OOIR: Observatory of International Research

Papers

(The TQCC of Biomedical Chromatography is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
The Isolation and Separation of Hydrophobic Bioactive Peptide Obtained From Tilapia ( Oreochromis niloticus	45
A Validated UPLC‐MS/MS Method for Monitoring Temozolomide and Perillyl Alcohol Metabolites in Biological Matrices: Insights From a Preclinical Pharmacokinetic Study	38
Development of a simultaneous quantification method of imatinib and sunitinib and their main metabolites and its application in patients with gastrointestinal stromal tumor	30
Issue Information	26
Identification of Dendrobium devonianum Samples With Different Growth Years Based on Active Ingredients and Deduction of the Chemical Structural Transformation	26
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Development of simultaneous quantitative analytical method for metabolites of hexosamine biosynthesis pathway in lung cancer cells using ultra‐high‐performance liquid chromatography‐tandem mass spectr	23
Mango peel extracts and mangiferin chromatographic Fourier‐transform infrared correlation with antioxidant, antidiabetic, and advanced glycation end product inhibitory potentials using in silico model	22
Issue Information	22
Preparation of 5‐hydroxymethylfurfural from Schisandra chinensis (Turcz.) Baill by high‐speed counter‐current chromatography: Comparison of conventional and consecutive separation	22
Development of stability‐indicating method for separation and characterization of benidipine forced degradation products using LC–MS/MS	21
Evaluation of various polysaccharide‐based stationary phases for enantioseparation of chloro‐containing derivatives in normal phase liquid chromatography	20
Interference Assessment for High‐Performance Liquid Chromatography HbA1c Assays	20
Pioneering Human Plasma Detection of Haloperidol With 5‐pg/mL Sensitivity via Refined Sample Preparation and Advanced LC–MS/MS	20
Assessment of Apalutamide Metabolic Stability in HLMs Matrix Using a Sensitive and Fast UPLC‐MS/MS Method: In Silico Screening for Toxicity Alerts and Metabolic Lability	20
Separation and Identification of Impurity of Chlortetracycline Hydrochloride Not Included in the European Pharmacopoeia	20
Green Ultra‐Fast UPLC–MS/MS Method for Enasidenib Quantification in HLMs Matrix With the Metabolic Stability Assessment: In Silico Study for Structural Alerts, ADME Characteristics and Metaboslic Labi	20
An LC–MS/MS Method for the Quantitation of Metabolites M9, M12, and M20 of Bexicaserin in Human Cerebrospinal Fluid	18
Integrative LC–MS/MS, Bioinformatics, and Molecular Dynamics Reveal Multitarget Antioxidant Mechanisms of Bushen Huoxue Decoction in Intervertebral Disc Degeneration	18
Matrix effect in bioanalytical assay development using supercritical fluid chromatography‐mass spectrometry	16
The pharmacokinetics and tissue distribution of curcumin following inhalation administration in rats—A comparative analysis with oral and intravenous routes	16
A Robust LC‐MS/MS Bioanalytical Strategy for Simultaneous Quantification of Tramadol HCl and Dexketoprofen Trometamol and Its Use in Pharmacokinetic Studies	16
Lipidomics reveals the serum profiles of pediatric allergic rhinitis and its severity	15
Simultaneous Determination of Four Active Ingredients in Snow Chrysanthemum by HPLC With Determination of Its Antioxidant Activity in Vitro	15
In vivo detection of the epimer metabolites of sweroside via ultra‐performance liquid chromatography time‐of‐flight mass spectrometry combined with DNPH derivatization	15

Characterization and Analytical Method Validation for Potential Impurities of a Merchantability Drug Substance Fluoxetine HCl	15
An UHPLC–QTOF–MS‐based strategy for systematic profiling of chemical constituents and associated in vivo metabolites of a famous traditional Chinese medicine formula, Yinchenhao decoction	14
Detection and identification of imperatorin metabolites in rat, dog, monkey, and human liver microsomes by ultra‐high‐performance liquid chromatography combined with high‐resolution mass spectrometry	14
Pharmacokinetics and Metabolism of ARV‐393, a BCL6 PROTAC Degrader, in Dogs by UPLC–MS/MS and UPLC‐Q‐Exactive Orbitrap‐HRMS	14
