OOIR: Observatory of International Research

Papers

(The TQCC of Natural Product Reports is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	203
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	170
Privileged natural product compound classes for anti-inflammatory drug development	126
Silybin and its congeners: from traditional medicine to molecular effects	125
Biosynthesis, regulation, and engineering of natural products from Lysobacter	120
Harnessing microbial co-culture to increase the production of known secondary metabolites	101
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	100
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	99
Front cover	95
Back cover	90
Inside front cover	78
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	78
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	78
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	77
Medicinal plant resin natural products: structural diversity and biological activities	74
Streptomyces cell-free systems for natural product discovery and engineering	71
Discovery, bioactivity and biosynthesis of fungal piperazines	69
Introduction to engineering the biosynthesis of fungal natural products	67
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	66
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	65
Front cover	64
Inside front cover	64
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	62
Correction: Dearomative logic in natural product total synthesis	62
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	58

Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	58
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	55
Chemoenzymatic approaches to plant natural product inspired compounds	55
Marine natural products	54
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	50
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	49
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	48
Contents list	47
Enzymatic ester bond formation strategies in fungal macrolide skeletons	47
Contents list	47
Front cover	47
Back cover	46
Contents list	45
Image to insight: exploring natural products through mass spectrometry imaging	44
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	44
Synthetic-bioinformatic natural product-inspired peptides	44
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	43
Hot off the Press	41
Biosynthesis of fungal terpenoids	41
Contents list	41
Front cover	39
Front cover	39
Strategies for the synthesis ofStemonaalkaloids: an update	38
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	37
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	37
Enzymatic crosslinking of histidine side chains in peptide natural products	37
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	36
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	36
Illuminating the dark space of bioactive peptides with mass spectrometry	36
Technological developments driving industrial natural product discovery	36
Back cover	35
Contents list	35
Inside front cover	33
Hot off the Press	33
Back cover	33
Back cover	33
Contents list	32
Synthesis of rearranged indole diterpenes of the paxilline type	32
Back cover	32
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	32
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	31
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	31
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	30
Engineering the biosynthesis of fungal nonribosomal peptides	30
Recent advances in oxidative phenol coupling for the total synthesis of natural products	29
The shikimate pathway: gateway to metabolic diversity	29
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	29
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	29
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	29
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	29

Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	28
Contents list	28
Natural products as anthelmintics: safeguarding animal health	28
Back cover	28
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	27
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	27
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	27
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	26
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	26
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	26
Contents list	25
Back cover	25
Front cover	25
Contents list	25
Semi-synthesis in the exploration of opioid-targeting natural products	25
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	24
Contents list	24
Biosynthesis and bioactivities of microbial genotoxin colibactins	24
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	24
Analytical methods for the analysis of volatile natural products	23
The chemical and biological properties of natural resorcylic acid lactones	23
The action of phytochemicals in biofilm control	23
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	23
Warfare under the waves: a review of bacteria-derived algaecidal natural products	22
Opportunities and challenges of RiPP-based therapeutics	22
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	22
Contents list	21
Contents list	21
Front cover	21
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	21
Egg toxic compounds in the animal kingdom. A comprehensive review	21
Back cover	20
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	20
Contents list	20
The development of Burkholderia bacteria as heterologous hosts	20
Back cover	20
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	20
Intramolecular cycloaddition of nitrones in total synthesis of natural products	20
The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism	19
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	19
40 Years of Natural Product Reports	19
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	19
Challenges and opportunities for cheat therapy in the control of bacterial infections	19
Contents list	19