EMBO Journal

Article	Citations
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	189
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	175
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	175
The plant noncoding transcriptome: a versatile environmental sensor	156
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	127
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	122
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	120
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	117
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	116
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	115
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	113
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	112
In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	110
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	98
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	97
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	94
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1‐SV2 plasma membrane nanocluster for synaptic vesicle entry	92
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	92
Evolutionary adaptation of the protein folding pathway for secretability	88
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori	87
Eating your mitochondria—when too much of a good thing turns bad	86
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	86
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	83
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking GTPase activity	82
Interferon‐inducible phospholipids govern IFITM3‐dependent endosomal antiviral immunity	80

Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break formation	80
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation	79
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	78
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	78
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	78
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	76
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression	75
Ribosome biogenesis factors—from names to functions	74
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	72
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	71
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	70
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	70
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	69
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	69
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	66
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3‐mediated plant senescence pathway	66
The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80	65
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	64
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	64
Erratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	63
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	63
Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila	63
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	62
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	62
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	61
Stress‐dependent macromolecular crowding in the mitochondrial matrix	61
Structure and mechanism of a eukaryotic ceramide synthase complex	61
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	61
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	58
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	57
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	55
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	55
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	54
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis PR gene expression and disease resistance	54
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	53
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	52
LUBAC and NF‐κB trigger a nuclear response from mitochondria	52
Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance	51
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	51
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	50
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	50
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6‐methyladenosine‐containing RNA virus	50
TFEB‐dependent lysosome biogenesis is required for senescence	49
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	49
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	49
Nix interacts with WIPI2 to induce mitophagy	49
A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cells	48
Binary organization of epidermal basal domains highlights robustness to environmental exposure	48
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	48
E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities	47

Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	46
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	46
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	45
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	45
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	45
Mitochondria and peroxisomes are NIXed for clearance	45
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	43
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion	42
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	42
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	42
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	42
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	42
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	42
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	42
Erratum To: Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	41
Hold the fold: how delayed folding aids protein secretion	41
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	41
Quorum sensing componentry opens new lines of communication	41
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	40
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α	40
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	40
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication	39
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding	38
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	38
Two Hippo signaling modules orchestrate liver size and tumorigenesis	38
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	38
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion	37
Fuel oxidation under the control of mitochondrial shape and dynamics	37
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation	37
STAT1 is required to establish but not maintain interferon‐γ‐induced transcriptional memory	37
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases	37
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	37
Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies	37
Erratum To: Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	37
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	37
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr1	36
microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes	36
You can “tail” them apart: paralog‐specific functions of CRL4B ubiquitin ligases during mitosis and brain development	36
Fecal microbiota transplantation enhances cell therapy in a rat model of hypoganglionosis by SCFA‐induced MEK1/2 signaling pathway	36
An accessory prefrontal cortex–thalamus circuit sculpts maternal behavior in virgin female mice	36
Pathogenic fungi neutralize plant‐derived ROS via Srpk1 deacetylation	36
Creativity as an antidote to research becoming too predictable	36
Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome	36
Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress	36
Anti‐hsa‐miR‐59 alleviates premature senescence associated with Hutchinson‐Gilford progeria syndrome in mice	35
Spo13/MEIKIN ensures a Two‐Division meiosis by preventing the activation of APC/CAma1 at meiosis I	35
Sweet‐talk in the time of cholera: host mucin negotiates peace with Vibrio cholerae	35
Host cell egress of Brucella abortus requires BNIP3L‐mediated mitophagy	35
Retromer oligomerization drives SNX‐BAR coat assembly and membrane constriction	34
Recycling of the actin monomer pool limits the lifetime of network turnover	34
LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation	34
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters	34
Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse	33
Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes	33
Cryo‐EM structure of antibacterial efflux transporter QacA from Staphylococcus aureus reveals a novel extracellular loop with allosteric role	33
Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness	33
T‐cell antigen recognition: catch‐as‐catch‐can or catch‐22?	33
Thiol reductive stress activates the hypoxia response pathway	32
Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency	32
High‐throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory‐deprived cortical cholinergic VIP/CHAT neurons	32
Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV‐1 reservoirs for virus dissemination	32
Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding	31
RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart	31
Auxin‐dependent regulation of cell division rates governs root thermomorphogenesis	31
A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans	31
Acetylation coordinates the crosstalk between carbon metabolism and ammonium assimilation in Salmonella enterica	31
Tau target identification reveals NSF‐dependent effects on AMPA receptor trafficking and memory formation	31
Termination of STING responses is mediated via ESCRT‐dependent degradation	31
Regulation of mitochondrial proteostasis by the proton gradient	31
Nucleoporin foci are stress‐sensitive condensates dispensable for C. elegans nuclear pore assembly	31
ARFs get the BioID treatment: what have we been missing?	30
A systematic proximity ligation approach to studying protein‐substrate specificity identifies the substrate spectrum of the Ssh1 translocon	30
The adaptive strategies of cells in the face of CIN	30
Erratum To: Two Hippo signaling modules orchestrate liver size and tumorigenesis	30
NME6: ribonucleotide salvage sustains mitochondrial transcription	30
Making liver cancer cells go ARGh!	30
The ASC‐1 complex promotes translation initiation by scanning ribosomes	29
Condensin pinches a short negatively supercoiled DNA loop during each round of ATP usage	29
Role of PCIF1‐mediated 5′‐cap N6‐methyladeonsine mRNA methylation in colorectal cancer and anti‐PD‐1 immunotherapy	29
Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure	29

