EMBO Journal

Article	Citations
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	885
Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2	426
PABP prevents the untimely decay of select mRNA populations in human cells	256
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	239
The ASC‐1 complex promotes translation initiation by scanning ribosomes	151
Binary organization of epidermal basal domains highlights robustness to environmental exposure	151
NDST3 deacetylates α‐tubulin and suppresses V‐ATPase assembly and lysosomal acidification	141
“Be sustainable”: EOSC‐Life recommendations for implementation of FAIR principles in life science data handling	140
Hematopoietic stem and progenitor cells integrate microbial signals to promote post‐inflammation gut tissue repair	131
Cryo‐EM structures of perforin‐2 in isolation and assembled on a membrane suggest a mechanism for pore formation	129
Systematic identification and characterization of repressive domains in Drosophila transcription factors	116
m6A is required for resolving progenitor identity during planarian stem cell differentiation	107
The goodies of chelated fat: iron‐regulated lipid droplet biogenesis precedes and preserves mitophagy	99
Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure	94
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	92
The plant noncoding transcriptome: a versatile environmental sensor	92
Role of PCIF1‐mediated 5′‐cap N6‐methyladeonsine mRNA methylation in colorectal cancer and anti‐PD‐1 immunotherapy	89
The Ras GTPase‐activating‐like protein IQGAP1 bridges Gasdermin D to the ESCRT system to promote IL‐1β release via exosomes	89
A tale of two inhibitors: diarylquinolines and squaramides	83
Transport unplugged: KCCs are regulated through an N‐terminal plug of the ion pathway	83
Richard Jackson (1940–2020) ‐ A towering presence in translation	83
The adaptive strategies of cells in the face of CIN	80
Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer	79
Making liver cancer cells go ARGh!	76
Stem cells “aclymatise” to regenerate the blood system	76

ARFs get the BioID treatment: what have we been missing?	76
APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release	75
What (H)IF isoform matters? A deubiquitinase can tune the hypoxic response	75
Kinetochore individualization in meiosis I is required for centromeric cohesin removal in meiosis II	73
Acquired stress resilience through bacteria‐to‐nematode interdomain horizontal gene transfer	72
Suppressing toxic aggregates: let MIA do it!	71
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration	70
ER‐anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6	69
Microglial TNFα orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep	68
Immune synaptopathies: how maternal immune activation impacts synaptic function during development	67
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	65
Characterization of naked mole‐rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits	64
The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22	63
Tubulin polyglutamylation differentially regulates microtubule‐interacting proteins	63
Widespread use of unconventional targeting signals in mitochondrial ribosome proteins	62
AMPK CA(R)Sts a new light on amino acid sensing	61
NME6: ribonucleotide salvage sustains mitochondrial transcription	60
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint	60
SPICE‐Met: profiling and imaging energy metabolism at the single‐cell level using a fluorescent reporter mouse	60
The eukaryotic replisome tolerates leading‐strand base damage by replicase switching	59
A systematic proximity ligation approach to studying protein‐substrate specificity identifies the substrate spectrum of the Ssh1 translocon	59
Nucleic acid–protein condensates in innate immune signaling	58
Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed	57
PHGDH and cancer: new job for an old enzyme!	56
ADPGK‐AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth	56
Cadherin‐mediated adhesion takes control	56
Nascent polypeptide within the exit tunnel stabilizes the ribosome to counteract risky translation	55
Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis	54
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	54
Changes in adenoviral chromatin organization precede early gene activation upon infection	54
Macrophage‐derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection	54
A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies	53
Employing core regulatory circuits to define cell identity	52
Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression	49
Mammalian ATG8 proteins maintain autophagosomal membrane integrity through ESCRTs	48
An engineered multicellular stem cell niche for the 3D derivation of human myogenic progenitors from iPSCs	48
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization	48
Adaptive pathfinding by nucleokinesis during amoeboid migration	47
Genetic control of the pluripotency epigenome determines differentiation bias in mouse embryonic stem cells	46
The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis	46
High‐resolution mapping of function and protein binding in an RNA nuclear enrichment sequence	46
Tau: a phase in the crowd	46
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase	46
DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability	45
PKM2‐TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability	45
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	44
HASTY , the Arabidopsis EXPORTIN5 ortholog, regulates cell‐to‐cell and vascular microRNA movement	44
miR‐124‐dependent tagging of synapses by synaptopodin enables input‐specific homeostatic plasticity	44
A CRMP4‐dependent retrograde axon‐to‐soma death signal in amyotrophic lateral sclerosis	44
Ubiquitin‐targeted bacterial effectors: rule breakers of the ubiquitin system	44

Oxidative stress‐induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2	43
Blood endothelial ALK1‐BMP4 signaling axis regulates adult hair follicle stem cell activation	43
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis	43
Promoter‐pervasive transcription causes RNA polymerase II pausing to boost DOG1 expression in response to salt	43
Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV‐1 pathogenesis	42
