Natural Product Reports

Papers
(The median citation count of Natural Product Reports is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)
ArticleCitations
New developments in RiPP discovery, enzymology and engineering471
Marine natural products261
Marine natural products166
Marine natural products117
The scaffold-forming steps of plant alkaloid biosynthesis115
Natural products in agarwood andAquilariaplants: chemistry, biological activities and biosynthesis109
Cytochrome P450 enzymes in fungal natural product biosynthesis108
A roadmap for metagenomic enzyme discovery96
Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches96
Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities95
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide92
Bacterial terpenome91
Triptolide: reflections on two decades of research and prospects for the future91
Traditional Chinese medicine (TCM) as a source of new anticancer drugs83
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities76
Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.75
Genome mining methods to discover bioactive natural products75
Terpenoids from the medicinal mushroomAntrodia camphorata: chemistry and medicinal potential69
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis67
Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota66
Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy65
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis64
Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology63
Machine learning approaches for elucidating the biological effects of natural products63
Solanum steroidal glycoalkaloids: structural diversity, biological activities, and biosynthesis62
Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits61
Anthracyclines: biosynthesis, engineering and clinical applications60
Microbial natural product databases: moving forward in the multi-omics era58
Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products57
Biosynthesis, evolution and ecology of microbial terpenoids56
Regio- and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis56
Fungal–fungal co-culture: a primer for generating chemical diversity54
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos54
The year 2020 in natural product bioinformatics: an overview of the latest tools and databases51
Enzymatic dimerization in the biosynthetic pathway of microbial natural products51
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis51
The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs50
How different are marine microbial natural products compared to their terrestrial counterparts?47
Alternative metabolic pathways and strategies to high-titre terpenoid production inEscherichia coli46
Biosynthesis of azaphilones: a review46
Biosynthesis of cyclopropane in natural products45
Marine paralytic shellfish toxins: chemical properties, mode of action, newer analogues, and structure–toxicity relationship45
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis45
Naturally occurring prenylated chalcones from plants: structural diversity, distribution, activities and biosynthesis44
Chemistry of fungal meroterpenoid cyclases44
Natural product C-glycosyltransferases – a scarcely characterised enzymatic activity with biotechnological potential44
Advancements in capturing and mining mass spectrometry data are transforming natural products research44
Unlocking the potential of marine biodiscovery43
Skipped dienes in natural product synthesis42
Sesterterpenoids: chemistry, biology, and biosynthesis42
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)41
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses41
Structure–function relationship of terpenoid glycosyltransferases from plants40
Research progress of meliaceous limonoids from 2011 to 202140
The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis39
Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products39
Multi-colored shades of betalains: recent advances in betacyanin chemistry38
Cytotoxic and antitumor peptides as novel chemotherapeutics38
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded inStreptomycesgenomes38
Bottromycins - biosynthesis, synthesis and activity38
Tropane alkaloid biosynthesis: a centennial review37
Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons36
Natural withanolides, an update35
Dearomative logic in natural product total synthesis35
The chemical ecology of the fungus-farming termite symbiosis35
The beauty of biocatalysis: sustainable synthesis of ingredients in cosmetics35
Plant biosynthetic gene clusters in the context of metabolic evolution35
MicroED in natural product and small molecule research35
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic34
Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria34
The confluence of big data and evolutionary genome mining for the discovery of natural products34
Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)34
Ring systems in natural products: structural diversity, physicochemical properties, and coverage by synthetic compounds33
The chemistry and biology of guanidine secondary metabolites33
Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds33
Cheminformatic analysis of natural product-based drugs and chemical probes33
Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity33
Biosynthesis of pyrroloindoline-containing natural products32
Ribosomally synthesized peptides, foreground players in microbial interactions: recent developments and unanswered questions32
The application potential of machine learning and genomics for understanding natural product diversity, chemistry, and therapeutic translatability32
Recent advances in the synthesis of ent-kaurane diterpenoids32
N,C-Coupled naphthylisoquinoline alkaloids: a versatile new class of axially chiral natural products31
Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases31
Image to insight: exploring natural products through mass spectrometry imaging30
