Drug Development Research

Article	Citations
Research Progress of Endoplasmic Reticulum Targeting Metal Complexes in Cancer Therapy	123
Susceptibility of Leishmania to novel pentavalent organometallics: Investigating impact on DNA and membrane integrity in antimony(III)‐sensitive and ‐resistant strains	97
Safety study of topical naltrexone therapy for diabetic skin wounds is confirmed in Göttingen mini‐pigs	78
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A growth‐based assay using fluorescent protein emission to screen for S‐adenosylmethionine synthetase inhibitors	69
Trifolirhizin targets PTK6 to induce autophagy and exerts antitumor effects in nasopharyngeal carcinoma	50
Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases	47
Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone‐based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease	36
Knockdown of IGF2BP3 inhibits the tumorigenesis of gallbladder cancer and modifies tumor microenvironment	33
Therapeutic potential and research progress of diosgenin for lipid metabolism diseases	32
Novel matrinic acid derivatives bearing 2‐anilinothiazole structure for non‐small cell lung cancer treatment with improved Hsp90 targeting effect	30
Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c‐Jun Pathway	29
Advancements in Organoid‐Based Drug Discovery: Revolutionizing Precision Medicine and Pharmacology	29
Heteromerization, Biased Agonism, and Allosteric Modulation of G Protein‐Coupled Receptors in Addiction: Mechanistic Insights and Therapeutic Implications	29
Protective Effects of Herbacetin in Experimental Colitis: Targeting NF‐κB and NLRP3 Pathways	29
Secoisolariciresinol Diglucoside Alleviates LPS‐Induced Acute Lung Injury by Inhibiting the NF‐κB/NLRP3 Signaling Pathway	28
Synthesis and Biological Evaluation of π‐Conjugated Ir(III) Complexes: Cytotoxic Potential, DNA/HSA Binding, Thermodynamics, and Antioxidant Activity	28
Rational Discovery of BACE1‐Selective Inhibitors as Potential Therapeutics for Alzheimer's Disease	28
Recent Development in Celiac Disease: Pathophysiology, Animal Models and Treatments	28
Ricolinostat suppresses proliferation, promotes apoptosis, and enhances the antiproliferative activity of topoisomerase inhibitors in cervical cancer cells	26
T‐17, a novel cyclin‐dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis	26
Azole Amide Analogues as Antibacterial Agents Against Methicillin‐Resistant Staphylococcus aureus and Its Structure‐Activity Relationship Studies	25
Repurposing Nitroimidazoles: A New Frontier in Combatting Bacterial Virulence and Quorum Sensing via In Silico, In Vitro, and In Vivo Insights	25
Xanthatin induce DDP‐resistance lung cancer cells apoptosis through regulation of GLUT1 mediated ROS accumulation	25
Iridium(III) Complexes for Lung Cancer Therapy: Recent Advances and Case Studies in DNA Targeting, Antioxidant Activity and Cytotoxicity	25

Scopoletin Mitigates DSS‐Induced Ulcerative Colitis by Attenuating NF‐κB/MMP‐9 Mediated Inflammation and Activating the Nrf2 Pathway to Preserve Colonic Barrier Integrity	25
Dynorphin A Inhibits the Proliferation, Migration, Invasion, and Stemness of Triple Negative Breast Cancer Cells	25
Diaryl Diimidazopyrimidine Derivatives as Potent Inhibitors of Influenza A Virus: Synthesis, Evaluation and Docking Studies	25
Reduction‐Responsive RGD‐Docetaxel Conjugate: Synthesis, In Vitro Drug Release and In Vitro Antitumor Activity	25
New pyrrole derivatives as DNA gyrase and 14α‐demethylase inhibitors: Design, synthesis, antimicrobial evaluation, and molecular docking	24
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Issue Information	24
RecQ protein‐like 4 drives cisplatin chemosensitivity of cervical cancer cells by modulating annexin A2	24
Does Metabolic Manager Show Encouraging Outcomes in Alzheimer's?: Challenges and Opportunity for Protein Tyrosine Phosphatase 1b Inhibitors	23
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Study on the Mechanism of Aspirin Alleviating Kawasaki Disease With Coronary Artery Lesions by Inducing TRAF6 to Regulate STAT3 Ubiquitination and Inhibit Th17 Cell Differentiation	22
