Biochemical Journal

Article	Citations
New tools for automated cryo-EM single-particle analysis in RELION-4.0	377
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications	123
Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics	109
Processing of the SARS-CoV pp1a/ab nsp7–10 region	88
Inhibitory feedback control of NF-κB signalling in health and disease	79
The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system	79
The concept of intrinsic versus extrinsic apoptosis	72
Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids	68
Molecular mechanism of Fast Endophilin-Mediated Endocytosis	66
The NLRP3 inflammasome regulates adipose tissue metabolism	56
Understanding amphisomes	55
Nuts and bolts of the salt-inducible kinases (SIKs)	53
SREBP-1c and lipogenesis in the liver: an update	50
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease	49
PGR5 is required for efficient Q cycle in the cytochrome b6f complex during cyclic electron flow	47
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity	46
O-glycan recognition and function in mice and human cancers	45
Combinations of histone post-translational modifications	44
Current data processing strategies for cryo-electron tomography and subtomogram averaging	42
On the specificity of protein–protein interactions in the context of disorder	41
Inorganic polyphosphate is produced and hydrolyzed in F0F1-ATP synthase of mammalian mitochondria	41
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase	41
An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels	39
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	39
Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis	39

CBL–CIPK module-mediated phosphoregulation: facts and hypothesis	37
The breakthrough in protein structure prediction	37
Impact of Type II LRRK2 inhibitors on signaling and mitophagy	37
Rationally designed peptide-based inhibitor of Aβ42 fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease	36
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase	36
Classification, structural biology, and applications of mucin domain-targeting proteases	36
SNARE proteins: zip codes in vesicle targeting?	34
Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery	33
Phosphoinositide lipids in primary cilia biology	32
Cryo-EM structure of the monomeric Rhodobacter sphaeroides RC–LH1 core complex at 2.5 Å	32
Cell Atlas technologies and insights into tissue architecture	32
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms	31
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease	31
The ever-expanding limits of enzyme catalysis and biodegradation: polyaromatic, polychlorinated, polyfluorinated, and polymeric compounds	31
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites	31
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease	31
SLC6A14, a Na+/Cl−-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling	30
Interactions between insulin and exercise	30
Programmed cell death: the pathways to severe COVID-19?	29
Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity	29
Source of 12C in Calvin–Benson cycle intermediates and isoprene emitted from plant leaves fed with 13CO2	28
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders	28
Structure-based enzyme engineering improves donor-substrate recognition of Arabidopsis thaliana glycosyltransferases	28
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease	27
Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease	27
The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications	27
Blackout in the powerhouse: clinical phenotypes associated with defects in the assembly of OXPHOS complexes and the mitoribosome	27
SUMO E3 ligase CBX4 regulates hTERT-mediated transcription of CDH1 and promotes breast cancer cell migration and invasion	26
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965	26
Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle	26
Manipulating the exposome to enable better ageing	26
The BRCA1/BARD1 ubiquitin ligase and its substrates	26
The roles of epigenetics in cancer progression and metastasis	26
Deep learning and generative methods in cheminformatics and chemical biology: navigating small molecule space intelligently	26
Cryo-EM structure of the dimeric Rhodobacter sphaeroides RC-LH1 core complex at 2.9 Å: the structural basis for dimerisation	25
Glycoengineering: scratching the surface	25
Gut microbiome a promising target for management of respiratory diseases	25
Genetic activity during early plant embryogenesis	25
The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice	24
Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis	24
Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches	24
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72	24
eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA	24
PI(4,5)P2: signaling the plasma membrane	24
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase	24
Mechanism of sphingosine 1-phosphate clearance from blood	23
Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s	23
Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics	23
Hydrogen sulfide in ageing, longevity and disease	23
Linking transcription, RNA polymerase II elongation and alternative splicing	23

The transport mechanism of P4 ATPase lipid flippases	23
The composition and turnover of the Arabidopsis thaliana 80S cytosolic ribosome	23
Impact of pesticide exposure on adipose tissue development and function	22
Mitochondrial control of cellular protein homeostasis	22
GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression	22
Principles and practice of determining metal–protein affinities	22
Functional characterization of human brown adipose tissue metabolism	22
Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2	22
Cryo-EM structure of the Rhodospirillum rubrum RC–LH1 complex at 2.5 Å	22
Anti-glycan antibodies: roles in human disease	22
DNA-damage tolerance through PCNA ubiquitination and sumoylation	22
Systems approaches to investigate the role of NF-κB signaling in aging	21
Oxidative signalling in seed germination and early seedling growth: an emerging role for ROS trafficking and inter-organelle communication	21
Lactate cross-talk in host–pathogen interactions	21
Insulin and cancer: a tangled web	21