Integrative omics approaches for biosynthetic pathway discovery in plants30
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design29
The synthesis of biologically active indolocarbazole natural products29
Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining29
S-Adenosylmethionine: more than just a methyl donor29
Biosynthesis and heterologous production of furanocoumarins: perspectives and current challenges28
Silybin and its congeners: from traditional medicine to molecular effects28
Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)27
Balancing skeleton and functional groups in total syntheses of complex natural products: a case study of tigliane, daphnane and ingenane diterpenoids27
Artificial intelligence in microbial natural product drug discovery: current and emerging role26
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature25
Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation25
Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi24
Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces24
Molecules derived from the extremes of life: a decade later24
Anthraquinone-fused enediynes: discovery, biosynthesis and development24
Streptomyces cell-free systems for natural product discovery and engineering24
Trends of antimalarial marine natural products: progresses, challenges and opportunities23
Polypharmacology of andrographolide: beyond one molecule one target23
Polyketide β-branching: diversity, mechanism and selectivity23
Engineering the biosynthesis of fungal nonribosomal peptides22
Marine natural products22
Study towards improving artemisinin-based combination therapies22
Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism22
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions21
Selaginellins from the genusSelaginella: isolation, structure, biological activity, and synthesis21
Microbial engineering for the production of C2–C6organic acids21
Bioactive natural products from Bacteroidetes20
Chemical labeling strategies for small molecule natural product detection and isolation20
The tryptophan connection: cyclic peptide natural products linkedviathe tryptophan side chain20
Predicting biochemical and physiological effects of natural products from molecular structures using machine learning20
Biosynthetic strategies for tetramic acid formation20
A straightforward access to trifluoromethylated natural products through late-stage functionalization20
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives20
Cryptic halogenation reactions in natural product biosynthesis20
The isolation of water-soluble natural products – challenges, strategies and perspectives20
Out for a RiPP: challenges and advances in genome mining of ribosomal peptides from fungi19
Engineering yeast for the production of plant terpenoids using synthetic biology approaches19
Cis double bond formation in polyketide biosynthesis19
Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae19
Recent advances in total syntheses of natural products containing the benzocycloheptane motif19
Heck macrocyclization in natural product total synthesis18
The need to innovate sample collection and library generation in microbial drug discovery: a focus on academia18
Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis18
Site-directed mutagenesis and substrate compatibility to reveal the structure–function relationships of plant oxidosqualene cyclases18
The action of phytochemicals in biofilm control18
Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners18
Anti-mycobacterial natural products and mechanisms of action18
Strategies for total synthesis of bispyrrolidinoindoline alkaloids18
Plant glycosyltransferases for expanding bioactive glycoside diversity17
ent-Atisane diterpenoids: isolation, structure and bioactivity17
Needles in haystacks: reevaluating old paradigms for the discovery of bacterial secondary metabolites17
Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis17
The chemistry of mavacurane alkaloids: a rich source of bis-indole alkaloids17
Recent advances in oxidative phenol coupling for the total synthesis of natural products16
Fungal bioactive macrolides16
Optical sensor arrays for the detection and discrimination of natural products16
The ‘emodin family’ of fungal natural products–amalgamating a century of research with recent genomics-based advances16
Recent advances on marine mollusk-derived natural products: chemistry, chemical ecology and therapeutical potential16
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host15
Embracing the era of antimicrobial peptides with marine organisms15
The shikimate pathway: gateway to metabolic diversity15
Corallopyronin A: antimicrobial discovery to preclinical development15
Chemoenzymatic approaches to plant natural product inspired compounds15
On the evolution of coenzyme biosynthesis15
Extraction techniques for bioactive compounds of cannabis15
Biosynthesis and bioactivities of microbial genotoxin colibactins15
Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics14
Enzymatic macrocyclization of ribosomally synthesized and posttranslational modified peptidesviaC–S and C–C bond formation14
Engineering fungal terpene biosynthesis14
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes14
Dynamic environmental interactions shaped by vegetative plant volatiles14
Fungal benzene carbaldehydes: occurrence, structural diversity, activities and biosynthesis14
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–202214
Plant-based engineering for production of high-valued natural products14
Benefiting from big data in natural products: importance of preserving foundational skills and prioritizing data quality14
Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring14
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases14
Differences in diterpenoid diversity reveal new evidence for separating the genus Coleus from Plectranthus13
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)13
Plant (di)terpenoid evolution: from pigments to hormones and beyond13