Lysosome‐Mediated Targeted Protein Degradation: Emerging Chimeric Platforms for Extracellular and Intracellular Therapeutics	22
The potential of developing a protective peptide‐based vaccines against SARS‐CoV‐2	21
PX‐12 synergistically enhances the therapeutic efficacy of vorinostat under hypoxic tumor microenvironment in oral squamous cell carcinoma in vitro	20
Recombinant human epidermal growth factor‐loaded liposomes and transferosomes for dermal delivery: Development, characterization, and cytotoxicity evaluation	20
Irisin Protects Against Diabetic Cardiomyopathy by Suppressing Ferroptosis	20
Unveiling Remyelinating Properties of Roflumilast in CPZ‐Induced Neuronal Demyelination in Mice	20
Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents	20
Tropisetron attenuates high glucose‐induced oxidative stress and inflammation in ARPE‐19 cells in vitro via regulating SIRT1/ROCK1 signaling	19
Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway	19
Repurposing Poloxamers as Antimicrobial Agents: A Comprehensive Review of Mechanisms and Applications	19
Toad venom bufadienolides and bufotoxins: An updated review	19
Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells	18
Toosendanin inhibits colorectal cancer cell growth through the Hedgehog pathway by targeting Shh	18
68Ga‐labeled, imatinib encapsulated, theranostic liposomes: Formulation, characterization, and in vitro evaluation of anticancer activity	18
Molecular Pathways in Idiopathic Pulmonary Fibrosis: A Review of Novel Insights for Drug Design	18
Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors	18
Design, synthesis, and in‐silico study of novel triarylethylene analogs with dual anti‐estrogenic and serotonergic activity	18
An Inducible Neural Stem Progenitor Cell Model for Testing Therapeutic Interventions Against Neurodegeneration FENIB	18
Recent Progress of Molecular Design and Activities of Spleen Tyrosine Kinase (SYK) Inhibitors	18
Paeonol inhibits chronic constriction injury‐induced astrocytic activation and neuroinflammation in rats via the HDAC/miR‐15a pathway	17
In Vitro and In Silico Assessment of Antileishmanial Potential of Novel Tri‐ and Penta‐Valent Antimony Complexes With Phenolic Ligands	17
Blueprint for Drug Repurposing Success: Foundational Concepts and Practical Framework	17
Issue Information	16
Upregulation of FGF9 and NOVA1 in cancer‐associated fibroblasts promotes cell proliferation, invasion and migration of triple negative breast cancer	16
New Ester‐Containing Azole Derivatives With Potent Anti‐Candida Effects: Synthesis, Antifungal Susceptibility, Cytotoxicity, and Molecular Modeling Studies	16
Targeting Alpha‐Synuclein Aggregation With Chemical Chaperone IP‐045: An Approach to Parkinson's Disease Therapy	16
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Correction to “Dioscin Induces Osteosarcoma Cell Apoptosis by Upregulating Ros‐Mediated P38 Mapk Signaling”	16
Synthetic amino acids‐based short amphipathic peptides exhibit antifungal activity by targeting cell membrane disruption	16
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Bazedoxifene analogs as potential WDHD1 degraders and antitumor agents: Synthesis, evaluation and molecular dynamics simulation studies	16
Costunolide attenuates high‐fat diet‐induced inflammation and oxidative stress in non‐alcoholic fatty liver disease	15
Novel 4‐chlorophenyl and 3/4‐chlorophenoxy Based Triazole/Thiazole Derivatives: Synthesis and Investigation of Their Effects on Neurodegenerative Disorders‐Related Enzymes via In Vitro and In Silico	15
Innovative Drug and Prodrug Candidates in Cancer Treatment Targeting TP53 Mutations: Challenge and Hope	15
Everolimus inhibits hepatoblastoma by inducing autophagy‐dependent ferroptosis	15
Selective carbonic anhydrase IX and XII inhibitors based around a functionalized coumarin scaffold	14
Atopic Dermatitis: Updated Insights Into Pathophysiology and Emerging Therapies	14
89Zr‐Labeled DFO@Durvalumab‐HSA nanoparticles: In vitro potential for triple‐negative breast cancer	14
FDA Modernization Act 2.0: An insight from nondeveloping country	14

Imidazolidine‐Based Aspartate Inhibitors for Candida Infections	14
