Regulatory Toxicology and Pharmacology

Article	Citations
An evaluation framework for new approach methodologies (NAMs) for human health safety assessment	105
Regulatory landscape of dietary supplements and herbal medicines from a global perspective	104
Regulatory landscape of nanotechnology and nanoplastics from a global perspective	96
An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)	93
Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials	80
Are all nitrosamines concerning? A review of mutagenicity and carcinogenicity data	71
Regulations for calcium, magnesium or hardness in drinking water in the European Union member states	66
Pulmonary toxicity of silver vapours, nanoparticles and fine dusts: A review	58
Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply?	57
Toxicity of boric acid, borax and other boron containing compounds: A review	49
Review of regulatory reference values and background levels for heavy metals in the human diet	47
Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients	45
Progress towards an OECD reporting framework for transcriptomics and metabolomics in regulatory toxicology	44
Human health hazard assessment of quaternary ammonium compounds: Didecyl dimethyl ammonium chloride and alkyl (C12–C16) dimethyl benzyl ammonium chloride	44
Can we define a level of protection for allergic consumers that everyone can accept?	40
Nonclinical safety assessment of repeated administration and biodistribution of a novel rabies self-amplifying mRNA vaccine in rats	38
Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients	37
Final opinion on the safety of breast implants in relation to anaplastic large cell lymphoma: Report of the scientific committee on health, emerging and environmental risks (SCHEER)	37
“Natural” is not synonymous with “Safe”: Toxicity of natural products alone and in combination with pharmaceutical agents	37
Occupational exposure to hexavalent chromium. Part II. Hazard assessment of carcinogenic effects	36
New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop	33
PBPK model reporting template for chemical risk assessment applications	32
Toxicological evaluation of exosomes derived from human adipose tissue-derived mesenchymal stem/stromal cells	31
Silica dioxide nanoparticles aggravate airway inflammation in an asthmatic mouse model via NLRP3 inflammasome activation	30
A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment	30

Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds	29
Skin sensitization in silico protocol	29
Occupational exposure to hexavalent chromium. Part I. Hazard assessment of non-cancer health effects	29
Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture	29
Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop	28
Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations	26
Reflections on the OECD guidelines for in vitro skin absorption studies	26
The SCCS Notes of Guidance for the testing of cosmetic ingredients and their safety evaluation, 11th revision, 30–31 March 2021, SCCS/1628/21	25
Determining the impact of flavored e-liquids on aldehyde production during Vaping	24
Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential	24
Replacing the refinement for skin sensitization testing: Considerations to the implementation of adverse outcome pathway (AOP)-based defined approaches (DA) in OECD guidelines	24
A call for action on the development and implementation of new methodologies for safety assessment of chemical-based products in the EU – A short communication	23
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation	22
A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals	21
An evaluation of the genotoxicity and subchronic toxicity of the peel extract of Ponkan cultivar ‘Ohta ponkan’ (Citrus reticulata Blanco) that is rich in nobiletin and tangeretin with anti-dementia ac	21
Assessment of black cumin (Nigella sativa L.) as a food ingredient and putative therapeutic agent	21
Bolstering the existing database supporting the non-cancer Threshold of Toxicological Concern values with toxicity data on fragrance-related materials	21
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine	20
Safe- and sustainable-by-design: The case of Smart Nanomaterials. A perspective based on a European workshop	20
Short-term toxicogenomics as an alternative approach to chronic in vivo studies for derivation of points of departure: A case study in the rat with a triazole fungicide	20
