Journal of Cerebral Blood Flow and Metabolism

Article	Citations
Microglia: Active participants in brain capillary function	159
Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals	93
Metabolic profiling and biomarker identification in idiopathic intracranial hypertension with venous sinus stenosis	75
Vessel architecture imaging reveals microvascular rarefaction and capillary-to-arteriole shift in cerebral small vessel disease	70
Non-invasive modelling and parametric methods for quantification of MAO-B activity using [ 11 C]L-deprenyl-D2 PET	65
Stroke-induced gut microbiome dysbiosis accelerates Alzheimer’s disease progression	63
Preconditioning with interleukin-1 alpha is required for the neuroprotective properties of mesenchymal stem cells after ischemic stroke in mice	59
Association between occlusion location, net water uptake and ischemic lesion growth in large vessel anterior circulation strokes	58
Sigma-1 receptor signaling: A potential therapeutic approach for ischemic stroke	57
Vascular synthesis based on hemodynamic efficiency principle recapitulates measured cerebral circulation properties in the human brain	56
Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke	56
Dynamic cerebral autoregulation in people with mild cognitive impairment	53
RETRACTED: CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation	53
Targeting senescence mitigates the deleterious effects of midlife obesity on neurovascular function by partially restoring blood–brain barrier integrity and neurovascular coupling	49
Post-stroke brain can be protected by modulating the lncRNA FosDT	45
Blood-brain barrier disruption imaging in postoperative cerebral hyperperfusion syndrome using DCE-MRI	44
Impact of hypertension on cerebral small vessel disease: A post-mortem study of microvascular pathology from normal-appearing white matter into white matter hyperintensities	42
SPI1 promotes endothelial cell ferroptosis and intracranial aneurysm progression via EP300-mediated FOSL2 acetylation	42
Targeted capillary photothrombosis via multiphoton excitation of Rose Bengal	41
Spreading depolarization: A wave that precedes and drives cerebral ischemic cell death—Target for neuroprotection	40
Quantitative susceptibility mapping of the brain is associated with inflammatory changes in Alzheimer’s disease related areas	40
The role and mechanism of lysyl hydroxylase 1 (LH1) in vascular lesions in hypertensive intracerebral hemorrhage	38
Critical role of Slc22a8 in maintaining blood-brain barrier integrity after experimental cerebral ischemia-reperfusion	38
Brain & Brain pet 2025 Abstracts	37
Baseline CBV-normalized BOLD fMRI of visual stimulation in awake vs. anesthetized mice	37

Dynamic neuroreceptor positron emission tomography in non-anesthetized rats using point source based motion correction: A feasibility study with [ 11	36
Post cardiac arrest physical exercise mitigates cell death in the septal and thalamic nuclei and ameliorates contextual fear conditioning deficits in rats	35
Temperature dysregulation during therapeutic hypothermia predicts long-term outcome in neonates with HIE	35
EXPRESSION OF CONCERN: Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matr	35
Nogo-A is secreted in extracellular vesicles, occurs in blood and can influence vascular permeability	33
RNF213 variant and autophagic impairment: A pivotal link to endothelial dysfunction in moyamoya disease	33
Plasminogen activator inhibitor-1 mediates cerebral ischemia-induced astrocytic reactivity	32
EXPRESS: Ventricular CSF-to-blood water transport kinetics in adult hydrocephalus	31
Phenotypic variability in 446 CADASIL patients: Impact of NOTCH3 gene mutation location in addition to the effects of age, sex and vascular risk factors	30
The effect of hypercapnia on the directional sensitivity of dynamic cerebral autoregulation and the influence of age and sex	30
Association of cognitive function and hypoperfusion in Moyamoya disease patients without stroke	30
Amyloid beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-AKT pathway	30
Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review	29
Endothelial glycocalyx degradation, systemic inflammation, and central nervous system injury: A comparative cohort study in adults with and without obesity	29
EXPRESS: Endothelial expression of human soluble epoxide hydrolase worsens acute microvascular and tissue injury after stroke in female mice with early-stage diabetes mellitus	29
Advances in artificial intelligence for neuroimaging	29
Meningeal CSF transport varies across parasagittal dura subregions with age in humans	28
Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis	28
EXPRESS: Parvalbumin interneurons contribute to spontaneous hemodynamic fluctuations	28
Co-transplantation of autologous treg cells: A groundbreaking cell therapy for brain diseases	27
Ironing out mechanisms of ferroptotic death to tailor new stroke therapies	27
Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence	27
Role of pterygopalatine ganglion in regulating isoflurane-induced cerebral hyper-perfusion	27
NK1 tachykinin receptor antagonist treatment reduces cerebral edema and intracranial pressure in an ovine model of ischemic stroke	26
A systematic review and in silico analysis of studies investigating the ischemic penumbra proteome in animal models of experimental stroke	26
Endothelial progenitor cell transplantation attenuates synaptic loss associated with enhancing complement receptor 3-dependent microglial/macrophage phagocytosis in ischemic mice	25
Characteristics of activation of monocyte-derived macrophages versus microglia after mouse experimental intracerebral hemorrhage	25
Incidence, severity and impact on functional outcome of persistent hypoperfusion despite large-vessel recanalization, a potential marker of impaired microvascular reperfusion: Systematic review of the	25
Reversible edema after radiosurgery for arteriovenous malformations (AVMs): Inflow and outflow imbalance	25
Elucidating stroke etiology through lipidomics of thrombi and plasma in acute ischemic stroke patients undergoing endovascular thrombectomy	25
Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation	24
Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke	24
Cerebrovascular morphology: Insights into normal variations, aging effects and disease implications	24
Thank you to reviewers	24
Characterizing pre- and post-operative cerebral blood flow and transit time in pediatric moyamoya patients using multi-delay ASL and DSC MRI	24
Magnetic resonance imaging indices for early Alzheimer’s disease detection: Brain clearance markers	24
Genetics of intracerebral hemorrhage	23
Where and how do leukocytes stall in retinal microcirculation: A spatiotemporal analysis with a focus on junctions and pericytes	23
Non-invasive [ 15 O]H 2 O PET measurements of cerebral perfusion and cerebrovascular reactivity us	23
The immediate functional and structural consequences of head-down tilt on the cranial venous vasculature and brain temperature	23
Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and S -nitrosothiol mediated signal transduction	23
Capillaries susceptible to frequent stall dynamics revealed by comparing OCT and bessel-2PM measurements	23
Cerebral O 2 and CO 2 transport in isovolumic haemodilution: Compensation of cerebral delivery of	23
A new framework for metabolic connectivity mapping using bolus [ 18 F]FDG PET and kinetic modeling	23
Targeting seryl-tRNA synthetase to unlock ischemic resilience in stroke – Insights from a proof-of-concept study	23
Statistical non-independence of brain metabolite concentrations whether normalized to creatine or water	23
Measuring capillary flow dynamics using interlaced two-photon volumetric scanning	22
Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI	22
Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study	22
Brain water dynamics across sleep stages measured by near-infrared spectroscopy: Implications for glymphatic function	22

Reliable infarction of the middle cerebral artery territory in C57BL/6 mice using pterygopalatine artery ligation and filament optimization – The PURE-MCAo model	22
Multimodal and serial MRI monitors brain peri-hematomal injury and repair mechanisms after experimental intracerebral hemorrhage	21
Cerebral multi-autoregulation model based enhanced external counterpulsation treatment planning for cerebral ischemic stroke	21
Transcriptome analyses of brain arteries and microvessels in male and female mice reveal prominent olfactory receptor gene and protein expression	21
Association between time-dependent changes in cerebrovascular autoregulation after cardiac arrest and outcomes: A prospective cohort study	21
Ferroptosis of microvascular pericytes contributes to ischemia–reperfusion injury in mice	21
A lone spike in blood glucose can enhance the thrombo-inflammatory response in cortical venules	20
High-resolution vasomotion analysis reveals novel arteriole physiological features and progressive modulation of cerebral vascular networks by stroke	20
Impaired dynamic cerebral autoregulation predicts silent ischemic lesions after carotid artery stenting: A hemodynamic biomarker beyond plaque morphology	20
