Drug Development Research

Papers
(The TQCC of Drug Development Research is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics544
Androgen sensitivity gateway to COVID‐19 disease severity118
Naphthoquinones, benzoquinones, and anthraquinones: Molecular docking, ADME and inhibition studies on human serum paraoxonase‐1 associated with cardiovascular diseases82
Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID‐1969
COVID‐19 treatment by repurposing drugs until the vaccine is in sight57
Potential antiviral activity of isorhamnetin against SARS‐CoV‐2 spike pseudotyped virus in vitro48
Epigallocatechin gallate and theaflavin gallate interaction in SARS‐CoV‐2 spike‐protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular do42
Surface receptor‐mediated targeted drug delivery systems for enhanced cancer treatment: A state‐of‐the‐art review40
Challenges of peptide and protein drug delivery by oral route: Current strategies to improve the bioavailability39
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin‐4(3H)‐one derivatives as potential aldose reductase inhibitors39
The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets37
Role of mineralocorticoid receptor antagonists in kidney diseases37
Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release32
Prospects of multitarget drug designing strategies by linking molecular docking and molecular dynamics to explore the protein–ligand recognition process31
Revisiting potential druggable targets against SARS‐CoV‐2 and repurposing therapeutics under preclinical study and clinical trials: A comprehensive review28
A comprehensive review of computational techniques for the prediction of drug side effects27
Oridonin ameliorates carbon tetrachloride‐induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome26
Medicinal chemistry of anthranilic acid derivatives: A mini review26
Snake venom‐derived bradykinin‐potentiating peptides: A promising therapy for COVID‐19?25
COVID‐19 transmission through host cell directed network of GPCR23
Review of registered clinical trials for the treatment of COVID‐1922
Neuroprotective mechanisms of mangiferin in neurodegenerative diseases22
Smoking and COVID‐19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers22
Paeoniflorin inhibited nod‐like receptor protein‐3 inflammasome and NF‐κB‐mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor CXCR222
Bergenin inhibits bladder cancer progression via activating the PPARγ/PTEN/Akt signal pathway22
Osteoarthritis: Prognosis and emerging therapeutic approach for disease management21
Ginsenoside Rg3 attenuates ovariectomy‐induced osteoporosis via AMPK/mTOR signaling pathway21
Targeting cyclooxygenase enzyme for the adjuvant COVID‐19 therapy21
Hybrid molecules based on 1,3,5‐triazine as potential therapeutics: A focused review21
A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors20
Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line20
CB2 receptor‐selective agonists as candidates for targeting infection, inflammation, and immunity in SARS‐CoV‐2 infections19
An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review19
In vitro–in vivo evaluation of tetrahydrozoline‐loaded ocular in situ gels on rabbits for allergic conjunctivitis management19
Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells19
Overview of in situ gelling injectable hydrogels for diabetic wounds18
Paeonol protects melanocytes against hydrogen peroxide‐induced oxidative stress through activation of Nrf2 signaling pathway18
Therapeutic potential of targeting the receptor for advanced glycation end products (RAGE) by small molecule inhibitors18
Superiority of cilostazol among antiplatelet FDA‐approved drugs against COVID 19 Mpro and spike protein: Drug repurposing approach17
Investigation of antioxidant and anti‐nociceptive potential of isoxazolone, pyrazolone derivatives, and their molecular docking studies17
Design, synthesis, in vitro and in silico studies of novel Schiff base derivatives of 2‐hydroxy‐4‐methoxybenzamide as tyrosinase inhibitors16
Proteolysis targeting chimera (PROTAC) for epidermal growth factor receptor enhances anti‐tumor immunity in non‐small cell lung cancer16
Noscapine, a possible drug candidate for attenuation of cytokine release associated with SARS‐CoV‐216
Phytochemical conjugation as a potential semisynthetic approach toward reactive and reuse of obsolete sulfonamides against pathogenic bacteria16
Circ_0001667 knockdown blocks cancer progression and attenuates adriamycin resistance by depleting NCOA3 via releasing miR‐4458 in breast cancer16
Ropivacaine inhibits proliferation, invasion, migration and promotes apoptosis of papillary thyroid cancer cells via regulating ITGA2 expression15
Fenofibrate attenuates ischemia reperfusion‐induced acute kidney injury and associated liver dysfunction in rats15