A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors	13
Fluorinated Sulfonamides: Synthesis, Characterization, In Silico, Molecular Docking, ADME, DFT Predictions, and Structure‐Activity Relationships, as Well as Assessments of Antimicrobial and Ant	13
Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR‐2 Inhibitors Based on the Benzenesulfonamide‐Bearing 4‐Thiazolidinones/2,4‐Thiazolidinediones Scaffold	13
A novel copper chelator for the suppression of colorectal cancer	13
Nitroimidazole derivatives potentiated against tumor hypoxia: Design, synthesis, antitumor activity, molecular docking study, and QSAR study	13
Synthesis, biological evaluation, and in silico studies of indole‐tethered pyrazoline derivatives as anticancer agents targeting topoisomerase IIα	13
Deciphering chemoresistance in osteosarcoma: Unveiling regulatory mechanisms and function through the lens of noncoding RNA	13
Mechanism of Berberine Ameliorating Severe Pneumonia by Targeting PTGS2 Inhibition to Regulate C‐Type Lectin Receptor Pathway, Mitochondrial Function and Cellular Focalization	13
Therapeutic role of Artemether in the prevention of hepatic steatosis through miR‐34a‐5p/PPARα pathway	12
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis	12
Allosteric modulation of SHP2: Quest from known to unknown	12
Discovery of Novel 5‐Substituted‐4‐Allyl‐1,2,4‐Triazoles as Potential Nonsteroidal Anti‐Inflammatory Agents via Downregulation of iNOS Expression	12
Formulation characterization of lecithin organogel as topical drug delivery system for psoriasis: In‐vitro permeation and preclinical evaluation	12
TRIM26‐Mediated CBX6 Ubiquitination Triggers NETosis to Drive Bladder Cancer Tumor Growth via the CNPY2/NF‐κB Signaling Pathway	12
Issue Information	12
β_lactam antibiotics against drug addiction: A novel therapeutic option	12
Carbamate as a potential anti‐Alzheimer's pharmacophore: A review	11
Corrigendum to “Lansbermin‐I: A Snake Venom Disintegrin With Selective Cytotoxicity and Anti‐Adhesive Effects against Glioblastoma Cells”	11
Novel Metronidazole Conjugates as Antimicrobial Agents	11
Circular RNAs in the chemoresistance of triple‐negative breast cancer: A systematic review	11
Targeting mTOR Kinase for Cancer Treatment: A Comprehensive Review With Clinical Insights	11
Dehydrocorydaline in Corydalis Yanhusuo Promotes M2 Microglial Polarization and Alleviates Neuroinflammation After Cerebral Ischemia‐Reperfusion Injury by Inhibiting the JAK1/STAT3 Pathway	11
Investigation of the factors responsible for the low oral bioavailability of alizarin using a sensitive LC‐MS/MS method: In vitro, in situ, and in vivo evaluations	11
Next‐Generation Proteolysis‐Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation	11
Discovery of pyrazole‐carbohydrazide with indole moiety as tubulin polymerization inhibitors and anti‐tumor candidates	11
Hesperidin, vanillic acid, and sinapic acid attenuate atorvastatin‐induced mitochondrial dysfunction via inhibition of mitochondrial swelling and maintenance of mitochondrial function in pancreas isol	11
Reduced Taurine Transporter Expression in Lymphoblastoid Cell Lines From Alzheimer's Disease Patients Compared With Age‐Matched Controls: Therapeutic Implications?	10
Discovery of Tetrahydropyrrolo[3,4‐c]pyrrole‐1,3‐dione Derivatives as Novel RIPK1 Inhibitors via Pharmacophore‐Based Virtual Screening	10
RETRACTION: “Dose‐dependent Chemopreventive Effects of Citronellol in DMBA‐Induced Breast Cancer Among Rats”	10
Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates	10
Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway	10
Proteolysis Targeting Chimera (PROTAC) as a promising novel therapeutic modality for the treatment of triple‐negative breast cancer (TNBC)	10
Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB‐R signaling	10
Rational Design of Triazole Hydrazide Derivatives With Imidazo[2,1‐ b ]thiazole Scaffolds as Targeted EGFR Inhibitors in NSCLC	10
Pantoprazole suppresses carcinogenesis and growth of hepatocellular carcinoma by inhibiting glycolysis and Na+/H+ exchange	10
Santamarine Synergizes With Cisplatin via ROS/JNK Axis to Selectively Induce Apoptosis and DNA Damage in Oral Cancer Cells In Vitro	10
