OOIR: Observatory of International Research

Papers

(The median citation count of Drug Development Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Therapeutic potential and research progress of diosgenin for lipid metabolism diseases	117
Research Progress of Endoplasmic Reticulum Targeting Metal Complexes in Cancer Therapy	97
Susceptibility of Leishmania to novel pentavalent organometallics: Investigating impact on DNA and membrane integrity in antimony(III)‐sensitive and ‐resistant strains	78
Safety study of topical naltrexone therapy for diabetic skin wounds is confirmed in Göttingen mini‐pigs	71
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A growth‐based assay using fluorescent protein emission to screen for S‐adenosylmethionine synthetase inhibitors	50
Trifolirhizin targets PTK6 to induce autophagy and exerts antitumor effects in nasopharyngeal carcinoma	47
Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases	35
Recent Development in Celiac Disease: Pathophysiology, Animal Models and Treatments	33
Synthesis and Biological Evaluation of π‐Conjugated Ir(III) Complexes: Cytotoxic Potential, DNA/HSA Binding, Thermodynamics, and Antioxidant Activity	30
Knockdown of IGF2BP3 inhibits the tumorigenesis of gallbladder cancer and modifies tumor microenvironment	29
Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone‐based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease	29
Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c‐Jun Pathway	28
Heteromerization, Biased Agonism, and Allosteric Modulation of G Protein‐Coupled Receptors in Addiction: Mechanistic Insights and Therapeutic Implications	28
Rational Discovery of BACE1‐Selective Inhibitors as Potential Therapeutics for Alzheimer's Disease	28
Novel matrinic acid derivatives bearing 2‐anilinothiazole structure for non‐small cell lung cancer treatment with improved Hsp90 targeting effect	27
Secoisolariciresinol Diglucoside Alleviates LPS‐Induced Acute Lung Injury by Inhibiting the NF‐κB/NLRP3 Signaling Pathway	27
Protective Effects of Herbacetin in Experimental Colitis: Targeting NF‐κB and NLRP3 Pathways	27
Advancements in Organoid‐Based Drug Discovery: Revolutionizing Precision Medicine and Pharmacology	27
T‐17, a novel cyclin‐dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis	26
The potential of developing a protective peptide‐based vaccines against SARS‐CoV‐2	25
Azole Amide Analogues as Antibacterial Agents Against Methicillin‐Resistant Staphylococcus aureus and Its Structure‐Activity Relationship Studies	25
Xanthatin induce DDP‐resistance lung cancer cells apoptosis through regulation of GLUT1 mediated ROS accumulation	25
Dynorphin A Inhibits the Proliferation, Migration, Invasion, and Stemness of Triple Negative Breast Cancer Cells	25
Ricolinostat suppresses proliferation, promotes apoptosis, and enhances the antiproliferative activity of topoisomerase inhibitors in cervical cancer cells	25

PX‐12 synergistically enhances the therapeutic efficacy of vorinostat under hypoxic tumor microenvironment in oral squamous cell carcinoma in vitro	24
Iridium(III) Complexes for Lung Cancer Therapy: Recent Advances and Case Studies in DNA Targeting, Antioxidant Activity and Cytotoxicity	24
Diaryl Diimidazopyrimidine Derivatives as Potent Inhibitors of Influenza A Virus: Synthesis, Evaluation and Docking Studies	24
Issue Information	24
Reduction‐Responsive RGD‐Docetaxel Conjugate: Synthesis, In Vitro Drug Release and In Vitro Antitumor Activity	24
Issue Information	23
RecQ protein‐like 4 drives cisplatin chemosensitivity of cervical cancer cells by modulating annexin A2	23
Issue Information	22
Irisin Protects Against Diabetic Cardiomyopathy by Suppressing Ferroptosis	22
Does Metabolic Manager Show Encouraging Outcomes in Alzheimer's?: Challenges and Opportunity for Protein Tyrosine Phosphatase 1b Inhibitors	22
New pyrrole derivatives as DNA gyrase and 14α‐demethylase inhibitors: Design, synthesis, antimicrobial evaluation, and molecular docking	22
