Journal of Cerebral Blood Flow and Metabolism

Article	Citations
Endothelial lincRNA-p21 alleviates cerebral ischemia/reperfusion injury by maintaining blood-brain barrier integrity	141
Long lasting argon neuroprotection in a non-human primate model of transient endovascular ischemic stroke	75
Oxidative stress and chronic cerebral hypoperfusion: An overview from preclinical rodent models	72
Crossed cerebellar diaschisis on 18F-FDG PET: Frequency across neurodegenerative syndromes and association with 11C-PIB and 18F-Flortaucipir	58
Targeting Pdzrn3 maintains adult blood-brain barrier and central nervous system homeostasis	57
Control of neurovascular coupling by ATP-sensitive potassium channels	49
Effect of the duration of hypertension on white matter structure and its link with cognition	46
Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [18F]T-401 and PET	45
Targeted capillary photothrombosis via multiphoton excitation of Rose Bengal	45
Thanks to Reviewers	43
[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain	42
Dysmaturation of sleep state and electroencephalographic activity after hypoxia-ischaemia in preterm fetal sheep	41
Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study	40
Neural cortical organoids from self-assembling human iPSC as a model to investigate neurotoxicity in brain ischemia	38
CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation	38
Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons	37
Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep	36
Microglia balances hypermyelination and demyelination in the brain	35
Nicotinamide phosphoribosyltransferase inhibitor ameliorates mouse aging-induced cognitive impairment	35
Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease	35
Association between the time of day at stroke onset and functional outcome of acute ischemic stroke patients treated with endovascular therapy	34
The relative associations of aortic and carotid artery stiffness with CeVD and cognition	34
Non-classical monocytes promote neurovascular repair in cerebral small vessel disease associated with microinfarctions via CX3CR1	34
Agomelatine promotes differentiation of oligodendrocyte precursor cells and preserves white matter integrity after cerebral ischemic stroke	34
Inhibition of EphA4 reduces vasogenic edema after experimental stroke in mice by protecting the blood-brain barrier integrity	33

Evidence for the beneficial effect of ketamine in the treatment of patients with post-traumatic stress disorder: A systematic review and meta-analysis	33
Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice	33
Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain	33
The negative effect of aging on cerebral venous outflow in acute ischemic stroke	33
Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice	32
Not open and shut: Complex and prolonged blood-brain barrier responses after stroke	32
Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission	31
Proteomic analysis of jugular venous blood in acute large vessel occlusion stroke with futile recanalization	29
Vascular synthesis based on hemodynamic efficiency principle recapitulates measured cerebral circulation properties in the human brain	29
Alterations of the blood-brain barrier during aging	28
Cohort study on the differential expression of inflammatory and angiogenic factors in thrombi, cerebral and peripheral plasma following acute large vessel occlusion stroke	28
Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue	28
H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1	28
Activin A alleviates neuronal injury through inhibiting cGAS-STING-mediated autophagy in mice with ischemic stroke	27
The cholinergic system modulates negative BOLD responses in the prefrontal cortex once electrical perforant pathway stimulation triggers neuronal afterdischarges in the hippocampus	27
Tenascin-C induction exacerbates post-stroke brain damage	27
Amphetamine-induced dopamine release in rat: Whole-brain spatiotemporal analysis with [11C]raclopride and positron emission tomography	26
Global, regional and national burden of ischemic stroke attributed to high low-density lipoprotein cholesterol, 1990–2019：A decomposition analysis and age-period-cohort analysis	26
Reversal of the detrimental effects of social isolation on ischemic cerebral injury and stroke-associated pneumonia by inhibiting small intestinal γδ T-cell migration into the brain and lung	26
A cluster of blood-based protein biomarkers reflecting coagulation relates to the burden of cerebral small vessel disease	26
Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer’s disease therapeutic	26
Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity	25
Unraveling diurnal and technical variability in cerebral hemodynamics from neurovascular 4D-Flow MRI	25
Amyloid-β disrupts unitary calcium entry through endothelial NMDA receptors in mouse cerebral arteries	25