Quantification of the purinergic P2X 7 receptor with [ 11 C]SMW139 improves through correction for	20
Focused ultrasound opens the blood–brain barrier and reveals an age-dependent dissociation between resting cerebral blood flow and neurovascular coupling	20
Micro-ultrasound based characterization of cerebrovasculature following focal ischemic stroke and upon short-term rehabilitation	20
Spatiotemporal analysis of blood plasma and blood cell flow fluctuations of cerebral microcirculation in anesthetized rats	20
Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach	19
Thanks to Reviewers	19
Quantitation of regional distribution of antibodies in rat brain following systemic and intra-CNS administration	19
Two possible hemodynamic mechanisms underlying the growth of cerebral aneurysms depending on their size: The NHO CFD ABO study	19
Rapid, selective and homogeneous brain cooling with transnasal flow of ambient air for pediatric resuscitation	19
Predictive value of cerebrovascular time constant for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage	18
Advances in three-dimensional modeling of ischemic injury	18
Preliminary investigations into human neurofluid transport using multiple novel non-contrast MRI methods	18
Commentary to “Ischemic conditioning promotes transneuronal survival and stroke recovery via CD36-mediated efferocytosis”	18
Characterizing the protective vasodilatory effects of hypobaric hypoxia on the neurovascular coupling response	18
Sex modifies the relationship between age and neurovascular coupling in healthy adults	18
Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan	18
Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population	18
Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury	17
Protective and pathogenic: The Janus-faced role of cGAS–STING in the brain	17
Associations of life-course cardiovascular risk factors with late-life cerebral hemodynamics	17
Lactate accumulates in the cerebrospinal fluid after prolonged exercise	17
Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders	17
Type 2 diabetes abates retrograde collateral flow and promotes leukocyte adhesion following ischemic stroke	17
Increased peripheral leukocyte aggravates brain injury and leads to poor outcome in stroke patients receiving intravenous thrombolysis: A study based on clinical evidence	17
Metabolic implications of axonal demyelination and its consequences for synchronized network activity: An in silico and in vitro	17
EXPRESS: It’s not all rapid dilations: on contributions of constrictions, biphasic and minute-long vessel responses to brain functional hyperemia	17
Assessing the effects of aging on the Koizumi’s and Zea Longa’s methods and their suitability as mouse models for evaluating neurodegeneration post-ischemic stroke: A comparative study	17
Mild hypercapnia before reperfusion reduces ischemia-reperfusion injury in hyperacute ischemic stroke rat model	17
Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease	17
Multifaceted neural and vascular pathologies after pediatric mild traumatic brain injury	16
Prophylactic PDE4 and PDE4B inhibition reduce lesion size and neutrophil infiltration following ischemic stroke in male mice	16
Targeted proteomic analysis identifies ACVRL1 as a marker of cerebral edema in aneurysmal subarachnoid hemorrhage	16
A novel model to quantify blood transit time in cerebral arteries using ASL-based 4D magnetic resonance angiography with example clinical application in moyamoya disease	16
In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging	16
Systematic review and meta-analysis of cognitive assessments used to detect deficits in the bilateral carotid artery stenosis model for vascular cognitive impairment	16
Extracellular vesicles lay the ground for neuronal plasticity by restoring mitochondrial function, cell metabolism and immune balance	16
EXPRESS: Bioenergetics of the combat sports brain: between risk and resilience	15
EXPRESS: Brain-derived tau: a promising biomarker for acute ischemic stroke	15
Trifluoperazine reduces infarct size, restores neurovascular coupling, and improves early outcomes in experimental acute ischemic stroke	15
EXPRESS: Cerebrovascular Reactivity Delay measured by Blood Oxygen Level Dependent Magnetic Resonance Imaging and Gas Challenges: A Systematic Review	15
Neurovascular coupling in early stage dementia – A case-control study	15
