Drug Development Research

Article	Citations
Safety study of topical naltrexone therapy for diabetic skin wounds is confirmed in Göttingen mini‐pigs	95
Therapeutic potential and research progress of diosgenin for lipid metabolism diseases	81
Novel matrinic acid derivatives bearing 2‐anilinothiazole structure for non‐small cell lung cancer treatment with improved Hsp90 targeting effect	66
Rational Discovery of BACE1‐Selective Inhibitors as Potential Therapeutics for Alzheimer's Disease	66
Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone‐based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease	59
Trifolirhizin targets PTK6 to induce autophagy and exerts antitumor effects in nasopharyngeal carcinoma	55
Terbutaline attenuates LPS ‐induced injury of pulmonary microvascular endothelial cells by cAMP /Epac signaling	47
CircRNF121 knockdown suppresses the progression of cervical cancer by regulating miR ‐153‐3p/ ATF2 axis and	43
A growth‐based assay using fluorescent protein emission to screen for S‐adenosylmethionine synthetase inhibitors	41
Susceptibility of Leishmania to novel pentavalent organometallics: Investigating impact on DNA and membrane integrity in antimony(III)‐sensitive and ‐resistant strains	37
Research Progress of Endoplasmic Reticulum Targeting Metal Complexes in Cancer Therapy	29
Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c‐Jun Pathway	29
Knockdown of IGF2BP3 inhibits the tumorigenesis of gallbladder cancer and modifies tumor microenvironment	28
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Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases	25
Recent Development in Celiac Disease: Pathophysiology, Animal Models and Treatments	25
Advancements in Organoid‐Based Drug Discovery: Revolutionizing Precision Medicine and Pharmacology	25
Ricolinostat suppresses proliferation, promotes apoptosis, and enhances the antiproliferative activity of topoisomerase inhibitors in cervical cancer cells	24
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T‐17, a novel cyclin‐dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis	23
Xanthatin induce DDP‐resistance lung cancer cells apoptosis through regulation of GLUT1 mediated ROS accumulation	22
Dendrobine modulates autophagy to alleviate ox‐LDL‐induced oxidative stress and senescence in HUVECs	22
Recombinant human epidermal growth factor‐loaded liposomes and transferosomes for dermal delivery: Development, characterization, and cytotoxicity evaluation	22

Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents	22
Recent advancement in drug development of nitro(NO2)‐heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis	21
Irisin Protects Against Diabetic Cardiomyopathy by Suppressing Ferroptosis	21
New pyrrole derivatives as DNA gyrase and 14α‐demethylase inhibitors: Design, synthesis, antimicrobial evaluation, and molecular docking	21
Reduction‐Responsive RGD‐Docetaxel Conjugate: Synthesis, In Vitro Drug Release and In Vitro Antitumor Activity	20
Recent research brings hope for reshaping the co‐evolutionary arms race against parasitic infectious diseases	20
Does Metabolic Manager Show Encouraging Outcomes in Alzheimer's?: Challenges and Opportunity for Protein Tyrosine Phosphatase 1b Inhibitors	20
PX‐12 synergistically enhances the therapeutic efficacy of vorinostat under hypoxic tumor microenvironment in oral squamous cell carcinoma in vitro	20
Repurposing Nitroimidazoles: A New Frontier in Combatting Bacterial Virulence and Quorum Sensing via In Silico, In Vitro, and In Vivo Insights	20
RecQ protein‐like 4 drives cisplatin chemosensitivity of cervical cancer cells by modulating annexin A2	20
Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells	18
In Vitro and In Silico Assessment of Antileishmanial Potential of Novel Tri‐ and Penta‐Valent Antimony Complexes With Phenolic Ligands	18
Scopoletin Mitigates DSS‐Induced Ulcerative Colitis by Attenuating NF‐κB/MMP‐9 Mediated Inflammation and Activating the Nrf2 Pathway to Preserve Colonic Barrier Integrity	18
The potential of developing a protective peptide‐based vaccines against SARS‐CoV‐2	18
Tropisetron attenuates high glucose‐induced oxidative stress and inflammation in ARPE‐19 cells in vitro via regulating SIRT1/ROCK1 signaling	18
