Acta Radiologica

Article	Citations
CT findings and dynamic imaging changes of COVID-19 in 2908 patients: a systematic review and meta-analysis	22
Imaging features of rhinocerebral mucormycosis: from onset to vascular complications	21
Ultrasound-guided transperineal laser ablation for percutaneous treatment of benign prostatic hyperplasia: a new minimally invasive interventional therapy	21
Pirarubicin-loaded CalliSpheres® drug-eluting beads for the treatment of patients with stage III–IV lung cancer	19
Radiomics and machine learning to predict aggressive type 2 endoleaks after endovascular aneurysm repair: a proof of concept	18
Additional value of deep learning computed tomographic angiography-based fractional flow reserve in detecting coronary stenosis and predicting outcomes	18
Highlights of the development in ultrasound during the last 70 years: A historical review	17
Predicting 1p/19q codeletion status using diffusion-, susceptibility-, perfusion-weighted, and conventional MRI in IDH-mutant lower-grade gliomas	15
Identifying cardiomegaly in chest X-rays: a cross-sectional study of evaluation and comparison between different transfer learning methods	14
Association between cardiovascular risk factors and degenerative disc disease of the thoracolumbar spine in the general population: results from the KORA MRI Study	13
Diagnostic accuracy of ultra-low-dose chest computed tomography in an emergency department	12
Imaging diagnosis for anterior talofibular ligament injury: a systemic review with meta-analysis	12
Measuring functional connectivity in patients with strabismus using stationary functional magnetic resonance imaging: a resting-state network study	11
Role of MRI in idiopathic inflammatory myopathies: a review article	11
Computed tomography characteristics of multiple myeloma and other osteolytic metastatic bone lesions	11
Multiparametric MRI-based radiomics analysis: differentiation of subtypes of cervical cancer in the early stage	10
Prediction of transarterial chemoembolization refractoriness in patients with hepatocellular carcinoma using imaging features of gadoxetic acid-enhanced magnetic resonance imaging	10
Impact of dual-energy 50-keV virtual monoenergetic images on radiologist confidence in detection of key imaging findings of small hepatocellular carcinomas using multiphase liver CT	10
Diagnostic accuracy and validity of the O-RADS MRI score based on a simplified MRI protocol: a single tertiary center retrospective study	9
Cognitive impairment in mild traumatic brain injury: a diffusion kurtosis imaging and volumetric study	9
Pregnancy-related sacroiliac joint findings in females with low back pain: a four-year magnetic resonance imaging follow-up study	9
Percutaneous transcystic removal of gallbladder and common bile duct stones: a narrative review	9
Radiomics-based machine learning models for prediction of medulloblastoma subgroups: a systematic review and meta-analysis of the diagnostic test performance	9
Machine learning for lung texture analysis on thin-section CT: Capability for assessments of disease severity and therapeutic effect for connective tissue disease patients in comparison with expert pa	8
Preoperative planning of total knee arthroplasty: reliability of axial alignment using a three-dimensional planning approach	8

Detecting lymph node metastasis of esophageal cancer on dual-energy computed tomography	8
CT radiomics models are unable to predict new liver metastasis after successful thermal ablation of colorectal liver metastases	8
Differential diagnosis of renal oncocytoma and chromophobe renal cell carcinoma using CT features: a central scar-matched retrospective study	8
Does ARFI elastography complement B-mode ultrasonography in the radiological diagnosis of idiopathic granulomatous mastitis and invasive ductal carcinoma?	8
Radiation-associated angiosarcoma of the breast: analysis of diagnostic tools in a registry-based population	8
Predictive value of time-variant color-coded multiphase CT angiography (mCTA) regarding clinical outcome of acute ischemic stroke: in comparison with conventional mCTA and CT perfusion	8
Clinical value of O-RADS combined with serum CA125 and HE4 for the diagnosis of ovarian tumours	7
Prediction of the number of metastatic axillary lymph nodes in breast cancer by radiomic signature based on dynamic contrast-enhanced MRI	7
Comparison of malignant calcification identification between breast cone-beam computed tomography and digital mammography	7
Quantitative breast density measurement based on three-dimensional images: a study on cone-beam breast computed tomography	7