Residue levels and risk assessment of acetamiprid–pyridaben mixtures in cabbage under various open field conditions	14
Validation of an HPLC‐UV for Apixaban Stability‐Indicating Study	14
Screening for α‐glucosidase inhibitors from Selaginella uncinata based on the ligand fishing combined with ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight–tandem m	13
A Comprehensive Review of Analytical Techniques for Doxycycline and Its Metabolites	13
RP‐HPLC method development, validation and pharmacokinetic applicability in preclinical evaluation of rhein treated with novel diacerein eutectics	13
Metabolomics Reveals the Mechanism of American Ginseng in Alleviating Insulin Resistance by Reversing Metabolic Disorders in HepG2 Cells	13
Development of a joint derivatization protocol for the unequivocal identification of the monosaccharide composition in four dendrobium polysaccharides and free monosaccharide by GC–MS	13
Development and validation of novel RP‐HPLC method for midostaurin determination using analytical quality by design approach from regulatory perspective and determination of major degradation compound	13
Evaluation of lipophilicity and drug‐likeness of donepezil‐like compounds using reversed‐phase thin‐layer chromatography	13
Therapeutic potential of Shaoyao Gancao Decoction in mitigating anti‐tuberculosis drug‐induced liver injury through Nrf‐2/HO‐1/NF‐κB signaling	13
Spectroscopic characterization and pharmacokinetic evaluation of amorphous solid dispersions of glibenclamide for bioavailability enhancement in Wistar rats	12
Development and validation of gas chromatography with electron capture detection method using QuEChERS for pesticide residue determination in cucumber	12
Investigation of the therapeutic effect of Hedan tablets on high‐fat diet‐induced obesity in rats by GC–MS technology and 16S ribosomal RNA gene sequencing	12
Metabolic Profiling of 5‐Methoxypinocembroside and Pharmacokinetics Study of Its Major Metabolite Alpinetin in Rat Plasma by UHPLC–MS	12
The Effect of Kaempferol on Valsartan Metabolism In Vitro and In Vivo and the Underlying Mechanism With Cytochrome p450 Using UPLC‐MS/MS	12
Potential role of the methanolic extract for Olea europaea (stem and leaves) on sporulation of Eimeria papillata oocysts: In vitro study	11
Issue Information	11
Study on Quality Markers for Hypoglycemic Effects of Moringa oleifera Leaves by the Integration of	11
Delineation of prototypical degradation mechanism, characterization of unknown degradation impurities by liquid chromatography–quadrupole‐time‐of‐flight–tandem mass spectrometry and stability‐indicati	11
Determination of three C18‐oxygenated steroids in adrenal lesion segments in primary aldosteronism by super‐selective adrenal venous sampling and LC/ESI–MS/MS	11
Online preconcentration and determination of five alkaloids in Yangxinshi tablet by large‐volume sample stacking and micelle to solvent stacking in cyclodextrin‐modified electrokinetic chromatography	11
Integrated Experimental and Computational Evaluation of the Gut‐Targeted Anticoccidial Potential of Agaricus bisporus Methanolic Extract	11
Screening of Antiaging Active Components of Morinda officinalis and the Mechanism of Enhanced Efficacy After Salt‐Steaming	11
Issue Information	11
Multimodal Metabolomics Analysis Reveals That Classic Decoction Mitigates Myocardial Ischemia‐Induced Damage by Modulating Energy and Branched‐Chain Amino Acid Metabolism	11
Comprehensive Evaluation of Growth Period Variations in Bioactive Properties and Phytochemical Profiles of Aesculus chinensis Bge Seeds and Leaves	11
Development and validation of a stability‐indicating ultra‐high‐performance liquid chromatography method for the estimation of ibrutinib and trace‐level quantification of related substances using qual	10
Comparative phytochemical study of methanolic and ethanolic extracts of Thymus linearis and their antibacterial and antioxidant potential	10
Pharmacokinetic and pharmacodynamic herb–drug interactions of common over‐the‐counter pain medications	10
Insight gained via ultra‐performance liquid chromatography tandem mass spectrometry‐based metabolomics: Protective effect of Artemisia argyi H.Lév. & Vaniot essential oil on lipopolysacchar	10
Effect of concomitant oral administration of ethanol on the pharmacokinetics of nicardipine in rats	10
