Journal of Cerebral Blood Flow and Metabolism

Article	Citations
Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke	119
Body mass index, time of day and genetics affect perivascular spaces in the white matter	65
Causes and consequences of baseline cerebral blood flow reductions in Alzheimer’s disease	64
Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update	60
Mitochondrial quality control in acute ischemic stroke	60
Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvessels	57
Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study	53
Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome	42
Three-dimensional ultrastructure of the brain pericyte-endothelial interface	42
Altered glymphatic enhancement of cerebrospinal fluid tracer in individuals with chronic poor sleep quality	41
Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with 15O PET in healthy adults	40
Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model	40
PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflamm	38
Deep white matter hyperintensity is associated with the dilation of perivascular space	38
Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective	38
Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET	37
Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion	37
Role of perivascular and meningeal macrophages in outcome following experimental subarachnoid hemorrhage	36
Change and predictive ability of circulating immunoregulatory lymphocytes in long-term outcomes of acute ischemic stroke	35
Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study	34
Integrative cerebral blood flow regulation in ischemic stroke	34
Glymphatic pathways in the gyrencephalic brain	33
Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients	33
Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury	32
Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice	32

Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging	31
Cerebrovascular phenotypes in mouse models of Alzheimer’s disease	31
Microglial phagocytosis and regulatory mechanisms after stroke	30
Microvascular changes associated with epilepsy: A narrative review	30
Aging related impairment of brain microvascular bioenergetics involves oxidative phosphorylation and glycolytic pathways	29
Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview	29
Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults	29
Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue	29
Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development	29
Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition	29
Choroid plexus function in neurological homeostasis and disorders: The awakening of the circadian clocks and orexins	28
Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission	27
How expensive is the astrocyte?	27
Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study	27
Functional dynamics of dopamine synthesis during monetary reward and punishment processing	26
Lenticulostriate artery combined with neuroimaging markers of cerebral small vessel disease differentiate the pathogenesis of recent subcortical infarction	26
Aerobic exercise improves hippocampal blood flow for hypertensive Apolipoprotein E4 carriers	26
In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease	26
Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke	26
Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study	25
Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment	25
Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy	25
Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage	25
A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: From normal physiology to pathophysiological changes	25
Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction	24
Targeting neutrophils as a novel therapeutic strategy after stroke	24
Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury	24
In vivo synaptic density relates to glucose metabolism at rest in healthy subjects, but is strongly modulated by regional differences	24
Metabolic underpinnings of activated and deactivated cortical areas in human brain	23
Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke	23
Cerebral ischemia in the developing brain	23
More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke	23
Oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt/β-catenin pathway in a mouse model of middle cerebral artery occlusion	23
Linking cortical atrophy to white matter hyperintensities of presumed vascular origin	23
Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci	23
Review of treatment and therapeutic targets in brain arteriovenous malformation	23
The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders	22
Low neuronal metabolism during isoflurane-induced burst suppression is related to synaptic inhibition while neurovascular coupling and mitochondrial function remain intact	22
Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study	22
Reliability and validity of the mean flow index (Mx) for assessing cerebral autoregulation in humans: A systematic review of the methodology	22
Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep	22
Effect of uric acid in animal models of ischemic stroke: A systematic review and meta-analysis	22
Connexin43 promotes angiogenesis through activating the HIF-1α/VEGF signaling pathway under chronic cerebral hypoperfusion	22
Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture	21
Role of endothelium-pericyte signaling in capillary blood flow response to neuronal activity	21
Reliability of task-specific neuronal activation assessed with functional PET, ASL and BOLD imaging	21
Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences	21
A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit	21
Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult	21
Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury	21

Hypoxemia increases blood-brain barrier permeability during extreme apnea in humans	21
Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease	21
Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway	20
[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain	20
Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging	20
Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics	20
A line through the brain: implementation of human line-scanning at 7T for ultra-high spatiotemporal resolution fMRI	20
MRI-visible perivascular spaces in basal ganglia but not centrum semiovale or hippocampus were related to deep medullary veins changes	20
A large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain	19
Changes in synaptic density in the subacute phase after ischemic stroke: A 11C-UCB-J PET/MR study	19
Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan	19
Effects of increased intracranial pressure on cerebrospinal fluid influx, cerebral vascular hemodynamic indexes, and cerebrospinal fluid lymphatic efflux	19
CNS-peripheral immune interactions in hemorrhagic stroke	19
Effects of O-GlcNAcylation on functional mitochondrial transfer from astrocytes	19
White matter network damage mediates association between cerebrovascular disease and cognition	19
Cerebral blood flow measurements with 15O-water PET using a non-invasive machine-learning-derived arterial input function	19
Poor venous outflow profiles increase the risk of reperfusion hemorrhage after endovascular treatment	19
The central role of peripheral inflammation in ischemic stroke	18
Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI	18
A novel method of quantifying hemodynamic delays to improve hemodynamic response, and CVR estimates in CO2 challenge fMRI	18
Leptomeningeal collateral activation indicates severely impaired cerebrovascular reserve capacity in patients with symptomatic unilateral carotid artery occlusion	18
Longitudinal cortex-wide monitoring of cerebral hemodynamics and oxygen metabolism in awake mice using multi-parametric photoacoustic microscopy	18
Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain	18
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke	18
Altered regional cerebral blood flow in obstructive sleep apnea is associated with sleep fragmentation and oxygen desaturation	18
Selective intra-carotid blood cooling in acute ischemic stroke: A safety and feasibility study in an ovine stroke model	18
Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes via α2 adrenergic receptors	18
A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models	18
The roles of microglia and astrocytes in myelin phagocytosis in the central nervous system	17
Assessing cerebral arterial pulse wave velocity using 4D flow MRI	17
One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults	17
Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis: Proposed mechanisms and clinical implications	17
Hemispheric CSF volume ratio quantifies progression and severity of cerebral edema after acute hemispheric stroke	17
Principles and requirements for stroke recovery science	17
Cerebral critical closing pressure and resistance-area product: the influence of dynamic cerebral autoregulation, age and sex	17
Inflammation-relevant microbiome signature of the stroke brain, gut, spleen, and thymus and the impact of exercise	16
Using arterial spin labeling to measure cerebrovascular reactivity in Moyamoya disease: Insights from simultaneous PET/MRI	16
CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome	16
Tenascin-C induction exacerbates post-stroke brain damage	16
Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2	16
Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling	16
Role of platelets in the pathogenesis of delayed injury after subarachnoid hemorrhage	16
MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice	16
Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein	16
Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans	16
pH and proton-sensitive receptors in brain ischemia	16
Hemodynamic and structural brain measures in high and low sedentary older adults	16
Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease	16
Impact of meningeal uptake and partial volume correction techniques on [18F]MK-6240 binding in aMCI patients and healthy controls	15
Sex modifies the relationship between age and neurovascular coupling in healthy adults	15
The INfoMATAS project: Methods for assessing cerebral autoregulation in stroke	15
Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease	15
Dilated perivascular space is related to reduced free-water in surrounding white matter among healthy adults and elderlies but not in patients with severe cerebral small vessel disease	15
Systematic review: Association between circulating microRNA expression & stroke	15
Brain oxygen extraction fraction mapping in patients with multiple sclerosis	15
Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and S-nitrosothiol mediated signal transduction	15
Cerebral endothelial cell-derived small extracellular vesicles enhance neurovascular function and neurological recovery in rat acute ischemic stroke models of mechanical thrombectomy and embolic strok	15
Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice	15
Integrative analysis of the human brain mural cell transcriptome	15
Impaired damping of cerebral blood flow velocity pulsatility is associated with the number of perivascular spaces as measured with 7T MRI	15
Blood-brain barrier disruption measured by albumin index correlates with inflammatory fluid biomarkers	15
Increased capillary stalling is associated with endothelial glycocalyx loss in subcortical vascular dementia	15
Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques*	15
A functional cerebral endothelium is necessary to protect against cognitive decline	14
Free-water diffusion MRI detects structural alterations surrounding white matter hyperintensities in the early stage of cerebral small vessel disease	14
Phenotypic variability in 446 CADASIL patients: Impact of NOTCH3 gene mutation location in addition to the effects of age, sex and vascular risk factors	14
Repeated hypoxia exposure induces cognitive dysfunction, brain inflammation, and amyloidβ/p-Tau accumulation through reduced brain O-GlcNAcylation in zebrafish	14
An enriched environment improves long-term functional outcomes in mice after intracerebral hemorrhage by mechanisms that involve the Nrf2/BDNF/glutaminase pathway	14
High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states	14