Diagnostic value of conventional ultrasound and shear wave elastography in detecting transjugular intrahepatic portosystemic shunt dysfunction	7
Different chest CT scoring systems in patients with COVID-19: could baseline CT be a helpful tool in predicting survival in patients with matched ages and co-morbid conditions?	7
Predicting the clinically significant subscapularis tendon tear: malposition and tear of the long head of the biceps tendon on shoulder magnetic resonance imaging	7
Evaluation of femoral head bone quality by Hounsfield units: a comparison with dual-energy X-ray absorptiometry	7
A comparative study of four diffusion-weighted imaging models in the diagnosis of cervical cancer	7
Radiomics and stacking regression model for measuring bone mineral density using abdominal computed tomography	7
Diagnostic performance and image quality of deep learning image reconstruction (DLIR) on unenhanced low-dose abdominal CT for urolithiasis	7
Apparent diffusion coefficients (ADC) in response assessment of transarterial radioembolization (TARE) for liver metastases of neuroendocrine tumors (NET): a feasibility study	7
MRI features of responsible contacts in vascular compressive trigeminal neuralgia and prediction modeling	7
Endometrial cancer: the role of MRI quantitative assessment in preoperative staging and risk stratification	7
Multidetector computed tomography in diagnosing peritoneal metastases in ovarian carcinoma	7
Does the primary soft-tissue sarcoma configuration predict configuration of recurrent tumors on magnetic resonance imaging?	6
Venous stent versus conventional stent for the treatment of central vein obstruction in hemodialysis patients: a retrospective study	6
Optimal sequences and sequence parameters for GBCA-enhanced MRI of the glymphatic system: a systematic literature review	6
PET/MR versus PET/CT for locoregional staging of oropharyngeal squamous cell cancer	6
Predictors of favorable outcome after endovascular thrombectomy for acute ischemic stroke due to large vessel occlusion in young patients	6
Diagnostic performance of imaging features in the HBP of gadoxetate disodium-enhanced MRI for microvascular invasion in hepatocellular carcinoma: a meta-analysis	6
Radiomics analysis enables fatal outcome prediction for hospitalized patients with coronavirus disease 2019 (COVID-19)	6
Whole-tumor histogram analysis of apparent diffusion coefficient for differentiating adenosquamous carcinoma and adenocarcinoma from squamous cell carcinoma in patients with cervical cancer	6
Acute and subacute prostate MRI findings after MRI-guided transurethral ultrasound ablation of prostate cancer	6
Diagnosis of Menière’s disease on MRI: feasibility at 1.5 Tesla	6
Magnetic resonance imaging characteristics of chronic prostatitis in patients under the age of 50: is it more than the eye can see?	6
Total and regional ASPECT score for non-contrast CT, CT angiography, and CT perfusion: inter-rater agreement and its association with the final infarction in acute ischemic stroke patients	6
Axial loading during supine MRI for improved assessment of lumbar spine: comparison with standing MRI	6
Transrectal ultrasound features and biopsy outcomes of transition PI-RADS 5	6
Diagnostic performance of 18F-labeled PSMA PET/CT in patients with biochemical recurrence of prostate cancer: a systematic review and meta-analysis	6
Thrombectomy of symptomatic isolated occlusions of posterior cerebral arteries in segment P1 and P2 in acute stroke treatment	6
Differentiation of lacrimal gland tumors using the multi-model MRI: classification and regression tree (CART)-based analysis	6
Evaluating intracranial artery dissection by using three-dimensional simultaneous non-contrast angiography and intra-plaque hemorrhage high-resolution magnetic resonance imaging: a retrospective study	6
The development of musculoskeletal radiology for 100 years as presented in the pages of Acta Radiologica	5
Predictive value of intravoxel incoherent motion combined with diffusion kurtosis imaging for breast cancer axillary lymph node metastasis: a retrospective study	5
The clinical value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) semi-quantitative parameters in monitoring neoadjuvant chemotherapy response of osteosarcoma	5
Automatic diagnosis and grading of patellofemoral osteoarthritis from the axial radiographic view: a deep learning-based approach	5
Multimodal functional imaging for early response assessment in patients with gastrointestinal stromal tumor treated with tyrosine kinase inhibitors	5
A computed tomography-based radiomic nomogram for predicting lymph node metastasis in patients with early-stage papillary thyroid carcinoma	5