Recent advances in trophoblast cell‐surface antigen 2 targeted therapy for solid tumors15
Lithium as a candidate treatment for COVID‐19: Promises and pitfalls15
Drug encapsulating polysaccharide‐loaded metal nanoparticles: A perspective drug delivery system15
Designing therapeutic strategies to combat severe acute respiratory syndrome coronavirus‐2 disease: COVID‐1915
HDAC6 inhibitor, ACY1215 suppress the proliferation and induce apoptosis of gallbladder cancer cells and increased the chemotherapy effect of gemcitabine and oxaliplatin14
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors14
CircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR‐665‐dependent regulation of EGFR14
Response to recent commentaries regarding the involvement of angiotensin‐converting enzyme 2 (ACE2) and renin‐angiotensin system blockers in SARS‐CoV‐2 infe14
New multitarget directed benzimidazole‐2‐thiol‐based heterocycles as prospective anti‐radical and anti‐Alzheimer's agents14
Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review14
Contribution of N‐heterocycles towards anti‐tubercular drug discovery (2014–2019); predicted and reengineered molecular frameworks14
Synthesis, characterization, and anti‐cancer activity of new chalcone derivatives containing naphthalene and fluorine moieties14
Synthesis of benzimidazole based hydrazones as non‐sugar based α‐glucosidase inhibitors: Structure activity relation and molecular docking14
Secoisolariciresinol diglucoside induces pyroptosis by activating caspase‐1 to cleave GSDMD in colorectal cancer cells14
Genetic determinants of circulating VEGF levels in major depressive disorder and electroconvulsive therapy response14
Effects of sinomenine on the proliferation, cytokine production, and regulatory T‐cell frequency in peripheral blood mononuclear cells of rheumatoid arthritis patients13
Repurposing of FDA‐approved drugs as inhibitors of sterol C‐24 methyltransferase of Leishmania donovani to fight against leishmaniasis13
Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management13
Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibiting PI3K/AKT pathway13
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities with molecular modeling13
Crocetin and related oxygen diffusion‐enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications13
Papaverine, a promising therapeutic agent for the treatment of COVID‐19 patients with underlying cardiovascular diseases (CVDs)13
Monensin inhibits proliferation, migration, and promotes apoptosis of breast cancer cells via downregulating UBA213
Approaches to minimize the effects of P‐glycoprotein in drug transport: A review13
Recent strategies for the development of oral medicines for the treatment of visceral leishmaniasis13
YTHDF2 interference suppresses the EMT of cervical cancer cells and enhances cisplatin chemosensitivity by regulating AXIN113
Association study between HTR2A rs6313 polymorphism and early response to risperidone and olanzapine in schizophrenia patients13
Conventional and microwave‐assisted organic synthesis of novel antimycobacterial agents bearing furan and pyridine hybrids12
New isolate from Salvinia molesta with antioxidant and urease inhibitory activity12
A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective12
Volatile molecules for COVID‐19: A possible pharmacological strategy?12
Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development12
Races of small molecule clinical trials for the treatment of COVID‐19: An up‐to‐date comprehensive review11
Repurposing current therapeutics for treating COVID‐19: A vital role of prescription records data mining11
An outlook on procedures of conjugating folate to (co)polymers and drugs for effective cancer targeting11
Neratinib inhibits proliferation and promotes apoptosis of acute myeloid leukemia cells by activating autophagy‐dependent ferroptosis11
“Azole” as privileged heterocycle for targeting the inducible cyclooxygenase enzyme11
Anatomical distribution and expression of CYP in humans: Neuropharmacological implications11
Step toward repurposing drug discovery for COVID‐19 therapeutics through in silico approach11
Effects of different doses of atorvastatin, rosuvastatin, and simvastatin on elderly patients with ST‐elevation acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI)10
Phosphate moiety in FDA‐approved pharmaceutical salts and prodrugs10
Xanthatin inhibits human colon cancer cells progression via mTOR signaling mediated energy metabolism alteration10
ORY‐1001, a KDM1A inhibitor, inhibits proliferation, and promotes apoptosis of triple negative breast cancer cells by inactivating androgen receptor10
Therapeutic delivery with V‐amylose10
Evaluation of the neuropharmacological effects of Gardenin A in mice10
Oridonin alleviates d‐GalN/LPS‐induced acute liver injury by inhibiting NLRP3 inflammasome10
