EMBO Journal

Article	Citations
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	180
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	164
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	156
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	144
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase	117
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	115
The plant noncoding transcriptome: a versatile environmental sensor	110
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	109
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	107
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	106
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization	106
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	105
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	103
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	98
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	95
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	92
In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	86
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1‐SV2 plasma membrane nanocluster for synaptic vesicle entry	86
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	86
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	85
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	84
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	83
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	81
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori	80
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	79

Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking GTPase activity	76
Evolutionary adaptation of the protein folding pathway for secretability	75
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	73
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break formation	73
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation	72
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	72
Interferon‐inducible phospholipids govern IFITM3‐dependent endosomal antiviral immunity	70
Eating your mitochondria—when too much of a good thing turns bad	69
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	68
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression	67
The Hippo pathway drives the cellular response to hydrostatic pressure	67
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	67
Ribosome biogenesis factors—from names to functions	65
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	65
The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80	64
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	64
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	63
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	62
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	59
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	58
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	58
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	58
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	58
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3‐mediated plant senescence pathway	58
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	57
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	57
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	57
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	56
Erratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	54
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	53
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	53
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	53
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	52
Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila	52
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	52
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	51
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	51
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	50
Living a longer life: unique lessons from the naked mole‐rat blood system	50
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis PR gene expression and disease resistance	49
Stress‐dependent macromolecular crowding in the mitochondrial matrix	49
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	48
Structure and mechanism of a eukaryotic ceramide synthase complex	48
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	48
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	47
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	47
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6‐methyladenosine‐containing RNA virus	47
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	47
LUBAC and NF‐κB trigger a nuclear response from mitochondria	45
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	45

Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance	45
R‐spondin signaling in the stomach: isthmal Lgr4 rules	45
TFEB‐dependent lysosome biogenesis is required for senescence	44
Nix interacts with WIPI2 to induce mitophagy	44
A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cells	43
E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities	43
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	43
Binary organization of epidermal basal domains highlights robustness to environmental exposure	43
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	43
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	43
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	42
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	42
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	42
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	41
Mitochondria and peroxisomes are NIXed for clearance	41
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	41
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	40
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion	40
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	39
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	39
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	39
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	39
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	39
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	39
A sudden collapse: the disaggregation of amyloid fibres	39
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	38
Erratum To: Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	38
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	37
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α	37
Hold the fold: how delayed folding aids protein secretion	37
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	37
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication	37
Quorum sensing componentry opens new lines of communication	37
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	37
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	36
Erratum To: Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	36
Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress	36
Fuel oxidation under the control of mitochondrial shape and dynamics	36
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	36
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation	36
AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5	36
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	36
Pathogenic fungi neutralize plant‐derived ROS via Srpk1 deacetylation	36
Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies	36
STAT1 is required to establish but not maintain interferon‐γ‐induced transcriptional memory	36
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding	35
Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome	35
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion	35
Two Hippo signaling modules orchestrate liver size and tumorigenesis	35
Fecal microbiota transplantation enhances cell therapy in a rat model of hypoganglionosis by SCFA‐induced MEK1/2 signaling pathway	35
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases	35
Spo13/MEIKIN ensures a Two‐Division meiosis by preventing the activation of APC/CAma1 at meiosis I	35
You can “tail” them apart: paralog‐specific functions of CRL4B ubiquitin ligases during mitosis and brain development	34
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters	34
Sweet‐talk in the time of cholera: host mucin negotiates peace with Vibrio cholerae	34
Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse	34
LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation	34
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr1	34
microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes	34
Retromer oligomerization drives SNX‐BAR coat assembly and membrane constriction	33
Host cell egress of Brucella abortus requires BNIP3L‐mediated mitophagy	33
Cryo‐EM structure of antibacterial efflux transporter QacA from Staphylococcus aureus reveals a novel extracellular loop with allosteric role	33
Recycling of the actin monomer pool limits the lifetime of network turnover	32
Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding	32
An accessory prefrontal cortex–thalamus circuit sculpts maternal behavior in virgin female mice	32
Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency	32
Creativity as an antidote to research becoming too predictable	32
Mitotic checkpoint gene expression is tuned by codon usage bias	32
Anti‐hsa‐miR‐59 alleviates premature senescence associated with Hutchinson‐Gilford progeria syndrome in mice	32
High‐throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory‐deprived cortical cholinergic VIP/CHAT neurons	31
A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans	31
Nucleoporin foci are stress‐sensitive condensates dispensable for C. elegans nuclear pore assembly	31
Tau target identification reveals NSF‐dependent effects on AMPA receptor trafficking and memory formation	31
Auxin‐dependent regulation of cell division rates governs root thermomorphogenesis	31
Termination of STING responses is mediated via ESCRT‐dependent degradation	31
Regulation of mitochondrial proteostasis by the proton gradient	31
Thiol reductive stress activates the hypoxia response pathway	30
T‐cell antigen recognition: catch‐as‐catch‐can or catch‐22?	30
Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV‐1 reservoirs for virus dissemination	30
RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart	30

Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness	30
The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK and BOK	30
Acetylation coordinates the crosstalk between carbon metabolism and ammonium assimilation in Salmonella enterica	30
Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes	30
A systematic proximity ligation approach to studying protein‐substrate specificity identifies the substrate spectrum of the Ssh1 translocon	30
m6A is required for resolving progenitor identity during planarian stem cell differentiation	29
Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2	29
The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target	29
The ASC‐1 complex promotes translation initiation by scanning ribosomes	29
Macrophage‐derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection	29
Adaptive pathfinding by nucleokinesis during amoeboid migration	29
The adaptive strategies of cells in the face of CIN	29
Promoter‐pervasive transcription causes RNA polymerase II pausing to boost DOG1 expression in response to salt	29
Erratum To: Two Hippo signaling modules orchestrate liver size and tumorigenesis	29
Condensin pinches a short negatively supercoiled DNA loop during each round of ATP usage	29
Making liver cancer cells go ARGh!	29
Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression	28
Role of PCIF1‐mediated 5′‐cap N6‐methyladeonsine mRNA methylation in colorectal cancer and anti‐PD‐1 immunotherapy	28
NME6: ribonucleotide salvage sustains mitochondrial transcription	28
ARFs get the BioID treatment: what have we been missing?	28
Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure	28
Nucleic acid–protein condensates in innate immune signaling	28
Structure and functional mapping of the KRAB‐KAP1 repressor complex	27
A Zn‐dependent structural transition of SOD1 modulates its ability to undergo phase separation	27
Erratum To: Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway	27
ER exit sites take the strain	27
Extracellular vesicles and co‐isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells	27
A tale of two Hippo pathway modules	27
Nicotinamide N‐methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer	27
Actin network architecture can ensure robust centering or sensitive decentering of the centrosome	27
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	27
The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs	26
Suppression of Ca2+ signaling enhances melanoma progression	26
TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis	26
Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the ubiquitin‐proteasome system	26
The MASTL/PP2A cell cycle kinase‐phosphatase module restrains PI3K‐Akt activity in an mTORC1‐dependent manner	26
AATF/Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma	26
Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns	26
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation	26
Cell line authentication: a necessity for reproducible biomedical research	26
YAP/BRD4‐controlled ROR1 promotes tumor‐initiating cells and hyperproliferation in pancreatic cancer	25
eIF3 mRNA selectivity profiling reveals eIF3k as a cancer‐relevant regulator of ribosome content	25
Damage‐induced regeneration of the intestinal stem cell pool through enteroblast mitosis in the Drosophila midgut	25
Phosphorylation controls spatial and temporal activities of motor‐PRC1 complexes to complete mitosis	25
Long noncoding RNA‐mediated epigenetic regulation of auxin‐related genes controls shade avoidance syndrome in Arabidopsis	25
Neuron‐specific translational control shift ensures proteostatic resilience during ER stress	25
Chromatin remodeling is required for sRNA‐guided DNA elimination in Paramecium	25
Epigenetic escape of immunosurveillance by malignant cell precursors	25
Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates	25
Centrosome linker diversity and its function in centrosome clustering and mitotic spindle formation	25
Barley GRIK1‐SnRK1 kinases subvert a viral virulence protein to upregulate antiviral RNAi and inhibit infection	25
Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons	25
USP8 promotes cancer progression and extracellular vesicle‐mediated CD8+ T cell exhaustion by deubiquitinating the TGF‐β receptor TβRII	25
GPNMB+Gal‐3+ hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogenesis	25
Condensate functionalization with microtubule motors directs their nucleation in space and allows manipulating RNA localization	25
Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases	25
Prohibitin 1 regulates mtDNA release and downstream inflammatory responses	24
Adaptation to high rates of chromosomal instability and aneuploidy through multiple pathways in budding yeast	24
The notorious R.N.A.	24
Aberrant DNA N6‐methyladenine incorporation via adenylate kinase 1 is suppressed by ADAL deaminase‐dependent 2′‐deoxynucleotide pool sanitation	24
Gut microbiota regulates blood‐cerebrospinal fluid barrier function and Aβ pathology	24
TSG101 associates with PARP1 and is essential for PARylation and DNA damage‐induced NF‐κB activation	24
An ERK1/2‐driven RNA‐binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene	24
Rap1 prevents fusions between long telomeres in fission yeast	24
Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the polar body extrusion pathway	24
Neil J. Bulleid (1960–2023), a virtuoso of protein folding and redox biology	24
High air humidity dampens salicylic acid pathway and NPR1 function to promote plant disease	24
C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH‐1	23
LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates	23
HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity	23
WRKY transcription factors and OBERON histone‐binding proteins form complexes to balance plant growth and stress tolerance	23
A tryptophan metabolite made by a gut microbiome eukaryote induces pro‐inflammatory T cells	23
A small RNA system ensures accurate homologous pairing and unpaired silencing of meiotic chromosomes	23
YTHDF2/m6A/NF‐κB axis controls anti‐tumor immunity by regulating intratumoral Tregs	22
Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells	22
Phase separation of Hippo signalling complexes	22
RNA‐based medicine: from molecular mechanisms to therapy	22
Chemogenetic profiling reveals PP2A‐independent cytotoxicity of proposed PP2A activators iHAP1 and DT‐061	22
Nuclear pore complex acetylation regulates mRNA export and cell cycle commitment in budding yeast	22
RNF26 binds perinuclear vimentin filaments to integrate ER and endolysosomal responses to proteotoxic stress	22
TOR acts as a metabolic gatekeeper for auxin‐dependent lateral root initiation in Arabidopsis thaliana	22
Structural basis of ubiquitin‐independent PP1 complex disassembly by p97	22
Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non‐ and anti‐adipogenic in age‐dependent manner	22