Biochemical Journal

Article	Citations
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells	791
Respiratory epithelial cell types, states and fates in the era of single-cell RNA-sequencing	191
Michael D. Waterfield	161
A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity	124
Insights into the substrate discrimination mechanisms of methyl-CpG-binding domain 4	92
Combinatorial approaches for mitigating resistance to KRAS-targeted therapies	90
Development of an OTUD1 ubiquitin variant inhibitor	79
Conformational plasticity of the ULK3 kinase domain	64
Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast	64
A curated list of targeted optimized promiscuous ketoreductases (TOP-K)	63
Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor	58
In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity	57
The breakthrough in protein structure prediction	54
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane	54
Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif	52
Programmed cell death: the pathways to severe COVID-19?	51
GlmS mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum	51
A guide to ERK dynamics, part 2: downstream decoding	48
Calcium signalling components underlying NPK homeostasis: potential avenues for exploration	48
Internalization and membrane activity of the antimicrobial peptide CGA-N12	47
Improved furfural tolerance in Escherichia coli mediated by heterologous NADH-dependent benzyl alcohol dehydrogenases	46
Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition	44
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome	43
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses	42
The atypical thioredoxin ‘Alr2205’, a newly identified partner of the typical 2-Cys-Peroxiredoxin, safeguards the cyanobacterium Anabaena from oxidative stress	42

CORM-3 induces DNA damage through Ru(II) binding to DNA	42
Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice	41
BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia	41
From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease	40
The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination	39
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders	38
Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation	38
TOR complex 2 is a master regulator of plasma membrane homeostasis	37
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications	36
Cryo-EM structure of human MG53 homodimer	35
Interactions between insulin and exercise	35
Retraction: Lead induces the upregulation of protein arginine methyltransferase 5 possibly by its promoter demethylation	35
Expression of Concern: Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway	34
Identification and characterization of the Doublesex gene and its mRNA isoforms in the brine shrimp Artemia franciscana	33
The role of mitochondrial RNA association for mitochondrial homeostasis in neurons	33
RhoGAP6 interacts with COPI to regulate protein transport	32
Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?	31
Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues	31
Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions	30
Sequence variation in the active site of mobile colistin resistance proteins is evolutionarily accommodated through inter-domain interactions	30
Characterization of tolloid-mediated cleavage of the GDF8 procomplex	29
Towards ‘end-to-end’ analysis and understanding of biological timecourse data	29
Correction: Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity.	28
FoxO transcription factors in mitochondrial homeostasis	28
Stress-induced activation of receptor signaling by protease-mediated cleavage	28
Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex	28
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator	27
Correction: The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h	27
Protein kinase A and local signaling in cancer	27
Opposing forces fight over the same ground to regulate interferon signaling	27
The uncharacterized protein ZNF200 interacts with PRMT3 and aids its stability and nuclear translocation	26
NAD-catabolizing ectoenzymes of Schistosoma mansoni	26
Structure and function of MDM2 and MDM4 in health and disease	26
Gibberellin-biosynthetic ent-kaurene synthases in higher plants do not require their non-catalytic domains for the catalysis	25
Thermodynamic analysis of Zα domain-nucleic acid interactions	25
Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling	25
GLUT4 On the move	24
Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway	24
Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis	23
Conservation of endo-glucanase 16 (EG16) activity across highly divergent plant lineages	23
Insight into the function of active site residues in the catalytic mechanism of human ferrochelatase	22
Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway	22
Retraction: Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure	21
The structure and function of modular Escherichia coli O157:H7 bacteriophage FTBEc1 endolysin, LysT84: defining a new endolysin catalytic subfamily	21
Ubiquitin E3 ligases in the plant Arg/N-degron pathway	20
Yop1 stability and membrane curvature generation propensity are controlled by its oligomerisation interface	20
MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins	20
Adapting to change: resolving the dynamic and dual roles of NCK1 and NCK2	20
Targeting bacterial degradation machinery as an antibacterial strategy	20
On the specificity of protein–protein interactions in the context of disorder	20

Retraction: Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin	20
Functional insights into Mycobacterium tuberculosis DevR-dependent transcriptional machinery utilizing Escherichia coli	19
Leukotriene B4 receptor 1 does not mediate disease progression in a mouse model of liver fibrosis	19
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease	19
Elevated CO2 alters photosynthesis, growth and susceptibility to powdery mildew of oak seedlings	19
CLN5 and CLN3 function as a complex to regulate endolysosome function	19
Exopolysaccharide is detrimental for the symbiotic performance of Sinorhizobium fredii HH103 mutants with a truncated lipopolysaccharide core	19
Recognition and repair of oxidatively generated DNA lesions in plasmid DNA by a facilitated diffusion mechanism	18