Chromatographic analysis and antioxidant potency of the crude extract of Xanthium spinosum in various fractions	10
Application of Proteomics in the Study of Toxicology and Toxic Markers of Traditional Chinese Medicines	10
Si Miao San relieves hyperuricemia by regulating intestinal flora	10
Development and Validation of a UPLC‐MS/MS Method for the Determination of Apalutamide in Human Plasma and Its Application in a Bioequivalence Study	10
Comparative analysis of the liver‐protective effects of raw and stir‐fried semen of Hovenia dulcis in rats via gas chromatography–mass spectrometry–based serum metabolomic profiling	9
Lateal Flow Immunoassay for Sensitive and Rapid Detection of Methylisomiroestrol in Pueraria candollei Using Monoclonal Antibody	9
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A Simple Rapid HPLC‐UV Method for Assessing C‐Terminal Arginine Content in Darbepoetin Alfa	9
Determination of 59 Psychotropic Drugs, Including Antipsychotics, Antidepressants, Antiepileptics, Anti‐Alcohol Abuse Drugs, Anti‐ADHD Drugs, and Their Metabolites in Urine Using LC–MS/MS for Medicati	9
Rapid Analysis of Chemical Constituents in Blachia pentzii Leaves and Predictive Analysis of the Pharmacological Effects for Treatment of Rheumatoid Arth	9
Determination of Schaftoside and Isoschaftoside in Rat Plasma Utilizing UPLC‐MS/MS	9
Dissipation and Risk Assessment of a Combination Product of Chlorantraniliprole + Abamectin and Spirotetramat in Pomegranate Fruit and Juice	9
Spectrum–effect relationship between HPLC fingerprint and hypoglycemic of litchi leaves (Litchi chinensis Sonn) in vitro	9
Process Optimization of Stir‐Fried Inonotus hispidus Based on the Box–Behnken Design‐Response Surface Method and the Component Variations During the Stir‐Frying Process	9
A liquid chromatography–tandem mass spectrometry method development for the quantification of favipiravir drug and its related impurities in rat plasma and its application to pharmacokinetic studies	9

Dissipation Kinetics, Risk Assessment, and Decontamination Studies of Pyridalyl in Cabbage by GC–MS/MS	9
An LC–ESI–MS/MS assay for the therapeutic drug monitoring of 15 antiseizure medications in plasma of children with epilepsy	8
Serum and urine metabolomics based on UPLC–QTOF/MS reveal the effect and potential mechanism of “schisandra–evodia” herb pair in the treatment of Alzheimer's disease	8
Bioanalytical UHPLC–MS/MS Method for Quantification of Terbinafine in Ungual Delivery Studies	8
Investigating the in vivo effect of Tribulus terrestris extract in middle cerebral artery occlusion rats using LC–MS‐based metabolomics combined with molecular docking	8
Amelioration of Guishao Yigong Decoction on Colorectal Cancer Through the Integration of 16S rRNA Sequencing and Fecal Metabolomics	8
LC–MS/MS method for quick detection of vonoprazan fumarate in human plasma: Development, validation and its application to a bioequivalence study	8
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A pharmacokinetics interaction study of antiplatelet agents aspirin and clopidogrel combined with dl‐3‐n‐butylphthalide in rats by liquid chromatography–tandem mass spectrometry	8
Simultaneous Determination of Buspirone, Alprazolam, Clonazepam, Diazepam, and Lorazepam by LC‐MS/MS: Evaluation of Greenness Using AGREE Tool	8
Chromatography in Preparative/Industrial Scale Separation of Enantiomeric Mixtures	8
Serum metabolome analysis reveals medicinal fungi Phellinus igniarius ameliorated type 2 diabetes mellitus indications in rats via modulation of amino acid and carbohydrate metabolism	8
Hybrid solid‐phase extraction to overcome interference due to phospholipids for determination of neratinib in human plasma using UPLC–MS/MS	8
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Simultaneous quantitation of urine aldosterone and tetrahydroaldosterone in healthy Chinese subjects using a validated LC–MS/MS method	8
Beyond the Database: Integration of Network Pharmacology and UHPLC‐QTOF‐MS/MS to Reveal the Neuroprotective Potential of Bai Mi Decoction in Stroke Therapy	8
Quality Difference Analysis of Pomegranate Peels Based on Multidimensional Fingerprint With Chemical Pattern Recognition	8
