OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Journal is 36. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	218
PGE ₂ ‐EP3 axis promotes brown adipose tissue formation through stabil	204
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and	174
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB	160
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4 ⁺	155
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK	140
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	113
The plant noncoding transcriptome: a versatile environmental sensor	113
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR	109
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	108
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	104
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	101
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	101
TDAG51 promotes transcription factor FoxO1 activity during LPS ‐ind	101
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma m	98
IDH2 stabilizes HIF ‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	96
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	92
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	88
In vivo reduction of RAD51 ‐mediated homologous recombination triggers aging but impairs oncogenesis	87
The SMC5 /6 complex recruits the PAF1 complex to facilitate DNA	86
Eating your mitochondria—when too much of a good thing turns bad	83
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC	83
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	83
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break format	82
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	81

A network of small RNAs regulates sporulation initiation in Clostridioides difficile	78
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking	76
Interferon‐inducible phospholipids govern IFITM3 ‐dependent endosomal antiviral immunity	75
The Hippo pathway drives the cellular response to hydrostatic pressure	73
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	73
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	72
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in	72
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	69
MARCH5 ‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7	69
Ribosome biogenesis factors—from names to functions	69
Evolutionary adaptation of the protein folding pathway for secretability	66
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	65
Strigolactones promote plant freezing tolerance by releasing the WRKY41 ‐mediated inhibition of CB	65
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	65
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	65
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	64
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	63
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	63
Autophagy power expands: fuse those cells!	62
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	61
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	59
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	58
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	58
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3 ‐mediated plant senescence pathway	57
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	57
Stress‐dependent macromolecular crowding in the mitochondrial matrix	56
The CTLA ‐4 immune checkpoint protein regulates PD‐L1 : PD	56
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	56
Structure and mechanism of a eukaryotic ceramide synthase complex	56
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	55
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	54
Subcellular localization of Type VI secretion system assembly in response to cell–cell contact	52
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	52
Living a longer life: unique lessons from the naked mole‐rat blood system	52
Evidence for existence of an apoptosis‐inducing BH3 ‐only protein, sayonara , in <	51
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	51
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	51
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	50
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	49
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis<	49
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	49
LUBAC and NF‐κB trigger a nuclear response from mitochondria	48
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	48
R‐spondin signaling in the stomach: isthmal Lgr4 rules	48
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	48
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	48
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	47
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6	46
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	46
Nix interacts with WIPI2 to induce mitophagy	46

Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	45
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	45
CRIP1 suppresses BBOX1 ‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	45
TFEB ‐dependent lysosome biogenesis is required for senescence	44
Extra centrosomes induce PIDD1 ‐mediated inflammation and immunosurveillance	44
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	43
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	43
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	43
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	42
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	42
E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities	42
A critical period of prehearing spontaneous Ca ²⁺ spiking is required for hair‐bundle maintenance in inner hair cells	42
Binary organization of epidermal basal domains highlights robustness to environmental exposure	42
Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration	41
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	41
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	41
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	41
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	41
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	40
Mitochondria and peroxisomes are NIXed for clearance	40
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	39
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	39
NALCN ‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	39
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	39
SHP ‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	39
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	38
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhanci	38
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	38
Quorum sensing componentry opens new lines of communication	37
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	37
Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	37
A sudden collapse: the disaggregation of amyloid fibres	37
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	37
Hold the fold: how delayed folding aids protein secretion	37
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	37
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HI	37
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	36
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	36
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation	36
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases	36
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	36
Two Hippo signaling modules orchestrate liver size and tumorigenesis	36
Disulfiram bolsters T‐cell anti‐tumor immunity through direct activation of LCK‐mediated TCR signaling	36
STAT1 is required to establish but not maintain interferon‐γ‐induced transcriptional memory	36
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA ‐mediated mitochondrial–nuclear communication	36
Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	36
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion	36
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	36