Randomized placebo-controlled trial of CL2020, an allogenic muse cell–based product, in subacute ischemic stroke	25
Imaging quantitative changes in blood-brain barrier permeability using [18F]2-fluoro-2-deoxy-sorbitol ([18F]FDS) PET in relation to glial cell recruitment in a mouse model of end	24
CO2 cerebrovascular reactivity measured with CBF-MRI in older individuals: Association with cognition, physical function, amyloid and tau proteins	24
Early stopping in clinical PET studies: How to reduce expense and exposure	24
Dynamic reorganization of cortical structure in multi-domain regions after capsular and pontine stroke	24
Intraoperative evaluation of local cerebral hemodynamic change by laser speckle contrast imaging for predicting postoperative cerebral hyperperfusion during STA-MCA bypass in adult patients with moyam	23
SIRT1 mediates hypoxic postconditioning- and resveratrol-induced protection against functional connectivity deficits after subarachnoid hemorrhage	23
A dangerous liaison: Spreading depolarization and tissue acidification in cerebral ischemia	23
Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease	23
Anesthetics in pathological cerebrovascular conditions	23
Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult	23
Vascular contributions to cognitive decline: Beyond amyloid and tau in the Harvard Aging Brain Study	23
Rethinking animal attrition in preclinical research: Expressing causal mechanisms of selection bias using directed acyclic graphs	23
Hyperperfusion profiles after recanalization differentially associate with outcomes in a rat ischemic stroke model	23
Dialysis adequacy and hemoglobin levels predict cerebral atrophy in maintenance-hemodialysis patients	23
Static autoregulation in humans	23
Resuscitation with epinephrine worsens cerebral capillary no-reflow after experimental pediatric cardiac arrest: An in vivo multiphoton microscopy evaluation	22
Point/counterpoint: We should not take the direction of blood pressure change into consideration for dynamic cerebral autoregulation quantification	22
Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation	22
The many layers of BOLD. The effect of hypercapnic and hyperoxic stimuli on macro- and micro-vascular compartments quantified by CVR, M, and CBV across cortical depth	22
RETRACTION NOTICE: Vagus nerve mediates the protective effects of melanocortins against cerebral and systemic damage after ischemic stroke	22
Defining cerebral leukocyte populations in local ischemic blood samples from patients with hyperacute stroke	22
Altered resting-state cerebral blood flow and functional connectivity mediate suicidal ideation in major depressive disorder	21
Hemispheric cerebral blood flow predicts outcome in acute small subcortical infarcts	21
Cerebral critical closing pressure and resistance-area product: the influence of dynamic cerebral autoregulation, age and sex	21
Critical role of Slc22a8 in maintaining blood-brain barrier integrity after experimental cerebral ischemia-reperfusion	21

Review of major trials of acute blood pressure management in stroke	21
Brain PET imaging using 11C-flumazenil and 11C-buprenorphine does not support the hypothesis of a mutual interaction between buprenorphine and benzodiazepines at the neurorecepto	21
Post-stroke brain can be protected by modulating the lncRNA FosDT	21
Microglia: Active participants in brain capillary function	20
Reduction of neuroinflammation alleviated mouse post bone fracture and stroke memory dysfunction	20
Capillary responses to functional and pathological activations rely on the capillary states at rest	20
The brain’s “dark energy” puzzle: How strongly is glucose metabolism linked to resting-state brain activity?	20
Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals	20
Commentary to Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke	20
Capillary transit time heterogeneity inhibits cerebral oxygen metabolism in patients with reduced cerebrovascular reserve capacity from steno-occlusive disease	20
Altered hemodynamics and vascular reactivity in a mouse model with severe pericyte deficiency	20
Dynamic cerebral autoregulation measured by diffuse correlation spectroscopy	19
Association between occlusion location, net water uptake and ischemic lesion growth in large vessel anterior circulation strokes	19
Microvascular changes associated with epilepsy: A narrative review	19
Depression, stress and regional cerebral blood flow	19
Blood-brain barrier disruption imaging in postoperative cerebral hyperperfusion syndrome using DCE-MRI	19
Point-Counterpoint: Transfer function analysis of dynamic cerebral autoregulation: To band or not to band?	19
Molecular mechanism of cerebral edema improvement via IL-1RA released from the stroke-unaffected hindlimb by treadmill exercise after cerebral infarction in rats	19
Hemodynamic imaging parameters in brain metastases patients – Agreement between multi-delay ASL and hypercapnic BOLD	18
