Drug Development Research

Article	Citations
Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics	544
Androgen sensitivity gateway to COVID‐19 disease severity	118
Naphthoquinones, benzoquinones, and anthraquinones: Molecular docking, ADME and inhibition studies on human serum paraoxonase‐1 associated with cardiovascular diseases	82
Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID‐19	69
COVID‐19 treatment by repurposing drugs until the vaccine is in sight	57
Potential antiviral activity of isorhamnetin against SARS‐CoV‐2 spike pseudotyped virus in vitro	48
Epigallocatechin gallate and theaflavin gallate interaction in SARS‐CoV‐2 spike‐protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular do	42
Surface receptor‐mediated targeted drug delivery systems for enhanced cancer treatment: A state‐of‐the‐art review	40
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin‐4(3H)‐one derivatives as potential aldose reductase inhibitors	39
Challenges of peptide and protein drug delivery by oral route: Current strategies to improve the bioavailability	39
Role of mineralocorticoid receptor antagonists in kidney diseases	37
The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets	37
Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release	32
Prospects of multitarget drug designing strategies by linking molecular docking and molecular dynamics to explore the protein–ligand recognition process	31
Revisiting potential druggable targets against SARS‐CoV‐2 and repurposing therapeutics under preclinical study and clinical trials: A comprehensive review	28
A comprehensive review of computational techniques for the prediction of drug side effects	27
Oridonin ameliorates carbon tetrachloride‐induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome	26
Medicinal chemistry of anthranilic acid derivatives: A mini review	26
Snake venom‐derived bradykinin‐potentiating peptides: A promising therapy for COVID‐19?	25
COVID‐19 transmission through host cell directed network of GPCR	23
Review of registered clinical trials for the treatment of COVID‐19	22
Neuroprotective mechanisms of mangiferin in neurodegenerative diseases	22
Smoking and COVID‐19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers	22
Paeoniflorin inhibited nod‐like receptor protein‐3 inflammasome and NF‐κB‐mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor CXCR2	22
Bergenin inhibits bladder cancer progression via activating the PPARγ/PTEN/Akt signal pathway	22

Osteoarthritis: Prognosis and emerging therapeutic approach for disease management	21
Ginsenoside Rg3 attenuates ovariectomy‐induced osteoporosis via AMPK/mTOR signaling pathway	21
Targeting cyclooxygenase enzyme for the adjuvant COVID‐19 therapy	21
Hybrid molecules based on 1,3,5‐triazine as potential therapeutics: A focused review	21
A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors	20
Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line	20
In vitro–in vivo evaluation of tetrahydrozoline‐loaded ocular in situ gels on rabbits for allergic conjunctivitis management	19
Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells	19
CB2 receptor‐selective agonists as candidates for targeting infection, inflammation, and immunity in SARS‐CoV‐2 infections	19
An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review	19
Therapeutic potential of targeting the receptor for advanced glycation end products (RAGE) by small molecule inhibitors	18
Overview of in situ gelling injectable hydrogels for diabetic wounds	18
Paeonol protects melanocytes against hydrogen peroxide‐induced oxidative stress through activation of Nrf2 signaling pathway	18
Superiority of cilostazol among antiplatelet FDA‐approved drugs against COVID 19 Mpro and spike protein: Drug repurposing approach	17
Investigation of antioxidant and anti‐nociceptive potential of isoxazolone, pyrazolone derivatives, and their molecular docking studies	17
