Atla-Alternatives to Laboratory Animals

Article	Citations
Poor Translatability of Biomedical Research Using Animals — A Narrative Review	31
Upholding the EU's Commitment to ‘Animal Testing as a Last Resort' Under REACH Requires a Paradigm Shift in How We Assess Chemical Safety to Close the Gap Between Regulatory Testing and Modern Safety	29
Curated Data In — Trustworthy In Silico Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing	27
A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage	25
The Use of Simulators for Teaching Practical Clinical Skills to Veterinary Students — A Review	22
A History of Regulatory Animal Testing: What Can We Learn?	20
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with La	20
The Rise of Three Rs Centres and Platforms in Europe*	18
The VEGAHUB Platform: The Philosophy and the Tools	16
Prediction of Human Lethal Doses and Concentrations of MEIC Chemicals from Rodent LD50 Values: An Attempt to Make Some Reparation	15
The Use of In Silico Tools for the Toxicity Prediction of Potential Inhibitors of SARS-CoV-2	12
The Current Status and Work of Three Rs Centres and Platforms in Europe*	9
The Evolution of Regulatory Toxicology: Where is the Gardener?	9
Alternatives to Laboratory Animals: Trends in Replacement and the Three Rs	9
Development of an Accessible Gene Expression Bioinformatics Pipeline to Study Driver Mutations of Colorectal Cancer	8
Comparison of Long-term Human Precision-cut Lung Slice Culture Methodology and Response to Challenge: An Argument for Standardisation	8
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022	7
It’s Time to Include Harm to Humans in Harm–Benefit Analysis — But How to Do It, That is the Question	7
Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters	7
Biobank Personnel — The Key to its Success	6
Ex Vivo Human Skin: An Alternative Test System for Skin Irritation and Corrosion Assays	6
The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	6
Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings	6
The Use of Artificial Intelligence for the Fast and Effective Identification of Three Rs-based Literature	5
The Effects of Urolithin B and Auraptene on Quinolinic Acid-induced Toxicity in the SH-SY5Y Neuroblastoma Cell Line	5

Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	5
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	5
The Use of Human Tissues for Research: What Investigators Need to Know	5
Development of an In Vitro Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells	5
Coculture of ARPE-19 Cells and Porcine Neural Retina as an Ex Vivo Retinal Model	5
A Comparison of Mesenchymal Stem Cell-derived Hepatocyte-like Cells and HepG2 Cells for Use in Drug-Induced Liver Injury Studies	4
Biomedical Research Must Change — But a Shift Toward Human-specific Research Methods Is Only Part of What Is Needed	4
Barriers to the Use of Recombinant Bacterial Endotoxins Test Methods in Parenteral Drug, Vaccine and Device Safety Testing	4
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021	4
An Evaluation of Different Types of Peptone as Partial Substitutes for Animal-derived Serum in Vero Cell Culture	4
It’s Time to Review the Three Rs, to Make them More Fit for Purpose in the 21st Century	3
The Accomplishments of KoCVAM in the Development and Implementation of Alternative Methods in Korea	3
A Short History of the Consideration of Sex Differences in Biomedical Research — Lessons for the In Vitro Community from Animal Models and Human Clinical Trials	3
Cardiac Transcription Regulators Differentiate Human Umbilical Cord Mesenchymal Stem Cells into Cardiac Cells	3
Optimisation of Conditions for the Formation of Spheroids of Head and Neck Squamous Cell Carcinoma Cell Lines for Use as Animal Alternatives	3
The Use of 3-D Models of Echocardiographic Imaging Planes for Teaching Echocardiography Techniques for Use in Dogs and Cats	3
Biomedical Research on Substances of Abuse: The Italian Case Study	3
The In Vitro Evaluation of Preosteoblast Migration From 3-D-printed Scaffolds to Decontaminated Smooth and Minimally Rough Titanium Surfaces: A Pilot Study	3
Culture of Care Enhancement in Egypt: The Impact of Laboratory Animal Science Training on Participants’ Attitudes	3
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders	2
A Low-fidelity Simulator for the Development of Vascular Ligation Skills	2
In Vitro Dengue Virus Inhibition by Aqueous Extracts of Aegle marmelos, Munronia pinnata and Psidium guajava	2
The Capability Maturity Model as a Measure of Culture of Care in Laboratory Animal Science	2
Qualitative and Quantitative Analysis of Certain Aspects of the Cytotoxic and Genotoxic Hazard of Hospital Wastewaters by Using a Range of In Vitro Assays	2
Use of the Allium cepa Model to Assess the Cytogenotoxicity of Luffariella herdmani Marine Sponge Extract	2
EURL ECVAM Activities	2
Towards More Human and Humane Testing: The Role of the Device Supplier Industry	2
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model	2
The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods	2
A Cytotoxicity Assay as an Alternative to the Murine Model for the Potency Testing of Bothrops jararaca Venom and Antivenom: An Intralaboratory Pre-validation Study	2
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	2
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	2
Adapting to Changes in Publishing When Searching for Alternatives and Reporting on Animal Research: A Librarian’s Perspective	2
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC-MS/MS Analysis	2
Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance	2
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes	2
Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids	2
The Use of In Silico Methods to Identify and Assess Antigenic Regions Suitable for the Development of Peptide-based Pan-viral Vaccines	1
Transparency in Non-Technical Project Summaries to Promote the Three Rs in Respiratory Disease Research	1
Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health	1
Chitosan–Calcium Aluminate as a Cell-homing Scaffold: Its Bioactivity Testing in a Microphysiological Dental Pulp Platform	1
A Novel Ex Vivo Blinking Method for Comparing the Corneal Residence Time of New Shampoo Formulations	1
Is UK Animal Research Governance Facing a ‘New Normal’? Considering the Risks and Benefits of ‘Going Online’	1
In Silico Prediction of Eye Irritation Using Hansen Solubility Parameters and Predicted pKa Values	1
Evaluating the Protective Effects of Thymoquinone on Methamphetamine-induced Toxicity in an In Vitro Model Based on Differentiated PC12 Cells	1
Determination of the Microinjected Cytosolic Concentration by Using Mathematical Models of Fluid Dynamics	1
Zebrafish Beyond the Bench: The ‘Plataforma Zebrafish Open Doors’ Programme	1
How to Foster ‘New Approach Methodology’ Toxicologists	1
The Perceptions of Students and Lecturers on the Use of Animals in Biomedical Science Undergraduate Education in Brazil	1
Key Challenges for In Vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for the In Vitro Mouse Lymphoma Assay	1

