OOIR: Observatory of International Research

Papers

(The median citation count of Clinical & Experimental Metastasis is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Congratulations to Prof. em. Garth L. Nicolson – co-founder of Clinical & Experimental Metastasis	91
PET/CT in assessment of colorectal liver metastases: a comprehensive review with emphasis on 18F-FDG	67
LITAF inhibits colorectal cancer stemness and metastatic behavior by regulating FOXO1-mediated SIRT1 expression	66
Prediction of transformation in the histopathological growth pattern of colorectal liver metastases after chemotherapy using CT-based radiomics	52
Personalized therapy in oncology: melanoma as a paradigm for molecular-targeted treatment approaches	44
The effect of the low stromal ratio induced by neoadjuvant chemotherapy on recurrence patterns in borderline resectable pancreatic ductal adenocarcinoma	38
The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria	34
EGFL6 promotes bone metastasis of lung adenocarcinoma by increasing cancer cell malignancy and bone resorption	34
Detection of melanoma, breast cancer and head and neck squamous cell cancer sentinel lymph nodes by Tc-99m Tilmanocept (Lymphoseek®)	33
Multiple myeloma: clinical characteristics, current therapies and emerging innovative treatments targeting ribosome biogenesis dynamics	31
Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models	27
Stereotactic body radiotherapy to lymph nodes in oligoprogressive castration-resistant prostate cancer patients: a post hoc analysis from two phase I clinical trials	19
Letter: Estimating the baseline local recurrence rate for a brain metastasis after neurosurgical resection	19
Preoperative embolization of renal cell carcinoma metastases to the bone prior to stabilization procedures does not result in reduction in intraoperative blood loss	18
Oncolytic intralesional therapy for metastatic melanoma	18
Cell blebbing novel therapeutic possibilities to counter metastasis	17
Molecular prognostic indicators in HPV-positive oropharyngeal cancer: an updated review	17
Cardiooncology—dealing with modern drug treatment, long-term complications, and cancer survivorship	16
Risk factors for surgical site infection and association of surgical site infection with survival of lower rectal cancer patients without clinical lateral pelvic lymph node metastasis (clinical Stage	16
High sensitivity flow cytometry immunophenotyping increases the diagnostic yield of malignant pleural effusions	16
Therapy resistance and metastasis	15
Data mining of key genes expression in hepatocellular carcinoma: novel potential biomarkers of diagnosis prognosis or progression	15
Editorial: Cancer metastasis through the lymphovascular system: molecular mechanisms of cancer metastasis	15
Axillary nodal staging in breast cancer: what have we learned?	15
Correction: CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells	14

External validation of a red cell-based blood prognostic score in patients with metastatic renal cell carcinoma treated with first-line immunotherapy combinations	14
Clinical characteristics, treatment, and long-term outcome of patients with brain metastases from thyroid cancer	14
Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer	14
Topography and probability diagram of cervical and intra-parotid lymph node metastasis in parotid gland cancer	14
CT-based deep learning model: a novel approach to the preoperative staging in patients with peritoneal metastasis	13
Oligoprogressive castration-resistant prostate cancer treated with metastases-directed stereotactic body radiation therapy: predictive factors for patients’ selection	13
The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo	13
Antigen presenting cells in cancer immunity and mediation of immune checkpoint blockade	12
Current preclinical models of brain metastasis	12
Effect of liver metastasis on the efficacy of immune checkpoint inhibitors in cancer patients: a systemic review and meta-analysis	12
Fluid shear stress influences invasiveness of HeLa cells through the induction of autophagy	12
Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker	11
Histopathological growth patterns of neuroendocrine tumor liver metastases	11
Defining the landscape of metabolic dysregulations in cancer metastasis	11
Tumor microenvironment dynamics in oral cancer: unveiling the role of inflammatory cytokines in a syngeneic mouse model	11