The age-associated decline in neuroplasticity and its implications for post-stroke recovery in animal models of cerebral ischemia: The therapeutic role of extracellular vesicles	15
Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications	15
β -hydroxybutyrate enhances brain metabolism in normoglycemia and hyperglycemia, providing cerebroprotection in a mouse stroke model	15
Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia	15
EXPRESS: Therapeutic Hypothermia Via Hypothalamic Neuromodulation: A New Approach for Stroke Brain Protection	15
Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan	15
Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke	14
Commentary to Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke	14
Antihypertensives in dementia: Good or bad for the brain?	14
Cerebral blood flow adaptations following 90 days head-down bed rest: Evidence from pseudo-continuous arterial spin labeling magnetic resonance imaging	14
Neural stem cell transplantation attenuates cognitive decline and neuroinflammation in a mouse model of Alzheimer’s disease with chronic cerebral hypoperfusion	14
Kinetic modeling of the monoamine oxidase-B radioligand [ 18 F]SMBT-1 in human brain with positron emission tomography	14
Zfp580 inactivation as a new therapeutic target to enhance recovery after stroke in mice	14
Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice	14
Global, regional and national burden of ischemic stroke attributed to high low-density lipoprotein cholesterol, 1990–2019：A decomposition analysis and age-period-cohort analysis	14
Network oscillatory dynamics accompany cerebral bioenergetic defence in hypoxia	14
Cerebral arterial stiffness is linked to white matter hyperintensities and perivascular spaces in older adults – A 4D flow MRI study	14
How processing choices effect repeatability in BOLD–CVR imaging	14
Reversal of the detrimental effects of social isolation on ischemic cerebral injury and stroke-associated pneumonia by inhibiting small intestinal γδ T-c	14
Treatment for moyamoya disease with hyperhomocysteinemia	14
Microglial histone deacetylase 2 is dispensable for functional and histological outcomes in a mouse model of traumatic brain injury	14
Using human genomics to validate drug targets for acute ischemic stroke	14
Heightened respiratory brain pulsations indicate fluid dynamic dysfunction in early multiple sclerosis	13
Single-tracer [ 18 F]FDG PET quantification of blood–brain barrier permeability and cerebral blood flow: Validation using dual-tracer PET	13
A dangerous liaison: Spreading depolarization and tissue acidification in cerebral ischemia	13
Non-classical monocytes promote neurovascular repair in cerebral small vessel disease associated with microinfarctions via CX3CR1	13
Neuropathological correlates of MRI-observed hypointense lesions in the APP23 mouse model of cerebral amyloid angiopathy	13
Brain-targeted mild hypothermia ameliorates ischemic brain injury and promotes stroke recovery in aged mice	13
Predicting brain temperature in humans using bioheat models: Progress and outlook	13
Control of neurovascular coupling by ATP-sensitive potassium channels	13

Effect of the duration of hypertension on white matter structure and its link with cognition	13
H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1	13
Ischemic core reversal on neuroimaging following endovascular reperfusion: A systematic review and meta-analysis	12
Acute psilocybin and ketanserin effects on cerebral blood flow: 5-HT2AR neuromodulation in healthy humans	12
A systematic observation of vasodynamics from different segments along the cerebral vasculature in the penumbra zone of awake mice following cerebral ischemia and recanalization	12
The miR-451a facilitates natural killer cell-associated immune deficiency after ischemic stroke	12
Time matters: Circadian effects on stroke pathophysiology	12
Neural and vascular contributions to sensory impairments in a human alpha-synuclein transgenic mouse model of Parkinson’s disease	12
Posterior communicating artery variation is linked to compromised cerebral hemodynamics in middle-aged and older adults	12
A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase	12
High-physiological and supra-physiological 1,2- 13 C 2 glucose focal supplementation to the trauma	12
“No-reflow” phenomenon in acute ischemic stroke	12
Pharmacological modulation of circadian rhythms in brain microvasculature	12
Point-Counterpoint: Cerebral perfusion pressure is a high-risk concept	12
Correcting SUVR bias by accounting for radiotracer clearance in tissue: A validation study with [ 18 F	12
