EMBO Journal

Papers
(The TQCC of EMBO Journal is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
Autophagy in major human diseases545
Molecular mechanisms and physiological functions of mitophagy504
SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells492
SARS ‐CoV‐2 targets neurons of 3D human brain organoids374
Syncytia formation by SARS‐CoV‐2‐infected cells337
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells313
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2294
m 6 A RNA methylation: from mechanisms to therapeutic potential284
Dynamic EMT: a multi‐tool for tumor progression250
RNA m 6 A methylation regulates sorafenib resistance in liver cancer through FOXO 3‐mediated autophagy241
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells213
m 6 A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy206
Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer199
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia198
Cholesterol 25‐Hydroxylase inhibits SARS ‐CoV‐2 and other coronaviruses by depleting membrane cholesterol195
SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs182
Structures of the SARS ‐CoV‐2 nucleocapsid and their perspectives for drug design174
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast151
Opposing activities of IFITM proteins in SARS‐CoV‐2 infection148
An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells143
Cell death pathways: intricate connections and disease implications132
SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation129
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation126
MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation116
LRRK 2 activation controls the repair of damaged endomembranes in macrophages111
Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage110
Cancer evolution: Darwin and beyond106
A novel approach to measure mitochondrial respiration in frozen biological samples105
Loss of salt tolerance during tomato domestication conferred by variation in a Na + /K + transporter104
Pore formation in regulated cell death103
Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions99
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction99
ATP and cancer immunosurveillance99
Temporal specificity and heterogeneity of Drosophila immune cells95
Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP91
On the role of phase separation in the biogenesis of membraneless compartments91
Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress90
CARD8 inflammasome activation triggers pyroptosis in human T cells90
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding90
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner89
The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants88
CALCOCO 1 acts with VAMP ‐associated proteins to mediate ER ‐phagy82
ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways79
Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b75
SCHENGEN receptor module drives localized ROS production and lignification in plant roots74
Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy73
Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment73
Ca 2+ signals in plant immunity73
BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis72
Translation of small downstream ORFs enhances translation of canonical main open reading frames72
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition72
A guide to naming human non‐coding RNA genes70
ATMCHK 2‐Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress69
SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage69
FFAT motif phosphorylation controls formation and lipid transfer function of inter‐organelle contacts68
Mechanisms of site‐specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits68
Cell softness regulates tumorigenicity and stemness of cancer cells67
Sealing holes in cellular membranes67
Highly active rubiscos discovered by systematic interrogation of natural sequence diversity66
Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi‐enzyme complexes in Escherichia coli66
Stable expansion of high‐grade serous ovarian cancer organoids requires a low‐Wnt environment65
Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies64
Clock component OsPRR73 positively regulates rice salt tolerance by modulating OsHKT2;1 ‐mediated sodium homeostasis64
The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking62
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation61
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses61
Flavonol‐mediated stabilization of PIN efflux complexes regulates polar auxin transport59
BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡59
Local rewiring of genome–nuclear lamina interactions by transcription58
Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress58
Fungal‐induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL‐2258
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis58
Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins57
Syncytia formation by SARS‐CoV‐2‐infected cells57
Glutamine deprivation alters the origin and function of cancer cell exosomes56
DRP1 interacts directly with BAX to induce its activation and apoptosis55
MiT/ TFE factors control ER ‐phagy via transcriptional regulation of FAM 134B55
LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes54
Best practices for the visualization, mapping, and manipulation of R‐loops54
Peering into tunneling nanotubes—The path forward54
Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila54
The multi‐scale architecture of mammalian sperm flagella and implications for ciliary motility54
Modulation of plant root growth by nitrogen source‐defined regulation of polar auxin transport53
Axonal precursor mi RNA s hitchhike on endosomes and locally regulate the development of neural circuits53
Plant immunity suppression via PHR1‐RALF‐FERONIA shapes the root microbiome to alleviate phosphate starvation52
Roles of plant retinoblastoma protein: cell cycle and beyond52
Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70‐mediated trimer unzipping and dissociation from DNA52
