Journal of Cerebral Blood Flow and Metabolism

Article	Citations
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*	542
Regulation of blood–brain barrier integrity by microglia in health and disease: A therapeutic opportunity	197
Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke	89
Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update	86
Benefits of exercise training on cerebrovascular and cognitive function in ageing	71
Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: A hyperacute role for neutrophils in persistent traffic jams	68
Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1	64
Tissue no-reflow despite full recanalization following thrombectomy for anterior circulation stroke with proximal occlusion: A clinical study	61
MiR-17-92 enriched exosomes derived from multipotent mesenchymal stromal cells enhance axon-myelin remodeling and motor electrophysiological recovery after stroke	58
Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvessels	56
Body mass index, time of day and genetics affect perivascular spaces in the white matter	54
Collateral status contributes to differences between observed and predicted 24-h infarct volumes in DEFUSE 3	53
Causes and consequences of baseline cerebral blood flow reductions in Alzheimer’s disease	53
Epitranscriptomic regulation by m6A RNA methylation in brain development and diseases	46
Transcriptomic characterization of microglia activation in a rat model of ischemic stroke	45
Sexual differences in mitochondrial and related proteins in rat cerebral microvessels: A proteomic approach	44
Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study	43
Mitochondrial quality control in acute ischemic stroke	39
Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update	39
Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia	39
Galectin-3 protects against ischemic stroke by promoting neuro-angiogenesis via apoptosis inhibition and Akt/Caspase regulation	37
Neuroinflammatory responses of microglia in central nervous system trauma	37
Interleukin-4 improves white matter integrity and functional recovery after murine traumatic brain injury via oligodendroglial PPARγ	36
Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns	35
HDAC inhibition reduces white matter injury after intracerebral hemorrhage	35

PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflamm	35
Regional hyperperfusion in older adults with objectively-defined subtle cognitive decline	34
Hypoxia induces de novo formation of cerebral collaterals and lessens the severity of ischemic stroke	34
Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with 15O PET in healthy adults	34
Three-dimensional ultrastructure of the brain pericyte-endothelial interface	34
Deep white matter hyperintensity is associated with the dilation of perivascular space	34
Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome	33
Impact of sex andAPOEε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study	33
Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective	32
Change and predictive ability of circulating immunoregulatory lymphocytes in long-term outcomes of acute ischemic stroke	32
Microvascular platelet aggregation and thrombosis after subarachnoid hemorrhage: A review and synthesis	31
Altered glymphatic enhancement of cerebrospinal fluid tracer in individuals with chronic poor sleep quality	31
Altered coupling of cerebral blood flow and functional connectivity strength in visual and higher order cognitive cortices in primary open angle glaucoma	31
Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model	30
Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion	30
Role of perivascular and meningeal macrophages in outcome following experimental subarachnoid hemorrhage	29
Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET	29
Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging	29
Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice	28
Hippocampal blood–brain barrier permeability is related to the APOE4 mutation status of elderly individuals without dementia	27
Glymphatic pathways in the gyrencephalic brain	27
Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke	27
Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task	27
D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI	27
Cerebrovascular phenotypes in mouse models of Alzheimer’s disease	26
Integrative cerebral blood flow regulation in ischemic stroke	26
Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients	25
Simulation of oxygen transport and estimation of tissue perfusion in extensive microvascular networks: Application to cerebral cortex	25
Microbiota in cerebrovascular disease: A key player and future therapeutic target	25
Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults	25
Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy	24
Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview	24
Rbfox-1 contributes to CaMKIIα expression and intracerebral hemorrhage-induced secondary brain injury via blocking micro-RNA-124	24
Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage	24
Glucagon-like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review	24
Profiling cerebrovascular function in migraine: A systematic review and meta-analysis	24
Microvascular changes associated with epilepsy: A narrative review	24
MicroRNA-30a regulates acute cerebral ischemia-induced blood–brain barrier damage through ZnT4/zinc pathway	23
Aerobic exercise improves hippocampal blood flow for hypertensive Apolipoprotein E4 carriers	23
