Regulatory Toxicology and Pharmacology

Article	Citations
Target organ toxicity in Sprague Dawley rats following oral exposure to complex groundwater mixture: Assessment of dose-response relationships using histopathological and biochemical alterations	122
A review of common approaches to determining allocation factors and relative source contribution factors for drinking water contaminants: caveats and areas for improvement	83
Two-year carcinogenicity study of a novel plasticizer, bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate (Eco-DEHCH), by oral diet in Han Wistar rats	81
Prevalence and sample sizes in pre-clinical studies	75
Selectively addressing total risk avoidance for certain chemicals while overlooking others: The case of per-and-poly-fluoroalkyls	75
Preclinical safety evaluation of the ethanolic extract from the aerial parts of Gomphrena celosioides Mart. in rodents	68
Controlling cleaning agent residues in pharmaceutical manufacturing: A harmonized scientific strategy	67
Is periventricular heterotopia a useful endpoint for developmental thyroid hormone system disruption in mouse toxicity studies?	57
Safety evaluation of ondansetron after gestational exposure on male reproductive parameters in rats	57
Ames mutagenicity of 15 aryl, benzyl, and aliphatic ring N-nitrosamines	52
Risk Assessment and Pharmacokinetic Modeling of Incidental Ingestion of Ethanol from Mouthwash	51
Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs)	49
A Cautionary tale for using read-across for cancer hazard classification: Case study of isoeugenol and methyl eugenol	47
Control of N-nitrosamine impurities in drug products: Progressing the current CPCA framework and supporting the derivation of robust compound specific acceptable intakes	42
HESI GTTC ring trial: Concordance between Ames and rodent carcinogenicity outcomes for N-nitrosamines (NAs) with rat and hamster metabolic conditions	41
Incorporating Singaporean habits and practices for cosmetics and personal care products into a global consumer aggregate exposure model	39
Decision making in next generation risk assessment for skin allergy: Using historical clinical experience to benchmark risk	38
Acute dose toxicity evaluation of the food supplement calcium 3-hydroxy-3-methylbutyrate (HMB) in female Sprague Dawley rats	37
Importance of tailored non-clinical safety testing of novel antimalarial drugs: Industry best-practice	36
Toltrazuril sulfone (Ponazuril) residue depletion in pig tissues and estimated withdrawal intervals	35
Apparent Khat chewers exposure to DDT in Ethiopia and its potential toxic effects: A scoping review	34
Editorial: 2024 - A promising start for regulatory toxicology and pharmacology	34
Editorial Board	33
Results from two-year rodent oral carcinogenicity studies of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator	32
False positive findings associated with adenoviral vector-based vaccine underscore the regulatory necessity to eliminate abnormal toxicity test	32

Scientific considerations in the regulatory approval of generic (or biosimilar) version of enoxaparin sodium – A lifesaving carbohydrate polymer	32
Editorial Board	32
Editorial Board	30
Expert panel evaluation of the tumor modes of action for 1,4-dioxane and their implications for human risk assessment	30
Exploring the potential of ToxCast™ data for mechanism-based prioritization of chemicals in regulatory context: Case study with priority existing chemicals (PECs) under K-REACH	30
Safety data sheets as an information pathway on hazards of occupationally used cleaning agents	29
A tool to support food substance safety evaluations in the United States	29
Physiologically based pharmacokinetic modeling of oseltamivir in pregnant rhesus macaques to inform clinical dosing across trimesters	29
Editorial Board	28
Updated interim reference levels for dietary lead to support FDA's Closer to Zero action plan	28
Mapping new psychoactive substances: Leveraging GIS technology for advanced global surveillance and policy support	25
Editorial Board	24
Letter to the editors regarding “Inter-laboratory validation of bioaccessibility testing for metals” by Henderson et al. (2014)	24
Commentary: Value of information case study strongly supports use of the Threshold of Toxicological Concern (TTC)	24
Computational prediction of Calu-3-based in vitro pulmonary permeability of chemicals	23
Editorial Board	23
Evaluating H295R steroidogenesis assay data for robust interpretation	23
Effects of glucokinase activator, DS-7309, on embryo-fetal developmental toxicity in rats and rabbits	22
Case study on the impact of the source of metabolism parameters in next generation physiologically based pharmacokinetic models: Implications for occupational exposures to trimethylbenzenes	21
Preclinical safety assessment of toxicity and biodistribution of oncolytic virus HSV-1 expressing human PD-1 antibody in mice	21
