OOIR: Observatory of International Research

Papers

(The TQCC of Atla-Alternatives to Laboratory Animals is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model	102
Spotlight on Three Rs Progress	37
Spotlight on Three Rs Progress	36
The Use of Human Tissues for Research: What Investigators Need to Know	31
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC-MS/MS Analysis	23
Conference Diary	22
Combinatorial induction with valproic acid and fibroblast growth factor-9 enhances neural differentiation and cell fate commitment in adipose tissue-derived mesenchymal stem cells	16
The Development of an Animal Product-free, Precision-cut Lung Slice Cryopreservation and Post-thaw Culture Method	14
Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis	14
Progress and Remaining Opportunities to Increase the Use of Animal-free Antibodies in the USA	13
Resources Round-up	11
Dr Manfred Liebsch: Former Head of ZEBET and ATLA Editorial Board Member	10
Resources Round-up	10
Conference Diary	9
Development of Sensitive In Vitro Protocols for the Biocompatibility Testing of Medical Devices and Pharmaceuticals Intended for Contact with the Eyes: Acute Irritation and Phototoxicity Assess	9
Editorial	9
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders	9
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022	9
A History of the Development of Alternatives to Animals in Research and Testing	9
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with La	8
Spotlight on Three Rs Progress	7
Editorial	7
The Rise of Three Rs Centres and Platforms in Europe*	7
Editorial	6
Editorial	6

2021 Michael Balls Award	6
The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	6
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	5
Thanks to Reviewers	5
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	5
A Cytotoxicity Assay as an Alternative to the Murine Model for the Potency Testing of Bothrops jararaca Venom and Antivenom: An Intralaboratory Pre-validation Study	5
Reviewing Current Guidance for the ‘R’ of Replacement and Rethinking it with the ‘Replacement Checklist’	5
Editorial	5
Corrigendum to Case Studies Exemplifying the Transition to Animal Component-Free Cell Culture	4
Book Review: Lab dog: A beagle and his human investigate the surprising world of animal research Melanie D.G. Kaplan (2025). Lab Dog: A Beagle and His Human Investigate the Surprising World of Animal	4
Resources Round-up	4
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes	4
Editorial	4
Spotlight on Three Rs Progress	4
Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs	4
Editorial	4
Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells	4
Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	3
A New ATLA Associate Editor	3
Editorial	3
Determining the pathogenicity of uropathogenic Escherichia coli strains in the Galleria mellonella larvae model	3
Spotlight on Three Rs Progress	3
Editorial	3
Editorial	3
Conference Diary	3
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	3
The Use of 3-D Models of Echocardiographic Imaging Planes for Teaching Echocardiography Techniques for Use in Dogs and Cats	3
Editorial	3
Accelerating Animal Replacement: How Universities Can Lead — Results of a One-Day Expert Workshop in Zurich, Switzerland	3
JRC Summer School 2021	3
Lessons for the Future of NAMs from History, Philosophy and Social Studies of Science	3
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021	3
Transparency in Non-Technical Project Summaries to Promote the Three Rs in Respiratory Disease Research	2
ATLA Best Poster Award	2
Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)	2
Use of the Allium cepa Model to Assess the Cytogenotoxicity of Luffariella herdmani Marine Sponge Extract	2
An Evaluation of the Replacement of Animal-derived Biomaterials in Human Primary Cell Culture	2
Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids	2
Spotlight on Three Rs Progress	2
Resources Round-up	2
Editorial	2
The Current Status and Work of Three Rs Centres and Platforms in Europe*	2
Resources Round-up	2