Natural Product Reports

Article	Citations
New developments in RiPP discovery, enzymology and engineering	392
Marine natural products	241
Marine natural products	137
The scaffold-forming steps of plant alkaloid biosynthesis	95
Natural products in agarwood andAquilariaplants: chemistry, biological activities and biosynthesis	84
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	80
Cytochrome P450 enzymes in fungal natural product biosynthesis	78
A roadmap for metagenomic enzyme discovery	76
Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches	74
Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities	72
Bacterial terpenome	71
Triptolide: reflections on two decades of research and prospects for the future	68
Marine natural products	65
Traditional Chinese medicine (TCM) as a source of new anticancer drugs	64
Genome mining methods to discover bioactive natural products	57
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities	55
Terpenoids from the medicinal mushroomAntrodia camphorata: chemistry and medicinal potential	55
Machine learning approaches for elucidating the biological effects of natural products	53
Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota	53
Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology	53
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	53
Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy	52
Microbial natural product databases: moving forward in the multi-omics era	50
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	50
Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.	49

Solanum steroidal glycoalkaloids: structural diversity, biological activities, and biosynthesis	45
The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs	44
Regio- and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis	44
The year 2020 in natural product bioinformatics: an overview of the latest tools and databases	43
Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products	43
Anthracyclines: biosynthesis, engineering and clinical applications	42
Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits	42
Enzymatic dimerization in the biosynthetic pathway of microbial natural products	42
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos	42
How different are marine microbial natural products compared to their terrestrial counterparts?	40
Biosynthesis of azaphilones: a review	39
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis	39
Biosynthesis, evolution and ecology of microbial terpenoids	38
Natural product C-glycosyltransferases – a scarcely characterised enzymatic activity with biotechnological potential	38
Alternative metabolic pathways and strategies to high-titre terpenoid production inEscherichia coli	37
Fungal–fungal co-culture: a primer for generating chemical diversity	37
Advancements in capturing and mining mass spectrometry data are transforming natural products research	36
Unlocking the potential of marine biodiscovery	36
Chemistry of fungal meroterpenoid cyclases	36
Sesterterpenoids: chemistry, biology, and biosynthesis	34
Skipped dienes in natural product synthesis	33
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded inStreptomycesgenomes	32
Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products	32
Multi-colored shades of betalains: recent advances in betacyanin chemistry	31
Tropane alkaloid biosynthesis: a centennial review	31
Biosynthesis of cyclopropane in natural products	31
Research progress of meliaceous limonoids from 2011 to 2021	31
MicroED in natural product and small molecule research	30
Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)	30
The chemistry and biology of guanidine secondary metabolites	30
Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds	29
Naturally occurring prenylated chalcones from plants: structural diversity, distribution, activities and biosynthesis	29
The application potential of machine learning and genomics for understanding natural product diversity, chemistry, and therapeutic translatability	29
The confluence of big data and evolutionary genome mining for the discovery of natural products	29
Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria	28
Bottromycins - biosynthesis, synthesis and activity	28
Marine paralytic shellfish toxins: chemical properties, mode of action, newer analogues, and structure–toxicity relationship	28
Structure–function relationship of terpenoid glycosyltransferases from plants	28
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)	27
Ribosomally synthesized peptides, foreground players in microbial interactions: recent developments and unanswered questions	27
Cytotoxic and antitumor peptides as novel chemotherapeutics	26
Recent advances in the synthesis of ent-kaurane diterpenoids	26
Cheminformatic analysis of natural product-based drugs and chemical probes	26
Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity	26
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	26
The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis	26
Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)	25
Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons	25
The chemical ecology of the fungus-farming termite symbiosis	25
The synthesis of biologically active indolocarbazole natural products	25

Natural withanolides, an update	25
The beauty of biocatalysis: sustainable synthesis of ingredients in cosmetics	24
