Natural Product Reports

Article	Citations
Privileged natural product compound classes for anti-inflammatory drug development	209
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	201
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	152
Syntheses of furan natural products	142
Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis	109
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	103
Harnessing microbial co-culture to increase the production of known secondary metabolites	97
Inside front cover	80
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products	72
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	70
Discovery, bioactivity and biosynthesis of fungal piperazines	67
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	64
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	61
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	59
Medicinal plant resin natural products: structural diversity and biological activities	59
Introduction to engineering the biosynthesis of fungal natural products	57
Streptomyces cell-free systems for natural product discovery and engineering	55
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	52
Front cover	52
Inside front cover	51
Contents list	49
Charting the path for l -tyrosine derivatives: from engineering strategies to microbial cell factories	49
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	49
Highlights of cyanobacterial metabolites reported between 2021–2024	48
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	47

Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	47
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	46
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	44
Marine natural products	44
Enzymatic ester bond formation strategies in fungal macrolide skeletons	43
Streptomyces as a versatile host platform for heterologous production of microbial natural products	43
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	43
Back cover	41
Contents list	41
Front cover	41
Inside front cover	40
Inside front cover	40
Synthetic-bioinformatic natural product-inspired peptides	40
Contents list	40
Front cover	39
Editorial: Microbial host and metabolic engineering for natural product discovery and production	39
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	38
Biosynthesis of fungal terpenoids	38
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	36
Front cover	35
Front cover	35
Enzymatic crosslinking of histidine side chains in peptide natural products	34
Illuminating the dark space of bioactive peptides with mass spectrometry	34
Front cover	34
Technological developments driving industrial natural product discovery	34
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	34
Back cover	33
Back cover	33
Brief overview of recently reported misassigned natural products and their in silico revisions enabled by DU8ML, a machine learning-augmented DFT computa	32
Hot off the Press	32
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	31
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	31
Natural products modulating interleukin-mediated pathways for anti-allergic and immunomodulatory effects	31
Back cover	31
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	31
Contents list	30
Hot off the Press	29
Back cover	28
Contents list	27
Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches	26
AI and mechanistic modeling for characterizing biosynthetic pathways of natural products	25
Front cover	25
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	25
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	24
Recent advances in oxidative phenol coupling for the total synthesis of natural products	24
Biosynthesis of invertebrate-derived natural products: an uncharted territory	24
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	24
Back cover	23
Semi-synthesis in the exploration of opioid-targeting natural products	23
The shikimate pathway: gateway to metabolic diversity	23

Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	23
Engineering the biosynthesis of fungal nonribosomal peptides	23
Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis	23
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	22
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	22
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	21
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	21
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	21
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	21
Natural products as anthelmintics: safeguarding animal health	20
Contents list	20
Contents list	20
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	19
The action of phytochemicals in biofilm control	19
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	19
Analytical methods for the analysis of volatile natural products	19
Contents list	19
Hot off the Press	18
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	18
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	18
Contents list	18
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	18
Warfare under the waves: a review of bacteria-derived algaecidal natural products	17
S -Adenosylmethionine: considerations on its role in the origin and evolution of life	17
The chemical and biological properties of natural resorcylic acid lactones	17
Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions	17
Opportunities and challenges of RiPP-based therapeutics	17
Back cover	16
Contents list	16
Contents list	16
Contents list	16
The development of Burkholderia bacteria as heterologous hosts	15
Intramolecular cycloaddition of nitrones in total synthesis of natural products	15
Inside front cover	15
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	15
Back cover	15
40 Years of Natural Product Reports	15
A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids	15
Contents list	15
Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer	14
Rotenoid diversity, distribution and evolution in plant lineages	14
The bisintercalator family of nonribosomal peptides: structural diversity and biosynthetic mechanism	14
Specialized metabolite modifications in Brassicaceae seeds and plants: diversity, functions and related enzymes	14
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	14
Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products	14
Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth	14
Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases	14
Contents list	13
Contents list	13
Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)	13
Inside front cover	13
Front cover	13
Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis	13
Back cover	13
Contents list	13
Trends in metabolite discovery from Actinomycetes	12
Embracing the era of antimicrobial peptides with marine organisms	12
Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers	12
Front cover	12
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria	12
Introduction to volatile natural products	12
Engineering fungal terpene biosynthesis	12
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	11
Advances in the discovery and study of Trichoderma natural products for biological control applications	11
Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides	11
Natural product inspired antibiotics approved for human use – 1943 to 2025	11
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022	11
Back cover	10
Hot off the Press	10
Back cover	10
The Kornblum DeLaMare rearrangement in natural product synthesis: 25 years of innovation	10
Back cover	10
Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis	10
Accelerating enzyme discovery and engineering with high-throughput screening	9
Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites	9
Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states	8
Extraction techniques for bioactive compounds of cannabis	8
Organic synthesis in the study of terpene-derived oxidation products in the atmosphere	8
Natural products influence bacteriophage infectivity	8
Chemical diversity of cyanobacterial natural products	8

