia extracellular vesicles: focus on molecular composition and biological function	27
The SMN-ribosome interplay: a new opportunity for Spinal Muscular Atrophy therapies	26
Conquer by cryo-EM without physically dividing	26
Periodic pattern formation during embryonic development	25
The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder	25
Transition from totipotency to pluripotency in mice: insights into molecular mechanisms	25
The long and the short of Periscope Proteins	25
Are cachexia-associated tumors transmitTERS of ER stress?	25
Encyclopaedia of eukaryotic DNA methylation: from patterns to mechanisms and functions	25
Proteolytic regulation of mitochondrial oxidative phosphorylation components in plants	25
Structural glycobiology – from enzymes to organelles	24
Studying membrane proteins with MicroED	24
The evolution and structure/function of bHLH–PAS transcription factor family	24
Efficiency and equity in origin licensing to ensure complete DNA replication	24
Ceramide microdomains: the major influencers of the sphingolipid media platform	23
Unravelling the structural complexity of protein–lipid interactions with neutron reflectometry	23
S-acylation in apoptotic and non-apoptotic cell death: a central regulator of membrane dynamics and protein function	23
Three-dimensional models of the lung: past, present and future: a mini review	22
Frankenstein Cas9: engineering improved gene editing systems	22
CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact	22
Expect the unexpected: conventional and unconventional roles for cadherins in collective cell migration	22
MsbA: an ABC transporter paradigm	22

DNA methylation: from model plants to vegetable crops	21
Recent insights into the control of mitochondrial fission	21
Small regulatory RNAs in rice epigenetic regulation	21
Cryo-electron tomography: en route to the molecular anatomy of organisms and tissues	21
The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis	20
GCN2: roles in tumour development and progression	20
Molecular regulation of autophagosome formation	20
The octadecanoids: an emerging class of lipid mediators	20
The role of peroxidasin in solid cancer progression	20
Exploring cryo-electron microscopy with molecular dynamics	20
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases	20
Detergent-free systems for structural studies of membrane proteins	20
How neural stem cells contribute to neocortex development	20
Bile acid metabolism and FXR-mediated effects in human cholestatic liver disorders	20
Tetraspanins affect membrane structures and the trafficking of molecular partners: what impact on extracellular vesicles?	20
Chemical biology approaches to study histone interactors	20
General strategies for using amino acid sequence data to guide biochemical investigation of protein function	19
Novel roles for G protein-coupled receptor kinases in cardiac injury and repair	19
How lipids affect the energetics of co-translational alpha helical membrane protein folding	19
Uncovering novel regulators of memory using C. elegans genetic and genomic analysis	19
Covalent activity-based probes for imaging of serine proteases	19
Inferiority complex: why do sensory ion channels multimerize?	19
Voltage-clamp fluorometry for advancing mechanistic understanding of ion channel mechanisms with a focus on acid-sensing ion channels	19
The mechanisms of alkali therapy in targeting renal diseases	19
Methodology to detect oxidised phospholipids and their relevance in disease	18
DDX41: exploring the roles of a versatile helicase	18
Mre11–Rad50: the DNA end game	18
Research progress of ZIC5 for tumor metastasis	18
The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancer	18
Ion channels as convergence points in the pathology of pulmonary arterial hypertension	18
Structural basis of molecular recognition among classical cadherins mediating cell adhesion	18
Correction: Fast-forward on P-type ATPases: recent advances on structure and function	18
Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein	18
Role of SWI/SNF chromatin remodeling genes in lung cancer development	18
IMPDH dysregulation in disease: a mini review	17
Organismal and cellular interactions in vertebrate–alga symbioses	17
Biological insights from SMA-extracted proteins	17
PIDD1 in cell cycle control, sterile inflammation and cell death	17
Structural insights into the membrane-bound proteolytic machinery of bacterial protein quality control	17
Sculpting with stiffness: rigidity as a regulator of morphogenesis	17
The central role of translation elongation in response to stress	17
The role of caspases as executioners of apoptosis	16
Correction: Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity	16
Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury	16
Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD	16
