OOIR: Observatory of International Research

Papers

(The TQCC of Biochemical Journal is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Michael D. Waterfield	130
Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast	86
Development of an OTUD1 ubiquitin variant inhibitor	85
Cas11 augments Cascade functions in type I-E CRISPR system but is redundant for gene silencing and plasmid interference	82
Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and β-elimination activities across diverse substrates	79
Combinatorial approaches for mitigating resistance to KRAS-targeted therapies	75
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane	65
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells	59
Rules of the road: how to turn off kinesin motors	56
Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif	53
A curated list of targeted optimized promiscuous ketoreductases (TOP-K)	50
A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity	39
Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor	39
In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity	38
Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method	37
A guide to ERK dynamics, part 2: downstream decoding	36
Cold exposure remodels bile acid metabolism in a mouse strain- and tissue-specific manner	36
Respiratory epithelial cell types, states and fates in the era of single-cell RNA-sequencing	35
Modulating backbone flexibility in hydroxamate siderophores for improved iron chelation and peptide nucleic acid delivery into bacteria	33
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome	32
The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination	32
Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice	32
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses	30
TOR complex 2 is a master regulator of plasma membrane homeostasis	28
The atypical thioredoxin ‘Alr2205’, a newly identified partner of the typical 2-Cys-Peroxiredoxin, safeguards the cyanobacterium Anabaena from oxidative stress	26

BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia	26
Calcium signalling components underlying NPK homeostasis: potential avenues for exploration	26
CORM-3 induces DNA damage through Ru(II) binding to DNA	25
Characterisation of an influenza B virus-derived peptide presented by HLA-B*18:01	25
Identification and functional characterization of two CXCL17 paralogs from zebrafish	25
The role of linker length and composition in actin binding and bundling by palladin	25
Improved furfural tolerance in Escherichia coli mediated by heterologous NADH-dependent benzyl alcohol dehydrogenases	25
Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex	24
Towards ‘end-to-end’ analysis and understanding of biological timecourse data	24
De novo talin-1 variant L353F connects multifaceted clinical symptoms to alterations in talin-1 function	24
Identification and characterization of the Doublesex gene and its mRNA isoforms in the brine shrimp Artemia franciscana	23
Sequence variation in the active site of mobile colistin resistance proteins is evolutionarily accommodated through inter-domain interactions	23
Clostridium beijerinckii displays a soluble [FeFe]-hydrogenase/formate dehydrogenase enzyme complex that links H2 and CO2 metabolism	23
RhoGAP6 interacts with COPI to regulate protein transport	23
The role of mitochondrial RNA association for mitochondrial homeostasis in neurons	22
Correction: Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity.	21
Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues	21
Lead induces the upregulation of protein arginine methyltransferase 5 possibly by its promoter demethylation	21
Expression of Concern: Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway	21
Protein kinase A and local signaling in cancer	20
Structural characterization of OsPDIL2-3, a rice protein disulfide isomerase involved in prolamin accumulation	20
Cryo-EM structure of human MG53 homodimer	20
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator	19
Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?	19
Interplay of constipation, intestinal barrier dysfunction and fungal exposome in aetiopathogenesis of Parkinson’s disease: hypothesis with supportive data	19
Oligomeric assemblies of plant biotin carboxylase revealed by cryo-EM and cross-linking	19
Correction: The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h	18
The uncharacterized protein ZNF200 interacts with PRMT3 and aids its stability and nuclear translocation	18
Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling	18
Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway	18
NAD-catabolizing ectoenzymes of Schistosoma mansoni	18
Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway	17
Gibberellin-biosynthetic ent-kaurene synthases in higher plants do not require their non-catalytic domains for the catalysis	17
Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1	17
Structure and function of MDM2 and MDM4 in health and disease	16
Functional analysis and transcriptional profiling of non-coding RNAs in yeast	16
Use of hydrogen deuterium exchange mass spectrometry in tandem with modern structural biology	16
Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C)	16
Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis	16
Thermodynamic analysis of Zα domain-nucleic acid interactions	16
An expanded role for single-cell chemical genomics profiling in drug discovery	15
Adapting to change: resolving the dynamic and dual roles of NCK1 and NCK2	15
Retraction: Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure	15
Targeting bacterial degradation machinery as an antibacterial strategy	15
Yop1 stability and membrane curvature generation propensity are controlled by its oligomerisation interface	15
Retraction: Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin	15
Elevated CO2 alters photosynthesis, growth and susceptibility to powdery mildew of oak seedlings	15
Proteostasis of immune checkpoint receptors	15
Ubiquitin E3 ligases in the plant Arg/N-degron pathway	15
EZH2 promotes chemoresistance in colorectal cancer by inhibiting autophagy through NRP1 suppression	14

