Biochemical Society Transactions

Article	Citations
Towards structure-focused glycoproteomics	65
Structure determination of GPCRs: cryo-EM compared with X-ray crystallography	61
The pockets guide to HLA class I molecules	59
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins	57
Molecular regulation of autophagosome formation	55
Inhibition of RAF dimers: it takes two to tango	55
Endothelial response to glucose: dysfunction, metabolism, and transport	54
Regulation and functional role of the electron transport chain supercomplexes	54
ERK1/2 in immune signalling	52
Bacteria autoaggregation: how and why bacteria stick together	51
Proteasome in action: substrate degradation by the 26S proteasome	50
Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals	48
Intrinsically disordered proteins and membranes: a marriage of convenience for cell signalling?	45
Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications	41
New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease	39
Developments in tandem ion mobility mass spectrometry	37
Parkinson's disease and mitophagy: an emerging role for LRRK2	37
Mechanisms of mitochondrial cell death	37
Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studies	37
Aneuploidy in human eggs: contributions of the meiotic spindle	37
Does it take two to tango? RING domain self-association and activity in TRIM E3 ubiquitin ligases	35
Big data and artificial intelligence (AI) methodologies for computer-aided drug design (CADD)	35
Improving photosynthesis through the enhancement of Rubisco carboxylation capacity	34
The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction	34
The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape	33

The Hitchhiker's guide to glycoproteomics	32
Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review	31
The role of lactobacilli in inhibiting skin pathogens	31
Advances in modelling the human microbiome–gut–brain axis in vitro	31
Nuclear import of histones	30
Progress in the therapeutic inhibition of Cdc42 signalling	30
Sequence determinants, function, and evolution of CpG islands	30
The needle and the haystack: single molecule tracking to probe the transcription factor search in eukaryotes	29
VDAC2 and the BCL-2 family of proteins	29
The effect of Irisin on bone cells in vivo and in vitro	29
Engineering with NanoLuc: a playground for the development of bioluminescent protein switches and sensors	29
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases	29
Pore-forming toxins in infection and immunity	29
Relationship between mucosa-associated gut microbiota and human diseases	28
Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells	28
Latest update on chemokine receptors as therapeutic targets	27
Exploring the multifunctionality of SR proteins	27
The impact of photorespiration on plant primary metabolism through metabolic and redox regulation	27
Organ-on-chip applications in drug discovery: an end user perspective	26
Galectin-8, cytokines, and the storm	26
The development of proteinase-activated receptor-2 modulators and the challenges involved	26
Bile acid metabolism and FXR-mediated effects in human cholestatic liver disorders	26
Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease	25
How neural stem cells contribute to neocortex development	24
Recent developments in sustainably sourced protein-based biomaterials	24
GCN2: roles in tumour development and progression	24
The molecular basis of plant cellulose synthase complex organisation and assembly	24
Role of macrophage extracellular traps in innate immunity and inflammatory disease	24
Insulin signalling and GLUT4 trafficking in insulin resistance	24
Antivirals that target the host IMPα/β1-virus interface	24
Therapeutic targeting of mitophagy in Parkinson's disease	24
Fuzzy protein theory for disordered proteins	24
IMPDH dysregulation in disease: a mini review	24
Emerging roles of adhesion G protein-coupled receptors	23
Identifying key regulators of the intestinal stem cell niche	23
The role of caspases as executioners of apoptosis	23
Structural insights into glucocorticoid receptor function	22
RNA transfer through tunneling nanotubes	22
The functional importance of VCP to maintaining cellular protein homeostasis	22
Detergent-free systems for structural studies of membrane proteins	22
GPX4: old lessons, new features	22
Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance	22
Organ-on-a-chip: current gaps and future directions	22
CDKL5 deficiency disorder: molecular insights and mechanisms of pathogenicity to fast-track therapeutic development	21
AAA+ proteins: one motor, multiple ways to work	21
The diverse arsenal of type III CRISPR–Cas-associated CARF and SAVED effectors	21
The dynamic balance of the skin microbiome across the lifespan	20
Serpins in cartilage and osteoarthritis: what do we know?	20
Circadian rhythm of lipid metabolism	20
The role of the blood–brain barrier during neurological disease and infection	20

Not just a writer: PRC2 as a chromatin reader	20
From protocells to prototissues: a materials chemistry approach	19
Lipid–protein interactions in virus assembly and budding from the host cell plasma membrane	19
Structure and evolution of the bifidobacterial carbohydrate metabolism proteins and enzymes	19
Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms	19
What defines the maternal transcriptome?	19
Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity	19
Combinatorial biosynthesis for the generation of new-to-nature peptide antimicrobials	19
Molecular subversion of Cdc42 signalling in cancer	19
The role of RHIM in necroptosis	19
Aberrant protein glycosylation in cancer: implications in targeted therapy	18
Solar-driven water-splitting provides a solution to the energy problem underpinning climate change	18
ISG15 driven cellular responses to virus infection	18
Promotion of cancer cell stemness by Ras	18
ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control	18
Fluorescent proteins for in vivo imaging, where's the biliverdin?	18
Single-molecule tracking (SMT): a window into live-cell transcription biochemistry	18
The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities	18
Functional interrogation and therapeutic targeting of protein tyrosine phosphatases	18
Unlocking immune-mediated disease mechanisms with transcriptomics	18
Type 2 immunity in intestinal homeostasis and inflammatory bowel disease	18
Protein-fragment complementation assays for large-scale analysis of protein–protein interactions	17
HSP90 as a regulator of extracellular matrix dynamics	17
Methods for the solubilisation of membrane proteins: the micelle-aneous world of membrane protein solubilisation	17
Mechanistic insights into KDM4A driven genomic instability	17
Targeting the DNA damage response for cancer therapy	17
Microglia extracellular vesicles: focus on molecular composition and biological function	17
Applications of Cryo-EM in small molecule and biologics drug design	17
The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer	17
TOP2B's contributions to transcription	17
To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation	17
The expanding world of metabolic enzymes moonlighting as RNA binding proteins	17
Molecular genetics of renal ciliopathies	17
Drug repurposing in silico screening platforms	17
Translational control in cell ageing: an update	17
Host ADP-ribosylation and the SARS-CoV-2 macrodomain	17
New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics	16
Epigenetic regulation of human non-coding RNA gene transcription	16
Recent advances in membrane mimetics for membrane protein research	16
Therapeutic targeting of TRAIL death receptors	16
Regulation of the generation of reactive oxygen species during photosynthetic electron transport	16
CHCHD4 (MIA40) and the mitochondrial disulfide relay system	16
Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders	16
Isocitrate dehydrogenase gene variants in cancer and their clinical significance	16
Varicella-zoster virus: molecular controls of cell fusion-dependent pathogenesis	16
Structural dynamics of ABC transporters: molecular simulation studies	16
The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines	16
Rotor subunits adaptations in ATP synthases from photosynthetic organisms	16
Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking	16
Molecular and structural aspects of gasdermin family pores and insights into gasdermin-elicited programmed cell death	16
How activated NLRs induce anti-microbial defenses in plants	16
Daylight-PDT: everything under the sun	16
Three-dimensional models of the lung: past, present and future: a mini review	15
The complex, bidirectional role of extracellular vesicles in infection	15
Evolution and diversification of the nuclear pore complex	15
LRRK2 along the Golgi and lysosome connection: a jamming situation	15
Understanding the immune responses involved in mediating protection or immunopathology during leishmaniasis	15
PIDD1 in cell cycle control, sterile inflammation and cell death	15
Improving the hole picture: towards a consensus on the mechanism of nuclear transport	15
Plant derived cyclic peptides	15
Tall tails: cryo-electron microscopy of phage tail DNA ejection conduits	15
Glycoengineering Chinese hamster ovary cells: a short history	15
State of the structure address on MET receptor activation by HGF	15
The molecular pathogenesis of repeat expansion diseases	15
Interferon-induced GTPases orchestrate host cell-autonomous defence against bacterial pathogens	15
An integrated view of innate immune mechanisms in C. elegans	15
Eliminating oncogenic RAS: back to the future at the drawing board	15
Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance	15
‘PIPs’ in DNA polymerase: PCNA interaction affairs	15
HTR6 and SSTR3 targeting to primary cilia	15
DNA methylation: from model plants to vegetable crops	15
The complexity of PRC2 catalysts CLF and SWN in plants	14
Programmed DNA elimination: silencing genes and repetitive sequences in somatic cells	14
Engineered cell-laden alginate microparticles for 3D culture	14
Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation	14
Multifunctionality of F-rich nucleoporins	14
Biological insights from SMA-extracted proteins	14
Activities and binding partners of E3 ubiquitin ligase DTX3L and its roles in cancer	14
Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 proteases	14
Mitochondrial DNA as inflammatory DAMP: a warning of an aging immune system?	14

Cytoophidia and filaments: you must unlearn what you have learned	14
It's not just a phase; ubiquitination in cytosolic protein quality control	14
The octadecanoids: an emerging class of lipid mediators	14
Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens	14
Using computational modelling to reveal mechanisms of epigenetic Polycomb control	14
Viscoelastic properties of epithelial cells	14
Exploring cryo-electron microscopy with molecular dynamics	13
Effects of antibiotics on bacterial cell morphology and their physiological origins	13
cGAS–STING signalling in cancer: striking a balance with chromosomal instability	13
Nutrient regulation of the flow of genetic information by O-GlcNAcylation	13
Tumour invasion and dissemination	13
The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation	13
Great balls of fire: activation and signalling of inflammatory caspases	13
The surprising structural and mechanistic dichotomy of membrane-associated phosphoglycosyl transferases	13
Beyond the TCA cycle: new insights into mitochondrial calcium regulation of oxidative phosphorylation	13
Exploring chromatin structural roles of non-coding RNAs at imprinted domains	13
Interactions between amyloid, amyloid precursor protein, and mitochondria	13
The emerging roles of semaphorin4D/CD100 in immunological diseases	13