Phytochemical conjugation as a potential semisynthetic approach toward reactive and reuse of obsolete sulfonamides against pathogenic bacteria	16
Circ_0001667 knockdown blocks cancer progression and attenuates adriamycin resistance by depleting NCOA3 via releasing miR‐4458 in breast cancer	16
Design, synthesis, in vitro and in silico studies of novel Schiff base derivatives of 2‐hydroxy‐4‐methoxybenzamide as tyrosinase inhibitors	16
Proteolysis targeting chimera (PROTAC) for epidermal growth factor receptor enhances anti‐tumor immunity in non‐small cell lung cancer	16
Noscapine, a possible drug candidate for attenuation of cytokine release associated with SARS‐CoV‐2	16
Designing therapeutic strategies to combat severe acute respiratory syndrome coronavirus‐2 disease: COVID‐19	15
Ropivacaine inhibits proliferation, invasion, migration and promotes apoptosis of papillary thyroid cancer cells via regulating ITGA2 expression	15
Fenofibrate attenuates ischemia reperfusion‐induced acute kidney injury and associated liver dysfunction in rats	15
Recent advances in trophoblast cell‐surface antigen 2 targeted therapy for solid tumors	15
Lithium as a candidate treatment for COVID‐19: Promises and pitfalls	15
Drug encapsulating polysaccharide‐loaded metal nanoparticles: A perspective drug delivery system	15
HDAC6 inhibitor, ACY1215 suppress the proliferation and induce apoptosis of gallbladder cancer cells and increased the chemotherapy effect of gemcitabine and oxaliplatin	14
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors	14
CircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR‐665‐dependent regulation of EGFR	14
Response to recent commentaries regarding the involvement of angiotensin‐converting enzyme 2 (ACE2) and renin‐angiotensin system blockers in SARS‐CoV‐2 infe	14
New multitarget directed benzimidazole‐2‐thiol‐based heterocycles as prospective anti‐radical and anti‐Alzheimer's agents	14
Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review	14
Contribution of N‐heterocycles towards anti‐tubercular drug discovery (2014–2019); predicted and reengineered molecular frameworks	14
Synthesis, characterization, and anti‐cancer activity of new chalcone derivatives containing naphthalene and fluorine moieties	14
Synthesis of benzimidazole based hydrazones as non‐sugar based α‐glucosidase inhibitors: Structure activity relation and molecular docking	14
Secoisolariciresinol diglucoside induces pyroptosis by activating caspase‐1 to cleave GSDMD in colorectal cancer cells	14
Genetic determinants of circulating VEGF levels in major depressive disorder and electroconvulsive therapy response	14
Approaches to minimize the effects of P‐glycoprotein in drug transport: A review	13
Recent strategies for the development of oral medicines for the treatment of visceral leishmaniasis	13
YTHDF2 interference suppresses the EMT of cervical cancer cells and enhances cisplatin chemosensitivity by regulating AXIN1	13
Association study between HTR2A rs6313 polymorphism and early response to risperidone and olanzapine in schizophrenia patients	13
Effects of sinomenine on the proliferation, cytokine production, and regulatory T‐cell frequency in peripheral blood mononuclear cells of rheumatoid arthritis patients	13
Repurposing of FDA‐approved drugs as inhibitors of sterol C‐24 methyltransferase of Leishmania donovani to fight against leishmaniasis	13
Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management	13
Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibiting PI3K/AKT pathway	13
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities with molecular modeling	13
Crocetin and related oxygen diffusion‐enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications	13
Papaverine, a promising therapeutic agent for the treatment of COVID‐19 patients with underlying cardiovascular diseases (CVDs)	13
Monensin inhibits proliferation, migration, and promotes apoptosis of breast cancer cells via downregulating UBA2	13