Heat shock protein 90 inhibitors suppress pyroptosis in THP-1 cells	21
Protein tyrosine phosphatases in cell adhesion	21
NAD+-consuming enzymes in immune defense against viral infection	20
Tunneling nanotubes and related structures: molecular mechanisms of formation and function	20
Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches	20
Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier	20
Regulatory thiol oxidation in chloroplast metabolism, oxidative stress response and environmental signaling in plants	20
Phasing the intranuclear organization of steroid hormone receptors	20
Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly	20
Phosphatidylserine binding directly regulates TIM-3 function	19
Heart failure and the glutathione cycle: an integrated view	19
Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in mice	19
CLN5 and CLN3 function as a complex to regulate endolysosome function	19
PHLPPing the balance: restoration of protein kinase C in cancer	19
Comprehensive analysis of the dermatophyte Trichophyton rubrum transcriptional profile reveals dynamic metabolic modulation	18
Exploiting S-nitrosylation for cancer therapy: facts and perspectives	18
Pyrophosphate as an alternative energy currency in plants	18
Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling	18
Regulation of chromatin accessibility by hypoxia and HIF	18
Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis	18
Beyond protein modification: the rise of non-canonical ADP-ribosylation	18
Genetic evidences for the core biosynthesis pathway, regulation, transport and secretion of liamocins in yeast-like fungal cells	17
Lysosomal sulfatases: a growing family	17
Cancer cachexia: molecular mechanism and pharmacological management	17
Signalling dynamics in embryonic development	16
DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway	16
FoxO transcription factors in mitochondrial homeostasis	16
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death	16
Clathrin: the molecular shape shifter	16
Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy	16
Biochemical adaptations in white adipose tissue following aerobic exercise: from mitochondrial biogenesis to browning	16
Dynamic regulation of RAS and RAS signaling	16
Reading the phosphorylation code: binding of the 14-3-3 protein to multivalent client phosphoproteins	16
Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity	16
Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs	16
Leucine and branched-chain amino acid metabolism contribute to the growth of bone sarcomas by regulating AMPK and mTORC1 signaling	16
GLUT4 On the move	16
Regulation of the release of damage-associated molecular patterns from necroptotic cells	16
Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate	16
Thermogenic adipocytes: lineage, function and therapeutic potential	16
Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity	15
The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands	15
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway	15
Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1	15
Molecular mechanisms of mammalian autophagy	15
Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter	15
The complex interplay between autophagy and cell death pathways	15
Tick–human interactions: from allergic klendusity to the α-Gal syndrome	15
Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation	15
Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice	15
Crystal structure of an insect antifreeze protein reveals ordered waters on the ice-binding surface	15
Structure of plant photosystem I-plastocyanin complex reveals strong hydrophobic interactions	15
Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation	15
Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY)	15
The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN	15
Dopamine is an aryl hydrocarbon receptor agonist	14
Epigenetic dynamics of the thermogenic gene program of adipocytes	14
Identifying key residues and key interactions for the binding of LEAP2 to receptor GHSR1a	14
Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like CDPK1, a multistage growth regulator of P. falciparum	14
Mechanistic and structural insights into histone H2A–H2B chaperone in chromatin regulation	14
Unconventional biochemical regulation of the oxidative pentose phosphate pathway in the model cyanobacterium Synechocystis sp. PCC 6803	14
Cell death in skin function, inflammation, and disease	14
The role of mitochondria in cocaine addiction	14
Xanthophyll carotenoids stabilise the association of cyanobacterial chlorophyll synthase with the LHC-like protein HliD	14
Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response	13

A pipeline to evaluate inhibitors of the Pseudomonas aeruginosa exotoxin U	13
Three cytosolic NAD-malate dehydrogenase isoforms of Arabidopsis thaliana: on the crossroad between energy fluxes and redox signaling	13
Selective inhibition of Rhizopus eumelanin biosynthesis by novel natural product scaffold-based designs caused significant inhibition of fungal pathogenesis	13
The origin, evolution and diversification of multiple isoforms of light-dependent protochlorophyllide oxidoreductase (LPOR): focus on angiosperms	13
The autocrine role of FGF21 in cultured adipocytes	13
Integrin αVβ1 regulates procollagen I production through a non-canonical transforming growth factor β signaling pathway in human hepatic stellate cells	13
Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia	13
Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase	13
Rubisco lysine acetylation occurs at very low stoichiometry in mature Arabidopsis leaves: implications for regulation of enzyme function	13
Carrot ‘antifreeze’ protein has an irregular ice-binding site that confers weak freezing point depression but strong inhibition of ice recrystallization	13
RIP1 post-translational modifications	13
Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift	13
Paradigms of receptor kinase signaling in plants	13
A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes	13
Whole-body metabolic fate of branched-chain amino acids	12
An allosteric hot spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling	12
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors	12
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies	12
Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae	12
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity	12
Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1H-NMR-based metabolomic study in pancreatic cancer cells	12
Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases	12
Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent	12
Biochemical and functional characterization of a mitochondrial citrate carrier in Arabidopsis thaliana	12
TOR complex 2 is a master regulator of plasma membrane homeostasis	12
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state	12
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies	12
NDP-rhamnose biosynthesis and rhamnosyltransferases: building diverse glycoconjugates in nature	12
Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner	12
Structural basis of a chemokine heterodimer binding to glycosaminoglycans	12
Molecular dynamics simulations and biochemical characterization of Pf14-3-3 and PfCDPK1 interaction towards its role in growth of human malaria parasite	11
Meiosis initiation: a story of two sexes in all creatures great and small	11
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy	11
Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6	11
Importance of tyrosine phosphorylation for transmembrane signaling in plants	11
AMP-activated protein kinase regulates alternative pre-mRNA splicing by phosphorylation of SRSF1	11
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin	11
RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics	11
Structure, metabolism and biological functions of steryl glycosides in mammals	11
Down-regulated microRNA-199a-3p enhances osteogenic differentiation of bone marrow mesenchymal stem cells by targeting Kdm3a in ovariectomized rats	11
The many ways that nature has exploited the unusual structural and chemical properties of phosphohistidine for use in proteins	11
Macropinocytosis: mechanisms and regulation	11
The biophysical basis of receptor tyrosine kinase ligand functional selectivity: Trk-B case study	11
Excitation energy transfer kinetics of trimeric, monomeric and subunit-depleted Photosystem I from Synechocystis PCC 6803	11
Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation	11
Structure-based design of small bicyclic peptide inhibitors of Cripto-1 activity	11
Pro4 prolyl peptide bond isomerization in human galectin-7 modulates the monomer-dimer equilibrum to affect function	11
Structural basis of the human Scribble–Vangl2 association in health and disease	11
The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii	11
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate	11
BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression	11
Molecular mechanisms of eukaryotic origin initiation, replication fork progression, and chromatin maintenance	11
Promutagenic bypass of 7,8-dihydro-8-oxoadenine by translesion synthesis DNA polymerase Dpo4	10
Sunitinib inhibits RNase L by destabilizing its active dimer conformation	10
Mitochondrial genome stability in human: understanding the role of DNA repair pathways	10
Trypanosoma cruzi synthesizes proline via a Δ1-pyrroline-5-carboxylate reductase whose activity is fine-tuned by NADPH cytosolic pools	10
Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival	10
Thioproline formation as a driver of formaldehyde toxicity in Escherichia coli	10
A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding	10
Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η	10
The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions	10
Structural–functional diversity of malaria parasite's PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding	10
Synergistic role of nucleotides and lipids for the self-assembly of Shs1 septin oligomers	10
Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome	10
Resveratrol promotes lysosomal function via ER calcium-dependent TFEB activation to ameliorate lipid accumulation	10
ACE-domain selectivity extends beyond direct interacting residues at the active site	10
Phosphoinositide 3-kinases in platelets, thrombosis and therapeutics	10
Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine	10
Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate	10
The molecular functions of RIT1 and its contribution to human disease	10
Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495	10
Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells	10
Temporal modulation of the NF-κB RelA network in response to different types of DNA damage	10
Functional role of TRPC6 and STIM2 in cytosolic and endoplasmic reticulum Ca2+ content in resting estrogen receptor-positive breast cancer cells	10
Hurdles to uptake of mesenchymal stem cells and their progenitors in therapeutic products	10
Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds	10
Merkel cell polyomavirus small tumour antigen activates the p38 MAPK pathway to enhance cellular motility	10
PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus	9
Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer	9
Mechanistic diversity in MHC class I antigen recognition	9
Diversity of ACE2 and its interaction with SARS-CoV-2 receptor binding domain	9
Ferroptosis in plants: regulation of lipid peroxidation and redox status	9
The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?	9
Novel molecular aspects of the CRISPR backbone protein ‘Cas7’ from cyanobacteria	9
NRF2/ACSS2 axis mediates the metabolic effect of alcohol drinking on esophageal squamous cell carcinoma	9
Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants	9
Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps	9
Structures of an engineered phospholipase D with specificity for secondary alcohol transphosphatidylation: insights into plasticity of substrate binding and activation	9
Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotein sialylation in mice	9
Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation	9
Ubiquitination-activating enzymes UBE1 and UBA6 regulate ubiquitination and expression of cardiac sodium channel Nav1.5	9
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors	9
Identification and characterization of adipose surface epitopes	9
PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target	9
A small molecule inhibitor of HER3: a proof-of-concept study	9