Natural Product Reports

Article	Citations
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	211
Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis	209
Harnessing microbial co-culture to increase the production of known secondary metabolites	160
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	148
Syntheses of furan natural products	112
Privileged natural product compound classes for anti-inflammatory drug development	103
Contents list	99
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	84
Inside front cover	78
Discovery, bioactivity and biosynthesis of fungal piperazines	70
Medicinal plant resin natural products: structural diversity and biological activities	69
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	66
Streptomyces cell-free systems for natural product discovery and engineering	65
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	62
Introduction to engineering the biosynthesis of fungal natural products	60
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	60
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	60
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products	55
Front cover	55
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	53
Inside front cover	53
Contents list	53
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	51
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	49
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	49

Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	48
Enzymatic ester bond formation strategies in fungal macrolide skeletons	48
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	46
Marine natural products	45
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	45
Highlights of cyanobacterial metabolites reported between 2021–2024	44
Charting the path for l -tyrosine derivatives: from engineering strategies to microbial cell factories	44
Streptomyces as a versatile host platform for heterologous production of microbial natural products	43
Front cover	43
Back cover	43
Contents list	43
Inside front cover	42
Contents list	42
Inside front cover	42
Editorial: Microbial host and metabolic engineering for natural product discovery and production	40
Synthetic-bioinformatic natural product-inspired peptides	40
Front cover	39
Contents list	38
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	38
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	37
Biosynthesis of fungal terpenoids	36
Recent advances in decoding biosynthetic pathways and synthetic biology approaches for plant alkaloids	36
Front cover	36
Hot off the Press	34
Illuminating the dark space of bioactive peptides with mass spectrometry	34
Back cover	34
Front cover	34
Front cover	34
Technological developments driving industrial natural product discovery	33
Back cover	33
Brief overview of recently reported misassigned natural products and their in silico revisions enabled by DU8ML, a machine learning-augmented DFT computa	33
Natural products modulating interleukin-mediated pathways for anti-allergic and immunomodulatory effects	32
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	32
Enzymatic crosslinking of histidine side chains in peptide natural products	31
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	31
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	31
From gene discovery to synthetic biology: recent advances in the biosynthesis of oleanane-type pentacyclic triterpenoids	30
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	29
Back cover	28
Contents list	27
Back cover	26
Hot off the Press	26
Front cover	25
Contents list	25
Engineering the biosynthesis of fungal nonribosomal peptides	25
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	25
Biosynthesis of invertebrate-derived natural products: an uncharted territory	25
Recent advances in oxidative phenol coupling for the total synthesis of natural products	24
Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches	24
AI and mechanistic modeling for characterizing biosynthetic pathways of natural products	24

Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	23
Back cover	23
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	23
Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis	23
The shikimate pathway: gateway to metabolic diversity	23
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	23
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	23
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	22
Semi-synthesis in the exploration of opioid-targeting natural products	22
Natural products as anthelmintics: safeguarding animal health	21
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	21
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	20
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	20
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	20
Contents list	20
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	20
Contents list	20
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	19
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	19
Contents list	19
Hot off the Press	18
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	18
Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions	18
Contents list	18
Warfare under the waves: a review of bacteria-derived algaecidal natural products	18
High-throughput assays for SAM-dependent methyltransferases: advances, challenges, and future perspectives	18
The action of phytochemicals in biofilm control	17
Opportunities and challenges of RiPP-based therapeutics	17
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	17
S -Adenosylmethionine: considerations on its role in the origin and evolution of life	17
Analytical methods for the analysis of volatile natural products	17
The chemical and biological properties of natural resorcylic acid lactones	17
Contents list	16
Back cover	16
Contents list	16
Contents list	16
Back cover	16
Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases	15
The development of Burkholderia bacteria as heterologous hosts	15
Specialized metabolite modifications in Brassicaceae seeds and plants: diversity, functions and related enzymes	15
A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids	15
40 Years of Natural Product Reports	15
Intramolecular cycloaddition of nitrones in total synthesis of natural products	15
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	15
Contents list	14
Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth	14
Inside front cover	14
Rotenoid diversity, distribution and evolution in plant lineages	14
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	14
Back cover	13
Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis	13
Engineering fungal terpene biosynthesis	13
Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer	13
Front cover	13
Inside front cover	13
Advances in the discovery and study of Trichoderma natural products for biological control applications	13
Front cover	13
Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products	13
Contents list	13
The bisintercalator family of nonribosomal peptides: structural diversity and biosynthetic mechanism	13
Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides	13
Contents list	13
Contents list	13
Introduction to volatile natural products	12
Trends in metabolite discovery from Actinomycetes	12
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022	12
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria	12
Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers	12
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	11
Natural product inspired antibiotics approved for human use – 1943 to 2025	11
Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)	11
Embracing the era of antimicrobial peptides with marine organisms	11
Back cover	10
Back cover	10
Hot off the Press	10
Back cover	10
Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states	9
Meroterpenoids? A historical and critical review of this biogenetic determinant	9
Scaling up for success: from bioactive natural products to new medicines	9
Accelerating enzyme discovery and engineering with high-throughput screening	9

