OOIR: Observatory of International Research

Papers

(The TQCC of Drug Development Research is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Challenges of peptide and protein drug delivery by oral route: Current strategies to improve the bioavailability	57
Potential antiviral activity of isorhamnetin against SARS‐CoV‐2 spike pseudotyped virus in vitro	53
Surface receptor‐mediated targeted drug delivery systems for enhanced cancer treatment: A state‐of‐the‐art review	46
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin‐4(3H)‐one derivatives as potential aldose reductase inhibitors	41
Role of mineralocorticoid receptor antagonists in kidney diseases	40
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities with molecular modeling	38
Medicinal chemistry of anthranilic acid derivatives: A mini review	36
Neuroprotective mechanisms of mangiferin in neurodegenerative diseases	29
A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors	28
Paeoniflorin inhibited nod‐like receptor protein‐3 inflammasome and NF‐κB‐mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor CXCR2	27
Review of registered clinical trials for the treatment of COVID‐19	25
Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells	25
A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective	25
Overview of in situ gelling injectable hydrogels for diabetic wounds	25
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors	24
Therapeutic potential of targeting the receptor for advanced glycation end products (RAGE) by small molecule inhibitors	24
An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review	24
CB2 receptor‐selective agonists as candidates for targeting infection, inflammation, and immunity in SARS‐CoV‐2 infections	23
Targeting cyclooxygenase enzyme for the adjuvant COVID‐19 therapy	23
Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line	23
Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review	22
Drug encapsulating polysaccharide‐loaded metal nanoparticles: A perspective drug delivery system	21
Circ_0001667 knockdown blocks cancer progression and attenuates adriamycin resistance by depleting NCOA3 via releasing miR‐4458 in breast cancer	21
Approaches to minimize the effects of P‐glycoprotein in drug transport: A review	21
Proteolysis targeting chimera (PROTAC) for epidermal growth factor receptor enhances anti‐tumor immunity in non‐small cell lung cancer	20

Recent advances in trophoblast cell‐surface antigen 2 targeted therapy for solid tumors	20
YTHDF2 interference suppresses the EMT of cervical cancer cells and enhances cisplatin chemosensitivity by regulating AXIN1	19
Secoisolariciresinol diglucoside induces pyroptosis by activating caspase‐1 to cleave GSDMD in colorectal cancer cells	19
Paeonol protects melanocytes against hydrogen peroxide‐induced oxidative stress through activation of Nrf2 signaling pathway	19
Fenofibrate attenuates ischemia reperfusion‐induced acute kidney injury and associated liver dysfunction in rats	19
Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management	18
Contribution of N‐heterocycles towards anti‐tubercular drug discovery (2014–2019); predicted and reengineered molecular frameworks	18
Design, synthesis, in vitro and in silico studies of novel Schiff base derivatives of 2‐hydroxy‐4‐methoxybenzamide as tyrosinase inhibitors	18
Combination of chemotherapy and gaseous signaling molecular therapy: Novel β‐elemene nitric oxide donor derivatives against leukemia	17
Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development	17
HDAC6 inhibitor, ACY1215 suppress the proliferation and induce apoptosis of gallbladder cancer cells and increased the chemotherapy effect of gemcitabine and oxaliplatin	17
Crocetin and related oxygen diffusion‐enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications	16
CircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR‐665‐dependent regulation of EGFR	16
Races of small molecule clinical trials for the treatment of COVID‐19: An up‐to‐date comprehensive review	16
Therapeutic delivery with V‐amylose	16
Neratinib inhibits proliferation and promotes apoptosis of acute myeloid leukemia cells by activating autophagy‐dependent ferroptosis	16