Commentary on FDA's shift from animal testing and implications for drug attrition – The time to act is now	21
Deriving acceptable limits for non-mutagenic impurities in medicinal products – Durational adjustments	21
Subchronic toxicity study of ferric oxide nanoparticles through intragastric administration: A 94-d, repeated dose study in Sprague Dawley rats	21
Feasibility study for a downsized comparative thyroid assay with measurement of brain thyroid hormones and histopathology in rats: Case study with 6-propylthiouracil and sodium phenobarbital at high d	21
Human exposure to toxic elements through facial cosmetic products: Dermal risk assessment	21
Evaluation of the EMA log kow trigger for fish BCF testing based on data for several human pharmaceuticals	20
Retrospective evaluation of the use of non-human primates for fertility assessment of pharmaceuticals submitted for marketing approval in the EU	20
Measured air concentrations of pesticides for the estimation of exposure to vapour in European risk assessments	20
Prioritizing of potential environmental exposure carcinogens beyond IARC group 1–2B based on weight of evidence (WoE) approach	19
Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop	19
Investigating the uncertainty of prediction accuracy for the application of physiologically based pharmacokinetic models to animal-free risk assessment of cosmetic ingredients	19
The safety of monosodium glutamate demonstrated in 28-day and 90-day dietary toxicity studies with Sprague-Dawley rats	19
Evaluating the lifetime cumulative dose as a basis for carcinogenic potency of nitrosamines – a key tenet underpinning less-than-lifetime approaches for establishing acceptable intake limits	19
The value of a structured, systematic approach to benefit-risk assessment of medicines: A South African regulator case study	18
Towards achieving a modern science-based paradigm for agrochemical carcinogenicity assessment	17
Safe usage levels of aqueous Hippophae rhamnoides fruit extract in cosmetics estimated by threshold of toxicological concern, point of departure, and history of safe consumption	17
Evaluating cancer risks: The impact of thirdhand smoke exposure on carcinogenesis	17
Safety assessment for nail cosmetics: Framework for the estimation of systemic exposure through the nail plate	17
Letter to the Editors regarding “10% body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis”	17
Non-animal approaches for photoallergenicity safety assessment: Needs and perspectives for the toxicology for the 21st century	17
Evaluating scientific confidence in the concordance of in vitro and in vivo protective points of departure	16
Dose level selection for developmental and reproductive toxicology (DART) studies: Insights from the EUROTOX 2024 satellite workshop	16
Assessment of endocrine disruptors in the European Union: Current regulatory framework, use of new approach methodologies (NAMs) and recommendations for improvements	16
Randomized, triple-blind, placebo-controlled study to evaluate the safety of 6′-Sialyllactose in healthy adults	16
Research on 90-day subchronic toxicities of the ethanol extract from the cultivated Fritillaria Cirrhosa bulbs by oral administration in Sprague-Dawley rats	16
Derivation of no significant risk levels for three lower acrylates: Conclusions and recommendations from an expert panel	16
Modeling extraction of medical device polymers for biocompatibility evaluation	15
Rodent estrous cycle pattern: Harmonizing the cycle evaluation and interpretation	15
Exposure and disease burden of fumonisins and aflatoxins from sorghum consumption in Ethiopia	15
The purity of tattoo inks, screening substances of high concern	15

Benchmarking performance of SENS-IS assay against weight of evidence skin sensitization potency categories	15
Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays	15
Report on the European Partnership for Alternative Approaches to Animal Testing (EPAA) “New Approach Methodologies (NAMs) User Forum Kick-Off Workshop”	15
Calculated cancer risks for polycyclic aromatic hydrocarbon mixtures in mainstream smoke of cigarettes sold in China	15
Dealing with substances with no defined molecular weight in non-animal assays for skin sensitization. A comment on “Plant extracts, polymers and new approach methods: Practical experience with skin se	14
Letter to the Editor: Modeling the changing face of Phosphatidylethanol's window of detection	14
Quantitative measurement of harmful and potentially harmful constituents, pH, and moisture content in 16 commercial smokeless tobacco products	14
A comparison between field measurements of vapour concentrations of plant protection products and predictions by the BROWSE model	14