Cellular feedback dynamics and multilevel regulation driven by the hippo pathway	13
Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers	13
Biofilm and swarming emergent behaviours controlled through the aid of biophysical understanding and tools	13
Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments	13
Mechanism of action of nucleotide excision repair machinery	13
Mitochondrial DNA in cell death and inflammation	12
Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface	12
MsbA: an ABC transporter paradigm	12
Microbial pathways for advanced biofuel production	12
Collagen hydroxylysine glycosylation: non-conventional substrates for atypical glycosyltransferase enzymes	12
Challenges and approaches to studying pore-forming proteins	12
Photosynthetic acclimation to changing environments	12
Structural biology of human telomerase: progress and prospects	12
Glycosome heterogeneity in kinetoplastids	12
Dissecting the complexity of biomolecular condensates	12
The molecular mechanisms of diapause and diapause-like reversible arrest	12
Computational exploration of cellular communication in skin from emerging single-cell and spatial transcriptomic data	12
Serological antibody testing in the COVID-19 pandemic: their molecular basis and applications	12
Regulation of MST complexes and activity via SARAH domain modifications	12
The regulation of meiotic crossover distribution: a coarse solution to a century-old mystery?	12
Alpha-to-beta cell trans-differentiation for treatment of diabetes	12
Mre11–Rad50: the DNA end game	11
Functional diversity in the RAS subfamily of small GTPases	11
Last but not least: BFL-1 as an emerging target for anti-cancer therapies	11
Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics	11
Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy	11
Defining the physiological determinants of low nitrogen requirement in wheat	11
Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance	11
The F1Fo-ATPase inhibitor, IF1, is a critical regulator of energy metabolism in cancer cells	11
Efficiency and equity in origin licensing to ensure complete DNA replication	11
One genome, multiple phenotypes: decoding the evolution and mechanisms of environmentally induced developmental plasticity in insects	11
Controlled power: how biology manages succinate-driven energy release	11
Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease	11
Decoding co-/post-transcriptional complexities of plant transcriptomes and epitranscriptome using next-generation sequencing technologies	11
Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway	11
A pocket guide on how to structure SARS-CoV-2 drugs and therapies	11
Connecting the dots: combined control of endocytic recycling and degradation	11
Polymer models are a versatile tool to study chromatin 3D organization	11
The search for RNA-binding proteins: a technical and interdisciplinary challenge	11
Chromosome clustering in mitosis by the nuclear protein Ki-67	11
The role of chromatin at transcription-replication conflicts as a genome safeguard	11
Post-transcriptional control of mitochondrial protein composition in changing environmental conditions	10
Plant asparaginyl endopeptidases and their structural determinants of function	10
Quinone binding sites of cyt bc complexes analysed by X-ray crystallography and cryogenic electron microscopy	10
CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact	10
The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder	10
Bioengineering silk into blood vessels	10
KRASG12C inhibitor: combing for combination	10
Control of non-productive RNA polymerase II transcription via its early termination in metazoans	10
Ca2+-dependent modulation of voltage-gated myocyte sodium channels	10
Structural insights into NMDA receptor pharmacology	10
Solid-state NMR approaches to investigate large enzymes in complex with substrates and inhibitors	10
Studying actin-induced cell shape changes using Giant Unilamellar Vesicles and reconstituted actin networks	10
Regulation of mTORC1 by the Rag GTPases	10
Diverse roles of microRNA-145 in regulating smooth muscle (dys)function in health and disease	10
Linear ubiquitination in immune and neurodegenerative diseases, and beyond	10
Amyloid precursor protein and its interacting proteins in neurodevelopment	10
NLR immune receptors: structure and function in plant disease resistance	10
Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation	10
The cellular pathways and potential therapeutics of Polycystic Kidney Disease	10
Thermodynamic and structural basis of temperature-dependent gating in TRP channels	10
CRISPR base editing applications for identifying cancer-driving mutations	10
U7 deciphered: the mechanism that forms the unusual 3′ end of metazoan replication-dependent histone mRNAs	10
Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer	9
Membrane protein crystallography in the era of modern structural biology	9
Role of the HOXA cluster in HSC emergence and blood cancer	9
Unravelling mechanisms that govern meiotic crossover formation in wheat	9
Humoral immunity and B-cell memory in response to SARS-CoV-2 infection and vaccination	9
Allosteric regulation and inhibition of protein kinases	9
Cell–matrix and cell–cell interaction mechanics in guiding migration	9
The Eyes Absent proteins in development and in developmental disorders	9
Conquer by cryo-EM without physically dividing	9
Turning the Mre11/Rad50 DNA repair complex on its head: lessons from SMC protein hinges, dynamic coiled-coil movements and DNA loop-extrusion?	9
Extracellular Hsp90 and protection of neuronal cells through Nrf2	9
New insights into promoter–enhancer communication mechanisms revealed by dynamic single-molecule imaging	9
The role of sensory kinase proteins in two-component signal transduction	9
The evolution and structure/function of bHLH–PAS transcription factor family	9