Natural Product Reports

Article	Citations
Privileged natural product compound classes for anti-inflammatory drug development	218
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	194
Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis	156
Silybin and its congeners: from traditional medicine to molecular effects	147
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	141
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	118
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	117
Harnessing microbial co-culture to increase the production of known secondary metabolites	117
Biosynthesis, regulation, and engineering of natural products from Lysobacter	111
Inside front cover	111
Front cover	108
Back cover	96
Introduction to engineering the biosynthesis of fungal natural products	94
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products	92
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	88
Medicinal plant resin natural products: structural diversity and biological activities	87
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	85
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	82
Streptomyces cell-free systems for natural product discovery and engineering	82
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	81
Discovery, bioactivity and biosynthesis of fungal piperazines	77
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	77
Front cover	74
Inside front cover	72
Correction: Dearomative logic in natural product total synthesis	69

Streptomyces as a versatile host platform for heterologous production of microbial natural products	68
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	67
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	67
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	65
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	65
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	63
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	60
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	59
Contents list	56
Enzymatic ester bond formation strategies in fungal macrolide skeletons	56
Marine natural products	55
Back cover	53
Chemoenzymatic approaches to plant natural product inspired compounds	53
Front cover	52
Contents list	52
Contents list	51
Contents list	49
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	48
Image to insight: exploring natural products through mass spectrometry imaging	47
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	46
Synthetic-bioinformatic natural product-inspired peptides	46
Biosynthesis of fungal terpenoids	46
Inside front cover	46
Front cover	45
Front cover	45
Contents list	45
Illuminating the dark space of bioactive peptides with mass spectrometry	44
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	43
Strategies for the synthesis ofStemonaalkaloids: an update	42
Back cover	42
Technological developments driving industrial natural product discovery	41
Back cover	41
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	41
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	40
Hot off the Press	40
Enzymatic crosslinking of histidine side chains in peptide natural products	39
Back cover	39
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	39
Inside front cover	38
Back cover	38
Back cover	37
Hot off the Press	37
Contents list	37
Contents list	36
Back cover	36
Synthesis of rearranged indole diterpenes of the paxilline type	35
Engineering the biosynthesis of fungal nonribosomal peptides	35
Front cover	35
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	34
Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches	34

Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	34
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	34
Biosynthesis of invertebrate-derived natural products: an uncharted territory	33
AI and mechanistic modeling for characterizing biosynthetic pathways of natural products	33
Recent advances in oxidative phenol coupling for the total synthesis of natural products	33
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	33
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	32
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	32
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	31
Back cover	31
The shikimate pathway: gateway to metabolic diversity	31
Contents list	31
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	30
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	30
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	30
Natural products as anthelmintics: safeguarding animal health	30
Semi-synthesis in the exploration of opioid-targeting natural products	29
Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis	29
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	29
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	29
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	28
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	28
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	28
Front cover	28
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	28
Analytical methods for the analysis of volatile natural products	27
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	27
Back cover	27
Contents list	27
Contents list	27
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	27
Biosynthesis and bioactivities of microbial genotoxin colibactins	27
Contents list	27
Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions	26
The action of phytochemicals in biofilm control	26
Warfare under the waves: a review of bacteria-derived algaecidal natural products	26
The chemical and biological properties of natural resorcylic acid lactones	26
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	25
Opportunities and challenges of RiPP-based therapeutics	25
Contents list	25
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	25
Contents list	24
Back cover	24
Front cover	24
Back cover	23
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	23
Contents list	23
Egg toxic compounds in the animal kingdom. A comprehensive review	23
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	22
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	22
Intramolecular cycloaddition of nitrones in total synthesis of natural products	22
The development of Burkholderia bacteria as heterologous hosts	22
A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids	22
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	21
Specialized metabolite modifications in Brassicaceae seeds and plants: diversity, functions and related enzymes	21
40 Years of Natural Product Reports	21
Contents list	21
Challenges and opportunities for cheat therapy in the control of bacterial infections	21
The bisintercalator family of nonribosomal peptides: structural diversity and biosynthetic mechanism	21
Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth	20
Rotenoid diversity, distribution and evolution in plant lineages	19
Inside front cover	19
Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products	19
The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism	19
Back cover	18
Back cover	18
Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases	18
Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer	18
Front cover	18
Contents list	18
Contents list	18
Introduction to volatile natural products	17
Inside front cover	17
Anthracyclines: biosynthesis, engineering and clinical applications	17
Picrotoxane sesquiterpenoids: chemistry, chemo- and bio-syntheses and biological activities	17
Contents list	17
Front cover	16
Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)	16
Correction: Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids	15
Trends in metabolite discovery from Actinomycetes	15

