Natural Product Reports

Article	Citations
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	213
Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis	183
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	142
Biosynthesis, regulation, and engineering of natural products from Lysobacter	138
Privileged natural product compound classes for anti-inflammatory drug development	138
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	115
Harnessing microbial co-culture to increase the production of known secondary metabolites	113
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	106
Silybin and its congeners: from traditional medicine to molecular effects	105
Inside front cover	104
Front cover	94
Back cover	91
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	88
Streptomyces cell-free systems for natural product discovery and engineering	88
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	86
Introduction to engineering the biosynthesis of fungal natural products	82
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products	80
Discovery, bioactivity and biosynthesis of fungal piperazines	77
Medicinal plant resin natural products: structural diversity and biological activities	77
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	74
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	73
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	72
Front cover	71
Streptomyces as a versatile host platform for heterologous production of microbial natural products	66
Inside front cover	65

Enzymatic ester bond formation strategies in fungal macrolide skeletons	64
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	63
Correction: Dearomative logic in natural product total synthesis	61
Chemoenzymatic approaches to plant natural product inspired compounds	59
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	59
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	56
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	54
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	54
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	53
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	53
Marine natural products	52
Back cover	52
Front cover	50
Contents list	50
Contents list	49
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	48
Contents list	48
Synthetic-bioinformatic natural product-inspired peptides	45
Biosynthesis of fungal terpenoids	44
Image to insight: exploring natural products through mass spectrometry imaging	44
Front cover	43
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	43
Hot off the Press	42
Contents list	42
Front cover	41
Strategies for the synthesis ofStemonaalkaloids: an update	41
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	40
Illuminating the dark space of bioactive peptides with mass spectrometry	40
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	40
Back cover	39
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	39
Enzymatic crosslinking of histidine side chains in peptide natural products	38
Back cover	38
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	38
Inside front cover	37
Back cover	37
Back cover	37
Back cover	37
Technological developments driving industrial natural product discovery	37
Contents list	36
Hot off the Press	36
Contents list	35
Back cover	35
Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches	35
Recent advances in oxidative phenol coupling for the total synthesis of natural products	34
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	34
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	33
Synthesis of rearranged indole diterpenes of the paxilline type	33
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	33
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	32

Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	32
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	31
The shikimate pathway: gateway to metabolic diversity	31
Engineering the biosynthesis of fungal nonribosomal peptides	31
Contents list	30
Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis	30
Back cover	30
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	30
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	29
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	29
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	29
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	29
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	28
Semi-synthesis in the exploration of opioid-targeting natural products	28
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	28
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	28
Natural products as anthelmintics: safeguarding animal health	27
Front cover	27
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	27
Contents list	26
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	26
Contents list	26
Contents list	26
Back cover	26
The chemical and biological properties of natural resorcylic acid lactones	25
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	25
Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions	25
Opportunities and challenges of RiPP-based therapeutics	25
Warfare under the waves: a review of bacteria-derived algaecidal natural products	25
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	25
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	25
Analytical methods for the analysis of volatile natural products	25
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	24
The action of phytochemicals in biofilm control	24
Contents list	24
Biosynthesis and bioactivities of microbial genotoxin colibactins	24
Contents list	23
Back cover	23
Front cover	23
Intramolecular cycloaddition of nitrones in total synthesis of natural products	22
A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids	22
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	22
The development of Burkholderia bacteria as heterologous hosts	22
Egg toxic compounds in the animal kingdom. A comprehensive review	22
Back cover	22
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	22
Contents list	22
The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism	21
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	21
Challenges and opportunities for cheat therapy in the control of bacterial infections	21
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	21
40 Years of Natural Product Reports	20
The bisintercalator family of nonribosomal peptides: structural diversity and biosynthetic mechanism	20
Contents list	20
Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products	19
Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth	19
Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer	19
Contents list	18
Back cover	18
Specialized metabolite modifications in Brassicaceae seeds and plants: diversity, functions and related enzymes	18
Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases	18
Rotenoid diversity, distribution and evolution in plant lineages	18
Front cover	18
Contents list	17
Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)	16
Contents list	16
Engineering fungal terpene biosynthesis	16
Inside front cover	16
Trends in metabolite discovery from Actinomycetes	16
Back cover	16
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022	15
Picrotoxane sesquiterpenoids: chemistry, chemo- and bio-syntheses and biological activities	15
Embracing the era of antimicrobial peptides with marine organisms	15
Introduction to volatile natural products	15
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	15
Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers	14
Front cover	14
Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides	14
Correction: Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids	14
Anthracyclines: biosynthesis, engineering and clinical applications	14

