EMBO Journal

Article	Citations
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	218
PGE 2 ‐EP3 axis promotes brown adipose tissue formation through stabil	204
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and	174
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB	160
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4 +	155
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK	140
The plant noncoding transcriptome: a versatile environmental sensor	113
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	113
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR	109
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	108
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	104
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	101
TDAG51 promotes transcription factor FoxO1 activity during LPS ‐ind	101
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	101
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma m	98
IDH2 stabilizes HIF ‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	96
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	92
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	88
In vivo reduction of RAD51 ‐mediated homologous recombination triggers aging but impairs oncogenesis	87
The SMC5 /6 complex recruits the PAF1 complex to facilitate DNA	86
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC	83
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	83
Eating your mitochondria—when too much of a good thing turns bad	83
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break format	82
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	81

A network of small RNAs regulates sporulation initiation in Clostridioides difficile	78
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking	76
Interferon‐inducible phospholipids govern IFITM3 ‐dependent endosomal antiviral immunity	75
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	73
The Hippo pathway drives the cellular response to hydrostatic pressure	73
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	72
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in	72
MARCH5 ‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7	69
Ribosome biogenesis factors—from names to functions	69
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	69
Evolutionary adaptation of the protein folding pathway for secretability	66
Strigolactones promote plant freezing tolerance by releasing the WRKY41 ‐mediated inhibition of CB	65
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	65
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	65
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	65
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	64
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	63
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	63
Autophagy power expands: fuse those cells!	62
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	61
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	59
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	58
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	58
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3 ‐mediated plant senescence pathway	57
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	57
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	56
Structure and mechanism of a eukaryotic ceramide synthase complex	56
Stress‐dependent macromolecular crowding in the mitochondrial matrix	56
The CTLA ‐4 immune checkpoint protein regulates PD‐L1 : PD	56
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	55
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in  Arabidopsis	54
Living a longer life: unique lessons from the naked mole‐rat blood system	52
Subcellular localization of Type VI secretion system assembly in response to cell–cell contact	52
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	52
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	51
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	51
Evidence for existence of an apoptosis‐inducing BH3 ‐only protein, sayonara , in <	51
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	50
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis<	49
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	49
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	49
R‐spondin signaling in the stomach: isthmal Lgr4 rules	48
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	48
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	48
LUBAC and NF‐κB trigger a nuclear response from mitochondria	48
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	48
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	47
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	46
Nix interacts with WIPI2 to induce mitophagy	46
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6	46

DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	45
CRIP1 suppresses BBOX1 ‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	45
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	45
Extra centrosomes induce PIDD1 ‐mediated inflammation and immunosurveillance	44
TFEB ‐dependent lysosome biogenesis is required for senescence	44
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	43
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	43
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	43
E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities	42
A critical period of prehearing spontaneous Ca 2+ spiking is required for hair‐bundle maintenance in inner hair cells	42
Binary organization of epidermal basal domains highlights robustness to environmental exposure	42
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	42
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	42
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	41
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	41
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	41
Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration	41
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	41
