Journal of Cerebral Blood Flow and Metabolism

Article	Citations
Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals	123
Microglia: Active participants in brain capillary function	67
Preconditioning with interleukin-1 alpha is required for the neuroprotective properties of mesenchymal stem cells after ischemic stroke in mice	64
Dynamic cerebral autoregulation in people with mild cognitive impairment	62
Association between occlusion location, net water uptake and ischemic lesion growth in large vessel anterior circulation strokes	61
Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke	60
Targeted capillary photothrombosis via multiphoton excitation of Rose Bengal	60
Blood-brain barrier disruption imaging in postoperative cerebral hyperperfusion syndrome using DCE-MRI	53
Resuscitation with epinephrine worsens cerebral capillary no-reflow after experimental pediatric cardiac arrest: An in vivo multiphoton microscopy evaluation	47
Vascular synthesis based on hemodynamic efficiency principle recapitulates measured cerebral circulation properties in the human brain	46
Impact of hypertension on cerebral small vessel disease: A post-mortem study of microvascular pathology from normal-appearing white matter into white matter hyperintensities	46
CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation	45
Post-stroke brain can be protected by modulating the lncRNA FosDT	45
Critical role of Slc22a8 in maintaining blood-brain barrier integrity after experimental cerebral ischemia-reperfusion	44
Sigma-1 receptor signaling: A potential therapeutic approach for ischemic stroke	44
Vessel architecture imaging reveals microvascular rarefaction and capillary-to-arteriole shift in cerebral small vessel disease	44
A cluster of blood-based protein biomarkers reflecting coagulation relates to the burden of cerebral small vessel disease	43
Post cardiac arrest physical exercise mitigates cell death in the septal and thalamic nuclei and ameliorates contextual fear conditioning deficits in rats	41
Dynamic neuroreceptor positron emission tomography in non-anesthetized rats using point source based motion correction: A feasibility study with [11C]ABP688	40
Nogo-A is secreted in extracellular vesicles, occurs in blood and can influence vascular permeability	39
Brain & Brain pet 2025 Abstracts	38
Baseline CBV-normalized BOLD fMRI of visual stimulation in awake vs. anesthetized mice	36
The effect of hypercapnia on the directional sensitivity of dynamic cerebral autoregulation and the influence of age and sex	36
Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition	36
Amyloid beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-AKT pathway	35

Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review	35
Phenotypic variability in 446 CADASIL patients: Impact of NOTCH3 gene mutation location in addition to the effects of age, sex and vascular risk factors	34
Pathological changes of brain oscillations following ischemic stroke	34
RNF213 variant and autophagic impairment: A pivotal link to endothelial dysfunction in moyamoya disease	33
Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease	33
Predicting cerebral infarction in patients with atrial fibrillation using machine learning: The Fushimi AF registry	32
Microglial phagocytosis and regulatory mechanisms after stroke	32
Plasminogen activator inhibitor-1 mediates cerebral ischemia-induced astrocytic reactivity	31
NK1 tachykinin receptor antagonist treatment reduces cerebral edema and intracranial pressure in an ovine model of ischemic stroke	31
Association of cognitive function and hypoperfusion in Moyamoya disease patients without stroke	31
Temperature dysregulation during therapeutic hypothermia predicts long-term outcome in neonates with HIE	31
Effect of vascular amyloid on white matter disease is mediated by vascular dysfunction in cerebral amyloid angiopathy	31
Elucidating stroke etiology through lipidomics of thrombi and plasma in acute ischemic stroke patients undergoing endovascular thrombectomy	31
Role of pterygopalatine ganglion in regulating isoflurane-induced cerebral hyper-perfusion	30
Inactivation of BACE1 increases expression of endothelial nitric oxide synthase in cerebrovascular endothelium	30
Co-transplantation of autologous treg cells: A groundbreaking cell therapy for brain diseases	30
Characteristics of activation of monocyte-derived macrophages versus microglia after mouse experimental intracerebral hemorrhage	29
Characterizing pre- and post-operative cerebral blood flow and transit time in pediatric moyamoya patients using multi-delay ASL and DSC MRI	28
Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke	28
Reversible edema after radiosurgery for arteriovenous malformations (AVMs): Inflow and outflow imbalance	28
Cerebrovascular morphology: Insights into normal variations, aging effects and disease implications	28
Endothelial progenitor cell transplantation attenuates synaptic loss associated with enhancing complement receptor 3-dependent microglial/macrophage phagocytosis in ischemic mice	27
Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence	27
Magnetic resonance imaging indices for early Alzheimer’s disease detection: Brain clearance markers	25
Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis	25
Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation	25
