Toxicology

Article	Citations
Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice	175
Editorial Board	116
Roles of N6-methyladenosine in LncRNA changes and oxidative damage in cadmium-induced pancreatic β-cells	86
Differential eigengene network analysis reveals benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin consensus regulatory network in human liver cell line HepG2	72
Investigating the cardiotoxicity of N-n-butyl haloperidol iodide: Inhibition mechanisms on hERG channels	72
Prediction of drug-induced mitochondrial dysfunction using succinate-cytochrome c reductase activity, QSAR and molecular docking	71
Ferrostatin‑1 alleviates liver injury via decreasing ferroptosis following ricin toxin poisoning in rat	57
MLKL triggers NLRP3 activation in sodium arsenite-induced myocardial necroinflammation	57
Deep Learning Algorithm Based on Molecular Fingerprint for Prediction of Drug‐Induced Liver Injury	56
Hexafluoropropylene oxide homologues, the novel alternatives to PFOA, induce mitochondrial dysfunction and cytotoxicity in Leydig cells through disrupting SIRT1/PGC-1α signaling pathway	54
Nutrient molecule corona: An update for nanomaterial-food component interactions	53
The novel polyfluoroalkyl benzenesulfonate OBS exposure induces cell cycle arrest and senescence of rat pituitary cell GH3 via the p53/p21/RB pathway	51
Corrigendum to “Maternal linuron exposure alters testicular development in male offspring rats at the whole genome level” [Toxicology 389 (2017) 13–20]	51
Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress	51
Corrigendum to “Effects of perinatal exposure to bisphenol A on induction of prostate cancer in Sprague Dawley rats by MNU and testosterone” [Toxicology 484 (2023) 153394]	51
Machine learning classification of steatogenic compounds using toxicogenomics profiles	50
Editorial Board Members	50
The formation of lamellar body-like structures may be a trigger of cetylpyridinium chloride-induced cell death and inflammatory response	47
Dimethyl fumarate induces cardiac developmental toxicity in zebrafish via down-regulation of oxidative stress	45
Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-κB/COX-2/RANKL signaling in Sertoli cells	44
Exploring cardiac impact of oral nicotine exposure in a transplantable Neoplasm Mice Model: Insights from biochemical analysis, morphometry, and molecular docking: Chlorella vulgaris green algae suppo	44
Prenatal diesel exhaust exposure enhances neonatal hyperoxia-induced kidney injury via oxidative stress and lipid disruption	40
Comparative study on gene expression profiles in the liver of male neonatal mice prenatally exposed to PFOA and its alternative HFPO-DA	40
Two thyroperoxidase-inhibiting chemicals induce shared transcriptional changes in hippocampus of developing rats	39
Synergism in actions of HBV with aflatoxin in cancer development	38

Activation of α7 nicotinic acetylcholine receptor augments nerve growth factor action on PCtrk cells	38
Chemical effects on neural network activity: Comparison of acute versus network formation exposure in microelectrode array assays	38
Differential effects of mercury compounds on mutagenicity, genotoxicity and repair of UV-DNA damage	38
IL-10-TG/TPO-T4 axis, the target of bis (2-ethylhexyl) tetrabromophthalate on thyroid function imbalance	38
Peritubular myoid cells of the testis produce monocyte chemotactic protein 1 upon direct exposure to Mono-(2-Ethylhexyl) phthalate through the IL-1 signaling pathway	38
Neurotoxicity of Tris (1,3-dichloroisopropyl) phosphate in Caenorhabditis elegans	37
Triclosan has a strong influence on the development of mouse preimplantation embryo via activating miR-134/Nanog axis	36
Establishment of a point of departure for CBD hepatotoxicity employing human HepaRG spheroids	35
A mechanistic toxicology study to grasp the mechanics of zearalenone estrogenicity: Spotlighting aromatase and the effects of its genetic variability	35
Copper oxide nanoparticles disrupt lysosomal function and promote foam cell formation in RAW264.7 macrophages	34
High-throughput screening of respiratory hazards: Exploring lung surfactant inhibition with 20 benchmark chemicals	33
The Cost Outcome Pathway framework: Integrating socio-economic impacts to Adverse Outcome Pathways for supporting policy makers	32