Lysosome‐Mediated Targeted Protein Degradation: Emerging Chimeric Platforms for Extracellular and Intracellular Therapeutics	22
Study on the Mechanism of Aspirin Alleviating Kawasaki Disease With Coronary Artery Lesions by Inducing TRAF6 to Regulate STAT3 Ubiquitination and Inhibit Th17 Cell Differentiation	21
Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents	20
Recombinant human epidermal growth factor‐loaded liposomes and transferosomes for dermal delivery: Development, characterization, and cytotoxicity evaluation	20
Repurposing Nitroimidazoles: A New Frontier in Combatting Bacterial Virulence and Quorum Sensing via In Silico, In Vitro, and In Vivo Insights	20
Scopoletin Mitigates DSS‐Induced Ulcerative Colitis by Attenuating NF‐κB/MMP‐9 Mediated Inflammation and Activating the Nrf2 Pathway to Preserve Colonic Barrier Integrity	20
Toad venom bufadienolides and bufotoxins: An updated review	19
Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway	19
In Vitro and In Silico Assessment of Antileishmanial Potential of Novel Tri‐ and Penta‐Valent Antimony Complexes With Phenolic Ligands	19
Design, synthesis, and in‐silico study of novel triarylethylene analogs with dual anti‐estrogenic and serotonergic activity	18
⁶⁸Ga‐labeled, imatinib encapsulated, theranostic liposomes: Formulation, characterization, and in vitro evaluation of anticancer activity	18
Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors	18
Tropisetron attenuates high glucose‐induced oxidative stress and inflammation in ARPE‐19 cells in vitro via regulating SIRT1/ROCK1 signaling	18
Repurposing Poloxamers as Antimicrobial Agents: A Comprehensive Review of Mechanisms and Applications	18
Paeonol inhibits chronic constriction injury‐induced astrocytic activation and neuroinflammation in rats via the HDAC/miR‐15a pathway	17
Recent Progress of Molecular Design and Activities of Spleen Tyrosine Kinase (SYK) Inhibitors	17
Blueprint for Drug Repurposing Success: Foundational Concepts and Practical Framework	17
An Inducible Neural Stem Progenitor Cell Model for Testing Therapeutic Interventions Against Neurodegeneration FENIB	17
Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells	17
Toosendanin inhibits colorectal cancer cell growth through the Hedgehog pathway by targeting Shh	17
Molecular Pathways in Idiopathic Pulmonary Fibrosis: A Review of Novel Insights for Drug Design	17
Targeting Alpha‐Synuclein Aggregation With Chemical Chaperone IP‐045: An Approach to Parkinson's Disease Therapy	17
Issue Information	16
Imidazolidine‐Based Aspartate Inhibitors for Candida Infections	16
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Synthetic amino acids‐based short amphipathic peptides exhibit antifungal activity by targeting cell membrane disruption	16
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Bazedoxifene analogs as potential WDHD1 degraders and antitumor agents: Synthesis, evaluation and molecular dynamics simulation studies	15
New Ester‐Containing Azole Derivatives With Potent Anti‐Candida Effects: Synthesis, Antifungal Susceptibility, Cytotoxicity, and Molecular Modeling Studies	15
Selective carbonic anhydrase IX and XII inhibitors based around a functionalized coumarin scaffold	15
Correction to “Dioscin Induces Osteosarcoma Cell Apoptosis by Upregulating Ros‐Mediated P38 Mapk Signaling”	15
Novel 4‐chlorophenyl and 3/4‐chlorophenoxy Based Triazole/Thiazole Derivatives: Synthesis and Investigation of Their Effects on Neurodegenerative Disorders‐Related Enzymes via In Vitro and In Silico	15
Upregulation of FGF9 and NOVA1 in cancer‐associated fibroblasts promotes cell proliferation, invasion and migration of triple negative breast cancer	15
Costunolide attenuates high‐fat diet‐induced inflammation and oxidative stress in non‐alcoholic fatty liver disease	14
⁸⁹Zr‐Labeled DFO@Durvalumab‐HSA nanoparticles: In vitro potential for triple‐negative breast cancer	14
Innovative Drug and Prodrug Candidates in Cancer Treatment Targeting TP53 Mutations: Challenge and Hope	14
