BioEssays

Article	Citations
Spatially Resolved Transcriptomes—Next Generation Tools for Tissue Exploration	314
YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy	144
Adapting with Microbial Help: Microbiome Flexibility Facilitates Rapid Responses to Environmental Change	137
DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis	83
Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)	75
The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin	62
Crosstalk between Cell Adhesion Complexes in Regulation of Mechanotransduction	61
Ghost Introgression: Spooky Gene Flow in the Distant Past	55
Mechanical and Non‐Mechanical Functions of Filamentous and Non‐Filamentous Vimentin	51
Beta‐Adrenergic Blockers as a Potential Treatment for COVID‐19 Patients	51
From structure to function: Route to understanding lncRNA mechanism	45
Cancer as a prospective sequela of long COVID‐19	44
Monitoring Autophagy Flux and Activity: Principles and Applications	43
Eustress and Distress: Neither Good Nor Bad, but Rather the Same?	43
Paraspeckle nuclear condensates: Global sensors of cell stress?	42
Interoception and the origin of feelings: A new synthesis	42
Superposition of COVID‐19 waves, anticipating a sustained wave, and lessons for the future	40
Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions	39
Bridging the explanatory gaps: What can we learn from a biological agency perspective?	38
Trehalose against Alzheimer's Disease: Insights into a Potential Therapy	37
Cancer progression as a sequence of atavistic reversions	35
Noncanonical functions of the serine‐arginine‐rich splicing factor (SR) family of proteins in development and disease	32
Age and Location in Severity of COVID‐19 Pathology: Do Lactoferrin and Pneumococcal Vaccination Explain Low Infant Mortality and Regional Differences?	32
Present‐Day DNA Contamination in Ancient DNA Datasets	31
mTORC1 and ferroptosis: Regulatory mechanisms and therapeutic potential	31

Ubiquitin‐Modulated Phase Separation of Shuttle Proteins: Does Condensate Formation Promote Protein Degradation?	31
Scale‐Free Biology: Integrating Evolutionary and Developmental Thinking	31
DNA adenine methylation in eukaryotes: Enzymatic mark or a form of DNA damage?	30
Reconciling the seemingly irreconcilable: The WHO's ICF system integrates biological and psychosocial environmental determinants of autism and ADHD	30
Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever	29
Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment	28
Biogenic Iron Preserves Structures during Fossilization: A Hypothesis	28
The Mechanical Role of Microtubules in Tissue Remodeling	28
BRD4 in physiology and pathology: ‘‘BET’’ on its partners	28
Mitochondrial Dysfunction in Schizophrenia	27
Accounting for variation in and overuse of antibiotics among humans	26
Commensal Rats and Humans: Integrating Rodent Phylogeography and Zooarchaeology to Highlight Connections between Human Societies	26
Neuronal Compartmentalization: A Means to Integrate Sensory Input at the Earliest Stage of Information Processing?	25
Temperature‐Dependent Sex Determination in Sea Turtles in the Context of Climate Change: Uncovering the Adaptive Significance	24
Transmissible cancers in mammals and bivalves: How many examples are there?	24
Lifespan Extension Via Dietary Restriction: Time to Reconsider the Evolutionary Mechanisms?	24
How everyday sounds can trigger strong emotions: ASMR, misophonia and the feeling of wellbeing	24
Tumor necrosis: A synergistic consequence of metabolic stress and inflammation	23
A second Warburg‐like effect in cancer metabolism: The metabolic shift of glutamine‐derived nitrogen	23
Single cell RNA‐sequencing: A powerful yet still challenging technology to study cellular heterogeneity	23
Phage lysis‐lysogeny switches and programmed cell death: Danse macabre	23
Metabolomics meets lipidomics: Assessing the small molecule component of metabolism	23
Introducing the 21st Century's New Four Horsemen of the Coronapocalypse	23
Pushing Raman spectroscopy over the edge: purported signatures of organic molecules in fossil animals are instrumental artefacts	22
Might SARS‐CoV‐2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?	21
Strangers look sicker (with implications in times of COVID‐19)	21
Genetic Causation in Complex Regulatory Systems: An Integrative Dynamic Perspective	21
Competitive and Coordinative Interactions between Body Parts Produce Adaptive Developmental Outcomes	20