PECAM‐1 supports leukocyte diapedesis by tension‐dependent dephosphorylation of VE‐cadherin	42
BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡	42
Cryo‐EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms	41
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	41
E‐cadherin mediates apical membrane initiation site localisation duringde novopolarisation of epithelial cavities	41
Condensin pinches a short negatively supercoiled DNA loop during each round of ATP usage	41
Regeneration of the human segmentation clock in somitoids in vitro	40
A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cells	40
Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis	40
Sharpening the blades of the dentate gyrus: how adult‐born neurons differentially modulate diverse aspects of hippocampal learning and memory	40
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens	40
Multi‐modal adaptor‐clathrin contacts drive coated vesicle assembly	40
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	40
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	40
Cooperative amyloid fibre binding and disassembly by the Hsp70 disaggregase	39
PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522	38
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation	38
Viral recognition and the antiviral interferon response	38
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis	38
Astrogenesis in the murine dentate gyrus is a life‐long and dynamic process	37
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	37
Photoreceptor nanotubes mediate the in vivo exchange of intracellular material	37
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	37
The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target	37
Arabidopsis HEAT SHOCK FACTOR BINDING PROTEIN is required to limit meiotic crossovers and HEI10 transcription	36
Sealing holes in cellular membranes	36
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	36
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	36
MICa/b‐dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to autoimmunity	35
Calcium signals regulate the functional differentiation of thymic iNKT cells	35
Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans	35
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	35
Too much death can kill you: inhibiting intrinsic apoptosis to treat disease	34
On the role of phase separation in the biogenesis of membraneless compartments	34
Loss of TDP‐43 oligomerization or RNA binding elicits distinct aggregation patterns	33
DNA‐PKcs and ATM modulate mitochondrial ADP‐ATP exchange as an oxidative stress checkpoint mechanism	33
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast	32
Two Hippo signaling modules orchestrate liver size and tumorigenesis	32
E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation	32
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin	32
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner	32
BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α	32
Syncytia formation by SARS‐CoV‐2‐infected cells	31
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research	31
A heterotypic assembly mechanism regulates CHIP E3 ligase activity	31
In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	31
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	31
Unraveling the features of somatic transposition in the Drosophila intestine	31
Programmable C‐to‐U RNA editing using the human APOBEC3A deaminase	31
IFN‐β rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1	30
Helical ordering of envelope‐associated proteins and glycoproteins in respiratory syncytial virus	30
N4BP1 mediates RAM domain‐dependent notch signaling turnover during neocortical development	30
Mitochondria and peroxisomes are NIXed for clearance	30
Cell envelope growth of Gram‐negative bacteria proceeds independently of cell wall synthesis	30
High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane	30
Suppression of Ca2+ signaling enhances melanoma progression	30
TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis	29
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	29
ER exit sites take the strain	29
A Golgi oxygen sensor controls intestinal mucin glycosylation	29
Histone chaperone CAF‐1 promotes HIV‐1 latency by leading the formation of phase‐separated suppressive nuclear bodies	29
Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the ubiquitin‐proteasome system	29
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	29
Mechanism of transcription initiation and primer generation at the mitochondrial replication origin OriL	29
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	29
The fifth decade	29
Disulfiram's journey from rubber vulcanization to T‐cell activation	29
Classics never get old: neurotransmitters shape human cortical interneuron migration	28
Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II	28
AATF/Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma	28
Novel transient cytoplasmic rings stabilize assembling bacterial flagellar motors	28
The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion	28
Actin network architecture can ensure robust centering or sensitive decentering of the centrosome	28
Keep the fate: how chromatin regulators safeguard embryonic stem cell identity	28
Torsin and NEP1R1‐CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid‐dependent and lipid‐independent mechanisms	28

Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	28
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis	27
Reciprocal priming between receptor tyrosine kinases at recycling endosomes orchestrates cellular signalling outputs	27
PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid	27
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	27
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	27
Evidence for low nanocompaction of heterochromatin in living embryonic stem cells	27
Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein	27
ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells	27
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	27
Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells	27
Selective autophagy regulates chloroplast protein import and promotes plant stress tolerance	27
The sun, cholesterol and Orai1 conspire in melanoma	27
The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs	27
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	26