Everolimus inhibits hepatoblastoma by inducing autophagy‐dependent ferroptosis	14
Formulation characterization of lecithin organogel as topical drug delivery system for psoriasis: In‐vitro permeation and preclinical evaluation	14
Allosteric modulation of SHP2: Quest from known to unknown	13

FDA Modernization Act 2.0: An insight from nondeveloping country	13
A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors	12
Atopic Dermatitis: Updated Insights Into Pathophysiology and Emerging Therapies	12
Therapeutic role of Artemether in the prevention of hepatic steatosis through miR‐34a‐5p/PPARα pathway	12
Fluorinated Sulfonamides: Synthesis, Characterization, In Silico, Molecular Docking, ADME, DFT Predictions, and Structure‐Activity Relationships, as Well as Assessments of Antimicrobial and Ant	12
Synthesis, biological evaluation, and in silico studies of indole‐tethered pyrazoline derivatives as anticancer agents targeting topoisomerase IIα	12
Mechanism of Berberine Ameliorating Severe Pneumonia by Targeting PTGS2 Inhibition to Regulate C‐Type Lectin Receptor Pathway, Mitochondrial Function and Cellular Focalization	12
Deciphering chemoresistance in osteosarcoma: Unveiling regulatory mechanisms and function through the lens of noncoding RNA	12
A novel copper chelator for the suppression of colorectal cancer	12
Circular RNAs in the chemoresistance of triple‐negative breast cancer: A systematic review	12
Nitroimidazole derivatives potentiated against tumor hypoxia: Design, synthesis, antitumor activity, molecular docking study, and QSAR study	12
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis	12
β_lactam antibiotics against drug addiction: A novel therapeutic option	11
Investigation of the factors responsible for the low oral bioavailability of alizarin using a sensitive LC‐MS/MS method: In vitro, in situ, and in vivo evaluations	11
Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR‐2 Inhibitors Based on the Benzenesulfonamide‐Bearing 4‐Thiazolidinones/2,4‐Thiazolidinediones Scaffold	11
Corrigendum to “Lansbermin‐I: A Snake Venom Disintegrin With Selective Cytotoxicity and Anti‐Adhesive Effects against Glioblastoma Cells”	11
Proteolysis Targeting Chimera (PROTAC) as a promising novel therapeutic modality for the treatment of triple‐negative breast cancer (TNBC)	11
Carbamate as a potential anti‐Alzheimer's pharmacophore: A review	11
Discovery of pyrazole‐carbohydrazide with indole moiety as tubulin polymerization inhibitors and anti‐tumor candidates	11
Next‐Generation Proteolysis‐Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation	11
Hesperidin, vanillic acid, and sinapic acid attenuate atorvastatin‐induced mitochondrial dysfunction via inhibition of mitochondrial swelling and maintenance of mitochondrial function in pancreas isol	11
Reduced Taurine Transporter Expression in Lymphoblastoid Cell Lines From Alzheimer's Disease Patients Compared With Age‐Matched Controls: Therapeutic Implications?	11
Dehydrocorydaline in Corydalis Yanhusuo Promotes M2 Microglial Polarization and Alleviates Neuroinflammation After Cerebral Ischemia‐Reperfusion Injury by Inhibiting the JAK1/STAT3 Pathway	11
Discovery of Tetrahydropyrrolo[3,4‐c]pyrrole‐1,3‐dione Derivatives as Novel RIPK1 Inhibitors via Pharmacophore‐Based Virtual Screening	11
Novel Metronidazole Conjugates as Antimicrobial Agents	11
Quinolone as a Privileged Scaffold: A Brief Overview on Early Classical and Recent Advanced Synthetic Pathways, Innovative Neuroprotective Potential, and Structure‐Activity Relationships	10
Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway	10
Pantoprazole suppresses carcinogenesis and growth of hepatocellular carcinoma by inhibiting glycolysis and Na⁺/H⁺ exchange	10
Targeting mTOR Kinase for Cancer Treatment: A Comprehensive Review With Clinical Insights	10
Comprehensive characterization and preclinical assessment of an imidazopyridine‐based anticancer lead molecule	10
Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB‐R signaling	10
