Biochemical Journal

Article	Citations
New tools for automated cryo-EM single-particle analysis in RELION-4.0	395
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications	127
Inhibitory feedback control of NF-κB signalling in health and disease	83
The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system	81
The concept of intrinsic versus extrinsic apoptosis	75
Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids	72
Molecular mechanism of Fast Endophilin-Mediated Endocytosis	69
Understanding amphisomes	57
Nuts and bolts of the salt-inducible kinases (SIKs)	56
SREBP-1c and lipogenesis in the liver: an update	51
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease	49
PGR5 is required for efficient Q cycle in the cytochrome b6f complex during cyclic electron flow	48
O-glycan recognition and function in mice and human cancers	47
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity	46
Combinations of histone post-translational modifications	46
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase	45
Current data processing strategies for cryo-electron tomography and subtomogram averaging	43
On the specificity of protein–protein interactions in the context of disorder	42
Inorganic polyphosphate is produced and hydrolyzed in F0F1-ATP synthase of mammalian mitochondria	42
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	41
Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis	40
An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels	39
The breakthrough in protein structure prediction	39
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase	38
Classification, structural biology, and applications of mucin domain-targeting proteases	37

Impact of Type II LRRK2 inhibitors on signaling and mitophagy	37
Rationally designed peptide-based inhibitor of Aβ42 fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease	36
SNARE proteins: zip codes in vesicle targeting?	36
Cryo-EM structure of the monomeric Rhodobacter sphaeroides RC–LH1 core complex at 2.5 Å	34
Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery	33
The ever-expanding limits of enzyme catalysis and biodegradation: polyaromatic, polychlorinated, polyfluorinated, and polymeric compounds	32
Cell Atlas technologies and insights into tissue architecture	32
Phosphoinositide lipids in primary cilia biology	32
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites	31
Interactions between insulin and exercise	31
SLC6A14, a Na+/Cl−-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling	31
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease	31
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease	31
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms	31
Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity	30
Programmed cell death: the pathways to severe COVID-19?	30
Source of 12C in Calvin–Benson cycle intermediates and isoprene emitted from plant leaves fed with 13CO2	29
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease	29
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965	28
Blackout in the powerhouse: clinical phenotypes associated with defects in the assembly of OXPHOS complexes and the mitoribosome	28
Structure-based enzyme engineering improves donor-substrate recognition of Arabidopsis thaliana glycosyltransferases	28
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders	28
Deep learning and generative methods in cheminformatics and chemical biology: navigating small molecule space intelligently	28
The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications	28
Gut microbiome a promising target for management of respiratory diseases	27
The BRCA1/BARD1 ubiquitin ligase and its substrates	27
Cryo-EM structure of the dimeric Rhodobacter sphaeroides RC-LH1 core complex at 2.9 Å: the structural basis for dimerisation	27
SUMO E3 ligase CBX4 regulates hTERT-mediated transcription of CDH1 and promotes breast cancer cell migration and invasion	26
Glycoengineering: scratching the surface	26
Manipulating the exposome to enable better ageing	26
Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle	26
The roles of epigenetics in cancer progression and metastasis	26
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase	26
The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice	25
Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis	25
Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches	25
Genetic activity during early plant embryogenesis	25
The transport mechanism of P4 ATPase lipid flippases	24
Hydrogen sulfide in ageing, longevity and disease	24
Linking transcription, RNA polymerase II elongation and alternative splicing	24
Principles and practice of determining metal–protein affinities	24
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72	24
eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA	24
PI(4,5)P2: signaling the plasma membrane	24
The composition and turnover of the Arabidopsis thaliana 80S cytosolic ribosome	24
Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s	23
Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics	23
Cryo-EM structure of the Rhodospirillum rubrum RC–LH1 complex at 2.5 Å	23