Structure of a human replisome shows the organisation and interactions of a DNA replication machine52
Neurexins cluster Ca 2+ channels within the presynaptic active zone52
The multifaceted role of autophagy in cancer51
Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes51
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling51
A plant‐specific SWR1 chromatin‐remodeling complex couples histone H2A.Z deposition with nucleosome sliding51
Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B51
Tollip coordinates Parkin‐dependent trafficking of mitochondrial‐derived vesicles50
SKIPHOPS recruits TBC 1D15 for a Rab7‐to‐Arl8b identity switch to control late endosome transport50
Paraspeckles are constructed as block copolymer micelles50
Grad‐seq in a Gram‐positive bacterium reveals exonucleolytic sRNA activation in competence control50
The extracellular vesicle generation paradox: a bacterial point of view49
Arabidopsis shoot stem cells display dynamic transcription and DNA methylation patterns49
Disrupting HIV ‐1 capsid formation causes cGAS sensing of viral DNA49
Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease49
NAADP ‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca 2+ nanodomains, calcineurin and dynamin49
Cell‐to‐cell transmission of C9orf72 poly‐(Gly‐Ala) triggers key features of ALS / FTD49
Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis48
The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species48
Nox4 regulates InsP 3 receptor‐dependent Ca 2+ release into mitochondria to promote cell survival47
Timeless couples G‐quadruplex detection with processing by DDX 11 helicase during DNA replication47
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration47
Structural insights into actin filament recognition by commonly used cellular actin markers47
An optimized quantitative proteomics method establishes the cell type‐resolved mouse brain secretome46
The cold response regulator CBF1 promotes Arabidopsis hypocotyl growth at ambient temperatures46
CompromisedDNArepair is responsible for diabetes‐associated fibrosis46
PIF1 helicase promotes break‐induced replication in mammalian cells46
Cyclin B1 scaffolds MAD 1 at the kinetochore corona to activate the mitotic checkpoint45
Cell competition in intratumoral and tumor microenvironment interactions45
HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations44
Structural basis of Focal Adhesion Kinase activation on lipid membranes44
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection43
Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF43
NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients43
HOIL‐1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation43
CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawal43
Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans42
Clustering and reverse transcription of HIV‐1 genomes in nuclear niches of macrophages42
Identification and characterization of diverse OTU deubiquitinases in bacteria42
Deciphering the regulatory landscape of fetal and adult γδ T‐cell development at single‐cell resolution41
HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer41
Golgi maturation‐dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH341
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity41
MSH 2 shapes the meiotic crossover landscape in relation to interhomolog polymorphism in Arabidopsis41
Long‐term expansion with germline potential of human primordial germ cell‐like cells in vitro41
5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING40
CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy40
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin40
Microglial MERTK eliminates phosphatidylserine‐displaying inhibitory post‐synapses40
A sensory cell diversifies its output by varying Ca 2+ influx‐release coupling among active zones40
Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction40
Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria40
Multilineage murine stem cells generate complex organoids to model distal lung development and disease40
BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites39
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress‐induced damaged mitochondrial DNA39
Microtubules control nuclear shape and gene expression during early stages of hematopoietic differentiation38
Plant E3 ligases SNIPER 1 and SNIPER 2 broadly regulate the homeostasis of sensor NLR immune re37
Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks37
Centrosome defects cause microcephaly by activating the 53BP1‐USP28‐TP53 mitotic surveillance pathway37
A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium37
Identification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sites37
Alterations of redox and iron metabolism accompany the development of HIV latency37
Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology36
Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation36
Osmostress enhances activating phosphorylation of Hog1 MAP kinase by mono‐phosphorylated Pbs2 MAP 2K36
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration36
Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants36
m 6 A modification of HSATIII lncRNAs regulates temperature‐dependent splicing36
A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐835
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks35
Non‐canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus35
A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus35
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells35
Activation of endogenous retroviruses during brain development causes an inflammatory response35
Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system35
Cryo‐EM structure of the CENP‐A nucleosome in complex with phosphorylated CENP‐C34
Single‐cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin‐driven circadian network34
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair34
Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis34
Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy34
ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation34