Structure of an open conformation of T7 DNA polymerase reveals novel structural features regulating primer-template stabilization at the polymerization active site	18
Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system	18
IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesicles	17
The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors	17
From the Belousov–Zhabotinsky reaction to biochemical clocks, traveling waves and cell cycle regulation	17
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth	17
Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2	17
Distinct interactors define the p63 transcriptional signature in epithelial development or cancer	17
PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target	17
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity	16
Transforming growth factor-β2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE	16
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlierAtITPK4	16
Abscisic acid triggers vitamin E accumulation by transient transcript activation of VTE5 and VTE6 in sweet cherry fruits	16
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin	16
Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery	16
Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes	15
Activation and manipulation of inflammasomes and pyroptosis during bacterial infections	15
Proteomic mapping and optogenetic manipulation of membrane contact sites	15
TAT–RHIM: a more complex issue than expected	15
Per aspera ad chaos: a personal journey to the wonderland of intrinsic disorder	15
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	15
Kinases leave their mark on caspase substrates	14
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway	14
A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy	14
Genetic modulation of CWD prion propagation in cervid PrP Drosophila	14
DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability	14
Sequence rules for a long SPOP-binding degron required for protein ubiquitylation	14
Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity	14
Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5	14
Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain	14
Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity	14
Macropinocytosis: mechanisms and regulation	13
Importance of tyrosine phosphorylation for transmembrane signaling in plants	13
Correction: NAD+-consuming enzymes in immune defense against viral infection	13
The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms	13
Genome damage accumulated in seed ageing leads to plant genome instability and growth inhibition	13
Flavin oxidation state impacts on nitrofuran antibiotic binding orientation in nitroreductases	13
Dynamic interchange of local residue–residue interactions in the largely extended single alpha-helix in Drebrin	13
PHF1 compartmentalizes PRC2 via phase separation	13
The impact of cell states on heterochromatin dynamics	13
Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation	12
The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase	12
Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention	12
The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii	12
Synthesis, biochemical characterization and in silico investigation of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid derivatives: dual action mode inhibitors of urease and virulent bacterial	12
Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8	12
The role of the γ subunit in the photosystem of the lowest-energy phototrophs	12
The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes	12
The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death	11
Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases	11
Beyond protein modification: the rise of non-canonical ADP-ribosylation	11
Structure of plant photosystem I-plastocyanin complex reveals strong hydrophobic interactions	11
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase	11
Common and unique features of glycosylation and glycosyltransferases in African trypanosomes	11
Mechanistic diversity in MHC class I antigen recognition	11
The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?	11
Plant adaptation to climate change	11
Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2	11
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing	11
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation	11
The many ways that nature has exploited the unusual structural and chemical properties of phosphohistidine for use in proteins	11
ISGylation-independent protection of cell growth by USP18 following interferon stimulation	10
Characterization of ADAT2/3 molecules in Trypanosoma cruzi and regulation of mucin gene expression by tRNA editing	10
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965	10
Shaping mitochondria through fed–fast and circadian cycles	10
Cancer stem cell phosphatases	10
Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity	10
RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers	10
Entangling roles of cholesterol-dependent interaction and cholesterol-mediated lipid phase heterogeneity in regulating listeriolysin O pore-formation	10
LMBD1 protein participates in cell mitosis by regulating microtubule assembly	10
Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma	10
Revamped Role for Approved Drug: Integrative Computational and Biophysical Analysis of Saquinavir's PAD4 Inhibition for Rheumatoid Arthritis	10

The monodomain Kunitz protein EgKU-7 from the dog tapeworm Echinococcus granulosus is a high-affinity trypsin inhibitor with two interaction sites	10
Integrin αVβ1 regulates procollagen I production through a non-canonical transforming growth factor β signaling pathway in human hepatic stellate cells	9
LASP-1 interacts with ErbB2 in ovarian cancer cells	9
Loss of peroxiredoxin 6 alters lipid composition and distribution resulting in increased sensitivity to ferroptosis	9
The NFkB activation domain is 14-amino-acid-long variant of the 9aaTAD	9
The roles of epigenetics in cancer progression and metastasis	9
Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase	9
Root system growth and development responses to elevated CO2: underlying signalling mechanisms and role in improving plant CO2 capture and soil C storage	9
Skin in the game: pannexin channels in healthy and cancerous skin	9
Molecular mechanisms of mammalian autophagy	9
Site IQ in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions	9
