Toxicology

Article	Citations
Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects	210
Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats	158
A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®	90
Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease	89
Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice	76
Heavy metals induced mitochondrial dysfunction in animals: Molecular mechanism of toxicity	69
Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease	61
Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice	60
NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in swine	58
Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure	57
Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms	54
Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro	43
Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury	41
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells	41
Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms	41
AHR/ROS-mediated mitochondria apoptosis contributes to benzo[a]pyrene-induced heart defects and the protective effects of resveratrol	36
The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway	36
The mechanism of the cadmium-induced toxicity and cellular response in the liver	36
Effects and mechanisms of pyrethroids on male reproductive system	35
The way forward for assessing the human health safety of cosmetics in the EU - Workshop proceedings	34
Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats	33
Vipers of Major clinical relevance in Europe: Taxonomy, venom composition, toxicology and clinical management of human bites	33
Aspirin eugenol ester ameliorates paraquat-induced oxidative damage through ROS/p38-MAPK-mediated mitochondrial apoptosis pathway	33
Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model	32
ROS and iron homeostasis dependent ferroptosis play a vital role in 5-Fluorouracil induced cardiotoxicity in vitro and in vivo	32

Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis	32
Paraquat exposure over generation affects lifespan and reproduction through mitochondrial disruption in C. elegans	32
Safer chemicals using less animals: kick-off of the European ONTOX project	32
Phosgene inhalation toxicity: Update on mechanisms and mechanism-based treatment strategies	31
Exposure to a mixture of heavy metals induces cognitive impairment: Genes and microRNAs involved	31
Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4/NF-κB/NLRP3 signaling pathway	31
Oxaliplatin-induced hepatic sinusoidal obstruction syndrome	30
Environmental and occupational pesticide exposure and human sperm parameters: A Navigation Guide review	30
Arsenic methylation – Lessons from three decades of research	30
Blood lead levels and male reproductive hormones: A systematic review and meta-analysis	29
Nutrition, one-carbon metabolism and arsenic methylation	29
Inhibition of ferroptosis reduces susceptibility to frequent excessive alcohol consumption-induced atrial fibrillation	28
Alternative animal models in predictive toxicology	28
Cadmium induces endoplasmic reticulum stress-mediated apoptosis in pig pancreas via the increase of Th1 cells	28
Ozone exposure promotes pyroptosis in rat lungs via the TLR2/4-NF-κB-NLRP3 signaling pathway	28
Apoptotic activities of brusatol in human non-small cell lung cancer cells: Involvement of ROS-mediated mitochondrial-dependent pathway and inhibition of Nrf2-mediated antioxidant response	28
Adipose mesenchymal stem cell-derived antioxidative extracellular vesicles exhibit anti-oxidative stress and immunomodulatory effects under PM2.5 exposure	27
Mitochondria damage and ferroptosis involved in Ni-induced hepatotoxicity in mice	26
Nicotine stimulates IL-8 expression via ROS/NF-κB and ROS/MAPK/AP-1 axis in human gastric cancer cells	26
Methyl parathion causes genetic damage in sperm and disrupts the permeability of the blood-testis barrier by an oxidant mechanism in mice	26
Cigarette smoking exposure breaks the homeostasis of cholesterol and bile acid metabolism and induces gut microbiota dysbiosis in mice with different diets	26
Glycyrrhizin improved autophagy flux via HMGB1-dependent Akt/mTOR signaling pathway to prevent Doxorubicin-induced cardiotoxicity	26
Cadmium induces apoptosis via generating reactive oxygen species to activate mitochondrial p53 pathway in primary rat osteoblasts	25
Effect of uncontrolled fertilization and heavy metal toxicity associated with arsenic(As), lead(Pb) and cadmium (Cd), and possible remediation	25
Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs	25
Cadmium exposure induces TNF-α-mediated necroptosis via FPR2/TGF-β/NF-κB pathway in swine myocardium	25
Ubiquitous plasticizer, Di-(2-ethylhexyl) phthalate enhances existing inflammatory profile in monocytes of children with autism	24
Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS)	24
Exposure to PM2.5 aggravates Parkinson’s disease via inhibition of autophagy and mitophagy pathway	24
Metabolic, reproductive and thyroid effects of bis(2-ethylhexyl) phthalate (DEHP) orally administered to male and female juvenile rats at dose levels derived from children biomonitoring study	24
Glyphosate-based herbicides: Evidence of immune-endocrine alteration	24
Mechanisms and treatment strategies of organophosphate pesticide induced neurotoxicity in humans: A critical appraisal	24
Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A	23
Glyphosate Induces Metaphase II Oocyte Deterioration and Embryo Damage by Zinc Depletion and Overproduction of Reactive Oxygen Species	23
Bayesian benchmark dose analysis for inorganic arsenic in drinking water associated with bladder and lung cancer using epidemiological data	23
Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro	23
Amorphous nanosilica induced toxicity, inflammation and innate immune responses: A critical review	23
Microphysiological system modeling of ochratoxin A-associated nephrotoxicity	23
Derivation, characterisation and analysis of an adverse outcome pathway network for human hepatotoxicity	23
Ca2+/CaM/CaMK signaling is involved in cadmium-induced osteoclast differentiation	23
Tert-butylhydroquinone preserve testicular steroidogenesis and spermatogenesis in cisplatin-intoxicated rats by targeting oxidative stress, inflammation and apoptosis	23
Formaldehyde induces ferroptosis in hippocampal neuronal cells by upregulation of the Warburg effect	22
In-vitro toxicity of molybdenum trioxide nanoparticles on human keratinocytes	22
Liver toxicity of macrolide antibiotics in zebrafish	22
Poloxamer 188-mediated anti-inflammatory effect rescues cognitive deficits in paraquat and maneb-induced mouse model of Parkinson’s disease	22
Perfluorooctane sulfonate (PFOS) disrupts testosterone biosynthesis via CREB/CRTC2/StAR signaling pathway in Leydig cells	22
Environmental pollutants exposure and male reproductive toxicity: The role of epigenetic modifications	21
SIRT4 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the AKT/mTOR/Autophagy Pathway	21
Salidroside alleviates liver inflammation in furan-induced mice by regulating oxidative stress and endoplasmic reticulum stress	21
Investigating the cytotoxicity of per- and polyfluoroalkyl substances in HepG2 cells: A structure-activity relationship approach	21

Benzo[a]pyrene immunogenetics and immune archetype reprogramming of lung	20
Involvement of endoplasmic reticulum stress response and IRE1-mediated ASK1/JNK/Mcl-1 pathways in silver nanoparticle-induced apoptosis of human retinal pigment epithelial cells	20
Subacute cadmium exposure promotes M1 macrophage polarization through oxidative stress-evoked inflammatory response and induces porcine adrenal fibrosis	20
A review of low-dose arsenic risks and human cancers	20
Alpha-lipoic acid effectively attenuates ionizing radiation-mediated testicular dysfunction in rats: Crosstalk of NF-ĸB, TGF-β, and PPAR-ϒ pathways	20
Molecular toxicity of methotrexate in rheumatoid arthritis treatment: A novel perspective and therapeutic implications	20
Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum	20
The impact of legacy and novel perfluoroalkyl substances on human cytochrome P450: An in vitro study on the inhibitory potential and underlying mechanisms	19
Structure-activity relationship analysis of perfluoroalkyl carbonic acids on human and rat placental 3β-hydroxysteroid dehydrogenase activity	19
Prenatal dexamethasone exposure caused fetal rats liver dysplasia by inhibiting autophagy-mediated cell proliferation	19
Bioactivation of clozapine by mitochondria of the murine heart: Possible cause of cardiotoxicity	19
Comparative toxicities of BPA, BPS, BPF, and TMBPF in the nematode Caenorhabditis elegans and mammalian fibroblast cells	19
Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice	19
Cadmium disrupts mitochondrial distribution and activates excessive mitochondrial fission by elevating cytosolic calcium independent of MCU-mediated mitochondrial calcium uptake in its neurotoxicity	19