Residue depletion profiles and withdrawal interval estimations of meloxicam in eggs and ovarian follicles following intravenous (Meloxicam solution for injection) and oral (Meloxidyl®) administration	14
A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 2 b: Reactive cobalt substances induce oxidative stress in ToxTracker and activate hypoxia target genes	14
In vivo screening evaluation of 12 chemicals as candidate endocrine disruptors using ovariectomized mouse uterotrophic bioassay	14
N-Nitrosamine drug substance related impurities (NDSRIs) – A proposal for the addition of subcategories to carcinogenic potency categorization approach categories 1 and 2 for NDSRIs with a molecular w	13
Can next generation ecological risk assessment decisions be made today?―A case study of regulatory risk assessment in the United States	13
Rebuttal to the letter to the editors regarding Van Berlo et al. (2022) paper titled “10% Body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis”	13
Reply to Comment on “Reduced specificity for the local lymph node assay for lipophilic chemicals: Implications for the validation of new approach methods for skin sensitization” by Roberts and Baskett	13
N-nitrosamine impurity risk assessment in pharmaceuticals: Utilizing In vivo mutation relative potency comparison to establish an acceptable intake for NTTP	13
Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database	13
Absence of developmental or reproductive toxicity in rats for MB-102, a fluorescent tracer agent for point-of-care measurement of glomerular filtration rate	13
Cancer weight of evidence for three lower acrylates: Conclusions and recommendations from an expert panel	13
Integration of toxicodynamic and toxicokinetic new approach methods into a weight-of-evidence analysis for pesticide developmental neurotoxicity assessment: A case-study with DL- and L-glufosinate	13
Unknown confidence in chemical characterization identification levels: When tentative identifications are adequate for toxicological risk assessment of medical devices	13
Considerations regarding the use of nonhuman primates in assessing safety endpoints for pharmaceuticals	12
A scheme to evaluate structural alerts to predict toxicity – Assessing confidence by characterising uncertainties	12
A new method of consistency evaluation of brain drugs: a case study of edaravone	12
Corrigendum to “Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products” [Regul. Toxicol. Pharmacol. 72 3 (2015) 673-68]	12
Regulatory performance of the East African Community joint assessment procedure: The way forward for regulatory systems strengthening	12
Exploring the link: DNA methylation and kidney injury markers in farmers exposed to glyphosate-surfactant herbicides	12
Acute and sub-acute toxicity assessment of methanolic extract from Clerodendrum infortunatum flowers	12
Points to consider for revising the ICH S7A guideline on safety and secondary pharmacology	12
Development of a digital tool for semi-quantitative assessment of pesticide exposure risk in greenhouses	12
Six-well plate-based colony-forming efficacy assay and Co-Culture application to assess toxicity of metal oxide nanoparticles	12
Comprehensive extractables and leachables sensitization analysis and practical application of a risk-based approach to sensitization assessment for parenteral drug products	12
The Botanical Safety Consortium: A public-private partnership to enhance the botanical safety toolkit	11
Toxicity reference values for force health protection: Provisional occupational exposure guidelines	11
Use of physiologically based pharmacokinetic modeling to support development of an acute (24-hour) health-based inhalation guideline for manganese	11
In silico predictions of absorption of MDI substances after dermal or inhalation exposures to support a category based read-across assessment	11
Carcinogenicity testing in drug development: Getting it right	11
Contributions of the joint FAO/WHO expert committee on food additives to international food safety: celebrating the 100th meeting of the committee	11
Safety and regulatory assessment of heat-killed Lactiplantibacillus plantarum strain L-137 (HK L-137) as a food ingredient	11
Evaluating the applicability of the Ames test for cosmetic packaging assessment by comparing carcinogenic risk levels of migrants from plastics with biological detection limits	11
Evaluation of good review practices at the Food and Drugs Authority of Ghana as it strives to become a World Health Organization-listed agency	11
Systematic review of the potential carcinogenicity of bisphenol A in humans	11
R-ODAF: Omics data analysis framework for regulatory application	11
Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey	11
Editorial Board	11
Analysis of non-mutagenic substances in the context of drug impurity assessment – Few are potent toxicants	11