Zfp580 inactivation as a new therapeutic target to enhance recovery after stroke in mice	18
Preserving stroke penumbra by targeting lipid signalling	18
Microglial histone deacetylase 2 is dispensable for functional and histological outcomes in a mouse model of traumatic brain injury	18
Antihypertensives in dementia: Good or bad for the brain?	18
Physiological variables in association with spreading depolarizations in the late phase of ischemic stroke	18
Profound changes in cerebrospinal fluid proteome and metabolic profile are associated with congenital hydrocephalus	18
Association between electroencephalogram alpha-band oscillations and executive and processing functions in patients with cerebral small vessel diseases	18
Preconditioning with interleukin-1 alpha is required for the neuroprotective properties of mesenchymal stem cells after ischemic stroke in mice	18
Evaluating infusion methods and simplified quantification of synaptic density in vivo with [11C]UCB-J and [18F]SynVesT-1 PET	18
Brain-derived programmed death-ligand 1 mediates immunosuppression post intracerebral hemorrhage	18
Nox2 underpins microvascular inflammation and vascular contributions to cognitive decline	18
Hemorrhagic stroke-induced subtype of inflammatory reactive astrocytes disrupts blood-brain barrier	18
Imaging features of adult moyamoya disease patients with anterior intracerebral hemorrhage based on high-resolution magnetic resonance imaging	17
Association of autosomal dominant polycystic kidney disease with cerebral small vessel disease	17
An update on stem cell therapy for stroke patients: Where are we now?	17
Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS	17
Sigma-1 receptor signaling: A potential therapeutic approach for ischemic stroke	17
Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein	16
Cortical spreading depolarization-induced constriction of penetrating arteries can cause watershed ischemia: A potential mechanism for white matter lesions	16
Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf	16
[11C]PBR28 radiotracer kinetics are not driven by alterations in cerebral blood flow	16
The lateral entorhinal cortex is a hub for local and global dysfunction in early Alzheimer’s disease states	16
NAD+ precursor nutritional supplements sensitize the brain to future ischemic events	16
No-reflow after recanalization in ischemic stroke: From pathomechanisms to therapeutic strategies	16
Reliability of task-specific neuronal activation assessed with functional PET, ASL and BOLD imaging	16
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke	16
Reduced coupling of global brain function and cerebrospinal fluid dynamics in Parkinson’s disease	16
Epigenetic mechanisms and potential therapeutic targets in stroke	16
Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage	16
Data-based modeling of cerebral hemodynamics quantifies impairment of cerebral blood flow regulation in type-2 diabetes	16
Machine learning based analysis of stroke lesions on mouse tissue sections	16
Sporadic cerebral small vessel disease and cognitive decline in healthy older adults: A systematic review and meta-analysis	15
Changes in synaptic density in the subacute phase after ischemic stroke: A 11C-UCB-J PET/MR study	15
Telmisartan prevents high-fat diet-induced neurovascular impairments and reduces anxiety-like behavior	15
Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography	15
Hemodynamic responses in the rat hippocampus are simultaneously controlled by at least two independently acting neurovascular coupling mechanisms	15
Serotonergic regulation of cortical neurovascular coupling and hemodynamics upon awakening from sleep in mice	15
Plasminogen activator inhibitor-1 mediates cerebral ischemia-induced astrocytic reactivity	14
Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvessels	14
Cerebral ischemia in the developing brain	14
Commentary to “Lower middle cerebral artery blood velocity during low-volume high-intensity interval exercise in chronic stroke”	14
Differential vulnerability among cell types in the neurovascular unit: Description and mechanisms	14
Low neuronal metabolism during isoflurane-induced burst suppression is related to synaptic inhibition while neurovascular coupling and mitochondrial function remain intact	14
Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet)	14
Oral Abstracts	14
Novel voxelwise residual analysis of [11C]raclopride PET data improves detection of low-amplitude dopamine release	14
Preclinical validation and kinetic modelling of the SV2A PET ligand [18F]UCB-J in mice	14
Arterial specification precedes microvascular restitution in the peri-infarct cortex that is driven by small microvessels	14
Cerebral hemodynamics and stroke risks in symptomatic intracranial atherosclerotic stenosis with internal versus cortical borderzone infarcts: A computational fluid dynamics study	14