Expression of human‐specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility34
Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells34
SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice34
Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD2634
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency33
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response33
Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV‐1 infection33
Rewired signaling network in T cells expressing the chimeric antigen receptor ( CAR )33
RNA localization and co‐translational interactions control RAB 13 GTP ase function and cell migration33
A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes32
Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.232
Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway32
Nuclear cGAS: guard or prisoner?32
Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation32
Cellular stress promotes NOD1/2‐dependent inflammation via the endogenous metabolite sphingosine‐1‐phosphate32
Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit32
Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling31
Protein structure, amino acid composition and sequence determine proteome vulnerability to oxidation‐induced damage31
Structural insights into mammalian mitochondrial translation elongation catalyzed by mt EFG 131
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component31
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange31
Munc13 activates the Munc18‐1/syntaxin‐1 complex and enables Munc18‐1 to prime SNARE assembly31
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation31
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis31
Selective cross‐linking of coinciding protein assemblies by in‐gel cross‐linking mass spectrometry30
Regulation of mitochondrial proteostasis by the proton gradient30
Architecture of the centriole cartwheel‐containing region revealed by cryo‐electron tomography30
SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation30
Self‐assembly of multi‐component mitochondrial nucleoids via phase separation30
BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis30
Transcriptional repression of NFKBIA triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence30
EGFR ‐mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions30
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models30
LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy30
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome30
Dysfunctional oxidative phosphorylation shunts branched‐chain amino acid catabolism onto lipogenesis in skeletal muscle30
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr130
Structural basis for loading and inhibition of a bacterial T6 SS phospholipase effector by the VgrG spike30
Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features30
Open conformation of tetraspanins shapes interaction partner networks on cell membranes29
Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration29
Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates29
Adjustment of the PIF7‐HFR1 transcriptional module activity controls plant shade adaptation29
Unraveling the features of somatic transposition in the Drosophila intestine29
Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway29
A comparative analysis of the mobility of 45 proteins in the synaptic bouton29
ADP‐ribosylation of histone variant H2AX promotes base excision repair29
Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding28
N 6 ‐methyladenosine modification of lncRNA Pvt1 governs epidermal stemness28
Reproducible image handling and analysis28
Photoreceptor nanotubes mediate the in vivo exchange of intracellular material28
Structural basis for centromere maintenance by Drosophila CENP ‐A chaperone CAL 128
Light‐responsive microRNA miR‐211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance28
Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues28
A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies28
Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency28
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity28
RNF 43 truncations trap CK 1 to drive niche‐independent self‐renewal in cancer28
HASTY , the Arabidopsis EXPORTIN5 ortholog, regulates cell‐to‐cell and vascular microRNA movement28
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification28
Polarized sorting of Patched enables cytoneme‐mediated Hedgehog reception in the Drosophila wing disc27
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis27
m 6 A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region27
Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress27
Human shelterin protein POT 1 prevents severe telomere instability induced by homology‐directed DNA repair27
N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation27
Extracellular vesicles and particles impact the systemic landscape of cancer26
Metabolic switch and epithelial–mesenchymal transition cooperate to regulate pluripotency26
Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis26
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA26
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools26
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens26
Cryo‐EM structure of native human uromodulin, a zona pellucida module polymer26
Architecture of the active post‐translational Sec translocon26
RNA is required for the integrity of multiple nuclear and cytoplasmic membrane‐less RNP granules26
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration26
The structure of the MICU 1‐ MICU 2 complex unveils the regulation of the mitochondrial calcium uniporter25
Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab125
SEUSS integrates transcriptional and epigenetic control of root stem cell organizer specification25
Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency25
A genetic memory initiates the epigenetic loop necessary to preserve centromere position25
Helical ordering of envelope‐associated proteins and glycoproteins in respiratory syncytial virus25
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