The diagnostic value of cranial MRI findings in idiopathic intracranial hypertension: evaluating radiological parameters associated with intracranial pressure	5
Is 2D SWE sufficient as clinical diagnosis in patients with plantar fasciitis?	5
Transcatheter arterial embolization of iatrogenic massive arterioportal fistula in the liver	5
Standardize routine angiography assessment of leg vasculatures before fibular flap harvest: lessons of congenital and acquired vascular anomalies undetected by color Doppler and physical examinations	5
Usefulness of computed tomography in the diagnosis of acute pyelonephritis in older patients suspected of infection with unknown focus	5

Peripheral and central smell regions in COVID-19 positive patients: an MRI evaluation	5
The utility of diffusion-weighted imaging and ADC values in the characterization of mumps orchitis and seminoma	5
Diagnostic value of mammography for accompanying non-mass enhancement on preoperative breast MRI	5
Efficacy and tolerability of chemosaturation in patients with hepatic metastases from uveal melanoma	5
Ancillary findings in distinguishing between anterior cruciate ligament mucoid degeneration and sprain on MRI: a practical approach	5
Vascular anomalies: nomenclature, classification, and imaging algorithms	5
Feasibility of ultrashort echo time (UTE) T2* cartilage mapping in the hip: a pilot study	5
Distribution of pressure on the breast in mammography using flexible and rigid compression plates: implications on patient handling	5
The diagnostic value of T2 map, diffusion tensor imaging, and diffusion kurtosis imaging in differentiating dermatomyositis from muscular dystrophy	5
Overnight radiology resident discrepancies at a large pediatric hospital: categorization by year of training, program, imaging modality, and report type	5
Multimodal ultrasound parameters aided carotid plaque risk stratification in patients with asymptomatic carotid stenosis	5
Radiologic findings and the molecular expression profile of diffuse midline glioma H3 K27M mutant	5
Long-term integrity of 53 iliac vein stents after catheter-directed thrombolysis	5
Shear wave elastography evaluation of brachial plexus in multiple sclerosis	5
Quantitative assessment of the intraorbital segment of the optic nerve in patients with thyroid orbitopathy using diffusion tensor imaging	5
The diagnosis of early pneumoconiosis in dust-exposed workers: comparison of chest radiography and computed tomography	5
Generative adversarial network-based post-processed image super-resolution technology for accelerating brain MRI: comparison with compressed sensing	5
Visualization of wrist ligaments with 3D and 2D magnetic resonance imaging at 3 Tesla	5
Preferred music lowers anxiety levels and pain perception while promoting patient satisfaction in women undergoing ultrasound-guided breast biopsy: randomized controlled study	5
Intra- and inter-rater reliability for the measurement of the cross-sectional area of ankle tendons assessed by magnetic resonance imaging	5
Differential diagnosis of fibroma of tendon sheath and giant cell tumor of tendon sheath in the finger using signal intensity on T2 magnetic resonance imaging	5
Deep learning nomogram for predicting lymph node metastasis using computed tomography image in cervical cancer	5
High riding jugular bulb: prevalence and significance in asymptomatic children	4
Knee anatomic geometry accurately predicts risk of anterior cruciate ligament rupture	4
Cerebral blood volume Alberta Stroke Program Early Computed Tomography Score predicts intracranial hemorrhage after thrombectomy in patients with acute ischemic stroke in an extended time window	4
BLADE turbo gradient- and spin-echo in the assessment of sinonasal lesions: a comprehensive comparison of image quality in readout-segmented echo-planar imaging	4
A novel food-based foam as oral contrast agent with negative Hounsfield units for demarcation of small bowel loops on abdominal CT: tolerability and bowel distension in 25 volunteers	4
Transcatheter arterial embolization for massive hemobilia with N-butyl cyanoacrylate (NBCA) Glubran 2	4
Staff dose evaluation by application of radiation protection during endoscopic retrograde cholangiopancreatography (ERCP) procedures performed with a mobile C-arm	4
Investigation of changes in activity and function in acute unilateral open globe injury–associated brain regions based on percent amplitude of fluctuation method: a resting-state functional MRI study	4
T1rho, T2, and T2* relaxation time based on grading of intervertebral disc degeneration	4
The investigation of reduced field-of-view diffusion-weighted imaging (DWI) in patients with nasopharyngeal carcinoma: comparison with conventional DWI	4
