EMBO Journal

Article	Citations
Autophagy in major human diseases	605
Molecular mechanisms and physiological functions of mitophagy	543
SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells	500
SARS ‐CoV‐2 targets neurons of 3D human brain organoids	385
Syncytia formation by SARS‐CoV‐2‐infected cells	350
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells	312
m 6 A RNA methylation: from mechanisms to therapeutic potential	310
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2	308
Dynamic EMT: a multi‐tool for tumor progression	288
RNA m 6 A methylation regulates sorafenib resistance in liver cancer through FOXO 3‐mediated autophagy	253
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells	222
m 6 A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy	215
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia	213
Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer	212
Cholesterol 25‐Hydroxylase inhibits SARS ‐CoV‐2 and other coronaviruses by depleting membrane cholesterol	200
SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs	188
Structures of the SARS ‐CoV‐2 nucleocapsid and their perspectives for drug design	183
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast	169
Opposing activities of IFITM proteins in SARS‐CoV‐2 infection	154
An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells	149
Cell death pathways: intricate connections and disease implications	147
SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation	138
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation	134
MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation	123
Cancer evolution: Darwin and beyond	118

Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage	117
LRRK 2 activation controls the repair of damaged endomembranes in macrophages	114
Pore formation in regulated cell death	111
A novel approach to measure mitochondrial respiration in frozen biological samples	109
ATP and cancer immunosurveillance	104
Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions	103
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction	101
On the role of phase separation in the biogenesis of membraneless compartments	101
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner	99
The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants	98
Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP	98
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding	95
CARD8 inflammasome activation triggers pyroptosis in human T cells	94
CALCOCO 1 acts with VAMP ‐associated proteins to mediate ER ‐phagy	85
Ca 2+ signals in plant immunity	82
ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways	82
Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b	79
Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy	79
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition	75
Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment	75
BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis	75
Mechanisms of site‐specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits	75
Translation of small downstream ORFs enhances translation of canonical main open reading frames	74
Cell softness regulates tumorigenicity and stemness of cancer cells	73
SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage	73
FFAT motif phosphorylation controls formation and lipid transfer function of inter‐organelle contacts	73
Sealing holes in cellular membranes	72
Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies	69
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation	68
Highly active rubiscos discovered by systematic interrogation of natural sequence diversity	68
Clock component OsPRR73 positively regulates rice salt tolerance by modulating OsHKT2;1 ‐mediated sodium homeostasis	67
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses	65
Peering into tunneling nanotubes—The path forward	65
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	64
The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking	63
The multifaceted role of autophagy in cancer	62
Fungal‐induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL‐22	62
Structure of a human replisome shows the organisation and interactions of a DNA replication machine	60
Glutamine deprivation alters the origin and function of cancer cell exosomes	60
Flavonol‐mediated stabilization of PIN efflux complexes regulates polar auxin transport	60
Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins	60
Syncytia formation by SARS‐CoV‐2‐infected cells	59
BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡	59
MiT/ TFE factors control ER ‐phagy via transcriptional regulation of FAM 134B	58
DRP1 interacts directly with BAX to induce its activation and apoptosis	57
Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila	57
Roles of plant retinoblastoma protein: cell cycle and beyond	57
Modulation of plant root growth by nitrogen source‐defined regulation of polar auxin transport	57
The multi‐scale architecture of mammalian sperm flagella and implications for ciliary motility	57
Plant immunity suppression via PHR1‐RALF‐FERONIA shapes the root microbiome to alleviate phosphate starvation	56

The extracellular vesicle generation paradox: a bacterial point of view	56
Tollip coordinates Parkin‐dependent trafficking of mitochondrial‐derived vesicles	56
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling	55
Best practices for the visualization, mapping, and manipulation of R‐loops	55
Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis	54
Arabidopsis shoot stem cells display dynamic transcription and DNA methylation patterns	54
Paraspeckles are constructed as block copolymer micelles	54
Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70‐mediated trimer unzipping and dissociation from DNA	54
LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes	54
HOIL‐1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation	52
PIF1 helicase promotes break‐induced replication in mammalian cells	52
Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes	52
Disrupting HIV ‐1 capsid formation causes cGAS sensing of viral DNA	52
The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species	51
Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease	51
Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B	51
Nox4 regulates InsP 3 receptor‐dependent Ca 2+ release into mitochondria to promote cell survival	50
NAADP ‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca 2+ nanodomains, calcineurin and dynamin	50
Timeless couples G‐quadruplex detection with processing by DDX 11 helicase during DNA replication	49
An optimized quantitative proteomics method establishes the cell type‐resolved mouse brain secretome	49
NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients	49
HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations	49
Structural insights into actin filament recognition by commonly used cellular actin markers	49
Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria	49
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration	48
Cell competition in intratumoral and tumor microenvironment interactions	47
The cold response regulator CBF1 promotes Arabidopsis hypocotyl growth at ambient temperatures	47
CompromisedDNArepair is responsible for diabetes‐associated fibrosis	47
Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans	46
Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF	46
CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawal	45
Structural basis of Focal Adhesion Kinase activation on lipid membranes	45
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection	45
Clustering and reverse transcription of HIV‐1 genomes in nuclear niches of macrophages	45
Deciphering the regulatory landscape of fetal and adult γδ T‐cell development at single‐cell resolution	45
Golgi maturation‐dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3	45
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity	44
Identification and characterization of diverse OTU deubiquitinases in bacteria	44
MSH 2 shapes the meiotic crossover landscape in relation to interhomolog polymorphism in Arabidopsis	44
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin	43
Microglial MERTK eliminates phosphatidylserine‐displaying inhibitory post‐synapses	42
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress‐induced damaged mitochondrial DNA	42
Multilineage murine stem cells generate complex organoids to model distal lung development and disease	42
A sensory cell diversifies its output by varying Ca 2+ influx‐release coupling among active zones	42
5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING	42
Long‐term expansion with germline potential of human primordial germ cell‐like cells in vitro	42
Single‐cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin‐driven circadian network	41
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration	41
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair	41
Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction	41
Microtubules control nuclear shape and gene expression during early stages of hematopoietic differentiation	41
Centrosome defects cause microcephaly by activating the 53BP1‐USP28‐TP53 mitotic surveillance pathway	40
Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology	40
Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks	39
BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites	39
Identification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sites	38
Expression of human‐specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility	38
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	38
Plant E3 ligases SNIPER 1 and SNIPER 2 broadly regulate the homeostasis of sensor NLR immune re	38
Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26	38
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks	38
Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants	38
A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium	38
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response	37
Activation of endogenous retroviruses during brain development causes an inflammatory response	37
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis	37
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency	37
Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis	37
SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice	36
m 6 A modification of HSATIII lncRNAs regulates temperature‐dependent splicing	36
Regulation of mitochondrial proteostasis by the proton gradient	36
Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system	36
Non‐canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus	36
BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis	36
Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy	35
Rewired signaling network in T cells expressing the chimeric antigen receptor ( CAR )	35
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component	35
Cryo‐EM structure of the CENP‐A nucleosome in complex with phosphorylated CENP‐C	35
ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation	35
A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐8	35

Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV‐1 infection	35
Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates	35
Nuclear cGAS: guard or prisoner?	35
Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit	35
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification	34
Munc13 activates the Munc18‐1/syntaxin‐1 complex and enables Munc18‐1 to prime SNARE assembly	34
A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes	34
Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway	34
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr1	34
Structural insights into mammalian mitochondrial translation elongation catalyzed by mt EFG 1	33
Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2	33
Self‐assembly of multi‐component mitochondrial nucleoids via phase separation	33
SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation	33
LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy	33
RNA localization and co‐translational interactions control RAB 13 GTP ase function and cell migration	33
Cellular stress promotes NOD1/2‐dependent inflammation via the endogenous metabolite sphingosine‐1‐phosphate	33
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity	33
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange	33