Evaluating dermal absorption of perfluorooctanoic acid (PFOA) and implications for other per- and polyfluoroalkyl substances (PFAS)	10
Learning from experience: A retrospective analysis of read-across strategies for surfactants under REACH	10
Range of the perfluorooctanoate (PFOA) safe dose for human health: An international collaboration	10
SCCS scientific opinion on Butylated hydroxytoluene (BHT) - SCCS/1636/21	10
Development and application of a systematic and quantitative weighting framework to evaluate the quality and relevance of relative potency estimates for dioxin-like compounds (DLCs) for human health r	10
Historical control data of rare events: Issues, chronological patterns and their relevance for toxicological evaluations	10
Elucidation of 28 day repeated oral dose induced genotoxicity potential of nickel (II) oxide nanoparticles in wistar albino rats	10
Amphibian Metamorphosis Assay: Investigation of the potential effects of five chemicals on the hypothalamic-pituitary thyroid axis of Xenopus laevis	10
Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum	10
Selection of solvent and positive control concentration for enhanced Ames test conditions for N-nitrosamine compounds	10
A new approach methodology using kinetically-derived maximum dose levels in risk assessment – A case study with afidopyropen	10
Preclinical evaluation of abuse potential of the peripherally-restricted kappa opioid receptor agonist HSK21542	10
Application of a new approach method (NAM) for inhalation risk assessment	10
Nitrosamine acceptable intakes should consider variation in molecular weight: The implication of stoichiometric DNA damage	10
Pharmacokinetic models for first-in-human dose selection of immune-activating products in oncology	9
Serial blood collection in anaesthetised rats: Enhancing animal welfare without the need for jugular vein catheterisation	9
The utility of hERG channel inhibition data in the derivation of occupational exposure limits	9
Editorial Board	9
A sustainable and innovative method to determine parabens in body creams for exposure and risk assessment	9
Effects of as-if risk framing of hazards on risk perception and its rebuttal	9
Site-specific cancer risk following cobalt exposure via orthopedic implants or in occupational settings: A systematic review and meta-analysis	9
Gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4BD), and gamma-butyrolactone (GBL) intoxication: A state-of-the-art review	9
Use of NAMs in a weight of evidence approach to evaluate the safety via the inhalation route of acetylated vetiver oil, in spray products	9
Acute and chronic toxicity in Sprague–Dawley rats of orally-administered total lignans from Arctii Fructus, a potential therapeutic drug for diabetes	9
Development of COVID-19 therapies: Nonclinical testing considerations	9
Three-tiered approach for standard information requirements for polymers requiring registration under REACH	9
Physiologically based pharmacokinetic (PBPK) modeling of perfluorohexane sulfonate (PFHxS) in humans	9
Rebuttal to the letter to the editors regarding Van Berlo et al. (2022) paper titled “10% body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis”	9
Estimating uncertainty in LLNA EC3 data and its impact on regulatory classifications	9
Long-term e-cigarette aerosol exposure causes pulmonary emphysema in adult female and male mice	9
10% Body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis	8
A proposed NAM-based tiered phototoxicity testing and human risk assessment framework for agrochemicals	8
Challenges in the classification of chemical respiratory allergens based on human data: Case studies of 2-hydroxyethylmethacrylate (HEMA) and 2-hydroxypropylmethacrylate (HPMA)	8
Absence of phototoxicity/photoirritation potential of bergamottin determined In Vitro using OECD TG 432	8

GARD™skin and GARD™potency: A proof-of-concept study investigating applicability domain for agrochemical formulations	8
Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens	8
A double-blind, randomized, two-part, two-period crossover study to evaluate the pharmacokinetics of caffeine versus d9-caffeine in healthy subjects	8
A scoping review of infant and children health effects associated with cadmium exposure	8
Toxicology of bromoform, a natural constituent of the seaweed Asparagopsis spp. used to inhibit methanogenesis in cattle, suggests negligible risks to humans	8
Comparison of toxicological effects and exposure levels between triclosan and its structurally similar chemicals using in vitro tests for read-across case study	8
Evaluation of the safety of ethanolic extract from Piper amalago L. (Piperaceae) leaves in vivo: Subacute toxicity and genotoxicity studies	8
How to resolve inconclusive predictions from defined approaches for skin sensitisation in OECD Guideline No. 497	8
Health safety of parabens evaluated by selected in vitro methods	8
