OOIR: Observatory of International Research

Papers

(The H4-Index of Regulatory Toxicology and Pharmacology is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
A review of common approaches to determining allocation factors and relative source contribution factors for drinking water contaminants: caveats and areas for improvement	127
Two-year carcinogenicity study of a novel plasticizer, bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate (Eco-DEHCH), by oral diet in Han Wistar rats	106
Prevalence and sample sizes in pre-clinical studies	98
Controlling cleaning agent residues in pharmaceutical manufacturing: A harmonized scientific strategy	95
Selectively addressing total risk avoidance for certain chemicals while overlooking others: The case of per-and-poly-fluoroalkyls	95
Safety evaluation of ondansetron after gestational exposure on male reproductive parameters in rats	78
Ames mutagenicity of 15 aryl, benzyl, and aliphatic ring N-nitrosamines	76
Risk assessment and pharmacokinetic modeling of incidental ingestion of ethanol from mouthwash	73
Preclinical safety evaluation of the ethanolic extract from the aerial parts of Gomphrena celosioides Mart. in rodents	53
Is periventricular heterotopia a useful endpoint for developmental thyroid hormone system disruption in mouse toxicity studies?	49
A Cautionary tale for using read-across for cancer hazard classification: Case study of isoeugenol and methyl eugenol	49
HESI GTTC ring trial: Concordance between Ames and rodent carcinogenicity outcomes for N-nitrosamines (NAs) with rat and hamster metabolic conditions	45
Target organ toxicity in Sprague Dawley rats following oral exposure to complex groundwater mixture: Assessment of dose-response relationships using histopathological and biochemical alterations	45
Revisiting ICH S7A after 25 years: Outcomes of a multi-stakeholder workshop and strategic pillars for modernizing safety pharmacology	44
Control of N-nitrosamine impurities in drug products: Progressing the current CPCA framework and supporting the derivation of robust compound specific acceptable intakes	44
Nonclinical development of advanced therapies: Best practices for translational and regulatory success	43
Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs)	43
Editorial Board	40
Exploring the potential of ToxCast™ data for mechanism-based prioritization of chemicals in regulatory context: Case study with priority existing chemicals (PECs) under K-REACH	39
Editorial: 2024 - A promising start for regulatory toxicology and pharmacology	37
Toltrazuril sulfone (Ponazuril) residue depletion in pig tissues and estimated withdrawal intervals	37
Retraction of Williams et al. (2000) does not affect the conclusions of the 2016 FAO/WHO JMPR evaluation of glyphosate	37
Safety data sheets as an information pathway on hazards of occupationally used cleaning agents	36
Scientific considerations in the regulatory approval of generic (or biosimilar) version of enoxaparin sodium – A lifesaving carbohydrate polymer	35
Incorporating Singaporean habits and practices for cosmetics and personal care products into a global consumer aggregate exposure model	34

False positive findings associated with adenoviral vector-based vaccine underscore the regulatory necessity to eliminate abnormal toxicity test	33
Inter-species variability in 4,4′-methylenedianiline metabolism: insights from human and rat precision-cut liver slices	32
Expert panel evaluation of the tumor modes of action for 1,4-dioxane and their implications for human risk assessment	32
Importance of tailored non-clinical safety testing of novel antimalarial drugs: Industry best-practice	30
A tool to support food substance safety evaluations in the United States	30
Physiologically based pharmacokinetic modeling of oseltamivir in pregnant rhesus macaques to inform clinical dosing across trimesters	30