Folding speeds of helical membrane proteins	16
Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery	16
Improving photosynthesis through the enhancement of Rubisco carboxylation capacity	16
The influence of high-order chromatin state in the regulation of stem cell fate	16
Transcriptional control of neural stem cell activity	16
Understanding the role of ten-eleven translocation family proteins in kidney diseases	16
AAA+ proteins: one motor, multiple ways to work	16
How does the tubulin code facilitate directed cell migration?	16
Shaping epithelial lumina under pressure	16
Transcriptional bursting: from fundamentals to novel insights	16
The role of pro-domains in human growth factors and cytokines	16
Non-canonical roles of ATG8 for TFEB activation	15
The role of post-translational modifications in synaptic AMPA receptor activity	15
S-acylation of Ca2+ transport proteins: molecular basis and functional consequences	15
Exploring the structural dynamics of the vesicle priming machinery	15
Artificial protein assemblies with well-defined supramolecular protein nanostructures	15
Plant supercomplex I + III2 structure and function: implications for the growing field	15
Structural and functional approaches to studying cAMP regulation of HCN channels	15
Age-dependent regenerative mechanisms in the brain	14
Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation	14
Unusual modes of cell and nuclear divisions characterise Drosophila development	14
The application of single-molecule optical tweezers to study disease-related structural dynamics in RNA	14
Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy	14
Chlamydia trachomatis invasion: a duet of effectors	14
Gone with the Wnt(less): a mechanistic perspective on the journey of Wnt	14
Molecular and structural perspectives on protein trafficking to the primary cilium membrane	14
U7 deciphered: the mechanism that forms the unusual 3′ end of metazoan replication-dependent histone mRNAs	14
Suppression of double-stranded RNA sensing in cancer: molecular mechanisms and therapeutic potential	14
LRRK2 along the Golgi and lysosome connection: a jamming situation	14
Revealing chromatin-specific functions of histone deacylases	14
Genome organization across scales: mechanistic insights from in vitro reconstitution studies	14
Organ-on-a-chip: current gaps and future directions	14
Solid state NMR of membrane proteins: methods and applications	13
How do spherical bacteria regulate cell division?	13
An update on the role of sex hormones in the function of the cardiorenal mitochondria	13

Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals	13
Regulation of the generation of reactive oxygen species during photosynthetic electron transport	13
Human E3 ubiquitin ligases: accelerators and brakes for SARS-CoV-2 infection	13
Lessons from natural molecular glue degraders	13
The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections	13
Understanding pyrethrin biosynthesis: toward and beyond natural pesticide overproduction	13
Satellite cell dynamics during skeletal muscle hypertrophy	13
Cell-free genomics: transcription factor interactions in reconstituted naïve embryonic chromatin	13
Mechanisms of epithelial growth and development in the zebrafish intestine	12
Lipid–protein interactions in virus assembly and budding from the host cell plasma membrane	12
A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway	12
Intersectin — many facets of a scaffold protein	12
Computational approaches to understand transcription regulation in development	12
The interplay of helminthic neuropeptides and proteases in parasite survival and host immunomodulation	12
The emerging theme of 3′UTR mRNA isoform regulation in reprogramming of cell metabolism	12
Bioengineering silk into blood vessels	12
Timely symbiosis: circadian control of legume-rhizobia symbiosis	12
GPX4: old lessons, new features	12
Specific isotopic labelling and reverse labelling for protein NMR spectroscopy: using metabolic precursors in sample preparation	12
Studying histone inheritance in different systems using imaging-based methods and perspectives	12
Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers	12
The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation	12
Nano-organization of synaptic calcium signaling	12
Eliminating oncogenic RAS: back to the future at the drawing board	12
Regulation of mTORC1 by the Rag GTPases	12
Bacterial microcompartments as a next-generation metabolic engineering tool: utilizing nature's solution for confining challenging catabolic pathways	12
Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology	12
Polycomb-mediated histone modifications and gene regulation	12
Npt2a as a target for treating hyperphosphatemia	12
