OOIR: Observatory of International Research

Papers

(The TQCC of Natural Product Reports is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
New developments in RiPP discovery, enzymology and engineering	471
Marine natural products	261
Marine natural products	166
Marine natural products	117
The scaffold-forming steps of plant alkaloid biosynthesis	115
Natural products in agarwood andAquilariaplants: chemistry, biological activities and biosynthesis	109
Cytochrome P450 enzymes in fungal natural product biosynthesis	108
A roadmap for metagenomic enzyme discovery	96
Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches	96
Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities	95
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	92
Bacterial terpenome	91
Triptolide: reflections on two decades of research and prospects for the future	91
Traditional Chinese medicine (TCM) as a source of new anticancer drugs	83
Genome mining methods to discover bioactive natural products	77
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities	76
Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.	75
Terpenoids from the medicinal mushroomAntrodia camphorata: chemistry and medicinal potential	69
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	67
Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota	66
Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy	65
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	64
Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology	63
Machine learning approaches for elucidating the biological effects of natural products	63
Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits	62

Solanum steroidal glycoalkaloids: structural diversity, biological activities, and biosynthesis	62
Anthracyclines: biosynthesis, engineering and clinical applications	61
Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products	58
Microbial natural product databases: moving forward in the multi-omics era	58
Regio- and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis	56
Biosynthesis, evolution and ecology of microbial terpenoids	56
Fungal–fungal co-culture: a primer for generating chemical diversity	54
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos	54
The year 2020 in natural product bioinformatics: an overview of the latest tools and databases	51
Enzymatic dimerization in the biosynthetic pathway of microbial natural products	51
The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs	51
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis	51
How different are marine microbial natural products compared to their terrestrial counterparts?	47
Marine paralytic shellfish toxins: chemical properties, mode of action, newer analogues, and structure–toxicity relationship	46
Biosynthesis of azaphilones: a review	46
Alternative metabolic pathways and strategies to high-titre terpenoid production inEscherichia coli	46
Biosynthesis of cyclopropane in natural products	45
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	45
Advancements in capturing and mining mass spectrometry data are transforming natural products research	44
Chemistry of fungal meroterpenoid cyclases	44
Natural product C-glycosyltransferases – a scarcely characterised enzymatic activity with biotechnological potential	44
Naturally occurring prenylated chalcones from plants: structural diversity, distribution, activities and biosynthesis	44
Unlocking the potential of marine biodiscovery	43
Skipped dienes in natural product synthesis	42
Sesterterpenoids: chemistry, biology, and biosynthesis	42
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)	41
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	41
Research progress of meliaceous limonoids from 2011 to 2021	40
Structure–function relationship of terpenoid glycosyltransferases from plants	40
The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis	39
Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products	39
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded inStreptomycesgenomes	38
Bottromycins - biosynthesis, synthesis and activity	38
Multi-colored shades of betalains: recent advances in betacyanin chemistry	38
Cytotoxic and antitumor peptides as novel chemotherapeutics	38
Tropane alkaloid biosynthesis: a centennial review	37
Plant biosynthetic gene clusters in the context of metabolic evolution	37
Ring systems in natural products: structural diversity, physicochemical properties, and coverage by synthetic compounds	36
Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons	36
The beauty of biocatalysis: sustainable synthesis of ingredients in cosmetics	35
Natural withanolides, an update	35
MicroED in natural product and small molecule research	35
Dearomative logic in natural product total synthesis	35
The chemical ecology of the fungus-farming termite symbiosis	35
Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria	34
The confluence of big data and evolutionary genome mining for the discovery of natural products	34
Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)	34
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	34
Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds	33
The chemistry and biology of guanidine secondary metabolites	33

Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity	33
Cheminformatic analysis of natural product-based drugs and chemical probes	33
The application potential of machine learning and genomics for understanding natural product diversity, chemistry, and therapeutic translatability	32
Ribosomally synthesized peptides, foreground players in microbial interactions: recent developments and unanswered questions	32
Biosynthesis of pyrroloindoline-containing natural products	32
N,C-Coupled naphthylisoquinoline alkaloids: a versatile new class of axially chiral natural products	32
Image to insight: exploring natural products through mass spectrometry imaging	32
Recent advances in the synthesis of ent-kaurane diterpenoids	32
Integrative omics approaches for biosynthetic pathway discovery in plants	31
Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases	31
The synthesis of biologically active indolocarbazole natural products	29
S-Adenosylmethionine: more than just a methyl donor	29
Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining	29
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design	29
Biosynthesis and heterologous production of furanocoumarins: perspectives and current challenges	28
Silybin and its congeners: from traditional medicine to molecular effects	28
Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces	28
Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)	27
Balancing skeleton and functional groups in total syntheses of complex natural products: a case study of tigliane, daphnane and ingenane diterpenoids	27
Artificial intelligence in microbial natural product drug discovery: current and emerging role	26
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature	25
Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation	25
Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi	24
Molecules derived from the extremes of life: a decade later	24
Anthraquinone-fused enediynes: discovery, biosynthesis and development	24
Streptomyces cell-free systems for natural product discovery and engineering	24
Polyketide β-branching: diversity, mechanism and selectivity	23
Trends of antimalarial marine natural products: progresses, challenges and opportunities	23
Polypharmacology of andrographolide: beyond one molecule one target	23
Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism	22
Engineering the biosynthesis of fungal nonribosomal peptides	22
Marine natural products	22
Study towards improving artemisinin-based combination therapies	22
Microbial engineering for the production of C₂–C₆organic acids	21
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	21
Selaginellins from the genusSelaginella: isolation, structure, biological activity, and synthesis	21
Predicting biochemical and physiological effects of natural products from molecular structures using machine learning	20
Biosynthetic strategies for tetramic acid formation	20
The tryptophan connection: cyclic peptide natural products linkedviathe tryptophan side chain	20
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives	20
Chemical labeling strategies for small molecule natural product detection and isolation	20
The isolation of water-soluble natural products – challenges, strategies and perspectives	20
Bioactive natural products from Bacteroidetes	20
Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae	20
Cryptic halogenation reactions in natural product biosynthesis	20
A straightforward access to trifluoromethylated natural products through late-stage functionalization	20
Cis double bond formation in polyketide biosynthesis	19
Engineering yeast for the production of plant terpenoids using synthetic biology approaches	19
Recent advances in total syntheses of natural products containing the benzocycloheptane motif	19
Out for a RiPP: challenges and advances in genome mining of ribosomal peptides from fungi	19