Cannabidiol selectively modulates interleukin (IL)-1β and IL-6 production in toll-like receptor activated human peripheral blood monocytes	19
TGF-β-activated kinase 1 (TAK1) mediates cadmium-induced autophagy in osteoblasts via the AMPK / mTORC1 / ULK1 pathway	19
Resveratrol ameliorates disorders of mitochondrial biogenesis and mitophagy in rats continuously exposed to benzo(a)pyrene from embryonic development through adolescence	19
Lead (Pb) induced Oxidative Stress as a Mechanism to Cause Neurotoxicity in Drosophila melanogaster	19
Bisphenol S promotes the progression of prostate cancer by regulating the expression of COL1A1 and COL1A2	19
Nanosafety vs. nanotoxicology: adequate animal models for testing in vivo toxicity of nanoparticles	19
A comparative study based on activity, conformation and computational analysis on the inhibition of human salivary aldehyde dehydrogenase by phthalate plasticizers: Implications in assessing the safet	19
Ustilaginoidin D induces hepatotoxicity and behaviour aberrations in zebrafish larvae	19
Roles of ERK/Akt signals in mitochondria-dependent and endoplasmic reticulum stress-triggered neuronal cell apoptosis induced by 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a major active metabolite	19
Cadmium induces apoptosis of pig lymph nodes by regulating the PI3K/AKT/HIF-1α pathway	18
Changes induced by chronic exposure to high arsenic concentrations in the intestine and its microenvironment	18
Alpha-Synuclein deficiency ameliorates chronic methamphetamine induced neurodegeneration in mice	18
3-Indolepropionic acid upturned male reproductive function by reducing oxido-inflammatory responses and apoptosis along the hypothalamic-pituitary-gonadal axis of adult rats exposed to chlorpyrifos	18
Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity	18
Aflatoxin B1 interferes with embryonic liver development: Involvement of p53 signaling and apoptosis in zebrafish	18
Relative comparison of strobilurin fungicides at environmental levels: Focus on mitochondrial function and larval activity in early staged zebrafish (Danio rerio)	18
The use of calcium carbide in food and fruit ripening: Potential mechanisms of toxicity to humans and future prospects	18
The effects of cadmium on the development of Drosophila and its transgenerational inheritance effects	18
Zearalenone exposure mediated hepatotoxicity via mitochondrial apoptotic and autophagy pathways: Associated with gut microbiome and metabolites	18
Multi-walled carbon nanotubes exacerbate doxorubicin-induced cardiotoxicity by altering gut microbiota and pulmonary and colonic macrophage phenotype in mice	18
Health repercussions of environmental exposure to lead: Methylation perspective	17
Protective effects of chrysin against the neurotoxicity induced by aluminium: In vitro and in vivo studies	17
Structure-based Identification of Endocrine Disrupting Pesticides Targeting Breast Cancer Proteins	17
Atrazine impairs testicular function in BalB/c mice by affecting Leydig cells	17
Cytotoxicity and genotoxicity of low-dose vanadium dioxide nanoparticles to lung cells following long-term exposure	17
The effects of bisphenol A and bisphenol S on adipokine expression and glucose metabolism in human adipose tissue	17
The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure	16
Bisphenol A exposure prenatally delays bone development and bone mass accumulation in female rat offspring via the ERβ/HDAC5/TGFβ signaling pathway	16
Interleukin 33 mediates hepatocyte autophagy and innate immune response in the early phase of acetaminophen-induced acute liver injury	16
The dynamicity of acute ozone-induced systemic leukocyte trafficking and adrenal-derived stress hormones	16
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation	16
Altered expression of glutamatergic and GABAergic genes in the valproic acid-induced rat model of autism: A screening test	16
Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-κB pathway and anxiety-like behavior in male C57BL/6 mice	16
Pulmonary toxicity, genotoxicity, and carcinogenicity evaluation of molybdenum, lithium, and tungsten: A review	16
Effects of phthalates on the functions and fertility of mouse spermatozoa	15
Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects	15
Perfluoroheptanoic acid induces Leydig cell hyperplasia but inhibits spermatogenesis in rats after pubertal exposure	15
Inhalation exposure by cigarette smoke: Effects on the progression of bleomycin- and lipopolysaccharide-induced lung injuries in rat models	15