Organic synthesis in the study of terpene-derived oxidation products in the atmosphere	9
Natural products influence bacteriophage infectivity	8
The Kornblum DeLaMare rearrangement in natural product synthesis: 25 years of innovation	8
Chemistry and biology of natural stilbenes: an update	8
Advancing natural product R&D&I: guide for compliance with responsible research and innovation, ethics, Nagoya and Cartagena Protocols, and intellectual property protection	8
Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites	8
Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis	8
Halogenases and dehalogenases: mechanisms, engineering, and applications	7
Chemical diversity of cyanobacterial natural products	7
Extraction techniques for bioactive compounds of cannabis	7
Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ	7
Engineering class I terpene synthases for skeletal diversity: strategies and applications	7
Scalemic natural products	7
The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis	7
Inside front cover	7
Back cover	7
Back cover	6
Fe(ii) and 2-oxoglutarate-dependent dioxygenases for natural product synthesis: molecular insights into reaction diversity	6
Contents list	6
Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers	6
Hot off the Press	6
Natural products targeting the metabolism of amino acids: from discovery to synthetic development	5
Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies	5
Back cover	5
Front cover	5
Contents list	5
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study	5
S-Adenosylmethionine: more than just a methyl donor	5
Skeleton innovation versus structural diversification in terpenoid discovery: chemoinformatic insights from TeroKit	5
Microbial natural products activated by plant stress	5
Hot off the Press	5
Contents list	5
Cultivar to chemotype: characterizing complex botanicals with mass spectrometry metabolomics	5
Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential – a review	5
Front cover	5
Natural ten-membered lactones: sources, structural diversity, biological activity, and intriguing future	4
Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential	4
Back cover	4
Huperzine alkaloids: forty years of total syntheses	4
Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri	4
Discovery, structure revision, synthesis, and application of all known and even unknown securingine alkaloids	4
Antarctic bacterial natural products: from genomic insights to drug discovery	4
Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications	4
Contents list	4
para-Quinone methides in natural product biosynthesis	4
Medium-sized peptides from microbial sources with potential for antibacterial drug development	3
Dietary substances and their glucuronides: structures, occurrence and biological activity	3
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides	3
Back cover	3
The cytochalasans: potent fungal natural products with application from bench to bedside	3
Controllable skeletal reorganizations in natural product synthesis	3
Isolation and synthesis of bisabosquals, fungal triprenyl phenol meroterpenoids with a densely functionalised bisabolane core	3
Back cover	3
Natural products from plants targeting key enzymes for the future development of antidiabetic agents	3
Polyamine-containing natural products: structure, bioactivity, and biosynthesis	3
Front cover	3
Contents list	2
Chemistry and biology of specialized metabolites produced by Actinomadura	2
Microbial skeletal editing: hints for arene reconstruction from actinobacteria	2
Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	2
β-Lactam antibiotics and β-lactamases: historical perspectives and a review of β-lactamase inhibitors derived from natural products	2
Recent highlights of the total synthesis of cyclic peptide natural products	2
Structural determination of natural products at speeds and scale of high-throughput screening	2
Back cover	2
Contents list	2
Hot off the press	2
Diversity of enzymatic SAM-dependent C -methylation of aromatic compounds	2
Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics	2
Hot off the Press	2