Incidence, severity and impact on functional outcome of persistent hypoperfusion despite large-vessel recanalization, a potential marker of impaired microvascular reperfusion: Systematic review of the	24
Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics	24
Non-invasive [ 15 O]H 2 O PET measurements of cerebral perfusion and cerebrovascular reactivity using an additional heart scan	23
A systematic review and in silico analysis of studies investigating the ischemic penumbra proteome in animal models of experimental stroke	23
Reliable infarction of the middle cerebral artery territory in C57BL/6 mice using pterygopalatine artery ligation and filament optimization – The PURE-MCAo model	23
Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI	23
Cerebral multi-autoregulation model based enhanced external counterpulsation treatment planning for cerebral ischemic stroke	22
Cerebral O2 and CO2 transport in isovolumic haemodilution: Compensation of cerebral delivery of O2 and maintenance of cerebrovascular reactivity to CO2	22
Capillaries susceptible to frequent stall dynamics revealed by comparing OCT and bessel-2PM measurements	22
Statistical non-independence of brain metabolite concentrations whether normalized to creatine or water	22
Genetics of intracerebral hemorrhage	22
Association between time-dependent changes in cerebrovascular autoregulation after cardiac arrest and outcomes: A prospective cohort study	22
Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and S-nitrosothiol mediated signal transduction	21
Measuring capillary flow dynamics using interlaced two-photon volumetric scanning	21
Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study	21
Multimodal and serial MRI monitors brain peri-hematomal injury and repair mechanisms after experimental intracerebral hemorrhage	21
Targeting seryl-tRNA synthetase to unlock ischemic resilience in stroke – Insights from a proof-of-concept study	21
Transcriptome analyses of brain arteries and microvessels in male and female mice reveal prominent olfactory receptor gene and protein expression	21
Corrigendum	20
A new framework for metabolic connectivity mapping using bolus [ 18 F]FDG PET and kinetic modeling	20
Increased peripheral leukocyte aggravates brain injury and leads to poor outcome in stroke patients receiving intravenous thrombolysis: A study based on clinical evidence	20
Brain water dynamics across sleep stages measured by near-infrared spectroscopy: Implications for glymphatic function	20
Quantitation of regional distribution of antibodies in rat brain following systemic and intra-CNS administration	20
Impact of meningeal uptake and partial volume correction techniques on [18F]MK-6240 binding in aMCI patients and healthy controls	20

A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMRO2) with single gas calibrated fMRI	20
Thanks to Reviewers	20
Hyperoxia evokes pericyte-mediated capillary constriction	20
Characterizing the protective vasodilatory effects of hypobaric hypoxia on the neurovascular coupling response	20
Micro-ultrasound based characterization of cerebrovasculature following focal ischemic stroke and upon short-term rehabilitation	19
Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population	19
Sex modifies the relationship between age and neurovascular coupling in healthy adults	19
Predictive value of cerebrovascular time constant for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage	19
Rapid, selective and homogeneous brain cooling with transnasal flow of ambient air for pediatric resuscitation	19
Preliminary investigations into human neurofluid transport using multiple novel non-contrast MRI methods	19
Impaired dynamic cerebral autoregulation predicts silent ischemic lesions after carotid artery stenting: A hemodynamic biomarker beyond plaque morphology	19
Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury	19
Spatiotemporal analysis of blood plasma and blood cell flow fluctuations of cerebral microcirculation in anesthetized rats	19
Two possible hemodynamic mechanisms underlying the growth of cerebral aneurysms depending on their size: The NHO CFD ABO study	18
A lone spike in blood glucose can enhance the thrombo-inflammatory response in cortical venules	18
Treatment with apocynin selectively restores hippocampal arteriole function and seizure-induced hyperemia in a model of preeclampsia	18
Mild hypercapnia before reperfusion reduces ischemia-reperfusion injury in hyperacute ischemic stroke rat model	18
MRI evaluation of cerebral metabolic rate of oxygen (CMRO2) in obstructive sleep apnea	18
High-resolution vasomotion analysis reveals novel arteriole physiological features and progressive modulation of cerebral vascular networks by stroke	18
Targeted proteomic analysis identifies ACVRL1 as a marker of cerebral edema in aneurysmal subarachnoid hemorrhage	18
Multifaceted neural and vascular pathologies after pediatric mild traumatic brain injury	18
Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan	18
Quantification of the purinergic P2X7 receptor with [11C]SMW139 improves through correction for brain-penetrating radiometabolites	18
The age-associated decline in neuroplasticity and its implications for post-stroke recovery in animal models of cerebral ischemia: The therapeutic role of extracellular vesicles	18
Type 2 diabetes abates retrograde collateral flow and promotes leukocyte adhesion following ischemic stroke	17
