OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Journal is 36. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	180
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	164
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	156
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	144
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase	117
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	115
The plant noncoding transcriptome: a versatile environmental sensor	110
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	109
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	107
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	106
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization	106
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	105
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	103
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	98
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	95
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	92
In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	86
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1‐SV2 plasma membrane nanocluster for synaptic vesicle entry	86
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	86
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	85
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	84
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	83
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	81
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori	80
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	79

Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking GTPase activity	76
Evolutionary adaptation of the protein folding pathway for secretability	75
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break formation	73
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	73
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	72
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation	72
Interferon‐inducible phospholipids govern IFITM3‐dependent endosomal antiviral immunity	70
Eating your mitochondria—when too much of a good thing turns bad	69
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	68
The Hippo pathway drives the cellular response to hydrostatic pressure	67
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	67
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression	67
Ribosome biogenesis factors—from names to functions	65
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	65
The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80	64
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	64
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	63
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	62
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	59
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	58
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	58
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	58
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	58
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3‐mediated plant senescence pathway	58
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	57
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	57
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	57
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	56
Erratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	54
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	53
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	53
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	53
Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila	52
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	52
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	52
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	51
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	51
Living a longer life: unique lessons from the naked mole‐rat blood system	50
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	50
Stress‐dependent macromolecular crowding in the mitochondrial matrix	49
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis PR gene expression and disease resistance	49
Structure and mechanism of a eukaryotic ceramide synthase complex	48
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	48
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	48
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	47
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	47
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6‐methyladenosine‐containing RNA virus	47
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	47
LUBAC and NF‐κB trigger a nuclear response from mitochondria	45
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	45

Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance	45
R‐spondin signaling in the stomach: isthmal Lgr4 rules	45
TFEB‐dependent lysosome biogenesis is required for senescence	44
Nix interacts with WIPI2 to induce mitophagy	44
A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cells	43
E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities	43
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	43
Binary organization of epidermal basal domains highlights robustness to environmental exposure	43
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	43
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	43
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	42
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	42
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	42
Mitochondria and peroxisomes are NIXed for clearance	41
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	41
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	41
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion	40
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	40
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	39
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	39
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	39
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	39
A sudden collapse: the disaggregation of amyloid fibres	39
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	39
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	39
Erratum To: Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	38
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	38
Hold the fold: how delayed folding aids protein secretion	37
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	37
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication	37
Quorum sensing componentry opens new lines of communication	37
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	37
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	37
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α	37
Fuel oxidation under the control of mitochondrial shape and dynamics	36
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	36
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation	36
AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5	36
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	36
Pathogenic fungi neutralize plant‐derived ROS via Srpk1 deacetylation	36
Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies	36
STAT1 is required to establish but not maintain interferon‐γ‐induced transcriptional memory	36
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	36
Erratum To: Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	36
Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress	36