Di-(2-ethylhexyl) phthalate induces prepubertal testicular injury through MAM-related mitochondrial calcium overload in Leydig and Sertoli cell apoptosis	31
Novel flame retardants (NFRs) in e-waste: Environmental burdens, health implications, and recommendations for safety assessment and sustainable management	31
Legacy and alternative per- and polyfluoroalkyl substances (PFAS) alter the lipid profile of HepaRG cells	30
From inhalation to systemic damage: Decoding the mechanistic cascade of silica nanoparticle-induced multi-organ toxicity	30
Organochlorine pesticides: occurrence, spatial distribution of residues, toxicity, and toxic mechanisms	29
The effects of hexabromocyclododecane on the transcriptome and hepatic enzyme activity in three human HepaRG-based models	29
A preliminary study of combined toxicity and underlying mechanisms of imidacloprid and cadmium coexposure using a multiomics integration approach	29
Corrigendum to “Titanium nanoparticles provoke ferritinophagy-mediated ferroptosis via inhibition of the Nrf2-HO-1 signaling pathway in osteocytes’’ [Toxicology 519 (January) (2026) 154324, doi:10.101	29
Edible vegetables grown in the vicinity of electronic wastes: A study of potential health risks and DNA damage in consumers	28
Gold nanoparticle intratesticular injections as a potential animal sterilization tool: Long-term reproductive and toxicological implications	28
Macrophage-epithelial cells crosstalk and the role of CCL2-CCR2 axis in single-walled carbon nanotubes-induced lung inflammation and fibrosis	28
Lambda cyhalothrin and chlorantraniliprole caused biochemical, histological, and immunohistochemical alterations in male rabbit liver: Ameliorative effect of vitamins A, D, E, C mixture	27
Corrigendum to “Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats” [Toxicology 449 (2021) 152665]	27
Per- and polyfluoroalkyl substances as potentiators of hepatotoxicity in an exposome framework: Current challenges of environmental toxicology	27
Exposure to polystyrene nanoplastics promotes premature cellular senescence through mitochondrial ROS production and dysfunction in pre-differentiated skeletal myoblasts	26
Microplastics/nanoplastics and neurological health: An overview of neurological defects and mechanisms	26
ROS-mediated NRF2/p-ERK1/2 signaling-involved mitophagy contributes to macrophages activation induced by CdTe quantum dots	26
Predictive, integrative, and regulatory aspects of AI-driven computational toxicology – Highlights of the German Pharm-Tox Summit (GPTS) 2024	26
Pb inhibited C2C12 myoblast differentiation by regulating HDAC2	26
Predicting in vitro assays related to liver function using probabilistic machine learning	25
Toxic talk: pannexin1 channel communication as an emerging mechanism of toxicity	25
Corrigendum to “Inhibitory effects of parabens on human and rat 17β-hydroxysteroid dehydrogenase 1: Mechanisms of action and impact on hormone synthesis” Toxicology 506 (August) (2024) 153873	25
Assessing micro and nanoplastics toxicity using rodent models: Investigating potential mitochondrial implications	24
GenX induces fibroinflammatory gene expression in primary human hepatocytes	24
Ferroptosis is involved in cisplatin sensitivity of the S3 segment of immortalized proximal tubule cells	24
MLKL deficiency alleviates acute alcoholic liver injury via inhibition of NLRP3 inflammasome	24
Increased TSLP and oxidative stress reflect airway epithelium injury upon cigarette smoke exposure. Is there a role for carbocysteine?	24
OTSSP167 leads to follicular dysplasia and negatively affects oocyte quality in mice	24
Cytotoxicity and pro-inflammatory effect of polystyrene nano-plastic and micro-plastic on RAW264.7 cells	24
In vitro toxicological evaluation of glo menthol and non-menthol heated tobacco products	24
Mechanistic insights into TDCPP-induced DNA damage in GT1-7 cells	24
Effects of ELF-PEMF exposure on spontaneous alternation, anxiety, motor co-ordination and locomotor activity of adult wistar rats and viability of C6 (Glial) cells in culture	24
Fine particulate matter disrupts bile acid homeostasis in hepatocytes via binding to and activating farnesoid X receptor	24
