Regulatory Toxicology and Pharmacology

Article	Citations
Regulatory landscape of nanotechnology and nanoplastics from a global perspective	133
Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials	87
Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply?	67
Toxicity of boric acid, borax and other boron containing compounds: A review	65
Review of regulatory reference values and background levels for heavy metals in the human diet	59
Progress towards an OECD reporting framework for transcriptomics and metabolomics in regulatory toxicology	55
Can we define a level of protection for allergic consumers that everyone can accept?	47
Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients	44
Occupational exposure to hexavalent chromium. Part I. Hazard assessment of non-cancer health effects	44
Occupational exposure to hexavalent chromium. Part II. Hazard assessment of carcinogenic effects	43
Final opinion on the safety of breast implants in relation to anaplastic large cell lymphoma: Report of the scientific committee on health, emerging and environmental risks (SCHEER)	41
Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop	41
A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment	40
Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations	34
Safe- and sustainable-by-design: The case of Smart Nanomaterials. A perspective based on a European workshop	33
Reflections on the OECD guidelines for in vitro skin absorption studies	32
The SCCS Notes of Guidance for the testing of cosmetic ingredients and their safety evaluation, 11th revision, 30–31 March 2021, SCCS/1628/21	30
Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice	28
Corrigendum to “Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products” [Regul. Toxicol. Pharmacol. 72 3 (2015) 673-68]	27
Towards harmonisation of testing of nanomaterials for EU regulatory requirements on chemical safety – A proposal for further actions	26
Assessment of black cumin (Nigella sativa L.) as a food ingredient and putative therapeutic agent	26
Analysis of variability in the rabbit skin irritation assay	25
Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential	25
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine	25
A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals	25

Assessment of the potential allergenicity and toxicity of Pichia proteins in a novel leghemoglobin preparation	24
Considerations for determining safety of probiotics: A USP perspective	24
A call for action on the development and implementation of new methodologies for safety assessment of chemical-based products in the EU – A short communication	24
Evaluation of the toxicity of sodium dodecyl sulphate (SDS) in the MucilAir™ human airway model in vitro	23
A weight of evidence review of the genotoxicity of titanium dioxide (TiO2)	23
A comprehensive review of mechanistic insights into formaldehyde-induced nasal cavity carcinogenicity	22
Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens	22
R-ODAF: Omics data analysis framework for regulatory application	22
Implementation of the principles of the 3Rs of animal testing at CDER: Past, present and future	22
Next generation risk assessment for skin allergy: Decision making using new approach methodologies	21
Updated interim reference levels for dietary lead to support FDA's Closer to Zero action plan	21
Rethinking chronic toxicity and carcinogenicity assessment for agrochemicals project (ReCAAP): A reporting framework to support a weight of evidence safety assessment without long-term rodent bioassay	21
Read-across can increase confidence in the Next Generation Risk Assessment for skin sensitisation: A case study with resorcinol	21
Human Biomonitoring (HBM)-I values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) - Description, derivation and discussion	21
A comprehensive review of sources of nitrosamine contamination of pharmaceutical substances and products	21
Model systems and organisms for addressing inter- and intra-species variability in risk assessment	20
10% Body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis	20
Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines	20
Acute and sub-chronic toxicity studies of Benincasa hispida (Thunb.) cogniaux fruit extract in rodents	20
Antimony release from polyester textiles by artificial sweat solutions: A call for a standardized procedure	20
Application of a new approach method (NAM) for inhalation risk assessment	19
A systematic review of adverse health effects associated with oral cadmium exposure	19