Sustainable RP‐HPLC Method Development Using AQbD Approach for Simultaneous Estimation of Valganciclovir Hydrochloride and Piperine‐Loaded Lipid Nanoparticles	8
Supercritical fluid chromatography for milligram preparation of enantiomers	8
Identification of the Absorbed Constituents and Metabolites of Shenyanshu Tablets in Rat Plasma by Ultrahigh‐Performance Liquid Chromatography Coupled With Quadrupole Time‐of‐Flight Mass Spectrometry	8
Assessment of remdesivir and its nucleoside metabolite in beagle dogs and healthy humans by liquid chromatography coupled with triple quadrupole mass spectrometry	8
Pharmacokinetics, Mass Balance, and Metabolism of [ ¹⁴ C]TPN729, a Selective and Potent Phosphodiesterase Type 5 Inhibitor in Humans	8
Supported liquid extraction combined with liquid chromatography tandem mass spectrometry for the quantitative analysis of a TLR7 agonist imiquimod LFX453 in plasma at low picograms per milliliter: Met	8
The Complex Formation Between Ginsenosides and Glutathione Utilized in Cosmetics to Promote Transdermal Absorption and Mask the Bad Odor of Glutathione	8
Effect of Fuzheng Pill on Liver Cancer via the Mitochondrial Apoptosis Pathway	7
A Simple, Sensitive, and Stable LC–MS/MS Method for the Simultaneous Determination and Pharmacokinetic Study of Dapagliflozin and Its Metabolite D3OG in Human Plasma	7
Metabolomics and serum pharmacochemistry revealed the preventive mechanism of Gushudan in kidney‐yang‐deficiency‐syndrome rats	7
Metabolite Identification of Huangqi Guizhi Wuwu Granules in Rat Urine and Feces Based on Ultra–High‐Performance Liquid Chromatography With Quadrupole Time‐of‐Flight Mass Spectrometry	7
A simple, high‐throughput and validated LC–MS/MS method for the determination of azithromycin in human plasma and its application to a clinical pharmacokinetic study	7
Development and Validation of a Rapid and Simple UHPLC–MS/MS Method for the Determination of Colchicine in Human Plasma	7
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Quantitation of tazemetostat in human plasma using liquid chromatography–tandem mass spectrometry	7
Network pharmacology study on fermented soybeans for the prevention of Alzheimer's disease in older individuals	7
Anticoccidial Effects of Tirmania nivea Extract and In Silico Evaluation of Its Phytochemicals Against Eimeria	7
LC–MS/MS Assay for Simultaneous Quantification of Dual‐Targeting 1,5‐Diaryl‐1,2,4‐Triazole Sulfonamides (WA11–13) in Human Plasma	7
Metabolic Profile In Vivo and Potential Mechanisms of Danggui Jianzhong Decoction Against Gastric Ulcer by Ultra‐High‐Performance Quadrupole Time‐of‐Flight Mass Spectrometry Combined With Network Phar	7
Impact of introducing a new biological matrix into a validated bioanalytical method: Focus on matrix protein content	7
A Simple Eco‐Friendly Stability‐Indicating HPLC Method for Determination of NETILMICIN in Bulk and Ophthalmic Solution	7
The delivery of nanoparticles improves the pharmacokinetic properties of celecoxib to open a therapeutic window for oral administration of insoluble drugs	7
Metabolism of the Total Flavonoid Extract of Lithocarpus litseifolius (Hance) Chun in Rats	7
Phytochemical profile and pharmacological potential of Withania somnifera whole plant extracts	7
A selective, sensitive and fast LC–MS/MS method for cabotegravir quantification in rat plasma and pharmacokinetic investigations	7
An effective LC–MS method for the simultaneous determination of a potential anti‐rheumatoid arthritis drug, carboxyamidotriazole, and its major metabolite in rat plasma	7
UPLC Estimate of Sofosbuvir and Ledipasvir Utilizing Greenness Tool in Conjunction With an Analytical Quality by Design	7
Human plasma ricinine quantification by LC–HRMS after micro‐solid‐phase elution	7
Quantitative Determination and Stability of Trace Levels of Oxytocin in Human and Rhesus Macaque Urine by LC–MS/MS	7
Optimization of Environmentally Sustainable UPLC‐PDA Method Using Box–Behnken for Simultaneous Quantifying Curcumin and Candesartan Cilexetil in On‐Demand Formulation for Treatment of Brain Ischemic I	7
Farfarae Flos Mitigates Cigarette Smoking‐Induced Lung Inflammation by Regulating the Lysophosphatidylcholine Biosynthesis and Tryptophan Metabolism	7
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Comparative Chromatographic Analysis of Amino Acids in the Seeds of Three Nigella L. Representatives	7
