Biochemical Journal

Article	Citations
New tools for automated cryo-EM single-particle analysis in RELION-4.0	564
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications	163
The concept of intrinsic versus extrinsic apoptosis	105
Inhibitory feedback control of NF-κB signalling in health and disease	105
Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids	84
Understanding amphisomes	68
Nuts and bolts of the salt-inducible kinases (SIKs)	67
SREBP-1c and lipogenesis in the liver: an update	67
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	67
On the specificity of protein–protein interactions in the context of disorder	56
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity	56
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase	55
Combinations of histone post-translational modifications	54
Current data processing strategies for cryo-electron tomography and subtomogram averaging	54
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease	50
Impact of Type II LRRK2 inhibitors on signaling and mitophagy	44
Classification, structural biology, and applications of mucin domain-targeting proteases	43
SNARE proteins: zip codes in vesicle targeting?	43
Cryo-EM structure of the monomeric Rhodobacter sphaeroides RC–LH1 core complex at 2.5 Å	41
The breakthrough in protein structure prediction	41
The roles of epigenetics in cancer progression and metastasis	40
The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications	40
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase	39
Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity	38
Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis	37

Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders	37
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms	37
Interactions between insulin and exercise	36
Programmed cell death: the pathways to severe COVID-19?	35
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease	35
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites	34
Hydrogen sulfide in ageing, longevity and disease	34
PI(4,5)P2: signaling the plasma membrane	33
Paradigms of receptor kinase signaling in plants	32
Tunneling nanotubes and related structures: molecular mechanisms of formation and function	32
Blackout in the powerhouse: clinical phenotypes associated with defects in the assembly of OXPHOS complexes and the mitoribosome	32
Deep learning and generative methods in cheminformatics and chemical biology: navigating small molecule space intelligently	31
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease	31
The BRCA1/BARD1 ubiquitin ligase and its substrates	31
Glycoengineering: scratching the surface	30
Systems approaches to investigate the role of NF-κB signaling in aging	30
Manipulating the exposome to enable better ageing	30
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease	29
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965	29
Cryo-EM structure of the dimeric Rhodobacter sphaeroides RC-LH1 core complex at 2.9 Å: the structural basis for dimerisation	29
Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly	28
Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches	28
Principles and practice of determining metal–protein affinities	28
Lactate cross-talk in host–pathogen interactions	27
Insulin and cancer: a tangled web	27
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase	27
Anti-glycan antibodies: roles in human disease	26
eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA	26
Signalling dynamics in embryonic development	26
Dynamic regulation of RAS and RAS signaling	26
Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches	26
Regulation of chromatin accessibility by hypoxia and HIF	26
Beyond protein modification: the rise of non-canonical ADP-ribosylation	25
Protein tyrosine phosphatases in cell adhesion	25
FoxO transcription factors in mitochondrial homeostasis	25
Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation	25
Cryo-EM structure of the Rhodospirillum rubrum RC–LH1 complex at 2.5 Å	24
Phosphatidylserine binding directly regulates TIM-3 function	24
Macropinocytosis: mechanisms and regulation	24
CLN5 and CLN3 function as a complex to regulate endolysosome function	23
NAD+-consuming enzymes in immune defense against viral infection	23
Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis	23
Regulation of the release of damage-associated molecular patterns from necroptotic cells	23
Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier	22
A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes	22
Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling	22
A global view of the human post-translational modification landscape	22
Cancer cachexia: molecular mechanism and pharmacological management	22
Oxidative signalling in seed germination and early seedling growth: an emerging role for ROS trafficking and inter-organelle communication	22
Clathrin: the molecular shape shifter	22

