Natural Product Reports

Article	Citations
New developments in RiPP discovery, enzymology and engineering	471
Marine natural products	261
Marine natural products	166
Marine natural products	117
The scaffold-forming steps of plant alkaloid biosynthesis	115
Natural products in agarwood andAquilariaplants: chemistry, biological activities and biosynthesis	109
Cytochrome P450 enzymes in fungal natural product biosynthesis	108
A roadmap for metagenomic enzyme discovery	96
Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches	96
Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities	95
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	92
Triptolide: reflections on two decades of research and prospects for the future	91
Bacterial terpenome	91
Traditional Chinese medicine (TCM) as a source of new anticancer drugs	83
Genome mining methods to discover bioactive natural products	77
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities	76
Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.	75
Terpenoids from the medicinal mushroomAntrodia camphorata: chemistry and medicinal potential	69
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	67
Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota	66
Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy	65
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	64
Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology	63
Machine learning approaches for elucidating the biological effects of natural products	63
Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits	62

Solanum steroidal glycoalkaloids: structural diversity, biological activities, and biosynthesis	62
Anthracyclines: biosynthesis, engineering and clinical applications	61
Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products	58
Microbial natural product databases: moving forward in the multi-omics era	58
Biosynthesis, evolution and ecology of microbial terpenoids	56
Regio- and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis	56
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos	54
Fungal–fungal co-culture: a primer for generating chemical diversity	54
Enzymatic dimerization in the biosynthetic pathway of microbial natural products	51
The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs	51
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis	51
The year 2020 in natural product bioinformatics: an overview of the latest tools and databases	51
How different are marine microbial natural products compared to their terrestrial counterparts?	47
Biosynthesis of azaphilones: a review	46
Alternative metabolic pathways and strategies to high-titre terpenoid production inEscherichia coli	46
Marine paralytic shellfish toxins: chemical properties, mode of action, newer analogues, and structure–toxicity relationship	46
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	45
Biosynthesis of cyclopropane in natural products	45
Chemistry of fungal meroterpenoid cyclases	44
Natural product C-glycosyltransferases – a scarcely characterised enzymatic activity with biotechnological potential	44
Naturally occurring prenylated chalcones from plants: structural diversity, distribution, activities and biosynthesis	44
Advancements in capturing and mining mass spectrometry data are transforming natural products research	44
Unlocking the potential of marine biodiscovery	43
Skipped dienes in natural product synthesis	42
Sesterterpenoids: chemistry, biology, and biosynthesis	42
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	41
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)	41
Research progress of meliaceous limonoids from 2011 to 2021	40
Structure–function relationship of terpenoid glycosyltransferases from plants	40
The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis	39
Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products	39
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded inStreptomycesgenomes	38
Bottromycins - biosynthesis, synthesis and activity	38
Multi-colored shades of betalains: recent advances in betacyanin chemistry	38
Cytotoxic and antitumor peptides as novel chemotherapeutics	38
Plant biosynthetic gene clusters in the context of metabolic evolution	37
Tropane alkaloid biosynthesis: a centennial review	37
Ring systems in natural products: structural diversity, physicochemical properties, and coverage by synthetic compounds	36
Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons	36
MicroED in natural product and small molecule research	35
Dearomative logic in natural product total synthesis	35
The chemical ecology of the fungus-farming termite symbiosis	35
The beauty of biocatalysis: sustainable synthesis of ingredients in cosmetics	35
Natural withanolides, an update	35
The confluence of big data and evolutionary genome mining for the discovery of natural products	34
Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)	34
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	34
Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria	34
Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity	33
Cheminformatic analysis of natural product-based drugs and chemical probes	33

Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds	33
The chemistry and biology of guanidine secondary metabolites	33
Biosynthesis of pyrroloindoline-containing natural products	32
N,C-Coupled naphthylisoquinoline alkaloids: a versatile new class of axially chiral natural products	32
Image to insight: exploring natural products through mass spectrometry imaging	32
Recent advances in the synthesis of ent-kaurane diterpenoids	32
The application potential of machine learning and genomics for understanding natural product diversity, chemistry, and therapeutic translatability	32
Ribosomally synthesized peptides, foreground players in microbial interactions: recent developments and unanswered questions	32
Integrative omics approaches for biosynthetic pathway discovery in plants	31
Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases	31
The synthesis of biologically active indolocarbazole natural products	29
S-Adenosylmethionine: more than just a methyl donor	29
Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining	29
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design	29
Silybin and its congeners: from traditional medicine to molecular effects	28
Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces	28
Biosynthesis and heterologous production of furanocoumarins: perspectives and current challenges	28
Balancing skeleton and functional groups in total syntheses of complex natural products: a case study of tigliane, daphnane and ingenane diterpenoids	27
Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)	27
Artificial intelligence in microbial natural product drug discovery: current and emerging role	26
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature	25
Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation	25
Anthraquinone-fused enediynes: discovery, biosynthesis and development	24
Streptomyces cell-free systems for natural product discovery and engineering	24
Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi	24
Molecules derived from the extremes of life: a decade later	24
Polypharmacology of andrographolide: beyond one molecule one target	23
Polyketide β-branching: diversity, mechanism and selectivity	23
Trends of antimalarial marine natural products: progresses, challenges and opportunities	23
Study towards improving artemisinin-based combination therapies	22
Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism	22
Engineering the biosynthesis of fungal nonribosomal peptides	22
Marine natural products	22
Selaginellins from the genusSelaginella: isolation, structure, biological activity, and synthesis	21
Microbial engineering for the production of C2–C6organic acids	21
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	21
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives	20
Chemical labeling strategies for small molecule natural product detection and isolation	20
The isolation of water-soluble natural products – challenges, strategies and perspectives	20
Bioactive natural products from Bacteroidetes	20
Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae	20
Cryptic halogenation reactions in natural product biosynthesis	20
A straightforward access to trifluoromethylated natural products through late-stage functionalization	20
Predicting biochemical and physiological effects of natural products from molecular structures using machine learning	20
Biosynthetic strategies for tetramic acid formation	20
The tryptophan connection: cyclic peptide natural products linkedviathe tryptophan side chain	20
Engineering yeast for the production of plant terpenoids using synthetic biology approaches	19
Recent advances in total syntheses of natural products containing the benzocycloheptane motif	19
Out for a RiPP: challenges and advances in genome mining of ribosomal peptides from fungi	19
Cis double bond formation in polyketide biosynthesis	19
Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis	18
Site-directed mutagenesis and substrate compatibility to reveal the structure–function relationships of plant oxidosqualene cyclases	18
The action of phytochemicals in biofilm control	18
Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners	18
Anti-mycobacterial natural products and mechanisms of action	18
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	18
Heck macrocyclization in natural product total synthesis	18
The need to innovate sample collection and library generation in microbial drug discovery: a focus on academia	18
Needles in haystacks: reevaluating old paradigms for the discovery of bacterial secondary metabolites	17
Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis	17
The chemistry of mavacurane alkaloids: a rich source of bis-indole alkaloids	17
Plant glycosyltransferases for expanding bioactive glycoside diversity	17
ent-Atisane diterpenoids: isolation, structure and bioactivity	17
Optical sensor arrays for the detection and discrimination of natural products	16
The ‘emodin family’ of fungal natural products–amalgamating a century of research with recent genomics-based advances	16
Recent advances on marine mollusk-derived natural products: chemistry, chemical ecology and therapeutical potential	16
Recent advances in oxidative phenol coupling for the total synthesis of natural products	16
Fungal bioactive macrolides	16
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	15
The shikimate pathway: gateway to metabolic diversity	15
Chemoenzymatic approaches to plant natural product inspired compounds	15
Corallopyronin A: antimicrobial discovery to preclinical development	15
On the evolution of coenzyme biosynthesis	15
Biosynthesis and bioactivities of microbial genotoxin colibactins	15
Extraction techniques for bioactive compounds of cannabis	15
Embracing the era of antimicrobial peptides with marine organisms	15
Plant-based engineering for production of high-valued natural products	14
Benefiting from big data in natural products: importance of preserving foundational skills and prioritizing data quality	14
Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring	14
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases	14

Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics	14
Enzymatic macrocyclization of ribosomally synthesized and posttranslational modified peptidesviaC–S and C–C bond formation	14
Engineering fungal terpene biosynthesis	14
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	14
Dynamic environmental interactions shaped by vegetative plant volatiles	14
Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity ofGanodermameroterpenoids	14
Fungal benzene carbaldehydes: occurrence, structural diversity, activities and biosynthesis	14
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022	14
The chromodepsins – chemistry, biology and biosynthesis of a selective Gq inhibitor natural product family	13
Modifications, biological origin and antibacterial activity of naphthalenoid ansamycins	13
Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2,5-dioxopiperazines	13
Recent ring distortion reactions for diversifying complex natural products	13