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?13
Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity ofGanodermameroterpenoids13
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products13
Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers13
The phosphate ester group in secondary metabolites13
Recent ring distortion reactions for diversifying complex natural products13
The chromodepsins – chemistry, biology and biosynthesis of a selective Gq inhibitor natural product family13
Modifications, biological origin and antibacterial activity of naphthalenoid ansamycins13
Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2,5-dioxopiperazines13
Biosynthesis, regulation, and engineering of natural products from Lysobacter13
Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review12
Picrotoxane sesquiterpenoids: chemistry, chemo- and bio-syntheses and biological activities12
Functions and biosynthesis of plant signaling metabolites mediating plant–microbe interactions12
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes12
Biogenetic and biomimetic synthesis of natural bisditerpenoids: hypothesis and practices11
Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses11
The expanding CRISPR toolbox for natural product discovery and engineering in filamentous fungi11
Synthesis of rearranged indole diterpenes of the paxilline type11
Recent advances in gut microbiota-associated natural products: structures, bioactivities, and mechanisms11
The coenzyme/protein pair and the molecular evolution of life11
From plant to cancer drug: lessons learned from the discovery of taxol11
Biosynthesis of fungal terpenoids11
Natural products acting against S. aureus through membrane and cell wall disruption11
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis10
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming10
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals10
Leveraging orthogonal mass spectrometry based strategies for comprehensive sequencing and characterization of ribosomal antimicrobial peptide natural products10
Tailoring enzyme strategies and functional groups in biosynthetic pathways10
Natural sesquiterpene quinone/quinols: chemistry, biological activity, and synthesis10
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems9
Oligodendroglial glycolipids in (Re)myelination: implications for multiple sclerosis research9
Recent advances in the synthesis of natural products containing the phloroglucinol motif9
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis9
Natural products from plants targeting key enzymes for the future development of antidiabetic agents9
Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri9
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide9
Meroterpenoids? A historical and critical review of this biogenetic determinant9
Machine learning-assisted structure annotation of natural products based on MS and NMR data9
Discovery, bioactivity and biosynthesis of fungal piperazines9
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis8
Strychnine and its mono- and dimeric analogues: a pharmaco-chemical perspective8
Brief overview of recently reported misassigned natural products and their in silico revisions enabled by DU8ML, a machine learning-augmented DFT computational NMR method8
Dehydroamino acid residues in bioactive natural products8
Signalling molecules inducing metamorphosis in marine organisms8
Harnessing the potential: advances in cyanobacterial natural product research and biotechnology7
Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases7
Revisiting the manzamine biosynthetic hypothesis7
From solo to duet, intersections of natural product assembly with self-resistance7
Future antimalarials fromArtemisia? A rationale for natural product mining against drug-refractoryPlasmodiumstages7
Synthetic strategies for the ibophyllidine alkaloids7
The volatile chemistry of orchid pollination7
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria7
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study7
An invocation for computational evaluation of isomerization transforms: cationic skeletal reorganizations as a case study7
Discovery, synthesis, activities, structure–activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive review6
Microbial polyketides and their roles in insect virulence: from genomics to biological functions6
Bacterial cyclophane-containing RiPPs from radical SAM enzymes6
Class II terpene cyclases: structures, mechanisms, and engineering6
A chemoinformatic analysis on natural glycosides with respect to biological origin and structural class6
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 20226
Building trans-bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic development6
Rhazinilam–leuconolam family of natural products: a half century of total synthesis6
Recent strategies and tactics for the enantioselective total syntheses of cyclolignan natural products6
The scent chemistry of butterflies6
Controllable skeletal reorganizations in natural product synthesis5
Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential – a review5
Strategies for the synthesis ofStemonaalkaloids: an update5
Opportunities and challenges of RiPP-based therapeutics5
The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism4
Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis4
Therapeutic vulnerabilities of cancer stem cells and effects of natural products4
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides4
Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer4
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids4
Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers4
Artemisinin as a therapeutic vs. its more complex Artemisia source material4
The role of Caenorhabditis elegans in the discovery of natural products for healthy aging4
Introduction to engineering the biosynthesis of fungal natural products4
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