The mechanism of Arhalofenate in alleviating hyperuricemia―Activating PPARγ thereby reducing caspase‐1 activity10
Discovery of substituted indole derivatives as allosteric inhibitors ofm6A‐RNAmethyltransferase,METTL3‐14 complex9
PMEPA1 interference activates PTEN/PI3K/AKT, thereby inhibiting the proliferation, invasion and migration of pancreatic cancer cells and enhancing the sensi9
Dendrobine modulates autophagy to alleviate ox‐LDL‐induced oxidative stress and senescence in HUVECs9
The recent development of thymol derivative as a promising pharmacological scaffold9
Synthesis and characterization of new pyrazole–tetrazole derivatives as new vasorelaxant agents9
Antibacterial azole derivatives: Antibacterial activity, cytotoxicity, and in silico mechanistic studies9
Lithium treatment in the era of personalized medicine9
Hirudin prevents vascular endothelial cell apoptosis and permeability enhancement induced by the serum from rat with chronic renal failure through inhibiting RhoA/ROCK signaling 9
Neobavaisoflavone protects osteoblasts from dexamethasone‐induced oxidative stress by upregulating the CRNDE‐mediated Nrf2/HO‐1 signaling pathway9
Synthesis of novel N‐substitutedphenyl‐6‐oxo‐3‐phenylpyridazine derivatives as cyclooxygenase‐2 inhibitors9
Emerging cases of mucormycosis under COVID‐19 pandemic in India: Misuse of antibiotics9
CircATL2 enhances paclitaxel resistance of ovarian cancer via impacting miR‐506‐3p/NFIB axis9
Propofol promotes migration, alleviates inflammation, and apoptosis of lipopolysaccharide‐induced human pulmonary microvascular endothelial cells by activating PI3K/AKT signaling9
TRPM2‐AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR‐497‐5p9
Discovery of novel indole‐1,2,4‐triazole derivatives as tubulin polymerization inhibitors9
MicroRNA‐214‐5p aggravates sepsis‐related acute kidney injury in mice8
Exosome‐mediated PROTACs delivery to target viral infections8
Design, synthesis, molecular docking, anti‐quorum sensing, and anti‐biofilm activity of pyochelin‐zingerone conjugate8
Potential of nafimidone derivatives against co‐morbidities of epilepsy: In vitro, in vivo, and in silico investigations8
CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1/2 and p38 MAPK pathway through miR‐409‐3p/CDK8 axis8
Paeonol inhibits human lung cancer cell viability and metastasis in vitro via miR‐126‐5p/ZEB2 axis8
Antiurolithiatic effects of pentacyclic triterpenes: The distance traveled from therapeutic aspects8
Marein ameliorates Ang II/hypoxia‐induced abnormal glucolipid metabolism by modulating the HIF‐1α/PPARα/γ pathway in H9c2 cells8
Design, synthesis, and structure–activity relationship of caffeine‐based triazoles as dual AChE and BACE‐1 inhibitors8
Dioscin induces osteosarcoma cell apoptosis by upregulating ROS‐mediated P38 MAPK signaling8
Circ‐OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR‐558/THBS2 axis8
Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies7
Tanshinol alleviates ulcerative colitis by promoting the expression of VLDLR7
CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR‐34a7
Butyrate prevents the migration and invasion, and aerobic glycolysis in gastric cancer via inhibiting Wnt/β‐catenin/c‐Myc signaling7
Stevioside protects against rhabdomyolysis‐induced acute kidney injury through PPAR‐γ agonism in rats7
D‐ribose‐L‐cysteine enhances memory task, attenuates oxidative stress and acetyl‐cholinesterase activity in scopolamine amnesic mice7
Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy7
Bacterial hepatocyte growth factor receptor agonist stimulates hepatocyte proliferation and accelerates liver regeneration in a partial hepatectomy rat model7
Road‐map of pre‐clinical treatment for Visceral Leishmaniasis7
Exploration of novel TOSMIC tethered imidazo[1,2‐a]pyridine compounds for the development of potential antifungal drug candidate7
Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors7
Design, synthesis, and structure–activity relationship study of O‐prenylated 3‐acetylcoumarins as potent inhibitors of soybean 15‐lipoxygenase7
Loganin exerts a protective effect on ischemia–reperfusion‐induced acute kidney injury by regulating JAK2/STAT3 and Nrf2/HO‐1 signaling pathways7
Repurposing of digoxin in pain and inflammation: An evidence‐based study7
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis7
Disruption of the biological activity of protease‐activated receptors2/4 in adults rather than children in SARS CoV‐2 virus‐mediated mortality in COVID‐19 infection7
Amino acid conjugates of 2‐mercaptobenzimidazole provide better anti‐inflammatory pharmacology and improved toxicity profile7
Irigenin alleviates angiotensin II‐induced oxidative stress and apoptosis in HUVEC cells by activating Nrf2 pathway7
Flufenamic acid alleviates sepsis‐induced lung injury by up‐regulating CBR17
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