Degradation pathways and impurity profiling of the anticancer drug apalutamide by HPLC and LC–MS/MS and separation of impurities using Design of Experiments	6
Comparative analysis of six aconitine‐type alkaloids in decocting extracts between the different processed Fuzi (Aconiti Lateralis Radix praeparata) and its pharmacokinetic behavior in rats by HPLC‐MS	6
Unraveling the Mechanisms of Modified Si Miao San in Treating Gouty Arthritis: Network Pharmacology and Experimental Validation	6
Method validation, dissipation and residue status of fluopicolide and fosetyl‐aluminium in citrus using a rapid extraction method coupled with ultra‐performance liquid chromatography–tandem mass spect	6
Dispersive liquid–liquid microextraction and Monte Carlo simulation of margin of safety for octocrylene, EHMC, 2ES, and homosalate in sunscreens	6
Determination of the dissipative behaviour and final residue of sodium nitrophenol in jujube by liquid chromatography–tandem mass spectrometry	6
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Identification of the metabolites of nimbolide in rat by liquid chromatography combined with quadrupole/orbitrap mass spectrometry	6
Issue Information	6
Integrative In Vivo and Transcriptomics‐Guided In Silico Profiling of Citrus sinensis Phytochemica	6
Discovery of Q‐Markers of Mudan Granules by Chemical Profile, Pharmacokinetics, Neuroprotective Effect Evaluation, and Network Pharmacology	6
Green method by National Environmental Methods Index and Eco‐Scale Assessment for evaluation of gatifloxacin‐based product by HPLC	6
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Investigation of the Potential Material Basis and Mechanism of Astragali Radix Against Adriamycin‐Induced Nephropathy Model Rat by ¹H NMR and MS‐Based Untargeted Metabolomics Analysis	6
First Establishment of LC–MS/MS Method for Quantitative Analysis of Pharmacokinetics and Tissue Distribution of Trilobatin—Comparison of Three Administration Modes	6
Development and Validation of HPTLC Method for Estimation of Podophyllotoxin in Crude Extract, Isolated Podophyllotoxin and Marketed Mother Tincture of	6
The JAK2^V617F mutation and childhood type1 diabetic nephropathy?	6
Spectrum–effect relationship study between ultra‐high‐performance liquid chromatography fingerprints and anti‐hepatoma effect in vitro of Cnidii Fructus	6
LC–MS/MS determination of HY072808, a novel candidate for treating atopic dermatitis, and its active metabolite: Application to a first‐in‐human pharmacokinetic study	6
Simultaneous Quantification of Filgotinib and Its Active Metabolite in Human Plasma Using Liquid Chromatography–Tandem Mass Spectrometry: Validation and Clinical Application	6
Chemical characterization, multivariate analysis and comparison of biological activities of different parts of Fraxinus mandshurica	6
A Simple and Sensitive LC‐MS/MS Method for the Determination of Mobocertinib and Its Metabolite Desmethyl‐Mobocertinib in Human Plasma and Its Application to Clinical Pharmacokinetic Study	6
A novel LC–MS/MS approach to [¹⁹F]‐alfatide and alfatide for application in preclinical pharmacokinetics	6
A Method for Analysis of Free and Total Ropivacaine in Dog Plasma Using UHPLC–MS/MS	6
Comparative Metabolic Profiling and Anti‐Inflammatory Evaluation of Ceiba speciosa and	6
Identifying of Anticoagulant Ingredients From Moutan Cortex Based on Spectrum‐Effect Relationship Analysis Combined With GRA, PLS, and SVM Algorithms	6
Widely Targeted Metabolomics Reveals the Bioactive Metabolites and Antioxidant Activities of Chinese Yam (Dioscorea opposita Thunb.) Peel	6
Development and Validation of the Novel, Fast Bioanalytical LC‐MS/MS Technique for the Simultaneous Estimation of Sotorasib and Ondansetron: Application to In Vivo Pharmacokinetic Assessments	6
Multiple Reaction Monitoring LC‐MS/MS Quantification of N‐Nitrosamine Drug Substance Related Impurities of Clonidine in Drug Substance and in Tablet Dosage Form	6
Study on the material basis of Zhujing pill in treating fundus lesions through component analysis and network pharmacology	6

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Metabolomics study of the hepatoprotective effect of total flavonoids of Mallotus apelta leaf in carbon tetrachloride‐induced liver fibrosis in rats	6