Volatile molecules for COVID‐19: A possible pharmacological strategy?	12

Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development	12
Conventional and microwave‐assisted organic synthesis of novel antimycobacterial agents bearing furan and pyridine hybrids	12
New isolate from Salvinia molesta with antioxidant and urease inhibitory activity	12
A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective	12
Races of small molecule clinical trials for the treatment of COVID‐19: An up‐to‐date comprehensive review	11
Repurposing current therapeutics for treating COVID‐19: A vital role of prescription records data mining	11
An outlook on procedures of conjugating folate to (co)polymers and drugs for effective cancer targeting	11
Neratinib inhibits proliferation and promotes apoptosis of acute myeloid leukemia cells by activating autophagy‐dependent ferroptosis	11
“Azole” as privileged heterocycle for targeting the inducible cyclooxygenase enzyme	11
Anatomical distribution and expression of CYP in humans: Neuropharmacological implications	11
Step toward repurposing drug discovery for COVID‐19 therapeutics through in silico approach	11
Therapeutic delivery with V‐amylose	10
Evaluation of the neuropharmacological effects of Gardenin A in mice	10
Phosphate moiety in FDA‐approved pharmaceutical salts and prodrugs	10
The mechanism of Arhalofenate in alleviating hyperuricemia―Activating PPARγ thereby reducing caspase‐1 activity	10
Effects of different doses of atorvastatin, rosuvastatin, and simvastatin on elderly patients with ST‐elevation acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI)	10
Xanthatin inhibits human colon cancer cells progression via mTOR signaling mediated energy metabolism alteration	10
ORY‐1001, a KDM1A inhibitor, inhibits proliferation, and promotes apoptosis of triple negative breast cancer cells by inactivating androgen receptor	10
Oridonin alleviates d‐GalN/LPS‐induced acute liver injury by inhibiting NLRP3 inflammasome	10
Synthesis of novel N‐substitutedphenyl‐6‐oxo‐3‐phenylpyridazine derivatives as cyclooxygenase‐2 inhibitors	9
Emerging cases of mucormycosis under COVID‐19 pandemic in India: Misuse of antibiotics	9
CircATL2 enhances paclitaxel resistance of ovarian cancer via impacting miR‐506‐3p/NFIB axis	9
Propofol promotes migration, alleviates inflammation, and apoptosis of lipopolysaccharide‐induced human pulmonary microvascular endothelial cells by activating PI3K/AKT signaling	9
TRPM2‐AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR‐497‐5p	9
Discovery of novel indole‐1,2,4‐triazole derivatives as tubulin polymerization inhibitors	9
Discovery of substituted indole derivatives as allosteric inhibitors ofm6A‐RNAmethyltransferase,METTL3‐14 complex	9
PMEPA1 interference activates PTEN/PI3K/AKT, thereby inhibiting the proliferation, invasion and migration of pancreatic cancer cells and enhancing the sensi	9
Dendrobine modulates autophagy to alleviate ox‐LDL‐induced oxidative stress and senescence in HUVECs	9
The recent development of thymol derivative as a promising pharmacological scaffold	9
Synthesis and characterization of new pyrazole–tetrazole derivatives as new vasorelaxant agents	9
Antibacterial azole derivatives: Antibacterial activity, cytotoxicity, and in silico mechanistic studies	9
Lithium treatment in the era of personalized medicine	9
Hirudin prevents vascular endothelial cell apoptosis and permeability enhancement induced by the serum from rat with chronic renal failure through inhibiting RhoA/ROCK signaling	9
Neobavaisoflavone protects osteoblasts from dexamethasone‐induced oxidative stress by upregulating the CRNDE‐mediated Nrf2/HO‐1 signaling pathway	9
Design, synthesis, and structure–activity relationship of caffeine‐based triazoles as dual AChE and BACE‐1 inhibitors	8
Dioscin induces osteosarcoma cell apoptosis by upregulating ROS‐mediated P38 MAPK signaling	8
Circ‐OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR‐558/THBS2 axis	8