Structural Diversity and Mutational Challenges of Toll‐Like Receptor 4 Antagonists as Inflammatory Pathway Blocker	10
Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies	10
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RETRACTION: “Dose‐dependent Chemopreventive Effects of Citronellol in DMBA‐Induced Breast Cancer Among Rats”	10
Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates	10
Rational Design of Triazole Hydrazide Derivatives With Imidazo[2,1‐ b ]thiazole Scaffolds as Targeted EGFR Inhibitors in NSCLC	9
Explore new quinoxaline pharmacophore tethered sulfonamide fragments as in vitro α‐glucosidase, α‐amylase, and acetylcholinesterase inhibitors with ADMET and molecular modeling simulation	9
Design, synthesis, in silico, and in vitro evaluation of novel benzyloxybenzene substituted (S)‐α‐amino amide derivatives as cholinesterases and monoaminoxidases inhibitor	9
Cover Image, Volume 85, Issue 1	9
Papaverine, a promising therapeutic agent for the treatment of COVID‐19 patients with underlying cardiovascular diseases (CVDs)	9
Synthesis and anti‐HIV activity of non‐nucleoside reverse‐transcriptase inhibitor DB02 phosphate derivatives based on water‐soluble optimization	9
Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment	9
Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel strategy for the treatment of osteosarcoma and Ewing sarcoma	9
Discovery of pyrazole‐1‐carboxamide derivatives as novel Gi‐biased μ‐opioid receptor agonists	9
Overcoming Resistance in EGFR‐Mutant Cancers: A Comprehensive Review of Inhibitor Evolution and SAR‐Based Design	9
Fasudil attenuates syncytin‐1‐mediated activation of microglia and impairments of motor neurons and motor function in mice	9
The Role of Fatty Acid Metabolism, the Related Potential Biomarkers, and Targeted Therapeutic Strategies in Gastrointestinal Cancers	9
Phytol Enhances Anticonvulsant Effect of Carbamazepine and Diazepam Against PTZ‐Induced Convulsion in Chicks, Possibly Through Voltage‐Gated Sodium Channel and GABA _A	9
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Enriching iPSC research diversity: Harnessing human biobank collections for improved ethnic representation	9
Targeting the Enzymatic Site of Botulinum Neurotoxin Type E With 8‐Hydroxyquinolinol–Based Inhibitors: In Silico, In Vitro, and In Vivo Evaluation	9
Unraveling the Curcumin's Molecular Targets and Its Potential in Suppressing Skin Inflammation Using Network Pharmacology and In Vitro Studies	8
Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5‐fluorouracil in rats	8
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Downregulation of short‐stature homeobox protein 2 suppresses gastric cancer cell growth and stemness in vitro and in vivo via inactivating wnt/β‐catenin signaling	8
Identification of Novel Neddylation‐Related Molecular Subtypes in Non‐Small Cell Lung Cancer With Implications for Prognosis and the Immune Landscape	8
Kaempferitrin Regulates the Proliferation, Metastasis, and Immune Escape of Nonsmall Cell Lung Cancer by Inhibiting the Akt/NF‐κB Pathway	8
YTHDF2 promotes gastric cancer progression and enhances chemoradiotherapy resistance	8
Identification of ROS and KEAP1‐related genes and verified targets of α‐hederin induce cell death for CRC	8
CCAR2 Drives Glioma Cell Survival by Positively Regulating SIRT1 and Activating the Notch1/c‐Myc Pathway	8
Issue Information	8
Discovery of 1‐(arylacetyl)‐2‐phenyl‐pyrrolidine Derivatives as Novel POLθ‐pol Inhibitors via Structure‐Based Virtual Screening and Fragment Fusion	8
Comparative Study of Pyridine and Pyrimidine Derivatives as Promising Anti‐Inflammatory Agents: Design, Synthesis, and LPS‐Induced RAW 264.7 Macrophages	8
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Design and synthesis of vancomycin‐functionalized ZnFe₂O₄ nanoparticles as an effective antibacterial agent against methicillin‐resistant Staphylococcus aureus	8
Potent Therapeutic Efficacy of 9‐Bromo‐Noscapine Against Breast Cancer Cells Via Enhanced Bioavailability of the Noscapine‐Cyclodextrin Inclusion Complex	8
