OOIR: Observatory of International Research

Papers

(The median citation count of Clinical & Experimental Metastasis is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
The value of case reports in rare oncological scenarios: mixed method analysis of colorectal metastases from breast cancer	67
Congratulations to Prof. em. Garth L. Nicolson – co-founder of Clinical & Experimental Metastasis	57
Personalized therapy in oncology: melanoma as a paradigm for molecular-targeted treatment approaches	54
Donald L. Morton Memorial Lecture: the legacy of Donald Morton: past, present and future	45
The lymphatic system and sentinel lymph nodes: conduit for cancer metastasis	39
Immunotherapy of cancer in the era of checkpoint inhibitor	34
Detection of melanoma, breast cancer and head and neck squamous cell cancer sentinel lymph nodes by Tc-99m Tilmanocept (Lymphoseek®)	33
Emerging photoacoustic and thermoacoustic imaging technologies for detecting primary and metastatic cancer and guiding therapy	29
The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study	29
Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models	29
Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancer	29
Portal vein tumor thrombosis in hepatocellular carcinoma: molecular mechanism and therapy	28
Prostate cancer addiction to oxidative stress defines sensitivity to anti-tumor neutrophils	26
Detection of sentinel lymph nodes by tilmanocept in oral squamous cell carcinoma	24
Killing two birds with a stone: how to maximise benefit from metastasis-directed therapy and modern systemic treatment in oligometastatic hormone sensitive prostate cancer	24
Prospective assessment of AR splice variant and PSMA detection on circulating tumor cells of mCRPC patients: preliminary analysis of patients enrolled in PRIMERA trial (NCT04188275)	23
Intraperitoneal drug delivery systems releasing cytostatic agents to target gastro‐intestinal peritoneal metastases in laboratory animals: a systematic review	18
Nanoparticles loaded with circ_0086375 for suppressing the tumorigenesis of pancreatic cancer by targeting the miR-646/SLC4A4 axis	18
EGFL6 promotes bone metastasis of lung adenocarcinoma by increasing cancer cell malignancy and bone resorption	18
Cancer neoantigens as potential targets for immunotherapy	17
Cutting-edge innovations in breast cancer diagnosis- the potential of HDMI biomarkers	16
Efficacy and safety of thoracic radiotherapy for extensive stage small cell lung cancer after immunotherapy in real world	16
Current status of gastrointestinal tract cancer brain metastasis and the use of blood-based cancer biomarker biopsy	15
Stereotactic body radiation therapy for adrenal gland metastases: outcome and predictive factors from a multicenter analysis	14
Cancer heterogeneity and metastasis: life at the edge	14

Molecular and cellular mechanisms controlling integrin-mediated cell adhesion and tumor progression in ovarian cancer metastasis: a review	14
The gastrointestinal microbiota in colorectal cancer cell migration and invasion	14
Development and characterization of a rat brain metastatic tumor model by multiparametric magnetic resonance imaging and histomorphology	14
Type IV collagen as a potential biomarker of metastatic breast cancer	13
Multiple myeloma: clinical characteristics, current therapies and emerging innovative treatments targeting ribosome biogenesis dynamics	12
Pulmonary lysyl oxidase expression and its role in seeding Lewis lung carcinoma cells	12
Multi-marker analysis of circulating tumor cells in localized intermediate/high-risk and metastatic prostate cancer	12
Factors associated with the distribution of brain metastases in lung cancer: a retrospective study	12
The effect of the low stromal ratio induced by neoadjuvant chemotherapy on recurrence patterns in borderline resectable pancreatic ductal adenocarcinoma	11
Microarray-based detection and expression analysis of drug resistance in an animal model of peritoneal metastasis from colon cancer	11
PIM3 kinase promotes tumor metastasis in hepatoblastoma by upregulating cell surface expression of chemokine receptor cxcr4	11
Application of CTC discoveries for liquid biopsy: the RPL/RPS gene signature of melanoma CTCs is linked to brain metastasis onset	11
Breast cancer disparities in outcomes; unmasking biological determinants associated with racial and genetic diversity	10
LITAF inhibits colorectal cancer stemness and metastatic behavior by regulating FOXO1-mediated SIRT1 expression	10
PET/CT in assessment of colorectal liver metastases: a comprehensive review with emphasis on 18F-FDG	10
In-transit metastatic cutaneous melanoma: current management and future directions	10
Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels	10
Stereotactic radiotherapy for liver oligometastases: a pooled analysis following the estro/eortc consensus recommendations	10
The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria	10
Secondary lymphedema from cancer therapy	10
Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance	10
Targeting CD44 and other pleiotropic co-receptors as a means for broad inhibition of tumor growth and metastasis	10
Prediction of transformation in the histopathological growth pattern of colorectal liver metastases after chemotherapy using CT-based radiomics	9
A new Neu—a syngeneic model of spontaneously metastatic HER2-positive breast cancer	9
Predictive value of 18 F-FDG PET/CT versus bone marrow biopsy and aspiration in pediatric neuroblastoma	9
Correction: Predictive value of 18 F-FDG PET/CT versus bone marrow biopsy and aspiration in pediatric neuroblastoma	9
‘Sandwich treatment’ for posterior fossa brain metastases with volume larger than 4cm3: a multicentric retrospective study	8
Novel approach involving stereotactic body radiotherapy followed by intramedullary nail placement for long bone metastases: a case report	8
Introduction: Novel Frontiers in Cancer Metastasis	8
CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells	8
Innovations in radiotherapy and advances in immunotherapy for the treatment of brain metastases	8
Bringing precision oncology to cellular resolution with single-cell genomics	8
Letter: Estimating the baseline local recurrence rate for a brain metastasis after neurosurgical resection	8
Serum conversion pattern of SCC-Ag levels between pre- and post-chemoradiotherapy predicts recurrence and metastasis in cervical cancer: a multi-institutional analysis	8
Should EUS-FNA be considered also for the diagnosis of peripheral small pulmonary lesions?	8
The smac mimetic LCL161 targets established pulmonary osteosarcoma metastases in mice	8
Acetone compression improves lymph node yield and metastasis detection in colorectal cancer	7
Role of CD44 isoforms in epithelial-mesenchymal plasticity and metastasis	7
Preoperative embolization of renal cell carcinoma metastases to the bone prior to stabilization procedures does not result in reduction in intraoperative blood loss	7
Early biochemical outcomes following PSMA guided approach for bIoCHEmical relapse after prostatectomy-PSICHE trial (NCT05022914): preliminary results	7
Molecular prognostic indicators in HPV-positive oropharyngeal cancer: an updated review	7
Clinical applications of circulating tumor cells in patients with solid tumors	7
Beta-blocker adjunct therapy as a prospective anti-metastatic with cardio-oncologic regulation	7
Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice	7
Stereotactic body radiotherapy for spinal oligometastases: a survey on patterns of practice on behalf of the Italian Association of Clinical Oncology and Radiotherapy (AIRO)	6
Long non-coding RNA NRSN2-AS1, transcribed by SOX2, promotes progression of esophageal squamous cell carcinoma by regulating the ubiquitin-degradation of PGK1	6
Characterizing perfusion defects in metastatic lymph nodes at an early stage using high-frequency ultrasound and micro-CT imaging	6
Neoadjuvant therapy for resectable melanoma	6
Cancer metastasis through the lymphatic versus blood vessels	6
The role of host response to chemotherapy: resistance, metastasis and clinical implications	6

Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis	6
Current pharmacologic treatment of brain metastasis in non-small cell lung cancer	6
Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics	6
Interrogating the roles of lymph node metastasis in systemic immune surveillance	6
Oncolytic intralesional therapy for metastatic melanoma	6
Brain metastases from hepatopancreatobiliary malignancies	5
New perspectives in unresectable cholangiocarcinoma? Evaluation of chemosaturation with percutaneous hepatic perfusion as a palliative treatment option	5
Histopathological growth patterns of resected non-colorectal, non-neuroendocrine liver metastases: a retrospective multicenter study	5
Endobronchial ultrasound-guided transbronchial needle aspiration in peripheral pulmonary lesions: a systematic review and meta-analysis	5
Inhibition of LPS-mediated TLR4 activation abrogates gastric adenocarcinoma-associated peritoneal metastasis	5
Single‐fraction versus hypofractionated gamma knife radiosurgery for small metastatic brain tumors	5
Correction to: Editorial: Cancer metastasis through the lymphovascular system: molecular mechanisms of cancer metastasis	5
Lymph nodes in oral squamous cell carcinoma: a comprehensive anatomical perspective	5
