Journal of Cerebral Blood Flow and Metabolism

Article	Citations
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*	606
Regulation of blood–brain barrier integrity by microglia in health and disease: A therapeutic opportunity	217
Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke	105
Benefits of exercise training on cerebrovascular and cognitive function in ageing	77
MiR-17-92 enriched exosomes derived from multipotent mesenchymal stromal cells enhance axon-myelin remodeling and motor electrophysiological recovery after stroke	63
Tissue no-reflow despite full recanalization following thrombectomy for anterior circulation stroke with proximal occlusion: A clinical study	62
Body mass index, time of day and genetics affect perivascular spaces in the white matter	58
Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvessels	57
Causes and consequences of baseline cerebral blood flow reductions in Alzheimer’s disease	57
Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update	50
Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study	48
Epitranscriptomic regulation by m6A RNA methylation in brain development and diseases	48
Mitochondrial quality control in acute ischemic stroke	48
Neuroinflammatory responses of microglia in central nervous system trauma	41
Three-dimensional ultrastructure of the brain pericyte-endothelial interface	39
Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome	39
Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns	39
Interleukin-4 improves white matter integrity and functional recovery after murine traumatic brain injury via oligodendroglial PPARγ	39
Altered glymphatic enhancement of cerebrospinal fluid tracer in individuals with chronic poor sleep quality	38
Deep white matter hyperintensity is associated with the dilation of perivascular space	38
HDAC inhibition reduces white matter injury after intracerebral hemorrhage	37
Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model	37
Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with 15O PET in healthy adults	37
Regional hyperperfusion in older adults with objectively-defined subtle cognitive decline	36
PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflamm	35

Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective	35
Change and predictive ability of circulating immunoregulatory lymphocytes in long-term outcomes of acute ischemic stroke	34
Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion	34
Impact of sex andAPOEε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study	33
Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET	33
Glymphatic pathways in the gyrencephalic brain	33
Role of perivascular and meningeal macrophages in outcome following experimental subarachnoid hemorrhage	33
Hippocampal blood–brain barrier permeability is related to the APOE4 mutation status of elderly individuals without dementia	32
Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke	31
Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice	31
Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging	29
D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI	28
Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task	28
Cerebrovascular phenotypes in mouse models of Alzheimer’s disease	28
Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview	27
Integrative cerebral blood flow regulation in ischemic stroke	27
Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury	27
Aging related impairment of brain microvascular bioenergetics involves oxidative phosphorylation and glycolytic pathways	26
Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients	26
Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults	26
How expensive is the astrocyte?	26
Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques	26
Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke	25
Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage	25
Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression	25
Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission	25
Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy	25
Microglial phagocytosis and regulatory mechanisms after stroke	25
Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study	24
Aerobic exercise improves hippocampal blood flow for hypertensive Apolipoprotein E4 carriers	24
Profiling cerebrovascular function in migraine: A systematic review and meta-analysis	24
Microvascular changes associated with epilepsy: A narrative review	24
Glucagon-like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review	24
4D flow MRI for non-invasive measurement of blood flow in the brain: A systematic review	24
Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment	24
Functional dynamics of dopamine synthesis during monetary reward and punishment processing	24
Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development	24
Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue	23
Microglia/macrophage polarization: Fantasy or evidence of functional diversity?	23
Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study	22
Choroid plexus function in neurological homeostasis and disorders: The awakening of the circadian clocks and orexins	22
Low neuronal metabolism during isoflurane-induced burst suppression is related to synaptic inhibition while neurovascular coupling and mitochondrial function remain intact	22
Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study	22
Targeting neutrophils as a novel therapeutic strategy after stroke	22