Screening and characterization of cosmetic efficacy components of Terminalia chebula based on biological activity‐guided methodology	6
Featured Cover	6
Mechanisms exploration of terrestrosin D on pulmonary fibrosis based on plasma metabolomics and network pharmacology	6
Rapid analysis of components in Qizhiweitong tablets and plasma after oral administration in rats by UPLC–Q‐TOF–MS/MS based on a self‐developed database	6
Noval Selective Ligand‐Extraction of Bioactive Components in Complex Natural Products Applying Immobilized Multi‐Target Magnetic Beads	6
Detection of Pesticide Residues in Fruits and Vegetables Involving Different Chromatographic Techniques (LC–MS/MS, GC–MS/MS, GC and HPLC)	6
The Continued Mismeasurement of Plasma Serotonin: A Systematic Review	6
Study on Quality Evaluation of Processed Cimicifuga Rhizoma Based on UPLC Fingerprint and Chemometrics	6
Innovative UPLC technique for concurrent quantification of etofenamate and benzyl nicotinate in the presence of methylparaben and benzyl alcohol in their topical cream: Greens, white, and Six Sigma me	6
Simultaneous quantification of icaritin and its novel 3‐methylcarbamate prodrug in rat plasma using HPLC–MS/MS and its application to pharmacokinetic study	6
Metabolomic analysis of the sera of patients with the long‐term inhalation of caffeine‐sodium benzoate using LC–MS	6
Residue levels, household processing evolution, and risk assessment of chlorothalonil, SDS‐3701, metalaxyl, and dimethomorph in Dendrobium officinale Kimura et Migo	5
Research Progress on the Material Basis of Traditional Chinese Medicines Based on Chemical Biology Methods	5
Issue Information	5
Superior In Vivo Efficacy of Fermented Over Aqueous Astragalus membranaceus in Diabetic Nephropathy: A Systematic Pharmacological Evaluation and Mechanis	5
Exploring Potential Targets and Pathways of Toxicity Attenuation Through Serum Pharmacochemistry and Network Pharmacology in the Processing of Aconiti Lateralis Radix Praeparata	5
Anti‐rheumatoid arthritis effects of Xanthii Fructus by affecting the PI3K‐AKT signaling pathway based on TMT‐labeled quantitative proteomics	5
Exploring Active Ingredients of Hepatoprotective Effect of Raw and Stir‐Baked Gardeniae Fructus Based on Spectrum–Effect Relationship Analysis	5
Development, evaluation of critical method variables and stability assessment using a Box–Behnken design for the determination of organic impurities in a pharmaceutical dosage form of a centrally acti	5
Pharmacokinetics and bioequivalence studies of fluvoxamine maleate tablets in healthy Chinese subjects	5
Integrated pharmacokinetics of Huangqi Jianzhong Tang in normal and chronic atrophic gastritis rats	5
Urinary excretion of silibinin diastereoisomers and their conjugated metabolites in rat and human at different dosages	5
Protective effects of Typhonii Rhizoma in rheumatoid arthritis rats revealed by integrated metabolomics and network pharmacology	5
Development of Mobile‐Phase Buffers and Evaluation of Analytical Performance for HbA_1c Assays	5
Correction to “A LC–MS/MS Method for the Simultaneous Determination of 6‐Cyanodopamine, 6‐Nitrodopamine, 6‐Nitrodopa, 6‐Nitroadrenaline and 6‐Bromodopamine in Human Plasma and Its Clinical Application	5
Bioanalytical Tandem Mass Spectrometry Method for Precise Measurement of Tranexamic Acid in Human Plasma With Unveiling Methodological Advancement: Green Assessment With Advanced Metrics	5
In vivo and in vitro chemical composition and biological activity of traditional vs. dispensing granule decoctions of Coptidis Rhizoma: A comparative study	5
Unraveling the Material Basis of Compound Nanxing Zhitong Plaster: A Multimodal Study Combining Chemical Analysis, Network Pharmacology, and Transdermal Pharmacokinetics	5
Mechanism of Jinteng Qingbi granules in the treatment of rheumatoid arthritis using metabolomics analysis	5
Development and validation of a liquid chromatography coupled with tandem mass spectrometry method for determining total and unbound pamiparib in human plasma and brain tumors	5
Determination by UHPLC‐QTOF‐HRMS of Phosphatidylethanol (PEth) in Dried Blood Spots: Method Validation and Practical Application of a Rising Alcohol Abuse Biomarker With Minimally Invasive Sampling	5