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models	32
Transcriptional repression of NFKBIA triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence	32
Protein structure, amino acid composition and sequence determine proteome vulnerability to oxidation‐induced damage	32
Programmable C‐to‐U RNA editing using the human APOBEC 3A deaminase	32
Open conformation of tetraspanins shapes interaction partner networks on cell membranes	31
Extracellular vesicles and particles impact the systemic landscape of cancer	31
Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features	31
HASTY , the Arabidopsis EXPORTIN5 ortholog, regulates cell‐to‐cell and vascular microRNA movement	31
EGFR ‐mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions	31
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation	31
RNF 43 truncations trap CK 1 to drive niche‐independent self‐renewal in cancer	31
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome	31
Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway	31
Dysfunctional oxidative phosphorylation shunts branched‐chain amino acid catabolism onto lipogenesis in skeletal muscle	31
Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues	31
Selective cross‐linking of coinciding protein assemblies by in‐gel cross‐linking mass spectrometry	31
Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis	31
Architecture of the centriole cartwheel‐containing region revealed by cryo‐electron tomography	30
Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding	30
Unraveling the features of somatic transposition in the Drosophila intestine	30
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis	30
Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency	30
Structural basis for loading and inhibition of a bacterial T6 SS phospholipase effector by the VgrG spike	30
Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration	30
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens	30
Adjustment of the PIF7‐HFR1 transcriptional module activity controls plant shade adaptation	30
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools	30
Photoreceptor nanotubes mediate the in vivo exchange of intracellular material	30
Human shelterin protein POT 1 prevents severe telomere instability induced by homology‐directed DNA repair	29
ADP‐ribosylation of histone variant H2AX promotes base excision repair	29
Cryo‐EM structure of native human uromodulin, a zona pellucida module polymer	29
N 6 ‐methyladenosine modification of lncRNA Pvt1 governs epidermal stemness	29
m 6 A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region	29
A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies	29
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA	29
A comparative analysis of the mobility of 45 proteins in the synaptic bouton	29
Reproducible image handling and analysis	29
Polarized sorting of Patched enables cytoneme‐mediated Hedgehog reception in the Drosophila wing disc	28
RNA is required for the integrity of multiple nuclear and cytoplasmic membrane‐less RNP granules	28
Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress	28
Involvement of circulating factors in the transmission of paternal experiences through the germline	28
N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation	28
Toxoplasma GRA 15 limits parasite growth in IFN γ‐activated fibroblasts through TRAF ubi	28
Architecture of the active post‐translational Sec translocon	28
CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos	28
Schwann cell precursors represent a neural crest‐like state with biased multipotency	28
IFT54 directly interacts with kinesin‐II and IFT dynein to regulate anterograde intraflagellar transport	27
Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption	27
Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification	27
Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex	27
Histone chaperone CAF‐1 promotes HIV‐1 latency by leading the formation of phase‐separated suppressive nuclear bodies	27
SEUSS integrates transcriptional and epigenetic control of root stem cell organizer specification	27
Tyr‐Asp inhibition of glyceraldehyde 3‐phosphate dehydrogenase affects plant redox metabolism	27
RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency	26
Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency	26
Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab1	26
Rabl2 GTP hydrolysis licenses BBSome‐mediated export to fine‐tune ciliary signaling	26
Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis	26
Endothelium‐derived lactate is required for pericyte function and blood–brain barrier maintenance	26
The structure of the MICU 1‐ MICU 2 complex unveils the regulation of the mitochondrial calcium uniporter	26
Ribosome slowdown triggers codon‐mediated mRNA decay independently of ribosome quality control	25
ZDHHC18 negatively regulates cGAS‐mediated innate immunity through palmitoylation	25
The C‐degron pathway eliminates mislocalized proteins and products of deubiquitinating enzymes	25
Dynamic properties of noise and Her6 levels are optimized by miR‐9, allowing the decoding of the Her6 oscillator	25
IFN‐β rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1	25
Nucleo‐plastidic PAP 8/ pTAC 6 couples chloroplast formation with photomorphogenesis	25
Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells	25
GRASP55 regulates intra‐Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis	25
A genetic memory initiates the epigenetic loop necessary to preserve centromere position	25
m6A‐mediated alternative splicing coupled with nonsense‐mediated mRNA decay regulates SAM synthetase homeostasis	25
Dermal αSMA + myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production	25
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	25
BNIP3L/NIX regulates both mitophagy and pexophagy	25
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism‐like phenotype	25
Barley stripe mosaic virus γb protein disrupts chloroplast antioxidant defenses to optimize viral replication	25
Chromosomal instability by mutations in the novel minor spliceosome component CENATAC	25
Helical ordering of envelope‐associated proteins and glycoproteins in respiratory syncytial virus	25