Natural Product Reports

Article	Citations
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	195
Privileged natural product compound classes for anti-inflammatory drug development	159
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	119
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	117
Biosynthesis, regulation, and engineering of natural products from Lysobacter	93
Harnessing microbial co-culture to increase the production of known secondary metabolites	92
Silybin and its congeners: from traditional medicine to molecular effects	91
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	90
Front cover	87
Back cover	75
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	73
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	72
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	68
Discovery, bioactivity and biosynthesis of fungal piperazines	68
Streptomyces cell-free systems for natural product discovery and engineering	63
Medicinal plant resin natural products: structural diversity and biological activities	63
Introduction to engineering the biosynthesis of fungal natural products	63
Inside front cover	59
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	58
Correction: Dearomative logic in natural product total synthesis	58
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	54
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	52
Front cover	52
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	51
Chemoenzymatic approaches to plant natural product inspired compounds	49

Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	49
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	48
Marine natural products	48
Enzymatic ester bond formation strategies in fungal macrolide skeletons	47
Inside front cover	47
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	45
Front cover	44
Contents list	43
Contents list	43
Back cover	42
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	41
Contents list	41
Synthetic-bioinformatic natural product-inspired peptides	39
Image to insight: exploring natural products through mass spectrometry imaging	39
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	38
Biosynthesis of fungal terpenoids	37
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	37
Contents list	37
Hot off the Press	37
Front cover	36
Front cover	36
Illuminating the dark space of bioactive peptides with mass spectrometry	35
Enzymatic crosslinking of histidine side chains in peptide natural products	34
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	33
Strategies for the synthesis ofStemonaalkaloids: an update	33
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	33
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	32
Back cover	31
Inside front cover	30
Contents list	30
Back cover	30
Back cover	29
Hot off the Press	29
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	28
Synthesis of rearranged indole diterpenes of the paxilline type	28
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	28
Engineering the biosynthesis of fungal nonribosomal peptides	27
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	27
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	27
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	27
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	27
Recent advances in oxidative phenol coupling for the total synthesis of natural products	27
The shikimate pathway: gateway to metabolic diversity	27
Natural products as anthelmintics: safeguarding animal health	26
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	26
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	26
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	26
Contents list	25
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	25
Back cover	25

Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	24
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	24
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	24
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	23
Contents list	23
Front cover	23
Contents list	23
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	23
Back cover	23
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	22
Warfare under the waves: a review of bacteria-derived algaecidal natural products	22
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	22
Biosynthesis and bioactivities of microbial genotoxin colibactins	22
Opportunities and challenges of RiPP-based therapeutics	22
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	21
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	21
The action of phytochemicals in biofilm control	20
Contents list	20
Front cover	20
Analytical methods for the analysis of volatile natural products	20
Intramolecular cycloaddition of nitrones in total synthesis of natural products	20
Contents list	20
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	20
Egg toxic compounds in the animal kingdom. A comprehensive review	20
Back cover	19
Contents list	19
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	19
Back cover	19
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	18
Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products	18
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	18
Contents list	18
Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth	17
The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism	17
The bisintercalator family of nonribosomal peptides: structural diversity and biosynthetic mechanism	17
Specialized metabolite modifications in Brassicaceae seeds and plants: diversity, functions and related enzymes	17
40 Years of Natural Product Reports	17
Challenges and opportunities for cheat therapy in the control of bacterial infections	17
Front cover	16
Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases	16
Back cover	16
Back cover	16
Contents list	16
Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer	16
Inside front cover	15
Introduction to volatile natural products	15
Contents list	15
Contents list	15
Picrotoxane sesquiterpenoids: chemistry, chemo- and bio-syntheses and biological activities	15
Engineering fungal terpene biosynthesis	14
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria	14
Embracing the era of antimicrobial peptides with marine organisms	13
Correction: Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids	13
Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers	13
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	12
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022	12
Biosynthesis of pyrroloindoline-containing natural products	12
Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis	12
Anthracyclines: biosynthesis, engineering and clinical applications	12
Back cover	11
Organic synthesis in the study of terpene-derived oxidation products in the atmosphere	11
Back cover	11
Chemical diversity of cyanobacterial natural products	11
Back cover	11
Meroterpenoids? A historical and critical review of this biogenetic determinant	11
Chemistry and biology of natural stilbenes: an update	11
Scaling up for success: from bioactive natural products to new medicines	10
Bioactive natural products from Bacteroidetes	10
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature	10
Accelerating enzyme discovery and engineering with high-throughput screening	10
Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners	10
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives	10
Extraction techniques for bioactive compounds of cannabis	10
The Kornblum DeLaMare rearrangement in natural product synthesis: 25 years of innovation	10
Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites	10
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)	9
Back cover	9
Inside front cover	9
Front cover	9
The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis	9

Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design	8
Scalemic natural products	8
Fe(ii) and 2-oxoglutarate-dependent dioxygenases for natural product synthesis: molecular insights into reaction diversity	8
Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ	8
Microbial polyketides and their roles in insect virulence: from genomics to biological functions	8
Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers	8
S-Adenosylmethionine: more than just a methyl donor	7
The phosphate ester group in secondary metabolites	7
Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies	7
Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential – a review	7
Contents list	7
Hot off the Press	7
Contents list	7
Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri	6
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study	6
Plant-based engineering for production of high-valued natural products	6
Integrative omics approaches for biosynthetic pathway discovery in plants	6
Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2,5-dioxopiperazines	6
Natural ten-membered lactones: sources, structural diversity, biological activity, and intriguing future	6
Huperzine alkaloids: forty years of total syntheses	6
Hot off the Press	6
Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential	6
Antarctic bacterial natural products: from genomic insights to drug discovery	6
Recent advances in the synthesis of ent-kaurane diterpenoids	6
Natural products from plants targeting key enzymes for the future development of antidiabetic agents	5
Medium-sized peptides from microbial sources with potential for antibacterial drug development	5
Harnessing intercellular signals to engineer the soil microbiome	5
Controllable skeletal reorganizations in natural product synthesis	5
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides	5
The cytochalasans: potent fungal natural products with application from bench to bedside	5
Front cover	5
Alternative metabolic pathways and strategies to high-titre terpenoid production inEscherichia coli	5
Contents list	5
Polyamine-containing natural products: structure, bioactivity, and biosynthesis	5
Back cover	4
Back cover	4
Hot off the press	4
Back cover	4
Front cover	4
Chemistry and biology of specialized metabolites produced by Actinomadura	4
Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae	4
Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics	4
Back cover	4
Anti-mycobacterial natural products and mechanisms of action	4
Promoter engineering of natural product biosynthetic gene clusters in actinomycetes: concepts and applications	4
Contents list	3
Regulation of daptomycin biosynthesis in Streptomyces roseosporus: new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production	3
Back cover	3
Hot off the Press	3
Front cover	3
Contents list	3
Hot off the Press	3
Ring systems in natural products: structural diversity, physicochemical properties, and coverage by synthetic compounds	2
Back cover	2
The biosynthetic logic and enzymatic machinery of approved fungi-derived pharmaceuticals and agricultural biopesticides	2
Corallopyronin A: antimicrobial discovery to preclinical development	2
Harmonizing biosynthesis with post-ingestive modifications to understand the ecological functions of plant natural products	2
Contents list	2
A straightforward access to trifluoromethylated natural products through late-stage functionalization	2
Natural sesquiterpene quinone/quinols: chemistry, biological activity, and synthesis	2
Hot off the Press	2
Empowering natural product science with AI: leveraging multimodal data and knowledge graphs	2
Front cover	2
Gold-catalyzed cyclization and cycloaddition in natural product synthesis	2
Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing	2
On the evolution of coenzyme biosynthesis	2
Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	2