Understanding Human Lung Development through In Vitro Model Systems	20
Positive allometry of sexually selected traits: Do metabolic maintenance costs play an important role?	20
Polycomb Repressive Complexes in Hox Gene Regulation: Silencing and Beyond	20
CRISPR/Cas technology as a promising weapon to combat viral infections	20
Epigenetic editing: Dissecting chromatin function in context	20
Evolution of Sex Determination and Sex Chromosomes: A Novel Alternative Paradigm	19
Microscopy‐based assay for semi‐quantitative detection of SARS‐CoV‐2 specific antibodies in human sera	19
Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation	19
How to become a crab: Phenotypic constraints on a recurring body plan	18
How potassium came to be the dominant biological cation: of metabolism, chemiosmosis, and cation selectivity since the beginnings of life	18
How immune‐cell fate and function are determined by metabolic pathway choice	18
Developmental Transcriptional Enhancers: A Subtle Interplay between Accessibility and Activity	18
Methods for enzyme library creation: Which one will you choose?	18
Sequencing Strategies for Fusion Gene Detection	18
The chaperone Clusterin in neurodegeneration−friend or foe?	17
Ocean carbon sequestration: Particle fragmentation by copepods as a significant unrecognised factor?	17
SARS‐CoV‐2 infection and cancer	17
RNA‐protein interactions: Central players in coordination of regulatory networks	17
Processed pseudogenes: A substrate for evolutionary innovation	17
Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities, and pathophysiological functions	17
Prime editing in plants and mammalian cells: Mechanism, achievements, limitations, and future prospects	17
Evolution of Sex Determination in Amniotes: Did Stress and Sequential Hermaphroditism Produce Environmental Determination?	16

Did Acidic Stress Resistance in Vertebrates Evolve as Na+/H+ Exchanger‐Mediated Ammonia Excretion in Fish?	16
Brain wiring with composite instructions	16
Peptidylprolylisomerases, Protein Folders, or Scaffolders? The Example of FKBP51 and FKBP52	16
Neural stem cell pools in the vertebrate adult brain: Homeostasis from cell‐autonomous decisions or community rules?	16
Dimensional reduction in complex living systems: Where, why, and how	16
Host under epigenetic control: A novel perspective on the interaction between microorganisms and corals	15
GWAS for genetics of complex quantitative traits: Genome to pangenome and SNPs to SVs and k‐mers	15
The fine‐tuning of cell membrane lipid bilayers accentuates their compositional complexity	15
Speculating on the Roles of Nuclear Speckles: How RNA‐Protein Nuclear Assemblies Affect Gene Expression	15
SARS‐CoV‐2′s claimed natural origin is undermined by issues with genome sequences of its relative strains	15
Gene mutations impede oocyte maturation, fertilization, and early embryonic development	15
COVID‐19 coagulopathies: Human blood proteins mimic SARS‐CoV‐2 virus, vaccine proteins and bacterial co‐infections inducing autoimmunity	14
Chromatin behavior in living cells: Lessons from single‐nucleosome imaging and tracking	14
The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time	14
SNP‐based heritability and selection analyses: Improved models and new results	14
The enigmatic Placozoa part 1: Exploring evolutionary controversies and poor ecological knowledge	14
Circalunar clocks—Old experiments for a new era	14
Revisiting poly(A)‐binding proteins: Multifaceted regulators during gametogenesis and early embryogenesis	14
Rebuilding relationships on coral reefs: Coral bleaching knowledge‐sharing to aid adaptation planning for reef users	14
Soft repression: Subtle transcriptional regulation with global impact	13
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases	13
Degeneracy in the nervous system: from neuronal excitability to neural coding	13
How does early‐life adversity shape telomere dynamics during adulthood? Problems and paradigms	13
Bone regeneration via skeletal cell lineage plasticity: All hands mobilized for emergencies	13
CRISPR/Cas9: A new tool for the study and control of helminth parasites	13
Small mitochondrial RNAs as mediators of nuclear gene regulation, and potential implications for human health	13
Biodynamic Interfaces Are Essential for Human–Environment Interactions	13
Metabolic Reprogramming is a Hallmark of Metabolism Itself	12