Correction: Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition	9
Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs	9
TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells	9
α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif	9
Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG)	9
Regulation of Rubisco activity by interaction with chloroplast metabolites	9
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2α phosphorylation	8
Quantitative metabolic fluxes regulated by trans-omic networks	8
Structural and molecular bases to IRE1 activity modulation	8
The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors	8
Translational regulation in pathogenic and beneficial plant–microbe interactions	8
Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	8
Chilling or chemical induction of dormancy release in blackcurrant (Ribes nigrum) buds is associated with characteristic shifts in metabolite profiles	8
Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice	8
Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia	8
Biochemical investigations of polyphenol degradation enzymes in the phototrophic bacterium Rubrivivax gelatinosus	8
The role of phosphorylation in calmodulin-mediated gating of human AQP0	8
Ferroptosis in plants: regulation of lipid peroxidation and redox status	8
Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in Streptococcus pneumoniae and displays anti-pneumococcal activity	8
NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes	8
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease	8
Excess iodide-induced reactive oxygen species elicit iodide efflux via β-tubulin-associated ClC-3 in thyrocytes	8
Pyroptotic executioner pore-forming protein gasdermin D forms oligomeric assembly and exhibits amyloid-like attributes that could contribute for its pore-forming function	8
Into the fold: advances in understanding aPKC membrane dynamics	8
Intelligent host engineering for metabolic flux optimisation in biotechnology	8
Casting iron into the cell fate mold	8
Current data processing strategies for cryo-electron tomography and subtomogram averaging	8
Systems approaches to investigate the role of NF-κB signaling in aging	8
Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly	7
Telomerase RNA evolution: a journey from plant telomeres to broader eukaryotic diversity	7
Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy	7
Long-range electron proton coupling in respiratory complex I — insights from molecular simulations of the quinone chamber and antiporter-like subunits	7
Enhanced plant-microbe remediation of PCBs in soil using enzyme modification technique combined with molecular docking and molecular dynamics	7
Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity	7
Protein targeting by the itaconate family in immunity and inflammation	7
Understanding amphisomes	7
Conserved L464 in p97 D1–D2 linker is critical for p97 cofactor regulated ATPase activity	7
Activating mutations drive human MEK1 kinase using a gear-shifting mechanism	7
A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes	7
Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity	7
An all-out assault on SARS-CoV-2 replication	7
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate	7
The genetic and molecular basis of a connexin-linked skin disease	7
The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii	7
Histone mimics: more tales to read	7
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors	7
Dynamic interactions between SPX proteins, the ubiquitination machinery, and signalling molecules for stress adaptation at a whole-plant level	7
The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress	7
E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease	6
From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I	6
NAD+-consuming enzymes in immune defense against viral infection	6
Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing	6
Inhibition of RIPK1 or RIPK3 kinase activity post ischemia-reperfusion reduces the development of chronic kidney injury	6
Exploring the dynamics and interactions of the N-myc transactivation domain through solution nuclear magnetic resonance spectroscopy	6
Sperm induce a secondary increase in ATP levels in mouse eggs that is independent of Ca2+ oscillations	6
Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes	6
AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue	6
Correction: Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366	6
N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum	6
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding	6
Comparative analysis of canine and human HtrA2 to delineate its role in apoptosis and cancer	6
Short- and long-term warming events on photosynthetic physiology, growth, and yields of field grown crops	6
The function of BK channels extracted and purified within SMALPs	6
Understanding interleukin 11 as a disease gene and therapeutic target	6
Regulation of the mitotic chromosome folding machines	6
Development of circadian rhythms in mammalian systems	6
Mitophagy in yeast: known unknowns and unknown unknowns	6
Paraquat resistance mutations have differential effects on plant fitness in two rice cultivars	6
Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity	6
Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7	6
UBE2A/B is the trans-acting factor mediating mechanotransduction and contact inhibition	6
Sulfoquinovosyl diacylglycerol is required for dimerisation of the Rhodobacter sphaeroides reaction centre-light harvesting 1 core complex	6
Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine	6
An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperatures	6
Cryo-EM structure of the monomeric Rhodobacter sphaeroides RC–LH1 core complex at 2.5 Å	6
How do cells stiffen?	6
Correction: Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s	6
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death	6
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach	6
Photoaffinity labelling displacement assay using multiple recombinant protein domains	5
Integration of machine learning with computational structural biology of plants	5
Activin E is a transforming growth factor β ligand that signals specifically through activin receptor-like kinase 7	5
Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development	5
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain	5