Advances in the discovery and study of Trichoderma natural products for biological control applications	14
Biosynthesis of pyrroloindoline-containing natural products	13
Back cover	13
Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis	13
Back cover	13
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria	13
The Kornblum DeLaMare rearrangement in natural product synthesis: 25 years of innovation	12
Hot off the Press	12
Back cover	12
Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites	12
Natural products influence bacteriophage infectivity	12
Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis	11
Chemical diversity of cyanobacterial natural products	11
Accelerating enzyme discovery and engineering with high-throughput screening	11
Meroterpenoids? A historical and critical review of this biogenetic determinant	11
Organic synthesis in the study of terpene-derived oxidation products in the atmosphere	11
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature	11
Chemistry and biology of natural stilbenes: an update	11
Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers	10
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives	10
Scaling up for success: from bioactive natural products to new medicines	10
Inside front cover	10
Extraction techniques for bioactive compounds of cannabis	10
Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners	10
Front cover	10
Bioactive natural products from Bacteroidetes	10
Back cover	10
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)	9
Microbial polyketides and their roles in insect virulence: from genomics to biological functions	9
Hot off the Press	9
Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ	9
Fe(ii) and 2-oxoglutarate-dependent dioxygenases for natural product synthesis: molecular insights into reaction diversity	9
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design	9
The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis	9
Scalemic natural products	9
Contents list	8
S-Adenosylmethionine: more than just a methyl donor	8
Contents list	8
Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies	8
Front cover	8
Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential – a review	8
Contents list	8
Natural ten-membered lactones: sources, structural diversity, biological activity, and intriguing future	7
The phosphate ester group in secondary metabolites	7
Natural products targeting the metabolism of amino acids: from discovery to synthetic development	7
Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential	7
Antarctic bacterial natural products: from genomic insights to drug discovery	7
Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2,5-dioxopiperazines	7
Hot off the Press	7
Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri	6
Recent advances in the synthesis of ent-kaurane diterpenoids	6
para-Quinone methides in natural product biosynthesis	6
Front cover	6
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study	6
Plant-based engineering for production of high-valued natural products	6
Integrative omics approaches for biosynthetic pathway discovery in plants	6
Huperzine alkaloids: forty years of total syntheses	6
Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications	6
Contents list	6
Discovery, structure revision, synthesis, and application of all known and even unknown securingine alkaloids	5
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides	5
Polyamine-containing natural products: structure, bioactivity, and biosynthesis	5
Dietary substances and their glucuronides: structures, occurrence and biological activity	5
Medium-sized peptides from microbial sources with potential for antibacterial drug development	5
Harnessing intercellular signals to engineer the soil microbiome	5
Back cover	5
The cytochalasans: potent fungal natural products with application from bench to bedside	5
Controllable skeletal reorganizations in natural product synthesis	5
Anti-mycobacterial natural products and mechanisms of action	5
Back cover	4
Natural products from plants targeting key enzymes for the future development of antidiabetic agents	4
Hot off the press	4
Alternative metabolic pathways and strategies to high-titre terpenoid production inEscherichia coli	4
Back cover	4
Chemistry and biology of specialized metabolites produced by Actinomadura	4
Recent highlights of the total synthesis of cyclic peptide natural products	4
Front cover	4
Back cover	4
Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics	4
Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	3
Promoter engineering of natural product biosynthetic gene clusters in actinomycetes: concepts and applications	3
Corallopyronin A: antimicrobial discovery to preclinical development	3
Back cover	3
Regulation of daptomycin biosynthesis in Streptomyces roseosporus: new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production	3
Hot off the Press	3
Back cover	3
Contents list	3
Front cover	3
Empowering natural product science with AI: leveraging multimodal data and knowledge graphs	3
Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae	3
Hot off the Press	3
Front cover	3
Contents list	3