Managing enzyme promiscuity in plant specialized metabolism: A lesson from flavonoid biosynthesis	12
The Tissue Clock Network: Driver and Gatekeeper of Circadian Physiology	12
Designer nanoparticles for plant cell culture systems: Mechanisms of elicitation and harnessing of specialized metabolites	12
The Vertebrate Tooth Row: Is It Initiated by a Single Organizing Tooth?	12
The SARS‐CoV‐2 origin dilemma: Zoonotic transfer or laboratory leak?	12
TRPV4: A trigger of pathological RhoA activation in neurological disease	12
Did doubly uniparental inheritance (DUI) of mtDNA originate as a cytoplasmic male sterility (CMS) system?	12
Palmitoylated Proteins in Plasmodium falciparum‐Infected Erythrocytes: Investigation with Click Chemistry and Metabolic Labeling	12
Males can adjust offspring sex ratio in an adaptive fashion through different mechanisms	12
Cancer's second genome: Microbial cancer diagnostics and redefining clonal evolution as a multispecies process	12
Structural Basis of Nucleosome Recognition and Modulation	12
Physiological mediators of prenatal environmental influences in autism spectrum disorder	11
Is mitochondrial reactive oxygen species production proportional to oxygen consumption? A theoretical consideration	11
Rhes Tunnels: A Radical New Way of Communication in the Brain's Striatum?	11
Stress Responses Co‐Opted for Specialized Cell Types During the Early Evolution of Multicellularity	11
“Minimal metabolism”: A key concept to investigate the origins and nature of biological systems	11
Air pollution and cardiovascular disease: Can the Australian bushfires and global COVID‐19 pandemic of 2020 convince us to change our ways?	11
Challenging endings: How telomeres prevent fragility	11
The Fluidity of the Bacterial Outer Membrane Is Species Specific	11
Eggshell Biliverdin as an Antioxidant Maternal Effect	11
Mammalian D‐cysteine: A novel regulator of neural progenitor cell proliferation	11
The complex web of canonical and non‐canonical Hedgehog signaling	10
Endothelial ontogeny and the establishment of vascular heterogeneity	10
Why Is AUG the Start Codon?	10
Paneth cells: Maintaining dynamic microbiome‐host homeostasis, protecting against inflammation and cancer	10
Beyond genotype‐phenotype maps: Toward a phenotype‐centered perspective on evolution	10
Tissue‐disruption‐induced cellular stochasticity and epigenetic drift: Common origins of aging and cancer?	10
The glow of the night: The tapetum lucidum as a co‐adaptation for the inverted retina	10
The solid tumor microenvironment—Breaking the barrier for T cells	10
Solving the conundrum of intra‐specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit	10
Post‐translational Wnt receptor regulation: Is the fog slowly clearing?	10
Taming fitness: Organism‐environment interdependencies preclude long‐term fitness forecasting	10
Metabolism and chromatin: A dynamic duo that regulates development and ageing	10
Structural basis of the conformational and functional regulation of human SERCA2b, the ubiquitous endoplasmic reticulum calcium pump	10
The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms	10
NIPSNAP protein family emerges as a sensor of mitochondrial health	10
Cross‐Generational Effects of Parental Age on Offspring Longevity: Are Telomeres an Important Underlying Mechanism?	10
Why do cancer cells break from host circadian rhythm? Insights from unicellular organisms	9
Endolysosomal cholesterol export: More than just NPC1	9
Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling	9
Population modification strategies for malaria vector control are uniquely resilient to observed levels of gene drive resistance alleles	9
Reactive oxygen species (ROS) constitute an additional player in regulating epithelial development	9
The promises of lysine polyphosphorylation as a regulatory modification in mammals are tempered by conceptual and technical challenges	9
Why the Outcome of Anti‐Tumor Immune Responses is Heterogeneous: A Novel Idea in the Context of Immunological Heterogeneity in Cancers	9
Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles	9
Modeling the evolution of interconnected processes: It is the song and the singers	9
Global climate change, diet, and the complex relationship between human host and microbiome: Towards an integrated picture	9
Rho GTPases: Non‐canonical regulation by cysteine oxidation	9
Lipophilic Environmental Chemical Mixtures Released During Weight‐Loss: The Need to Consider Dynamics	9
