OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Journal is 37. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	189
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	175
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	175
The plant noncoding transcriptome: a versatile environmental sensor	156
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	127
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	122
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	120
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	117
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	116
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	115
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	113
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	112
In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	110
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	98
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	97
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	94
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	92
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1‐SV2 plasma membrane nanocluster for synaptic vesicle entry	92
Evolutionary adaptation of the protein folding pathway for secretability	88
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori	87
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	86
Eating your mitochondria—when too much of a good thing turns bad	86
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	83
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking GTPase activity	82
Interferon‐inducible phospholipids govern IFITM3‐dependent endosomal antiviral immunity	80

Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break formation	80
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation	79
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	78
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	78
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	78
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	76
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression	75
Ribosome biogenesis factors—from names to functions	74
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	72
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	71
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	70
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	70
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	69
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	69
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3‐mediated plant senescence pathway	66
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	66
The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80	65
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	64
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	64
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	63
Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila	63
Erratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	63
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	62
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	62
Structure and mechanism of a eukaryotic ceramide synthase complex	61
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	61
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	61
Stress‐dependent macromolecular crowding in the mitochondrial matrix	61
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	58
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	57
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	55
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	55
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis PR gene expression and disease resistance	54
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	54
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	53
LUBAC and NF‐κB trigger a nuclear response from mitochondria	52
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	52
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	51
Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance	51
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	50
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6‐methyladenosine‐containing RNA virus	50
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	50
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	49
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	49
Nix interacts with WIPI2 to induce mitophagy	49
TFEB‐dependent lysosome biogenesis is required for senescence	49
Binary organization of epidermal basal domains highlights robustness to environmental exposure	48
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	48
A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cells	48
E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities	47

Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	46
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	46
Mitochondria and peroxisomes are NIXed for clearance	45
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	45
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	45
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	45
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	43
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	42
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	42
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion	42
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	42
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	42
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	42
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	42
Hold the fold: how delayed folding aids protein secretion	41
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	41
Quorum sensing componentry opens new lines of communication	41
Erratum To: Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	41
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α	40
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	40
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	40
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication	39
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	38
Two Hippo signaling modules orchestrate liver size and tumorigenesis	38
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	38
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding	38
STAT1 is required to establish but not maintain interferon‐γ‐induced transcriptional memory	37
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases	37
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	37
Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies	37
Erratum To: Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	37
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	37
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion	37
Fuel oxidation under the control of mitochondrial shape and dynamics	37
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation	37