OOIR: Observatory of International Research

Papers

(The TQCC of Drug Development Research is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Research Progress of Endoplasmic Reticulum Targeting Metal Complexes in Cancer Therapy	135
Susceptibility of Leishmania to novel pentavalent organometallics: Investigating impact on DNA and membrane integrity in antimony(III)‐sensitive and ‐resistant strains	97
Safety study of topical naltrexone therapy for diabetic skin wounds is confirmed in Göttingen mini‐pigs	78
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A growth‐based assay using fluorescent protein emission to screen for S‐adenosylmethionine synthetase inhibitors	74
Trifolirhizin targets PTK6 to induce autophagy and exerts antitumor effects in nasopharyngeal carcinoma	40
Heteromerization, Biased Agonism, and Allosteric Modulation of G Protein‐Coupled Receptors in Addiction: Mechanistic Insights and Therapeutic Implications	36
Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c‐Jun Pathway	36
Recent Development in Celiac Disease: Pathophysiology, Animal Models and Treatments	33
Knockdown of IGF2BP3 inhibits the tumorigenesis of gallbladder cancer and modifies tumor microenvironment	33
Secoisolariciresinol Diglucoside Alleviates LPS‐Induced Acute Lung Injury by Inhibiting the NF‐κB/NLRP3 Signaling Pathway	31
Synthesis and Biological Evaluation of π‐Conjugated Ir(III) Complexes: Cytotoxic Potential, DNA/HSA Binding, Thermodynamics, and Antioxidant Activity	31
Rational Discovery of BACE1‐Selective Inhibitors as Potential Therapeutics for Alzheimer's Disease	30
Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone‐based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease	29
Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases	29
Protective Effects of Herbacetin in Experimental Colitis: Targeting NF‐κB and NLRP3 Pathways	29
Therapeutic potential and research progress of diosgenin for lipid metabolism diseases	28
Ricolinostat suppresses proliferation, promotes apoptosis, and enhances the antiproliferative activity of topoisomerase inhibitors in cervical cancer cells	27
Dynorphin A Inhibits the Proliferation, Migration, Invasion, and Stemness of Triple Negative Breast Cancer Cells	27
Advancements in Organoid‐Based Drug Discovery: Revolutionizing Precision Medicine and Pharmacology	27
Does Metabolic Manager Show Encouraging Outcomes in Alzheimer's?: Challenges and Opportunity for Protein Tyrosine Phosphatase 1b Inhibitors	26
Issue Information	26
Issue Information	26
Reduction‐Responsive RGD‐Docetaxel Conjugate: Synthesis, In Vitro Drug Release and In Vitro Antitumor Activity	26
Azole Amide Analogues as Antibacterial Agents Against Methicillin‐Resistant Staphylococcus aureus and Its Structure‐Activity Relationship Studies	26

New pyrrole derivatives as DNA gyrase and 14α‐demethylase inhibitors: Design, synthesis, antimicrobial evaluation, and molecular docking	26
Lysosome‐Mediated Targeted Protein Degradation: Emerging Chimeric Platforms for Extracellular and Intracellular Therapeutics	25
Recombinant human epidermal growth factor‐loaded liposomes and transferosomes for dermal delivery: Development, characterization, and cytotoxicity evaluation	25
Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents	25
Iridium(III) Complexes for Lung Cancer Therapy: Recent Advances and Case Studies in DNA Targeting, Antioxidant Activity and Cytotoxicity	24
PX‐12 synergistically enhances the therapeutic efficacy of vorinostat under hypoxic tumor microenvironment in oral squamous cell carcinoma in vitro	23
Repurposing Nitroimidazoles: A New Frontier in Combatting Bacterial Virulence and Quorum Sensing via In Silico, In Vitro, and In Vivo Insights	22
Study on the Mechanism of Aspirin Alleviating Kawasaki Disease With Coronary Artery Lesions by Inducing TRAF6 to Regulate STAT3 Ubiquitination and Inhibit Th17 Cell Differentiation	22
Xanthatin induce DDP‐resistance lung cancer cells apoptosis through regulation of GLUT1 mediated ROS accumulation	22
Unveiling Remyelinating Properties of Roflumilast in CPZ‐Induced Neuronal Demyelination in Mice	21