MiRNAs in early brain development and pediatric cancer	9
How do boreal forest soils store carbon?	9
The CAR group of Ig cell adhesion proteins–Regulators of gap junctions?	9

New tools suggest a middle Jurassic origin for mammalian endothermy	9
Cas9 Cuts and Consequences; Detecting, Predicting, and Mitigating CRISPR/Cas9 On‐ and Off‐Target Damage	9
Biomarkers for Early Cancer Diagnosis: Prospects for Success through the Lens of Tumor Genetics	9
Repair and Reconstruction of Telomeric and Subtelomeric Regions and Genesis of New Telomeres: Implications for Chromosome Evolution	9
Switching DCAFs: Beyond substrate receptors	9
Can BCG vaccine protect against COVID‐19 via trained immunity and tolerogenesis?	9
The PINK1 repertoire: Not just a one trick pony	9
Fine‐tuning ER‐phagy by post‐translational modifications	9
Tolerogenic and immunogenic states of Langerhans cells are orchestrated by epidermal signals acting on a core maturation gene module	9
The gamma‐tubulin ring complex: Deciphering the molecular organization and assembly mechanism of a major vertebrate microtubule nucleator	8
Do some viruses use growth hormone, prolactin and their receptors to facilitate entry into cells?	8
The tree of life describes a tripartite cellular world	8
Evaluation of 92 cardiovascular proteins in dried blood spots collected under field‐conditions	8
Molecular dynamics studies reveal structural and functional features of the SARS‐CoV‐2 spike protein	8
A Cryptic Alternative for the Evolution of Hyphae	8
Environmental Oxygen is a Key Modulator of Development and Evolution: From Molecules to Ecology	8
The tyranny of phylogeny—A plea for a less dogmatic stance on two‐species comparisons	8
The cell cycle and differentiation as integrated processes: Cyclins and CDKs reciprocally regulate Sox and Notch to balance stem cell maintenance	8
CBC‐Clock Theory of Life – Integration of cellular circadian clocks and cellular sentience is essential for cognitive basis of life	8
Skipping sex: A nonrecombinant genomic assemblage of complementary reproductive modules	8
Evolutionary Views of Tuberculosis: Indoleamine 2,3‐Dioxygenase Catalyzed Nicotinamide Synthesis Reflects Shifts in Macrophage Metabolism	8
Do microenvironmental changes disrupt multicellular organisation with ageing, enacting and favouring the cancer cell phenotype?	8
Active genetics comes alive	8
Cancer and the breakdown of multicellularity: What Dictyostelium discoideum, a social amoeba, can teach us	8
Desynchronized circadian clock and exposures to xenobiotics are associated with differentiated disease phenotypes	8
Importin α/β and the tug of war to keep TDP‐43 in solution: quo vadis?	8
Ribosomal protein uS3 in cell biology and human disease: Latest insights and prospects	7
MicroRNAs play regulatory roles in genomic balance	7
Estrogen receptor α revised: Expression, structure, function, and stability	7
Big Baby, Little Mother: Tsetse Flies Are Exceptions to the Juvenile Small Size Principle	7
Subtelomeres as Specialized Chromatin Domains	7
Neuron‐glia crosstalk in neuronal remodeling and degeneration: Neuronal signals inducing glial cell phagocytic transformation in Drosophila	7
SAC during early cell divisions: Sacrificing fidelity over timely division, regulated differently across organisms	7
BTB domains: A structural view of evolution, multimerization, and protein–protein interactions	7
Genotoxic stress response: What is the role of cytoplasmic mRNA fate?	7
Longitudinal observations call into question the scientific consensus that humans are unaffected by lunar cycles	7
Trade‐offs between the instantaneous growth rate and long‐term fitness: Consequences for microbial physiology and predictive computational models	7
Copulation Song in Drosophila: Do Females Sing to Change Male Ejaculate Allocation and Incite Postcopulatory Mate Choice?	7
No neonates without adults	7
Epigenetic rejuvenation by partial reprogramming	7
Co‐translational folding of nascent polypeptides: Multi‐layered mechanisms for the efficient biogenesis of functional proteins	7
Predatory Preprint Servers Join Predatory Journals in the Paper Mill Industry…	7
Do seasonal microbiome changes affect infection susceptibility, contributing to seasonal disease outbreaks?	7
Raman spectroscopy is a powerful tool in molecular paleobiology: An analytical response to Alleon et al. (https://doi.org/10.1002/bies.202000295)	7
