EMBO Journal

Article	Citations
Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis	1028
High‐resolution mapping of function and protein binding in an RNA nuclear enrichment sequence	471
Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer	298
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	281
PKM2‐TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability	171
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase	170
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	164
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	157
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	153
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis	142
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	128
The plant noncoding transcriptome: a versatile environmental sensor	125
Nascent polypeptide within the exit tunnel stabilizes the ribosome to counteract risky translation	120
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	120
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	103
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	97
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	97
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization	96
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	96
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks	94
Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane	93
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	93
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	92
Torsin and NEP1R1‐CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid‐dependent and lipid‐independent mechanisms	91
Presynaptic targeting of botulinum neurotoxin type A requires a tripartitePSG‐Syt1‐SV2plasma membrane nanocluster for synaptic vesicle entry	89

Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools	88
In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	87
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research	86
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	85
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	82
CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system	74
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	73
Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration	72
High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane	72
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	72
Eating your mitochondria—when too much of a good thing turns bad	70
ZZ domains keep cytosol to vacuole delivery whiZZing along	69
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity	68
PRMT1 promotes the tumor suppressor function of p14 ARF and is indicative for pancreatic cancer prognosis	68
The Hippo pathway drives the cellular response to hydrostatic pressure	68
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	67
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	66
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion	65
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	64
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break formation	64
Evolutionary adaptation of the protein folding pathway for secretability	64
CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma	63
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	62
Sir3 heterochromatin protein promotes non‐homologous end joining by direct inhibition of Sae2	61
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	58
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori	58
ArfGAP1 inhibits mTORC1 lysosomal localization and activation	57
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	55
Regulated splicing of large exons is linked to phase‐separation of vertebrate transcription factors	53
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation	53
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression	53
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	53
Dynamic EMT: a multi‐tool for tumor progression	53
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	53
Interferon‐inducible phospholipids govern IFITM3‐dependent endosomal antiviral immunity	52
The glycine arginine‐rich domain of the RNA‐binding protein nucleolin regulates its subcellular localization	52
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	52
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking GTPase activity	52
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	51
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	51
Ribosome biogenesis factors—from names to functions	51
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	50
Autophagy power expands: fuse those cells!	50
Restraining CDK1–cyclin B activation: PP2A on the cUSP(7)	50
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	50
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	50
NPC1 regulates the distribution of phosphatidylinositol 4‐kinases at Golgi and lysosomal membranes	49
Dual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins	49
Expression of human‐specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility	49
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	48

LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function	48
Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans	48
Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis	48
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	47
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3‐mediated plant senescence pathway	47
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	47
DRP1 interacts directly with BAX to induce its activation and apoptosis	47
The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80	46
Living a longer life: unique lessons from the naked mole‐rat blood system	46
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response	46
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	46
Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation	46
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	45
DNA asymmetry promotes SUMO modification of the single‐stranded DNA‐binding protein RPA	44
c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells	44
Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop	44
Structure and mechanism of a eukaryotic ceramide synthase complex	43
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	43
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus	43
Microglial MERTK eliminates phosphatidylserine‐displaying inhibitory post‐synapses	43
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	43
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	42
Cancer evolution: Darwin and beyond	42
Subcellular localization of Type VI secretion system assembly in response to cell–cell contact	42
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	42
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	42
Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila	42
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	42
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis PR gene expression and disease resistance	41
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	41
Quorum sensing governs collective dendritic cell activation in vivo	41
Stress‐dependent macromolecular crowding in the mitochondrial matrix	41
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	39
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	39
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	39
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation	38
Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch	38
Protein synthesis control in cancer: selectivity and therapeutic targeting	38
Seeing eye to eye: photoreceptors employ nanotube‐like connections for material transfer	38
C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation	38
The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation	37
The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast	37
LUBAC and NF‐κB trigger a nuclear response from mitochondria	37
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	37
Reply to “An alternative miRISC targets a cancer‐associated coding sequence mutation in FOXL2”	37
R‐spondin signaling in the stomach: isthmal Lgr4 rules	37
Widespread displacement of DNA‐ and RNA‐binding factors underlies toxicity of arginine‐rich cell‐penetrating peptides	36
The needs of a synapse—How local organelles serve synaptic proteostasis	36
Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance	36
Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes	36
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	36
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	36
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	36
Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway	36
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	36
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6‐methyladenosine‐containing RNA virus	35
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	35
TFEB‐dependent lysosome biogenesis is required for senescence	35
Multi‐modal adaptor‐clathrin contacts drive coated vesicle assembly	35
Nix interacts with WIPI2 to induce mitophagy	35
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	35
Transport unplugged: KCCs are regulated through an N‐terminal plug of the ion pathway	35
Stem cells “aclymatise” to regenerate the blood system	34
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	34
E‐cadherin mediates apical membrane initiation site localisation duringde novopolarisation of epithelial cavities	34
The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis	34
Too much death can kill you: inhibiting intrinsic apoptosis to treat disease	34
A CRMP4‐dependent retrograde axon‐to‐soma death signal in amyotrophic lateral sclerosis	33
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	33
Binary organization of epidermal basal domains highlights robustness to environmental exposure	33
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	33
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	33
A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cells	33
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint	33
ER‐anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6	33
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	32
Mammalian antiviral RNAi is on the move	32
PABP prevents the untimely decay of select mRNA populations in human cells	32
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila	32
The CRL4 DCAF1 cullin‐RING ubiquitin ligase is activated following a switch in oligomerization state	32

The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	32
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	32
Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells	32
Mitochondria and peroxisomes are NIXed for clearance	32
Keep the fate: how chromatin regulators safeguard embryonic stem cell identity	32
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange	31
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	31
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	31
Deciphering functional tumor states at single‐cell resolution	31
Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration	30
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	30
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	30
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading	30
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	30
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	30
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	30
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	30
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	29
BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis	29
Hold the fold: how delayed folding aids protein secretion	29
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	29
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin	29
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis	29
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	29
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion	29
A sudden collapse: the disaggregation of amyloid fibres	29
Some viruses need to phase‐separate to replicate	28
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	28
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	28
Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	28
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	28
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α	28
Quorum sensing componentry opens new lines of communication	28
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	28
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	27
Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease	27
The TOR‐dependent phosphoproteome and regulation of cellular protein synthesis	27
Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology	27
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication	27
Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol	27
Piwi–piRNA complexes induce stepwise changes in nuclear architecture at target loci	27
Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines	27
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response	27