BioEssays

Article	Citations
DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis	108
The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin	67
From structure to function: Route to understanding lncRNA mechanism	62
Interoception and the origin of feelings: A new synthesis	61
Paraspeckle nuclear condensates: Global sensors of cell stress?	58
Cancer as a prospective sequela of long COVID‐19	55
Cancer progression as a sequence of atavistic reversions	49
Bridging the explanatory gaps: What can we learn from a biological agency perspective?	48
mTORC1 and ferroptosis: Regulatory mechanisms and therapeutic potential	44
Reconciling the seemingly irreconcilable: The WHO's ICF system integrates biological and psychosocial environmental determinants of autism and ADHD	43
Superposition of COVID‐19 waves, anticipating a sustained wave, and lessons for the future	43
DNA adenine methylation in eukaryotes: Enzymatic mark or a form of DNA damage?	40
Noncanonical functions of the serine‐arginine‐rich splicing factor (SR) family of proteins in development and disease	39
Single cell RNA‐sequencing: A powerful yet still challenging technology to study cellular heterogeneity	38
Tumor necrosis: A synergistic consequence of metabolic stress and inflammation	37
BRD4 in physiology and pathology: ‘‘BET’’ on its partners	36
Transmissible cancers in mammals and bivalves: How many examples are there?	34
Accounting for variation in and overuse of antibiotics among humans	33
Epigenetic editing: Dissecting chromatin function in context	33
Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment	32
A second Warburg‐like effect in cancer metabolism: The metabolic shift of glutamine‐derived nitrogen	30
How everyday sounds can trigger strong emotions: ASMR, misophonia and the feeling of wellbeing	30
Phage lysis‐lysogeny switches and programmed cell death: Danse macabre	26
Metabolomics meets lipidomics: Assessing the small molecule component of metabolism	25
Pushing Raman spectroscopy over the edge: purported signatures of organic molecules in fossil animals are instrumental artefacts	25

The chaperone Clusterin in neurodegeneration−friend or foe?	24
Microscopy‐based assay for semi‐quantitative detection of SARS‐CoV‐2 specific antibodies in human sera	23
Positive allometry of sexually selected traits: Do metabolic maintenance costs play an important role?	23
Prime editing in plants and mammalian cells: Mechanism, achievements, limitations, and future prospects	23
Ocean carbon sequestration: Particle fragmentation by copepods as a significant unrecognised factor?	23
Dimensional reduction in complex living systems: Where, why, and how	22
CRISPR/Cas technology as a promising weapon to combat viral infections	22
How to become a crab: Phenotypic constraints on a recurring body plan	22
Processed pseudogenes: A substrate for evolutionary innovation	21
Strangers look sicker (with implications in times of COVID‐19)	21
Methods for enzyme library creation: Which one will you choose?	21
How potassium came to be the dominant biological cation: of metabolism, chemiosmosis, and cation selectivity since the beginnings of life	21
Rebuilding relationships on coral reefs: Coral bleaching knowledge‐sharing to aid adaptation planning for reef users	20
Neural stem cell pools in the vertebrate adult brain: Homeostasis from cell‐autonomous decisions or community rules?	20
COVID‐19 coagulopathies: Human blood proteins mimic SARS‐CoV‐2 virus, vaccine proteins and bacterial co‐infections inducing autoimmunity	19
Host under epigenetic control: A novel perspective on the interaction between microorganisms and corals	19
Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities, and pathophysiological functions	19
Degeneracy in the nervous system: from neuronal excitability to neural coding	19
RNA‐protein interactions: Central players in coordination of regulatory networks	19
The fine‐tuning of cell membrane lipid bilayers accentuates their compositional complexity	19
SARS‐CoV‐2 infection and cancer	19
Gene mutations impede oocyte maturation, fertilization, and early embryonic development	18
The enigmatic Placozoa part 1: Exploring evolutionary controversies and poor ecological knowledge	18
How immune‐cell fate and function are determined by metabolic pathway choice	18
How does early‐life adversity shape telomere dynamics during adulthood? Problems and paradigms	18
Circalunar clocks—Old experiments for a new era	18