Differences in diterpenoid diversity reveal new evidence for separating the genus Coleus from Plectranthus	13
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	13
Plant (di)terpenoid evolution: from pigments to hormones and beyond	13
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	13
Biosynthesis, regulation, and engineering of natural products from Lysobacter	13
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	13
Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers	13
The phosphate ester group in secondary metabolites	13
The expanding CRISPR toolbox for natural product discovery and engineering in filamentous fungi	13
Synthesis of rearranged indole diterpenes of the paxilline type	12
Functions and biosynthesis of plant signaling metabolites mediating plant–microbe interactions	12
Picrotoxane sesquiterpenoids: chemistry, chemo- and bio-syntheses and biological activities	12
Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review	12
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	12
Biogenetic and biomimetic synthesis of natural bisditerpenoids: hypothesis and practices	11
Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses	11
Biosynthesis of fungal terpenoids	11
The coenzyme/protein pair and the molecular evolution of life	11
From plant to cancer drug: lessons learned from the discovery of taxol	11
Recent advances in gut microbiota-associated natural products: structures, bioactivities, and mechanisms	11
Natural products acting against S. aureus through membrane and cell wall disruption	11
Tailoring enzyme strategies and functional groups in biosynthetic pathways	10
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	10
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	10
Natural sesquiterpene quinone/quinols: chemistry, biological activity, and synthesis	10
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	10
Leveraging orthogonal mass spectrometry based strategies for comprehensive sequencing and characterization of ribosomal antimicrobial peptide natural products	10
Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri	9
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	9
Meroterpenoids? A historical and critical review of this biogenetic determinant	9
Machine learning-assisted structure annotation of natural products based on MS and NMR data	9
Discovery, bioactivity and biosynthesis of fungal piperazines	9
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	9
Oligodendroglial glycolipids in (Re)myelination: implications for multiple sclerosis research	9
Recent advances in the synthesis of natural products containing the phloroglucinol motif	9
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	9
Natural products from plants targeting key enzymes for the future development of antidiabetic agents	9
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	8
Class II terpene cyclases: structures, mechanisms, and engineering	8
Brief overview of recently reported misassigned natural products and their in silico revisions enabled by DU8ML, a machine learning-augmented DFT computational NMR method	8
Strychnine and its mono- and dimeric analogues: a pharmaco-chemical perspective	8
Signalling molecules inducing metamorphosis in marine organisms	8
Dehydroamino acid residues in bioactive natural products	8
Harnessing the potential: advances in cyanobacterial natural product research and biotechnology	7
Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases	7
Revisiting the manzamine biosynthetic hypothesis	7
From solo to duet, intersections of natural product assembly with self-resistance	7
Future antimalarials fromArtemisia? A rationale for natural product mining against drug-refractoryPlasmodiumstages	7
Synthetic strategies for the ibophyllidine alkaloids	7
The volatile chemistry of orchid pollination	7
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria	7
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study	7
An invocation for computational evaluation of isomerization transforms: cationic skeletal reorganizations as a case study	7
Discovery, synthesis, activities, structure–activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive review	6
The scent chemistry of butterflies	6
Microbial polyketides and their roles in insect virulence: from genomics to biological functions	6
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	6
A chemoinformatic analysis on natural glycosides with respect to biological origin and structural class	6
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	6
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	6
Rhazinilam–leuconolam family of natural products: a half century of total synthesis	6
Recent strategies and tactics for the enantioselective total syntheses of cyclolignan natural products	6
Building trans-bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic development	6
Opportunities and challenges of RiPP-based therapeutics	5
Controllable skeletal reorganizations in natural product synthesis	5
Artemisinin as a therapeuticvs.its more complexArtemisiasource material	5
Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential – a review	5
Strategies for the synthesis ofStemonaalkaloids: an update	5
Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer	4
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	4
Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers	4
Organic synthesis in the study of terpene-derived oxidation products in the atmosphere	4
The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism	4
Introduction to engineering the biosynthesis of fungal natural products	4
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	4
Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis	4
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	4
Industrial total synthesis of natural medicines	3
Hot off the press	3
Cyanophycin and its biosynthesis: not hot but very cool	3
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	3
Analytical methods for the analysis of volatile natural products	3
Correction: Engineering strategies for rational polyketide synthase design	3