Impaired neuronal integrity in traumatic brain injury detected by 123I-iomazenil single photon emission computed tomography and MRI	13
Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?	13
Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients	13
Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study	13
Putative neurochemical and cell type contributions to hemodynamic activity in the rodent caudate putamen	13
Multi-layered adaptive neoangiogenesis Intra-Operative quantification (MANIOQ)	13
Aeromedical evacuation-relevant hypobaria following traumatic brain injury in rats contributes to cerebral blood flow depression, altered neurochemistry, and increased neuroinflammation	13
Expansion of plasma MicroRNAs over the first month following human stroke	13
Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review	13
Tissue-type plasminogen activator induces TNF-α-mediated preconditioning of the blood-brain barrier	13
Long-term isoflurane anesthesia induces cognitive deficits via AQP4 depolarization mediated blunted glymphatic inflammatory proteins clearance	13
Microglial phagocytosis and regulatory mechanisms after stroke	13

Cerebral blood flow and cerebrovascular resistance across the adult lifespan: A multimodality approach	12
Association between susceptibility value and cerebral blood flow in the bilateral putamen in patients undergoing hemodialysis	12
Metabolite transport across central nervous system barriers	12
Vitamin D deficiency promotes intracranial aneurysm rupture	12
High-physiological and supra-physiological 1,2-13C2 glucose focal supplementation to the traumatised human brain	12
The effectiveness and safety of human urinary kallidinogenase in acute ischemic stroke patients undergoing endovascular therapy	12
Blood-brain barrier breakdown is linked to tau pathology and neuronal injury in a differential manner according to amyloid deposition	12
Mitochondrial quality control in acute ischemic stroke	12
Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease	12
Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion	12
Dynamics of cerebral blood volume during and after middle cerebral artery occlusion in rats – Comparison between ultrafast ultrasound and dynamic susceptibility contrast-enhanced MRI measurements	12
Effect of drug interventions on cerebral hemodynamics in ischemic stroke patients	12
Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition	12
The effect of hypercapnia on the directional sensitivity of dynamic cerebral autoregulation and the influence of age and sex	12
Isoflurane and ketamine-xylazine modify pharmacokinetics of [18F]SynVesT-1 in the mouse brain	12
Point-Counterpoint: Cerebral perfusion pressure is a high-risk concept	12
Effect of vascular amyloid on white matter disease is mediated by vascular dysfunction in cerebral amyloid angiopathy	12
Medin, a link between vascular pathology and dementia?	12
Manipulation of iron status on cerebral blood flow at high altitude in lowlanders and adapted highlanders	12
Depression of dynamic cerebral autoregulation during neural activation: The role of responders and non-responders	12
The relationship between cytochrome c oxidase, CBF and CMRO2 in mouse cortex: A NIRS-MRI study	12
Reproducibility of findings in modern PET neuroimaging: insight from the NRM2018 grand challenge	12
Phenotypic variability in 446 CADASIL patients: Impact of NOTCH3 gene mutation location in addition to the effects of age, sex and vascular risk factors	11
“No-reflow” phenomenon in acute ischemic stroke	11
Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review	11
Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke	11
Extremely low frequency electromagnetic stimulation reduces ischemic stroke volume by improving cerebral collateral blood flow	11
How can integrative physiology advance stroke research and stroke care?	11
Author Index	11
Non-human primate models of focal cortical ischemia for neuronal replacement therapy	11
Association of cognitive function and hypoperfusion in Moyamoya disease patients without stroke	11
Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke	11
Assessment of motion and model bias on the detection of dopamine response to behavioral challenge	11
Post cardiac arrest physical exercise mitigates cell death in the septal and thalamic nuclei and ameliorates contextual fear conditioning deficits in rats	11
Functional magnetic resonance imaging signal has sub-second temporal accuracy	11
Prolonged release of VEGF and Ang1 from intralesionally implanted hydrogel promotes perilesional vascularization and functional recovery after experimental ischemic stroke	11
Duration of spreading depression is the electrophysiological correlate of infarct growth in malignant hemispheric stroke	11
Therapeutic effect of α7 nicotinic receptor activation after ischemic stroke in rats	11
Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature	11
Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment	11