Natural Product Reports

Papers
(The TQCC of Natural Product Reports is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)
ArticleCitations
New developments in RiPP discovery, enzymology and engineering471
Marine natural products261
Marine natural products166
Marine natural products117
The scaffold-forming steps of plant alkaloid biosynthesis115
Natural products in agarwood andAquilariaplants: chemistry, biological activities and biosynthesis109
Cytochrome P450 enzymes in fungal natural product biosynthesis108
A roadmap for metagenomic enzyme discovery96
Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches96
Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities95
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide92
Bacterial terpenome91
Triptolide: reflections on two decades of research and prospects for the future91
Traditional Chinese medicine (TCM) as a source of new anticancer drugs83
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities76
Genome mining methods to discover bioactive natural products75
Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.75
Terpenoids from the medicinal mushroomAntrodia camphorata: chemistry and medicinal potential69
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis67
Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota66
Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy65
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis64
Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology63
Machine learning approaches for elucidating the biological effects of natural products63
Solanum steroidal glycoalkaloids: structural diversity, biological activities, and biosynthesis62
Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits61
Anthracyclines: biosynthesis, engineering and clinical applications60
Microbial natural product databases: moving forward in the multi-omics era58
Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products57
Regio- and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis56
Biosynthesis, evolution and ecology of microbial terpenoids56
Fungal–fungal co-culture: a primer for generating chemical diversity54
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos54
The year 2020 in natural product bioinformatics: an overview of the latest tools and databases51
Enzymatic dimerization in the biosynthetic pathway of microbial natural products51
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis51
The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs50
How different are marine microbial natural products compared to their terrestrial counterparts?47
Alternative metabolic pathways and strategies to high-titre terpenoid production inEscherichia coli46
Biosynthesis of azaphilones: a review46
Biosynthesis of cyclopropane in natural products45
Marine paralytic shellfish toxins: chemical properties, mode of action, newer analogues, and structure–toxicity relationship45
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis45
Naturally occurring prenylated chalcones from plants: structural diversity, distribution, activities and biosynthesis44
Chemistry of fungal meroterpenoid cyclases44
Natural product C-glycosyltransferases – a scarcely characterised enzymatic activity with biotechnological potential44
Advancements in capturing and mining mass spectrometry data are transforming natural products research44
Unlocking the potential of marine biodiscovery43
Skipped dienes in natural product synthesis42
Sesterterpenoids: chemistry, biology, and biosynthesis42
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses41
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)41
Research progress of meliaceous limonoids from 2011 to 202140
Structure–function relationship of terpenoid glycosyltransferases from plants40
The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis39
Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products39
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded inStreptomycesgenomes38
Bottromycins - biosynthesis, synthesis and activity38
Multi-colored shades of betalains: recent advances in betacyanin chemistry38
Cytotoxic and antitumor peptides as novel chemotherapeutics38
Tropane alkaloid biosynthesis: a centennial review37
Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons36
Dearomative logic in natural product total synthesis35
The chemical ecology of the fungus-farming termite symbiosis35
The beauty of biocatalysis: sustainable synthesis of ingredients in cosmetics35
Plant biosynthetic gene clusters in the context of metabolic evolution35
MicroED in natural product and small molecule research35
Natural withanolides, an update35
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic34
Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria34
The confluence of big data and evolutionary genome mining for the discovery of natural products34
Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)34
Ring systems in natural products: structural diversity, physicochemical properties, and coverage by synthetic compounds33
The chemistry and biology of guanidine secondary metabolites33
Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds33
Cheminformatic analysis of natural product-based drugs and chemical probes33
Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity33
Ribosomally synthesized peptides, foreground players in microbial interactions: recent developments and unanswered questions32
The application potential of machine learning and genomics for understanding natural product diversity, chemistry, and therapeutic translatability32
Recent advances in the synthesis of ent-kaurane diterpenoids32
Biosynthesis of pyrroloindoline-containing natural products32
Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases31
N,C-Coupled naphthylisoquinoline alkaloids: a versatile new class of axially chiral natural products31
Image to insight: exploring natural products through mass spectrometry imaging30
Integrative omics approaches for biosynthetic pathway discovery in plants30
The synthesis of biologically active indolocarbazole natural products29
S-Adenosylmethionine: more than just a methyl donor29
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design29
Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining29
Biosynthesis and heterologous production of furanocoumarins: perspectives and current challenges28
Silybin and its congeners: from traditional medicine to molecular effects28
Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)27
Balancing skeleton and functional groups in total syntheses of complex natural products: a case study of tigliane, daphnane and ingenane diterpenoids27
Artificial intelligence in microbial natural product drug discovery: current and emerging role26
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature25
Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation25
Anthraquinone-fused enediynes: discovery, biosynthesis and development24
Streptomyces cell-free systems for natural product discovery and engineering24
Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi24
Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces24
Molecules derived from the extremes of life: a decade later24
Polyketide β-branching: diversity, mechanism and selectivity23
Trends of antimalarial marine natural products: progresses, challenges and opportunities23
Polypharmacology of andrographolide: beyond one molecule one target23
Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism22
Engineering the biosynthesis of fungal nonribosomal peptides22
Marine natural products22
Study towards improving artemisinin-based combination therapies22
Microbial engineering for the production of C2–C6organic acids21
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions21
Selaginellins from the genusSelaginella: isolation, structure, biological activity, and synthesis21
Cryptic halogenation reactions in natural product biosynthesis20
The isolation of water-soluble natural products – challenges, strategies and perspectives20
Bioactive natural products from Bacteroidetes20
Chemical labeling strategies for small molecule natural product detection and isolation20
The tryptophan connection: cyclic peptide natural products linkedviathe tryptophan side chain20
Predicting biochemical and physiological effects of natural products from molecular structures using machine learning20
Biosynthetic strategies for tetramic acid formation20
A straightforward access to trifluoromethylated natural products through late-stage functionalization20
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives20
Out for a RiPP: challenges and advances in genome mining of ribosomal peptides from fungi19
Engineering yeast for the production of plant terpenoids using synthetic biology approaches19
Cis double bond formation in polyketide biosynthesis19
Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae19
Recent advances in total syntheses of natural products containing the benzocycloheptane motif19
0.5869288444519