Preparation of amentoflavone‐loaded DSPE‐PEG₂₀₀₀ micelles with improved bioavailability and in vitro antitumor efficacy	5
Trace‐level determination of potential genotoxic impurities in quetiapine fumarate using LC–MS	5
In Silico Assessment and Quantitative Estimation of Potential Toxic Impurities From Propafenone (PFN) Through Generic Route and Using UPLC‐MS/MS Technique	5
Revealing the mechanism of Gualou–Xiebai against myocardial ischemia based on network pharmacology and energy metabolism strategies	5
Analysis of omarigliptin forced degradation products by ultra‐fast liquid chromatography, mass spectrometry, and in vitro toxicity assay	5
Issue Information	5
Assessment of metabolic stability and pharmacokinetics by LC–MS/MS and establishment of the safe dose of IMID‐2, a novel anticancer molecule under drug discovery	5
Investigation Into the Chemical Constituents and Cytotoxic Effects on Lung Cancer Cells of the Rhizomes of Polygonum bistorta L. and Polygonum paleaceum Wall.	5
From Chemical Discrepancy to Mechanistic Insight: UPLC‐MS, Bioinformatics, and In Vivo Studies on the Anti‐Brain Aging Effects of Polygalae Radix and Its Processed Products	5
Bone and periosteum protein analysis via tandem mass tag quantitative proteomics in pediatric patients with osteomyelitis	5
Elucidating the mechanisms underlying the anti‐hyperlipidemic effects of Laportea bulbifera using integrated serum metabolomics and network pharmacology	5
Fluorescent immunochromatography of vancomycin in plasma: A rapid and sensitive quantitative analysis	5
Quantification of Trans‐ and Cis‐Vitamin K1 Isomers in Human Plasma by a Rapid and Sensitive LC–MS/MS Method With Surrogate Matrix	5
An assessment of the antihyperlipidemic ingredients of Qi Ge Decoction based on metabolomics combined with serum pharmacochemistry	5
Advances in Analytical Strategies for Precise Quantification of Topoisomerase Inhibitors: Current Trends and Future Directions	5
Preparation, characterization, and pharmacokinetics of oridonin‐loaded liposomes	5
Jiedu Tongluo Tiaogan Formula Modulates Glycolipid Metabolism in Type 2 Diabetes via Pyroptosis: Network Pharmacology and In Vivo Analysis	5
LC–HRMS methods for the quantification of two artemisinin drugs and their metabolites in rat blood and plasma	5
Retention behaviour of analytes in reversed‐phase high‐performance liquid chromatography—A review	5
Non‐Targeted Metabolomics Analysis of Metabolite Differences in Inocutis tamaricis Under Different Culture Conditions	5
Metabolism of four novel structural analogs of ketamine, 2‐FXE [2‐(ethylamino)‐2‐(2‐fluorophenyl) cyclohexan‐1‐one], 2‐MDCK [2‐(methylamino)‐2‐(o‐tolyl) cyclohexan‐1‐one], 3‐DMXE [2‐(ethylamino	5
A simple and sensitive liquid chromatography triple quadrupole mass spectrometry method for the determination of XL092 in monkey plasma and its application to pharmacokinetic study	5
Determination of six core components from Mahuang Xuanfei Zhike syrup in rat plasma and tissues by UPLC–MS/MS: Application to a pharmacokinetics and tissue distribution study	5
A validated stability‐indicating reversed‐phase‐UPLC method for simultaneous estimation of promethazine hydrochloride, methylparaben, propylparaben and sodium benzoate assay of cough suppressant and a	5
Spectrum‐Effect Relationship Between Fingerprints and Anti‐Inflammatory and Antitussive Activities of Raw and Processed Mume Fructus Extracts	5
Highly sensitive liquid chromatography–mass spectrometry method for the quantitative analysis of mometasone furoate in human plasma: Method validation and application to clinical pharmacokinetic studi	5
Validated HPLC‐UV Detection Method for Cefiderocol Quantification in a Critical Patient Receiving Fetcroja and Treated With Extracorporeal Replacement Therapies	4
Quantification of 3‐bromopyruvate in rat plasma by HPLC–MS/MS employing precolumn derivatization and the application to a pharmacokinetics study	4
Stability‐indicating liquid chromatography method development for assay and impurity profiling of amitriptyline hydrochloride in tablet dosage form and forced degradation study	4
Development and Validation of an RP‐HPLC Method for Organic Impurity Profiling in Baclofen Utilizing Robustness Through a Quality‐by‐Design (QbD) Approach: A Comprehensive Forced Degradation Assessmen	4
