EMBO Journal

Papers
(The TQCC of EMBO Journal is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Autophagy in major human diseases794
Molecular mechanisms and physiological functions of mitophagy709
m 6 A RNA methylation: from mechanisms to therapeutic potential394
Dynamic EMT: a multi‐tool for tumor progression385
Syncytia formation by SARS‐CoV‐2‐infected cells378
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells246
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast224
SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs215
Cell death pathways: intricate connections and disease implications183
Opposing activities of IFITM proteins in SARS‐CoV‐2 infection168
An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells158
SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation151
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation151
Cancer evolution: Darwin and beyond141
ATP and cancer immunosurveillance131
Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage129
On the role of phase separation in the biogenesis of membraneless compartments124
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner124
The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants113
Ca 2+ signals in plant immunity108
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition107
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation94
The multifaceted role of autophagy in cancer94
Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b92
BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis92
Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy86
Peering into tunneling nanotubes—The path forward85
Sealing holes in cellular membranes83
Cell softness regulates tumorigenicity and stemness of cancer cells82
Clock component OsPRR73 positively regulates rice salt tolerance by modulating OsHKT2;1 ‐mediated sodium homeostasis82
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses78
SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage78
The extracellular vesicle generation paradox: a bacterial point of view76
Structure of a human replisome shows the organisation and interactions of a DNA replication machine76
Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies76
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis75
DRP1 interacts directly with BAX to induce its activation and apoptosis75
Plant immunity suppression via PHR1‐RALF‐FERONIA shapes the root microbiome to alleviate phosphate starvation74
Fungal‐induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL‐2274
HOIL‐1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation73
BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡72
Flavonol‐mediated stabilization of PIN efflux complexes regulates polar auxin transport69
Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease68
Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila66
Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis65
Modulation of plant root growth by nitrogen source‐defined regulation of polar auxin transport64
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair64
The multi‐scale architecture of mammalian sperm flagella and implications for ciliary motility64
Paraspeckles are constructed as block copolymer micelles63
PIF1 helicase promotes break‐induced replication in mammalian cells62
CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawal62
Best practices for the visualization, mapping, and manipulation of R‐loops61
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling61
Syncytia formation by SARS‐CoV‐2‐infected cells61
Clustering and reverse transcription of HIV‐1 genomes in nuclear niches of macrophages61
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress‐induced damaged mitochondrial DNA60
HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations60
Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria60
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection59
Cell competition in intratumoral and tumor microenvironment interactions58
Golgi maturation‐dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH357
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration56
Ribosome biogenesis factors—from names to functions56
Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants55
Microglial MERTK eliminates phosphatidylserine‐displaying inhibitory post‐synapses55
Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology54
Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF54
Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis53
Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans52
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells52
Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl‐CoA50
5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING50
Single‐cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin‐driven circadian network49
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity48
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin48
CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos48
Identification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sites48
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity48
Extracellular vesicles and particles impact the systemic landscape of cancer47
A sensory cell diversifies its output by varying Ca 2+ influx‐release coupling among active zones47
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr147
BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis46
BNIP3L/NIX regulates both mitophagy and pexophagy46
Protein synthesis control in cancer: selectivity and therapeutic targeting46
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks46
Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway46
Expression of human‐specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility46
Centrosome defects cause microcephaly by activating the 53BP1‐USP28‐TP53 mitotic surveillance pathway46
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools45
Schwann cell precursors represent a neural crest‐like state with biased multipotency45
Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD2644
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens44
Activation of endogenous retroviruses during brain development causes an inflammatory response44
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response44
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration44
ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation44
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis44
Non‐canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus43
Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks43
Regulation of mitochondrial proteostasis by the proton gradient43
LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy43
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component42
Self‐assembly of multi‐component mitochondrial nucleoids via phase separation42
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency41
A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes41
Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features41
A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease41
m 6 A modification of HSATIII lncRNAs regulates temperature‐dependent splicing41
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification40
Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates40
Too much death can kill you: inhibiting intrinsic apoptosis to treat disease40
Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV‐1 infection40
Cellular stress promotes NOD1/2‐dependent inflammation via the endogenous metabolite sphingosine‐1‐phosphate40
Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy40
Nuclear cGAS: guard or prisoner?40
Transcriptional repression of NFKBIA triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence39
Endothelium‐derived lactate is required for pericyte function and blood–brain barrier maintenance38
N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation38
Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system38
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis38
RNA is required for the integrity of multiple nuclear and cytoplasmic membrane‐less RNP granules38
Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit37
Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency37
Photoreceptor nanotubes mediate the in vivo exchange of intracellular material37
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation37
A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies37
HASTY , the Arabidopsis EXPORTIN5 ortholog, regulates cell‐to‐cell and vascular microRNA movement36