Management of pharmaceutical ICH M7 (Q)SAR predictions – The impact of model updates	19
Characterization of tea tree oil nanoemulsion and its acute and subchronic toxicity	19
Incorporating lines of evidence from New Approach Methodologies (NAMs) to reduce uncertainties in a category based read-across: A case study for repeated dose toxicity	18
The Botanical Safety Consortium: A public-private partnership to enhance the botanical safety toolkit	18
The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls	18
Compounded conservatism in European re-entry worker risk assessment of pesticides	18
A scoping review of infant and children health effects associated with cadmium exposure	18
Non-sugar sweeteners and cancer: Toxicological and epidemiological evidence	18
Carcinogenic hazard assessment of cobalt-containing alloys in medical devices: Review of in vivo studies	18
Human biomonitoring (HBM)-II values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) - Description, derivation and discussion	18
Utilisation of parametric methods to improve percentile-based estimates for the carcinogenic potency of nitrosamines	17
FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations	17
Determination of inorganic arsenic, heavy metals, pesticides and mycotoxins in Indian rice (Oryza sativa) and a probabilistic dietary risk assessment for the population of Saudi Arabia	17
Considerations for setting occupational exposure limits for novel pharmaceutical modalities	17
A review to support the derivation of a worst-case dermal penetration value for nanoparticles	17
The performance, reliability and potential application of in silico models for predicting the acute oral toxicity of pharmaceutical compounds	16
Aloe-emodin, a hydroxyanthracene derivative, is not genotoxic in an in vivo comet test	16
Using historical control data in bioassays for regulatory toxicology	16
Evaluation of the carcinogenicity of dichloromethane in rats, mice, hamsters and humans	16
Grouping of PFAS for human health risk assessment: Findings from an independent panel of experts	16
Adeno-associated virus (AAV)-based gene therapy products: What are toxicity studies in non-human primates showing us?	16
Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs)	16
Integration of toxicodynamic and toxicokinetic new approach methods into a weight-of-evidence analysis for pesticide developmental neurotoxicity assessment: A case-study with DL- and L-glufosinate	15
A cross-industry collaboration to assess if acute oral toxicity (Q)SAR models are fit-for-purpose for GHS classification and labelling	15
Use of less-than-lifetime (LTL) durational limits for nitrosamines: Case study of N-Nitrosodiethylamine (NDEA)	15
Comparisons of PNEC derivation logic flows under example regulatory schemes and implications for ecoTTC	15
Selecting a minimal set of androgen receptor assays for screening chemicals	15
Assessment of veterinary drug residues in food: Considerations when dealing with sub-optimal data	14

Gaps and challenges in nonclinical assessments of pharmaceuticals: An FDA/CDER perspective on considerations for development of new approach methodologies	14
A matched molecular pair (MMP) approach for selecting analogs suitable for structure activity relationship (SAR)-based read across	14
Comparison of PAC and MOAH for understanding the carcinogenic and developmental toxicity potential of mineral oils	14
Safety evaluation of Eucommia ulmoides extract	14
Automated read-across workflow for predicting acute oral toxicity: I. The decision scheme in the QSAR toolbox	14
A hypothetical skin sensitisation next generation risk assessment for coumarin in cosmetic products	14
The Dilemma of perfluorooctanoate (PFOA) human half-life	13
Application of the dermal sensitization threshold concept to chemicals classified as high potency category for skin sensitization assessment of ingredients for consumer products	13
Dose-response assessment for impaired memory from chronic exposure to domoic acid among native American consumers of razor clams	13
Assessing the impact of expert knowledge on ICH M7 (Q)SAR predictions. Is expert review still needed?	13
Development of peptide therapeutics: A nonclinical safety assessment perspective	13
Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment	13
Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen	12
Expansion of the Cosmetics Europe skin sensitisation database with new substances and PPRA data	12
Aloe gel-base food products: Chemical, toxicological, and regulatory aspects	12
