OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Journal is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR	194
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	175
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK	175
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4 ⁺	161
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB	148
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	139
PGE ₂ ‐EP3 axis promotes brown adipose tissue formation through stabil	134
The plant noncoding transcriptome: a versatile environmental sensor	126
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	123
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	116
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and	113
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	104
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	102
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research	99
TDAG51 promotes transcription factor FoxO1 activity during LPS ‐ind	97
The SMC5 /6 complex recruits the PAF1 complex to facilitate DNA	94
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	93
In vivo reduction of RAD51 ‐mediated homologous recombination triggers aging but impairs oncogenesis	93
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC	93
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma m	90
IDH2 stabilizes HIF ‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	89
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity	87
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	87
CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system	87
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking	87

Evolutionary adaptation of the protein folding pathway for secretability	86
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion	84
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	83
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	83
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	81
Eating your mitochondria—when too much of a good thing turns bad	80
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	79
Interferon‐inducible phospholipids govern IFITM3 ‐dependent endosomal antiviral immunity	74
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	74
MARCH5 ‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7	73
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break format	72
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	72
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in	71
The Hippo pathway drives the cellular response to hydrostatic pressure	69
Strigolactones promote plant freezing tolerance by releasing the WRKY41 ‐mediated inhibition of CB	68
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	67
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	66
Ribosome biogenesis factors—from names to functions	66
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	65
DRP1 interacts directly with BAX to induce its activation and apoptosis	64
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	64
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	63
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	62
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	62
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	61
The CTLA ‐4 immune checkpoint protein regulates PD‐L1 : PD	60
Autophagy power expands: fuse those cells!	59
LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function	59
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	59
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3 ‐mediated plant senescence pathway	59
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	57
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	57
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	57
Structure and mechanism of a eukaryotic ceramide synthase complex	56
Subcellular localization of Type VI secretion system assembly in response to cell–cell contact	56
Evidence for existence of an apoptosis‐inducing BH3 ‐only protein, sayonara , in <	55
Living a longer life: unique lessons from the naked mole‐rat blood system	55
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	55
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	53
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	53
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus	51
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis<	51
c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells	50
Stress‐dependent macromolecular crowding in the mitochondrial matrix	50
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	50
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	50
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	49
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	49
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	48
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	48

Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	48
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	48
Protein synthesis control in cancer: selectivity and therapeutic targeting	47
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation	46
Extra centrosomes induce PIDD1 ‐mediated inflammation and immunosurveillance	46
The needs of a synapse—How local organelles serve synaptic proteostasis	45
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	44
R‐spondin signaling in the stomach: isthmal Lgr4 rules	44
The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast	44
Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes	44
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	43
Nix interacts with WIPI2 to induce mitophagy	43
CRIP1 suppresses BBOX1 ‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	43
LUBAC and NF‐κB trigger a nuclear response from mitochondria	43
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	42
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6	42
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	42
TFEB ‐dependent lysosome biogenesis is required for senescence	41
E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities	41
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint	41
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	41
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	41
Binary organization of epidermal basal domains highlights robustness to environmental exposure	40
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	40
PABP prevents the untimely decay of select mRNA populations in human cells	40
Stem cells “aclymatise” to regenerate the blood system	40
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	40
A critical period of prehearing spontaneous Ca ²⁺ spiking is required for hair‐bundle maintenance in inner hair cells	40
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	39
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	39
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila	38
NALCN ‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	38
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	38
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	38
Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration	38
Mammalian antiviral RNAi is on the move	38
Mitochondria and peroxisomes are NIXed for clearance	37
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	37
SHP ‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	37
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading	37
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	37
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	36
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	35
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	35
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	35
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	35
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhanci	35
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	35
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	35
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	35
Spatial and temporal control of mitochondrial H ₂ O ₂ release in intact human cells	35
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	34
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response	34
Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	34
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	34
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	34
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA ‐mediated mitochondrial–nuclear communication	33
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HI	33
Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	33
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	33
Quorum sensing componentry opens new lines of communication	33
Fuel oxidation under the control of mitochondrial shape and dynamics	33
A sudden collapse: the disaggregation of amyloid fibres	33
Hold the fold: how delayed folding aids protein secretion	33
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	32
Pathogenic fungi neutralize plant‐derived ROS via Srpk1 deacetylation	32
Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies	32
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases	32
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding	32
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	32
Two Hippo signaling modules orchestrate liver size and tumorigenesis	32
An alternative UPF1 isoform drives conditional remodeling of nonsense‐mediated mRNA decay	32
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion	32
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component	32
Disulfiram bolsters T‐cell anti‐tumor immunity through direct activation of LCK‐mediated TCR signaling	32