Comparison of controlled drugs and new psychoactive substances (NPS) regulations in East and Southeast Asia	8
Food for thought — Paving the way for a UK roadmap towards optimum consumer safety: Development, Endorsement and Regulatory acceptance of New Approach Methodologies (NAMs) in Chemical Risk Assessment	8
Use of alternative test methods in a tiered testing approach to address photoirritation potential of fragrance materials	8
Substantiating chemical groups for read-across using molecular response profiles	8
An extended Reference Chemical Potency List (RCPL) for characterising the performance of New Approach Methodologies (NAMs) in measuring the skin sensitisation potency of fragrance chemicals	8
Safety assessment of MPTA: An oral acute and 90-day sub-chronic toxicity study in Sprague-Dawley rats	8
Propylene oxide derived glycol ethers: A review of the alkyl glycol ethers potential to cause endocrine disruption	7
Response to letter to editor “letter to the editors regarding “the Conundrum of the PFOA human half-life, an international collaboration.”	7
Fluoride concentrations in drinking water and health risk assessment in the south of Algeria	7
An analysis of the use of historical control data in the assessment of regulatory pesticide toxicity studies	7
Comparison of carbonyls and tobacco-specific nitrosamines in aerosols of heated tobacco products and conventional cigarette smoke using both targeted and untargeted analytical methods	7
The discovery and preclinical pharmacology of JNJ-10450232 (NTM-006), a centrally penetrant, non-opioid structural analog of acetaminophen with comparable analgesic and anti-pyretic properties but no	7
Use of biomarker data and metabolite relative potencies to support derivation of noncancer reference values based on the reproductive and developmental toxicity effects of 1,3-butadiene	7
Expansion of the Cosmetics Europe skin sensitisation database with new substances and PPRA data	7
The new paradigm in animal testing – “3Rs alternatives”	7
Recommendation for an occupational exposure limit for toluene	7
Editorial Board	7
Evaluating high-throughput assays for pesticide ecological risk assessment	7
Exposure considerations in human safety assessment: Report from an EPAA Partners’ Forum	7
Biomonitoring Equivalents for N,N-Diethyl-meta-toluamide (DEET)	7
Quantitative risk assessment of allergens leaching from menstrual hygiene products	7
REACHing for solutions: Essential revisions to the EU chemicals regulation to modernise safety assessment	7
Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses	7
Best practices for exposure model peer review – A SciPinion advisory panel report	7
Statistical applications of virtual control groups to nonrodent animal toxicity studies: An initial evaluation	6
Model systems and organisms for addressing inter- and intra-species variability in risk assessment	6
Experiences and initiatives on pharmacokinetic modeling and simulation data analysis: Perspectives from the Brazilian Health Regulatory Agency (ANVISA)	6
Implications of variability on medical device chemical equivalence assessment	6
The role of trust in the use of artificial intelligence for chemical risk assessment	6
Tiered human health risk assessment of antibacterial quaternary ammonium compounds (QACs) in dishwashing detergents	6
A new paradigm for regulatory sciences	6
Derivation of subacute guidance values for chemical contaminants of drinking water quality standard in Japan	6
Systematic update to the mammalian relative potency estimate database and development of best estimate toxic equivalency factors for dioxin-like compounds	6
Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines	6
Adeno-associated virus (AAV)-based gene therapy products: What are toxicity studies in non-human primates showing us?	6
Editorial: Looking back and forward	6
Subchronic safety assessment of CIGB-500 in beagle dog after repeated daily dose administration over 28 days	6
Editorial Board	6
Towards harmonisation of testing of nanomaterials for EU regulatory requirements on chemical safety – A proposal for further actions	6
2000–2023 over two decades of ICH S7A: has the time come for a revamp?	6
Mode of action Criteria for selection of the critical effect and safe dose range for PFOA by the Alliance for risk assessment	6
Semiquantitative sensitization safety assessment of extractable and leachables associated with parenteral pharmaceutical products	6
Correct calculations of a “safe” daily dose of raw materials for homeopathic remedies. Re: Toxicological assessment compilation of selected examples of raw materials for homeopathic and anthroposophic	6
Reproductive and developmental toxicity risk assessment for 4-methylimidazole	6
Liver biomarkers in adults: Evaluation of associations with reported green tea consumption and use of green tea supplements in U.S. NHANES	6