Cryo‐EM structure of the CENP‐A nucleosome in complex with phosphorylated CENP‐C36
ADP‐ribosylation of histone variant H2AX promotes base excision repair36
Adjustment of the PIF7‐HFR1 transcriptional module activity controls plant shade adaptation36
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange36
m 6 A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region36
RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency35
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation35
Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding35
Reproducible image handling and analysis35
Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis35
Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress35
SNX10‐mediated LPS sensing causes intestinal barrier dysfunction via a caspase‐5‐dependent signaling cascade34
Ageing induces tissue‐specific transcriptomic changes in Caenorhabditis elegans34
ZDHHC18 negatively regulates cGAS‐mediated innate immunity through palmitoylation34
Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex34
USP8 promotes cancer progression and extracellular vesicle‐mediated CD8+ T cell exhaustion by deubiquitinating the TGF‐β receptor TβRII34
The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type‐III effector34
The birth of a giant: evolutionary insights into the origin of auxin responses in plants34
Selective cross‐linking of coinciding protein assemblies by in‐gel cross‐linking mass spectrometry34
Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis33
Dermal αSMA + myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production33
Cryo‐EM structure of native human uromodulin, a zona pellucida module polymer33
IFT54 directly interacts with kinesin‐II and IFT dynein to regulate anterograde intraflagellar transport32
PKM2‐TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability32
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA32
Barley stripe mosaic virus γb protein disrupts chloroplast antioxidant defenses to optimize viral replication32
Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification32
Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration32
Deciphering functional tumor states at single‐cell resolution31
Integrator is recruited to promoter‐proximally paused RNA Pol II to generate Caenorhabditis elegans piRNA precursors31
De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis31
Pathogenic ACVR1R206H activation by Activin A‐induced receptor clustering and autophosphorylation31
N 6 ‐methyladenosine modification of lncRNA Pvt1 governs epidermal stemness31
Unraveling the features of somatic transposition in the Drosophila intestine31
Phytosulfokine peptide optimizes plant growth and defense via glutamine synthetase GS2 phosphorylation in tomato30
m6A‐mediated alternative splicing coupled with nonsense‐mediated mRNA decay regulates SAM synthetase homeostasis30
Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane30
Histone chaperone CAF‐1 promotes HIV‐1 latency by leading the formation of phase‐separated suppressive nuclear bodies30
Architecture of the active post‐translational Sec translocon30
The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation30
Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption30
A stress‐induced tyrosine‐tRNA depletion response mediates codon‐based translational repression and growth suppression30
GRASP55 regulates intra‐Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis30
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models30
Helical ordering of envelope‐associated proteins and glycoproteins in respiratory syncytial virus30
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding30
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering‐induced Oma1 activation29
Bacteria elicit a phage tolerance response subsequent to infection of their neighbors29
PRMT1 promotes the tumor suppressor function of p14 ARF and is indicative for pancreatic cancer prognosis29
Multiplexed CRISPR/CAS9‐mediated engineering of pre‐clinical mouse models bearing native human B cell receptors29
Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression29
RNA‐based medicine: from molecular mechanisms to therapy29
ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration29
Tyr‐Asp inhibition of glyceraldehyde 3‐phosphate dehydrogenase affects plant redox metabolism29
IFN‐β rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp129
Torsin and NEP1R1‐CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid‐dependent and lipid‐independent mechanisms29
Biochemically validated structural model of the 15‐subunit intraflagellar transport complex IFT‐B29
Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex29
The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains29
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression29
Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab129
MitoStores: chaperone‐controlled protein granules store mitochondrial precursors in the cytosol28
The C‐degron pathway eliminates mislocalized proteins and products of deubiquitinating enzymes28
The glycine arginine‐rich domain of the RNA‐binding protein nucleolin regulates its subcellular localization28
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism‐like phenotype28
Chromosomal instability by mutations in the novel minor spliceosome component CENATAC28
Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress28
Ontogeny and function of the circadian clock in intestinal organoids28
Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad427
Translational adaptation to heat stress is mediated by RNA 5‐methylcytosine in Caenorhabditis elegans27
NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy27
CircPVT1 promotes ER‐positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS27
Rabl2 GTP hydrolysis licenses BBSome‐mediated export to fine‐tune ciliary signaling27
FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors27
An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣membrane27
Cancer‐associated POT1 mutations lead to telomere elongation without induction of a DNA damage response27
TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis27
Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates27
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS27
Employing core regulatory circuits to define cell identity27
Structural basis of TRAPPIII‐mediated Rab1 activation26
A switch from α‐helical to β‐strand conformation during co‐translational protein folding26
Host autophagy mediates organ wasting and nutrient mobilization for tumor growth26
Integrated requirement of non‐specific and sequence‐specific DNA binding in Myc‐driven transcription26
Ribosome slowdown triggers codon‐mediated mRNA decay independently of ribosome quality control26
Gut microbiota regulates blood‐cerebrospinal fluid barrier function and Aβ pathology26
Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation26
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies26
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets26
Exon‐independent recruitment of SRSF1 is mediated by U1 snRNP stem‐loop 326
Acetylcholine‐synthesizing macrophages in subcutaneous fat are regulated by β 2 ‐adrenergic signaling26
Prohibitin 1 regulates mtDNA release and downstream inflammatory responses26
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A26
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma25
Translation‐coupled mRNA quality control mechanisms25
The high‐energy transition state of the glutamate transporter homologue GltPh25
Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome25
Phospho‐regulation, nucleotide binding and ion access control in potassium‐chloride cotransporters25
A new linear cyclin docking motif that mediates exclusively S‐phase CDK‐specific signaling25
Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch25
Regulation of autophagosome biogenesis by OFD1‐mediated selective autophagy25
STING directly recruits WIPI2 for autophagosome formation during STING‐induced autophagy25
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues25
Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases25
Oxidative stress protein Oxr1 promotes V‐ATPase holoenzyme disassembly in catalytic activity‐independent manner25
Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates25
1‐Undecene from Pseudomonas aeruginosa is an olfactory signal for flight‐or‐fight response in Caenorhabditis elegans25
Dual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins25
CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system25
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