OOIR: Observatory of International Research

Papers

(The TQCC of Natural Product Reports is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	214
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	188
Privileged natural product compound classes for anti-inflammatory drug development	144
Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis	143
Silybin and its congeners: from traditional medicine to molecular effects	139
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	115
Biosynthesis, regulation, and engineering of natural products from Lysobacter	115
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	112
Harnessing microbial co-culture to increase the production of known secondary metabolites	110
Inside front cover	108
Front cover	103
Introduction to engineering the biosynthesis of fungal natural products	94
Back cover	94
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	91
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	87
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products	85
Streptomyces cell-free systems for natural product discovery and engineering	82
Discovery, bioactivity and biosynthesis of fungal piperazines	80
Medicinal plant resin natural products: structural diversity and biological activities	80
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	78
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	76
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	75
Front cover	73
Inside front cover	68
Correction: Dearomative logic in natural product total synthesis	67

Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	66
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	65
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	64
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	63
Marine natural products	62
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	58
Chemoenzymatic approaches to plant natural product inspired compounds	57
Streptomyces as a versatile host platform for heterologous production of microbial natural products	56
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	55
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	55
Enzymatic ester bond formation strategies in fungal macrolide skeletons	53
Back cover	52
Front cover	51
Contents list	51
Contents list	50
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	49
Contents list	49
Biosynthesis of fungal terpenoids	45
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	45
Image to insight: exploring natural products through mass spectrometry imaging	45
Synthetic-bioinformatic natural product-inspired peptides	45
Front cover	44
Contents list	44
Front cover	44
Illuminating the dark space of bioactive peptides with mass spectrometry	43
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	42
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	42
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	41
Back cover	40
Technological developments driving industrial natural product discovery	40
Back cover	40
Enzymatic crosslinking of histidine side chains in peptide natural products	39
Hot off the Press	39
Strategies for the synthesis ofStemonaalkaloids: an update	39
Inside front cover	38
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	38
Back cover	38
Hot off the Press	37
Back cover	37
Contents list	37
Back cover	37
Back cover	37
Contents list	36
Engineering the biosynthesis of fungal nonribosomal peptides	35
AI and mechanistic modeling for characterizing biosynthetic pathways of natural products	35
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	35
Synthesis of rearranged indole diterpenes of the paxilline type	34
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	34
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	34
Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches	33

Recent advances in oxidative phenol coupling for the total synthesis of natural products	33
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	33
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	33
The shikimate pathway: gateway to metabolic diversity	32
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	31
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	31
Contents list	31
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	30
Back cover	30
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	30
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	30
Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis	29
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	29
Semi-synthesis in the exploration of opioid-targeting natural products	29
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	28
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	28
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	28
Natural products as anthelmintics: safeguarding animal health	28
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	28
Contents list	27
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	27
Contents list	27
Front cover	27
Back cover	27
Contents list	26
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	26
Biosynthesis and bioactivities of microbial genotoxin colibactins	26
Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions	26
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	26
The chemical and biological properties of natural resorcylic acid lactones	25
Analytical methods for the analysis of volatile natural products	25
Warfare under the waves: a review of bacteria-derived algaecidal natural products	25
Opportunities and challenges of RiPP-based therapeutics	25
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	25
The action of phytochemicals in biofilm control	24
Back cover	24
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	24
Contents list	24
Contents list	23
Egg toxic compounds in the animal kingdom. A comprehensive review	23
Front cover	23
Back cover	23
Contents list	23
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	22
Challenges and opportunities for cheat therapy in the control of bacterial infections	22
40 Years of Natural Product Reports	22
Intramolecular cycloaddition of nitrones in total synthesis of natural products	22
A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids	22
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	22
The development of Burkholderia bacteria as heterologous hosts	22
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	22
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	22