Risk assessment of nutrients: There must be a threshold for their effects	6
In vivo alkaline comet assay: Statistical considerations on historical negative and positive control data	6
Radon concentration and physicochemical properties measurement and internal exposure assessment in different brands of commercial soft drinks consumed in Türkiye	6
A toxicological evaluation for safety assessment of ruthenium-based diosmetin complex in rats	6
Editorial Board	6
Analytical chemistry solutions to hazard evaluation of petroleum refining products	6
A tiered approach to investigate the inhalation toxicity of cobalt substances. Introduction: Cobalt's essential role in nature and technology	6
Is schedule IV suvorexant an appropriate reference drug of abuse to use in preclinical abuse liability testing in the rat?	6
Letter to the editor regarding “A systematic review of adverse health effects associated with oral cadmium exposure”	6
Safe- and sustainable-by-design: The case of Smart Nanomaterials. A perspective based on a European workshop	6
Letter to the editors regarding “The conundrum of the PFOA human half-life, an international collaboration”	5
Monosodium glutamate in a type 2 diabetes context: A large scoping review	5
Can “Hazard-Cost-Effectiveness Analysis” improve the risk management of chemicals under REACH?	5
A comprehensive review of sources of nitrosamine contamination of pharmaceutical substances and products	5
Considerations of non-human primate use in nonclinical toxicity study package for oncology therapeutics with well-characterized target in supports of 3Rs – an IQ DruSafe industry survey	5
Re-evaluation of the reduced heart weights in male rats in a 28-day oral repeated-dose toxicity study of tetramethylammonium hydroxide	5
Reproductive and developmental toxicity assessment of HSK21542, a novel peripherally-restricted kappa opioid receptor agonist in rats and rabbits	5
A comprehensive safety assessment of algae protein from Picochlorum for human consumption	5
Formation and evaluation of mechanism-based chemical categories for regulatory read-across assessment of repeated-dose toxicity: A case of hemolytic anemia	5
Regional regulatory harmonisation initiatives: Their potential contribution to the newly established African Medicines Agency	5
An Overview of Choice of Reference Biological Medicines in Current Turkish Biosimilar Guideline	5
Comparison of PAC and MOAH for understanding the carcinogenic and developmental toxicity potential of mineral oils	5
Platform-based opportunities to streamline animal use in support of the 3Rs – recommendations from an antibody-drug conjugate analysis	5
Safety assessment of phytase transgenic maize 11TPY050 in Sprague-Dawley rats by 90-day feeding study	5
Artificial intelligence and real-world data for drug and food safety – A regulatory science perspective	5
Application of physiologically-based pharmacokinetic modeled toluene blood concentration in the assessment of short term exposure limits	5
Editorial Board	5
A proposed approach to confirm heroin administration – Regional differences in heroin purity is a major factor	5
MODEXMO: A modular non-dietary exposure assessment approach for pesticides using dose-based dermal absorption prediction	5
Review of air concentrations of pesticides for estimating exposure to vapour in European risk assessments	5
SCCS scientific opinion on HAA299 (nano) - SCCS/1634/21	5
The need for guidance in antidepressant drug development: Revisiting the role of the forced swim test and tail suspension test	5
Response to the Letter to the Editor by David W Roberts “Dealing with substances with no defined molecular weight in non-animal assays for skin sensitization. A comment on “Plant extracts, polymers an	5
Biomonitoring and risk assessment of human exposure to triazole fungicides	5
Carcinogenic and neurotoxic risks of acrylamide consumed through bread, kaak, toast, and crackers among the Lebanese Population	5
Updated assessment of the genotoxic potential of titanium dioxide based on reviews of in vitro comet, mode of action and cellular uptake studies, and recent publications	5
A UK framework for the assessment and integration of different scientific evidence streams in chemical risk assessment	5
Ambient air concentrations of plant protection products: Data collection for the combined air concentration database and associated risk assessment	5
The Decision Tree approach as a strategy for the global phase out of animal testing for acute and local toxicity for chemicals: recommendations from an expert workshop	5
Applicability of nanomaterial-specific guidelines within long-term Daphnia magna toxicity assays: A case study on multigenerational effects of nTiO2 and nCeO2 exposure in the presence of artificial da	5
Challenges and opportunities of read-across for the tumor promotion effects of microcystins	5