Astrocyte regulation of cerebral blood flow during hypoglycemia	14
Impact of blood pressure changes in cerebral blood perfusion of patients with ischemic Moyamoya disease evaluated by SPECT	14
Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?	14
Metabolomic and transcriptional profiling reveals bioenergetic stress and activation of cell death and inflammatory pathways in vivo after neuronal deletion of NAMPT	13
Telmisartan prevents high-fat diet-induced neurovascular impairments and reduces anxiety-like behavior	13
Choroid plexus perfusion in sickle cell disease and moyamoya vasculopathy: Implications for glymphatic flow	13
Cell-specific expression and function of laminin at the neurovascular unit	13
A cluster of blood-based protein biomarkers reflecting coagulation relates to the burden of cerebral small vessel disease	13
Neurovascular coupling on trial: How the number of trials completed impacts the accuracy and precision of temporally derived neurovascular coupling estimates	13
Hyperoxia evokes pericyte-mediated capillary constriction	13
Normative distribution of posterior circulation tissue time-to-maximum: Effects of anatomic variation, tracer kinetics, and implications for patient selection in posterior circulation ischemic stroke	13

Deep medullary veins are associated with widespread brain structural abnormalities	12
Long-term monitoring of chronic demyelination and remyelination in a rat ischemic stroke model using macromolecular proton fraction mapping	12
β2 glycoprotein I participates in phagocytosis of apoptotic neurons and in vascular injury in experimental brain stroke	12
Reduction of neuroinflammation alleviated mouse post bone fracture and stroke memory dysfunction	12
Evaluation of single bolus, dual-echo dynamic susceptibility contrast MRI protocols in brain tumor patients	12
Whole-brain perfusion mapping in mice by dynamic BOLD MRI with transient hypoxia	12
Validation, kinetic modeling, and test-retest reproducibility of [18F]SynVesT-1 for PET imaging of synaptic vesicle glycoprotein 2A in mice	12
Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease	12
Imaging biomarkers of vascular and axonal injury are spatially distinct in chronic traumatic brain injury	12
Epigenetic mechanisms and potential therapeutic targets in stroke	12
Deep learning-based identification of acute ischemic core and deficit from non-contrast CT and CTA	12
Progranulin released from microglial lysosomes reduces neuronal ferroptosis after cerebral ischemia in mice	12
Common and unique structural plasticity after left and right hemisphere stroke	12
Metabolic MRI with hyperpolarized [1-13C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke	12
Reproducibility of findings in modern PET neuroimaging: insight from the NRM2018 grand challenge	12
Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2-13C]/[1-13C	12
Activin A alleviates neuronal injury through inhibiting cGAS-STING-mediated autophagy in mice with ischemic stroke	12
Age-related impairment of cerebral blood flow response to KATP channel opener in Alzheimer’s disease mice with presenilin-1 mutation	12
Cerebral perfusion in untreated, controlled, and uncontrolled hypertension	12
Wiring and plumbing: Oligodendrocyte precursors and angiogenesis in the oligovascular niche	12
A CBF decrease in the left supplementary motor areas: New insight into postoperative pediatric cerebellar mutism syndrome using arterial spin labeling perfusion MRI	11
Amyloid-β disrupts unitary calcium entry through endothelial NMDA receptors in mouse cerebral arteries	11
Association between the time of day at stroke onset and functional outcome of acute ischemic stroke patients treated with endovascular therapy	11
Three-dimensional remodeling of functional cerebrovascular architecture and gliovascular unit in leptin receptor-deficient mice	11
Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons	11
T2 relaxation time of the normal-appearing white matter is related to the cognitive status in cerebral small vessel disease	11
Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice	11
Role of microcirculatory impairment in delayed cerebral ischemia and outcome after aneurysmal subarachnoid hemorrhage	11
The effect of hypercapnia on the directional sensitivity of dynamic cerebral autoregulation and the influence of age and sex	11
Prolonged release of VEGF and Ang1 from intralesionally implanted hydrogel promotes perilesional vascularization and functional recovery after experimental ischemic stroke	11
H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1	11
Redefining the Koizumi model of mouse cerebral ischemia: A comparative longitudinal study of cerebral and retinal ischemia in the Koizumi and Longa middle cerebral artery occlusion models	11
Cerebrovascular and neurological perspectives on adrenoceptor and calcium channel modulating pharmacotherapies	11
Endovascular administration of magnetized nanocarriers targeting brain delivery after stroke	11
Hemodynamic and metabolic changes during hypercapnia with normoxia and hyperoxia using pCASL and TRUST MRI in healthy adults	11
Regional and depth-dependence of cortical blood-flow assessed with high-resolution Arterial Spin Labeling (ASL)	11
A systematic observation of vasodynamics from different segments along the cerebral vasculature in the penumbra zone of awake mice following cerebral ischemia and recanalization	11
Review of major trials of acute blood pressure management in stroke	11
Cohort study on the differential expression of inflammatory and angiogenic factors in thrombi, cerebral and peripheral plasma following acute large vessel occlusion stroke	11
Hemodynamic and oxygen-metabolic responses of the awake mouse brain to hypercapnia revealed by multi-parametric photoacoustic microscopy	11
Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life	11
Depth-profile of impairments in endothelin-1 – induced focal cortical ischemia	11
Red blood cells as glucose carriers to the human brain: Modulation of cerebral activity by erythrocyte exchange transfusion in Glut1 deficiency (G1D)	11
Directional sensitivity of dynamic cerebral autoregulation during spontaneous fluctuations in arterial blood pressure at rest	11