Implementation of the principles of the 3Rs of animal testing at CDER: Past, present and future	19
Antimony release from polyester textiles by artificial sweat solutions: A call for a standardized procedure	19
Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice	19
A comprehensive review of mechanistic insights into formaldehyde-induced nasal cavity carcinogenicity	19
Read-across can increase confidence in the Next Generation Risk Assessment for skin sensitisation: A case study with resorcinol	19
Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens	18
Regulating human safety: How dose selection in toxicity studies impacts human health hazard assessment and subsequent risk management options	18
Analysis of variability in the rabbit skin irritation assay	18
Use of the kinetically-derived maximum dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management	18
Assessment of the potential allergenicity and toxicity of Pichia proteins in a novel leghemoglobin preparation	18
Role of Diosmin in protection against the oxidative stress induced damage by gamma-radiation in Wistar albino rats	18
Characterization of tea tree oil nanoemulsion and its acute and subchronic toxicity	17
Evaluation of the toxicity of sodium dodecyl sulphate (SDS) in the MucilAir™ human airway model in vitro	17
Human Biomonitoring (HBM)-I values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) - Description, derivation and discussion	17
Utilisation of parametric methods to improve percentile-based estimates for the carcinogenic potency of nitrosamines	17
R-ODAF: Omics data analysis framework for regulatory application	16
A weight of evidence review of the genotoxicity of titanium dioxide (TiO2)	16
Human biomonitoring (HBM)-II values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) - Description, derivation and discussion	16
Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines	16
Risk assessment of unintentional phthalates contaminants in cosmetics	16
Comparative nonclinical assessments of the biosimilar PF-06410293 and originator adalimumab	16
Determination of inorganic arsenic, heavy metals, pesticides and mycotoxins in Indian rice (Oryza sativa) and a probabilistic dietary risk assessment for the population of Saudi Arabia	16
Considerations for determining safety of probiotics: A USP perspective	16
Safety assessment of astaxanthin from Haematococcus pluvialis: Acute toxicity, genotoxicity, distribution and repeat-dose toxicity studies in gestation mice	16
Development of improved QSAR models for predicting the outcome of the in vivo micronucleus genetic toxicity assay	15
Compounded conservatism in European re-entry worker risk assessment of pesticides	15
Carcinogenic hazard assessment of cobalt-containing alloys in medical devices: Review of in vivo studies	15
10% Body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis	15
Incorporating lines of evidence from New Approach Methodologies (NAMs) to reduce uncertainties in a category based read-across: A case study for repeated dose toxicity	15
The performance, reliability and potential application of in silico models for predicting the acute oral toxicity of pharmaceutical compounds	15

Management of pharmaceutical ICH M7 (Q)SAR predictions – The impact of model updates	15
Advances in selecting appropriate non-rodent species for regulatory toxicology research: Policy, ethical, and experimental considerations	14
Use of less-than-lifetime (LTL) durational limits for nitrosamines: Case study of N-Nitrosodiethylamine (NDEA)	14
Application of a new approach method (NAM) for inhalation risk assessment	14
Application of structural and functional pharmacokinetic analogs for physiologically based pharmacokinetic model development and evaluation	14
Towards harmonisation of testing of nanomaterials for EU regulatory requirements on chemical safety – A proposal for further actions	14
Safety evaluation of Eucommia ulmoides extract	14
Using historical control data in bioassays for regulatory toxicology	14
Evaluation of the carcinogenicity of dichloromethane in rats, mice, hamsters and humans	14
Evaluation of the applicability of existing (Q)SAR models for predicting the genotoxicity of pesticides and similarity analysis related with genotoxicity of pesticides for facilitating of grouping and	14
Adeno-associated virus (AAV)-based gene therapy products: What are toxicity studies in non-human primates showing us?	14
Towards the development of an omics data analysis framework	14