Discrete RNA–DNA hybrid cleavage by the EXD2 exonuclease pinpoints two rate‐limiting steps	26
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	26
Cryo‐EM reveals the complex architecture of dynactin's shoulder region and pointed end	26
Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction withAPP	26
The Hda1 histone deacetylase limits divergent non‐coding transcription and restricts transcription initiation frequency	26
Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration	26
m 6 A modification of HSATIII lncRNAs regulates temperature‐dependent splicing	26
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	26
The multi‐scale architecture of mammalian sperm flagella and implications for ciliary motility	26
Structural mechanism of CRL4‐instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor	26
The MASTL/PP2A cell cycle kinase‐phosphatase module restrains PI3K‐Akt activity in an mTORC1‐dependent manner	25
Nucleome programming is required for the foundation of totipotency in mammalian germline development	25
Biogenesis of secretory immunoglobulin M requires intermediate non‐native disulfide bonds and engagement of the protein disulfide isomerase ERp44	25
An ERAD‐independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis	25
Structure and functional mapping of the KRAB‐KAP1 repressor complex	25
Cell line authentication: a necessity for reproducible biomedical research	25
CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system	25
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	25
Hematopoietic stem cells undergo a lymphoid to myeloid switch in early stages of emergency granulopoiesis	25
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange	25
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	25
TOC1 clock protein phosphorylation controls complex formation with NF‐YB/C to repress hypocotyl growth	24
A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins	24
USP33 deubiquitinates and stabilizes HIF‐2alpha to promote hypoxia response in glioma stem cells	24
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	24
Pioneer activity distinguishes activating from non‐activating SOX2 binding sites	24
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila	24
A regulatory phosphorylation site on Mec1 controls chromatin occupancy of RNA polymerases during replication stress	24
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	24
Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab1	24
Mammalian antiviral RNAi is on the move	24
Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b	24
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	23
Presynaptic targeting of botulinum neurotoxin type A requires a tripartitePSG‐Syt1‐SV2plasma membrane nanocluster for synaptic vesicle entry	23
A non‐proteolytic release mechanism for HMCES‐DNA‐protein crosslinks	23
SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation	23
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation	23
DASH/Dam1 complex mutants stabilize ploidy in histone‐humanized yeast by weakening kinetochore‐microtubule attachments	23
CircPVT1 promotes ER‐positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS	23
Pathogenic ACVR1R206H activation by Activin A‐induced receptor clustering and autophosphorylation	22
Barley GRIK1‐SnRK1 kinases subvert a viral virulence protein to upregulate antiviral RNAi and inhibit infection	22
Schwann cell precursors represent a neural crest‐like state with biased multipotency	22
The TBC1D31/praja2 complex controls primary ciliogenesis through PKA‐directed OFD1 ubiquitylation	22
HNRNPH1 regulates the neuroprotective cold‐shock protein RBM3 expression through poison exon exclusion	22
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools	22
Extracellular vesicles and co‐isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells	22
STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons	21
Intramembrane client recognition potentiates the chaperone functions of calnexin	21
Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression	21
Jacob‐induced transcriptional inactivation of CREB promotes Aβ‐induced synapse loss in Alzheimer's disease	21
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	21
N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation	21
Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption	21
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress‐induced damaged mitochondrial DNA	21
Cancer‐associated POT1 mutations lead to telomere elongation without induction of a DNA damage response	21
Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome	21
Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns	21
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	20
CDK11 requires a critical activator SAP30BP to regulate pre‐mRNA splicing	20
Complete suppression of Htt fibrillization and disaggregation of Htt fibrils by a trimeric chaperone complex	20
Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane	20
Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3‐Lgr4 axis	20
A tale of two Hippo pathway modules	20
The CRL4 DCAF1 cullin‐RING ubiquitin ligase is activated following a switch in oligomerization state	20
Glycolysis regulates Hedgehog signalling via the plasma membrane potential	20
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	20
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway	20
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks	20
Autophagy‐linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS‐CoV‐2 entry into human cells	20
BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis	20
Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein	20
Deciphering functional tumor states at single‐cell resolution	20
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	19
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin	19
Chromatin remodeling is required for sRNA‐guided DNA elimination in Paramecium	19
Nicotinamide N‐methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer	19
Inactive variants of death receptor p75 NTR reduce Alzheimer’s neuropathology by interfering with APP internalization	19
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	19
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	19
Phospho‐regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore	19