Artificial intelligence revolutionizing drug development: Exploring opportunities and challenges	15
Anatomical distribution and expression of CYP in humans: Neuropharmacological implications	15
Repurposing of FDA‐approved drugs as inhibitors of sterol C‐24 methyltransferase of Leishmania donovani to fight against leishmaniasis	15
Synthesis of benzimidazole based hydrazones as non‐sugar based α‐glucosidase inhibitors: Structure activity relation and molecular docking	15
TRPM2‐AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR‐497‐5p	14
Discovery of novel indole‐1,2,4‐triazole derivatives as tubulin polymerization inhibitors	14
Xanthatin inhibits human colon cancer cells progression via mTOR signaling mediated energy metabolism alteration	14
Papaverine, a promising therapeutic agent for the treatment of COVID‐19 patients with underlying cardiovascular diseases (CVDs)	14
Exosome‐mediated PROTACs delivery to target viral infections	14
Repurposing of digoxin in pain and inflammation: An evidence‐based study	14
CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1/2 and p38 MAPK pathway through miR‐409‐3p/CDK8 axis	13
Conventional and microwave‐assisted organic synthesis of novel antimycobacterial agents bearing furan and pyridine hybrids	13
Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy	13
Discovery of substituted indole derivatives as allosteric inhibitors ofm⁶A‐RNAmethyltransferase,METTL3‐14 complex	13
Sophoraflavanone G suppresses the progression of triple‐negative breast cancer via the inactivation of EGFR–PI3K–AKT signaling	13
Oridonin alleviates d‐GalN/LPS‐induced acute liver injury by inhibiting NLRP3 inflammasome	13
MicroRNA‐214‐5p aggravates sepsis‐related acute kidney injury in mice	13
Butyrate prevents the migration and invasion, and aerobic glycolysis in gastric cancer via inhibiting Wnt/β‐catenin/c‐Myc signaling	13
Toad venom bufadienolides and bufotoxins: An updated review	13
Progress of small molecules for targeted protein degradation: PROTACs and other technologies	12
Dendrobine modulates autophagy to alleviate ox‐LDL‐induced oxidative stress and senescence in HUVECs	12
New isolate from Salvinia molesta with antioxidant and urease inhibitory activity	12
Step toward repurposing drug discovery for COVID‐19 therapeutics through in silico approach	12
“Azole” as privileged heterocycle for targeting the inducible cyclooxygenase enzyme	12
A new series of thiazole‐hydrazone hybrids for Akt‐targeted therapy of non‐small cell lung cancer	12
PMEPA1 interference activates PTEN/PI3K/AKT, thereby inhibiting the proliferation, invasion and migration of pancreatic cancer cells and enhancing the sensi	12
Phosphate moiety in FDA‐approved pharmaceutical salts and prodrugs	12
ORY‐1001, a KDM1A inhibitor, inhibits proliferation, and promotes apoptosis of triple negative breast cancer cells by inactivating androgen receptor	11
The recent development of thymol derivative as a promising pharmacological scaffold	11
Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies	11
Design, synthesis, and structure–activity relationship of caffeine‐based triazoles as dual AChE and BACE‐1 inhibitors	11
CircATL2 enhances paclitaxel resistance of ovarian cancer via impacting miR‐506‐3p/NFIB axis	11
Propofol promotes migration, alleviates inflammation, and apoptosis of lipopolysaccharide‐induced human pulmonary microvascular endothelial cells by activating PI3K/AKT signaling	11
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis	11

Neobavaisoflavone protects osteoblasts from dexamethasone‐induced oxidative stress by upregulating the CRNDE‐mediated Nrf2/HO‐1 signaling pathway	11
Marein ameliorates AngII/hypoxia‐induced abnormal glucolipid metabolism by modulating theHIF‐1α/PPARα/γ pathway in H9c2 cells	11
Oleanolic acid reduces oxidative stress and neuronal apoptosis after experimental subarachnoid hemorrhage by regulating Nrf2/ HO ‐1 pathway	10
Synthesis and characterization of new pyrazole–tetrazole derivatives as new vasorelaxant agents	10
A novel copper chelator for the suppression of colorectal cancer	10
Hirudin prevents vascular endothelial cell apoptosis and permeability enhancement induced by the serum from rat with chronic renal failure through inhibiting RhoA/ROCK signaling	10
CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR‐34a	10
α‐Pinene inhibits the growth of cervical cancer cells through its proapoptotic activity by regulating the miR‐34a‐5p/Bcl‐2 signaling axis	10
Design, synthesis, molecular docking, anti‐quorum sensing, and anti‐biofilm activity of pyochelin‐zingerone conjugate	9
Synthesis and evaluation of 2‐(4‐[4‐acetylpiperazine‐1‐carbonyl] phenyl)‐1H‐benzo[d]imidazole‐4‐carboxamide derivatives as potential PARP‐1 inhibitors and preliminary study on st	9
Emerging cases of mucormycosis under COVID‐19 pandemic in India: Misuse of antibiotics	9
Paeonol inhibits human lung cancer cell viability and metastasis in vitro via miR‐126‐5p/ZEB2 axis	9
Circ‐OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR‐558/THBS2 axis	9
Design, synthesis, and biological evaluation of thienopyrimidine derivatives as multifunctional agents against Alzheimer's disease	9
Dioscin induces osteosarcoma cell apoptosis by upregulating ROS‐mediated P38 MAPK signaling	9
Toosendanin inhibits colorectal cancer cell growth through the Hedgehog pathway by targeting Shh	9
Comprehensive investigations for a potential natural prophylaxis—A cellular and murine model for apple cider vinegar against hydrogen peroxide and scopolamine induced oxidative stress	9
Celastrol: A lead compound that inhibits SARS‐CoV‐2 replication, the activity of viral and human cysteine proteases, and virus‐induced IL‐6 secretion	9
Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav‐1 signaling	9
Effects of notoginsenoside R1 on attenuating depressive behavior induced by chronic stress in rats through induction of PI3K/AKT/NF‐κB pathway	8
Antibacterial and anti‐inflammatory activity of valproic acid‐pyrazole conjugates as a potential agent against periodontitis	8
Xanthatin inhibits non‐small cell lung cancer proliferation by breaking the redox balance	8
Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies	8
Peimine‐induced apoptosis and inhibition of migration by regulating reactive oxygen species‐mediated MAPK/STAT3/NF‐κB and Wnt/β‐catenin signaling pathways in gastric cancer MKN‐45 cells	8
Circ_0002099 is a novel molecular therapeutic target for bladder cancer	8
Exploration of novel TOSMIC tethered imidazo[1,2‐a]pyridine compounds for the development of potential antifungal drug candidate	8
Tanshinol alleviates ulcerative colitis by promoting the expression of VLDLR	8
Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors	8
Design, synthesis, and structure–activity relationship study of O‐prenylated 3‐acetylcoumarins as potent inhibitors of soybean 15‐lipoxygenase	8
Loganin exerts a protective effect on ischemia–reperfusion‐induced acute kidney injury by regulating JAK2/STAT3 and Nrf2/HO‐1 signaling pathways	8
Prolyl hydroxylase inhibitor desidustat protects against acute and chronic kidney injury by reducing inflammatory cytokines and oxidative stress	8
Disruption of the biological activity of protease‐activated receptors2/4 in adults rather than children in SARS CoV‐2 virus‐mediated mortality in COVID‐19 infection	8
Road‐map of pre‐clinical treatment for Visceral Leishmaniasis	8
Irigenin alleviates angiotensin II‐induced oxidative stress and apoptosis in HUVEC cells by activating Nrf2 pathway	8
PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA‐induced granulosa cell apoptosis in vitro	8
Potential of nafimidone derivatives against co‐morbidities of epilepsy: In vitro, in vivo, and in silico investigations	8
New chromanone derivatives containing thiazoles: Synthesis and antitumor activity evaluation on A549 lung cancer cell line	7
Benzoxazolone‐arylpiperazinyl scaffold‐based PET ligand for 5‐HT₇: Synthesis and biological evaluation	7
Solasonine alleviates high glucose‐induced podocyte injury through increasing Nrf2‐medicated inhibition of NLRP3 activation	7
Calycosin represses AIM2 inflammasome‐mediated inflammation and pyroptosis to attenuate monosodium urate‐induced gouty arthritis through NF‐κB and p62‐Keap1 pathways	7
Alpha‐lipoic acid: A promising adjuvant for nonsteroidal anti‐inflammatory drugs therapy with improved efficacy and gastroprotection	7
Sodium Danshensu inhibits the progression of lung cancer by regulating PI3K/Akt signaling pathway	7