Correction: SETBP1 activation upon MDM4-enhanced ubiquitination of NR3C1 triggers dissemination of colorectal cancer cells	11
The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study	10
Efficacy and safety of PARPis combined with an ICIs for advanced or metastatic triple-negative breast cancer: a single-arm meta-analysis	10
Etiology and treatment of cancer-related secondary lymphedema	10
Nanoparticles loaded with circ_0086375 for suppressing the tumorigenesis of pancreatic cancer by targeting the miR-646/SLC4A4 axis	10
Should EUS-FNA be considered also for the diagnosis of peripheral small pulmonary lesions?	9
Stereotactic radiotherapy for liver oligometastases: a pooled analysis following the estro/eortc consensus recommendations	9
Long non-coding RNA NRSN2-AS1, transcribed by SOX2, promotes progression of esophageal squamous cell carcinoma by regulating the ubiquitin-degradation of PGK1	9
Donald L. Morton Memorial Lecture: the legacy of Donald Morton: past, present and future	9
Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics	9
Early biochemical outcomes following PSMA guided approach for bIoCHEmical relapse after prostatectomy-PSICHE trial (NCT05022914): preliminary results	9
Beta-blocker adjunct therapy as a prospective anti-metastatic with cardio-oncologic regulation	9
Histopathological growth patterns of resected non-colorectal, non-neuroendocrine liver metastases: a retrospective multicenter study	8
Computational markers for personalized prediction of outcomes in non-small cell lung cancer patients with brain metastases	8
Targeting PADI2 as a potential therapeutic strategy against metastasis in oral cancer via suppressing EMT-mediated migration and invasion and CCL3/5-induced angiogenesis	8
Multi-institutional study using sbrt to treat mediastinal and hilar lymphadenopathy	8
‘Sandwich treatment’ for posterior fossa brain metastases with volume larger than 4cm3: a multicentric retrospective study	8
The role of stereotactic body radiation therapy and its integration with systemic therapies in metastatic kidney cancer: a multicenter study on behalf of the AIRO (Italian Association of Radiotherapy	8
Differentiation of benign and metastatic lymph nodes in soft tissue sarcoma	8
FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells	7
Trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody–drug conjugate, demonstrates in vitro and in vivo antitumor activity against primary and metastatic ovarian tumors overexpressing HER2	7
Bromodomain inhibition targeting BPTF in the treatment of melanoma and other solid tumors	7
Killing two birds with a stone: how to maximise benefit from metastasis-directed therapy and modern systemic treatment in oligometastatic hormone sensitive prostate cancer	7
Immune responses and immunotherapeutic approaches in the treatment against cancer	7
Correction: Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival	7
Less contrast-enhanced areas within lymph nodes in the delayed phase of contrast-enhanced MRI: a suspicious finding for lymph node metastases	7
Empowering study of breast cancer data with application of artificial intelligence technology: promises, challenges, and use cases	7
TGFβ signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer	7
Prognostic impact of EGFR/ALK alterations in leptomeningeal metastasis from lung adenocarcinoma treated with whole-brain radiotherapy	7
Stereotactic radiotherapy of nodal oligometastases from prostate cancer: a prisma-compliant systematic review	7
Microarray-based detection and expression analysis of drug resistance in an animal model of peritoneal metastasis from colon cancer	7
Impact of time-of-day administration of immunotherapy on survival in metastatic renal cell carcinoma: the MOUSEION-09 meta-analysis	7
Correction to: Editorial: Cancer metastasis through the lymphovascular system: molecular mechanisms of cancer metastasis	6
CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells	6
Development and characterization of a rat brain metastatic tumor model by multiparametric magnetic resonance imaging and histomorphology	6

Interrogating the roles of lymph node metastasis in systemic immune surveillance	6
Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance	6
Application of CTC discoveries for liquid biopsy: the RPL/RPS gene signature of melanoma CTCs is linked to brain metastasis onset	6