MicroRNA‐214‐5p aggravates sepsis‐related acute kidney injury in mice	8
Exosome‐mediated PROTACs delivery to target viral infections	8
Design, synthesis, molecular docking, anti‐quorum sensing, and anti‐biofilm activity of pyochelin‐zingerone conjugate	8
Potential of nafimidone derivatives against co‐morbidities of epilepsy: In vitro, in vivo, and in silico investigations	8
CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1/2 and p38 MAPK pathway through miR‐409‐3p/CDK8 axis	8
Paeonol inhibits human lung cancer cell viability and metastasis in vitro via miR‐126‐5p/ZEB2 axis	8
Antiurolithiatic effects of pentacyclic triterpenes: The distance traveled from therapeutic aspects	8
Marein ameliorates Ang II/hypoxia‐induced abnormal glucolipid metabolism by modulating the HIF‐1α/PPARα/γ pathway in H9c2 cells	8
Design, synthesis, and structure–activity relationship study of O‐prenylated 3‐acetylcoumarins as potent inhibitors of soybean 15‐lipoxygenase	7
Loganin exerts a protective effect on ischemia–reperfusion‐induced acute kidney injury by regulating JAK2/STAT3 and Nrf2/HO‐1 signaling pathways	7
Repurposing of digoxin in pain and inflammation: An evidence‐based study	7
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis	7
Disruption of the biological activity of protease‐activated receptors2/4 in adults rather than children in SARS CoV‐2 virus‐mediated mortality in COVID‐19 infection	7
Amino acid conjugates of 2‐mercaptobenzimidazole provide better anti‐inflammatory pharmacology and improved toxicity profile	7
Irigenin alleviates angiotensin II‐induced oxidative stress and apoptosis in HUVEC cells by activating Nrf2 pathway	7
Flufenamic acid alleviates sepsis‐induced lung injury by up‐regulating CBR1	7
Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies	7
Tanshinol alleviates ulcerative colitis by promoting the expression of VLDLR	7
CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR‐34a	7
Butyrate prevents the migration and invasion, and aerobic glycolysis in gastric cancer via inhibiting Wnt/β‐catenin/c‐Myc signaling	7
Stevioside protects against rhabdomyolysis‐induced acute kidney injury through PPAR‐γ agonism in rats	7
D‐ribose‐L‐cysteine enhances memory task, attenuates oxidative stress and acetyl‐cholinesterase activity in scopolamine amnesic mice	7
Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy	7
Bacterial hepatocyte growth factor receptor agonist stimulates hepatocyte proliferation and accelerates liver regeneration in a partial hepatectomy rat model	7
Road‐map of pre‐clinical treatment for Visceral Leishmaniasis	7
Exploration of novel TOSMIC tethered imidazo[1,2‐a]pyridine compounds for the development of potential antifungal drug candidate	7
Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors	7
Effects of notoginsenoside R1 on attenuating depressive behavior induced by chronic stress in rats through induction of PI3K/AKT/NF‐κB pathway	6
A new series of thiazole‐hydrazone hybrids for Akt‐targeted therapy of non‐small cell lung cancer	6
Antiparasitic activities of novel pyrimidine N‐acylhydrazone hybrids	6
Progress of small molecules for targeted protein degradation: PROTACs and other technologies	6
Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav‐1 signaling	6
Synthesis and in vitro antileishmanial efficacy of benzyl analogues of nifuroxazide	6
9‐Ethynyl noscapine induces G2 /M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer	6
Solasonine alleviates high glucose‐induced podocyte injury through increasing Nrf2‐medicated inhibition of NLRP3 activation	6
Alpha‐lipoic acid: A promising adjuvant for nonsteroidal anti‐inflammatory drugs therapy with improved efficacy and gastroprotection	6
Design, synthesis and biological evaluation of several aromatic substituted chalcones as antimalarial agents	6
Sophoraflavanone G suppresses the progression of triple‐negative breast cancer via the inactivation of EGFR–PI3K–AKT signaling	6