Benzyl butyl phthalate promotes ferroptosis in Sertoli cells via disrupting ceruloplasmin-mediated iron balance	24
Immunotoxicity of 2-Acetyl-4-tetrahydroxybutylimidazole in BALB/c mice with different vitamin B6 nutritional statuses	23
The effects of fumonisin B1 on intercellular communications and miRNA modulations: Non-genotoxic carcinogenesis mechanisms in human kidney cells	23
N-isopropylbenzylamine, a methamphetamine mimics, produces toxicity via increasing nitric oxide in vitro	23
PM2.5 exposure exacerbates airway pyroptosis related inflammatory response in asthmatic mice by activating NLRP3 inflammasome	23

Persistent organic pollutants: Neurotoxic mechanisms and insights from organoid models	22
Combined exposure to polystyrene nanoplastics and bisphenol A results in mitochondrial damage and ferroptosis via the PI3K-AKT signaling pathway in mice kidneys	22
Corrigendum to “Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity” [Toxicology 487 (2023) 1–13]	22
Integrative assessment of endocrine disruption: From in vitro mechanisms to species extrapolation – Highlights of the German Pharma-Tox Summit 2025	22
The p,p’-DDE disturbs the M1 function without affecting the M2 phenotype nor unstimulated bone marrow-derived macrophages from BALB/c mice	22
Corrigendum to “Chronic oral depleted uranium leads to reproductive damage in male rats through the ROS-hnRNP A2/B1-COX-2 signaling pathway” [Toxicology 449 (2021) 152666]	22
NAM-based prediction of point-of-contact toxicity in the lung: A case example with 1,3-dichloropropene	21
Hematological, cardiovascular and oxidative DNA damage markers associated with heavy metal exposure in electronic waste (e-waste) workers of Bangladesh	21
A comprehensive review of the proline mimic azetidine-2-carboxylic acid (A2C)	21
Endocrine toxicity of atrazine and its underlying mechanisms	21
Protective effect of dental pulp stem cells' conditioned medium against cisplatin-induced testicular damage in rats	21
Retraction notice to “Arsenic-induced mitochondrial instability leading to programmed cell death in the exposed individuals" [Toxicology 246 (2008) 101–111]	20
PM2.5 induces mitochondrial dysfunction via AHR-mediated cyp1a1 overexpression during zebrafish heart development	20
Editorial Board	20
Influence of polystyrene nanoparticles on the toxicity of tetrabromobisphenol A in human intestinal cell lines	20
Editorial Board	20
Maternal urban particulate matter exposure and signaling pathways in fetal brains and neurobehavioral development in offspring	19
Exposure to volatile organic compounds induces cardiovascular toxicity that may involve DNA methylation	19
Three-dimensional cultured ampullae from rats as a screening tool for vestibulotoxicity: Proof of concept using styrene	19
Analysis of the expression and function of ITGB6 in porcine intestinal epithelial cells upon deoxynivalenol exposure	19
Interaction and toxicity of ingested nanoparticles on the intestinal barrier	19
Effects of methoxychlor on broiler gut microbiota and liver and its residue accumulation risk to human health	19
Long-term low-dose N, N-dimethylformamide exposure disturbs hepatic lipid and glucose homeostasis in mice	19
Bisphenol A induced neuronal apoptosis and enhanced autophagy in vitro through Nrf2/HO-1 and Akt/mTOR pathways	19
Neonatal exposure of bisphenol A led to increased lipolysis of visceral adipose tissue in adult rats with DNA hypomethylation of Atgl being one of the possible underlying mechanisms	19
Multi-omics analysis reveals BPF exposure causes hepatic glucose and lipid metabolism disorder in rats by disrupting energy homeostasis	19
The correlation between lung surfactant function inhibition in vitro and the effect on breathing of mice during inhalation exposure – A study of spray-formulated engine/brake cleaners and lubricating	19
Characterising a HepaRG liver microphysiological system for individual bile acid secretion and chemical induced disruptions	19
Exposure to TCBPA stimulates the growth of arterial smooth muscle cells through the activation of the ROS/NF-κB/NLRP3 signaling pathway	18
A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy	18
Ochratoxin A stimulates release of IL-1β, IL–18 and CXCL8 from cultured human microglia	18