Pyrophosphate as an alternative energy currency in plants	22
Molecular mechanisms of mammalian autophagy	21
Cell death in skin function, inflammation, and disease	21
Phasing the intranuclear organization of steroid hormone receptors	20
PHLPPing the balance: restoration of protein kinase C in cancer	20
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway	20
Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice	19
GLUT4 On the move	19
Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs	19
Whole-body metabolic fate of branched-chain amino acids	19
The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands	18
Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy	18
Tick–human interactions: from allergic klendusity to the α-Gal syndrome	18
Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter	18
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death	18
The complex interplay between autophagy and cell death pathways	18
Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response	17
Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY)	17
The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN	17
Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1	17
Integrin αVβ1 regulates procollagen I production through a non-canonical transforming growth factor β signaling pathway in human hepatic stellate cells	16
The many ways that nature has exploited the unusual structural and chemical properties of phosphohistidine for use in proteins	16
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing	16
A pipeline to evaluate inhibitors of the Pseudomonas aeruginosa exotoxin U	16
Structure of plant photosystem I-plastocyanin complex reveals strong hydrophobic interactions	16
Protein targeting by the itaconate family in immunity and inflammation	16
Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases	16
Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia	16
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity	15
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin	15
RIP1 post-translational modifications	15
TOR complex 2 is a master regulator of plasma membrane homeostasis	15
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies	15
The role of mitochondria in cocaine addiction	15
BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression	15
Ferroptosis in plants: regulation of lipid peroxidation and redox status	15
A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding	15
Down-regulated microRNA-199a-3p enhances osteogenic differentiation of bone marrow mesenchymal stem cells by targeting Kdm3a in ovariectomized rats	14
Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants	14
IKKα plays a major role in canonical NF-κB signalling in colorectal cells	14
Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner	14
Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase	14
Meiosis initiation: a story of two sexes in all creatures great and small	14
PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus	14
Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival	13
Phosphoinositide 3-kinases in platelets, thrombosis and therapeutics	13
Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate	13
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors	13
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors	13
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state	13
Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6	13
Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis	13
Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity	13
NDP-rhamnose biosynthesis and rhamnosyltransferases: building diverse glycoconjugates in nature	13
Structure, metabolism and biological functions of steryl glycosides in mammals	13
Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae	13
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate	13
Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome	13
Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer	12
Mitochondrial genome stability in human: understanding the role of DNA repair pathways	12
GlmS mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum	12
Distinct interactors define the p63 transcriptional signature in epithelial development or cancer	12
Site IQ in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions	12
The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii	12
The biophysical basis of receptor tyrosine kinase ligand functional selectivity: Trk-B case study	12
Excitation energy transfer kinetics of trimeric, monomeric and subunit-depleted Photosystem I from Synechocystis PCC 6803	12
Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent	12
Structural basis of the human Scribble–Vangl2 association in health and disease	12
Structural basis of a chemokine heterodimer binding to glycosaminoglycans	12
Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells	12
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy	12
Capturing the domain crosstalk in full length LRRK2 and LRRK2RCKW	11
Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds	11
Importance of tyrosine phosphorylation for transmembrane signaling in plants	11
Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo	11
Resveratrol promotes lysosomal function via ER calcium-dependent TFEB activation to ameliorate lipid accumulation	11
Insight into the function of active site residues in the catalytic mechanism of human ferrochelatase	11
Mechanistic diversity in MHC class I antigen recognition	11
A conserved, buried cysteine near the P-site is accessible to cysteine modifications and increases ROS stability in the P-type plasma membrane H+-ATPase	11
A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner	11

Seasonal cold induces divergent structural/biochemical adaptations in different skeletal muscles of Columba livia: evidence for nonshivering thermogenesis in adult birds	11
PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target	11
The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors	10
Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η	10
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs	10
Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation	10
Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling	10
Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps	10
How many kinases are druggable? A review of our current understanding	10
Cryo-EM structures of the Synechocystis sp. PCC 6803 cytochrome b6f complex with and without the regulatory PetP subunit	10
Electron transfer via cytochrome b6f complex displays sensitivity to antimycin A upon STT7 kinase activation	10
Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?	10
Intelligent host engineering for metabolic flux optimisation in biotechnology	10
Temporal modulation of the NF-κB RelA network in response to different types of DNA damage	10
Understanding interleukin 11 as a disease gene and therapeutic target	10
Mechanisms of TNF-independent RIPK3-mediated cell death	10
C-type cytochrome-initiated reduction of bacterial lytic polysaccharide monooxygenases	10
Deubiquitinases in cell death and inflammation	10
Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI	10