GWAS for genetics of complex quantitative traits: Genome to pangenome and SNPs to SVs and k‐mers	18
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases	18
Managing enzyme promiscuity in plant specialized metabolism: A lesson from flavonoid biosynthesis	17
Did doubly uniparental inheritance (DUI) of mtDNA originate as a cytoplasmic male sterility (CMS) system?	17
Chromatin behavior in living cells: Lessons from single‐nucleosome imaging and tracking	17
Brain wiring with composite instructions	17
Small mitochondrial RNAs as mediators of nuclear gene regulation, and potential implications for human health	16
SARS‐CoV‐2′s claimed natural origin is undermined by issues with genome sequences of its relative strains	16
TRPV4: A trigger of pathological RhoA activation in neurological disease	16
BTB domains: A structural view of evolution, multimerization, and protein–protein interactions	16
No neonates without adults	16
Designer nanoparticles for plant cell culture systems: Mechanisms of elicitation and harnessing of specialized metabolites	16
The solid tumor microenvironment—Breaking the barrier for T cells	15
How do boreal forest soils store carbon?	15
SNP‐based heritability and selection analyses: Improved models and new results	15
Beyond genotype‐phenotype maps: Toward a phenotype‐centered perspective on evolution	15
Physiological mediators of prenatal environmental influences in autism spectrum disorder	15
Sorting of cargo in the tubular endosomal network	15
Solving the conundrum of intra‐specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit	14
Soft repression: Subtle transcriptional regulation with global impact	14
Bone regeneration via skeletal cell lineage plasticity: All hands mobilized for emergencies	14
CRISPR/Cas9: A new tool for the study and control of helminth parasites	14
Revisiting poly(A)‐binding proteins: Multifaceted regulators during gametogenesis and early embryogenesis	14
Cancer's second genome: Microbial cancer diagnostics and redefining clonal evolution as a multispecies process	14

Function moves biomolecular condensates in phase space	13
Teeth reveal juvenile diet, health and neurotoxicant exposure retrospectively: What biological rhythms and chemical records tell us	13
Males can adjust offspring sex ratio in an adaptive fashion through different mechanisms	13
Is mitochondrial reactive oxygen species production proportional to oxygen consumption? A theoretical consideration	13
New tools suggest a middle Jurassic origin for mammalian endothermy	13
“Minimal metabolism”: A key concept to investigate the origins and nature of biological systems	13
Trade‐offs between the instantaneous growth rate and long‐term fitness: Consequences for microbial physiology and predictive computational models	13
Reactive oxygen species (ROS) constitute an additional player in regulating epithelial development	13
The glow of the night: The tapetum lucidum as a co‐adaptation for the inverted retina	13
The SARS‐CoV‐2 origin dilemma: Zoonotic transfer or laboratory leak?	13
Air pollution and cardiovascular disease: Can the Australian bushfires and global COVID‐19 pandemic of 2020 convince us to change our ways?	13
Molecular dynamics studies reveal structural and functional features of the SARS‐CoV‐2 spike protein	12
The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms	12
Challenging endings: How telomeres prevent fragility	12
Mammalian D‐cysteine: A novel regulator of neural progenitor cell proliferation	12
Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles	12
Paneth cells: Maintaining dynamic microbiome‐host homeostasis, protecting against inflammation and cancer	12
Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals	12
The cell cycle and differentiation as integrated processes: Cyclins and CDKs reciprocally regulate Sox and Notch to balance stem cell maintenance	12
Endothelial ontogeny and the establishment of vascular heterogeneity	12
Epigenetic rejuvenation by partial reprogramming	12
Apoptotic mitochondrial poration by a growing list of pore‐forming BCL‐2 family proteins	11
Structural basis of the conformational and functional regulation of human SERCA2b, the ubiquitous endoplasmic reticulum calcium pump	11
Endolysosomal cholesterol export: More than just NPC1	11
DNA replication timing: Biochemical mechanisms and biological significance	11
Can BCG vaccine protect against COVID‐19 via trained immunity and tolerogenesis?	11
Fine‐tuning ER‐phagy by post‐translational modifications	11
The strange case of Drp1 in autophagy: Jekyll and Hyde?	11