Considerations for future quantitative structure-activity relationship (QSAR) modelling for heavy metals – A case study of mercury	18
Immunotoxic effect and mechanisms of Fusarium mycotoxins on human immune cells: A focus on T cells and macrophages	18
Hepatic lipid metabolism disorders and immunotoxicity induced by cysteamine in early developmental stages of zebrafish	18
Evaluation of mutagenic, cytotoxic, mitochondrial dysfunction, apoptotic activity, and acute toxicity of ethanolic extract of Cissus quadrangularis	18
Effect of the extra-nuclear cation on the cytotoxicity and mechanism of action of pyridine-2,6-dicarboxylate Ga(III) complexes	18
Gestational exposure to BPA alters the expression of glucose and lipid metabolic mediators in the placenta: Role in programming offspring for obesity	18
Editorial Board	18
Comprehensive analysis of the impact of emerging flame retardants on prostate cancer progression: The potential molecular mechanisms and immune infiltration landscape	18
The effects of direct addition of lead(ii) acetate to a human in vitro model of hematopoiesis recapitulates exposure to lead in utero	18
Fluoride induced metabolic disorder of endothelial cells	18
Embryonic exposure to GenX causes reproductive toxicity by disrupting the formation of the blood-testis barrier in mouse offspring	17
Comparative evaluation of mutagenic, genotoxic, cytotoxic, and antimicrobial effects of flavour and fragrance aldehydes, ketones, oximes, and oxime ethers	17
Long-term low-dose exposure to polystyrene nanoplastics induces morphological and transcriptional reprogramming to enhance metastatic potential of colorectal cancer cells	17
Silica nanoparticles induce pulmonary damage in rats via VEGFC/D–VEGFR3 signaling-mediated lymphangiogenesis and remodeling	17
A computational study on the biotransformation of alkenylbenzenes by a selection of CYPs: Reflections on their possible bioactivation	17
CYP2E1 mediated deoxynivalenol-induced hepatocyte toxicity by regulating ferroptosis	17
Dihydrotestosterone induces reactive oxygen species accumulation and mitochondrial fission leading to apoptosis of granulosa cells	17
Polystyrene microplastics aggravate acute pancreatitis in mice	17
Ameliorative effects of the phytochemicals in dates (Phoenix dactylifera) against the toxicological changes induced by fipronil in male albino rats	17
Toxicological effects of PM2.5-derived and PM2.5-relevant mixture of chlorinated paraffins on A549/THP-1 co-culture cells	17
The variability in CYP3A4 activity determines the metabolic kinetic characteristics of ketamine	17
PFHxS exposure causes osteoarthritis through the innate immune signaling pathway mediated by lipid peroxidation	17
Developments in the field of intestinal toxicity and signaling pathways associated with rodent exposure to micro(nano)plastics	17
Exposure to organophosphate flame retardants and phthalates alters neuronal activity and network development	16
Dynamic analysis of intrahepatic T cells reveals a unique group of restorative Cxcr3 tissue-resident CD4 T cells in acute liver injury	16
Hematological consequences of polyethylene microplastics toxicity in male rats: Oxidative stress, genetic, and epigenetic links	16
RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice	16
Knock-down of FOXO3, GATA2, NFE2L2 and AHR promotes doxorubicin-induced cardiotoxicity in human cardiomyocytes	16
Autophagy alleviates hippocampal neuroinflammation by inhibiting the NLRP3 inflammasome in a juvenile rat model exposed particulate matter	16
Chronic D-galactose administration induces natural aging characteristics, in rat’s brain and heart	15
Ophiopogonin D′-induced mitophagy and mitochondrial damage are associated with dysregulation of the PINK1/Parkin signaling pathway in AC16 cells	15
Health impacts of PM2.5 emissions from brake pad wear: A comprehensive study on pulmonary, metabolic, and microbiota alterations	15
A mechanistically-anchored and human stem cell-based in vitro test battery for assessing liver steatogenic potential of chemicals	15
Polystyrene microplastics induced oxidative stress, inflammation and necroptosis via NF-κB and RIP1/RIP3/MLKL pathway in chicken kidney	15