Toosendanin inhibits colorectal cancer cell growth through the Hedgehog pathway by targeting Shh	6
New chromanone derivatives containing thiazoles: Synthesis and antitumor activity evaluation on A549 lung cancer cell line	6
Benzoxazolone‐arylpiperazinyl scaffold‐based PET ligand for 5‐HT7: Synthesis and biological evaluation	6
Apigenin inhibits isoproterenol‐induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR‐122‐5p/155‐5p expressions	6
Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors	6

The National Institutes of Health Chemical Countermeasures Research Program (NIH CCRP): A collaborative opportunity to develop effective and accessible chemical medical countermeasures for	6
Naringin treatment improved main clozapine‐induced adverse effects in rats; emphasis on weight gain, metabolic abnormalities, and agranulocytosis	6
Probing 3CL protease: Rationally designed chemical moieties for COVID‐19	6
Redox‐responsive glycosylated combretastatin A‐4 derivative as novel tubulin polymerization inhibitor for glioma and drug delivery	6
Calcium sensing receptor hyperactivation through viral envelop protein E of SARS CoV2: A novel target for cardio‐renal damage in COVID‐19 infection	5
New benzothienopyrimidine derivatives as dual EGFR/ARO inhibitors: Design, synthesis, and their cytotoxic effect on MCF‐7 breast cancer cell line	5
Benzimidazole‐carbamate anthelmintics: Perspective candidates for the anticancer drug development	5
Palmatine attenuates hepatocyte injury by promoting autophagy via the AMPK/mTOR pathway after alcoholic liver disease	5
Discovery and s tructure–activity relationships of the quinolinequinones: Promising antimicrobial agents and mode of action evaluation	5
TWIRLS, a knowledge‐mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2	5
Recent advancement in drug development of nitro(NO2)‐heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis	5
Celastrol: A lead compound that inhibits SARS‐CoV‐2 replication, the activity of viral and human cysteine proteases, and virus‐induced IL‐6 secretion	5
Synthesis and evaluation of 2‐(4‐[4‐acetylpiperazine‐1‐carbonyl] phenyl)‐1H‐benzo[d]imidazole‐4‐carboxamide derivatives as potential PARP‐1 inhibitors and preliminary study on st	5
Versatile use of Carmofur: A comprehensive review of its chemistry and pharmacology	5
Peimine‐induced apoptosis and inhibition of migration by regulating reactive oxygen species‐mediated MAPK/STAT3/NF‐κB and Wnt/β‐catenin signaling pathways in gastric cancer MKN‐45 cells	5
Artificial intelligence revolutionizing drug development: Exploring opportunities and challenges	5
Nitrogen‐containing flavonoid and their analogs with diverse B‐ring in acetylcholinesterase and butyrylcholinesterase inhibition	5
Phase I safety, tolerability, and pharmacokinetic studies of tetramethylpyrazine nitrone in healthy Chinese volunteers	5
Calcium sensing receptor as a novel target for treatment of sepsis induced cardio‐renal syndrome: Need for exploring mechanisms	5
Sodium tanshinone IIA sulfonate promotes spinal cord injury repair by inhibiting blood spinal cord barrier disruption in vitro and in vivo	5
Sodium Danshensu inhibits the progression of lung cancer by regulating PI3K/Akt signaling pathway	5
Design, synthesis, and biological evaluation of thienopyrimidine derivatives as multifunctional agents against Alzheimer's disease	5
Comprehensive investigations for a potential natural prophylaxis—A cellular and murine model for apple cider vinegar against hydrogen peroxide and scopolamine induced oxidative stress	5
A novel copper chelator for the suppression of colorectal cancer	5
Alzheimer's disease: A need for personalized therapeutic approaches	5
Cyclic carbamates in medicine: A clinical perspective	5
Naringenin inhibits autophagy and epithelial‐mesenchymal transition of human lens epithelial cells by regulating the Smad2/3 pathway	5
Oleanolic acid reduces oxidative stress and neuronal apoptosis after experimental subarachnoid hemorrhage by regulating Nrf2/ HO ‐1 pathway	5