The cytotoxicity of karanjin toward breast cancer cells is involved in the PI3K/Akt signaling pathway	8
A novel cinnamic and caffeic acid‐conjugated peptide analogs with anticonvulsant and analgesic potency: Comparative analyses of trans/cis isomers	8
Ceritinib Induces Mitochondrial Fragmentation in Thyroid Cancer Cells by Targeting Drp‐1	8
Cover Image, Volume 83, Issue 7	8
Exploring the potential of radiolabeled duramycin as an infection imaging probe	8
Evaluation of advanced, pathophysiologic new targets for imaging of CNS	8
Combined chemotherapy of zoledronic acid and pamidronate in the treatment of bone metastases from nonsmall cell lung cancer and the effects on pain stress and bone metabolic indices	8
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR‐144‐3p/IGF2R axis	8
Design and synthesis of novel hexahydrobenzo[4,5]thieno[2,3‐d]pyrimidine derivatives as potential anticancer agents with antiangiogenic activity via VEGFR‐2 inhibition, and down‐regulation of P	8
Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolo[3,4‐b]pyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia	8
Design and Development of PLGA‐PEG‐FA Nanoparticles Encapsulating Noscapinoids for Receptor‐Mediated Breast Cancer Treatment	8
TNFRSF17 Knockdown Alleviates Mitochondrial Dysfunction and Inflammation in COPD Through Suppression of the JAK2/STAT3 Pathway	7

Issue Information	7
Carnosol alleviates sevoflurane‑induced cognitive dysfunction by mediating NF‑κB pathway in aged rats	7
Synthesis and In Vitro Analysis of Dual‐Functionalized Mesoporous Silica Nanoparticles for Targeted Theranosis of ER(+) Breast Cancer	7
FAM64A aggravates proliferation, invasion, lipid droplet formation, and chemoresistance in gastric cancer: A biomarker for aggressiveness and a gene therapy target	7
Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence	7
Novel EGFR‐MAPK kinase and ABC transporter inhibitors for HepG2 resistant to Erlotinib	7
Butyrate prevents the migration and invasion, and aerobic glycolysis in gastric cancer via inhibiting Wnt/β‐catenin/c‐Myc signaling	7
Beyond the Forest Plot: Redefining Model‐Based Meta‐Analysis as a Quantitative Engine for Model‐Informed Drug Development	7
From Cancer to Neuroprotection: Pazopanib Modulates the RIPK1/RIPK3/MLKL and PGAM5/DRP1 Pathways in 3‐ Nitropropionic Acid‐Induced Huntington's Disease	7
Issue Information	7
DPP‐4 inhibitor linagliptin ameliorates imiquimod‐induced psoriasis‐like skin alterations in type 2 diabetic mice by inhibiting the MAPK/NF‐κB inflammatory pathway	7
Pathological role of the calcium‐sensing receptor in sepsis‐induced hypotensive shock: Therapeutic possibilities and unanswered questions	7
Shikonin potentiates therapeutic efficacy of oxaliplatin through reactive oxygen species‐mediated intrinsic apoptosis and endoplasmic reticulum stress in oxaliplatin‐resistant colorectal cancer cells	7
FGF12 restrains mitochondria‐dependent ferroptosis in doxorubicin‐induced cardiomyocytes through the activation of FGFR1/AMPK/NRF2 signaling	7
Chitosan‐coated nanoparticles in innovative cancer bio‐medicine	7
Computational and experimental analyses of alanine racemase suggest new avenues for developing allosteric small‐molecule antibiotics	7
Role of BIX01294 in the intracranial inhibition of H3K9 methylation lessens neuronal loss in vascular dementia model	7
Oleuropein Modulates Mitophagy and Metabolism in Cardiomyocyte Via the PINK1/Parkin Signaling Pathway	7
Design, Synthesis, In Silico Profiling, and In Vitro Anticancer Assessment of Azine‐Linked Thiazolo[3,2‐a]benzimidazoles as CDK2‐Directed Therapeutic Candidates	7
Ferrocene–Pyrazole Hybrid Induces Ferroptosis and Metabolic Disruption in Pancreatic Cancer	7
Synthesis, Biological Evaluation and Molecular Docking Studies of New 4‐(Cyanomethyl)‐ N' ‐Substituted Benzohydrazide Derivatives as Anti‐Alzheimer Agent	7
Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development	7