How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?	11
Broad H3K4me3 domains: Maintaining cellular identity and their implication in super‐enhancer hijacking	11
Population modification strategies for malaria vector control are uniquely resilient to observed levels of gene drive resistance alleles	11
Taming fitness: Organism‐environment interdependencies preclude long‐term fitness forecasting	11
CBC‐Clock Theory of Life – Integration of cellular circadian clocks and cellular sentience is essential for cognitive basis of life	11
Cell growth and the cell cycle: New insights about persistent questions	11
Global climate change, diet, and the complex relationship between human host and microbiome: Towards an integrated picture	11
Post‐translational Wnt receptor regulation: Is the fog slowly clearing?	11
The promises of lysine polyphosphorylation as a regulatory modification in mammals are tempered by conceptual and technical challenges	11
Metabolism and chromatin: A dynamic duo that regulates development and ageing	11
The CAR group of Ig cell adhesion proteins–Regulators of gap junctions?	11
Importin α/β and the tug of war to keep TDP‐43 in solution: quo vadis?	10
Location bias: A “Hidden Variable” in GPCR pharmacology	10
Beyond the GTP‐cap: Elucidating the molecular mechanisms of microtubule catastrophe	10
The gamma‐tubulin ring complex: Deciphering the molecular organization and assembly mechanism of a major vertebrate microtubule nucleator	10
Collective cell migration driven by filopodia—New insights from the social behavior of myotubes	10
Biological sex is binary, even though there is a rainbow of sex roles	10
Molecules interact. But how strong and how much?	10
Tolerogenic and immunogenic states of Langerhans cells are orchestrated by epidermal signals acting on a core maturation gene module	10
Estrogen receptor α revised: Expression, structure, function, and stability	10
Rho GTPases: Non‐canonical regulation by cysteine oxidation	10
The tyranny of phylogeny—A plea for a less dogmatic stance on two‐species comparisons	10
Evaluation of 92 cardiovascular proteins in dried blood spots collected under field‐conditions	10
Rebirth of the translational machinery: The importance of recycling ribosomes	10
Modeling the evolution of interconnected processes: It is the song and the singers	10
NIPSNAP protein family emerges as a sensor of mitochondrial health	10
Switching DCAFs: Beyond substrate receptors	10
The PINK1 repertoire: Not just a one trick pony	10
Genotoxic stress response: What is the role of cytoplasmic mRNA fate?	9
Do some viruses use growth hormone, prolactin and their receptors to facilitate entry into cells?	9
Evolutionary context can clarify gene names: Teleosts as a case study	9
Eomes and T‐bet, a dynamic duo regulating NK cell differentiation	9
Why do cancer cells break from host circadian rhythm? Insights from unicellular organisms	9
MiRNAs in early brain development and pediatric cancer	9
The tree of life describes a tripartite cellular world	9
Neuron‐glia crosstalk in neuronal remodeling and degeneration: Neuronal signals inducing glial cell phagocytic transformation in Drosophila	9
Desynchronized circadian clock and exposures to xenobiotics are associated with differentiated disease phenotypes	9
Inheritance and maintenance of small RNA‐mediated epigenetic effects	9
Unexpected new insights into DNA clamp loaders	9
Skin aging: Dermal adipocytes metabolically reprogram dermal fibroblasts	9
Muscle stem cells get a new look: Dynamic cellular projections as sensors of the stem cell niche	9
Active genetics comes alive	8
Personalized health and the coronavirus vaccines—Do individual genetics matter?	8
Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative disease	8
Longitudinal observations call into question the scientific consensus that humans are unaffected by lunar cycles	8
Ribosomal protein uS3 in cell biology and human disease: Latest insights and prospects	8
Do microenvironmental changes disrupt multicellular organisation with ageing, enacting and favouring the cancer cell phenotype?	8
Regulation and function of poised mRNAs in lymphocytes	8
Modulation of H3.3 chromatin assembly by PML: A way to regulate epigenetic inheritance	8
Co‐translational folding of nascent polypeptides: Multi‐layered mechanisms for the efficient biogenesis of functional proteins	8
Cancer and the breakdown of multicellularity: What Dictyostelium discoideum, a social amoeba, can teach us	8