A novel salvianolic acid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo	5
Potential of enhancer of zeste homolog 2 inhibitors for the treatment of SWI/SNF mutant cancers and tumor microenvironment modulation	5
Effect of non‐invasive brain stimulation on behavior and serum brain‐derived neurotrophic factor and insulin‐like growth factor‐1 levels in autistic patients	5
Prolyl hydroxylase inhibitor desidustat protects against acute and chronic kidney injury by reducing inflammatory cytokines and oxidative stress	5
Beta‐lactam resistance and the effectiveness of antimicrobial peptides against KPC‐producing bacteria	5
Cryptotanshinone ameliorates cardiac injury and cardiomyocyte apoptosis in rats with coronary microembolization	5
Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans	5
A novel series of substituted 1,2,3‐triazoles as cancer stem cell inhibitors: Synthesis and biological evaluation	5
Protection of clozapine‐induced oxidative stress and mitochondrial dysfunction by kaempferol in rat cardiomyocytes	5
Xanthatin inhibits non‐small cell lung cancer proliferation by breaking the redox balance	5
Carnosol alleviates sevoflurane‑induced cognitive dysfunction by mediating NF‑κB pathway in aged rats	4
Combination of canstatin and arsenic trioxide suppresses the development of hepatocellular carcinoma	4
The involvement of protein TNFSF18 in promoting p‐STAT1 phosphorylation to induce coronary microcirculation disturbance in atherosclerotic mouse model	4
Azithromycin inhibited oxidative stress and apoptosis of high glucose‐induced podocytes by inhibiting STAT1 pathway	4
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR‐144‐3p/IGF2R axis	4
Daphnetin inhibits the survival of hepatocellular carcinoma cells through regulating Wnt/β‐catenin signaling pathway	4
Terbutaline attenuates LPS ‐induced injury of pulmonary microvascular endothelial cells by cAMP /Epac signaling	4
β‐Glucuronidase‐ and OATP2B1‐mediated drug interaction of scutellarin in Dengzhan Xixin Injection: A formulation aspect	4
A quinazoline‐based bromodomain inhibitor, CN210, ameliorates indomethacin‐induced ileitis in mice by inhibiting inflammatory cytokine expression	4
Targeting AGE‐RAGE signaling pathway by Saxagliptin prevents myocardial injury in isoproterenol challenged diabetic rats	4
Dasatinib protects against acute respiratory distress syndrome via Nrf2‐regulated M2 macrophages polarization	4
RNA editing enzyme adenosine deaminases acting on RNA 1 deficiency increases the sensitivity of non‐small cell lung cancer cells to anlotinib by regulating CX3CR1‐fractalkine exp	4
Ulinastatin ameliorates the malignant progression of prostate cancer cells by blocking the RhoA/ROCK/NLRP3 pathway	4
Ombuin ameliorates diabetic nephropathy in rats by anti‐inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways	4
Medicinal chemistry of pyrophosphate mimics: A mini review	4
Design, synthesis, and biological evaluation of 3′,4′,5′‐trimethoxy evodiamine derivatives as potential antitumor agents	4
Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel strategy for the treatment of osteosarcoma and Ewing sarcoma	4
Circ_0002099 is a novel molecular therapeutic target for bladder cancer	4
Potential use of serum‐derived bovine immunoglobulin/protein isolate for the management of COVID‐19	4
Antibacterial and anti‐inflammatory activity of valproic acid‐pyrazole conjugates as a potential agent against periodontitis	4
Hirudin attenuates puromycin aminonucleoside‐induced glomerular podocyte injury by inhibiting MAPK‐mediated endoplasmic reticulum stress	4
Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of theAKT/Gsk‐3β signal pathway	4
Tectorigenin regulates migration, invasion, and apoptosis in dexamethasone‐induced human airway epithelial cells through up‐regulating miR‐222‐3p	4
Effect of tramadol on apoptosis and synaptogenesis in hippocampal neurons: The possible role of µ‐opioid receptor	4
Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies	4
Design of multicomponent indomethacin‐paracetamol and famotidine loaded nanoparticles for sustained and effective anti‐inflammatory therapy	4
Schizophrenia‐associated gene dysbindin‐1 and tardive dyskinesia	4
Inosine attenuates rotenone‐induced Parkinson's disease in rats by alleviating the imbalance between autophagy and apoptosis	4
Multitargeted C9‐substituted ester and ether derivatives of berberrubine for Alzheimer's disease: Design, synthesis, biological evaluation, metabolic stability, and pharmacokinetics	4
Synthesis, biological evaluation, and molecular docking study of chromen‐linked hydrazine carbothioamides as potent α‐glucosidase inhibitors	4
SOX4‐induced upregulation of ARHGAP9 promotes the progression of acute myeloid leukemia	4
Synergistic protective effects between docosahexaenoic acid and omeprazole on the gastrointestinal tract in the indomethacin‐induced injury model	4
Design, synthesis, and biological evaluation of thienopyrimidine and thienotriazine derivatives as multitarget anti‐Alzheimer agents	4
Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities	4
Autophagic and apoptotic cell death induced by the quinoline derivative 2‐(6‐methoxynaphthalen‐2‐yl)quinolin‐4‐amine in pancreatic cancer cells is via ER stress and inhibition of Akt/m	3
Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl‐3‐(1‐propionylpiperidin‐4‐yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome‐related pro‐inflammatory and anti‐in	3
Chrysin modulates protein kinase IKKε/TBK1, insulin sensitivity and hepatic fatty infiltration in diet‐induced obese mice	3
Insights into antimicrobial peptides in fighting anthrax: A review	3
Thrombospondin‐1 mimic peptide PKHB1 induced endoplasmic reticulum stress‐mediated but CD47‐independent apoptosis in non‐small cell lung cancer	3
Acetamidobenzoxazolone scaffold as a promising translocator protein (18 kDa, TSPO) marker for neuroinflammation imaging: Advancement in last decennial period	3
Evaluation of advanced, pathophysiologic new targets for imaging of CNS	3
Two new alkaloids from Dendrobium nobile Lindl. exhibited neuroprotective activity, and dendrobine alleviated Aβ1−42‐induced apoptosis by inhibiting CDK5 activation in PC12 cells	3
PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA‐induced granulosa cell apoptosis in vitro	3
Effects of toluidine blue O and methylene blue on growth and viability of pancreatic cancer cells	3
Mini review: The FDA‐approved prescription drugs that induce ovulation in women with ovulatory problems	3
Targeting TRAF3IP2 alleviates high glucose‐induced cardiomyocyte inflammation and apoptosis	3
Novel matrinic acid derivatives bearing 2‐anilinothiazole structure for non‐small cell lung cancer treatment with improved Hsp90 targeting effect	3
Barbiturate derivatives for managing multifaceted oncogenic pathways: A mini review	3
Preparation, characterization, and sonodynamic antitumor effect of the folate receptor targeted FA‐EN‐β‐CD containing hematoporphyrin in vitro	3
Macrocyclic sulfone derivatives: Synthesis, characterization, in vitro biological evaluation and molecular docking	3
Mitoquinone intravitreal injection ameliorates retinal ischemia–reperfusion injury in rats involving SIRT1 /Notch1/ NADPH axis	3
Alcohol intake potentiates clozapine adverse effects associated to CYP1A2*1C in patients with refractory psychosis	3
α‐Pinene inhibits the growth of cervical cancer cells through its proapoptotic activity by regulating the miR‐34a‐5p/Bcl‐2 signaling axis	3
Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway	3
Therapeutic dilemma in the repression of severe acute respiratory syndrome coronavirus‐2 proteome	3
Recent advances in the tumor‐penetrating peptide internalizing RGD for cancer treatment and diagnosis	3
Structural and biological survey of 7‐chloro‐4‐(piperazin‐1‐yl)quinoline and its derivatives	3