Esketamine Protects the Blood–Brain Barrier Against Sepsis‐Associated Brain Injury by Regulating the BDNF/TrkB Pathway	6
Nanoparticle‐Integrated Transdermal Patches: A Platform for Next‐Generation Drug Delivery	6
Vitexicarpin Directly Targets RSK2 to Attenuate Migration and Invasion of Triple‐Negative Breast Cancer Through Modulating HIF‐1α/MMP‐9 Pathway	6
Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach	6
Identification of aryl hydrocarbon receptor allosteric antagonists from clinically approved drugs	6
Issue Information	6
Icaritin‐Loaded Liposomes Mediated by Hyaluronic Acid Promoted the Anti‐Proliferation and Senescence in Huh7 Cells	6
The current perspective and opportunities of small nucleic acid‐based therapeutics	6
Targeting the NLRP3 Inflammasome: Novel Inhibitors for Cardiovascular Diseases Management — A Narrative Review	6
ZPI prevents ox‐LDL‐mediated endothelial injury leading to inhibition of EndMT, inflammation, apoptosis, and oxidative stress through activating Pi3k/Akt signal pathway	6
Exploring new quinazolin‐4(3H)‐one derivatives as CDK2 inhibitors: Design, synthesis, and anticancer evaluation	6
Comparative anticonvulsant activity of the GABAkine KRM‐II‐81 and a deuterated analog	6
A Decade of Mitochondria‐Targeting Drugs in Cancer Treatment: Case Review on Mitochondria‐Targeting Curcumin or Mitocurcumin	6
Design, Synthesis, and Evaluation of Benzimidazole‐Carbazole Hybrids Targeting Heat Shock Proteins‐Mediated Apoptosis in Breast and Colon Cancer Cells	6
A Novel Oxo‐Palmatine Derivative 2q as Potent Reversal Agents Against Alzheimer's Disease	6
The contribution of the WNT pathway to the therapeutic effects of montelukast in experimental murine airway inflammation induced by ovalbumin and lipopolysaccharide	6
Thiazole‐Semicarbazone Hybrids as Dual‐Stage Inhibitors of Leishmania major Growth: Design, Synthesis, and Mechanistic Insights	6
Design, synthesis, molecular modeling, in vitro evaluation of novel piperidine‐containing hydrazone derivatives as cholinesterase inhibitors	6
Emerging in Diabetic Cardiomyopathy: Molecular Pathways and Targets for Therapeutic Intervention	6
Novel sulfonamide‐phosphonate conjugates as carbonic anhydrase isozymes inhibitors	6
Design, Synthesis, In Vitro and In Vivo Biological Evaluation of Novel Pyrazolo[3,4‐ d ]Pyrimidine‐Based Derivatives as Promising Multitarget Candidates	6
Experimentation of Heterocycles (2013‐22) as Potent Pharmacophores in Drug Design of Multiple Sclerosis	6
A new series of thiazole‐hydrazone hybrids for Akt‐targeted therapy of non‐small cell lung cancer	6
Synthesis and evaluation of [¹⁷⁷Lu]Lu‐labeled porphyrin loaded PAMAM dendrimer: Impact on tumor uptake and pharmacokinetics	6
Issue Information	6
Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues	6
PTC‐Assisted Chemoselective S ‐Alkylation of 5‐Mercapto‐1,3,4‐Oxadiazol Derivative: Multi‐Target Anticancer via EGFR, Telomerase, and Thymidylate Synthas	5
The HSP90 inhibitor 17‐AAG induced calcium‐mediated apoptosis in filarial parasites	5
Evaluation of Pyrrolone‐Fused Benzosuberene MK2 Inhibitors as Promising Therapeutic Agents for HNSCC: In Vitro Efficacy, In‐Vivo Safety, and Pharmacokinetic Profiling	5
α‐Pinene inhibits the growth of cervical cancer cells through its proapoptotic activity by regulating the miR‐34a‐5p/Bcl‐2 signaling axis	5
Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms	5
Design, synthesis, and biological evaluation of pleuromutilin derivatives containing 1,2,4‐triazole linker	5
Investigation of New Biologically Active Benzo[4,5]imidazo[1,2‐ a ]pyrimidine Derivatives as Broad‐Spectrum Antimicrobial Agents: Synthesis, Anti‐Biofilm	5
Management of Alzheimer's Disease With Nanotechnological Interventions and Novel Therapeutics	5
Issue Information	5
Issue Information	5
CRISPR Targeting the 5′ Regulatory Region of FOXM1 Will Also Disrupt RHNO1	5
Investigating the Impact of B Cell‐Related Genes on Colorectal Cancer Immunosuppressive Environment and Immunotherapy Evasion	5