Comprehensive characterization and preclinical assessment of an imidazopyridine‐based anticancer lead molecule	10
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The Role of Fatty Acid Metabolism, the Related Potential Biomarkers, and Targeted Therapeutic Strategies in Gastrointestinal Cancers	10
Structural Diversity and Mutational Challenges of Toll‐Like Receptor 4 Antagonists as Inflammatory Pathway Blocker	10
Design, synthesis, in silico, and in vitro evaluation of novel benzyloxybenzene substituted (S)‐α‐amino amide derivatives as cholinesterases and monoaminoxidases inhibitor	9
Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment	9
Phytol Enhances Anticonvulsant Effect of Carbamazepine and Diazepam Against PTZ‐Induced Convulsion in Chicks, Possibly Through Voltage‐Gated Sodium Channel and GABA A	9
Unraveling Key Genes Related to Fatty Acid Metabolism in Neuropathic Pain	9
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Overcoming Resistance in EGFR‐Mutant Cancers: A Comprehensive Review of Inhibitor Evolution and SAR‐Based Design	9
Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolo[3,4‐b]pyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia	9
Explore new quinoxaline pharmacophore tethered sulfonamide fragments as in vitro α‐glucosidase, α‐amylase, and acetylcholinesterase inhibitors with ADMET and molecular modeling simulation	9
Astragaloside IV Enhances Anti‐PD‐L1 Immunotherapy in Triple‐Negative Breast Cancer by Activating the cGAS‐STING Pathway	9
Synthesis and anti‐HIV activity of non‐nucleoside reverse‐transcriptase inhibitor DB02 phosphate derivatives based on water‐soluble optimization	9
Discovery of pyrazole‐1‐carboxamide derivatives as novel Gi‐biased μ‐opioid receptor agonists	9
The cytotoxicity of karanjin toward breast cancer cells is involved in the PI3K/Akt signaling pathway	9
CCAR2 Drives Glioma Cell Survival by Positively Regulating SIRT1 and Activating the Notch1/c‐Myc Pathway	9
Quinolone as a Privileged Scaffold: A Brief Overview on Early Classical and Recent Advanced Synthetic Pathways, Innovative Neuroprotective Potential, and Structure‐Activity Relationships	9
Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel strategy for the treatment of osteosarcoma and Ewing sarcoma	9
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Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies	9
Cover Image, Volume 85, Issue 1	9
Identification of ROS and KEAP1‐related genes and verified targets of α‐hederin induce cell death for CRC	9
Targeting the Enzymatic Site of Botulinum Neurotoxin Type E With 8‐Hydroxyquinolinol–Based Inhibitors: In Silico, In Vitro, and In Vivo Evaluation	8
Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5‐fluorouracil in rats	8
Identification of Novel Neddylation‐Related Molecular Subtypes in Non‐Small Cell Lung Cancer With Implications for Prognosis and the Immune Landscape	8
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Cover Image, Volume 83, Issue 7	8
Lead Discovery via Scaffold Refinement: Structure‐Guided Optimization of 1,2,4‐Triazolo[1,5‐ a ]Pyrimidine	8
Potent Therapeutic Efficacy of 9‐Bromo‐Noscapine Against Breast Cancer Cells Via Enhanced Bioavailability of the Noscapine‐Cyclodextrin Inclusion Complex	8
Ceritinib Induces Mitochondrial Fragmentation in Thyroid Cancer Cells by Targeting Drp‐1	8
Enriching iPSC research diversity: Harnessing human biobank collections for improved ethnic representation	8
Discovery of 1‐(arylacetyl)‐2‐phenyl‐pyrrolidine Derivatives as Novel POLθ‐pol Inhibitors via Structure‐Based Virtual Screening and Fragment Fusion	8
Exploring the potential of radiolabeled duramycin as an infection imaging probe	8
Evaluation of advanced, pathophysiologic new targets for imaging of CNS	8
Combined chemotherapy of zoledronic acid and pamidronate in the treatment of bone metastases from nonsmall cell lung cancer and the effects on pain stress and bone metabolic indices	8
Downregulation of short‐stature homeobox protein 2 suppresses gastric cancer cell growth and stemness in vitro and in vivo via inactivating wnt/β‐catenin signaling	8
