OOIR: Observatory of International Research

Papers

(The H4-Index of Toxicology is 33. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats	201
Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease	126
Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice	115
A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®	112
Heavy metals induced mitochondrial dysfunction in animals: Molecular mechanism of toxicity	95
Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease	73
Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms	72
Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure	70
NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in swine	66
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells	54
The mechanism of the cadmium-induced toxicity and cellular response in the liver	54
Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro	54
AHR/ROS-mediated mitochondria apoptosis contributes to benzo[a]pyrene-induced heart defects and the protective effects of resveratrol	49
Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms	49
Effect of uncontrolled fertilization and heavy metal toxicity associated with arsenic(As), lead(Pb) and cadmium (Cd), and possible remediation	48
Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury	45
Vipers of Major clinical relevance in Europe: Taxonomy, venom composition, toxicology and clinical management of human bites	43
Safer chemicals using less animals: kick-off of the European ONTOX project	42
Paraquat exposure over generation affects lifespan and reproduction through mitochondrial disruption in C. elegans	41
ROS and iron homeostasis dependent ferroptosis play a vital role in 5-Fluorouracil induced cardiotoxicity in vitro and in vivo	38
Exposure to a mixture of heavy metals induces cognitive impairment: Genes and microRNAs involved	38
Phosgene inhalation toxicity: Update on mechanisms and mechanism-based treatment strategies	37
Aspirin eugenol ester ameliorates paraquat-induced oxidative damage through ROS/p38-MAPK-mediated mitochondrial apoptosis pathway	37
Environmental and occupational pesticide exposure and human sperm parameters: A Navigation Guide review	37
Nutrition, one-carbon metabolism and arsenic methylation	36

Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model	35
Oxaliplatin-induced hepatic sinusoidal obstruction syndrome	35
Inhibition of ferroptosis reduces susceptibility to frequent excessive alcohol consumption-induced atrial fibrillation	35
Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis	35
Alternative animal models in predictive toxicology	34
Ozone exposure promotes pyroptosis in rat lungs via the TLR2/4-NF-κB-NLRP3 signaling pathway	34
Mechanisms and treatment strategies of organophosphate pesticide induced neurotoxicity in humans: A critical appraisal	34
Cadmium induces apoptosis via generating reactive oxygen species to activate mitochondrial p53 pathway in primary rat osteoblasts	33
Cadmium induces endoplasmic reticulum stress-mediated apoptosis in pig pancreas via the increase of Th1 cells	33
Exposure to PM2.5 aggravates Parkinson’s disease via inhibition of autophagy and mitophagy pathway	33
Apoptotic activities of brusatol in human non-small cell lung cancer cells: Involvement of ROS-mediated mitochondrial-dependent pathway and inhibition of Nrf2-mediated antioxidant response	33