OOIR: Observatory of International Research

Papers

(The median citation count of Clinical & Experimental Metastasis is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Understanding the cell survival mechanism of anoikis-resistant cancer cells during different steps of metastasis	67
Cancer cell metabolic plasticity in migration and metastasis	57
Breast cancer liver metastasis: current and future treatment approaches	54
Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels	45
TGFβ signaling networks in ovarian cancer progression and plasticity	39
Molecular and cellular mechanisms controlling integrin-mediated cell adhesion and tumor progression in ovarian cancer metastasis: a review	33
Mechanisms of breast cancer metastasis	30
The lymphatic system and sentinel lymph nodes: conduit for cancer metastasis	29
CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells	29
Cancer neoantigens as potential targets for immunotherapy	28
Collective metastasis: coordinating the multicellular voyage	27
Distinguishing pure histopathological growth patterns of colorectal liver metastases on CT using deep learning and radiomics: a pilot study	27
Correlation of exosomal microRNA clusters with bone metastasis in non-small cell lung cancer	26
Role of CD44 isoforms in epithelial-mesenchymal plasticity and metastasis	26
Type IV collagen as a potential biomarker of metastatic breast cancer	24
Cancer heterogeneity and metastasis: life at the edge	23
Breast cancer disparities in outcomes; unmasking biological determinants associated with racial and genetic diversity	22
The role of stereotactic body radiation therapy and its integration with systemic therapies in metastatic kidney cancer: a multicenter study on behalf of the AIRO (Italian Association of Radiotherapy	18
EMT-independent detection of circulating tumor cells in human blood samples and pre-clinical mouse models of metastasis	18
Wnt/β-catenin/Slug pathway contributes to tumor invasion and lymph node metastasis in head and neck squamous cell carcinoma	18
Impact of the COVID-19 pandemic on quality of life and emotional wellbeing in patients with bone metastases treated with radiotherapy: a prospective cohort study	18
Electrochemotherapy of skin metastases from breast cancer: a systematic review	17
Current challenges in metastasis research and future innovation for clinical translation	16
The gastrointestinal microbiota in colorectal cancer cell migration and invasion	16
The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo	15

Downregulation of LINC00886 facilitates epithelial–mesenchymal transition through SIRT7/ELF3/miR-144 pathway in esophageal squamous cell carcinoma	15
Comparative associations of baseline frailty status and age with postoperative mortality and duration of hospital stay following metastatic brain tumor resection	14
Stereotactic body radiation therapy for adrenal gland metastases: outcome and predictive factors from a multicenter analysis	14
Stereotactic body radiotherapy to lymph nodes in oligoprogressive castration-resistant prostate cancer patients: a post hoc analysis from two phase I clinical trials	14
Secondary lymphedema from cancer therapy	14
Detection of melanoma, breast cancer and head and neck squamous cell cancer sentinel lymph nodes by Tc-99m Tilmanocept (Lymphoseek®)	14
Interconnected high-dimensional landscapes of epithelial–mesenchymal plasticity and stemness in cancer	13
Oligoprogressive castration-resistant prostate cancer treated with metastases-directed stereotactic body radiation therapy: predictive factors for patients’ selection	12
miR-106a-5p carried by tumor-derived extracellular vesicles promotes the invasion and metastasis of ovarian cancer by targeting KLF6	12
Detection of cancer metastasis: past, present and future	12
The role of sentinel lymph node mapping in colon cancer: detection of micro-metastasis, effect on survival, and driver of a paradigm shift in extent of colon resection	12
Hypofractionated frameless gamma knife radiosurgery for large metastatic brain tumors	11
Survival outcome and prognostic factors for colorectal cancer with synchronous bone metastasis: a population-based study	11
Sentinel lymph node biopsy in melanoma: beyond histologic factors	11
Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling	11
Stereotactic body radiotherapy (SBRT) and concomitant systemic therapy in oligoprogressive breast cancer patients	11
FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells	10
Defining the landscape of metabolic dysregulations in cancer metastasis	10
Cancer microenvironment and genomics: evolution in process	10
Cells in the polyaneuploid cancer cell (PACC) state have increased metastatic potential	10
Metastasis prevention: targeting causes and roots	10
Precision oncology for breast cancer through clinical trials	10
Emerging photoacoustic and thermoacoustic imaging technologies for detecting primary and metastatic cancer and guiding therapy	10
The role of intraperitoneal chemotherapy in the surgical management of pancreatic ductal adenocarcinoma: a systematic review	10
Anti-invasive effects of minoxidil on human breast cancer cells: combination with ranolazine	10
Arresting metastasis within the microcirculation	10