Naringin treatment improved main clozapine‐induced adverse effects in rats; emphasis on weight gain, metabolic abnormalities, and agranulocytosis	7
Novel matrinic acid derivatives bearing 2‐anilinothiazole structure for non‐small cell lung cancer treatment with improved Hsp90 targeting effect	7
Apigenin inhibits isoproterenol‐induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR‐122‐5p/155‐5p expressions	7
Palmatine attenuates hepatocyte injury by promoting autophagy via the AMPK/mTOR pathway after alcoholic liver disease	7
Versatile use of Carmofur: A comprehensive review of its chemistry and pharmacology	7
Ombuin ameliorates diabetic nephropathy in rats by anti‐inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways	7
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR‐144‐3p/IGF2R axis	7
Protection of clozapine‐induced oxidative stress and mitochondrial dysfunction by kaempferol in rat cardiomyocytes	7
Daphnetin inhibits the survival of hepatocellular carcinoma cells through regulating Wnt/β‐catenin signaling pathway	7
Berberine targets KIF20A and CCNE2 to inhibit the progression of nonsmall cell lung cancer via the PI3K/AKT pathway	7
Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway	7
Beta‐lactam resistance and the effectiveness of antimicrobial peptides against KPC‐producing bacteria	7
The research progress on the anxiolytic effect of plant‐derived flavonoids by regulating neurotransmitters	6
Design, synthesis, and biological evaluation of thienopyrimidine and thienotriazine derivatives as multitarget anti‐Alzheimer agents	6
Conjugates of lactobionic acid and IR820: New photosensitizers for efficient photodynamic therapy of hepatoma cells	6
Barbiturate derivatives for managing multifaceted oncogenic pathways: A mini review	6
Recent advancement in drug development of nitro(NO₂)‐heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis	6
Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway	6
Cell penetrating peptides: Highlighting points in cancer therapy	6
Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors	6
New benzothienopyrimidine derivatives as dual EGFR/ARO inhibitors: Design, synthesis, and their cytotoxic effect on MCF‐7 breast cancer cell line	6
Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities	6
Carnosol alleviates sevoflurane‑induced cognitive dysfunction by mediating NF‑κB pathway in aged rats	6
Combination of canstatin and arsenic trioxide suppresses the development of hepatocellular carcinoma	6
Two new alkaloids from Dendrobium nobile Lindl. exhibited neuroprotective activity, and dendrobine alleviated Aβ₁₋₄₂‐induced apoptosis by inhibiting CDK5 activation in PC12 cells	6
9‐Ethynyl noscapine induces G2 /M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer	6
Potential of enhancer of zeste homolog 2 inhibitors for the treatment of SWI/SNF mutant cancers and tumor microenvironment modulation	6
Cyclic carbamates in medicine: A clinical perspective	6
Pathological role of the calcium‐sensing receptor in sepsis‐induced hypotensive shock: Therapeutic possibilities and unanswered questions	6
RNA editing enzyme adenosine deaminases acting on RNA 1 deficiency increases the sensitivity of non‐small cell lung cancer cells to anlotinib by regulating CX3CR1‐fractalkine exp	6
Novel Vanillin‐based hybrids inhibit quorum sensing and silences phenotypical expressions in Pseudomonas aeruginosa	6
Hirudin attenuates puromycin aminonucleoside‐induced glomerular podocyte injury by inhibiting MAPK‐mediated endoplasmic reticulum stress	6
Design and synthesis of novel hexahydrobenzo[4,5]thieno[2,3‐d]pyrimidine derivatives as potential anticancer agents with antiangiogenic activity via VEGFR‐2 inhibition, and down‐regulation of P	6
Synthesis and in vitro antileishmanial efficacy of benzyl analogues of nifuroxazide	6
Redox‐responsive glycosylated combretastatin A‐4 derivative as novel tubulin polymerization inhibitor for glioma and drug delivery	6
Medicinal polypharmacology: Exploration and exploitation of the polypharmacolome in modern drug development	6
Design, synthesis, anticancer, and antibacterial evaluation of some quinazolinone‐based derivatives as DHFR inhibitors	6