The dysbiosis of gut microbiota attributes to the impairment of blood-brain barrier in rats triggered by cadmium	15
The effects and mechanism of LncRNA NORAD on doxorubicin-induced cardiotoxicity	15
Role of myo-inositol in acute kidney injury induced by cisplatin	15
Investigation of a broad diversity of nanoparticles, including their processes, as well as toxicity testing in diverse organs and systems	15
Notch1-dependent hippocampal apoptosis is associated with monocrotaline-induced anxiety-like behavior	15
Genotoxicity assessment of 1,4-anhydro-4-seleno-D-talitol (SeTal) in human liver HepG2 and HepaRG cells	15
Tetrabromobisphenol S (TBBPS) exposure causes gastric cell senescence and inflammation by inducing iron overload	15
Recombinant Klotho alleviates vancomycin-induced acute kidney injury by upregulating anti-oxidative capacity via JAK2/STAT3/GPx3 axis	15
Editorial Board Members	15
Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays	15
Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health	15
Sintilimab combined with acetaminophen aggravates liver injury through apoptotic and disturbed bile acid pathways	15
Graphene quantum dots disturbed the energy homeostasis by influencing lipid metabolism of macrophages	15
Lycium barbarum polysaccharides attenuate nonylphenol and octylphenol-induced oxidative stress and neurotransmitter disorders in PC-12 cells	15
Neurotoxic effects and cognitive decline induced by Aniline Blue dye in an in-vivo zebrafish model	14

Differential susceptibility of Leydig and Sertoli cells to bisphenol A	14
Teratological, neurochemical and histomorphic changes in the limbic areas of F1 mice progeny due to co-parental polystyrene nanoplastic exposure	14
Effect of modified citrus pectin on galectin-3 inhibition in cisplatin-induced cardiac and renal toxicity	14
Palmitic acid induced the onset of lipotoxicity in a HepaSH-on-chip model with raised of H2O2 and IL-6, and altered p38/MAPK & JAK/STAT pathways	14
Cadmium promotes hyaluronan synthesis by inducing hyaluronan synthase 3 expression in cultured vascular endothelial cells via the c-Jun N-terminal kinase–c-Jun pathway	14
Food-borne polystyrene microplastic exposure exacerbates cognitive deficiency via enhanced neuronal synaptic damage and neuroinflammation in Alzheimer's disease	14
Ex vivo exposure to p,p'-DDE decreases human macrophage polarization to the M1 phenotype	14
Effect of persistent organic pollutants in patients with ischemic stroke and all stroke: A systematic review and meta-analysis	14
6PPD induces apoptosis and autophagy in SH-SY5Y cells via ROS-mediated PI3K/AKT/mTOR pathway: In vitro and in silico approaches	14
Environmentally relevant concentrations of individual per- and polyfluoroalkyl substances (PFAS) and a PFAS mixture impact proliferation, migration, and gene transcription in a human myometrial cell l	14
Dynamics and mechanisms of bioaccumulation and elimination of nonylphenol in zebrafish	14
Upregulation of postsynaptic cAMP/PKA/CREB signaling alleviates copper(Ⅱ)-induced oxidative stress and pyroptosis in MN9D cells	14
Arsenic induces metabolome remodeling in mature human adipocytes	14
Long-term exposure to polystyrene microplastics reduces macrophages and affects the microbiota–gut–brain axis in mice	14
In vitro test battery for testing molecular initiating events in chemical-induced cholestasis	14
A metabolomic approach to study triptolide-induced ovarian damage in rats	14
Increasing confidence in new approach methodologies for inhalation risk assessment with multiple end point assays using 5-day repeated exposure to 1,3-dichloropropene	14
Antiparasitic agent emodepside exerts cytotoxicity in human corneal stromal cells by blocking the interaction between mini-chromosome maintenance 6 protein (MCM6) and chromatin licensing and DNA repli	13
Di-n-butyl phthalate regulates vascular smooth muscle cells phenotypic switching by MiR-139–5p-MYOCD pathways	13
Long-term exposure to arsenic in drinking water leads to myocardial damage by oxidative stress and reduction in NO	13
Cadmium induces spontaneous abortion by impairing endometrial stromal cell decidualization	13
Toxicological evaluation of vape liquids circulating in Brazil: Evidence of emerging hazards	13
