OOIR: Observatory of International Research

Papers

(The TQCC of Natural Product Reports is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	206
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	172
Harnessing microbial co-culture to increase the production of known secondary metabolites	131
Silybin and its congeners: from traditional medicine to molecular effects	131
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	124
Privileged natural product compound classes for anti-inflammatory drug development	105
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	104
Biosynthesis, regulation, and engineering of natural products from Lysobacter	103
Front cover	98
Back cover	97
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	82
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products	81
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	79
Introduction to engineering the biosynthesis of fungal natural products	78
Medicinal plant resin natural products: structural diversity and biological activities	76
Inside front cover	75
Streptomyces cell-free systems for natural product discovery and engineering	73
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	72
Discovery, bioactivity and biosynthesis of fungal piperazines	67
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	67
Front cover	66
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	66
Inside front cover	64
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	62
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	62

Correction: Dearomative logic in natural product total synthesis	61
Chemoenzymatic approaches to plant natural product inspired compounds	58
Enzymatic ester bond formation strategies in fungal macrolide skeletons	57
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	57
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	51
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	50
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	50
Front cover	48
Contents list	48
Marine natural products	48
Contents list	48
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	48
Back cover	47
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	47
Contents list	47
Image to insight: exploring natural products through mass spectrometry imaging	45
Biosynthesis of fungal terpenoids	44
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	43
Synthetic-bioinformatic natural product-inspired peptides	43
Hot off the Press	42
Contents list	41
Front cover	39
Front cover	39
Strategies for the synthesis ofStemonaalkaloids: an update	38
Technological developments driving industrial natural product discovery	38
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	38
Enzymatic crosslinking of histidine side chains in peptide natural products	37
Illuminating the dark space of bioactive peptides with mass spectrometry	37
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	37
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	37
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	37
Contents list	36
Back cover	36
Back cover	35
Back cover	34
Inside front cover	34
Hot off the Press	34
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	33
Synthesis of rearranged indole diterpenes of the paxilline type	33
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	32
Engineering the biosynthesis of fungal nonribosomal peptides	32
Back cover	32
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	32
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	32
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	31
Recent advances in oxidative phenol coupling for the total synthesis of natural products	31
Contents list	31
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	30
The shikimate pathway: gateway to metabolic diversity	30
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	29

Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	29
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	29
Back cover	28
Semi-synthesis in the exploration of opioid-targeting natural products	28
Natural products as anthelmintics: safeguarding animal health	28
Contents list	28
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	28
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	28
Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis	27
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	27
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	26
Front cover	26
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	26
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	26
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	25
Contents list	25
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	25
Back cover	25
Contents list	25
Analytical methods for the analysis of volatile natural products	24
Opportunities and challenges of RiPP-based therapeutics	24
Contents list	24
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	23
Biosynthesis and bioactivities of microbial genotoxin colibactins	23
The chemical and biological properties of natural resorcylic acid lactones	23
Contents list	22
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	22
Egg toxic compounds in the animal kingdom. A comprehensive review	22
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	22
Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions	22
The action of phytochemicals in biofilm control	22
Warfare under the waves: a review of bacteria-derived algaecidal natural products	22
The development of Burkholderia bacteria as heterologous hosts	21
Contents list	21
Front cover	21
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	21
Back cover	21
Back cover	21
Contents list	21
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	20
The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism	20
Intramolecular cycloaddition of nitrones in total synthesis of natural products	20
40 Years of Natural Product Reports	20
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	20
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	20
Contents list	20