In vivo synaptic density relates to glucose metabolism at rest in healthy subjects, but is strongly modulated by regional differences	22
Connexin43 promotes angiogenesis through activating the HIF-1α/VEGF signaling pathway under chronic cerebral hypoperfusion	22
Linking cortical atrophy to white matter hyperintensities of presumed vascular origin	22
Lenticulostriate artery combined with neuroimaging markers of cerebral small vessel disease differentiate the pathogenesis of recent subcortical infarction	21
Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury	21
Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke	21

A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: From normal physiology to pathophysiological changes	21
Reliability of task-specific neuronal activation assessed with functional PET, ASL and BOLD imaging	21
Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci	20
Review of treatment and therapeutic targets in brain arteriovenous malformation	20
Role of endothelium-pericyte signaling in capillary blood flow response to neuronal activity	20
More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke	20
Oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt/β-catenin pathway in a mouse model of middle cerebral artery occlusion	20
Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction	20
Hypoxemia increases blood-brain barrier permeability during extreme apnea in humans	20
[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain	19
The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders	19
A line through the brain: implementation of human line-scanning at 7T for ultra-high spatiotemporal resolution fMRI	19
Remote ischemic conditioning enhances oxygen supply to ischemic brain tissue in a mouse model of stroke: Role of elevated 2,3-biphosphoglycerate in erythrocytes	19
Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult	19
Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury	19
Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture	19
Effects of increased intracranial pressure on cerebrospinal fluid influx, cerebral vascular hemodynamic indexes, and cerebrospinal fluid lymphatic efflux	19
Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition	19
Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep	19
Effects of O-GlcNAcylation on functional mitochondrial transfer from astrocytes	19
Reliability and validity of the mean flow index (Mx) for assessing cerebral autoregulation in humans: A systematic review of the methodology	19
MRI-visible perivascular spaces in basal ganglia but not centrum semiovale or hippocampus were related to deep medullary veins changes	19
Effect of uric acid in animal models of ischemic stroke: A systematic review and meta-analysis	18
Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics	18
Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease	18
In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease	18
White matter network damage mediates association between cerebrovascular disease and cognition	18
Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib	18
Metabolic underpinnings of activated and deactivated cortical areas in human brain	18
Cerebral blood flow measurements with 15O-water PET using a non-invasive machine-learning-derived arterial input function	18
Cerebral ischemia in the developing brain	18
Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging	17
Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI	17
A novel method of quantifying hemodynamic delays to improve hemodynamic response, and CVR estimates in CO2 challenge fMRI	17
Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice	17
Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences	17
Longitudinal monitoring of microglial/macrophage activation in ischemic rat brain using Iba-1-specific nanoparticle-enhanced magnetic resonance imaging	17
Selective intra-carotid blood cooling in acute ischemic stroke: A safety and feasibility study in an ovine stroke model	17
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke	17
Altered regional cerebral blood flow in obstructive sleep apnea is associated with sleep fragmentation and oxygen desaturation	17
A large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain	17
Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain	17
A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models	17
CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome	16
Inflammation-relevant microbiome signature of the stroke brain, gut, spleen, and thymus and the impact of exercise	16
Longitudinal cortex-wide monitoring of cerebral hemodynamics and oxygen metabolism in awake mice using multi-parametric photoacoustic microscopy	16
Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway	16
Hemispheric CSF volume ratio quantifies progression and severity of cerebral edema after acute hemispheric stroke	16
Assessing cerebral arterial pulse wave velocity using 4D flow MRI	16
Hemodynamic and structural brain measures in high and low sedentary older adults	16
Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans	16
Poor venous outflow profiles increase the risk of reperfusion hemorrhage after endovascular treatment	16
Using arterial spin labeling to measure cerebrovascular reactivity in Moyamoya disease: Insights from simultaneous PET/MRI	16
Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice	15
Accumulation of PSA-NCAM marks nascent neurodegeneration in the dorsal hippocampus after neonatal hypoxic-ischemic brain injury in mice	15
