Biochemical Journal

Article	Citations
New tools for automated cryo-EM single-particle analysis in RELION-4.0	564
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications	163
Inhibitory feedback control of NF-κB signalling in health and disease	105
The concept of intrinsic versus extrinsic apoptosis	105
Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids	84
Understanding amphisomes	68
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	67
Nuts and bolts of the salt-inducible kinases (SIKs)	67
SREBP-1c and lipogenesis in the liver: an update	67
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity	56
On the specificity of protein–protein interactions in the context of disorder	56
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase	55
Current data processing strategies for cryo-electron tomography and subtomogram averaging	54
Combinations of histone post-translational modifications	54
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease	50
Impact of Type II LRRK2 inhibitors on signaling and mitophagy	44
SNARE proteins: zip codes in vesicle targeting?	43
Classification, structural biology, and applications of mucin domain-targeting proteases	43
The breakthrough in protein structure prediction	41
Cryo-EM structure of the monomeric Rhodobacter sphaeroides RC–LH1 core complex at 2.5 Å	41
The roles of epigenetics in cancer progression and metastasis	40
The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications	40
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase	39
Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity	38
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders	37

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms	37
Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis	37
Interactions between insulin and exercise	36
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease	35
Programmed cell death: the pathways to severe COVID-19?	35
Hydrogen sulfide in ageing, longevity and disease	34
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites	34
PI(4,5)P2: signaling the plasma membrane	33
Blackout in the powerhouse: clinical phenotypes associated with defects in the assembly of OXPHOS complexes and the mitoribosome	32
Paradigms of receptor kinase signaling in plants	32
Tunneling nanotubes and related structures: molecular mechanisms of formation and function	32
The BRCA1/BARD1 ubiquitin ligase and its substrates	31
Deep learning and generative methods in cheminformatics and chemical biology: navigating small molecule space intelligently	31
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease	31
Manipulating the exposome to enable better ageing	30
Glycoengineering: scratching the surface	30
Systems approaches to investigate the role of NF-κB signaling in aging	30
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965	29
Cryo-EM structure of the dimeric Rhodobacter sphaeroides RC-LH1 core complex at 2.9 Å: the structural basis for dimerisation	29
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease	29
Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches	28
Principles and practice of determining metal–protein affinities	28
Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly	28
Insulin and cancer: a tangled web	27
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase	27
Lactate cross-talk in host–pathogen interactions	27
Signalling dynamics in embryonic development	26
Dynamic regulation of RAS and RAS signaling	26
Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches	26
Regulation of chromatin accessibility by hypoxia and HIF	26
Anti-glycan antibodies: roles in human disease	26
eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA	26
FoxO transcription factors in mitochondrial homeostasis	25
Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation	25
Beyond protein modification: the rise of non-canonical ADP-ribosylation	25
Protein tyrosine phosphatases in cell adhesion	25
Phosphatidylserine binding directly regulates TIM-3 function	24
Macropinocytosis: mechanisms and regulation	24
Cryo-EM structure of the Rhodospirillum rubrum RC–LH1 complex at 2.5 Å	24
Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis	23
Regulation of the release of damage-associated molecular patterns from necroptotic cells	23
CLN5 and CLN3 function as a complex to regulate endolysosome function	23
NAD+-consuming enzymes in immune defense against viral infection	23
Oxidative signalling in seed germination and early seedling growth: an emerging role for ROS trafficking and inter-organelle communication	22
Clathrin: the molecular shape shifter	22
Pyrophosphate as an alternative energy currency in plants	22
Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier	22
A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes	22
Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling	22
A global view of the human post-translational modification landscape	22

Cancer cachexia: molecular mechanism and pharmacological management	22
Cell death in skin function, inflammation, and disease	21
Molecular mechanisms of mammalian autophagy	21
PHLPPing the balance: restoration of protein kinase C in cancer	20
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway	20
Phasing the intranuclear organization of steroid hormone receptors	20
GLUT4 On the move	19
Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs	19
Whole-body metabolic fate of branched-chain amino acids	19
Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice	19
Tick–human interactions: from allergic klendusity to the α-Gal syndrome	18
Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter	18
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death	18
The complex interplay between autophagy and cell death pathways	18
The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands	18
Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy	18
Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY)	17
The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN	17
Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1	17
Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response	17