Skipping sex: A nonrecombinant genomic assemblage of complementary reproductive modules	8

Raman spectroscopy is a powerful tool in molecular paleobiology: An analytical response to Alleon et al. (https://doi.org/10.1002/bies.202000295)	8
Foraminifera as a model of the extensive variability in genome dynamics among eukaryotes	8
The cap epitranscriptome: Early directions to a complex life as mRNA	8
Does transcriptional heterogeneity facilitate the development of genetic drug resistance?	8
GC‐content biases in protein‐coding genes act as an “mRNA identity” feature for nuclear export	8
Perirhinal cortex area 35 controls the functional link between the perirhinal and entorhinal‐hippocampal circuitry	8
Bayes and Darwin: How replicator populations implement Bayesian computations	8
Nucleosomes and flipons exchange energy to alter chromatin conformation, the readout of genomic information, and cell fate	8
Concerted evolution of ribosomal DNA: Somatic peace amid germinal strife	8
Embryonic movement stimulates joint formation and development: Implications in arthrogryposis multiplex congenita	8
Minichromosome maintenance proteins in eukaryotic chromosome segregation	8
Disruption of regulatory domains and novel transcripts as disease‐causing mechanisms	8
From correlation to causation: The new frontier of transgenerational epigenetic inheritance	7
The XK plasma membrane scramblase and the VPS13A cytosolic lipid transporter for ATP‐induced cell death	7
A second chance for protein targeting/folding: Ubiquitination and deubiquitination of nascent proteins	7
Can aggressive cancers be identified by the “aggressiveness” of their chromatin?	7
A Kuhnian revolution in molecular biology: Most genes in complex organisms express regulatory RNAs	7
Cytoskeletal diversification across 1 billion years: What red algae can teach us about the cytoskeleton, and vice versa	7
Do seasonal microbiome changes affect infection susceptibility, contributing to seasonal disease outbreaks?	7
Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology	7
Controlling contacts—Molecular mechanisms to regulate organelle membrane tethering	7
Using primary teeth and archived dried spots for exposomic studies in children: Exploring new paths in the environmental epidemiology of pediatric cancer	7
Liquid–liquid phase separation drives the β‐catenin destruction complex formation	7
Endosymbiotic ratchet accelerates divergence after organelle origin	7
Flipping and other astonishing transporter dance moves in fungal drug resistance	7
SAC during early cell divisions: Sacrificing fidelity over timely division, regulated differently across organisms	7
Fatty acids may influence insulin dynamics through modulation of albumin‐Zn2+ interactions	7
Prolactin as an adrenocorticotropic hormone: Prolactin signalling is a conserved key regulator of sexually dimorphic adrenal gland function in health and disease	7
Keeping the balance: The noncoding RNA 7SK as a master regulator for neuron development and function	7
Physical ‘strength’ of the multi‐protein chain connecting immune cells: Does the weakest link limit antibody affinity maturation?	7
Watching the embryo: Evolution of the microscope for the study of embryogenesis	7
MicroRNAs play regulatory roles in genomic balance	7
Functional interplay within the epitranscriptome: Reality or fiction?	7
Oxiforms: Unique cysteine residue‐ and chemotype‐specified chemical combinations can produce functionally‐distinct proteoforms	7
Electrical signalling in prokaryotes and its convergence with quorum sensing in Bacillus	6
Coming into clear sight at last: Ancestral and derived events during chelicerate visual system development	6
Mitotic poleward flux: Finding balance between microtubule dynamics and sliding	6
The current status and trends of DNA extraction	6
Why does COVID‐19 pathology have several clinical forms?	6
Aster la vista: Unraveling the biochemical basis of carotenoid homeostasis in the human retina	6
Mitochondrial Russian doll genes may explain some discrepancies in links between mtDNA mutations and mitochondrial diseases	6
Flagellar export apparatus and ATP synthetase: Homology evidenced by synteny predating the Last Universal Common Ancestor	6
Modern cities modelled as “super‐cells” rather than multicellular organisms: Implications for industry, goods and services	6
Evolutionary physiology at 30+: Has the promise been fulfilled?	6
The axonal radial contractility: Structural basis underlying a new form of neural plasticity	6