Lactate cross-talk in host–pathogen interactions	23
Impact of pesticide exposure on adipose tissue development and function	22

Mitochondrial control of cellular protein homeostasis	22
Systems approaches to investigate the role of NF-κB signaling in aging	22
DNA-damage tolerance through PCNA ubiquitination and sumoylation	22
Heat shock protein 90 inhibitors suppress pyroptosis in THP-1 cells	22
Functional characterization of human brown adipose tissue metabolism	22
Tunneling nanotubes and related structures: molecular mechanisms of formation and function	22
Anti-glycan antibodies: roles in human disease	22
Insulin and cancer: a tangled web	22
GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression	22
Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches	21
Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly	21
NAD+-consuming enzymes in immune defense against viral infection	21
Protein tyrosine phosphatases in cell adhesion	21
Oxidative signalling in seed germination and early seedling growth: an emerging role for ROS trafficking and inter-organelle communication	21
Regulatory thiol oxidation in chloroplast metabolism, oxidative stress response and environmental signaling in plants	21
Phosphatidylserine binding directly regulates TIM-3 function	20
Phasing the intranuclear organization of steroid hormone receptors	20
Pyrophosphate as an alternative energy currency in plants	20
Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier	20
Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis	19
PHLPPing the balance: restoration of protein kinase C in cancer	19
Regulation of chromatin accessibility by hypoxia and HIF	19
CLN5 and CLN3 function as a complex to regulate endolysosome function	19
Heart failure and the glutathione cycle: an integrated view	19
Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in mice	19
Beyond protein modification: the rise of non-canonical ADP-ribosylation	19
Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling	18
Exploiting S-nitrosylation for cancer therapy: facts and perspectives	18
Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy	17
DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway	17
Dynamic regulation of RAS and RAS signaling	17
Regulation of the release of damage-associated molecular patterns from necroptotic cells	17
Cancer cachexia: molecular mechanism and pharmacological management	17
Signalling dynamics in embryonic development	17
Leucine and branched-chain amino acid metabolism contribute to the growth of bone sarcomas by regulating AMPK and mTORC1 signaling	17
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death	17
Reading the phosphorylation code: binding of the 14-3-3 protein to multivalent client phosphoproteins	17
Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice	17
Lysosomal sulfatases: a growing family	17
FoxO transcription factors in mitochondrial homeostasis	17
Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation	17
Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs	16
The complex interplay between autophagy and cell death pathways	16
Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity	16
Dopamine is an aryl hydrocarbon receptor agonist	16
Tick–human interactions: from allergic klendusity to the α-Gal syndrome	16
Thermogenic adipocytes: lineage, function and therapeutic potential	16
Molecular mechanisms of mammalian autophagy	16
GLUT4 On the move	16
Clathrin: the molecular shape shifter	16
Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate	16
Crystal structure of an insect antifreeze protein reveals ordered waters on the ice-binding surface	15
Mechanistic and structural insights into histone H2A–H2B chaperone in chromatin regulation	15
Unconventional biochemical regulation of the oxidative pentose phosphate pathway in the model cyanobacterium Synechocystis sp. PCC 6803	15
Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY)	15
Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1	15
Cell death in skin function, inflammation, and disease	15
Structure of plant photosystem I-plastocyanin complex reveals strong hydrophobic interactions	15
Paradigms of receptor kinase signaling in plants	15
Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation	15
The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN	15
Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter	15
The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands	15
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway	15
A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes	15
Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like CDPK1, a multistage growth regulator of P. falciparum	14
Identifying key residues and key interactions for the binding of LEAP2 to receptor GHSR1a	14
Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation	14
The role of mitochondria in cocaine addiction	14
The origin, evolution and diversification of multiple isoforms of light-dependent protochlorophyllide oxidoreductase (LPOR): focus on angiosperms	14
RIP1 post-translational modifications	14
Xanthophyll carotenoids stabilise the association of cyanobacterial chlorophyll synthase with the LHC-like protein HliD	14