N,C-Coupled naphthylisoquinoline alkaloids: a versatile new class of axially chiral natural products	23
Polyketide β-branching: diversity, mechanism and selectivity	22
Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases	22
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	21
Biosynthesis and heterologous production of furanocoumarins: perspectives and current challenges	21
Molecules derived from the extremes of life: a decade later	21
Selaginellins from the genusSelaginella: isolation, structure, biological activity, and synthesis	21
Polypharmacology of andrographolide: beyond one molecule one target	21
Biosynthesis of pyrroloindoline-containing natural products	20
Plant biosynthetic gene clusters in the context of metabolic evolution	20
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature	20
Image to insight: exploring natural products through mass spectrometry imaging	19
Dearomative logic in natural product total synthesis	19
Predicting biochemical and physiological effects of natural products from molecular structures using machine learning	19
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design	19
Ring systems in natural products: structural diversity, physicochemical properties, and coverage by synthetic compounds	18
Silybin and its congeners: from traditional medicine to molecular effects	18
Biosynthetic strategies for tetramic acid formation	18
The isolation of water-soluble natural products – challenges, strategies and perspectives	18
Chemical labeling strategies for small molecule natural product detection and isolation	18
Anthraquinone-fused enediynes: discovery, biosynthesis and development	17
Artificial intelligence in microbial natural product drug discovery: current and emerging role	17
Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism	17
Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi	17
Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation	17
Microbial engineering for the production of C2–C6organic acids	17
Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining	17
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	17
Integrative omics approaches for biosynthetic pathway discovery in plants	17
Cryptic halogenation reactions in natural product biosynthesis	16
Study towards improving artemisinin-based combination therapies	16
Balancing skeleton and functional groups in total syntheses of complex natural products: a case study of tigliane, daphnane and ingenane diterpenoids	16
Heck macrocyclization in natural product total synthesis	16
Recent advances in total syntheses of natural products containing the benzocycloheptane motif	15
Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces	15
The need to innovate sample collection and library generation in microbial drug discovery: a focus on academia	15
Fungal benzene carbaldehydes: occurrence, structural diversity, activities and biosynthesis	14
Cis double bond formation in polyketide biosynthesis	14
Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics	14
Engineering the biosynthesis of fungal nonribosomal peptides	14
Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners	14
The chemistry of mavacurane alkaloids: a rich source of bis-indole alkaloids	14
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives	14
Site-directed mutagenesis and substrate compatibility to reveal the structure–function relationships of plant oxidosqualene cyclases	14
Needles in haystacks: reevaluating old paradigms for the discovery of bacterial secondary metabolites	14
Bioactive natural products from Bacteroidetes	13
Trends of antimalarial marine natural products: progresses, challenges and opportunities	13
ent-Atisane diterpenoids: isolation, structure and bioactivity	13
Out for a RiPP: challenges and advances in genome mining of ribosomal peptides from fungi	13
Biosynthesis, regulation, and engineering of natural products from Lysobacter	13
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	13
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	13
Corallopyronin A: antimicrobial discovery to preclinical development	12
Anti-mycobacterial natural products and mechanisms of action	12
Streptomyces cell-free systems for natural product discovery and engineering	12
Enzymatic macrocyclization of ribosomally synthesized and posttranslational modified peptidesviaC–S and C–C bond formation	12
The chromodepsins – chemistry, biology and biosynthesis of a selective Gq inhibitor natural product family	12
Recent advances on marine mollusk-derived natural products: chemistry, chemical ecology and therapeutical potential	12
Chemoenzymatic approaches to plant natural product inspired compounds	12
Biosynthesis and bioactivities of microbial genotoxin colibactins	12
The tryptophan connection: cyclic peptide natural products linkedviathe tryptophan side chain	12
Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring	12
Modifications, biological origin and antibacterial activity of naphthalenoid ansamycins	12
S-Adenosylmethionine: more than just a methyl donor	12
A straightforward access to trifluoromethylated natural products through late-stage functionalization	12
Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis	11
Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review	11
Fungal bioactive macrolides	11
Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis	11
Benefiting from big data in natural products: importance of preserving foundational skills and prioritizing data quality	11
Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae	10
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	10
Engineering fungal terpene biosynthesis	10
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	10
Picrotoxane sesquiterpenoids: chemistry, chemo- and bio-syntheses and biological activities	9
The phosphate ester group in secondary metabolites	9
Functions and biosynthesis of plant signaling metabolites mediating plant–microbe interactions	9
Differences in diterpenoid diversity reveal new evidence for separating the genus Coleus from Plectranthus	9

Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses	9
Plant-based engineering for production of high-valued natural products	9
Synthesis of rearranged indole diterpenes of the paxilline type	9
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	9
Recent ring distortion reactions for diversifying complex natural products	9
The action of phytochemicals in biofilm control	8
Optical sensor arrays for the detection and discrimination of natural products	8
The coenzyme/protein pair and the molecular evolution of life	8
Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2,5-dioxopiperazines	8
On the evolution of coenzyme biosynthesis	8
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases	8
Leveraging orthogonal mass spectrometry based strategies for comprehensive sequencing and characterization of ribosomal antimicrobial peptide natural products	8
Plant glycosyltransferases for expanding bioactive glycoside diversity	8
Plant (di)terpenoid evolution: from pigments to hormones and beyond	8
Oligodendroglial glycolipids in (Re)myelination: implications for multiple sclerosis research	7
Biogenetic and biomimetic synthesis of natural bisditerpenoids: hypothesis and practices	7
Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri	7
The ‘emodin family’ of fungal natural products–amalgamating a century of research with recent genomics-based advances	7
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	7
Brief overview of recently reported misassigned natural products and their in silico revisions enabled by DU8ML, a machine learning-augmented DFT computational NMR method	7
Recent advances in the synthesis of natural products containing the phloroglucinol motif	7
Synthetic strategies for the ibophyllidine alkaloids	7
From solo to duet, intersections of natural product assembly with self-resistance	7
Signalling molecules inducing metamorphosis in marine organisms	7
Tailoring enzyme strategies and functional groups in biosynthetic pathways	7
Dynamic environmental interactions shaped by vegetative plant volatiles	7
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	7
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	6
An invocation for computational evaluation of isomerization transforms: cationic skeletal reorganizations as a case study	6
Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity ofGanodermameroterpenoids	6
Embracing the era of antimicrobial peptides with marine organisms	6
The expanding CRISPR toolbox for natural product discovery and engineering in filamentous fungi	6
Rhazinilam–leuconolam family of natural products: a half century of total synthesis	6
Natural sesquiterpene quinone/quinols: chemistry, biological activity, and synthesis	6
Engineering yeast for the production of plant terpenoids using synthetic biology approaches	5
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	5
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	5
Extraction techniques for bioactive compounds of cannabis	5
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	5
The scent chemistry of butterflies	5
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022	5
Recent strategies and tactics for the enantioselective total syntheses of cyclolignan natural products	5
Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers	4
Strychnine and its mono- and dimeric analogues: a pharmaco-chemical perspective	4
Meroterpenoids? A historical and critical review of this biogenetic determinant	4
Natural products from plants targeting key enzymes for the future development of antidiabetic agents	4
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	4
From plant to cancer drug: lessons learned from the discovery of taxol	4
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study	4
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	4
Natural products acting against S. aureus through membrane and cell wall disruption	3
Hot off the Press	3
Building trans-bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic development	3
Correction: Engineering strategies for rational polyketide synthase design	3
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	3
Recent advances in gut microbiota-associated natural products: structures, bioactivities, and mechanisms	3
Cyanophycin and its biosynthesis: not hot but very cool	3
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	3
Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer	3
Biosynthesis of cyclitols	3
Future antimalarials fromArtemisia? A rationale for natural product mining against drug-refractoryPlasmodiumstages	3
Hot off the press	3