Structure of plant photosystem I-plastocyanin complex reveals strong hydrophobic interactions	16
Protein targeting by the itaconate family in immunity and inflammation	16
Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases	16
Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia	16
Integrin αVβ1 regulates procollagen I production through a non-canonical transforming growth factor β signaling pathway in human hepatic stellate cells	16
The many ways that nature has exploited the unusual structural and chemical properties of phosphohistidine for use in proteins	16
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing	16
A pipeline to evaluate inhibitors of the Pseudomonas aeruginosa exotoxin U	16
The role of mitochondria in cocaine addiction	15
BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression	15
Ferroptosis in plants: regulation of lipid peroxidation and redox status	15
A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding	15
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity	15
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin	15
RIP1 post-translational modifications	15
TOR complex 2 is a master regulator of plasma membrane homeostasis	15
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies	15
IKKα plays a major role in canonical NF-κB signalling in colorectal cells	14
Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner	14
Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase	14
Meiosis initiation: a story of two sexes in all creatures great and small	14
PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus	14
Down-regulated microRNA-199a-3p enhances osteogenic differentiation of bone marrow mesenchymal stem cells by targeting Kdm3a in ovariectomized rats	14
Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants	14
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state	13
Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6	13
Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis	13
Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity	13
NDP-rhamnose biosynthesis and rhamnosyltransferases: building diverse glycoconjugates in nature	13
Structure, metabolism and biological functions of steryl glycosides in mammals	13
Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae	13
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate	13
Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome	13
Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival	13
Phosphoinositide 3-kinases in platelets, thrombosis and therapeutics	13
Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate	13
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors	13
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors	13
Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent	12
Structural basis of the human Scribble–Vangl2 association in health and disease	12
Structural basis of a chemokine heterodimer binding to glycosaminoglycans	12
Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells	12
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy	12
Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer	12
Mitochondrial genome stability in human: understanding the role of DNA repair pathways	12
GlmS mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum	12
Distinct interactors define the p63 transcriptional signature in epithelial development or cancer	12
Site IQ in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions	12
The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii	12
The biophysical basis of receptor tyrosine kinase ligand functional selectivity: Trk-B case study	12
Excitation energy transfer kinetics of trimeric, monomeric and subunit-depleted Photosystem I from Synechocystis PCC 6803	12
Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo	11
Resveratrol promotes lysosomal function via ER calcium-dependent TFEB activation to ameliorate lipid accumulation	11
Insight into the function of active site residues in the catalytic mechanism of human ferrochelatase	11
Mechanistic diversity in MHC class I antigen recognition	11
A conserved, buried cysteine near the P-site is accessible to cysteine modifications and increases ROS stability in the P-type plasma membrane H+-ATPase	11
A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner	11
Seasonal cold induces divergent structural/biochemical adaptations in different skeletal muscles of Columba livia: evidence for nonshivering thermogenesis in adult birds	11
PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target	11
Capturing the domain crosstalk in full length LRRK2 and LRRK2RCKW	11

Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds	11
Importance of tyrosine phosphorylation for transmembrane signaling in plants	11
Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?	10
Intelligent host engineering for metabolic flux optimisation in biotechnology	10
Temporal modulation of the NF-κB RelA network in response to different types of DNA damage	10
Understanding interleukin 11 as a disease gene and therapeutic target	10
Mechanisms of TNF-independent RIPK3-mediated cell death	10
C-type cytochrome-initiated reduction of bacterial lytic polysaccharide monooxygenases	10
Deubiquitinases in cell death and inflammation	10
Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI	10
The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors	10
Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η	10
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs	10
Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation	10
Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling	10
Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps	10
How many kinases are druggable? A review of our current understanding	10
Cryo-EM structures of the Synechocystis sp. PCC 6803 cytochrome b6f complex with and without the regulatory PetP subunit	10
Electron transfer via cytochrome b6f complex displays sensitivity to antimycin A upon STT7 kinase activation	10
Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin	9
Two routes of direct intercellular communication in brain cancer	9
Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes	9
AMPK inhibits liver gluconeogenesis: fact or fiction?	9
