OOIR: Observatory of International Research

Papers

(The TQCC of Atla-Alternatives to Laboratory Animals is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC	154
Spotlight on Three Rs Progress	46
Spotlight on Three Rs Progress	38
The Use of Human Tissues for Research: What Investigators Need to Know	26
The Development of an Animal Product-free, Precision-cut Lung Slice Cryopreservation and Post-thaw Culture Method	19
Conference Diary	18
Combinatorial induction with valproic acid and fibroblast growth factor-9 enhances neural differentiation and cell fate commitment in adipose tissue-derived mesenchymal stem cells	17
Evaluation of the antinociceptive effects of gabapentin using Gromphadorhina portentosa as a non-vertebrate in vivo	16
Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis	16
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022	13
Development of Sensitive In Vitro Protocols for the Biocompatibility Testing of Medical Devices and Pharmaceuticals Intended for Contact with the Eyes: A	12
A History of the Development of Alternatives to Animals in Research and Testing	11
Conference Diary	11
Progress and Remaining Opportunities to Increase the Use of Animal-free Antibodies in the USA	11
Resources Round-up	10
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders	10
Resources Round-up	9
Editorial	9
Dr Manfred Liebsch: Former Head of ZEBET and ATLA Editorial Board Member	9
Editorial	9
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and	9
Reviewing Current Guidance for the ‘R’ of Replacement and Rethinking it with the ‘Replacement Checklist’	8
The impossible made possible through the use of New Approach Methodologies: Dermal safety assessment of potential insect repellent or insecticidal active ingredients using a high-throughput approach t	8
Editorial	7
Resources Round-up	7

2021 Michael Balls Award	7
The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	6
Editorial	6
Thanks to Reviewers	6
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	6
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	6
Spotlight on Three Rs Progress	6
A Cytotoxicity Assay as an Alternative to the Murine Model for the Potency Testing of Bothrops jararaca Venom and Antivenom: An Intralaboratory Pre-valid	5
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes	5
Book Review: Lab dog: A beagle and his human investigate the surprising world of animal research Melanie D.G. Kaplan (2025). Lab Dog: A Beagle and His Human Investigate the Surprising World of Animal	5
Synthetic substrates as alternatives to bovine enamel in restorative dental materials research — A review	5
Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs	5
Editorial	5
Editorial	5
Spotlight on Three Rs Progress	5
Corrigendum to Case Studies Exemplifying the Transition to Animal Component-Free Cell Culture	5
Resources Round-up	4
Spotlight on Three Rs Progress	4
Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	4
Editorial	4
Editorial	4
Determining the pathogenicity of uropathogenic Escherichia coli strains in the Galleria mellonella larvae	4
Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells	4
Human NT2/D1-derived early neural progenitor cells immobilised in alginate microfibres as an in vitro 3D system for neurotoxicity testing	4
The Current Status and Work of Three Rs Centres and Platforms in Europe*	4
Accelerating Animal Replacement: How Universities Can Lead — Results of a One-Day Expert Workshop in Zurich, Switzerland	4
Editorial	4
The Use of 3-D Models of Echocardiographic Imaging Planes for Teaching Echocardiography Techniques for Use in Dogs and Cats	3
Use of the Allium cepa Model to Assess the Cytogenotoxicity of Luffariella herdmani Marine Sponge Extract	3
Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)	3
Conference Diary	3
Transparency in Non-Technical Project Summaries to Promote the Three Rs in Respiratory Disease Research	3
Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids	3
Editorial	3
Editorial	3
Resources Round-up	3
Spotlight on Three Rs Progress	3
Lessons for the Future of NAMs from History, Philosophy and Social Studies of Science	3
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	3