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	40
Mitochondria and peroxisomes are NIXed for clearance	40
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	39
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	39
NALCN ‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	39
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	39
SHP ‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	39
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	38
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhanci	38
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	38
A sudden collapse: the disaggregation of amyloid fibres	37
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	37
Hold the fold: how delayed folding aids protein secretion	37
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	37
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HI	37
Quorum sensing componentry opens new lines of communication	37
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	37
Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	37
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	36
Two Hippo signaling modules orchestrate liver size and tumorigenesis	36
Disulfiram bolsters T‐cell anti‐tumor immunity through direct activation of LCK‐mediated TCR signaling	36
STAT1 is required to establish but not maintain interferon‐γ‐induced transcriptional memory	36
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA ‐mediated mitochondrial–nuclear communication	36
Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	36
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion	36
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	36
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	36
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	36
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation	36
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases	36
Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress	35
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding	35
Fuel oxidation under the control of mitochondrial shape and dynamics	35
Pathogenic fungi neutralize plant‐derived ROS via Srpk1 deacetylation	35
Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies	35
AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5	35
Anti‐hsa‐miR ‐59 alleviates premature senescence associated with Hutchinson‐Gilford progeria syndrome in mice	34
Ca 2+ signals in plant immunity	34
Mitotic checkpoint gene expression is tuned by codon usage bias	34
Recycling of the actin monomer pool limits the lifetime of network turnover	34
LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation	34
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component	34
An accessory prefrontal cortex–thalamus circuit sculpts maternal behavior in virgin female mice	33
Sweet‐talk in the time of cholera: host mucin negotiates peace with Vibrio cholerae	33
Spo13/ MEIKIN ensures a Two‐Division meiosis by preventing the activation of <	33
Autophagy regulates neuronal excitability by controlling cAMP /protein kinase A signaling at the synapse	33
Retromer oligomerization drives SNX‐BAR coat assembly and membrane constriction	33
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor	33
Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome	33
You can “tail” them apart: paralog‐specific functions of CRL4B ubiquitin ligases during mitosis and brain development	33
Cryo‐EM structure of antibacterial efflux transporter QacA from Staphylococcus aureus	32
Fecal microbiota transplantation enhances cell therapy in a rat model of hypoganglionosis by SCFA ‐induced MEK1	32
Host cell egress of Brucella abortus requires BNIP3L ‐mediated mitophagy	32
Creativity as an antidote to research becoming too predictable	32
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters	32
microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes	32
T‐cell antigen recognition: catch‐as‐catch‐can or catch‐22?	31
RNase H2 degrades toxic RNA : DNA hybrids behind stalled forks to p	31
High‐throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory‐deprived cortical cholinergic VIP/CHAT neurons	31
Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness	31
Thiol reductive stress activates the hypoxia response pathway	30
Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV ‐1 reservoirs for v	30

Nucleoporin foci are stress‐sensitive condensates dispensable for C. elegans nuclear pore assembly	30
Auxin‐dependent regulation of cell division rates governs root thermomorphogenesis	30
Tau target identification reveals NSF ‐dependent effects on AMPA receptor trafficking and memory f	30
Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes	30
The BCL ‐2 family member BID plays a role during embryonic development in addition to its	30
Regulation of mitochondrial proteostasis by the proton gradient	30
Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding	30
A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans	30
ARFs get the BioID treatment: what have we been missing?	29
Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL ‐1β release in X‐linked inhibitor of apoptosis (	29
NME6: ribonucleotide salvage sustains mitochondrial transcription	29
Condensin pinches a short negatively supercoiled DNA loop during each round of ATP usage	29
Acetylation coordinates the crosstalk between carbon metabolism and ammonium assimilation in Salmonella enterica	29
Role of PCIF1 ‐mediated 5′‐cap N6 ‐methyladeonsine mRNA	29
Termination of STING responses is mediated via ESCRT ‐dependent degradation	29
The adaptive strategies of cells in the face of CIN	28
Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure	28
Making liver cancer cells go ARGh !	28
Infection and inflammation stimulate expansion of a CD74 + Paneth cell subset to regulate disease progression	28
Tau: a phase in the crowd	28
Nucleic acid–protein condensates in innate immune signaling	28
m6A is required for resolving progenitor identity during planarian stem cell differentiation	28
