OOIR: Observatory of International Research

Papers

(The TQCC of Atla-Alternatives to Laboratory Animals is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model	61
Spotlight on Three Rs Progress	36
Spotlight on Three Rs Progress	33
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC-MS/MS Analysis	30
The Use of Human Tissues for Research: What Investigators Need to Know	27
Conference Diary	26
Resources Round-up	23
Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis	21
The Development of an Animal Product-free, Precision-cut Lung Slice Cryopreservation and Post-thaw Culture Method	20
Progress and Remaining Opportunities to Increase the Use of Animal-free Antibodies in the USA	15
The Rise of Three Rs Centres and Platforms in Europe*	13
A History of the Development of Alternatives to Animals in Research and Testing	11
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022	10
Conference Diary	10
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders	10
Editorial	9
Development of Sensitive In Vitro Protocols for the Biocompatibility Testing of Medical Devices and Pharmaceuticals Intended for Contact with the Eyes: Acute Irritation and Phototoxicity Assess	9
Spotlight on Three Rs Progress	8
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with La	8
Resources Round-up	8
Reviewing Current Guidance for the ‘R’ of Replacement and Rethinking it with the ‘Replacement Checklist’	7
Editorial	7
The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	7
Editorial	7
2021 Michael Balls Award	7

Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs	6
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	6
A Cytotoxicity Assay as an Alternative to the Murine Model for the Potency Testing of Bothrops jararaca Venom and Antivenom: An Intralaboratory Pre-validation Study	6
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	6
Editorial	5
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes	5
Thanks to Reviewers	5
Editorial	5
Corrigendum to Case Studies Exemplifying the Transition to Animal Component-Free Cell Culture	4
Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells	4
Editorial	4
JRC Summer School 2021	4
Resources Round-up	4
Editorial	4
Editorial	4
A New ATLA Associate Editor	3
Accelerating Animal Replacement: How Universities Can Lead — Results of a One-Day Expert Workshop in Zurich, Switzerland	3
Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	3
Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)	3
The Development and Evaluation of Brain and Heart Cell Lines from a Marine Fish for Use in Xenobiotic-Induced Cytotoxicity Testing	3
Lessons for the Future of NAMs from History, Philosophy and Social Studies of Science	3
Conference Diary	3
Editorial	3
Spotlight on Three Rs Progress	3
The Current Status and Work of Three Rs Centres and Platforms in Europe*	3
Spotlight on Three Rs Progress	3
Editorial	3
The Evolution of Regulatory Toxicology: Where is the Gardener?	2
The Use of 3-D Models of Echocardiographic Imaging Planes for Teaching Echocardiography Techniques for Use in Dogs and Cats	2
Spotlight on Three Rs Progress	2
The Use of Artificial Intelligence for the Fast and Effective Identification of Three Rs-based Literature	2
Journeying Through Journals: The Publishing Process and How to Maximise Research Impact	2
Resources Round-up	2
Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids	2
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	2
Resources Round-up	2
ATLA Best Poster Award	2
Conference Diary	2
An Evaluation of the Replacement of Animal-derived Biomaterials in Human Primary Cell Culture	2
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021	2
Use of the Allium cepa Model to Assess the Cytogenotoxicity of Luffariella herdmani Marine Sponge Extract	2
Editorial	2
Transparency in Non-Technical Project Summaries to Promote the Three Rs in Respiratory Disease Research	2