Classification of chemicals as respiratory allergens based on human data: Requirements and practical considerations	12
Mercury in skin-care products in India and consumer exposure risks	12
Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach	12
Evaluating chemical similarity as a measure to identify potential substances of very high concern	12
Artificial intelligence and real-world data for drug and food safety – A regulatory science perspective	12
Lay people and experts’ risk perception of pharmaceuticals in the environment in Southwestern Europe	12
Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods	12
Occupational exposure to Cr(VI) in Finland in 1980–2016 and related lung cancer risk assessment	12
In vitro and in vivo evaluation of probiotic potential and safety assessment of Bacillus coagulans SKB LAB-19 (MCC 0554) in humans and animal healthcare	12
Non-dioxin-like polychlorinated biphenyl neurotoxic equivalents found in environmental and human samples	12
Evaluation of the predictivity of Acute Oral Toxicity (AOT) structure-activity relationship models	11
Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning CatBoost	11
Randomized, triple-blind, placebo-controlled study to evaluate the safety of 6′-Sialyllactose in healthy adults	11
Effect of chain length and branching on the in vitro metabolism of a series of parabens in human liver S9, human skin S9, and human plasma	11
Updating the Dermal Sensitisation Thresholds using an expanded dataset and an in silico expert system	11
Preclinical screening for antidepressant activity – shifting focus away from the Forced Swim Test to the use of translational biomarkers	11
Next generation risk assessment for skin sensitisation: A case study with propyl paraben	11
Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays	11
Human exposure to toxic elements through facial cosmetic products: Dermal risk assessment	11
The Conundrum of the PFOA human half-life, an international collaboration	11
A hazard evaluation of the reproductive/developmental toxicity of cobalt in medical devices	11
Genotoxicity evaluation of a valsartan-related complex N-nitroso-impurity	11
In vivo safety testing of Antibody Drug Conjugates	11
Support vector machine-based model for toxicity of organic compounds against fish	11
“New statistics” in regulatory toxicology?	11
Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study	11
A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 3: Inflammatory response following acute inhalation exposure correlates with lower tier data	11
Rethinking agrochemical safety assessment: A perspective	10
2000–2023 over two decades of ICH S7A: has the time come for a revamp?	10
Fluoride concentrations in drinking water and health risk assessment in the south of Algeria	10
Use of alternative test methods in a tiered testing approach to address photoirritation potential of fragrance materials	10
In silico assessment of genotoxicity. Combinations of sensitive structural alerts minimize false negative predictions for all genotoxicity endpoints and can single out chemicals for which experimentat	10
A tiered approach to investigate the inhalation toxicity of cobalt substances. Introduction: Cobalt's essential role in nature and technology	10
Computational identification of preservatives with potential neuronal cytotoxicity	10
Facilitation of risk assessment with evidence-based methods – A framework for use of systematic mapping and systematic reviews in determining hazard, developing toxicity values, and characterizing unc	10
In vitro skin penetration of bronidox, bronopol and formaldehyde from cosmetics	10
Me-too validation study for in vitro skin irritation test with a reconstructed human epidermis model, KeraSkin™ for OECD test guideline 439	10
Determination of “fitness-for-purpose” of quantitative structure-activity relationship (QSAR) models to predict (eco-)toxicological endpoints for regulatory use	10
Performance of the GHS Mixtures Equation for Predicting Acute Oral Toxicity	10
Making in silico predictive models for toxicology FAIR	10
Analysis and reflection on the role of the 90-day oral toxicity study in European chemical risk assessment	10
Toxicological assessment method for evaluating the occupational risk of dynamic olfactometry assessors	10
Safety evaluation of food enzymes produced by a safe strain lineage of Bacillus subtilis	10
Beyond dermal exposure: The respiratory tract as a target organ in hazard assessments of cosmetic ingredients	9
