OOIR: Observatory of International Research

Papers

(The TQCC of Natural Product Reports is 21. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	213
Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis	183
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	142
Privileged natural product compound classes for anti-inflammatory drug development	138
Biosynthesis, regulation, and engineering of natural products from Lysobacter	138
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	115
Harnessing microbial co-culture to increase the production of known secondary metabolites	113
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	106
Silybin and its congeners: from traditional medicine to molecular effects	105
Inside front cover	104
Front cover	94
Back cover	91
Streptomyces cell-free systems for natural product discovery and engineering	88
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	88
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	86
Introduction to engineering the biosynthesis of fungal natural products	82
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products	80
Medicinal plant resin natural products: structural diversity and biological activities	77
Discovery, bioactivity and biosynthesis of fungal piperazines	77
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	74
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	73
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	72
Front cover	71
Streptomyces as a versatile host platform for heterologous production of microbial natural products	66
Inside front cover	65

Enzymatic ester bond formation strategies in fungal macrolide skeletons	64
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	63
Correction: Dearomative logic in natural product total synthesis	61
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	59
Chemoenzymatic approaches to plant natural product inspired compounds	59
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	56
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	54
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	54
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	53
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	53
Back cover	52
Marine natural products	52
Front cover	50
Contents list	50
Contents list	49
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	48
Contents list	48
Synthetic-bioinformatic natural product-inspired peptides	45
Biosynthesis of fungal terpenoids	44
Image to insight: exploring natural products through mass spectrometry imaging	44
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	43
Front cover	43
Hot off the Press	42
Contents list	42
Strategies for the synthesis ofStemonaalkaloids: an update	41
Front cover	41
Illuminating the dark space of bioactive peptides with mass spectrometry	40
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	40
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	40
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	39
Back cover	39
Back cover	38
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	38
Enzymatic crosslinking of histidine side chains in peptide natural products	38
Back cover	37
Back cover	37
Technological developments driving industrial natural product discovery	37
Inside front cover	37
Back cover	37
Hot off the Press	36
Contents list	36
Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches	35
Contents list	35
Back cover	35
Recent advances in oxidative phenol coupling for the total synthesis of natural products	34
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	34
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	33
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	33
Synthesis of rearranged indole diterpenes of the paxilline type	33
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	32

Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	32
Engineering the biosynthesis of fungal nonribosomal peptides	31
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	31
The shikimate pathway: gateway to metabolic diversity	31
Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis	30
Back cover	30
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	30
Contents list	30
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	29
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	29
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	29
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	29
Semi-synthesis in the exploration of opioid-targeting natural products	28
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	28
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	28
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	28
Natural products as anthelmintics: safeguarding animal health	27
Front cover	27
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	27
Contents list	26
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	26
Contents list	26
Contents list	26
Back cover	26
The chemical and biological properties of natural resorcylic acid lactones	25
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	25
Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions	25
Opportunities and challenges of RiPP-based therapeutics	25
Warfare under the waves: a review of bacteria-derived algaecidal natural products	25
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	25
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	25
Analytical methods for the analysis of volatile natural products	25
The action of phytochemicals in biofilm control	24
Contents list	24
Biosynthesis and bioactivities of microbial genotoxin colibactins	24
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	24
Back cover	23
Front cover	23
Contents list	23
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	22
The development of Burkholderia bacteria as heterologous hosts	22
Egg toxic compounds in the animal kingdom. A comprehensive review	22
Back cover	22
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	22
Contents list	22
Intramolecular cycloaddition of nitrones in total synthesis of natural products	22
A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids	22
The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism	21
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	21
Challenges and opportunities for cheat therapy in the control of bacterial infections	21
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	21