The development of breast radiology: the Acta Radiologica perspective	4
Managing patients with suspected postpartum retained products of conception using a novel sonographic classification	4
Measuring pure ground-glass nodules on computed tomography: assessing agreement between a commercially available deep learning algorithm and radiologists’ readings	4
Prospective comparison of magnetic resonance imaging and computed tomography in diagnosing occult scaphoid fractures	4
Multireader image quality evaluation of dynamic myocardial computed tomography perfusion imaging with a novel four-dimensional noise reduction filter	4
Contrast medium protocols in routine chest CT: a survey study	4
Coronary artery calcium quantification: comparison between filtered-back projection, hybrid iterative reconstruction, and deep learning reconstruction techniques	4
Predicting ureteral status below the ureteral calculi in patients undergoing ureteroscopic lithotomy	4
Impairment of motor skills in children with achondroplasia—usefulness of brain and cranio-cervical junction evaluation by quantitative magnetic resonance imaging: a case-control study	4
Can optimized model-based iterative reconstruction improve the contrast of liver lesions in CT?	4
Utility of intraoperative magnetic resonance imaging for giant cell tumor of bone after denosumab treatment: a pilot study	4
Radiology reporting in rectal cancer using MRI: adherence to national template for structured reporting	4
The diagnostic efficiency of the perfusion-related parameters in assessing the vascular disrupting agent (CA4P) response in a rabbit VX2 liver tumor model	4
Latest diagnostic performance of different ultrasonic features for biliary atresia	4
Deep learning reconstruction allows for usage of contrast agent of lower concentration for coronary CTA than filtered back projection and hybrid iterative reconstruction	4
Diffusion kurtosis imaging assessment of the response to radiotherapy in a VX2 bone tumor model: an animal study	4
Evaluation of extraocular muscles in patients with thyroid associated ophthalmopathy using apparent diffusion coefficient measured by magnetic resonance imaging before and after radiation therapy	4
CT-based radiomics signature to predict CD8+ tumor infiltrating lymphocytes in non-small-cell lung cancer	4
Percutaneous retrieval of intravascular foreign body in children: a case series and review	4
Emergence of teleradiology, PACS, and other radiology IT solutions in Acta Radiologica	4
Disrupted dynamic pattern of regional neural activity in early-stage cognitively normal Parkinson's disease	4
Enhanced visualization of mobile chest X-ray images in the intensive care setting using software scatter correction	4
Variations ignored in routine wrist MRI reports: prevalence of the median nerve anatomical variations and persistent median artery	4
COVID-19 myocarditis cardiac magnetic resonance findings in symptomatic patients	4
The diagnostic accuracy of intravoxel incoherent motion and diffusion kurtosis imaging in the differentiation of malignant and benign soft-tissue masses: which is better?	4
Multiparametric MRI-based radiomics for the prediction of microvascular invasion in hepatocellular carcinoma	4
Subtyping of hepatocellular adenomas using Gd-EOB-DTPA: a qualitative and quantitative analysis	4
Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma	4
Radiomic analysis of preoperative magnetic resonance imaging for the prediction of pituitary adenoma consistency	4
Correlation between characteristics of intracranial atherosclerotic plaques and ischemic stroke in high-resolution vascular wall MRI	4
Virtual versus true non-contrast images of the brain from spectral detector CT: comparison of attenuation values and image quality	4
Clinical evaluation of AI software for rib fracture detection and its impact on junior radiologist performance	4
Radiomics model based on intravoxel incoherent motion and diffusion kurtosis imaging for predicting histopathological grade and Ki-67 expression level of soft tissue sarcomas	4
Diagnostic outcome and safety of plugged liver biopsy in high-risk patients: a systematic review and meta-analysis	3
Increased muscle fiber fractional anisotropy value using diffusion tensor imaging after compression without fiber injury	3
Correlation between the subchondral bone marrow lesions and cartilage repair tissue after matrix-associated autologous chondrocyte implantation in the knee: a cross-sectional study	3
Uterine artery embolization for postpartum hemorrhage with placenta accreta spectrum	3