Chronic consumption of food-additives lead to changes via microbiota gut-brain axis	15
Impaired mitochondrial function of alveolar macrophages in carbon nanotube-induced chronic pulmonary granulomatous disease	15
Nutrient molecule corona: An update for nanomaterial-food component interactions	15
Polystyrene nanoplastics exacerbate lipopolysaccharide-induced myocardial fibrosis and autophagy in mice via ROS/TGF-β1/Smad	15
Di-(2-ethyl hexyl) phthalate induced oxidative stress promotes microplastics mediated apoptosis and necroptosis in mice skeletal muscle by inhibiting PI3K/AKT/mTOR pathway	15
Exploring the aging effect of the anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial proteome using a murine model	15
Prepubertal arsenic exposure alters phosphoproteins profile, quality, and fertility of epididymal spermatozoa in sexually mature rats	15
Perfluorooctane sulfonate (PFOS) exposure of bovine oocytes affects early embryonic development at human-relevant levels in an in vitro model	15
Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam	15
Transplacental arsenic exposure produced 5-methylcytosine methylation changes and aberrant microRNA expressions in livers of male fetal mice	15
Protective effects of Folic acid against reproductive, hematological, hepatic, and renal toxicity induced by Acetamiprid in male Albino rats	15
Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP	15
Comparative cytotoxicity of seven per- and polyfluoroalkyl substances (PFAS) in six human cell lines	15
Involvement of CYP2E1-ROS-CD36/DGAT2 axis in the pathogenesis of VPA-induced hepatic steatosis in vivo and in vitro	15
NADPH protects against kainic acid-induced excitotoxicity via autophagy-lysosome pathway in rat striatum and primary cortical neurons	15
Toxicity of engineered nanomaterials with different physicochemical properties and the role of protein corona on cellular uptake and intrinsic ROS production	15
Developmental lead (Pb)-induced deficits in redox and bioenergetic status of cerebellar synapses are ameliorated by ascorbate supplementation	15
LCZ696 (sacubitril/valsartan) protects against cyclophosphamide-induced testicular toxicity in rats: Role of neprilysin inhibition and lncRNA TUG1 in ameliorating apoptosis	15
Environmental factors modulating protein conformations and their role in protein aggregation diseases	14
Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat	14
Assessing the neurotoxicity of the carbamate methomyl in Caenorhabditis elegans with a multi-level approach	14
The protective effect of trilobatin against isoflurane-induced neurotoxicity in mouse hippocampal neuronal HT22 cells involves the Nrf2/ARE pathway	14
Inhibition of TBK1 by amlexanox attenuates paraquat-induced acute lung injury	14
Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study	14
Redox-sensitive Nrf2 and MAPK signaling pathways contribute to trichloroethene-mediated autoimmune disease progression	14
Effects of butylparaben exposure on thyroid peroxidase (TPO) and type 1 iodothyronine deiodinase (D1) in female Wistar rats	14
Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells	14
Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent	14

Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone	14
Prepubertal acrylamide exposure causes dose-response decreases in spermatic production and functionality with modulation of genes involved in the spermatogenesis in rats	14
Polystyrene microplastics induced oxidative stress, inflammation and necroptosis via NF-κB and RIP1/RIP3/MLKL pathway in chicken kidney	13
METTL3-mediated M6A methylation modification is involved in colistin-induced nephrotoxicity through apoptosis mediated by Keap1/Nrf2 signaling pathway	13
Long noncoding RNA-SNHG20 promotes silica-induced pulmonary fibrosis by miR-490-3p/TGFBR1 axis	13
Developmental toxicity of fenbuconazole in zebrafish: Effects on mitochondrial respiration and locomotor behavior	13
GenX induces fibroinflammatory gene expression in primary human hepatocytes	13
Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice	13
Bisphenols A, F, S and AF trigger apoptosis and/or endoplasmic reticulum stress in human endometrial stromal cells	13
Endocrine disrupting chemicals: Friend or foe to brown and beige adipose tissue?	13
Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity	13
Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation	13
Per- and polyfluoroalkyl substances (PFAS) augment adipogenesis and shift the proteome in murine 3T3-L1 adipocytes	13