Next generation risk assessment for skin allergy: Decision making using new approach methodologies	14
Acute and sub-chronic toxicity studies of Benincasa hispida (Thunb.) cogniaux fruit extract in rodents	14
A matched molecular pair (MMP) approach for selecting analogs suitable for structure activity relationship (SAR)-based read across	13
A systematic review of adverse health effects associated with oral cadmium exposure	13
Application of the dermal sensitization threshold concept to chemicals classified as high potency category for skin sensitization assessment of ingredients for consumer products	13
Establishing health-based biological exposure limits for pesticides: A proof of principle study using mancozeb	13
Updated interim reference levels for dietary lead to support FDA's Closer to Zero action plan	13
Effect of low- and high-level groundwater arsenic on peripheral blood and lung function of exposed rural women	13
Recommendations for further revisions to improve the International Agency for Research on Cancer (IARC) Monograph program	13
Automated read-across workflow for predicting acute oral toxicity: I. The decision scheme in the QSAR toolbox	13
Acute and repeated dose 28-day oral toxicity of Chrysobalanus icaco L. leaf aqueous extract	13
The Botanical Safety Consortium: A public-private partnership to enhance the botanical safety toolkit	12
Selecting a minimal set of androgen receptor assays for screening chemicals	12
Assessment of veterinary drug residues in food: Considerations when dealing with sub-optimal data	12
A scoping review of infant and children health effects associated with cadmium exposure	12
Time extrapolation in regulatory risk assessment: The impact of study differences on the extrapolation factors	12
Review of the pharmacokinetics and metabolism of triclopyr herbicide in mammals: Impact on safety assessments	12
Integration of toxicodynamic and toxicokinetic new approach methods into a weight-of-evidence analysis for pesticide developmental neurotoxicity assessment: A case-study with DL- and L-glufosinate	12
A cross-industry collaboration to assess if acute oral toxicity (Q)SAR models are fit-for-purpose for GHS classification and labelling	12
Development of peptide therapeutics: A nonclinical safety assessment perspective	12
Comparisons of PNEC derivation logic flows under example regulatory schemes and implications for ecoTTC	12
An interim internal Threshold of Toxicologic Concern (iTTC) for chemicals in consumer products, with support from an automated assessment of ToxCast™ dose response data	12
Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen	12
Metabolic fate in adult and pediatric population of steviol glycosides produced from stevia leaf extract by different production technologies	12
Considerations for setting occupational exposure limits for novel pharmaceutical modalities	12
Aloe-emodin, a hydroxyanthracene derivative, is not genotoxic in an in vivo comet test	12
Rethinking chronic toxicity and carcinogenicity assessment for agrochemicals project (ReCAAP): A reporting framework to support a weight of evidence safety assessment without long-term rodent bioassay	12
Comparison of PAC and MOAH for understanding the carcinogenic and developmental toxicity potential of mineral oils	12
Use compatibility intervals in regulatory toxicology	11
A comprehensive review of sources of nitrosamine contamination of pharmaceutical substances and products	11
Mercury in skin-care products in India and consumer exposure risks	11
Dose-response assessment for impaired memory from chronic exposure to domoic acid among native American consumers of razor clams	11
Grouping of PFAS for human health risk assessment: Findings from an independent panel of experts	11
Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment	11
“New statistics” in regulatory toxicology?	11
The Dilemma of perfluorooctanoate (PFOA) human half-life	11
A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 3: Inflammatory response following acute inhalation exposure correlates with lower tier data	11
A review to support the derivation of a worst-case dermal penetration value for nanoparticles	11
Model systems and organisms for addressing inter- and intra-species variability in risk assessment	11
How the 62-year old Delaney Clause continues to thwart science: Case study of the flavor substance β-myrcene	11
Non-dioxin-like polychlorinated biphenyl neurotoxic equivalents found in environmental and human samples	11