Natural product inspired antibiotics approved for human use – 1943 to 2025	15
Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis	15
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022	15
Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers	14
Advances in the discovery and study of Trichoderma natural products for biological control applications	14
Engineering fungal terpene biosynthesis	14
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria	14
Embracing the era of antimicrobial peptides with marine organisms	14
Biosynthesis of pyrroloindoline-containing natural products	14
Back cover	13
Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides	13
Back cover	13
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	13
Chemistry and biology of natural stilbenes: an update	12
Natural products influence bacteriophage infectivity	12
Hot off the Press	12
Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners	12
Back cover	12
Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis	12
Bioactive natural products from Bacteroidetes	12
Organic synthesis in the study of terpene-derived oxidation products in the atmosphere	12
Engineering class I terpene synthases for skeletal diversity: strategies and applications	12
Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states	12
Chemical diversity of cyanobacterial natural products	11
Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites	11
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives	11
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature	11
Meroterpenoids? A historical and critical review of this biogenetic determinant	11
Accelerating enzyme discovery and engineering with high-throughput screening	11
The Kornblum DeLaMare rearrangement in natural product synthesis: 25 years of innovation	11
Extraction techniques for bioactive compounds of cannabis	11
Scaling up for success: from bioactive natural products to new medicines	11
Back cover	11
Inside front cover	11
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design	10
Scalemic natural products	10
The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis	10
Fe(ii) and 2-oxoglutarate-dependent dioxygenases for natural product synthesis: molecular insights into reaction diversity	10
Halogenases and dehalogenases: mechanisms, engineering, and applications	10
Front cover	10
Microbial polyketides and their roles in insect virulence: from genomics to biological functions	10
Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ	10
Hot off the Press	9
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)	9
Cultivar to chemotype: characterizing complex botanicals with mass spectrometry metabolomics	9
Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers	9
Contents list	9
Contents list	8
Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies	8
S-Adenosylmethionine: more than just a methyl donor	8
Hot off the Press	8
Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications	8
Back cover	8
Contents list	8
Natural ten-membered lactones: sources, structural diversity, biological activity, and intriguing future	8
Antarctic bacterial natural products: from genomic insights to drug discovery	8
Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential – a review	8
Front cover	8
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study	8
para-Quinone methides in natural product biosynthesis	7
Recent advances in the synthesis of ent-kaurane diterpenoids	7
Huperzine alkaloids: forty years of total syntheses	7
Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri	6
Integrative omics approaches for biosynthetic pathway discovery in plants	6
Natural products targeting the metabolism of amino acids: from discovery to synthetic development	6
Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2,5-dioxopiperazines	6
Contents list	6
The phosphate ester group in secondary metabolites	6
Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential	6
Plant-based engineering for production of high-valued natural products	6
Back cover	5
Anti-mycobacterial natural products and mechanisms of action	5
Alternative metabolic pathways and strategies to high-titre terpenoid production inEscherichia coli	5
Controllable skeletal reorganizations in natural product synthesis	5
Discovery, structure revision, synthesis, and application of all known and even unknown securingine alkaloids	5
Polyamine-containing natural products: structure, bioactivity, and biosynthesis	5
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides	5
Front cover	5
Dietary substances and their glucuronides: structures, occurrence and biological activity	5
Harnessing intercellular signals to engineer the soil microbiome	5
Natural products from plants targeting key enzymes for the future development of antidiabetic agents	5
Back cover	4
Chemistry and biology of specialized metabolites produced by Actinomadura	4
Hot off the press	4
Contents list	4
The cytochalasans: potent fungal natural products with application from bench to bedside	4
Back cover	4
Medium-sized peptides from microbial sources with potential for antibacterial drug development	4
Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae	4
Front cover	4
Back cover	4
Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics	4
Microbial skeletal editing: hints for arene reconstruction from actinobacteria	4
Front cover	3
Front cover	3