Predicting the effects of per- and polyfluoroalkyl substance mixtures on peroxisome proliferator-activated receptor alpha activity in vitro	13
Toxicity evaluation of particles formed during 3D-printing: Cytotoxic, genotoxic, and inflammatory response in lung and macrophage models	13
Cadmium-stimulated invasion of rat liver cells during malignant transformation: Evidence of the involvement of oxidative stress/TET1-sensitive machinery	13
BDE-209 induce spermatocytes arrest at early-pachytene stage during meiotic prophase I in mice	13
Microcystin-leucine arginine exposure induced intestinal lipid accumulation and MC-LR efflux disorder in Lithobates catesbeianus tadpoles	13
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons	13
A hypoxia-driven occurrence of chronic kidney disease and osteoporosis in COPD individuals: New insights into environmental cadmium exposure	13
Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro	13
TCDD attenuates EAE through induction of FasL on B cells and inhibition of IgG production	12
The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis	12
Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes	12
Bisphenol-A exposure leads to neurotoxicity through upregulating the expression of histone deacetylase 2 in vivo and in vitro	12
L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neuroto	12
Tumour necrosis factor-α (TNF-α) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway	12
Cigarette smoke extract reduces FOXO3a promoting tumor progression and cell migration in lung cancer	12
Phytosphingosine-induced cell apoptosis via a mitochondrially mediated pathway	12
Human-relevant mechanisms and risk factors for TAK-875-Induced liver injury identified via a gene pathway-based approach in Collaborative Cross mice	12
Essential concepts for interpreting the dose-response of low-level arsenic exposure in epidemiological studies	12
Involvement of ABC transporters in the detoxification of non-substrate nanoparticles in lung and cervical cancer cells	12
Human CYP2E1-activated mutagenicity of dioxin-like PCBs 105 and 118—Experimental data consistent with molecular docking results	12
Association of endocrine disrupting chemicals levels in serum, environmental risk factors, and hepatic function among 5- to 14-year-old children	12
Aryl hydrocarbon receptor as a DNA methylation reader in the stress response pathway	12
Multiple neurological effects associated with exposure to organophosphorus pesticides in man	12
Cyclophosphamide instigated hepatic-renal oxidative/inflammatory stress aggravates immunosuppressive indoleamine 2,3-dioxygenase in male rats: Abatement by quercetin	12
Effect of fluoride on osteocyte-driven osteoclastic differentiation	12
Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats	12
Exposure to a combination of MWCNTs and DBP causes splenic toxicity in mice	12
Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells	12
Random forest algorithm-based accurate prediction of chemical toxicity to Tetrahymena pyriformis	11
The potential risks of chronic fluoride exposure on nephrotoxic via altering glucolipid metabolism and activating autophagy and apoptosis in ducks	11
Non-cytotoxic dosage of fumonisin B1 aggravates ochratoxin A-induced nephrocytotoxicity and apoptosis via ROS-dependent JNK/MAPK signaling pathway	11
Chronic exposure of bisphenol-A impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice	11
Enantioselective toxic effects of mefentrifluconazole in the liver of adult zebrafish (Danio rerio) based on transcription level and metabolomic profile	11
miR-138 inhibits epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by regulating ZEB2	11
NaF-induced neurotoxicity via activation of the IL-1β/JNK signaling pathway	11
Close association between the synergistic toxicity of zearalenone-deoxynivalenol combination and microRNA221-mediated PTEN/PI3K/AKT signaling in HepG2 cells	11
Alterations in reproductive parameters and steroid biosynthesis induced by nickel oxide nanoparticles in male rats: The ameliorative effect of hesperidin	11
Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis	11
Curcumin alleviates aristolochic acid nephropathy based on SIRT1/Nrf2/HO-1 signaling pathway	11
The immune modulatory role of marjoram extract on imidacloprid induced toxic effects in thymus and spleen of adult rats	11
L-carnitine extenuates endocrine disruption, inflammatory burst and oxidative stress in carbendazim-challenged male rats via upregulation of testicular StAR and FABP9, and downregulation of P38-MAPK p	11