The crucial involvement of gamma-Mangostin and CYP1B1 in the mechanism underlying the toxicity caused by cigarette smoke extract: In silico and in vitro insights	13
Obituary for Karl Joachim Netter	13
Corrigendum to: “Benzo[a]pyrene exposure promotes RIP1-mediated necroptotic death of osteocytes and the JNK/IL-18 pathway activation via generation of reactive oxygen species” [Toxicology, 476, June 2	13
Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity	13
Loperamide induces excessive accumulation of bile acids in the liver of mice with different diets	13
Mechanisms involved in pro-inflammatory responses to traffic-derived particulate matter (PM) in THP-1 macrophages compared to HBEC3-KT bronchial epithelial cells	13
Virtual display of targets: A new level to rise the current understanding of ochratoxin A toxicity from a molecular standpoint	13
Utilization of the CometChip assay for detecting PAH-induced DNA bulky adducts in a 3D primary human bronchial epithelial cell model	13
Ripretinib induced skeletal muscle toxicity through mitochondrial impairment in C2C12 myotubes	12
Editorial Board Members	12
Glutathione attenuates diesel exhaust-induced lung epithelial injury via NF-κB/Nrf2/GPX4-mediated ferroptosis	12
Editorial Board	12
AFB1 consolidates HBV harm to induce liver injury and carcinogenic risk by inactivating FTCD-AS1-PXR-MASP1 axis	12
Tobacco smoking exposure-mediated ELAVL1 regulates bladder cancer cell senescence via autophagy activation	12
Effect of monosultap on notochord development in zebrafish (Danio rerio) embryos	12
Chlorpyrifos impairs sperm parameters and number of Sertoli and Leydig cells in rats after exposure during the peripubertal period	12
Lycopene alleviates Deoxynivalenol-induced toxicity in Porcine intestinal epithelial cells by mediating mitochondrial function	12
MCF-7 cell - derived exosomes were involved in protecting source cells from the damage caused by tributyltin chloride via transport function	12
Mirabegron alleviates acetic acid-induced colitis in rats: Role of adiponectin and GSTM1/GSH detoxification pathway	12
Polycyclic aromatic hydrocarbons-enriched diesel exhaust particles induced hypertrophy in rat primary neonatal cardiomyocytes and apoptotic cell death in H9c2 cardiomyocytes	12
Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis	12
Linking AhR and Nrf2 activation to neurotoxicity through adverse outcome pathway-based machine learning	11
Polystyrene microplastics trigger colonic inflammation in rats via the TLR4/NF-κB/COX-2 pathway and modulation of intestinal microbiota	11
Bisphenol AP promotes pulmonary fibrosis by regulating macrophage function in a bleomycin-induced mouse model	11
InterDIA: Interpretable prediction of drug-induced autoimmunity through ensemble machine learning approaches	11
Effects of endocrine disrupting chemicals on the expression of RACK1 and LPS-induced THP-1 cell activation	11
Protective effects of vitamin E against acrylamide-induced hepatotoxicity and nephrotoxicity from fetal development to adulthood: Insights into Akt/NF-κB and Bcl-xL/Bax signaling pathways	11
Multi-omics analyses of serum metabolome, urine metabolome and gut microbiome reveal dysregulated glycerophospholipid metabolism in subacute cadmium-exposed wistar rats	11
Investigating the functional role of BUB1B in aflatoxin B1-associated hepatocarcinogenesis	11
Advances in antituberculosis drug-induced liver injury: Molecular mechanisms, genetic insights, and emerging animal-free prediction models	11
A next generation physiologically-based kinetic model for quantitative in vitro to in vivo extrapolation of cisplatin-induced nephrotoxicity in humans	11
Exploring the dynamics of the ABCB1 membrane transporter P-glycoprotein in the presence of ATP and active/non-active compounds through molecular dynamics simulations	11
Occurrence and ecotoxicological impacts of polybrominated diphenyl ethers (PBDEs) in electronic waste (e-waste) in Africa: Options for sustainable and eco-friendly management strategies	11
Establishing allometric relationships between microsomal protein and cytochrome P450 content with body weight in vertebrate species	11
Neurodevelopment effects of early life bisphenol-A exposure on visual memory: Insights into recovery dynamics	11