Engineering class I terpene synthases for skeletal diversity: strategies and applications	8
Meroterpenoids? A historical and critical review of this biogenetic determinant	7
Back cover	7
Fe(ii) and 2-oxoglutarate-dependent dioxygenases for natural product synthesis: molecular insights into reaction diversity	7
Chemistry and biology of natural stilbenes: an update	7
Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ	7
Scaling up for success: from bioactive natural products to new medicines	7
Inside front cover	7
Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers	7
The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis	6
Back cover	6
Hot off the Press	6
Contents list	6
Halogenases and dehalogenases: mechanisms, engineering, and applications	6
Scalemic natural products	6
Front cover	5
Natural products targeting the metabolism of amino acids: from discovery to synthetic development	5
S-Adenosylmethionine: more than just a methyl donor	5
Back cover	5
Contents list	5
Contents list	5
Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies	5
Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential – a review	5
Cultivar to chemotype: characterizing complex botanicals with mass spectrometry metabolomics	5
Hot off the Press	5
Microbial natural products activated by plant stress	5
para-Quinone methides in natural product biosynthesis	4
Antarctic bacterial natural products: from genomic insights to drug discovery	4
Contents list	4
Controllable skeletal reorganizations in natural product synthesis	4
Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri	4
Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential	4
Back cover	4
Medium-sized peptides from microbial sources with potential for antibacterial drug development	4
Natural ten-membered lactones: sources, structural diversity, biological activity, and intriguing future	4
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study	4
Huperzine alkaloids: forty years of total syntheses	4
Discovery, structure revision, synthesis, and application of all known and even unknown securingine alkaloids	4
Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications	4
Polyamine-containing natural products: structure, bioactivity, and biosynthesis	3
Back cover	3
The cytochalasans: potent fungal natural products with application from bench to bedside	3
Back cover	3
Dietary substances and their glucuronides: structures, occurrence and biological activity	3
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides	3
Natural products from plants targeting key enzymes for the future development of antidiabetic agents	3
Front cover	3
Isolation and synthesis of bisabosquals, fungal triprenyl phenol meroterpenoids with a densely functionalised bisabolane core	3
Contents list	2
Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics	2
Hot off the Press	2
Front cover	2
Back cover	2
Recent highlights of the total synthesis of cyclic peptide natural products	2
β-Lactam antibiotics and β-lactamases: historical perspectives and a review of β-lactamase inhibitors derived from natural products	2
Microbial skeletal editing: hints for arene reconstruction from actinobacteria	2
Contents list	2
Marine natural products	2
Hot off the press	2
Diversity of enzymatic SAM-dependent C -methylation of aromatic compounds	2
Chemistry and biology of specialized metabolites produced by Actinomadura	2
Back cover	2
Regulation of daptomycin biosynthesis in Streptomyces roseosporus: new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production	2