The relationship between cytochrome c oxidase, CBF and CMRO 2 in mouse cortex: A NIRS-MRI study	12
Exploring brain glucose metabolism in multiple sclerosis: A deuterium metabolic imaging study	12
Systematic review and meta-analysis of transcranial doppler biomarkers for the prediction of delayed cerebral ischemia following subarachnoid hemorrhage	11
Diesel exhaust particles exposure exacerbates pro-thrombogenic plasma features ex-vivo after cerebral ischemia and accelerates tPA-induced clot-lysis in	11
Endothelial energy failure as a therapeutic target in elderly strokes	11
Metformin attenuates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion	11
Comparison of approaches for surface vessel diameter and pulsatility quantification	11
Airborne particulates and brain health: The role of PM 2.5 in blood-brain-barrier dysfunction	11
Antihypertensives in dementia: Good or bad for the brain?	11
Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review	11
Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change	11
Vascular topology and blood flow are acutely impacted by experimental febrile status epilepticus	11
DPSCs-Exos promote OPCs differentiation and white matter repair via Myl9-mediated PRMT5 nucleation after ischemic stroke	11
Post-endovascular treatment gyral hyperdensity sign: A warning sign preceding malignant cerebral edema in ischemic stroke	11
Insulin-stimulated brain glucose uptake correlates with brain metabolites in severe obesity: A combined neuroimaging study	11
Superior sagittal sinus flow as a proxy for tracking global cerebral blood flow dynamics during wakefulness and sleep	11
A plasma lipid signature in acute human traumatic brain injury: Link with neuronal injury and inflammation markers	11
Targeting angiogenesis and white matter repair for enhanced functional recovery after acute ischemic stroke: A focus on the roles of glial cells	11
Leukocyte indicators and variations predict worse outcomes after intravenous thrombolysis in patients with acute ischemic stroke	11
Accurate and fully automated diameter measurements of Circle of Willis arteries on MRA imaging	11
EXPRESS: Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC	11
A perivascular perspective on the immune impacts in cerebral amyloid angiopathy	11
Mechanical compaction alters microstructural and magnetic resonance imaging properties of acute ischemic stroke clots	11
Neutrophil-derived cathelicidin promotes cerebral angiogenesis after ischemic stroke	11
Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury	11
A reference-based PET/MRI method for quantifying activation-induced changes in cerebral oxygen metabolism	11
Pretreatment with oleuropein protects the neonatal brain from hypoxia-ischemia by inhibiting apoptosis and neuroinflammation	10
Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal	10
Optimal filtering strategies for task-specific functional PET imaging	10
Unveiling m7G modification patterns and causal drivers governing intracranial aneurysm rupture risk through multi-omics validation and m7G-MeRIP-seq profiling	10
Delayed administration of type II ampakines enhance synaptic plasticity and cognitive recovery in juvenile global cerebral ischemia	10
Imaging the 5-HT 2C receptor with PET: Evaluation of 5-HT 2C and 5-HT 2A<	10
Growth arrest specific protein 6 alleviated white matter injury after experimental ischemic stroke	10
Role of miRNAs in neurovascular injury and repair	10
Astrocyte-driven multicellular mechanisms of CNS repair and cerebroprotection	10
TSPO deficiency exacerbates acute brain damage after intracerebral hemorrhage in male mice	10
Associations between admission levels of multiple biomarkers and subsequent worse outcomes in acute ischemic stroke patients	10
Editorial to the special issue on extracellular vesicles and mitochondria in CNS function and disease	10
Alpha-adrenergic receptor activation after fetal hypoxia-ischaemia suppresses transient epileptiform activity and limits loss of oligodendrocytes and hippocampal neurons	10
Type-1-to-type-2 transition of brain microvascular pericytes induced by cytokines and disease-associated proteins: Role in neuroinflammation and blood-brain barrier disruption	10
An automatic analysis framework for FDOPA PET neuroimaging	10
Direct glia-to-neuron conversion mitigates hippocampal damage in a vascular dementia mouse model	10
Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer’s disease	10
Isoform-selective and non-selective rho-kinase inhibitors do not affect collagenase-induced intracerebral hemorrhage outcomes in mice: Influence of sex and circadian cycle	10