Serum conversion pattern of SCC-Ag levels between pre- and post-chemoradiotherapy predicts recurrence and metastasis in cervical cancer: a multi-institutional analysis	6
Prospective assessment of AR splice variant and PSMA detection on circulating tumor cells of mCRPC patients: preliminary analysis of patients enrolled in PRIMERA trial (NCT04188275)	6
Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis	5
Role of CD44 isoforms in epithelial-mesenchymal plasticity and metastasis	5
Establishing patient-derived tumor organoids of bone metastasis from lung adenocarcinoma reveals the transcriptomic changes underlying denosumab treatment	5
Introduction: Novel Frontiers in Cancer Metastasis	5
Platycodin D represses β-catenin to suppress metastasis of cetuximab-treated KRAS wild-type colorectal cancer cells	5
SBRT for elderly oligometastatic patients as a feasible, safe and effective treatment opportunity	5
CD276 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma through the TGF-β/SMAD signaling	5
International cooperation to fight cancer’s late-stage presentation in low- and middle-income countries	5
Cancer cell metabolic plasticity in migration and metastasis	4
The role of epigenetic modifications in Colorectal Cancer Metastasis	4
Management of melanoma: can we use gene expression profiling to help guide treatment and surveillance?	4
Understanding the cell survival mechanism of anoikis-resistant cancer cells during different steps of metastasis	4
Intraperitoneal drug delivery systems releasing cytostatic agents to target gastro-intestinal peritoneal metastases in laboratory animals: a systematic review	4
CD44 in Bone Metastasis Development: A Key Player in the Fate Decisions of the Invading Cells?	4
Distinguishing pure histopathological growth patterns of colorectal liver metastases on CT using deep learning and radiomics: a pilot study	4
Collective metastasis: coordinating the multicellular voyage	4
Metastatic sites and clinical outcomes in renal cell carcinoma patients receiving immune-based combinations: the MOUSEION-08 study	4
Detecting and monitoring tumors in orthotopic colorectal liver metastatic animal models with high-resolution ultrasound	4
Membrane Lipid Replacement for reconstituting mitochondrial function and moderating cancer-related fatigue, pain and other symptoms while counteracting the adverse effects of cancer cytotoxic therapy	4
Clinical applications of circulating tumor cells in patients with solid tumors	3
Downregulation of LINC00886 facilitates epithelial–mesenchymal transition through SIRT7/ELF3/miR-144 pathway in esophageal squamous cell carcinoma	3
Intraperitoneal drug delivery systems releasing cytostatic agents to target gastro‐intestinal peritoneal metastases in laboratory animals: a systematic review	3
Correction: Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer	3
miR-106a-5p carried by tumor-derived extracellular vesicles promotes the invasion and metastasis of ovarian cancer by targeting KLF6	3
Efficacy and safety of thoracic radiotherapy for extensive stage small cell lung cancer after immunotherapy in real world	3
Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels	3
Current pharmacologic treatment of brain metastasis in non-small cell lung cancer	3
Cancer metastasis through the lymphatic versus blood vessels	3
A new Neu—a syngeneic model of spontaneously metastatic HER2-positive breast cancer	3
miRNAs in pancreatic cancer progression and metastasis	3
Review old bone, new tricks	3
Immunotherapy of cancer in the era of checkpoint inhibitor	3
Factors associated with the distribution of brain metastases in lung cancer: a retrospective study	3
Multi-marker analysis of circulating tumor cells in localized intermediate/high-risk and metastatic prostate cancer	3
Stereotactic body radiotherapy for spinal oligometastases: a survey on patterns of practice on behalf of the Italian Association of Clinical Oncology and Radiotherapy (AIRO)	3
Portal vein tumor thrombosis in hepatocellular carcinoma: molecular mechanism and therapy	3
Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancer	3
Associations amongst genes, molecules, cells, and organs in breast cancer metastasis	3
The lymphatic system and sentinel lymph nodes: conduit for cancer metastasis	3
The gastrointestinal microbiota in colorectal cancer cell migration and invasion	3
Neoadjuvant therapy for resectable melanoma	3