The Threshold of Toxicological Concern (TTC) is a pragmatic tool for the safety assessment: Case studies of cosmetic ingredients with low consumer exposure	9
Toxicological risk assessment of bisphenol a released from dialyzers under simulated-use and exaggerated extraction conditions	9
Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes	9
Systematic review of the potential carcinogenicity of bisphenol A in humans	9
Opinion of the Scientific Committee on Consumer Safety (SCCS) – Final Opinion on propylparaben (CAS No 94-13-3, EC No 202-307-7)	9
A weight of evidence assessment of the genotoxicity of 2,6-xylidine based on existing and new data, with relevance to safety of lidocaine exposure	9
Evaluation of the OECD QSAR toolbox automatic workflow for the prediction of the acute toxicity of organic chemicals to fathead minnow	9
Safety of medicinal comfrey cream preparations (Symphytum officinale s.l.): The pyrrolizidine alkaloid lycopsamine is poorly absorbed through human skin	9
A scheme to evaluate structural alerts to predict toxicity – Assessing confidence by characterising uncertainties	9
Carcinogenic assessment of cobalt-containing alloys in medical devices or cobalt in occupational settings: A systematic review and meta-analysis of overall cancer risk from published epidemiologic stu	9
Gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4BD), and gamma-butyrolactone (GBL) intoxication: A state-of-the-art review	9
Mutagenic impurities in pharmaceuticals: A critical assessment of the cohort of concern with a focus on N-nitrosamines	9
Calculating qualified non-mutagenic impurity levels: Harmonization of approaches	8
DP-2Ø2216-6 maize does not adversely affect rats in a 90-day feeding study	8
The safety of a Kluyveromyces lactis strain lineage for enzyme production	8
Considerations when deriving compound-specific limits for extractables and leachables from pharmaceutical products: Four case studies	8
Decision making in next generation risk assessment for skin allergy: Using historical clinical experience to benchmark risk	8
Site-specific cancer risk following cobalt exposure via orthopedic implants or in occupational settings: A systematic review and meta-analysis	8
A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 2a: Grouping cobalt compounds based on their capacity to stabilize HIF-1α in human alveolar epithelial cells in vitr	8
Conformity assessment of medicines containing antibiotics – A multivariate assessment	8
The purity of tattoo inks, screening substances of high concern	8

Expanding the toxicologist's statistical toolbox: Using effect size estimation and dose-response modelling for holistic assessments instead of generic testing	8
RespiraTox – Development of a QSAR model to predict human respiratory irritants	8
Subchronic oral toxicity study of rhubarb extract in Sprague-Dawley rats	8
Experimental study for the establishment of a chemotherapy-induced ovarian insufficiency model in rats by using cyclophosphamide combined with busulfan	8
Report on investigation of ISO 10993–12 extraction conditions	8
Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil	8
Harmonized 3Rs-based non-mutagenic impurity qualification study designs developed using the results of an IQ consortium survey	8
Plant extracts, polymers and new approach methods: Practical experience with skin sensitization assessment	8
Metribuzin-induced non-adverse liver changes result in rodent-specific non-adverse thyroid effects via uridine 5′-diphospho-glucuronosyltransferase (UDPGT, UGT) modulation	8
Risk assessment of predicted serum concentrations of bisphenol A in children and adults following treatment with dental composite restoratives, dental sealants, or orthodontic adhesives using physiolo	8
Unexpected neurotoxicity in chronic toxicity studies with a HBV viral expression inhibitor	7
A new paradigm for regulatory sciences	7
Current ecotoxicity testing needs among selected U.S. federal agencies	7
A double-blind, randomized, two-part, two-period crossover study to evaluate the pharmacokinetics of caffeine versus d9-caffeine in healthy subjects	7
Use of in vitro metabolism and biokinetics assays to refine predicted in vivo and in vitro internal exposure to the cosmetic ingredient, phenoxyethanol, for use in risk assessment	7
How to resolve inconclusive predictions from defined approaches for skin sensitisation in OECD Guideline No. 497	7
Development of COVID-19 therapies: Nonclinical testing considerations	7
Classes of organic pigments meet tentative PSLT criteria and lack toxicity in short-term inhalation studies	7
