EMBO Journal

Article	Citations
Autophagy in major human diseases	794
Molecular mechanisms and physiological functions of mitophagy	709
m 6 A RNA methylation: from mechanisms to therapeutic potential	394
Dynamic EMT: a multi‐tool for tumor progression	385
Syncytia formation by SARS‐CoV‐2‐infected cells	378
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells	246
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast	224
SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs	215
Cell death pathways: intricate connections and disease implications	183
Opposing activities of IFITM proteins in SARS‐CoV‐2 infection	168
An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells	158
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation	151
SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation	151
Cancer evolution: Darwin and beyond	141
ATP and cancer immunosurveillance	131
Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage	129
On the role of phase separation in the biogenesis of membraneless compartments	124
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner	124
The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants	113
Ca 2+ signals in plant immunity	108
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition	107
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation	94
The multifaceted role of autophagy in cancer	94
Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b	92
BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis	92

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy	86
Peering into tunneling nanotubes—The path forward	85
Sealing holes in cellular membranes	83
Cell softness regulates tumorigenicity and stemness of cancer cells	82
Clock component OsPRR73 positively regulates rice salt tolerance by modulating OsHKT2;1 ‐mediated sodium homeostasis	82
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses	78
SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage	78
The extracellular vesicle generation paradox: a bacterial point of view	76
Structure of a human replisome shows the organisation and interactions of a DNA replication machine	76
Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies	76
DRP1 interacts directly with BAX to induce its activation and apoptosis	75
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	75
Fungal‐induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL‐22	74
Plant immunity suppression via PHR1‐RALF‐FERONIA shapes the root microbiome to alleviate phosphate starvation	74
HOIL‐1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation	73
BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡	72
Flavonol‐mediated stabilization of PIN efflux complexes regulates polar auxin transport	69
Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease	68
Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila	66
Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis	65
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair	64
The multi‐scale architecture of mammalian sperm flagella and implications for ciliary motility	64
Modulation of plant root growth by nitrogen source‐defined regulation of polar auxin transport	64
Paraspeckles are constructed as block copolymer micelles	63
CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawal	62
PIF1 helicase promotes break‐induced replication in mammalian cells	62
Best practices for the visualization, mapping, and manipulation of R‐loops	61
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling	61
Syncytia formation by SARS‐CoV‐2‐infected cells	61
Clustering and reverse transcription of HIV‐1 genomes in nuclear niches of macrophages	61
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress‐induced damaged mitochondrial DNA	60
HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations	60
Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria	60
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection	59
Cell competition in intratumoral and tumor microenvironment interactions	58
Golgi maturation‐dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3	57
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration	56
Ribosome biogenesis factors—from names to functions	56
Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants	55
Microglial MERTK eliminates phosphatidylserine‐displaying inhibitory post‐synapses	55
Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology	54
Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF	54
Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis	53
Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans	52
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	52
5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING	50
Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl‐CoA	50
Single‐cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin‐driven circadian network	49
CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos	48
Identification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sites	48

Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity	48
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity	48
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin	48
A sensory cell diversifies its output by varying Ca 2+ influx‐release coupling among active zones	47
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr1	47
Extracellular vesicles and particles impact the systemic landscape of cancer	47
BNIP3L/NIX regulates both mitophagy and pexophagy	46
Protein synthesis control in cancer: selectivity and therapeutic targeting	46
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks	46
Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway	46
Expression of human‐specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility	46
Centrosome defects cause microcephaly by activating the 53BP1‐USP28‐TP53 mitotic surveillance pathway	46
BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis	46
Schwann cell precursors represent a neural crest‐like state with biased multipotency	45
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools	45
Activation of endogenous retroviruses during brain development causes an inflammatory response	44
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response	44
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration	44
ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation	44
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis	44
Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26	44
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens	44
Non‐canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus	43
Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks	43
Regulation of mitochondrial proteostasis by the proton gradient	43
LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy	43
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component	42
Self‐assembly of multi‐component mitochondrial nucleoids via phase separation	42
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency	41
A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes	41
Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features	41
A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease	41
m 6 A modification of HSATIII lncRNAs regulates temperature‐dependent splicing	41
Too much death can kill you: inhibiting intrinsic apoptosis to treat disease	40
Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV‐1 infection	40
Cellular stress promotes NOD1/2‐dependent inflammation via the endogenous metabolite sphingosine‐1‐phosphate	40
Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy	40
Nuclear cGAS: guard or prisoner?	40
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification	40
Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates	40
Transcriptional repression of NFKBIA triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence	39
Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system	38
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis	38
RNA is required for the integrity of multiple nuclear and cytoplasmic membrane‐less RNP granules	38
Endothelium‐derived lactate is required for pericyte function and blood–brain barrier maintenance	38
N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation	38
Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency	37
Photoreceptor nanotubes mediate the in vivo exchange of intracellular material	37
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation	37
A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies	37
Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit	37
Cryo‐EM structure of the CENP‐A nucleosome in complex with phosphorylated CENP‐C	36
ADP‐ribosylation of histone variant H2AX promotes base excision repair	36
Adjustment of the PIF7‐HFR1 transcriptional module activity controls plant shade adaptation	36
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange	36
m 6 A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region	36
HASTY , the Arabidopsis EXPORTIN5 ortholog, regulates cell‐to‐cell and vascular microRNA movement	36
RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency	35
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation	35
Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding	35
Reproducible image handling and analysis	35
Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis	35
Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress	35
Ageing induces tissue‐specific transcriptomic changes in Caenorhabditis elegans	34
ZDHHC18 negatively regulates cGAS‐mediated innate immunity through palmitoylation	34
Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex	34
USP8 promotes cancer progression and extracellular vesicle‐mediated CD8+ T cell exhaustion by deubiquitinating the TGF‐β receptor TβRII	34
The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type‐III effector	34
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	34
Selective cross‐linking of coinciding protein assemblies by in‐gel cross‐linking mass spectrometry	34
SNX10‐mediated LPS sensing causes intestinal barrier dysfunction via a caspase‐5‐dependent signaling cascade	34
Dermal αSMA + myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production	33
Cryo‐EM structure of native human uromodulin, a zona pellucida module polymer	33
Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis	33
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA	32
Barley stripe mosaic virus γb protein disrupts chloroplast antioxidant defenses to optimize viral replication	32
Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification	32
Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration	32
IFT54 directly interacts with kinesin‐II and IFT dynein to regulate anterograde intraflagellar transport	32
PKM2‐TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability	32