Immunosuppression characterized by increased Treg cell and IL-10 levels in benzene-induced hematopoietic toxicity mouse model	11
Environmentally relevant perinatal exposure to DBP disturbs testicular development and puberty onset in male mice	11
In vitro toxicity of fibrous glaucophane	11
Sodium arsenite accelerates D-galactose-induced aging in the testis of the rat: Evidence for mitochondrial oxidative damage, NF-kB, JNK, and apoptosis pathways	11
Improvement roles of zinc supplementation in low dose lead induced testicular damage and glycolytic inhibition in mice	11
Sub-chronic exposure to Kalach 360 SL, Glyphosate-based Herbicide, induced bone rarefaction in female Wistar rats	11
An adverse outcome pathway on the disruption of retinoic acid metabolism leading to developmental craniofacial defects	11
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis	11
Physiologically inspired culture medium prolongs the lifetime and insulin sensitivity of human hepatocytes in micropatterned co-cultures	11
Development and characterization of rat duodenal organoids for ADME and toxicology applications	10
PM2.5 induces mitochondrial dysfunction via AHR-mediated cyp1a1 overexpression during zebrafish heart development	10
Autophagy-induced p62 accumulation is required for curcumol to regulate KLF5-mediated angiogenesis in liver sinusoidal endothelial cells	10
Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos	10
Neurotoxicity of zearalenone’s metabolites and beauvericin mycotoxins via apoptosis and cell cycle disruption	10
The role of DRP1- PINK1-Parkin-mediated mitophagy in early cadmium-induced liver damage	10
Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes	10
RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice	10
Toxicity mechanism of acrolein on DNA damage and apoptosis in BEAS-2B cells: Insights from cell biology and molecular docking analyses	10
Inhalation toxicity of copper compounds: Results of 14-day range finding study for copper sulphate pentahydrate and dicopper oxide and 28-day subacute inhalation exposure of dicopper oxide in rats	10
Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis	10
Estimating the potential toxicity of chiral diclofop-methyl: Mechanistic insight into the enantioselective behavior	10
Cytotoxicity and pro-inflammatory effect of polystyrene nano-plastic and micro-plastic on RAW264.7 cells	10
4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8	10
Melatonin ameliorates nickel induced autophagy in mouse brain: Diminution of oxidative stress	10
Acute oral colchicine caused gastric mucosal injury and disturbance of associated microbiota in mice	10
The methylimidazolium ionic liquid M8OI is detectable in human sera and is subject to biliary excretion in perfused human liver	10
Effects of low dose ionizing radiation on the brain- a functional, cellular, and molecular perspective	10
Single intratracheal administration of cross-linked water-soluble acrylic acid polymer causes acute alveolo-interstitial inflammation and the subsequent fibrotic formation possibly via the TGF-β1 path	10
HIF-1α inhibits T-2 toxin-mediated "immune evasion" process by negatively regulating PD-1/PD-L1	10
Evaluation and comparison of in vitro intrinsic clearance rates measured using cryopreserved hepatocytes from humans, rats, and rainbow trout	10
The potential mechanism of histamine-inducing cardiopulmonary inflammation and apoptosis in a novel oral model of rat intoxication	10
Nano-enabled delivery of EGCG ameliorates silica-induced pulmonary fibrosis in rats	10
Exosomes mediated the delivery of ochratoxin A-induced cytotoxicity in HEK293 cells	10
Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells	10
Mechanism-based identification of plasma metabolites associated with liver toxicity	10
The role of α5-nicotinic acetylcholine receptor/NLRP3 signaling pathway in lung adenocarcinoma cell proliferation and migration	10
Perinatal exposure to known endocrine disrupters alters ovarian development and systemic steroid hormone profile in rats	10
Oct4 plays a role in 2, 3, 7, 8 - tetrachlorobenzo-p-dioxin (TCDD) inducing cleft palate and inhibiting mesenchymal proliferation	9
Cadmium induced mouse spermatogonia apoptosis via mitochondrial calcium overload mediated by IP3R-MCU signal pathway	9
Effects of Deltamethrin Acute Exposure on Nav1.6 Channels and Medium Spiny Neurons of the Nucleus Accumbens	9
Phenanthrene induces autism-like behavior by promoting oxidative stress and mTOR pathway activation	9