Ni and Cr impurities profile in Valeriana officinalis L., radix-based herbal medicinal product available in polish pharmacies due to ICH Q3D guideline	7
Effects of an ethanolic extract and fractions from Piper glabratum (Piperaceae) leaves on pain and inflammation	7
Benchmarking performance of SENS-IS assay against weight of evidence skin sensitization potency categories	7
A toxicological evaluation of geranylgeraniol	7
Inhalation cancer risk assessment for environmental exposure to hexavalent chromium: Comparison of margin-of-exposure and linear extrapolation approaches	7
Developing a database of systematic reviews of animal studies	7
Standardization, in-silico and in-vivo safety assessment of methanol extract of Ziziphus mauritiana Lam leaves	7
Nonclinical safety assessment of engineered T cell therapies	7
The contribution of larval zebrafish transcriptomics to chemical risk assessment	7
Acute and subacute oral toxicity of artemisinin-hydroxychloroquine sulfate tablets in rats	7
Considerations regarding the use of nonhuman primates in assessing safety endpoints for pharmaceuticals	7
Recommendation for an occupational exposure limit for toluene	7
A 90-day drinking water study in mice to characterize early events in the cancer mode of action of 1,4-dioxane	7
Nonclinical & clinical interface - extrapolation of nonclinical data to support Phase I clinical studies	7
Reassessment of the cadmium toxicological reference value for use in human health assessments of foods	7
Health safety of parabens evaluated by selected in vitro methods	7
A comprehensive weight of evidence assessment of published acetaminophen genotoxicity data: Implications for its carcinogenic hazard potential	7
Sub-structure-based category formation for the prioritisation of genotoxicity hazard assessment for pesticide residues: Sulphonyl ureas	7
A Cautionary tale for using read-across for cancer hazard classification: Case study of isoeugenol and methyl eugenol	7
Analytical chemistry solutions to hazard evaluation of petroleum refining products	6
Reproductive and developmental toxicity screening of bisphenol F by oral gavage in rats	6
Improving the regulatory environmental risk assessment of human pharmaceuticals: Required changes in the new legislation	6
Systemic absorption of benzalkonium chloride after maximal use of a consumer antiseptic wash product	6
Evaluation of the safety of ethanolic extract from Piper amalago L. (Piperaceae) leaves in vivo: Subacute toxicity and genotoxicity studies	6
Grouping of chemicals based on the potential mechanisms of hepatotoxicity of naphthalene and structurally similar chemicals using in vitro testing for read-across and its validation	6
Chemical interactions and mixtures in public health risk assessment: An analysis of ATSDR's interaction profile database	6
Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum	6
Ethyl acrylate (EA) exposure and thyroid carcinogenicity in rats and mice with relevance to human health	6
Evaluation of chronic toxicity of cyclocreatine, a creatine analog, in Sprague Dawley rat after oral gavage administration for up to 26 weeks	6
Chronic aquatic toxicity assessment of diverse chemicals on Daphnia magna using QSAR and chemical read-across	6
Letter to the editor regarding Heringa et al. (2020) paper entitled “Use of the Kinetically-derived Maximum Dose concept in selection of top doses for toxicity studies hampers proper hazard assessment	6
A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 1: Bioaccessibility testing	6
“From Protein Toxins to Applied Toxicological Testing” virtual workshop identifies the need for a bioinformatic framework to assess novel food protein safety	6
A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 2 b: Reactive cobalt substances induce oxidative stress in ToxTracker and activate hypoxia target genes	6
Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice	6
Safety assessment of MPTA: An oral acute and 90-day sub-chronic toxicity study in Sprague-Dawley rats	6
Derivation of Biomonitoring Equivalents for aluminium for the interpretation of population-level biomonitoring data	6
OECD harmonised template 201: Structuring and reporting mechanistic information to foster the integration of new approach methodologies for hazard and risk assessment of chemicals	6
Carcinogenic and neurotoxic risks of acrylamide consumed through bread, kaak, toast, and crackers among the Lebanese Population	6
