OOIR: Observatory of International Research

Papers

(The TQCC of Natural Product Reports is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Privileged natural product compound classes for anti-inflammatory drug development	218
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	194
Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis	156
Silybin and its congeners: from traditional medicine to molecular effects	147
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	141
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	118
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	117
Harnessing microbial co-culture to increase the production of known secondary metabolites	117
Biosynthesis, regulation, and engineering of natural products from Lysobacter	111
Inside front cover	111
Front cover	108
Back cover	96
Introduction to engineering the biosynthesis of fungal natural products	94
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products	92
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	88
Medicinal plant resin natural products: structural diversity and biological activities	87
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	85
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	82
Streptomyces cell-free systems for natural product discovery and engineering	82
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	81
Discovery, bioactivity and biosynthesis of fungal piperazines	77
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	77
Front cover	74
Inside front cover	72
Correction: Dearomative logic in natural product total synthesis	69

Streptomyces as a versatile host platform for heterologous production of microbial natural products	68
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	67
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	67
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	65
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	65
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	63
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	60
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	59
Contents list	56
Enzymatic ester bond formation strategies in fungal macrolide skeletons	56
Marine natural products	55
Back cover	53
Chemoenzymatic approaches to plant natural product inspired compounds	53
Front cover	52
Contents list	52
Contents list	51
Contents list	49
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	48
Image to insight: exploring natural products through mass spectrometry imaging	47
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	46
Synthetic-bioinformatic natural product-inspired peptides	46
Biosynthesis of fungal terpenoids	46
Inside front cover	46
Front cover	45
Front cover	45
Contents list	45
Illuminating the dark space of bioactive peptides with mass spectrometry	44
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	43
Strategies for the synthesis ofStemonaalkaloids: an update	42
Back cover	42
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	41
Technological developments driving industrial natural product discovery	41
Back cover	41
Hot off the Press	40
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	40
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	39
Enzymatic crosslinking of histidine side chains in peptide natural products	39
Back cover	39
Back cover	38
Inside front cover	38
Back cover	37
Hot off the Press	37
Contents list	37
Contents list	36
Back cover	36
Synthesis of rearranged indole diterpenes of the paxilline type	35
Engineering the biosynthesis of fungal nonribosomal peptides	35
Front cover	35
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	34
Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches	34

Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	34
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	34
Biosynthesis of invertebrate-derived natural products: an uncharted territory	33
AI and mechanistic modeling for characterizing biosynthetic pathways of natural products	33
Recent advances in oxidative phenol coupling for the total synthesis of natural products	33
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	33
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	32
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	32
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	31
Back cover	31
The shikimate pathway: gateway to metabolic diversity	31
Contents list	31
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	30
Natural products as anthelmintics: safeguarding animal health	30
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	30
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	30
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	29
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	29
Semi-synthesis in the exploration of opioid-targeting natural products	29
Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis	29
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	28
Front cover	28
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	28
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	28
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	28
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	27
Biosynthesis and bioactivities of microbial genotoxin colibactins	27
Contents list	27
Analytical methods for the analysis of volatile natural products	27
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	27
Back cover	27
Contents list	27
Contents list	27
Warfare under the waves: a review of bacteria-derived algaecidal natural products	26
The chemical and biological properties of natural resorcylic acid lactones	26
Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions	26
The action of phytochemicals in biofilm control	26
Opportunities and challenges of RiPP-based therapeutics	25
Contents list	25
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	25
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	25
Back cover	24
Front cover	24
Contents list	24
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	23
Contents list	23
Egg toxic compounds in the animal kingdom. A comprehensive review	23
Back cover	23
Intramolecular cycloaddition of nitrones in total synthesis of natural products	22
The development of Burkholderia bacteria as heterologous hosts	22
A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids	22
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	22
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	22