Prenatal exposure to dibutyl phthalate contributes to erectile dysfunction in offspring male rats by activating the RhoA/ROCK signalling pathway	11
AhR/ROS-mediated endoplasmic reticulum stress contributes to PFOSA-induced cardiac defects	11
Involvement of ARTS in bisphenol A-induced apoptosis of mouse Leydig cells	11
Chronic low-level exposure to Pb, Hg, and Cd mixture triggers brain premature aging in rat	11
Evaluating combined effects of chronic, low-dose exposures of cadmium (CLEC) and hyperglycemia on insulin signaling dysfunction in a hepatocellular model	11
Effects of miR-200b-3p and miR-424–5p regulating notch signaling pathway on atherosclerosis induced by PM2.5 in vitro	11
Stress-related testicular changes in Wistar and Sprague-Dawley rats following oral administration of an interleukin-8 inhibitor	10
Response to commentary on “Pulmonary toxicity, genotoxicity, and carcinogenicity evaluation of molybdenum, lithium, and tungsten: A review”	10
ATF4/PHGDH mediates the effects of ER stress on cadmium-induced autophagy and glycolysis	10
Protective autophagy alleviates neurotoxin-gelsenicine induced apoptosis through PERK signaling pathway in Neuro-2a cells	10
Low-dose arsenic trioxide enhances membrane-GLUT1 expression and glucose uptake via AKT activation to support L-02 cell aberrant proliferation	10
ToxProfiler: A novel human-based reporter assay for in vitro chemical safety assessment	10
Prepubertal exposure to gadolinium-based contrast agents impairs sperm quality and elevates oxidative stress in adult rats	10
Metformin inhibits OCTN1- and OCTN2-mediated hepatic accumulation of doxorubicin and alleviates its hepatotoxicity in mice	10
Bioinformatics identification of shared signaling pathways and core targets linking Benzo[a]pyrene exposure to HCC progression	10
Long-term Bisphenol S exposure induced gut microbiota dysbiosis, obesity, hepatic lipid accumulation, intestinal lesions and dyslipidemia in mice	10
Overexpressed miRNA-nov-1 promotes manganese-induced apoptosis in N27 cells by regulating Dhrs3 to activate mTOR signaling pathway	10
Inhibitory effects of flavonoids on glucose transporter 1 (GLUT1): From library screening to biological evaluation to structure-activity relationship	10
Bag2 protects against doxorubicin-induced cardiotoxicity by maintaining Pink1-mediated mitophagy	10
Insight into mitochondrial dysfunction mediated by clozapine-induced inhibition of PGRMC1 in PC12 cells	10
Antimony induces mitochondria-dependent and ER stress-triggered apoptosis via the oxidative stress-activated JNK signaling pathway in pancreatic islet β-cells	10
Enantiospecific hepatotoxicity of usnic acid in vitro, and the attempt to modify the toxic effect	10
Research progress and prospect on the safety of heated tobacco products	10
Immunotoxicity of relevant mixtures of pesticides and metabolites on THP-1 cells	10
Vascular endothelial growth factor-containing conditioned medium from PFOS-exposed human granulosa cells promotes endothelial angiogenesis in vitro	10
AI-based toxicity prediction models using ToxCast data: Current status and future directions for explainable models	10
A scalable human liver-on-a-chip platform for predictive safety assessment	10
Synergistic effects of lead and copper co-exposure on promoting oxidative stress and apoptosis in the neuronal cells	10
MiR-24–3p/Dio3 axis is essential for BDE47 to induce local thyroid hormone disorder and neurotoxicity	10
Toxicological mechanisms of emerging per-/poly-fluoroalkyl substances: Focusing on transcriptional activity and gene expression disruption	10
Examining the immunotoxicity of oil sands process affected waters using a human macrophage cell line	10
Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induces intestinal toxicity in mice	10
Prediction of polybrominated diphenyl ethers (PBDEs) as potential substrates of various human CYP enzymes and laboratory test of BDE-99 for its metabolism-activated mutagenicity	10
Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model	10
Clinical and experimental research progress on neurotoxicity of sulfur mustard and its possible mechanisms	10
Editorial Board	10
Effects of radon exposure on gut microbiota and its metabolites short-chain fatty acids in mice	10
Editorial Board	10