De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis	31
Pathogenic ACVR1R206H activation by Activin A‐induced receptor clustering and autophosphorylation	31
N 6 ‐methyladenosine modification of lncRNA Pvt1 governs epidermal stemness	31
Unraveling the features of somatic transposition in the Drosophila intestine	31
Deciphering functional tumor states at single‐cell resolution	31
Integrator is recruited to promoter‐proximally paused RNA Pol II to generate Caenorhabditis elegans piRNA precursors	31
Phytosulfokine peptide optimizes plant growth and defense via glutamine synthetase GS2 phosphorylation in tomato	30
m6A‐mediated alternative splicing coupled with nonsense‐mediated mRNA decay regulates SAM synthetase homeostasis	30
Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane	30
Histone chaperone CAF‐1 promotes HIV‐1 latency by leading the formation of phase‐separated suppressive nuclear bodies	30
Architecture of the active post‐translational Sec translocon	30
The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation	30
Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption	30
A stress‐induced tyrosine‐tRNA depletion response mediates codon‐based translational repression and growth suppression	30
GRASP55 regulates intra‐Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis	30
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	30
Helical ordering of envelope‐associated proteins and glycoproteins in respiratory syncytial virus	30
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	30
RNA‐based medicine: from molecular mechanisms to therapy	29
ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration	29
Tyr‐Asp inhibition of glyceraldehyde 3‐phosphate dehydrogenase affects plant redox metabolism	29
IFN‐β rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1	29
Torsin and NEP1R1‐CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid‐dependent and lipid‐independent mechanisms	29
Biochemically validated structural model of the 15‐subunit intraflagellar transport complex IFT‐B	29
Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex	29
The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains	29
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression	29
Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab1	29
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering‐induced Oma1 activation	29
Bacteria elicit a phage tolerance response subsequent to infection of their neighbors	29
PRMT1 promotes the tumor suppressor function of p14 ARF and is indicative for pancreatic cancer prognosis	29
Multiplexed CRISPR/CAS9‐mediated engineering of pre‐clinical mouse models bearing native human B cell receptors	29
Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression	29
MitoStores: chaperone‐controlled protein granules store mitochondrial precursors in the cytosol	28
The C‐degron pathway eliminates mislocalized proteins and products of deubiquitinating enzymes	28
The glycine arginine‐rich domain of the RNA‐binding protein nucleolin regulates its subcellular localization	28
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism‐like phenotype	28
Chromosomal instability by mutations in the novel minor spliceosome component CENATAC	28
Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress	28
Ontogeny and function of the circadian clock in intestinal organoids	28
Rabl2 GTP hydrolysis licenses BBSome‐mediated export to fine‐tune ciliary signaling	27
FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors	27
An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣membrane	27
Cancer‐associated POT1 mutations lead to telomere elongation without induction of a DNA damage response	27
TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis	27
Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates	27
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	27
Employing core regulatory circuits to define cell identity	27
Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4	27
Translational adaptation to heat stress is mediated by RNA 5‐methylcytosine in Caenorhabditis elegans	27
NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy	27
CircPVT1 promotes ER‐positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS	27
Ribosome slowdown triggers codon‐mediated mRNA decay independently of ribosome quality control	26
Gut microbiota regulates blood‐cerebrospinal fluid barrier function and Aβ pathology	26
Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation	26
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	26
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	26
Exon‐independent recruitment of SRSF1 is mediated by U1 snRNP stem‐loop 3	26
Acetylcholine‐synthesizing macrophages in subcutaneous fat are regulated by β 2 ‐adrenergic signaling	26
Prohibitin 1 regulates mtDNA release and downstream inflammatory responses	26
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	26
Structural basis of TRAPPIII‐mediated Rab1 activation	26
A switch from α‐helical to β‐strand conformation during co‐translational protein folding	26
Host autophagy mediates organ wasting and nutrient mobilization for tumor growth	26
Integrated requirement of non‐specific and sequence‐specific DNA binding in Myc‐driven transcription	26
Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome	25
Phospho‐regulation, nucleotide binding and ion access control in potassium‐chloride cotransporters	25
A new linear cyclin docking motif that mediates exclusively S‐phase CDK‐specific signaling	25
Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch	25
Regulation of autophagosome biogenesis by OFD1‐mediated selective autophagy	25
STING directly recruits WIPI2 for autophagosome formation during STING‐induced autophagy	25
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues	25
Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases	25
Oxidative stress protein Oxr1 promotes V‐ATPase holoenzyme disassembly in catalytic activity‐independent manner	25
Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates	25
1‐Undecene from Pseudomonas aeruginosa is an olfactory signal for flight‐or‐fight response in Caenorhabditis elegans	25
Dual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins	25
CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system	25
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	25
Translation‐coupled mRNA quality control mechanisms	25
The high‐energy transition state of the glutamate transporter homologue GltPh	25