Integrated UHPLC‐Q‐TOF‐MS Technology and Network Pharmacology Exploring the Pharmacodynamic Material Basis and Mechanism of Zhi‐Zi‐Hou‐Po Granule for Treatment of Depression–Anxiety Comorbidity	4
A green approach for the analysis of emtricitabine bictegravir and tenofovir in a pharmaceutical preparation using novel HPLC and spectrophotometric methods	4
Establishing a multi‐method approach for unprecedented detection and quantification of 13 genotoxic impurities (GTIs) in Apixaban drug substance through ultra‐performance liquid chromatography (UPLC)	4
Bioanalytical methods for pharmacokinetic studies of antileishmanial drugs	4
Optimizing Mirabegron Stability in Human Plasma: Method Development, Validation Through Integration of Esterase Inhibitors and Stabilizers	4
Urine metabolomic characteristics of female patients with occupational chronic cadmium poisoning after 15 years of treatment	4
Issue Information	4
Sorption and mobility assessment of tembotrione in soils of upper, trans and middle Gangetic plain zones of India	4
A New, Fast, and Sensitive UPLC‐ESI‐MS/MS Method for the Simultaneous Analysis of 13 Neurotransmitters in Rat Brain	4
Comparison of the Antioxidant Capacity of Cell Wall‐Broken Decoction Pieces and Traditional Decoction Pieces of Astragli Radix Based on HPLC‐ABTS Analytical Method	4
A comparative metabolomics study on dried and processed Rehmannia Radix	4
HPLC‐MS/MS Method for the Simultaneous Quantification of SGLT2 Inhibitor YWS22026 and Its M3 Metabolite in Rat Plasma, With Application to Toxicokinetic Study	4
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Therapeutic drug monitoring of free vancomycin concentration in practice: A new analytical technique based on the HFCF–UF sample separation method	4
Study on the Relationship Between HPLC Fingerprint Profiles and Anti‐Inflammatory Activity of Clinopodii Herba	4
Olanzapine‐induced weight gain and lipid dysfunction in mice between different gender	4
Analysis of blood concentrations and clinical application of risdiplam in patients with spinal muscular atrophy using ultra‐high performance liquid chromatography–tandem mass spectrometry	4
Integrated Characterization and Pharmacokinetics of Kanli Granule in Rats Based on UPLC‐Q‐TOF‐MS/MS: In Vitro and In Vivo Component Screening	4
Development and validation of LC–MS/MS methods for the simultaneous quantification of sofosbuvir and its major metabolite (GS‐331007) in blood plasma and cerebrospinal and seminal fluid: Application t	4
Serum metabolic profile evidence for relationship between schizophrenia and depression: An untargeted metabolomics	4
Preclinical pharmacokinetics and metabolism study of SCO‐267, a GPR40 full agonist, in beagle dogs using ultra‐high performance liquid chromatography coupled to tandem mass spectrometry	4
Issue Information	4
Identification and Verification of the Anti‐Insomnia Compounds From Herbal Pair Albiziae Cortex and Polygoni Multiflori Caulis Using Immobilized 5‐HT _1A	4
Identification and Multidimensional Evaluation of Quality Markers in Yupingfeng via UPLC‐Q‐Orbitrap‐MS, Network Pharmacology, UPLC‐UV Fingerprint, and UPLC‐QQQ‐MS	4
Integrating Metabolomics and Serum Pharmacochemistry to Reveal Potential Hemostatic Components and Processing Mechanisms of Carbonized Typhae Pollen	4
A Simultaneous Determination of 14 Chemical Compounds From Rubi Fructus in Rat Plasma by UHPLC‐QTR	4
Determination of valproic acid and its six metabolites in human serum using LC–MS/MS and application to interaction with carbapenems in epileptic patients	4
Comprehensive Proteomic and Metabolomic Analysis of Novel Substituted Fluoroquinolone Derivatives in Escherichia coli	4
Research progress in the application of proteomics technology in brain injury	4
Advances in mass spectrometry for metabolomics: Strategies, challenges, and innovations in disease biomarker discovery	4
Optimization of a HPLC–UV bioanalytical method using Box–Behnken design to determine the oral pharmacokinetics of neratinib maleate in Wistar rats	4
Analytical method for urinary homovanillic acid and 5‐hydroxyindoleacetic acid levels using HPLC with electrochemical detection applied to evaluate children environmentally exposed to manganese	4