OOIR: Observatory of International Research

Papers

(The TQCC of Atla-Alternatives to Laboratory Animals is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model	107
Spotlight on Three Rs Progress	39
Spotlight on Three Rs Progress	38
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC-MS/MS Analysis	32
The Use of Human Tissues for Research: What Investigators Need to Know	23
Conference Diary	23
The Development of an Animal Product-free, Precision-cut Lung Slice Cryopreservation and Post-thaw Culture Method	16
Resources Round-up	15
Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis	15
Combinatorial induction with valproic acid and fibroblast growth factor-9 enhances neural differentiation and cell fate commitment in adipose tissue-derived mesenchymal stem cells	15
Editorial	12
The Rise of Three Rs Centres and Platforms in Europe*	11
A History of the Development of Alternatives to Animals in Research and Testing	10
Conference Diary	10
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders	10
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022	9
Development of Sensitive In Vitro Protocols for the Biocompatibility Testing of Medical Devices and Pharmaceuticals Intended for Contact with the Eyes: Acute Irritation and Phototoxicity Assess	9
Editorial	9
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with La	9
Progress and Remaining Opportunities to Increase the Use of Animal-free Antibodies in the USA	9
Resources Round-up	8
Editorial	7
Dr Manfred Liebsch: Former Head of ZEBET and ATLA Editorial Board Member	7
Editorial	7
Spotlight on Three Rs Progress	7

The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	6
2021 Michael Balls Award	6
Resources Round-up	5
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	5
Thanks to Reviewers	5
Reviewing Current Guidance for the ‘R’ of Replacement and Rethinking it with the ‘Replacement Checklist’	5
Editorial	5
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	5
A Cytotoxicity Assay as an Alternative to the Murine Model for the Potency Testing of Bothrops jararaca Venom and Antivenom: An Intralaboratory Pre-validation Study	5
Editorial	4
Editorial	4
Editorial	4
Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells	4
Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	4
Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs	4
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes	4
Book Review: Lab dog: A beagle and his human investigate the surprising world of animal research Melanie D.G. Kaplan (2025). Lab Dog: A Beagle and His Human Investigate the Surprising World of Animal	4
Spotlight on Three Rs Progress	4
Corrigendum to Case Studies Exemplifying the Transition to Animal Component-Free Cell Culture	4
Resources Round-up	4
Editorial	3
Editorial	3
Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)	3
The Use of 3-D Models of Echocardiographic Imaging Planes for Teaching Echocardiography Techniques for Use in Dogs and Cats	3
Lessons for the Future of NAMs from History, Philosophy and Social Studies of Science	3
Accelerating Animal Replacement: How Universities Can Lead — Results of a One-Day Expert Workshop in Zurich, Switzerland	3
Conference Diary	3
Editorial	3
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	3
Spotlight on Three Rs Progress	3
A New ATLA Associate Editor	3
Spotlight on Three Rs Progress	3
Determining the pathogenicity of uropathogenic Escherichia coli strains in the Galleria mellonella larvae model	3
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021	3
The Current Status and Work of Three Rs Centres and Platforms in Europe*	3