Stereotactic body radiotherapy to lymph nodes in oligoprogressive castration-resistant prostate cancer patients: a post hoc analysis from two phase I clinical trials	5
ADC textural features in patients with single brain metastases improve clinical risk models	5
Targeting PADI2 as a potential therapeutic strategy against metastasis in oral cancer via suppressing EMT-mediated migration and invasion and CCL3/5-induced angiogenesis	4
Forty years on: a brief history of clinical and experimental metastasis	4
PD-L1 and VEGF dual blockade enhances anti-tumor effect on brain metastasis in hematogenous metastasis model	4
International cooperation to fight cancer’s late-stage presentation in low- and middle-income countries	4
Cell blebbing novel therapeutic possibilities to counter metastasis	4
Establishment and Image based evaluation of a New Preclinical Rat Model of Osteoblastic Bone Metastases	4
CD276 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma through the TGF-β/SMAD signaling	3
PD-L1 blockade exhibits anti-tumor effect on brain metastasis by activating CD8+ T cells in hematogenous metastasis model with lymphocyte infusion	3
Editorial: Novel Frontiers in Cancer Metastasis	3
High sensitivity flow cytometry immunophenotyping increases the diagnostic yield of malignant pleural effusions	3
Data mining of key genes expression in hepatocellular carcinoma: novel potential biomarkers of diagnosis prognosis or progression	3
Circulating tumour cells are associated with histopathological growth patterns of colorectal cancer liver metastases	3
Cancer cell metabolic plasticity in migration and metastasis	3
Pembrolizumab in patients with advanced upper tract urothelial carcinoma: a real-world study from ARON-2 project	3
Axillary nodal staging in breast cancer: what have we learned?	3
Wnt/β-catenin/Slug pathway contributes to tumor invasion and lymph node metastasis in head and neck squamous cell carcinoma	3
SBRT for elderly oligometastatic patients as a feasible, safe and effective treatment opportunity	3
Cancer microenvironment and genomics: evolution in process	3
Stereotactic body radiotherapy (SBRT) and concomitant systemic therapy in oligoprogressive breast cancer patients	3
Risk factors for surgical site infection and association of surgical site infection with survival of lower rectal cancer patients without clinical lateral pelvic lymph node metastasis (clinical Stage	3
Mapping the single cell spatial immune landscapes of the melanoma microenvironment	3
Cardiooncology—dealing with modern drug treatment, long-term complications, and cancer survivorship	3
Protective measures for patients with advanced cancer during the Sars-CoV-2 pandemic: Quo vadis?	3
The role of stereotactic body radiation therapy and its integration with systemic therapies in metastatic kidney cancer: a multicenter study on behalf of the AIRO (Italian Association of Radiotherapy	3
Treating colorectal peritoneal metastases with an injectable cytostatic loaded supramolecular hydrogel in a rodent animal model	3
Correction to: Assessment of incentivizing effects for cancer care frameworks	2
Molecular mechanisms of sensitivity and resistance to radiotherapy	2
Comparison of trastuzumab emtansine, trastuzumab deruxtecan, and disitamab vedotin in a multiresistant HER2-positive breast cancer lung metastasis model	2
Hepatic arterial infusion with nanoliposomal irinotecan leads to significant regression of tumor size of colorectal liver metastases in a CC531 rat model	2
Travelling under pressure - hypoxia and shear stress in the metastatic journey	2
Topography and probability diagram of cervical and intra-parotid lymph node metastasis in parotid gland cancer	2
PITX1 suppresses osteosarcoma metastasis through exosomal LINC00662-mediated M2 macrophage polarization	2
Current challenges in metastasis research and future innovation for clinical translation	2
How much do we know about the metastatic process?	2
Collective metastasis: coordinating the multicellular voyage	2
Future perspectives: Novel Frontiers in Cancer Metastasis	2
Introduction to novel developments in radio-imaging and radiotherapy	2
Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases	2
Correction to: PITX1 suppresses osteosarcoma metastasis through exosomal LINC00662-mediated M2 macrophage polarization	2
Platycodin D represses β-catenin to suppress metastasis of cetuximab-treated KRAS wild-type colorectal cancer cells	2
Establishing patient-derived tumor organoids of bone metastasis from lung adenocarcinoma reveals the transcriptomic changes underlying denosumab treatment	2
Mechanisms of breast cancer metastasis	2
Sentinel lymph node biopsy in melanoma: beyond histologic factors	2
Osteoclasts directly influence castration-resistant prostate cancer cells	2