Genotoxicity and subchronic toxicity studies of supercritical carbon dioxide and acetone extracts of rosemary	6
Extended One-Generation Reproductive Toxicity (EOGRT) study of benzoic acid in Sprague Dawley rats	6
Reproductive and developmental toxicity screening study of an acetone extract of rosemary	6
Physiologically based pharmacokinetic combined JAK2 occupancy modelling to simulate PK and PD of baricitinib with kidney transporter inhibitors and in patients with hepatic/renal impairment	6
REACHing for solutions: Essential revisions to the EU chemicals regulation to modernise safety assessment	6
Draize human repeat insult patch test (HRIPT): Seven decades of pitfalls and progress	6
The activity of methacrylate esters in skin sensitisation test methods II. A review of complementary and additional analyses	6
Preliminary clinical pharmacokinetic evaluation of bemotrizinol - A new sunscreen active ingredient being considered for inclusion under FDA's over-the-counter (OTC) sunscreen monograph	6
Inhalation toxicity of cyclic semi-volatile methylsiloxanes: Disentangling the conundrum of phase-specific adaptations from adverse outcomes	6
DeepAmes: A deep learning-powered Ames test predictive model with potential for regulatory application	6
Retrospective analysis of the potential use of virtual control groups in preclinical toxicity assessment using the eTOX database	6
Toxicological evaluation of a glycan preparation from an enzymatic hydrolysis of Saccharomyces cerevisiae	6
Evidence-based regulations for bioinformatic prediction of allergen cross-reactivity are needed	6
Regulatory performance of the East African Community joint assessment procedure: The way forward for regulatory systems strengthening	5
Comparative In vitro metabolism of purified mogrosides derived from monk fruit extracts	5
Initial hazard assessment of ethyl(dimethyl)(tetradecyl)ammonium ethyl sulfate: Genotoxicity tests and combined repeated-dose and reproductive/developmental toxicity screening in rats	5
An integrated benefit-risk assessment of cobalt-containing alloys used in medical devices: Implications for regulatory requirements in the European Union	5
Weight of evidence and human relevance evaluation of the benfluralin mode of action in rodents (Part I): Liver carcinogenesis	5
Range of the perfluorooctanoate (PFOA) safe dose for human health: An international collaboration	5
Review of air concentrations of pesticides for estimating exposure to vapour in European risk assessments	5
Comparison of product safety data sheet ingredient lists with skin irritants and sensitizers present in a convenience sample of light-curing resins used in additive manufacturing	5
Copper alloys’ metal migration and bioaccessibility in saliva and gastric fluid	5
Isoflucypram: Combining in vivo and NAMs data in a weight of evidence approach to demonstrate the human non-relevance of the mode of action leading to the subtle thyroid effects observed in the rat	5
Computational prediction of Calu-3-based in vitro pulmonary permeability of chemicals	5
Threshold of Toxicological Concern: Extending the chemical space by inclusion of a highly curated dataset for organosilicon compounds	5
A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10	5
Probabilistic pharmacokinetic modeling of airborne lead corresponding to toxicologically relevant blood lead levels in workers	5
A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential	5
Tiered human health risk assessment of antibacterial quaternary ammonium compounds (QACs) in dishwashing detergents	5
Reference Chemical Potency List (RCPL): A new tool for evaluating the accuracy of skin sensitisation potency measurements by New Approach Methodologies (NAMs)	5
Active pharmaceutical contaminants in dietary supplements: A tier-based risk assessment approach	5
Nonclinical evaluation of abuse liability of the dual orexin receptor antagonist lemborexant	5
The SCCS scientific advice on the safety of nanomaterials in cosmetics	5
Iraqi regulatory authority current system and experience with biosimilars	5
Ethylene oxide derived glycol ethers: A review of the alkyl glycol ethers potential to cause endocrine disruption	5
Assessing biological oxidative damage induced by graphene-based materials: An asset for grouping approaches using the FRAS assay	5
Ability of mathematical models to predict human in vivo percutaneous penetration of steroids	4
Building confidence in skin sensitisation potency assessment using new approach methodologies: report of the 3rd EPAA Partners Forum, Brussels, 28th October 2019	4