A pipeline to evaluate inhibitors of the Pseudomonas aeruginosa exotoxin U	13
Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift	13
TOR complex 2 is a master regulator of plasma membrane homeostasis	13
Whole-body metabolic fate of branched-chain amino acids	13
Integrin αVβ1 regulates procollagen I production through a non-canonical transforming growth factor β signaling pathway in human hepatic stellate cells	13
Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia	13
Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase	13
Selective inhibition of Rhizopus eumelanin biosynthesis by novel natural product scaffold-based designs caused significant inhibition of fungal pathogenesis	13

Carrot ‘antifreeze’ protein has an irregular ice-binding site that confers weak freezing point depression but strong inhibition of ice recrystallization	13
The autocrine role of FGF21 in cultured adipocytes	13
Three cytosolic NAD-malate dehydrogenase isoforms of Arabidopsis thaliana: on the crossroad between energy fluxes and redox signaling	13
Rubisco lysine acetylation occurs at very low stoichiometry in mature Arabidopsis leaves: implications for regulation of enzyme function	13
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors	13
Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response	13
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies	12
Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6	12
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity	12
Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells	12
RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics	12
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies	12
An allosteric hot spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling	12
Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1H-NMR-based metabolomic study in pancreatic cancer cells	12
Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine	12
Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae	12
Structural basis of a chemokine heterodimer binding to glycosaminoglycans	12
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin	12
Functional role of TRPC6 and STIM2 in cytosolic and endoplasmic reticulum Ca2+ content in resting estrogen receptor-positive breast cancer cells	12
NDP-rhamnose biosynthesis and rhamnosyltransferases: building diverse glycoconjugates in nature	12
Biochemical and functional characterization of a mitochondrial citrate carrier in Arabidopsis thaliana	12
Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner	12
Macropinocytosis: mechanisms and regulation	12
Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent	12
Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases	12
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state	12
Resveratrol promotes lysosomal function via ER calcium-dependent TFEB activation to ameliorate lipid accumulation	11
Phosphoinositide 3-kinases in platelets, thrombosis and therapeutics	11
Thioproline formation as a driver of formaldehyde toxicity in Escherichia coli	11
Down-regulated microRNA-199a-3p enhances osteogenic differentiation of bone marrow mesenchymal stem cells by targeting Kdm3a in ovariectomized rats	11
The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii	11
Synergistic role of nucleotides and lipids for the self-assembly of Shs1 septin oligomers	11
BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression	11
Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome	11
Molecular dynamics simulations and biochemical characterization of Pf14-3-3 and PfCDPK1 interaction towards its role in growth of human malaria parasite	11
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy	11
Meiosis initiation: a story of two sexes in all creatures great and small	11
Pro4 prolyl peptide bond isomerization in human galectin-7 modulates the monomer-dimer equilibrum to affect function	11
Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate	11
Importance of tyrosine phosphorylation for transmembrane signaling in plants	11
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate	11
The biophysical basis of receptor tyrosine kinase ligand functional selectivity: Trk-B case study	11
Molecular mechanisms of eukaryotic origin initiation, replication fork progression, and chromatin maintenance	11
Trypanosoma cruzi synthesizes proline via a Δ1-pyrroline-5-carboxylate reductase whose activity is fine-tuned by NADPH cytosolic pools	11
Structure-based design of small bicyclic peptide inhibitors of Cripto-1 activity	11
Structure, metabolism and biological functions of steryl glycosides in mammals	11
The many ways that nature has exploited the unusual structural and chemical properties of phosphohistidine for use in proteins	11
Structural basis of the human Scribble–Vangl2 association in health and disease	11
Structural–functional diversity of malaria parasite's PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding	11
AMP-activated protein kinase regulates alternative pre-mRNA splicing by phosphorylation of SRSF1	11
Excitation energy transfer kinetics of trimeric, monomeric and subunit-depleted Photosystem I from Synechocystis PCC 6803	11