Diaryl Diimidazopyrimidine Derivatives as Potent Inhibitors of Influenza A Virus: Synthesis, Evaluation and Docking Studies	18
An Inducible Neural Stem Progenitor Cell Model for Testing Therapeutic Interventions Against Neurodegeneration FENIB	18
Design, synthesis, and in‐silico study of novel triarylethylene analogs with dual anti‐estrogenic and serotonergic activity	17
Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors	17
Repurposing Poloxamers as Antimicrobial Agents: A Comprehensive Review of Mechanisms and Applications	17
Toad venom bufadienolides and bufotoxins: An updated review	17
Molecular Pathways in Idiopathic Pulmonary Fibrosis: A Review of Novel Insights for Drug Design	17
68Ga‐labeled, imatinib encapsulated, theranostic liposomes: Formulation, characterization, and in vitro evaluation of anticancer activity	16
Paeonol inhibits chronic constriction injury‐induced astrocytic activation and neuroinflammation in rats via the HDAC/miR‐15a pathway	16
Toosendanin inhibits colorectal cancer cell growth through the Hedgehog pathway by targeting Shh	16
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Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway	16
Selective carbonic anhydrase IX and XII inhibitors based around a functionalized coumarin scaffold	15
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Imidazolidine‐Based Aspartate Inhibitors for Candida Infections	15
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Everolimus inhibits hepatoblastoma by inducing autophagy‐dependent ferroptosis	14
Upregulation of FGF9 and NOVA1 in cancer‐associated fibroblasts promotes cell proliferation, invasion and migration of triple negative breast cancer	14
89Zr‐Labeled DFO@Durvalumab‐HSA nanoparticles: In vitro potential for triple‐negative breast cancer	13
Costunolide attenuates high‐fat diet‐induced inflammation and oxidative stress in non‐alcoholic fatty liver disease	13
Nitroimidazole derivatives potentiated against tumor hypoxia: Design, synthesis, antitumor activity, molecular docking study, and QSAR study	13
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Synthetic amino acids‐based short amphipathic peptides exhibit antifungal activity by targeting cell membrane disruption	13
Formulation characterization of lecithin organogel as topical drug delivery system for psoriasis: In‐vitro permeation and preclinical evaluation	13
New Ester‐Containing Azole Derivatives With Potent Anti‐Candida Effects: Synthesis, Antifungal Susceptibility, Cytotoxicity, and Molecular Modeling Studies	13
Bazedoxifene analogs as potential WDHD1 degraders and antitumor agents: Synthesis, evaluation and molecular dynamics simulation studies	13
Hirudin attenuates puromycin aminonucleoside‐induced glomerular podocyte injury by inhibiting MAPK‐mediated endoplasmic reticulum stress	13
β_lactam antibiotics against drug addiction: A novel therapeutic option	12
Allosteric modulation of SHP2: Quest from known to unknown	12
FDA Modernization Act 2.0: An insight from nondeveloping country	12
Synthesis, biological evaluation, and in silico studies of indole‐tethered pyrazoline derivatives as anticancer agents targeting topoisomerase IIα	12
Xanthatin inhibits non‐small cell lung cancer proliferation by breaking the redox balance	12
Therapeutic role of Artemether in the prevention of hepatic steatosis through miR‐34a‐5p/PPARα pathway	12
Road‐map of pre‐clinical treatment for Visceral Leishmaniasis	12
Fluorinated Sulfonamides: Synthesis, Characterization, In Silico, Molecular Docking, ADME, DFT Predictions, and Structure‐Activity Relationships, as Well as Assessments of Antimicrobial and Ant	12

Circular RNAs in the chemoresistance of triple‐negative breast cancer: A systematic review	12
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis	12
Atopic Dermatitis: Updated Insights Into Pathophysiology and Emerging Therapies	12
Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR‐2 Inhibitors Based on the Benzenesulfonamide‐Bearing 4‐Thiazolidinones/2,4‐Thiazolidinediones Scaffold	12
Races of small molecule clinical trials for the treatment of COVID‐19: An up‐to‐date comprehensive review	11
A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors	11
Deciphering chemoresistance in osteosarcoma: Unveiling regulatory mechanisms and function through the lens of noncoding RNA	11
