EMBO Journal

Article	Citations
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	185
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	172
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	168
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	159
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	143
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	142
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	130
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	128
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis	125
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	122
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	113
The plant noncoding transcriptome: a versatile environmental sensor	112
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase	102
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization	101
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	99
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	94
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research	92
In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	91
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	90
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	89
CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system	88
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma m	88
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools	84
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	83
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking GTPase activity	83

A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	83
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	83
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	82
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	82
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion	82
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	80
The Hippo pathway drives the cellular response to hydrostatic pressure	77
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	71
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	70
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation	70
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity	69
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	69
Evolutionary adaptation of the protein folding pathway for secretability	69
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	68
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori	67
Interferon‐inducible phospholipids govern IFITM3‐dependent endosomal antiviral immunity	66
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	65
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break format	64
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression	63
Ribosome biogenesis factors—from names to functions	62
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	62
Eating your mitochondria—when too much of a good thing turns bad	62
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	61
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	61
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	59
Autophagy power expands: fuse those cells!	58
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	58
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	58
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	58
The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80	57
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3‐mediated plant senescence pathway	56
DRP1 interacts directly with BAX to induce its activation and apoptosis	55
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	55
LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function	55
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	54
Living a longer life: unique lessons from the naked mole‐rat blood system	54
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	54
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	53
Subcellular localization of Type VI secretion system assembly in response to cell–cell contact	52
Stress‐dependent macromolecular crowding in the mitochondrial matrix	52
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	51
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	51
Evidence for existence of an apoptosis‐inducing BH3 ‐only protein, sayonara , in <	51
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus	50
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	50
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	49
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	48
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis PR gene expression and disease resistance	48
Protein synthesis control in cancer: selectivity and therapeutic targeting	48
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	47

Structure and mechanism of a eukaryotic ceramide synthase complex	47
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	46
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation	46
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	46
c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells	45
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	44
LUBAC and NF‐κB trigger a nuclear response from mitochondria	44
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	44
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	43
The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast	43
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6	42
Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes	42
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	42
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	42
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	42
Nix interacts with WIPI2 to induce mitophagy	41
Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance	41
TFEB‐dependent lysosome biogenesis is required for senescence	41
R‐spondin signaling in the stomach: isthmal Lgr4 rules	41
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	41
The needs of a synapse—How local organelles serve synaptic proteostasis	41
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	40
Stem cells “aclymatise” to regenerate the blood system	40
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	40
Binary organization of epidermal basal domains highlights robustness to environmental exposure	39
PABP prevents the untimely decay of select mRNA populations in human cells	39
E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities	39
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	39
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	39
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint	39
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	38
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	38
A critical period of prehearing spontaneous Ca 2+ spiking is required for hair‐bundle maintenance in inner hair cells	38
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	38
Mitochondria and peroxisomes are NIXed for clearance	38
Mammalian antiviral RNAi is on the move	37
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila	37
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading	37
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	37
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	36
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	36
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	36
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	36
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	36
Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration	35
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion	35
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	35
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	35
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	34
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	34
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	34
Deciphering functional tumor states at single‐cell resolution	34
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	34
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication	33
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α	33
Quorum sensing componentry opens new lines of communication	33
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	33
Hold the fold: how delayed folding aids protein secretion	33
A sudden collapse: the disaggregation of amyloid fibres	33
Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	33
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	32
Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines	32
Two Hippo signaling modules orchestrate liver size and tumorigenesis	32
Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies	32
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	32
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	32
Fuel oxidation under the control of mitochondrial shape and dynamics	32
Pathogenic fungi neutralize plant‐derived ROS via Srpk1 deacetylation	32
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	32
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response	32
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	32
Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	32
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation	31
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component	31
Ca 2+ signals in plant immunity	31
An alternative UPF1 isoform drives conditional remodeling of nonsense‐mediated mRNA decay	31
Disulfiram bolsters T‐cell anti‐tumor immunity through direct activation of LCK‐mediated TCR signaling	31
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion	31
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases	31
Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress	31

TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	31
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding	31