Scopoletin Mitigates DSS‐Induced Ulcerative Colitis by Attenuating NF‐κB/MMP‐9 Mediated Inflammation and Activating the Nrf2 Pathway to Preserve Colonic Barrier Integrity	21
RecQ protein‐like 4 drives cisplatin chemosensitivity of cervical cancer cells by modulating annexin A2	21
Diaryl Diimidazopyrimidine Derivatives as Potent Inhibitors of Influenza A Virus: Synthesis, Evaluation and Docking Studies	21
Irisin Protects Against Diabetic Cardiomyopathy by Suppressing Ferroptosis	21
⁶⁸Ga‐labeled, imatinib encapsulated, theranostic liposomes: Formulation, characterization, and in vitro evaluation of anticancer activity	20
Tropisetron attenuates high glucose‐induced oxidative stress and inflammation in ARPE‐19 cells in vitro via regulating SIRT1/ROCK1 signaling	20
An Inducible Neural Stem Progenitor Cell Model for Testing Therapeutic Interventions Against Neurodegeneration FENIB	20
Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells	20
Repurposing Poloxamers as Antimicrobial Agents: A Comprehensive Review of Mechanisms and Applications	20
Molecular Pathways in Idiopathic Pulmonary Fibrosis: A Review of Novel Insights for Drug Design	20
Design, synthesis, and in‐silico study of novel triarylethylene analogs with dual anti‐estrogenic and serotonergic activity	20
Toad venom bufadienolides and bufotoxins: An updated review	20
Recent Progress of Molecular Design and Activities of Spleen Tyrosine Kinase (SYK) Inhibitors	19
Paeonol inhibits chronic constriction injury‐induced astrocytic activation and neuroinflammation in rats via the HDAC/miR‐15a pathway	19
Targeting Alpha‐Synuclein Aggregation With Chemical Chaperone IP‐045: An Approach to Parkinson's Disease Therapy	18
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In Vitro and In Silico Assessment of Antileishmanial Potential of Novel Tri‐ and Penta‐Valent Antimony Complexes With Phenolic Ligands	18
Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway	18
Blueprint for Drug Repurposing Success: Foundational Concepts and Practical Framework	18
Issue Information	18
New Ester‐Containing Azole Derivatives With Potent Anti‐Candida Effects: Synthesis, Antifungal Susceptibility, Cytotoxicity, and Molecular Modeling Studies	17
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Upregulation of FGF9 and NOVA1 in cancer‐associated fibroblasts promotes cell proliferation, invasion and migration of triple negative breast cancer	16
Novel 4‐chlorophenyl and 3/4‐chlorophenoxy Based Triazole/Thiazole Derivatives: Synthesis and Investigation of Their Effects on Neurodegenerative Disorders‐Related Enzymes via In Vitro and In Silico	16
Correction to “Dioscin Induces Osteosarcoma Cell Apoptosis by Upregulating Ros‐Mediated P38 Mapk Signaling”	16
Everolimus inhibits hepatoblastoma by inducing autophagy‐dependent ferroptosis	16
Bazedoxifene analogs as potential WDHD1 degraders and antitumor agents: Synthesis, evaluation and molecular dynamics simulation studies	16
Imidazolidine‐Based Aspartate Inhibitors for Candida Infections	16
Synthetic amino acids‐based short amphipathic peptides exhibit antifungal activity by targeting cell membrane disruption	15
Selective carbonic anhydrase IX and XII inhibitors based around a functionalized coumarin scaffold	15
Innovative Drug and Prodrug Candidates in Cancer Treatment Targeting TP53 Mutations: Challenge and Hope	15
Costunolide attenuates high‐fat diet‐induced inflammation and oxidative stress in non‐alcoholic fatty liver disease	14
Nitroimidazole derivatives potentiated against tumor hypoxia: Design, synthesis, antitumor activity, molecular docking study, and QSAR study	14
Formulation characterization of lecithin organogel as topical drug delivery system for psoriasis: In‐vitro permeation and preclinical evaluation	14
⁸⁹Zr‐Labeled DFO@Durvalumab‐HSA nanoparticles: In vitro potential for triple‐negative breast cancer	14
A novel copper chelator for the suppression of colorectal cancer	14
β_lactam antibiotics against drug addiction: A novel therapeutic option	14
Mechanism of Berberine Ameliorating Severe Pneumonia by Targeting PTGS2 Inhibition to Regulate C‐Type Lectin Receptor Pathway, Mitochondrial Function and Cellular Focalization	14