Involvement of matrix metalloproteinase 1 and urokinase‐type plasminogen activator in the PKCα‐p38 MAPK pathway‐mediated progression of human liver cancer cells	5
Carboxymethyl Starch: A Contemporary Paradigm for Anti Cancer Drug Delivery	5
Novel Antioxidant Quinazoline Sulfonamide Derivatives Acting Through NQO1 Induction and Their Radiation‐Based Biodistribution Studies	5
Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival	5
Issue Information	5
Synthesis and investigation of the cholinesterase inhibitory and antioxidant capacities of some novel N'‐(quinolin‐4‐ylmethylene)propanehydrazides against Alzheimer's disease	5
Design and synthesis of guaianolide‐germacranolide heterodimers as novel anticancer agents against hepatocellular carcinoma	5
Circ_0002099 is a novel molecular therapeutic target for bladder cancer	5
RETRACTION: to “Oleanolic Acid Reduces Oxidative Stress and Neuronal Apoptosis After Experimental Subarachnoid Hemorrhage by Regulating Nrf2/HO‐1 Pathway”	5
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Phosphate moiety in FDA‐approved pharmaceutical salts and prodrugs	5
PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA‐induced granulosa cell apoptosis in vitro	5
Anlotinib improves bile duct ligature‐induced liver fibrosis in rats via antiangiogenesis regulated by VEGFR2/mTOR pathway	5
Calycosin represses AIM2 inflammasome‐mediated inflammation and pyroptosis to attenuate monosodium urate‐induced gouty arthritis through NF‐κB and p62‐Keap1 pathways	5
Issue Information	5
Bulk Microarray and Single‐Cell Transcriptomic Analyses Reveal Bacterial Lipopolysaccharide‐Related Biomarkers in Sepsis	5
Peimine‐induced apoptosis and inhibition of migration by regulating reactive oxygen species‐mediated MAPK/STAT3/NF‐κB and Wnt/β‐catenin signaling pathways in gastric cancer MKN‐45 cells	5
Halting Tuberculosis in Its Tracks: Advances and Strategies for Discovering Therapeutic Targets in Mycobacterium tuberculosis	5
Tirbanibulin (KX2‐391) analog KX2‐361 inhibits botulinum neurotoxin serotype A mediated SNAP‐25 cleavage in pre‐ and post‐intoxication models in cells	5
Berberine targets KIF20A and CCNE2 to inhibit the progression of nonsmall cell lung cancer via the PI3K/AKT pathway	5
Reviewing on AI‐Designed Antibiotic Targeting Drug‐Resistant Superbugs by Emphasizing Mechanisms of Action	5
Drug upgrade: A complete methodology from old drug to new chemical entities using Nematic Protein Organization Technique	5
Lazertinib: A Cardio‐Safer Alternative to Osimertinib for Epidermal Growth Factor Receptor L858R/T790M Double‐Mutant Tyrosine Kinase Resistant Non‐Small Cell Lung Cancer	5
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Anxiolytic Effect of Sesamol, Possibly Through the GABAkine Interaction Pathway	5
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A cytotoxic survey on 2‐amino‐1H‐imidazol based synthetic marine sponge alkaloid analogues	5
Serum Amyloid A1 Mediates Paclitaxel Resistance via MD2‐Dependent Pathways in Triple‐Negative Breast Cancer	5
Novel Benzimidazole‐Pyridine‐Phenylalkanesulfonate Hybrids: Design, Synthesis, Antimicrobial Screening, Lanosterol 14α‐Demethylase Inhibition Properties and in Silico Studies	5
The transcription factor ATF2 promotes gastric cancer progression by activating the METTL3/cyclin D1 pathway	5
SEP‐363856 exerts neuroprotection through the PI3K/AKT/GSK‐3β signaling pathway in a dual‐hit neurodevelopmental model of schizophrenia‐like mice	4
Reprogramming the Tumor Microenvironment: Calebin A as a Polyphenolic Paradigm Shift in Controlling Inflammation, Stemness, and Resistance in Colorectal Cancer	4
Structure‐Guided Optimization and Biological Validation of 1,3,4‐Thiadiazole‐Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions	4
Optimizing Treatment: The Role of Pharmacology, Genomics, and AI in Improving Patient Outcomes	4
Piperidine‐Based Hydrazones and Their Pt(II)/Pd(II) Complexes: Synthesis, Structural Characterization, In Vitro Anticancer Evaluation, and In Silico Studies	4