Assessing the effects of aging on the Koizumi’s and Zea Longa’s methods and their suitability as mouse models for evaluating neurodegeneration post-ischemic stroke: A comparative study	17
Extracellular vesicles lay the ground for neuronal plasticity by restoring mitochondrial function, cell metabolism and immune balance	17
Post-mortem correlates of Virchow-Robin spaces detected on in vivo MRI	17
Associations of life-course cardiovascular risk factors with late-life cerebral hemodynamics	17
Metabolic implications of axonal demyelination and its consequences for synchronized network activity: An in silico and in vitro study	17
Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia	17
Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders	17
Prophylactic PDE4 and PDE4B inhibition reduce lesion size and neutrophil infiltration following ischemic stroke in male mice	17
Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan	17
Neurovascular coupling in early stage dementia – A case-control study	17
Kinetic modeling of the monoamine oxidase-B radioligand [18F]SMBT-1 in human brain with positron emission tomography	17
Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke	17
A novel model to quantify blood transit time in cerebral arteries using ASL-based 4D magnetic resonance angiography with example clinical application in moyamoya disease	16
Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications	16
Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI	16
Cerebral arterial stiffness is linked to white matter hyperintensities and perivascular spaces in older adults – A 4D flow MRI study	16
Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease	16
Antihypertensives in dementia: Good or bad for the brain?	16
In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging	16
β -hydroxybutyrate enhances brain metabolism in normoglycemia and hyperglycemia, providing cerebroprotection in a mouse stroke model	16
Commentary to Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke	16
Zfp580 inactivation as a new therapeutic target to enhance recovery after stroke in mice	15
Non-classical monocytes promote neurovascular repair in cerebral small vessel disease associated with microinfarctions via CX3CR1	15
Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice	15
Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue	15
Microglial histone deacetylase 2 is dispensable for functional and histological outcomes in a mouse model of traumatic brain injury	15
Control of neurovascular coupling by ATP-sensitive potassium channels	15
Reversal of the detrimental effects of social isolation on ischemic cerebral injury and stroke-associated pneumonia by inhibiting small intestinal γδ T-cell migration into the brain and lung	15
Using human genomics to validate drug targets for acute ischemic stroke	15
Global, regional and national burden of ischemic stroke attributed to high low-density lipoprotein cholesterol, 1990–2019：A decomposition analysis and age-period-cohort analysis	15
Effect of the duration of hypertension on white matter structure and its link with cognition	15
H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1	15
A dangerous liaison: Spreading depolarization and tissue acidification in cerebral ischemia	15
Treatment for moyamoya disease with hyperhomocysteinemia	14
A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase	14
The relationship between cytochrome c oxidase, CBF and CMRO2 in mouse cortex: A NIRS-MRI study	14
Brain-targeted mild hypothermia ameliorates ischemic brain injury and promotes stroke recovery in aged mice	14
Point-Counterpoint: Cerebral perfusion pressure is a high-risk concept	14
Neural and vascular contributions to sensory impairments in a human alpha-synuclein transgenic mouse model of Parkinson’s disease	13
Leukocyte indicators and variations predict worse outcomes after intravenous thrombolysis in patients with acute ischemic stroke	13
High-physiological and supra-physiological 1,2-13C2 glucose focal supplementation to the traumatised human brain	13
A systematic observation of vasodynamics from different segments along the cerebral vasculature in the penumbra zone of awake mice following cerebral ischemia and recanalization	13
“No-reflow” phenomenon in acute ischemic stroke	13
The miR-451a facilitates natural killer cell-associated immune deficiency after ischemic stroke	13
Targeting angiogenesis and white matter repair for enhanced functional recovery after acute ischemic stroke: A focus on the roles of glial cells	13
High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states	13
Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review	13
Correcting SUVR bias by accounting for radiotracer clearance in tissue: A validation study with [ 18 F]FE-PE2I PET in cross-sectional,	13
Systematic review and meta-analysis of transcranial doppler biomarkers for the prediction of delayed cerebral ischemia following subarachnoid hemorrhage	13
Predicting brain temperature in humans using bioheat models: Progress and outlook	13
Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain	13
Cerebral ischemia in the developing brain	12
Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia	12
Accurate and fully automated diameter measurements of Circle of Willis arteries on MRA imaging	12
Acute psilocybin and ketanserin effects on cerebral blood flow: 5-HT2AR neuromodulation in healthy humans	12