The circle of Willis revisited: Forebrain dehydration sensing facilitated by the anterior communicating artery	6
A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution	6
Sequestering the 5′‐cap for viral RNA packaging	6
Models for human porphyrias: Have animals in the wild been overlooked?	6
Assay technologies facilitating drug discovery for ADP‐ribosyl writers, readers and erasers	6
Hanging the coat on a collar: Same function but different localization and mechanism for COPII	6
Neddylation‐CRLs regulate the functions of Treg immune cells	6
The 4E approach to the human microbiome: Nested interactions between the gut‐brain/body system within natural and built environments	6
Transcription‐independent functions of p53 in DNA repair pathway selection	6
Amphibian regeneration and mammalian cancer: Similarities and contrasts from an evolutionary biology perspective	6
Why PGD2 has different functions from PGE2	6
How germline genes promote malignancy in cancer cells	6
ISG15: A link between innate immune signaling, DNA replication, and genome stability	6
Ascorbic acid modulates immune responses through Jumonji‐C domain containing histone demethylases and Ten eleven translocation (TET) methylcytosine dioxygenase	6
There is no evidence of SARS‐CoV‐2 laboratory origin: Response to Segreto and Deigin (DOI: 10.1002/bies.202000240)	6
Network architecture and sex chromosome turnovers	6
Proteolytic control in ciliogenesis: Temporal restriction or early initiation?	6
Can natural selection and druggable targets synergize? Of nutrient scarcity, cancer, and the evolution of cooperation	6
Paradigm shifts in animal epigenetics: Research on non‐model species leads to new insights into dependencies, functions and inheritance of DNA methylation	6
Fluid protein fold space and its implications	6
Potential of the CRISPR‐Cas system for improved parasite diagnosis	6
How signaling pathways link extracellular mechano‐environment to proline biosynthesis: A hypothesis	5
Are endoplasmic reticulum subdomains shaped by asymmetric distribution of phospholipids? Evidence from a C. elegans model system	5
The renin‐angiotensin system in COVID‐19: Why ACE2 targeting by coronaviruses produces higher mortality in elderly hypertensive patients?	5
Cell population‐based framework of genetic epidemiology in the single‐cell omics era	5
Defining bone fide effectors of RAS GTPases	5
Conformational flexibility of β‐arrestins – How these scaffolding proteins guide and transform the functionality of GPCRs	5
Trans‐synaptic mechanisms orchestrated by mammalian synaptic cell adhesion molecules	5
The art of molecular computing: Whence and whither	5
Cytoplasmic mRNPs revisited: Singletons and condensates	5
Tubulin deacetylase NDST3 modulates lysosomal acidification: Implications in neurological diseases	5
The changing chromatome as a driver of disease: A panoramic view from different methodologies	5
A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?	5
The enigmatic Placozoa part 2: Exploring evolutionary controversies and promising questions on earth and in space	5
The power of the (imperfect) palindrome: Sequence‐specific roles of palindromic motifs in gene regulation	5
Keeping intracellular DNA untangled: A new role for condensin?	5
Promoters are key organizers of the duplication of vertebrate genomes	5
Benefits of co‐translational complex assembly for cellular fitness	5
Transcription factors regulate early T cell development via redeployment of other factors	5
Functional hierarchy of PCNA‐interacting motifs in DNA processing enzymes	5
The dynamic role of cohesin in maintaining human genome architecture	5
Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes	5
An emerging role of transcription in chromosome segregation: Ongoing centromeric transcription maintains centromeric cohesion	5
Fighting microbial pathogens by integrating host ecosystem interactions and evolution	5
Evo‐devo beyond development: Generalizing evo‐devo to all levels of the phenotypic evolution	5
Ancient Darwinian replicators nested within eubacterial genomes	5
Molecular characteristics of the multi‐functional FAO enzyme ACAD9 illustrate the importance of FADH2/NADH ratios for mitochondrial ROS formation	5
Restriction of intraflagellar transport to some microtubule doublets: An opportunity for cilia diversification?	5
An oncospace for human cancers	5
Druggable differences: Targeting mechanistic differences between trans‐translation and translation for selective antibiotic action	5