Macrophage‐derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection	29
Nucleic acid–protein condensates in innate immune signaling	29
m6A is required for resolving progenitor identity during planarian stem cell differentiation	29
The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target	29
Promoter‐pervasive transcription causes RNA polymerase II pausing to boost DOG1 expression in response to salt	29
Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2	29
Adaptive pathfinding by nucleokinesis during amoeboid migration	29
Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression	29
Suppression of Ca2+ signaling enhances melanoma progression	28
Extracellular vesicles and co‐isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells	28
Structure and functional mapping of the KRAB‐KAP1 repressor complex	28
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	28
Nicotinamide N‐methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer	27
ER exit sites take the strain	27
Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the ubiquitin‐proteasome system	27
Erratum To: Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway	27
Actin network architecture can ensure robust centering or sensitive decentering of the centrosome	27
A Zn‐dependent structural transition of SOD1 modulates its ability to undergo phase separation	27
A tale of two Hippo pathway modules	27
The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs	27
The MASTL/PP2A cell cycle kinase‐phosphatase module restrains PI3K‐Akt activity in an mTORC1‐dependent manner	27
AATF/Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma	26
Chromatin remodeling is required for sRNA‐guided DNA elimination in Paramecium	26
Phosphorylation controls spatial and temporal activities of motor‐PRC1 complexes to complete mitosis	26
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation	26
Barley GRIK1‐SnRK1 kinases subvert a viral virulence protein to upregulate antiviral RNAi and inhibit infection	26
Epigenetic escape of immunosurveillance by malignant cell precursors	26
Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates	26
Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns	26
Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons	26
Condensate functionalization with microtubule motors directs their nucleation in space and allows manipulating RNA localization	26
Centrosome linker diversity and its function in centrosome clustering and mitotic spindle formation	26
Damage‐induced regeneration of the intestinal stem cell pool through enteroblast mitosis in the Drosophila midgut	26
eIF3 mRNA selectivity profiling reveals eIF3k as a cancer‐relevant regulator of ribosome content	25
Prohibitin 1 regulates mtDNA release and downstream inflammatory responses	25
Adaptation to high rates of chromosomal instability and aneuploidy through multiple pathways in budding yeast	25
TSG101 associates with PARP1 and is essential for PARylation and DNA damage‐induced NF‐κB activation	25
Long noncoding RNA‐mediated epigenetic regulation of auxin‐related genes controls shade avoidance syndrome in Arabidopsis	25
LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates	25
GPNMB+Gal‐3+ hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogenesis	25
Aberrant DNA N6‐methyladenine incorporation via adenylate kinase 1 is suppressed by ADAL deaminase‐dependent 2′‐deoxynucleotide pool sanitation	25
Neil J. Bulleid (1960–2023), a virtuoso of protein folding and redox biology	25
High air humidity dampens salicylic acid pathway and NPR1 function to promote plant disease	25
YAP/BRD4‐controlled ROR1 promotes tumor‐initiating cells and hyperproliferation in pancreatic cancer	25
Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the polar body extrusion pathway	25
Rap1 prevents fusions between long telomeres in fission yeast	25
An ERK1/2‐driven RNA‐binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene	25
A small RNA system ensures accurate homologous pairing and unpaired silencing of meiotic chromosomes	24
WRKY transcription factors and OBERON histone‐binding proteins form complexes to balance plant growth and stress tolerance	24
The notorious R.N.A.	24
A tryptophan metabolite made by a gut microbiome eukaryote induces pro‐inflammatory T cells	24
Gut microbiota regulates blood‐cerebrospinal fluid barrier function and Aβ pathology	24
C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH‐1	24
HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity	24
TOR acts as a metabolic gatekeeper for auxin‐dependent lateral root initiation in Arabidopsis thaliana	23
Structural basis of ubiquitin‐independent PP1 complex disassembly by p97	23
YTHDF2/m6A/NF‐κB axis controls anti‐tumor immunity by regulating intratumoral Tregs	23
Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells	23
BCL11B and the NuRD complex cooperatively guard T‐cell fate and inhibit OPA1‐mediated mitochondrial fusion in T cells	23
RNA‐based medicine: from molecular mechanisms to therapy	23
Phase separation of Hippo signalling complexes	23
Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory	23