Diesel exhaust particles exposure exacerbates pro-thrombogenic plasma features ex-vivo after cerebral ischemia and accelerates tPA-induced clot-lysis in hypertensive subjects	12
Alpha-adrenergic receptor activation after fetal hypoxia-ischaemia suppresses transient epileptiform activity and limits loss of oligodendrocytes and hippocampal neurons	12
Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change	12
Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study	12
Vascular topology and blood flow are acutely impacted by experimental febrile status epilepticus	12
Insulin-stimulated brain glucose uptake correlates with brain metabolites in severe obesity: A combined neuroimaging study	12
A plasma lipid signature in acute human traumatic brain injury: Link with neuronal injury and inflammation markers	12
Metformin attenuates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion	11
Antihypertensives in dementia: Good or bad for the brain?	11
Type-1-to-type-2 transition of brain microvascular pericytes induced by cytokines and disease-associated proteins: Role in neuroinflammation and blood-brain barrier disruption	11
Pretreatment with oleuropein protects the neonatal brain from hypoxia-ischemia by inhibiting apoptosis and neuroinflammation	11
Comparison of approaches for surface vessel diameter and pulsatility quantification	11
Neutrophil-derived cathelicidin promotes cerebral angiogenesis after ischemic stroke	11
Growth arrest specific protein 6 alleviated white matter injury after experimental ischemic stroke	11
Isoform-selective and non-selective rho-kinase inhibitors do not affect collagenase-induced intracerebral hemorrhage outcomes in mice: Influence of sex and circadian cycle	11
Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury	11
Retinal microvascular phenotypes can track small vessel disease burden and CPAP treatment effectiveness in obstructive sleep apnea	11
Superior sagittal sinus flow as a proxy for tracking global cerebral blood flow dynamics during wakefulness and sleep	11
DPSCs-Exos promote OPCs differentiation and white matter repair via Myl9-mediated PRMT5 nucleation after ischemic stroke	11
Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal	11
Choroid plexus function in neurological homeostasis and disorders: The awakening of the circadian clocks and orexins	11
Red blood cells as glucose carriers to the human brain: Modulation of cerebral activity by erythrocyte exchange transfusion in Glut1 deficiency (G1D)	11
Role of miRNAs in neurovascular injury and repair	11
Modification of cerebrovascular morphologies during different stages of life	11
An automatic analysis framework for FDOPA PET neuroimaging	11
Global changes in diffusion tensor imaging during acute ischemic stroke and post-stroke cognitive performance	11
Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update	10
Decreased rates of cerebral protein synthesis in conscious young adults with fragile X syndrome demonstrated by L-[1-11C]leucine PET	10
A systematic review, meta-analysis and meta-regression amalgamating the driven approaches used to quantify dynamic cerebral autoregulation	10
Optimal filtering strategies for task-specific functional PET imaging	10
Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment	10
Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke	10
Contributions of synaptic glutamate versus neuronal spiking activity to cerebral vascular responses in awake mice	10
Striatal dopamine transporter and receptor availability correlate with relative cerebral blood flow measured with [11C]PE2I, [18F]FE-PE2I and [11C]raclopride PET in he	10
Age-related decline in cerebral oxygen consumption in multiple sclerosis	10
Neurovascular coupling assessment by transcranial doppler in acute stroke could be informative of long-term cognitive status	10
A unified approach for identifying PET-based neuronal activation and molecular connectivity with the functional PET toolbox	10
Static and dynamic BOLD fMRI components along white matter fibre tracts and their dependence on the orientation of the local diffusion tensor axis relative to the B0-field	10
Associations between admission levels of multiple biomarkers and subsequent worse outcomes in acute ischemic stroke patients	10
Oxygen extraction efficiency and white matter lesion burden in older adults exhibiting radiological evidence of capillary shunting	10
Preclinical PET imaging of the developing fetus during pregnancy: Current state and future potential	10
Imaging the 5-HT2C receptor with PET: Evaluation of 5-HT2C and 5-HT2A affinity of pimavanserin in the primate brain	10
Fecal microbiota transplantation fails to impart the benefits of circadian-dependent intermittent fasting following ischemic stroke	10
Cannabinoid 1 receptor occupancy and neurovascular responses induced by agonist, antagonist/inverse-agonist, and potential modulator in non-human primate brains: PET/fMRI study	10
Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer’s disease	10
TSPO deficiency exacerbates acute brain damage after intracerebral hemorrhage in male mice	10
Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke	10
Perfusion imaging by arterial spin labeling in migraine: A literature review	10
Molecular heterogeneity in human stroke – What can we learn from the peripheral blood transcriptome?	10