Postoperative progression of intracranial grade II–III solitary fibrous tumor/hemangiopericytoma: predictive value of preoperative magnetic resonance imaging semantic features	3
The history of magnetic resonance imaging and its reflections in Acta Radiologica	3
Effects of tube voltage and iodine contrast medium on radiation dose of whole-body CT	3
Morphological changes in the pons and cerebellum during the first two weeks in term infants with pontine and cerebellar injury and profound neonatal asphyxia	3
Comparison of metal artifact reduction techniques in magnetic resonance imaging of carbon-reinforced PEEK and titanium spinal implants	3
Medical applications of generative adversarial network: a visualization analysis	3
Computed tomography radiomics to predict EBER positivity in Epstein–Barr virus-associated gastric adenocarcinomas: a retrospective study	3
Magnetic resonance imaging as a first-choice imaging modality in carpal tunnel syndrome: new evidence	3
Diagnostic performance of T2-weighted imaging and intravoxel incoherent motion diffusion-weighted MRI for predicting metastatic axillary lymph nodes in T1 and T2 stage breast cancer	3
CT-based radiomics to distinguish progressive from stable neuroendocrine liver metastases treated with somatostatin analogues: an explorative study	3
Trends in contrast media research the last 100 years	3

Diagnostic performance of MRI and endoscopy for assessing complete response in rectal cancer after neoadjuvant chemoradiotherapy: a systematic review of the literature	3
Grading of clear cell renal cell carcinoma using diffusion MRI with a fractional order calculus model	3
Trabecular bone microstructure analysis on data from a novel twin robotic X-ray device	3
Quantitative differentiation of tendon and ligament using magnetic resonance imaging ultrashort echo time T2* mapping of normal knee joint	3
Role of digital tomosynthesis in the context of tuberculosis contact investigation: comparisons with digital radiography	3
Alterations of static and dynamic functional network connectivity in acute ischemic brainstem stroke	3
Soft tissue sarcoma: intravoxel incoherent motion and diffusion kurtosis imaging parameters correlate with the histological grade and Ki-67 expression	3
The prevalence of sacroiliitis on abdominal MRI examinations of patients with Takayasu arteritis	3
Reproducibility of pulmonary magnetic resonance angiography in adults with muco-obstructive pulmonary disease	3
MRI findings of ischiofemoral impingement after total hip arthroplasty are associated with increased femoral antetorsion	3
Value of energy spectrum CT parameters in the differential diagnosis of high-grade clear cell renal cell carcinoma and type II papillary renal cell carcinoma	3
Deep learning-based noise reduction for coronary CT angiography: using four-dimensional noise-reduction images as the ground truth	3
Automated ASPECTS in acute ischemic stroke: comparison of the overall scores and Hounsfield unit values of two software packages and radiologists with different levels of experience	3
Brain MRI features of anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis secondary to central nervous system infection in adult patients	3
Value of pre-intervention computed tomography perfusion imaging in the assessment of tissue outcome and long-term clinical prognosis in patients with anterior circulation acute ischemic stroke receivi	3
Comparison and verification of two deep learning models for the detection of chest CT rib fractures	3
Retrosternal hematoma in sternal fracture for prediction of concomitant injury on chest CT	3
T1 mapping is useful for staging deep venous thrombosis in the lower extremities	3
The influence of artificial intelligence assistance on the diagnostic performance of CCTA for coronary stenosis for radiologists with different levels of experience	3
Peritumoral portal enhancement during transarterial chemoembolization: a potential prognostic factor for patients with hepatocellular carcinoma	3
Is radiological rotation measurement affected by the fracture pattern in pediatric supracondylar humeral fractures?	3
Aberrant changes of dynamic global synchronization in patients with Parkinson's disease	3
Pelvic tilt impacts cup orientation on CT: how accurate is the gold standard?	3
Acetabular cartilage delamination: performance of MRI using arthroscopy as the standard of reference	3
The effect of living at high altitude on carotid intima-media thickness in the elderly: a comparative study	3
Effect of “drip-and-ship” and “drip-and-drive” on endovascular treatment of acute ischemic stroke with large vessel occlusion: a single-center retrospective study	3
Changes in apparent diffusion coefficient and pathological response in colorectal liver metastases after preoperative chemotherapy	3