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage	15
CNS-peripheral immune interactions in hemorrhagic stroke	15
Tenascin-C induction exacerbates post-stroke brain damage	15
Systematic review: Association between circulating microRNA expression & stroke	15
Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan	15
A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit	15
Principles and requirements for stroke recovery science	15
Kinetics and 28-day test–retest repeatability and reproducibility of [11C]UCB-J PET brain imaging	15
Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers	15
Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2	15
The impact of native leptomeningeal collateralization on rapid blood flow recruitment following ischemic stroke	15
Intracranial vessel wall lesions on 7T MRI and MRI features of cerebral small vessel disease: The SMART-MR study	15
Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy	15
Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein	15
High-altitude rodents have abundant collaterals that protect against tissue injury after cerebral, coronary and peripheral artery occlusion	14
Cerebral endothelial cell-derived small extracellular vesicles enhance neurovascular function and neurological recovery in rat acute ischemic stroke models of mechanical thrombectomy and embolic strok	14
Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?	14
Integrative analysis of the human brain mural cell transcriptome	14
Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis	14
Role of platelets in the pathogenesis of delayed injury after subarachnoid hemorrhage	14
Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and S-nitrosothiol mediated signal transduction	14
Arterial elasticity, endothelial function and intracranial vascular health: A multimodal MRI study	14
Changes in synaptic density in the subacute phase after ischemic stroke: A11C-UCB-J PET/MR study	14
Brain oxygen extraction fraction mapping in patients with multiple sclerosis	13
Long-term outcome of endovascular therapy for acute basilar artery occlusion	13

Free-water diffusion MRI detects structural alterations surrounding white matter hyperintensities in the early stage of cerebral small vessel disease	13
Impact of blood pressure changes in cerebral blood perfusion of patients with ischemic Moyamoya disease evaluated by SPECT	13
A cluster of blood-based protein biomarkers reflecting coagulation relates to the burden of cerebral small vessel disease	13
Leptomeningeal collateral activation indicates severely impaired cerebrovascular reserve capacity in patients with symptomatic unilateral carotid artery occlusion	13
Impaired damping of cerebral blood flow velocity pulsatility is associated with the number of perivascular spaces as measured with 7T MRI	13
The roles of microglia and astrocytes in myelin phagocytosis in the central nervous system	13
Can oligodendrocyte precursor cells be a therapeutic target for mitigating cognitive decline in cerebrovascular disease?	13
MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice	13
Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease	13
Metabolomic and transcriptional profiling reveals bioenergetic stress and activation of cell death and inflammatory pathways in vivo after neuronal deletion of NAMPT	13
Impact of meningeal uptake and partial volume correction techniques on [18F]MK-6240 binding in aMCI patients and healthy controls	13
Differential contribution of excitatory and inhibitory neurons in shaping neurovascular coupling in different epileptic neural states	13
The rise of pericytes in neurovascular research	13
Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes via α2 adrenergic receptors	13
Cerebral critical closing pressure and resistance-area product: the influence of dynamic cerebral autoregulation, age and sex	13
Deep medullary veins are associated with widespread brain structural abnormalities	12
Phenotypic variability in 446 CADASIL patients: Impact of NOTCH3 gene mutation location in addition to the effects of age, sex and vascular risk factors	12
Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques*	12
Repeated hypoxia exposure induces cognitive dysfunction, brain inflammation, and amyloidβ/p-Tau accumulation through reduced brain O-GlcNAcylation in zebrafish	12
Evaluation of single bolus, dual-echo dynamic susceptibility contrast MRI protocols in brain tumor patients	12
Impaired capillary-to-arteriolar electrical signaling after traumatic brain injury	12
NMDA receptor ion channel activation detected in vivo with [18F]GE-179 PET after electrical stimulation of rat hippocampus	12
Dilated perivascular space is related to reduced free-water in surrounding white matter among healthy adults and elderlies but not in patients with severe cerebral small vessel disease	12
The central role of peripheral inflammation in ischemic stroke	12
Wiring and plumbing: Oligodendrocyte precursors and angiogenesis in the oligovascular niche	12
Increased capillary stalling is associated with endothelial glycocalyx loss in subcortical vascular dementia	12
Protective effects of edaravone on white matter pathology in a novel mouse model of Alzheimer’s disease with chronic cerebral hypoperfusion	12
Choroid plexus perfusion in sickle cell disease and moyamoya vasculopathy: Implications for glymphatic flow	12
A functional cerebral endothelium is necessary to protect against cognitive decline	12
One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults	12