Altered intestinal epithelial nutrient transport: an underappreciated factor in obesity modulated by diet and microbiota	9
Crystal structures of ORFV125 provide insight into orf virus-mediated inhibition of apoptosis	9
Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment	9
Structural and functional organization of germ plasm condensates	9
PROTEIN l-ISOASPARTYL METHYLTRANSFERASE (PIMT) in plants: regulations and functions	9
The biochemistry and physiology of long-chain dicarboxylic acid metabolism	9
Diversity of ACE2 and its interaction with SARS-CoV-2 receptor binding domain	9
An ERK5–KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells	9
Characterizing crosstalk in epigenetic signaling to understand disease physiology	9
ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1	9
The mitochondrial translocator protein (TSPO): a key multifunctional molecule in the nervous system	9
Transforming growth factor-β2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE	9
Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth	9
Structure-based drug repurposing to inhibit the DNA gyrase of Mycobacterium tuberculosis	9
Identification of an l-serine/l-threonine dehydratase with glutamate racemase activity in mammals	9
Syntaxins 6 and 8 facilitate tau into secretory pathways	9
Structures of an engineered phospholipase D with specificity for secondary alcohol transphosphatidylation: insights into plasticity of substrate binding and activation	9
PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability	9
Reprogramming the tumor metastasis cascade by targeting galectin-driven networks	9
Phase transition of fibrillarin LC domain regulates localization and protein interaction of fibrillarin	9
The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice	9
Conformational plasticity of the ULK3 kinase domain	9
The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?	9
From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I	9
Complexin-2 redistributes to the membrane of muscle cells in response to insulin and contributes to GLUT4 translocation	9
Nutrient transceptors physically interact with the yeast S6/protein kinase B homolog, Sch9, a TOR kinase target	8
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator	8
The unfolding role of ceramide in coordinating retinoid-based cancer therapy	8
Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions	8
Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development	8
Structural and molecular bases to IRE1 activity modulation	8
Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance	8
Exploring the roles of microbes in facilitating plant adaptation to climate change	8
From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics	8
FoxA2 and RNA Pol II mediate human islet amyloid polypeptide turnover in ER-stressed pancreatic β-cells	8
Stability of Smyd1 in endothelial cells is controlled by PML-dependent SUMOylation upon cytokine stimulation	8
Structure of an open conformation of T7 DNA polymerase reveals novel structural features regulating primer-template stabilization at the polymerization active site	8
Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity	8
Crystal structure of Leptospira leucine-rich repeat 20 reveals a novel E-cadherin binding protein to induce NGAL expression in HK2 cells	8
Nanobodies against Pfs230 block Plasmodium falciparum transmission	8
An Arabidopsis thaliana arabinogalactan-protein (AGP31) and several cationic AGP fragments catalyse the boron bridging of rhamnogalacturonan-II	8
Conformational changes during the reaction cycle of Plasma Membrane Ca2+-ATPase in the autoinhibited and activated states	8
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth	8
Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC	8
Appropriate aglycone modification significantly expands the glycan substrate acceptability of α1,6-fucosyltransferase (FUT8)	8
MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins	8
Stepwise oxidations play key roles in the structural and functional regulations of DJ-1	8
Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12	7
Nanobody generation and structural characterization of Plasmodium falciparum 6-cysteine protein Pf12p	7
Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7	7
Conformational trapping of an ABC transporter in polymer lipid nanoparticles	7
Per aspera ad chaos: a personal journey to the wonderland of intrinsic disorder	7
Interaction of the periplasmic chaperone SurA with the inner membrane protein secretion (SEC) machinery	7
Binding partners regulate unfolding of myosin VI to activate the molecular motor	7
Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1	7
Proteomic analysis identifies ZMYM2 as endogenous binding partner of TBX18 protein in 293 and A549 cells	7
Principles of phosphoproteomics and applications in cancer research	7
FATP4 inactivation in cultured macrophages attenuates M1- and ER stress-induced cytokine release via a metabolic shift towards triacylglycerides	7
Mapping the interaction surface of scorpion β-toxins with an insect sodium channel	7
Improved furfural tolerance in Escherichia coli mediated by heterologous NADH-dependent benzyl alcohol dehydrogenases	7
Regulation of B cell receptor signalling by Epstein–Barr virus nuclear antigens	7
A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects	7
Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance	7
Elevated CO2 alters photosynthesis, growth and susceptibility to powdery mildew of oak seedlings	7
Key allosteric and active site residues of SARS-CoV-2 3CLpro are promising drug targets	7
Diversified amino acid-mediated allosteric regulation of phosphoglycerate dehydrogenase for serine biosynthesis in land plants	7
Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions	7
Allosteric pluripotency: challenges and opportunities	7
Quantitative live-cell imaging of GPCR downstream signaling dynamics	7
Quantitative metabolic fluxes regulated by trans-omic networks	7
NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes	7
Common and unique features of glycosylation and glycosyltransferases in African trypanosomes	7