A hypothetical skin sensitisation next generation risk assessment for coumarin in cosmetic products	11
Assessing the impact of expert knowledge on ICH M7 (Q)SAR predictions. Is expert review still needed?	11
The Conundrum of the PFOA human half-life, an international collaboration	10
Safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients	10
Chronic oral toxicity of 3-nitro-1,2,4-triazol-5-one (NTO) in rats	10
A hazard evaluation of the reproductive/developmental toxicity of cobalt in medical devices	10
Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning CatBoost	10
Effect of chain length and branching on the in vitro metabolism of a series of parabens in human liver S9, human skin S9, and human plasma	10
Determination of “fitness-for-purpose” of quantitative structure-activity relationship (QSAR) models to predict (eco-)toxicological endpoints for regulatory use	10
In vitro skin penetration of bronidox, bronopol and formaldehyde from cosmetics	9
Evaluating chemical similarity as a measure to identify potential substances of very high concern	9
Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study	9
Comparison of threshold of toxicological concern (TTC) values to oral reference dose (RfD) values	9
Lay people and experts’ risk perception of pharmaceuticals in the environment in Southwestern Europe	9
Non-sugar sweeteners and cancer: Toxicological and epidemiological evidence	9
A tiered approach to investigate the inhalation toxicity of cobalt substances. Introduction: Cobalt's essential role in nature and technology	9
In vivo safety testing of Antibody Drug Conjugates	9
FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations	9
Carcinogenic assessment of cobalt-containing alloys in medical devices or cobalt in occupational settings: A systematic review and meta-analysis of overall cancer risk from published epidemiologic stu	9
In silico assessment of genotoxicity. Combinations of sensitive structural alerts minimize false negative predictions for all genotoxicity endpoints and can single out chemicals for which experimentat	9
Determination of the stereoisomeric distribution of R-(−)- and S-(+)-methamphetamine in Thai pills in the legal context of “not inconsiderable quantities"	9
Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs)	9
The SCCS guidance on the safety assessment of nanomaterials in cosmetics	9
Support vector machine-based model for toxicity of organic compounds against fish	9
A weight of evidence assessment of the genotoxicity of 2,6-xylidine based on existing and new data, with relevance to safety of lidocaine exposure	9
Aloe gel-base food products: Chemical, toxicological, and regulatory aspects	9
Gaps and challenges in nonclinical assessments of pharmaceuticals: An FDA/CDER perspective on considerations for development of new approach methodologies	9

Classification of chemicals as respiratory allergens based on human data: Requirements and practical considerations	9
Evaluation of the sub-acute toxicity of Acacia catechu Willd seed extract in a Wistar albino rat model	8
Systematic review of the potential carcinogenicity of bisphenol A in humans	8
Computational identification of preservatives with potential neuronal cytotoxicity	8
Conformity assessment of medicines containing antibiotics – A multivariate assessment	8
Next generation risk assessment for skin sensitisation: A case study with propyl paraben	8
Evaluation of the predictivity of Acute Oral Toxicity (AOT) structure-activity relationship models	8
Opinion of the Scientific Committee on Consumer Safety (SCCS) – Final Opinion on propylparaben (CAS No 94-13-3, EC No 202-307-7)	8
Toxicological risk assessment of bisphenol a released from dialyzers under simulated-use and exaggerated extraction conditions	8
Updating the Dermal Sensitisation Thresholds using an expanded dataset and an in silico expert system	8
Genotoxicity evaluation of a valsartan-related complex N-nitroso-impurity	8
A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 2a: Grouping cobalt compounds based on their capacity to stabilize HIF-1α in human alveolar epithelial cells in vitr	8
Rethinking agrochemical safety assessment: A perspective	8
Organic compounds percutaneous penetration in vivo in man: Relationship to mathematical predictive model	8
An analysis of the setting of the acute reference dose (ARfD) for pesticides in Europe	8
A novel approach to monitor skin permeation of metals in vitro	8