Long non-coding RNA NRSN2-AS1, transcribed by SOX2, promotes progression of esophageal squamous cell carcinoma by regulating the ubiquitin-degradation of PGK1	9
Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer	9
Portal vein tumor thrombosis in hepatocellular carcinoma: molecular mechanism and therapy	9
Sufentanil combined with parecoxib sodium inhibits proliferation and metastasis of HER2-positive breast cancer cells and regulates epithelial-mesenchymal transition	9
In-transit metastatic cutaneous melanoma: current management and future directions	9
Current management of melanoma patients with nodal metastases	8
Travelling under pressure - hypoxia and shear stress in the metastatic journey	8
SBRT for elderly oligometastatic patients as a feasible, safe and effective treatment opportunity	8
Serum conversion pattern of SCC-Ag levels between pre- and post-chemoradiotherapy predicts recurrence and metastasis in cervical cancer: a multi-institutional analysis	8
Longitudinal CTCs gene expression analysis on metastatic castration-resistant prostate cancer patients treated with docetaxel reveals new potential prognosis markers	8
Cardiooncology—dealing with modern drug treatment, long-term complications, and cancer survivorship	8
Characterizing perfusion defects in metastatic lymph nodes at an early stage using high-frequency ultrasound and micro-CT imaging	8
Exosomal EphA2 promotes tumor metastasis of triple-negative breast cancer by damaging endothelial barrier	8
Risk factors for surgical site infection and association of surgical site infection with survival of lower rectal cancer patients without clinical lateral pelvic lymph node metastasis (clinical Stage	8
Molecular prognostic indicators in HPV-positive oropharyngeal cancer: an updated review	8
Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver	7
miRNAs in pancreatic cancer progression and metastasis	7
Electrochemotherapy of skin metastases from malignant melanoma: a PRISMA-compliant systematic review	7
The transcribed ultraconserved element uc.51 promotes the proliferation and metastasis of breast cancer by stabilizing NONO	7
Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems	7
The role of epigenetic modifications in Colorectal Cancer Metastasis	7
Resistance to targeted therapies in acute myeloid leukemia	7
Identification of miR-4510 as a metastasis suppressor of gastric cancer through regulation of tumor microenvironment via targeting GPC3	7
Prostate cancer addiction to oxidative stress defines sensitivity to anti-tumor neutrophils	7

Gemcitabine induces polarization of mouse peritoneal macrophages towards M1-like and confers antitumor property by inducing ROS production	6
Histopathological growth patterns of resected non-colorectal, non-neuroendocrine liver metastases: a retrospective multicenter study	6
Stereotactic radiotherapy of nodal oligometastases from prostate cancer: a prisma-compliant systematic review	6
Molecular insights into the interplay between adiposity, breast cancer and bone metastasis	6
JUNB suppresses distant metastasis by influencing the initial metastatic stage	6
The effect of the low stromal ratio induced by neoadjuvant chemotherapy on recurrence patterns in borderline resectable pancreatic ductal adenocarcinoma	6
Myeloid derived suppressor cells and the release of micro-metastases from dormancy	6
Extensive diagnostic work-up for patients with carcinoma of unknown primary	6
Systematic review of stereotactic body radiotherapy for nodal metastases	6
Protective measures for patients with advanced cancer during the Sars-CoV-2 pandemic: Quo vadis?	6
Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models	6
Empowering study of breast cancer data with application of artificial intelligence technology: promises, challenges, and use cases	6
Synchronous peritoneal metastases from lung cancer: incidence, associated factors, treatment and survival: a Dutch population-based study	6
Transcription factor c-Myb: novel prognostic factor in osteosarcoma	5
Integrating stereotactic body radiation therapy (SBRT) and systemic treatments in oligoprogressive prostate cancer: new evidence from the literature	5
Early biochemical outcomes following PSMA guided approach for bIoCHEmical relapse after prostatectomy-PSICHE trial (NCT05022914): preliminary results	5
PSMA-guided metastases directed therapy for bone castration sensitive oligometastatic prostate cancer: a multi-institutional study	5
Intraperitoneal drug delivery systems releasing cytostatic agents to target gastro-intestinal peritoneal metastases in laboratory animals: a systematic review	5
PITX1 suppresses osteosarcoma metastasis through exosomal LINC00662-mediated M2 macrophage polarization	5
Clinical applications of circulating tumor cells in patients with solid tumors	5
Effect of liver metastasis on the efficacy of immune checkpoint inhibitors in cancer patients: a systemic review and meta-analysis	5
CD44 in Bone Metastasis Development: A Key Player in the Fate Decisions of the Invading Cells?	5
Inhibition of LPS-mediated TLR4 activation abrogates gastric adenocarcinoma-associated peritoneal metastasis	5