Fasudil attenuates syncytin‐1‐mediated activation of microglia and impairments of motor neurons and motor function in mice	8
Design and synthesis of novel hexahydrobenzo[4,5]thieno[2,3‐d]pyrimidine derivatives as potential anticancer agents with antiangiogenic activity via VEGFR‐2 inhibition, and down‐regulation of P	8
Design and Development of PLGA‐PEG‐FA Nanoparticles Encapsulating Noscapinoids for Receptor‐Mediated Breast Cancer Treatment	8
Design and synthesis of vancomycin‐functionalized ZnFe2O4 nanoparticles as an effective antibacterial agent against methicillin‐resistant Staphylococcus aureus	8
New Treatment Approach Using Peptoid‐Based Vaccines in Parkinson's Disease	8
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A novel cinnamic and caffeic acid‐conjugated peptide analogs with anticonvulsant and analgesic potency: Comparative analyses of trans/cis isomers	8
Issue Information	8
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR‐144‐3p/IGF2R axis	8
Kaempferitrin Regulates the Proliferation, Metastasis, and Immune Escape of Nonsmall Cell Lung Cancer by Inhibiting the Akt/NF‐κB Pathway	8
YTHDF2 promotes gastric cancer progression and enhances chemoradiotherapy resistance	8
Papaverine, a promising therapeutic agent for the treatment of COVID‐19 patients with underlying cardiovascular diseases (CVDs)	8
Synthesis and In Vitro Analysis of Dual‐Functionalized Mesoporous Silica Nanoparticles for Targeted Theranosis of ER(+) Breast Cancer	7
Carnosol alleviates sevoflurane‑induced cognitive dysfunction by mediating NF‑κB pathway in aged rats	7
Issue Information	7
Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence	7
Design, Synthesis, In Silico Profiling, and In Vitro Anticancer Assessment of Azine‐Linked Thiazolo[3,2‐a]benzimidazoles as CDK2‐Directed Therapeutic Candidates	7
Comparative Study of Pyridine and Pyrimidine Derivatives as Promising Anti‐Inflammatory Agents: Design, Synthesis, and LPS‐Induced RAW 264.7 Macrophages	7
Beyond the Forest Plot: Redefining Model‐Based Meta‐Analysis as a Quantitative Engine for Model‐Informed Drug Development	7
Chitosan‐coated nanoparticles in innovative cancer bio‐medicine	7
Oleuropein Modulates Mitophagy and Metabolism in Cardiomyocyte Via the PINK1/Parkin Signaling Pathway	7
Issue Information	7
Synthesis, Biological Evaluation and Molecular Docking Studies of New 4‐(Cyanomethyl)‐ N' ‐Substituted Benzohydrazide Derivatives as Anti‐Alzheimer Agent	7
MORC2 Recruits Tumor‐Associated Macrophages and Inhibits Pyroptosis Through Activating the Wnt/β‐Catenin Pathway in Breast Can	7
Ferrocene–Pyrazole Hybrid Induces Ferroptosis and Metabolic Disruption in Pancreatic Cancer	7
From Cancer to Neuroprotection: Pazopanib Modulates the RIPK1/RIPK3/MLKL and PGAM5/DRP1 Pathways in 3‐ Nitropropionic Acid‐Induced Huntington's Disease	7
Computational and experimental analyses of alanine racemase suggest new avenues for developing allosteric small‐molecule antibiotics	7
Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development	7
Structure‐Guided Design and Mechanistic Elucidation of New Chromene Derivatives as Selective Vascular Endothelial Growth Factor Receptor‐2 Inhibitors With Potent Anticancer Activity	7
Shikonin potentiates therapeutic efficacy of oxaliplatin through reactive oxygen species‐mediated intrinsic apoptosis and endoplasmic reticulum stress in oxaliplatin‐resistant colorectal cancer cells	7
Role of BIX01294 in the intracranial inhibition of H3K9 methylation lessens neuronal loss in vascular dementia model	7
DPP‐4 inhibitor linagliptin ameliorates imiquimod‐induced psoriasis‐like skin alterations in type 2 diabetic mice by inhibiting the MAPK/NF‐κB inflammatory pathway	7
Kv1.3 Channel Blockade by Dalfampridine Attenuates NLRP3 Inflammasome‐Driven Demyelination via the NEK7/Ripk1/FADD Pathway, Matching the Efficacy of Broad P2X7 Antagonism by Suramin in EAE	7
TNFRSF17 Knockdown Alleviates Mitochondrial Dysfunction and Inflammation in COPD Through Suppression of the JAK2/STAT3 Pathway	7
Unraveling the Curcumin's Molecular Targets and Its Potential in Suppressing Skin Inflammation Using Network Pharmacology and In Vitro Studies	7