How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?	7
Inheritance and maintenance of small RNA‐mediated epigenetic effects	7
Liquid–liquid phase separation drives the β‐catenin destruction complex formation	7
Does transcriptional heterogeneity facilitate the development of genetic drug resistance?	7
Heritable Epigenetic Changes Alter Transgenerational Waveforms Maintained by Cycling Stores of Information	7
Personalized health and the coronavirus vaccines—Do individual genetics matter?	7
Meiosis I Kinase Regulators: Conserved Orchestrators of Reductional Chromosome Segregation	7
Perirhinal cortex area 35 controls the functional link between the perirhinal and entorhinal‐hippocampal circuitry	7
The Sexual Ancestor of all Eukaryotes: A Defense of the “Meiosis Toolkit”	6
Teeth reveal juvenile diet, health and neurotoxicant exposure retrospectively: What biological rhythms and chemical records tell us	6
Apoptotic mitochondrial poration by a growing list of pore‐forming BCL‐2 family proteins	6
Assay technologies facilitating drug discovery for ADP‐ribosyl writers, readers and erasers	6
Models for human porphyrias: Have animals in the wild been overlooked?	6
Why does COVID‐19 pathology have several clinical forms?	6
The cap epitranscriptome: Early directions to a complex life as mRNA	6
Collective cell migration driven by filopodia—New insights from the social behavior of myotubes	6
Modulation of H3.3 chromatin assembly by PML: A way to regulate epigenetic inheritance	6
Potential of the CRISPR‐Cas system for improved parasite diagnosis	6
KCTD10 Biology: An Adaptor for the Ubiquitin E3 Complex Meets Multiple Substrates	6
Nucleosomes and flipons exchange energy to alter chromatin conformation, the readout of genomic information, and cell fate	6
The XK plasma membrane scramblase and the VPS13A cytosolic lipid transporter for ATP‐induced cell death	6
Beyond the GTP‐cap: Elucidating the molecular mechanisms of microtubule catastrophe	6
Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology	6
Foraminifera as a model of the extensive variability in genome dynamics among eukaryotes	6
Flipping and other astonishing transporter dance moves in fungal drug resistance	6
Sorting of cargo in the tubular endosomal network	6
Distinguishing serial homologs from novel traits: Experimental limitations and ideas for improvements	6
The circle of Willis revisited: Forebrain dehydration sensing facilitated by the anterior communicating artery	6
The strange case of Drp1 in autophagy: Jekyll and Hyde?	6
Function moves biomolecular condensates in phase space	6
Bayes and Darwin: How replicator populations implement Bayesian computations	6
Microbiome Structure and Function: A New Framework for Interpreting Data	6
There is no evidence of SARS‐CoV‐2 laboratory origin: Response to Segreto and Deigin (DOI: 10.1002/bies.202000240)	6
Embryonic movement stimulates joint formation and development: Implications in arthrogryposis multiplex congenita	6
Anillin: The First Proofreading‐like Scaffold?	6
Using primary teeth and archived dried spots for exposomic studies in children: Exploring new paths in the environmental epidemiology of pediatric cancer	6
Skin aging: Dermal adipocytes metabolically reprogram dermal fibroblasts	6
A Novel Eukaryote‐Like CRISPR Activation Tool in Bacteria: Features and Capabilities	6
Rebirth of the translational machinery: The importance of recycling ribosomes	6
Broad H3K4me3 domains: Maintaining cellular identity and their implication in super‐enhancer hijacking	5
A Contemporary Message from Mendel's Logical Empiricism	5
Functional interplay within the epitranscriptome: Reality or fiction?	5
The Study That Made Rats Jump for Joy, and Then Killed Them	5
Transcription factors regulate early T cell development via redeployment of other factors	5
Keeping the balance: The noncoding RNA 7SK as a master regulator for neuron development and function	5
Biological sex is binary, even though there is a rainbow of sex roles	5
The axonal radial contractility: Structural basis underlying a new form of neural plasticity	5
Proteolytic control in ciliogenesis: Temporal restriction or early initiation?	5
Amphibian regeneration and mammalian cancer: Similarities and contrasts from an evolutionary biology perspective	5
Why PGD2 has different functions from PGE2	5
CHRONOCRISIS: When Cell Cycle Asynchrony Generates DNA Damage in Polyploid Cells	5