One genome, multiple phenotypes: decoding the evolution and mechanisms of environmentally induced developmental plasticity in insects	12
How far can omics go in unveiling the mechanisms of floral senescence?	12
Targeting NRF2 to promote epithelial repair	12
The molecular mechanisms driving Plasmodium cell division	11
Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens	11
The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape	11
Recent advances in understanding the role of extracellular vesicles from probiotics in intestinal immunity signaling	11
SUMO and the DNA damage response	11
Enhancer target prediction: state-of-the-art approaches and future prospects	11
Advances in utilizing reverse micelles to investigate membrane proteins	11
Nesprin-1: novel regulator of striated muscle nuclear positioning and mechanotransduction	11
Effects of antibiotics on bacterial cell morphology and their physiological origins	11
Striving for sustainable biosynthesis: discovery, diversification, and production of antimicrobial drugs in Escherichia coli	11
The remodeling of Z-DNA in the mammalian germ line	11
The molecular mechanisms of human separase regulation	11
Microbial pathways for advanced biofuel production	11
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins	11
Mechanisms of catalytic RNA molecules	11
Current working models of SMC-driven DNA-loop extrusion	11
Unravelling mechanisms that govern meiotic crossover formation in wheat	11
Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesis	11
To export, or not to export: how nuclear export factor variants resolve Piwi's dilemma	11
Differential functions of the KRAS splice variants	10
Mapping lipid pathways during phagocytosis	10
Directed evolution approaches for optogenetic tool development	10
Current understanding of heparanase 2 regulation, a non-heparanase	10
Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA	10
Effectors and effects of arginine methylation	10
Deubiquitinases in muscle physiology and disorders	10
NLR immune receptors: structure and function in plant disease resistance	10
Cofactor F420, an emerging redox power in biosynthesis of secondary metabolites	10
Viral subversion of the cell polarity regulator Scribble	10
Quaternary arrangements of membrane proteins: an aquaporin case	10
Modification of extracellular matrix proteins by oxidants and electrophiles	10
Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin	10
Strength in numbers: effect of protein crowding on the shape of cell membranes	10
CRISPRi: a way to integrate iPSC-derived neuronal models	10
Atomic force microscopy 3D structural reconstruction of individual particles in the study of amyloid protein assemblies	10
Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion	10
Correction: Exploring the influence of anionic lipids in the host cell membrane on viral fusion	10
Scaffolds and the scaffolding domain: an alternative paradigm for caveolin-1 signaling	9
The cellular dynamics of neural tube formation	9
Exploring microRNAs in craniofacial regenerative medicine	9
Integration of functional genomics data to uncover cell type-specific pathways affected in Parkinson's disease	9
Structural insights into glucocorticoid receptor function	9
Beyond expectations: the development and biological activity of cytokinin oxidase/dehydrogenase inhibitors	9
Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions	9
Dopamine synthesis and transport: current and novel therapeutics for parkinsonisms	9
The role of PQBP1 in neural development and function	9
The NMDAR-BK channelosomes as regulators of synaptic plasticity	9
Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation	9
A multi-dimensional view of context-dependent G protein-coupled receptor function	9
Epigenetic mechanisms in paediatric brain tumours: regulators lose control	9
Computational methods to study enveloped viral entry	9
Engineering CRISPR guide RNAs for programmable RNA sensors	9
Emerging roles of adhesion G protein-coupled receptors	9
New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease	9
Advances in nanobody multimerization and multispecificity: from in vivo assembly to in vitro production	9
Beyond the mono-nucleosome	9
Role of macronutrient intake in the epigenetics of obesity	9
Phase separation and viral factories: unveiling the physical processes supporting RNA packaging in dsRNA viruses	9
Computational exploration of cellular communication in skin from emerging single-cell and spatial transcriptomic data	9
Mechanistic insights into protein folding by the eukaryotic chaperonin complex CCT	9
Interactions between zinc and NRF2 in vascular redox signalling	9
Regulation of cardiomyocyte intracellular trafficking and signal transduction by protein palmitoylation	9
Decoding the sorghum methylome: understanding epigenetic contributions to agronomic traits	9