OOIR: Observatory of International Research

Papers

(The median citation count of Clinical & Experimental Metastasis is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Congratulations to Prof. em. Garth L. Nicolson – co-founder of Clinical & Experimental Metastasis	55
LITAF inhibits colorectal cancer stemness and metastatic behavior by regulating FOXO1-mediated SIRT1 expression	41
PET/CT in assessment of colorectal liver metastases: a comprehensive review with emphasis on 18F-FDG	32
Prediction of transformation in the histopathological growth pattern of colorectal liver metastases after chemotherapy using CT-based radiomics	30
EGFL6 promotes bone metastasis of lung adenocarcinoma by increasing cancer cell malignancy and bone resorption	28
Personalized therapy in oncology: melanoma as a paradigm for molecular-targeted treatment approaches	26
Multiple myeloma: clinical characteristics, current therapies and emerging innovative treatments targeting ribosome biogenesis dynamics	26
Letter: Estimating the baseline local recurrence rate for a brain metastasis after neurosurgical resection	25
Oncolytic intralesional therapy for metastatic melanoma	25
Preoperative embolization of renal cell carcinoma metastases to the bone prior to stabilization procedures does not result in reduction in intraoperative blood loss	25
The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria	25
Cell blebbing novel therapeutic possibilities to counter metastasis	20
High sensitivity flow cytometry immunophenotyping increases the diagnostic yield of malignant pleural effusions	19
Topography and probability diagram of cervical and intra-parotid lymph node metastasis in parotid gland cancer	19
Axillary nodal staging in breast cancer: what have we learned?	19
Correction: CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells	19
External validation of a red cell-based blood prognostic score in patients with metastatic renal cell carcinoma treated with first-line immunotherapy combinations	17
Therapy resistance and metastasis	16
Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer	16
CT-based deep learning model: a novel approach to the preoperative staging in patients with peritoneal metastasis	16
Editorial: Cancer metastasis through the lymphovascular system: molecular mechanisms of cancer metastasis	15
Current preclinical models of brain metastasis	14
Clinical characteristics, treatment, and long-term outcome of patients with brain metastases from thyroid cancer	14
Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker	13
Effect of liver metastasis on the efficacy of immune checkpoint inhibitors in cancer patients: a systemic review and meta-analysis	13