Editorial Note: Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling	14
Combination amino acids and glucose effects on insulin and GLP-1 secretion	14
Comparison of Classical P81 and SVI-P Cation-Exchange Papers in Radiometric Protein Kinase Assays	14
Exopolysaccharide is detrimental for the symbiotic performance of Sinorhizobium fredii HH103 mutants with a truncated lipopolysaccharide core	14
Leukotriene B4 receptor 1 does not mediate disease progression in a mouse model of liver fibrosis	14
Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter	14
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth	13
Abscisic acid triggers vitamin E accumulation by transient transcript activation of VTE5 and VTE6 in sweet cherry fruits	13
The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors	13
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity	13
Distinct interactors define the p63 transcriptional signature in epithelial development or cancer	13
Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2	13
Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes	13
Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery	13
Peeking behind the carbocation: identification of (alternative) catalytic bases in the class II active site of conifer resin acid diterpene synthases	13
Activity-based probes for dynamic characterisation of polysaccharide-degrading enzymes	13
The peculiar properties of mitochondrial carriers of the SLC25 family	12
A metabolite extracted from E. coli suppresses tau aggregation	12
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlierAtITPK4	12
Towards broad-spectrum antiviral drugs: inhibition of transmembrane serine proteases	12
Docking in the Abies grandis abietaenol synthase to investigate the mechanism underlying conifer resin acid diterpene synthase evolution	12
DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability	11
Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5	11
Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity	11
The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms	11
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	11
Sequence rules for a long SPOP-binding degron required for protein ubiquitylation	11
Proteomic mapping and optogenetic manipulation of membrane contact sites	11
Macropinocytosis: mechanisms and regulation	11
Penetrant PKCβ mutation in ATLL displays a mixed gain-of-function	11
Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity	10
Dynamic interchange of local residue–residue interactions in the largely extended single alpha-helix in Drebrin	10
The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase	10
The impact of cell states on heterochromatin dynamics	10
Genetic modulation of CWD prion propagation in cervid PrP Drosophila	10
PHF1 compartmentalizes PRC2 via phase separation	10
A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy	10
The role of the γ subunit in the photosystem of the lowest-energy phototrophs	10
Expression and characterization of an endo-β-1,6-galactanase from Arabidopsis thaliana	10
Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain	10
Synthesis, biochemical characterization and in silico investigation of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid derivatives: dual action mode inhibitors of urease and virulent bacterial	10
The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii	10
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation	9
The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes	9
Molecular foundations of collagen triple helical assembly: the central role of prolyl-4-hydroxylation	9
Common and unique features of glycosylation and glycosyltransferases in African trypanosomes	9
Modulation of Ube2R1 activity by a nanobody that binds near its N-terminus	9
The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?	9
Phosphorus-specific, liquid chromatography inductively coupled plasma mass spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism	9
Genome damage accumulated in seed ageing leads to plant genome instability and growth inhibition	9
Inducing TRIB2-targeted protein degradation to reverse chemoresistance in acute myeloid leukaemia	9
The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death	9
Structural basis for inhibition of SpyCas9 by the anti-CRISPR protein AcrIIA26	9
Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2	9
AmyloGram reveals amyloidogenic potential in stroke thrombus proteomes	9
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing	9
Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8	9
The bacterial transcription terminator, Rho, functions as an RNA:DNA hybrid (RDH) helicase in vivo	9
The monodomain Kunitz protein EgKU-7 from the dog tapeworm Echinococcus granulosus is a high-affinity trypsin inhibitor with two interaction sites	9
Modulation of Nur77–DNA interactions by the glucocorticoid receptor	9
Plant adaptation to climate change	9