The ASC‐1 complex promotes translation initiation by scanning ribosomes	28
Promoter‐pervasive transcription causes RNA polymerase II pausing to boost	28
Adaptive pathfinding by nucleokinesis during amoeboid migration	28
Macrophage‐derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection	28
The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target	28
TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis	27
A systematic proximity ligation approach to studying protein‐substrate specificity identifies the substrate spectrum of the Ssh1 translocon	27
ER exit sites take the strain	27
A Zn‐dependent structural transition of SOD1 modulates its ability to undergo phase separation	27
Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the ubiquitin‐proteasome system	27
AATF /Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma	27
A tale of two Hippo pathway modules	27
Regulation of membrane fluidity by RNF145 ‐triggered degradation of the lipid hydrolase ADIPOR2	27
Two Hippo signaling modules orchestrate liver size and tumorigenesis	27
The CUL4B ‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho	26
The MASTL / PP2A cell cycle kinase‐phosphatase module restrains PI3K‐Akt<	26
Suppression of Ca 2+ signaling enhances melanoma progression	26
Barley GRIK1‐SnRK1 kinases subvert a viral virulence protein to upregulate antiviral RNAi and inhi	26
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	26
Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns	26
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular	26
Extracellular vesicles and co‐isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells	26
Cell line authentication: a necessity for reproducible biomedical research	26
Actin network architecture can ensure robust centering or sensitive decentering of the centrosome	26
Centrosome linker diversity and its function in centrosome clustering and mitotic spindle formation	25
Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons	25
Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates	25
Structure and functional mapping of the KRAB‐KAP1 repressor complex	25
Epigenetic escape of immunosurveillance by malignant cell precursors	25
GPNMB + Gal‐3 + hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogene	25
Nicotinamide N‐methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer	25
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation	25
Condensate functionalization with microtubule motors directs their nucleation in space and allows manipulating RNA localization	25
Damage‐induced regeneration of the intestinal stem cell pool through enteroblast mitosis in the Drosophila midgut	24
Neil J. Bulleid (1960–2023), a virtuoso of protein folding and redox biology	24
Long noncoding RNA‐mediated epigenetic regulation of auxin‐related genes controls shade avoidance syndrome in Arabidopsis	24
YAP / BRD4 ‐controlled ROR1 promotes tumor‐initiating cells and hyp	24
USP8 promotes cancer progression and extracellular vesicle‐mediated CD8 + T cell exhaustion by deubiquitinating the	24
Chromatin remodeling is required for sRNA ‐guided DNA elimination in Parame	24
A small RNA system ensures accurate homologous pairing and unpaired silencing of meiotic chromosomes	24
Phosphorylation controls spatial and temporal activities of motor‐PRC1 complexes to complete mitosis	24
Neuron‐specific translational control shift ensures proteostatic resilience during ER stress	24
High air humidity dampens salicylic acid pathway and NPR1 function to promote plant disease	24
The notorious R.N.A.	24
Adaptation to high rates of chromosomal instability and aneuploidy through multiple pathways in budding yeast	24
Attenuation of SARS‐CoV ‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases	24
eIF3 mRNA selectivity profiling reveals eIF3k as a cancer‐relevant regulator of ribosome content	24
Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the polar body extrusion pathway	23
HERC3 promotes YAP / TAZ stability and tumorigenesis independently	23
Aberrant DNA N 6 ‐methyladenine incorporation via adenylate kinase 1 is suppressed by ADAL deaminase‐dependent 2′‐deoxynucleotide pool sanitation	23
Rap1 prevents fusions between long telomeres in fission yeast	23
An ERK1/2‐driven RNA‐binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene	23
TSG101 associates with PARP1 and is essential for PARylation and	23
Gut microbiota regulates blood‐cerebrospinal fluid barrier function and Aβ pathology	23
LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates	23
WRKY transcription factors and OBERON histone‐binding proteins form complexes to balance plant growth and stress toler	23
Prohibitin 1 regulates mtDNA release and downstream inflammatory responses	23
TOR acts as a metabolic gatekeeper for auxin‐dependent lateral root initiation in Arabidopsis thaliana	22
Chemogenetic profiling reveals PP2A‐independent cytotoxicity of proposed PP2A activators iHAP1 and DT‐061	22
Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells	22
A tryptophan metabolite made by a gut microbiome eukaryote induces pro‐inflammatory T cells	22
YTHDF2 / m 6 A /	22
Phytosulfokine peptide optimizes plant growth and defense via glutamine synthetase GS2 phosphorylation in tomato	22
C. elegans molting requires rhythmic accumulation of the Grainyhead/ LSF transcription factor GRH	22
RNA ‐based medicine: from molecular mechanisms to therapy	22
Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory	22
“Be sustainable”: EOSC‐Life recommendations for implementation of FAIR principles in life science	21
Loss of TDP‐43 oligomerization or RNA binding elicits distinct aggregation patterns	21
Characterization of naked mole‐rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits	21
Regeneration of the human segmentation clock in somitoids in vitro	21
Cadherin‐mediated adhesion takes control	21
Acquired stress resilience through bacteria‐to‐nematode interdomain horizontal gene transfer	21
Oxidative stress‐induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1	21