Comparison of MRI and CT-based radiomics for preoperative prediction of lymph node metastasis in pancreatic ductal adenocarcinoma	3
Higher magnetic susceptibility of globus pallidus in patients after macrocyclic GBCAs: assessment using quantitative susceptibility mapping	3
Utility of combined gadoxetic acid and ferumoxytol-enhanced liver MRI for preoperative detection of colorectal cancer liver metastases: a pilot study	3
Evaluation of the relationship between placental stiffness measured by shear wave elastography and perinatal outcomes in women with gestational diabetes mellitus	3
Evaluation of response in patients with hepatocellular carcinoma treated with intratumoral dendritic cell vaccination using intravoxel incoherent motion (IVIM) MRI and histogram analysis	3
Impact of iodinated contrast media concentration on image quality for dual-energy CT and single-energy CT with low tube voltage settings	3
Implementation of abbreviated breast MRI in diagnostic and screening settings	3
Diagnostic yield and safety of percutaneous CT-guided biopsy of retroperitoneal lesions and analysis of imaging features	3
Estimation of sex from computed tomography images of skull measurements in an adult Turkish population	3
Safety and efficacy of MRI-guided transurethral ultrasound ablation for radiorecurrent prostate cancer in the presence of gold fiducial markers	3
Ultrasound-stimulated microbubbles enhances radiosensitivity of ovarian cancer	3
Multi-echo Dixon and breath-hold T2-corrected multi-echo single-voxel MRS for quantifying hepatic iron overload in rabbits	3
Preoperative prediction of lymphovascular space invasion in endometrioid adenocarcinoma: an MRI-based radiomics nomogram with consideration of the peritumoral region	3
Is the Femoral-Epiphyseal Acetabular Roof (FEAR) index associated with hip pain in patients with hip dysplasia?	3
Factors associated with brain white matter damage in type 2 diabetes mellitus: a tract-based spatial statistics study	3
Non-ECG-gated high-pitch CT angiography versus hybrid ECG-gated CT angiography for aorta using 512-slice CT: comparison of image quality and radiation dose	3
Musculoskeletal symptoms among radiation technologists in Saudi Arabia: prevalence and causative factors	3
Accuracy of iodine quantification using dual-energy computed tomography with focus on low concentrations	3
A new alternative technique for the guidance of transjugular intrahepatic portosystemic shunt creation using DSA overlay reference	3
3D zero-echo time and 3D T1-weighted gradient-echo MRI sequences as an alternative to CT for the evaluation of the lumbar facet joints and lumbosacral transitional vertebrae	3
Dynamic contrast-enhanced MRI perfusion parameters are imaging biomarkers for angiogenesis in lung cancer	3
Deep learning for automatic segmentation of paraspinal muscle on computed tomography	3
Shear-wave elastography for detection of placenta percreta: a case-controlled study	3
Association of total cerebral small vessel disease burden with the cavitation of recent small subcortical infarcts	3
Establishment of diagnostic reference levels in low-dose renal computed tomography	3
Diagnostic accuracy of point-of-care knee ultrasound for evaluation of meniscus and collateral ligaments pathology in comparison with MRI	3
Effect of image quality on myocardial extracellular volume quantification using cardiac computed tomography: a phantom study	3
Diagnostic value of susceptibility-weighted imaging for endometrioma: preliminary results from a retrospective analysis	3
Assessment of association between the carotid web and dissection in spontaneous internal carotid artery dissection patients using vessel wall MRI	3
Usefulness of subtraction images for accurate diagnosis of pituitary microadenomas in dynamic contrast-enhanced magnetic resonance imaging	3
Prediction of central compartment nodal metastases in papillary thyroid cancer using TI-RADS score, blood flow, and multifocality	3
Full core technology versus notch sampling technology: evaluation of the diagnostic accuracy and the risk of a pneumothorax after transthoracic needle biopsy of suspicious lung lesions	3
The diagnosis performance of convolutional neural network in the detection of pulmonary nodules: a systematic review and meta-analysis	3
Ultrasound-guided perineal laser ablation versus prostatic arterial embolization for benign prostatic hyperplasia: two similar short-term efficacies	3
Myocardial uptake of 68Ga-DOTATATE: correlation with cardiac disease and risk factors	3
Safety, efficacy, and mid-term oncological outcomes of computed tomography-guided cryoablation of T1 renal cancer	3