Sodium tanshinone IIA sulfonate promotes spinal cord injury repair by inhibiting blood spinal cord barrier disruption in vitro and in vivo	11
A novel copper chelator for the suppression of colorectal cancer	11
Discovery of pyrazole‐carbohydrazide with indole moiety as tubulin polymerization inhibitors and anti‐tumor candidates	10
Rutin increases alpha‐tubulin acetylation via histone deacetylase 6 inhibition	10
Proteolysis Targeting Chimera (PROTAC) as a promising novel therapeutic modality for the treatment of triple‐negative breast cancer (TNBC)	10
Comprehensive characterization and preclinical assessment of an imidazopyridine‐based anticancer lead molecule	10
Investigation of the factors responsible for the low oral bioavailability of alizarin using a sensitive LC‐MS/MS method: In vitro, in situ, and in vivo evaluations	10
Novel Metronidazole Conjugates as Antimicrobial Agents	10
Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway	10
Explore new quinoxaline pharmacophore tethered sulfonamide fragments as in vitro α‐glucosidase, α‐amylase, and acetylcholinesterase inhibitors with ADMET and molecular modeling simulation	10
Carbamate as a potential anti‐Alzheimer's pharmacophore: A review	10
Hesperidin, vanillic acid, and sinapic acid attenuate atorvastatin‐induced mitochondrial dysfunction via inhibition of mitochondrial swelling and maintenance of mitochondrial function in pancreas isol	10
Reduced Taurine Transporter Expression in Lymphoblastoid Cell Lines From Alzheimer's Disease Patients Compared With Age‐Matched Controls: Therapeutic Implications?	10
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Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel strategy for the treatment of osteosarcoma and Ewing sarcoma	10
9‐Ethynyl noscapine induces G2 /M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer	9
Pantoprazole suppresses carcinogenesis and growth of hepatocellular carcinoma by inhibiting glycolysis and Na+/H+ exchange	9
Phytol Enhances Anticonvulsant Effect of Carbamazepine and Diazepam Against PTZ‐Induced Convulsion in Chicks, Possibly Through Voltage‐Gated Sodium Channel and GABAA Interaction Pathways	9
RETRACTION: “Dose‐dependent Chemopreventive Effects of Citronellol in DMBA‐Induced Breast Cancer Among Rats”	9
Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment	9
Structural Diversity and Mutational Challenges of Toll‐Like Receptor 4 Antagonists as Inflammatory Pathway Blocker	9
The Role of Fatty Acid Metabolism, the Related Potential Biomarkers, and Targeted Therapeutic Strategies in Gastrointestinal Cancers	9
Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB‐R signaling	9
Quinolone as a Privileged Scaffold: A Brief Overview on Early Classical and Recent Advanced Synthetic Pathways, Innovative Neuroprotective Potential, and Structure‐Activity Relationships	9
The cytotoxicity of karanjin toward breast cancer cells is involved in the PI3K/Akt signaling pathway	8
Schisandrin B ameliorates non‐alcoholic liver disease through anti‐inflammation activation in diabetic mice	8
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR‐144‐3p/IGF2R axis	8
A novel cinnamic and caffeic acid‐conjugated peptide analogs with anticonvulsant and analgesic potency: Comparative analyses of trans/cis isomers	8
Structure and activity of ananti‐epidermal growth factor receptor antibody without galactose‐α‐1,3‐galactose residues	8
Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates	8
Enriching iPSC research diversity: Harnessing human biobank collections for improved ethnic representation	8
Design and synthesis of vancomycin‐functionalized ZnFe2O4 nanoparticles as an effective antibacterial agent against methicillin‐resistant Staphylococcus aureus	8
YTHDF2 promotes gastric cancer progression and enhances chemoradiotherapy resistance	8
Fasudil attenuates syncytin‐1‐mediated activation of microglia and impairments of motor neurons and motor function in mice	8
Design, synthesis, in silico, and in vitro evaluation of novel benzyloxybenzene substituted (S)‐α‐amino amide derivatives as cholinesterases and monoaminoxidases inhibitor	8
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Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies	8
Cover Image, Volume 85, Issue 1	8