Brain deep medullary veins on 3-T MRI in a population-based cohort	23
Cerebral perfusion and blood–brain barrier assessment in brain trauma using contrast-enhanced near-infrared spectroscopy with indocyanine green: A review	23
Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke	23
Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission	23
How expensive is the astrocyte?	23
Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury	23
Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development	23
Microglia/macrophage polarization: Fantasy or evidence of functional diversity?	22
Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment	22
4D flow MRI for non-invasive measurement of blood flow in the brain: A systematic review	22
Mechanisms of the negative potential associated with Leão’s spreading depolarization: A history of brain electrogenesis	22

Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system	22
Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques	22
In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET	21
Targeting neutrophils as a novel therapeutic strategy after stroke	21
Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study	21
Hemodynamic impairments within individual watershed areas in asymptomatic carotid artery stenosis by multimodal MRI	21
Low neuronal metabolism during isoflurane-induced burst suppression is related to synaptic inhibition while neurovascular coupling and mitochondrial function remain intact	21
Opposed hemodynamic responses following increased excitation and parvalbumin-based inhibition	21
Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression	21
The role of spreading depolarizations and electrographic seizures in early injury progression of the rat photothrombosis stroke model	20
More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke	20
Connexin43 promotes angiogenesis through activating the HIF-1α/VEGF signaling pathway under chronic cerebral hypoperfusion	20
Lenticulostriate artery combined with neuroimaging markers of cerebral small vessel disease differentiate the pathogenesis of recent subcortical infarction	20
Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury	20
Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke	19
Optimized lactoferrin as a highly promising treatment for intracerebral hemorrhage: Pre-clinical experience	19
Reduced oxygen extraction efficiency in sickle cell anemia patients with evidence of cerebral capillary shunting	19
Choroid plexus function in neurological homeostasis and disorders: The awakening of the circadian clocks and orexins	19
Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study	19
Linking cortical atrophy to white matter hyperintensities of presumed vascular origin	19
CD36 deficiency reduces chronic BBB dysfunction and scar formation and improves activity, hedonic and memory deficits in ischemic stroke	19
MRI-visible perivascular spaces in basal ganglia but not centrum semiovale or hippocampus were related to deep medullary veins changes	19
Microglial phagocytosis and regulatory mechanisms after stroke	19
In vivo synaptic density relates to glucose metabolism at rest in healthy subjects, but is strongly modulated by regional differences	19
A line through the brain: implementation of human line-scanning at 7T for ultra-high spatiotemporal resolution fMRI	19
Effects of O-GlcNAcylation on functional mitochondrial transfer from astrocytes	18
Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture	18
Hypoxemia increases blood-brain barrier permeability during extreme apnea in humans	18
Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling	18
Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation	18
Oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt/β-catenin pathway in a mouse model of middle cerebral artery occlusion	18
A meta-analysis of remote ischaemic conditioning in experimental stroke	18
Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue	18
Repetitive mTBI is associated with age-related reductions in cerebral blood flow but not cortical thickness	18
Aging related impairment of brain microvascular bioenergetics involves oxidative phosphorylation and glycolytic pathways	18
Review of treatment and therapeutic targets in brain arteriovenous malformation	18
Role of endothelium-pericyte signaling in capillary blood flow response to neuronal activity	18
[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain	18
Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction	17
Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult	17
The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders	17
Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics	17
Reliability of task-specific neuronal activation assessed with functional PET, ASL and BOLD imaging	17
Reversal of neurovascular coupling in the default mode network: Evidence from hypoxia	17
Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep	17
A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: From normal physiology to pathophysiological changes	16
Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib	16
A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models	16
Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences	16
Functional dynamics of dopamine synthesis during monetary reward and punishment processing	16
Effects of increased intracranial pressure on cerebrospinal fluid influx, cerebral vascular hemodynamic indexes, and cerebrospinal fluid lymphatic efflux	16
Hemodynamic and structural brain measures in high and low sedentary older adults	16
Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition	16
TET3 regulates DNA hydroxymethylation of neuroprotective genes following focal ischemia	16
Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury	16
Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study	16
Remote ischemic conditioning enhances oxygen supply to ischemic brain tissue in a mouse model of stroke: Role of elevated 2,3-biphosphoglycerate in erythrocytes	16
A novel method of quantifying hemodynamic delays to improve hemodynamic response, and CVR estimates in CO2 challenge fMRI	16
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke	16
Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci	16
A non-human primate model of stroke reproducing endovascular thrombectomy and allowing long-term imaging and neurological read-outs	16
Longitudinal monitoring of microglial/macrophage activation in ischemic rat brain using Iba-1-specific nanoparticle-enhanced magnetic resonance imaging	16
Altered regional cerebral blood flow in obstructive sleep apnea is associated with sleep fragmentation and oxygen desaturation	15
Assessing cerebral arterial pulse wave velocity using 4D flow MRI	15
Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI	15
Cerebral perfusion is associated with blast exposure in military personnel without moderate or severe TBI	15
Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease	15
Metabolic underpinnings of activated and deactivated cortical areas in human brain	15
Accumulation of PSA-NCAM marks nascent neurodegeneration in the dorsal hippocampus after neonatal hypoxic-ischemic brain injury in mice	15
Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy	15
CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome	15
Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice	15
Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice	15
Test–retest variability and reference region-based quantification of 18F-BCPP-EF for imaging mitochondrial complex I in the human brain	15
Principles and requirements for stroke recovery science	15
Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain	15
Ischemic lesion water homeostasis after thrombectomy for large vessel occlusion stroke within the anterior circulation: The impact of age	15
Intracranial vessel wall lesions on 7T MRI and MRI features of cerebral small vessel disease: The SMART-MR study	14
White matter network damage mediates association between cerebrovascular disease and cognition	14
Cerebral ischemia in the developing brain	14

Poor venous outflow profiles increase the risk of reperfusion hemorrhage after endovascular treatment	14
Hemispheric CSF volume ratio quantifies progression and severity of cerebral edema after acute hemispheric stroke	14
Using arterial spin labeling to measure cerebrovascular reactivity in Moyamoya disease: Insights from simultaneous PET/MRI	14
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage	14
Cerebral blood flow measurements with 15O-water PET using a non-invasive machine-learning-derived arterial input function	14
Effect of uric acid in animal models of ischemic stroke: A systematic review and meta-analysis	14
Reliability and validity of the mean flow index (Mx) for assessing cerebral autoregulation in humans: A systematic review of the methodology	14
A large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain	14
Arterial elasticity, endothelial function and intracranial vascular health: A multimodal MRI study	14
Kinetics and 28-day test–retest repeatability and reproducibility of [11C]UCB-J PET brain imaging	14
Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans	14
Integrative analysis of the human brain mural cell transcriptome	14
Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis	14
Role of platelets in the pathogenesis of delayed injury after subarachnoid hemorrhage	13
Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2	13
Biomechanics and hemodynamics of stent-retrievers	13
Inflammation-relevant microbiome signature of the stroke brain, gut, spleen, and thymus and the impact of exercise	13
Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers	13
A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit	13
Systematic review: Association between circulating microRNA expression & stroke	13
Selective intra-carotid blood cooling in acute ischemic stroke: A safety and feasibility study in an ovine stroke model	13
Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging	13
Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?	13
Longitudinal cortex-wide monitoring of cerebral hemodynamics and oxygen metabolism in awake mice using multi-parametric photoacoustic microscopy	13
Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein	13
Can oligodendrocyte precursor cells be a therapeutic target for mitigating cognitive decline in cerebrovascular disease?	13
Cerebral haemodynamics with head position changes post-ischemic stroke: A systematic review and meta-analysis	13
Optimized mouse model of embolic MCAO: From cerebral blood flow to neurological outcomes	13
Simultaneous nicotine and oral contraceptive exposure alters brain energy metabolism and exacerbates ischemic stroke injury in female rats	13
Cerebroarterial pulsatility and resistivity indices are associated with cognitive impairment and white matter hyperintensity in elderly subjects: A phase-contrast MRI study	13
High-altitude rodents have abundant collaterals that protect against tissue injury after cerebral, coronary and peripheral artery occlusion	13
Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway	13