LITAF inhibits colorectal cancer stemness and metastatic behavior by regulating FOXO1-mediated SIRT1 expression	5
Improved detection of sentinel lymph node metastases allows reliable intraoperative identification of patients with extended axillary lymph node involvement in early breast cancer	4
Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics	4
Data mining of key genes expression in hepatocellular carcinoma: novel potential biomarkers of diagnosis prognosis or progression	4
The smac mimetic LCL161 targets established pulmonary osteosarcoma metastases in mice	4
PLXDC2 enhances invadopodium formation to promote invasion and metastasis of gastric cancer cells via interacting with PTP1B	4
Single‐fraction versus hypofractionated gamma knife radiosurgery for small metastatic brain tumors	4
Prospective assessment of AR splice variant and PSMA detection on circulating tumor cells of mCRPC patients: preliminary analysis of patients enrolled in PRIMERA trial (NCT04188275)	4
Fluid shear stress influences invasiveness of HeLa cells through the induction of autophagy	3
Better pain control with 8-gray single fraction palliative radiotherapy for skeletal metastases: a Bayesian network meta-analysis	3
Comparison of trastuzumab emtansine, trastuzumab deruxtecan, and disitamab vedotin in a multiresistant HER2-positive breast cancer lung metastasis model	3
Endobronchial ultrasound-guided transbronchial needle aspiration in peripheral pulmonary lesions: a systematic review and meta-analysis	3
Introduction: Novel Frontiers in Cancer Metastasis	3
Efficacy and safety of thoracic radiotherapy for extensive stage small cell lung cancer after immunotherapy in real world	3
Review old bone, new tricks	3
Belvarafenib penetrates the BBB and shows potent antitumor activity in a murine melanoma brain metastasis model	3
Perfusion defects in non-enlarged metastatic lymph nodes using vessel wall magnetic resonance imaging: Detection performance and diagnostic value	3
Treating colorectal peritoneal metastases with an injectable cytostatic loaded supramolecular hydrogel in a rodent animal model	3
‘Sandwich treatment’ for posterior fossa brain metastases with volume larger than 4cm3: a multicentric retrospective study	3
PIM3 kinase promotes tumor metastasis in hepatoblastoma by upregulating cell surface expression of chemokine receptor cxcr4	3
Current status of gastrointestinal tract cancer brain metastasis and the use of blood-based cancer biomarker biopsy	3
Development and adaptations of the Graded Prognostic Assessment (GPA) scale: a systematic review	3
Antigen presenting cells in cancer immunity and mediation of immune checkpoint blockade	3
Computational markers for personalized prediction of outcomes in non-small cell lung cancer patients with brain metastases	3
ADC textural features in patients with single brain metastases improve clinical risk models	3
Innovations in radiotherapy and advances in immunotherapy for the treatment of brain metastases	3
Immunotherapy of cancer in the era of checkpoint inhibitor	3
PET/CT in assessment of colorectal liver metastases: a comprehensive review with emphasis on 18F-FDG	2
Nanoparticles loaded with circ_0086375 for suppressing the tumorigenesis of pancreatic cancer by targeting the miR-646/SLC4A4 axis	2
Electron beam intraoperative radiotherapy for metastatic epidural spinal cord compression: a prospective observational study	2
Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker	2
Clinical characteristics, treatment, and long-term outcome of patients with brain metastases from thyroid cancer	2
Introduction to novel developments in radio-imaging and radiotherapy	2
Establishment and Image based evaluation of a New Preclinical Rat Model of Osteoblastic Bone Metastases	2
Development and characterization of a rat brain metastatic tumor model by multiparametric magnetic resonance imaging and histomorphology	2
Clinical relevance of biomarker discordance between primary breast cancers and synchronous axillary lymph node metastases	2
A case of lung and mediastinal and hilar lymph node metastasis in a patient with cancer of unknown primary site	2
Repurposing fluphenazine to suppress melanoma brain, lung and bone metastasis by inducing G0/G1 cell cycle arrest and apoptosis and disrupting autophagic flux	2
International cooperation to fight cancer’s late-stage presentation in low- and middle-income countries	2
Modeling breast cancer survival and metastasis rates from moderate-sized clinical data	2
Donald L. Morton Memorial Lecture: the legacy of Donald Morton: past, present and future	2
Associations amongst genes, molecules, cells, and organs in breast cancer metastasis	2
Putative anoikis resistant subpopulations are enriched in lymph node metastases and indicate adverse prognosis in colorectal carcinoma	2
Comparison of ex vivo bioluminescence imaging, Alu-qPCR and histology for the quantification of spontaneous lung and bone metastases in subcutaneous xenograft mouse models	2
External validation of a red cell-based blood prognostic score in patients with metastatic renal cell carcinoma treated with first-line immunotherapy combinations	2
High sensitivity flow cytometry immunophenotyping increases the diagnostic yield of malignant pleural effusions	2