Antigen presenting cells in cancer immunity and mediation of immune checkpoint blockade	13
Histopathological growth patterns of neuroendocrine tumor liver metastases	12
Correction: SETBP1 activation upon MDM4-enhanced ubiquitination of NR3C1 triggers dissemination of colorectal cancer cells	11
Tumor microenvironment dynamics in oral cancer: unveiling the role of inflammatory cytokines in a syngeneic mouse model	11
The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study	10
Etiology and treatment of cancer-related secondary lymphedema	10
Should EUS-FNA be considered also for the diagnosis of peripheral small pulmonary lesions?	10
Nanoparticles loaded with circ_0086375 for suppressing the tumorigenesis of pancreatic cancer by targeting the miR-646/SLC4A4 axis	10
Stereotactic radiotherapy for liver oligometastases: a pooled analysis following the estro/eortc consensus recommendations	10
Efficacy and safety of PARPis combined with an ICIs for advanced or metastatic triple-negative breast cancer: a single-arm meta-analysis	10
‘Sandwich treatment’ for posterior fossa brain metastases with volume larger than 4cm3: a multicentric retrospective study	9
Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics	9
Beta-blocker adjunct therapy as a prospective anti-metastatic with cardio-oncologic regulation	9
Targeting PADI2 as a potential therapeutic strategy against metastasis in oral cancer via suppressing EMT-mediated migration and invasion and CCL3/5-induced angiogenesis	9
Early biochemical outcomes following PSMA guided approach for bIoCHEmical relapse after prostatectomy-PSICHE trial (NCT05022914): preliminary results	9
Multi-institutional study using sbrt to treat mediastinal and hilar lymphadenopathy	9
Impact of time-of-day administration of immunotherapy on survival in metastatic renal cell carcinoma: the MOUSEION-09 meta-analysis	8
Differentiation of benign and metastatic lymph nodes in soft tissue sarcoma	8
Prognostic impact of EGFR/ALK alterations in leptomeningeal metastasis from lung adenocarcinoma treated with whole-brain radiotherapy	8
Computational markers for personalized prediction of outcomes in non-small cell lung cancer patients with brain metastases	8
Trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody–drug conjugate, demonstrates in vitro and in vivo antitumor activity against primary and metastatic ovarian tumors overexpressing HER2	8
Correction: Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival	8
Immune responses and immunotherapeutic approaches in the treatment against cancer	8
Stereotactic radiotherapy of nodal oligometastases from prostate cancer: a prisma-compliant systematic review	7
Bromodomain inhibition targeting BPTF in the treatment of melanoma and other solid tumors	7
Interrogating the roles of lymph node metastasis in systemic immune surveillance	7
Killing two birds with a stone: how to maximise benefit from metastasis-directed therapy and modern systemic treatment in oligometastatic hormone sensitive prostate cancer	7
Application of CTC discoveries for liquid biopsy: the RPL/RPS gene signature of melanoma CTCs is linked to brain metastasis onset	7
Microarray-based detection and expression analysis of drug resistance in an animal model of peritoneal metastasis from colon cancer	7
TGFβ signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer	7
Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance	7
Correction to: Editorial: Cancer metastasis through the lymphovascular system: molecular mechanisms of cancer metastasis	7
CD276 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma through the TGF-β/SMAD signaling	6
Metastatic sites and clinical outcomes in renal cell carcinoma patients receiving immune-based combinations: the MOUSEION-08 study	6
Management of melanoma: can we use gene expression profiling to help guide treatment and surveillance?	6
miRNAs in pancreatic cancer progression and metastasis	6
Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis	6
Establishing patient-derived tumor organoids of bone metastasis from lung adenocarcinoma reveals the transcriptomic changes underlying denosumab treatment	6
International cooperation to fight cancer’s late-stage presentation in low- and middle-income countries	6
Correction: Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer	6
Membrane Lipid Replacement for reconstituting mitochondrial function and moderating cancer-related fatigue, pain and other symptoms while counteracting the adverse effects of cancer cytotoxic therapy	6
Platycodin D represses β-catenin to suppress metastasis of cetuximab-treated KRAS wild-type colorectal cancer cells	6
CD44 in Bone Metastasis Development: A Key Player in the Fate Decisions of the Invading Cells?	6
Detecting and monitoring tumors in orthotopic colorectal liver metastatic animal models with high-resolution ultrasound	6
Associations amongst genes, molecules, cells, and organs in breast cancer metastasis	6
Mapping the single cell spatial immune landscapes of the melanoma microenvironment	5
Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases	5
Cancer metastasis through the lymphatic versus blood vessels	5
Intraperitoneal drug delivery systems releasing cytostatic agents to target gastro‐intestinal peritoneal metastases in laboratory animals: a systematic review	5
A new Neu—a syngeneic model of spontaneously metastatic HER2-positive breast cancer	5

Stereotactic body radiotherapy for spinal oligometastases: a survey on patterns of practice on behalf of the Italian Association of Clinical Oncology and Radiotherapy (AIRO)	5
Brain metastases from hepatopancreatobiliary malignancies	5
Surgical resection versus stereotactic radiosurgery for the treatment of brain metastases in the motor cortex; a meta-analysis and systematic review	5
Repurposing fluphenazine to suppress melanoma brain, lung and bone metastasis by inducing G0/G1 cell cycle arrest and apoptosis and disrupting autophagic flux	5
Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancer	5
Multi-marker analysis of circulating tumor cells in localized intermediate/high-risk and metastatic prostate cancer	5
Current pharmacologic treatment of brain metastasis in non-small cell lung cancer	5
Clinical applications of circulating tumor cells in patients with solid tumors	5
Treating colorectal peritoneal metastases with an injectable cytostatic loaded supramolecular hydrogel in a rodent animal model	5
Comparison of ex vivo bioluminescence imaging, Alu-qPCR and histology for the quantification of spontaneous lung and bone metastases in subcutaneous xenograft mouse models	5
Belvarafenib penetrates the BBB and shows potent antitumor activity in a murine melanoma brain metastasis model	5
Efficacy and safety of thoracic radiotherapy for extensive stage small cell lung cancer after immunotherapy in real world	5
Neoadjuvant therapy for resectable melanoma	5
Factors associated with the distribution of brain metastases in lung cancer: a retrospective study	5
Portal vein tumor thrombosis in hepatocellular carcinoma: molecular mechanism and therapy	5