Targeting Autophagy in Alzheimer's Disease: Role of the AMPK/mTOR Pathway and Drug Repurposing	14
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis	14

Discovery of Novel 5‐Substituted‐4‐Allyl‐1,2,4‐Triazoles as Potential Nonsteroidal Anti‐Inflammatory Agents via Downregulation of iNOS Expression	13
Therapeutic role of Artemether in the prevention of hepatic steatosis through miR‐34a‐5p/PPARα pathway	13
Issue Information	13
Circular RNAs in the chemoresistance of triple‐negative breast cancer: A systematic review	13
FDA Modernization Act 2.0: An insight from nondeveloping country	13
TRIM26‐Mediated CBX6 Ubiquitination Triggers NETosis to Drive Bladder Cancer Tumor Growth via the CNPY2/NF‐κB Signaling Pathway	13
Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR‐2 Inhibitors Based on the Benzenesulfonamide‐Bearing 4‐Thiazolidinones/2,4‐Thiazolidinediones Scaffold	12
Deciphering chemoresistance in osteosarcoma: Unveiling regulatory mechanisms and function through the lens of noncoding RNA	12
Corrigendum to “Lansbermin‐I: A Snake Venom Disintegrin With Selective Cytotoxicity and Anti‐Adhesive Effects against Glioblastoma Cells”	12
Carbamate as a potential anti‐Alzheimer's pharmacophore: A review	12
Fluorinated Sulfonamides: Synthesis, Characterization, In Silico, Molecular Docking, ADME, DFT Predictions, and Structure‐Activity Relationships, as Well as Assessments of Antimicrobial and Ant	12
Discovery of pyrazole‐carbohydrazide with indole moiety as tubulin polymerization inhibitors and anti‐tumor candidates	12
Hesperidin, vanillic acid, and sinapic acid attenuate atorvastatin‐induced mitochondrial dysfunction via inhibition of mitochondrial swelling and maintenance of mitochondrial function in pancreas isol	12
Dehydrocorydaline in Corydalis Yanhusuo Promotes M2 Microglial Polarization and Alleviates Neuroinflammation After Cerebral Ischemia‐Reperfusion Injury by Inhibiting the JAK1/STAT3 Pathway	12
Allosteric modulation of SHP2: Quest from known to unknown	12
Atopic Dermatitis: Updated Insights Into Pathophysiology and Emerging Therapies	12
Investigation of the factors responsible for the low oral bioavailability of alizarin using a sensitive LC‐MS/MS method: In vitro, in situ, and in vivo evaluations	12
Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies	11
Reduced Taurine Transporter Expression in Lymphoblastoid Cell Lines From Alzheimer's Disease Patients Compared With Age‐Matched Controls: Therapeutic Implications?	11
Next‐Generation Proteolysis‐Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation	11
Structure‐Based Identification and Synthesis of Benzimidazole Azo–Schiff Base Derivatives as Recommended CK2 and PIM‐1 Inhibitors	11
Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment	11
Phytol Enhances Anticonvulsant Effect of Carbamazepine and Diazepam Against PTZ‐Induced Convulsion in Chicks, Possibly Through Voltage‐Gated Sodium Channel and GABA _A	11
Proteolysis Targeting Chimera (PROTAC) as a promising novel therapeutic modality for the treatment of triple‐negative breast cancer (TNBC)	11
Novel Metronidazole Conjugates as Antimicrobial Agents	11
Discovery of Tetrahydropyrrolo[3,4‐c]pyrrole‐1,3‐dione Derivatives as Novel RIPK1 Inhibitors via Pharmacophore‐Based Virtual Screening	11
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RETRACTION: “Dose‐dependent Chemopreventive Effects of Citronellol in DMBA‐Induced Breast Cancer Among Rats”	11
Santamarine Synergizes With Cisplatin via ROS/JNK Axis to Selectively Induce Apoptosis and DNA Damage in Oral Cancer Cells In Vitro	11
Targeting mTOR Kinase for Cancer Treatment: A Comprehensive Review With Clinical Insights	11
The Role of Fatty Acid Metabolism, the Related Potential Biomarkers, and Targeted Therapeutic Strategies in Gastrointestinal Cancers	11
Astragaloside IV Enhances Anti‐PD‐L1 Immunotherapy in Triple‐Negative Breast Cancer by Activating the cGAS‐STING Pathway	10
Pantoprazole suppresses carcinogenesis and growth of hepatocellular carcinoma by inhibiting glycolysis and Na⁺/H⁺ exchange	10
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Synthesis and anti‐HIV activity of non‐nucleoside reverse‐transcriptase inhibitor DB02 phosphate derivatives based on water‐soluble optimization	10
Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway	10
Quinolone as a Privileged Scaffold: A Brief Overview on Early Classical and Recent Advanced Synthetic Pathways, Innovative Neuroprotective Potential, and Structure‐Activity Relationships	10
Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates	10
Rational Design of Triazole Hydrazide Derivatives With Imidazo[2,1‐ b ]thiazole Scaffolds as Targeted EGFR Inhibitors in NSCLC	10
Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel strategy for the treatment of osteosarcoma and Ewing sarcoma	10
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Cover Image, Volume 85, Issue 1	10
Unraveling Key Genes Related to Fatty Acid Metabolism in Neuropathic Pain	10
Explore new quinoxaline pharmacophore tethered sulfonamide fragments as in vitro α‐glucosidase, α‐amylase, and acetylcholinesterase inhibitors with ADMET and molecular modeling simulation	10
Comprehensive characterization and preclinical assessment of an imidazopyridine‐based anticancer lead molecule	10
Structural Diversity and Mutational Challenges of Toll‐Like Receptor 4 Antagonists as Inflammatory Pathway Blocker	10
Discovery of pyrazole‐1‐carboxamide derivatives as novel Gi‐biased μ‐opioid receptor agonists	10
Ceritinib Induces Mitochondrial Fragmentation in Thyroid Cancer Cells by Targeting Drp‐1	10
YTHDF2 promotes gastric cancer progression and enhances chemoradiotherapy resistance	9
Overcoming Resistance in EGFR‐Mutant Cancers: A Comprehensive Review of Inhibitor Evolution and SAR‐Based Design	9
Identification of ROS and KEAP1‐related genes and verified targets of α‐hederin induce cell death for CRC	9
A novel cinnamic and caffeic acid‐conjugated peptide analogs with anticonvulsant and analgesic potency: Comparative analyses of trans/cis isomers	9
CCAR2 Drives Glioma Cell Survival by Positively Regulating SIRT1 and Activating the Notch1/c‐Myc Pathway	9
Design and Development of PLGA‐PEG‐FA Nanoparticles Encapsulating Noscapinoids for Receptor‐Mediated Breast Cancer Treatment	9
Enriching iPSC research diversity: Harnessing human biobank collections for improved ethnic representation	9
The cytotoxicity of karanjin toward breast cancer cells is involved in the PI3K/Akt signaling pathway	9
Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolo[3,4‐b]pyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia	9
Design and synthesis of vancomycin‐functionalized ZnFe₂O₄ nanoparticles as an effective antibacterial agent against methicillin‐resistant Staphylococcus aureus	9
Targeting the Enzymatic Site of Botulinum Neurotoxin Type E With 8‐Hydroxyquinolinol–Based Inhibitors: In Silico, In Vitro, and In Vivo Evaluation	9
Design, synthesis, in silico, and in vitro evaluation of novel benzyloxybenzene substituted (S)‐α‐amino amide derivatives as cholinesterases and monoaminoxidases inhibitor	9
Combined chemotherapy of zoledronic acid and pamidronate in the treatment of bone metastases from nonsmall cell lung cancer and the effects on pain stress and bone metabolic indices	8
Ameliorative Effects of a Naphthoquinone Derivative With β‐Amyloid Aggregation Inhibitory Activity on Cognitive Impairment and Metabolite Analysis of the Blood and Brains of Mice	8
Fasudil attenuates syncytin‐1‐mediated activation of microglia and impairments of motor neurons and motor function in mice	8
Lead Discovery via Scaffold Refinement: Structure‐Guided Optimization of 1,2,4‐Triazolo[1,5‐ a ]Pyrimidine	8
Downregulation of short‐stature homeobox protein 2 suppresses gastric cancer cell growth and stemness in vitro and in vivo via inactivating wnt/β‐catenin signaling	8
TNFRSF17 Knockdown Alleviates Mitochondrial Dysfunction and Inflammation in COPD Through Suppression of the JAK2/STAT3 Pathway	8
Tramiprosate, the Active Agent of ALZ‐801, Modulates Amyloidogenic APP Processing and Tau Phosphorylation in a Cellular Model of Alzheimer's Disease	8
Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5‐fluorouracil in rats	8
Cover Image, Volume 83, Issue 7	8
Exploring the potential of radiolabeled duramycin as an infection imaging probe	8