Metribuzin-induced non-adverse liver changes result in rodent-specific non-adverse thyroid effects via uridine 5′-diphospho-glucuronosyltransferase (UDPGT, UGT) modulation	8
Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity	8
Exposure to environmentally-relevant concentrations of hexavalent chromium does not induce ovarian toxicity in mice	8
Occupational exposure to Cr(VI) in Finland in 1980–2016 and related lung cancer risk assessment	8
Analysis and reflection on the role of the 90-day oral toxicity study in European chemical risk assessment	8
Expansion of the Cosmetics Europe skin sensitisation database with new substances and PPRA data	8
Safety evaluation of water extract of Gastrodia elata Blume: Genotoxicity and 28-day oral toxicity studies	8
In vitro and in vivo evaluation of probiotic potential and safety assessment of Bacillus coagulans SKB LAB-19 (MCC 0554) in humans and animal healthcare	8
Association of dietary intake and urinary excretion of inorganic arsenic in the Japanese subjects	8
Risk assessment of predicted serum concentrations of bisphenol A in children and adults following treatment with dental composite restoratives, dental sealants, or orthodontic adhesives using physiolo	8
The purity of tattoo inks, screening substances of high concern	7
Safety evaluation of food enzymes produced by a safe strain lineage of Bacillus subtilis	7
Site-specific cancer risk following cobalt exposure via orthopedic implants or in occupational settings: A systematic review and meta-analysis	7
Evaluation of the OECD QSAR toolbox automatic workflow for the prediction of the acute toxicity of organic chemicals to fathead minnow	7
Beyond dermal exposure: The respiratory tract as a target organ in hazard assessments of cosmetic ingredients	7
Toxicological evaluation of, red rice yeast extract, Xuezhikang: Acute, 26-week chronic and genotoxicity studies	7
Toxicological assessment method for evaluating the occupational risk of dynamic olfactometry assessors	7
DP-2Ø2216-6 maize does not adversely affect rats in a 90-day feeding study	7
The safety of a Kluyveromyces lactis strain lineage for enzyme production	7
Initial hazard assessment of 1,4-dichlorobutane: Genotoxicity tests, 28-day repeated-dose toxicity test, and reproductive/developmental toxicity screening test in rats	7
Considerations when deriving compound-specific limits for extractables and leachables from pharmaceutical products: Four case studies	7
Comparison of the potential mechanisms for hepatotoxicity of p-dialkoxy chlorobenzenes in rat primary hepatocytes for read-across	7
Preclinical screening for antidepressant activity – shifting focus away from the Forced Swim Test to the use of translational biomarkers	7
Facilitation of risk assessment with evidence-based methods – A framework for use of systematic mapping and systematic reviews in determining hazard, developing toxicity values, and characterizing unc	7
Ni and Cr impurities profile in Valeriana officinalis L., radix-based herbal medicinal product available in polish pharmacies due to ICH Q3D guideline	7
Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits	7
Confidence interval function analysis to evaluate the risk of mesothelioma among an expanded international cohort of cosmetic talc miners and millers	7
Nonclinical & clinical interface - extrapolation of nonclinical data to support Phase I clinical studies	7
Standardization, in-silico and in-vivo safety assessment of methanol extract of Ziziphus mauritiana Lam leaves	7
Expanding the toxicologist's statistical toolbox: Using effect size estimation and dose-response modelling for holistic assessments instead of generic testing	7
A flow scheme for cumulative assessment of pesticides for adverse liver effects	7
Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes	7
A scheme to evaluate structural alerts to predict toxicity – Assessing confidence by characterising uncertainties	7
Making in silico predictive models for toxicology FAIR	7
Heavy metal contamination in recorded and unrecorded spirits. Should we worry?	7
The Threshold of Toxicological Concern (TTC) is a pragmatic tool for the safety assessment: Case studies of cosmetic ingredients with low consumer exposure	7
A toxicological evaluation of geranylgeraniol	7
Draize human repeat insult patch test (HRIPT): Seven decades of pitfalls and progress	6
Safety assessment of MPTA: An oral acute and 90-day sub-chronic toxicity study in Sprague-Dawley rats	6