Identification of ROS and KEAP1‐related genes and verified targets of α‐hederin induce cell death for CRC	8
Kaempferitrin Regulates the Proliferation, Metastasis, and Immune Escape of Nonsmall Cell Lung Cancer by Inhibiting the Akt/NF‐κB Pathway	8
CCAR2 Drives Glioma Cell Survival by Positively Regulating SIRT1 and Activating the Notch1/c‐Myc Pathway	7
Design and synthesis of novel hexahydrobenzo[4,5]thieno[2,3‐d]pyrimidine derivatives as potential anticancer agents with antiangiogenic activity via VEGFR‐2 inhibition, and down‐regulation of P	7
Discovery of pyrazole‐1‐carboxamide derivatives as novel Gi‐biased μ‐opioid receptor agonists	7
Chitosan‐coated nanoparticles in innovative cancer bio‐medicine	7
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Targeting the Enzymatic Site of Botulinum Neurotoxin Type E With 8‐Hydroxyquinolinol–Based Inhibitors: In Silico, In Vitro, and In Vivo Evaluation	7
Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management	7
Synthesis and anti‐HIV activity of non‐nucleoside reverse‐transcriptase inhibitor DB02 phosphate derivatives based on water‐soluble optimization	7
Synthesis and In Vitro Analysis of Dual‐Functionalized Mesoporous Silica Nanoparticles for Targeted Theranosis of ER(+) Breast Cancer	7
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YTHDF2 interference suppresses the EMT of cervical cancer cells and enhances cisplatin chemosensitivity by regulating AXIN1	7
TRPM2‐AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR‐497‐5p	7
Papaverine, a promising therapeutic agent for the treatment of COVID‐19 patients with underlying cardiovascular diseases (CVDs)	7
Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolo[3,4‐b]pyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia	7
Identification of Novel Neddylation‐Related Molecular Subtypes in Non‐Small Cell Lung Cancer With Implications for Prognosis and the Immune Landscape	7
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Verbascoside enhances radiosensitivity of hepatocellular carcinoma cells through regulating miR‐101‐3p/Wee1 axis	7
Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5‐fluorouracil in rats	6
Combined chemotherapy of zoledronic acid and pamidronate in the treatment of bone metastases from nonsmall cell lung cancer and the effects on pain stress and bone metabolic indices	6
Comparative Study of Pyridine and Pyrimidine Derivatives as Promising Anti‐Inflammatory Agents: Design, Synthesis, and LPS‐Induced RAW 264.7 Macrophages	6
Downregulation of short‐stature homeobox protein 2 suppresses gastric cancer cell growth and stemness in vitro and in vivo via inactivating wnt/β‐catenin signaling	6
Paeonol inhibits human lung cancer cell viability and metastasis in vitro via miR‐126‐5p/ZEB2 axis	6
IL2‐inducible T‐cell kinase inhibitor ibrutinib reduces symptoms and Th2 differentiation in mouse allergic‐rhinitis model	6
Role of BIX01294 in the intracranial inhibition of H3K9 methylation lessens neuronal loss in vascular dementia model	6
DPP‐4 inhibitor linagliptin ameliorates imiquimod‐induced psoriasis‐like skin alterations in type 2 diabetic mice by inhibiting the MAPK/NF‐κB inflammatory pathway	6
Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav‐1 signaling	6
Unraveling the Curcumin's Molecular Targets and Its Potential in Suppressing Skin Inflammation Using Network Pharmacology and In Vitro Studies	6
Evaluation of advanced, pathophysiologic new targets for imaging of CNS	6
Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development	6
FGF12 restrains mitochondria‐dependent ferroptosis in doxorubicin‐induced cardiomyocytes through the activation of FGFR1/AMPK/NRF2 signaling	6
Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach	6
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Exploring the potential of radiolabeled duramycin as an infection imaging probe	6

Computational and experimental analyses of alanine racemase suggest new avenues for developing allosteric small‐molecule antibiotics	6
Cover Image, Volume 83, Issue 7	6
Novel EGFR‐MAPK kinase and ABC transporter inhibitors for HepG2 resistant to Erlotinib	6
Carnosol alleviates sevoflurane‑induced cognitive dysfunction by mediating NF‑κB pathway in aged rats	6
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Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence	6