Design and synthesis of novel hexahydrobenzo[4,5]thieno[2,3‐d]pyrimidine derivatives as potential anticancer agents with antiangiogenic activity via VEGFR‐2 inhibition, and down‐regulation of P	8
Kaempferitrin Regulates the Proliferation, Metastasis, and Immune Escape of Nonsmall Cell Lung Cancer by Inhibiting the Akt/NF‐κB Pathway	8
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Identification of Novel Neddylation‐Related Molecular Subtypes in Non‐Small Cell Lung Cancer With Implications for Prognosis and the Immune Landscape	8
Synthesis and In Vitro Analysis of Dual‐Functionalized Mesoporous Silica Nanoparticles for Targeted Theranosis of ER(+) Breast Cancer	8
Kv1.3 Channel Blockade by Dalfampridine Attenuates NLRP3 Inflammasome‐Driven Demyelination via the NEK7/Ripk1/FADD Pathway, Matching the Efficacy of Broad P2X7 Antagonism by Suramin in EAE	8
Computational and experimental analyses of alanine racemase suggest new avenues for developing allosteric small‐molecule antibiotics	8
Issue Information	8
Potent Therapeutic Efficacy of 9‐Bromo‐Noscapine Against Breast Cancer Cells Via Enhanced Bioavailability of the Noscapine‐Cyclodextrin Inclusion Complex	8
New Treatment Approach Using Peptoid‐Based Vaccines in Parkinson's Disease	8

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Chitosan‐coated nanoparticles in innovative cancer bio‐medicine	8
Evaluation of advanced, pathophysiologic new targets for imaging of CNS	8
Structure‐Guided Design and Mechanistic Elucidation of New Chromene Derivatives as Selective Vascular Endothelial Growth Factor Receptor‐2 Inhibitors With Potent Anticancer Activity	8
Beyond the Forest Plot: Redefining Model‐Based Meta‐Analysis as a Quantitative Engine for Model‐Informed Drug Development	8
MORC2 Recruits Tumor‐Associated Macrophages and Inhibits Pyroptosis Through Activating the Wnt/β‐Catenin Pathway in Breast Can	8
Ferrocene–Pyrazole Hybrid Induces Ferroptosis and Metabolic Disruption in Pancreatic Cancer	7
Issue Information	7
Issue Information	7
From Cancer to Neuroprotection: Pazopanib Modulates the RIPK1/RIPK3/MLKL and PGAM5/DRP1 Pathways in 3‐ Nitropropionic Acid‐Induced Huntington's Disease	7
Butyrate prevents the migration and invasion, and aerobic glycolysis in gastric cancer via inhibiting Wnt/β‐catenin/c‐Myc signaling	7
Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development	7
Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach	7
Oleuropein Modulates Mitophagy and Metabolism in Cardiomyocyte Via the PINK1/Parkin Signaling Pathway	7
Vitexicarpin Directly Targets RSK2 to Attenuate Migration and Invasion of Triple‐Negative Breast Cancer Through Modulating HIF‐1α/MMP‐9 Pathway	7
Role of BIX01294 in the intracranial inhibition of H3K9 methylation lessens neuronal loss in vascular dementia model	7
Unraveling the Curcumin's Molecular Targets and Its Potential in Suppressing Skin Inflammation Using Network Pharmacology and In Vitro Studies	7
Design, Synthesis, In Silico Profiling, and In Vitro Anticancer Assessment of Azine‐Linked Thiazolo[3,2‐a]benzimidazoles as CDK2‐Directed Therapeutic Candidates	7
Comparative Study of Pyridine and Pyrimidine Derivatives as Promising Anti‐Inflammatory Agents: Design, Synthesis, and LPS‐Induced RAW 264.7 Macrophages	7
Novel EGFR‐MAPK kinase and ABC transporter inhibitors for HepG2 resistant to Erlotinib	7
Shikonin potentiates therapeutic efficacy of oxaliplatin through reactive oxygen species‐mediated intrinsic apoptosis and endoplasmic reticulum stress in oxaliplatin‐resistant colorectal cancer cells	7
Design, Synthesis, In Vitro and In Vivo Biological Evaluation of Novel Pyrazolo[3,4‐ d ]Pyrimidine‐Based Derivatives as Promising Multitarget Candidates	7
Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence	7
Discovery of 1‐(arylacetyl)‐2‐phenyl‐pyrrolidine Derivatives as Novel POLθ‐pol Inhibitors via Structure‐Based Virtual Screening and Fragment Fusion	7
Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents	7
FAM64A aggravates proliferation, invasion, lipid droplet formation, and chemoresistance in gastric cancer: A biomarker for aggressiveness and a gene therapy target	7