Inhalation toxicity of cyclic semi-volatile methylsiloxanes: Disentangling the conundrum of phase-specific adaptations from adverse outcomes	6
Evaluation of the safety of ethanolic extract from Piper amalago L. (Piperaceae) leaves in vivo: Subacute toxicity and genotoxicity studies	6
Retrospective analysis of the potential use of virtual control groups in preclinical toxicity assessment using the eTOX database	6
Letter to the editor regarding Heringa et al. (2020) paper entitled “Use of the Kinetically-derived Maximum Dose concept in selection of top doses for toxicity studies hampers proper hazard assessment	6
Effects of an ethanolic extract and fractions from Piper glabratum (Piperaceae) leaves on pain and inflammation	6
Safety of medicinal comfrey cream preparations (Symphytum officinale s.l.): The pyrrolizidine alkaloid lycopsamine is poorly absorbed through human skin	6
A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 2 b: Reactive cobalt substances induce oxidative stress in ToxTracker and activate hypoxia target genes	6
The activity of methacrylate esters in skin sensitisation test methods II. A review of complementary and additional analyses	6
Use of alternative test methods in a tiered testing approach to address photoirritation potential of fragrance materials	6
Development of COVID-19 therapies: Nonclinical testing considerations	6
RespiraTox – Development of a QSAR model to predict human respiratory irritants	6
Indicators for lack of systemic availability of organic pigments	6
A TRPV1 antagonist, PAC-14028 does not increase the risk of tumorigenesis in chemically induced mouse skin carcinogenesis	6
Artificial intelligence and real-world data for drug and food safety – A regulatory science perspective	6
Evidence-based regulations for bioinformatic prediction of allergen cross-reactivity are needed	6
Unexpected neurotoxicity in chronic toxicity studies with a HBV viral expression inhibitor	6
Performance of the GHS Mixtures Equation for Predicting Acute Oral Toxicity	6
Fluoride concentrations in drinking water and health risk assessment in the south of Algeria	6
The genotoxicity of an organic solvent mixture: A human biomonitoring study and translation of a real-scenario exposure to in vitro	6
Yellow-colored extract from cashew byproduct – Nonclinical safety assessment	6
A comprehensive weight of evidence assessment of published acetaminophen genotoxicity data: Implications for its carcinogenic hazard potential	6
How to resolve inconclusive predictions from defined approaches for skin sensitisation in OECD Guideline No. 497	6
Human exposure to toxic elements through facial cosmetic products: Dermal risk assessment	6
Classes of organic pigments meet tentative PSLT criteria and lack toxicity in short-term inhalation studies	6
Sub-structure-based category formation for the prioritisation of genotoxicity hazard assessment for pesticide residues: Sulphonyl ureas	6
Dietary pectin at 0.2% in milk replacer did not inhibit growth, feed intake, or nutrient digestibility in a 3-week neonatal pig study	6
Acute and subacute oral toxicity of artemisinin-hydroxychloroquine sulfate tablets in rats	6
Benchmarking performance of SENS-IS assay against weight of evidence skin sensitization potency categories	6
A 90-day drinking water study in mice to characterize early events in the cancer mode of action of 1,4-dioxane	6
Clinical epidemiology studies on potential effects of endocrine disrupting chemicals (EDCs) should exclude subjects with obesity as determined by BMI	6
Iraqi regulatory authority current system and experience with biosimilars	5
Extended One-Generation Reproductive Toxicity (EOGRT) study of benzoic acid in Sprague Dawley rats	5
Evaluation of chronic toxicity of cyclocreatine, a creatine analog, in Sprague Dawley rat after oral gavage administration for up to 26 weeks	5
Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum	5
Decision making in next generation risk assessment for skin allergy: Using historical clinical experience to benchmark risk	5
Use of toxicokinetic data for afidopyropen to determine the dose levels in developmental toxicity studies	5
A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential	5
Genotoxicity and subchronic toxicity studies of supercritical carbon dioxide and acetone extracts of rosemary	5
Ethylene oxide derived glycol ethers: A review of the alkyl glycol ethers potential to cause endocrine disruption	5
Toxicological evaluation of a glycan preparation from an enzymatic hydrolysis of Saccharomyces cerevisiae	5