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis	1
Editorial	1
A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study	1
Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells	1
Acute Toxicity Assays with the Artemia salina Model: Assessment of Variables	1
Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs	1
Educators’ Views on the Use of Dissection and Dissection Alternatives in American Biology Classrooms	1
Evaluation of a Low-cost Renal Simulator for the Diagnostic Ultrasound Training of Veterinary Medicine Students	1
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022	1
The Development and Evaluation of Brain and Heart Cell Lines from a Marine Fish for Use in Xenobiotic-Induced Cytotoxicity Testing	1
Academic Training to Promote the Implementation of Alternative Methods and the Three Rs in the Field of Toxicology	1
An Accessible Nephrectomy and Cystotomy Simulator for Use in Teaching Small Animal Surgery	1
In Silico Phototoxicity Prediction of Drugs and Chemicals by using Derek Nexus and QSAR Toolbox	1
Editorial	0
Book Review: Zebrafish Model for Biomedical Research	0
Resources Round-up	0
Conference Diary	0
Conference Diary	0
Spotlight on Three Rs Progress	0
Dr Robert Combes (1946–2021)	0
JRC Summer School on Non-animal Approaches in Science, May 2021	0
Thanks to Reviewers	0
Calling all students and early-career researchers — Join us for the second Summer School on Innovative Approaches in Science!	0
A History of the Development of Alternatives to Animals in Research and Testing	0
Resources Round-up	0
Resources Round-up	0
Resources Round-up	0
Editorial	0
Editorial	0
Editorial	0
Lessons for the Future of NAMs from History, Philosophy and Social Studies of Science	0
Resources Round-up	0
Resources Round-up	0
2020 Michael Balls Award	0
Editorial	0
Spotlight on Three Rs Progress	0
2022 Michael Balls Award	0
Spotlight on Three Rs Progress	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Resources Round-up	0
Cigarette Smoke Constituents and Nicotine Differentially Affect Cytokine Production by Human Macrophages Stimulated by TLR Ligands In Vitro: Considerations for a Standardised Protocol	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Editorial	0
Spotlight on Three Rs Progress	0
Editorial	0
Assessment of a Low-cost Canine Uterine Simulator as a Tool for Teaching the Ovariohysterectomy Technique to Veterinary Students	0
Thanks to Reviewers	0
Editorial	0
A History of the Development of Alternatives to Animals in Research and Testing	0
Editorial	0
Resources Round-up	0
A New ATLA Associate Editor	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Conference Diary	0
Resources Round-up	0
Resources Round-up	0
Rethinking the Three Rs: Growing Momentum Toward a New Gold Standard in Australian Research	0
Poster Prizes 2021	0
Spotlight on Three Rs Progress	0
Resources Round-up	0
Conference Diary	0
A Comparison of European Union and Turkish Reports on the Statistics of Experimental Animal Use in Toxicity Testing	0
Conference Diary	0
Spotlight on Three Rs Progress	0
Development of Sensitive In Vitro Protocols for the Biocompatibility Testing of Medical Devices and Pharmaceuticals Intended for Contact with the Eyes: Acute Irritation and Phototoxicity Assess	0
Conference Diary	0
Editorial	0
Conference Diary	0
Resources Round-up	0
2023 Michael Balls Award	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Editorial	0
Conference Diary	0
Conference Diary	0
Editorial	0
Editorial	0

Thanks to Reviewers	0
Resources Round-up	0
Editorial	0
Editorial	0
Resources Round-up	0
Resources Round-up	0
Conference Diary	0
An Evaluation of the Replacement of Animal-derived Biomaterials in Human Primary Cell Culture	0
Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)	0
Spotlight on Three Rs Progress	0
Journeying Through Journals: The Publishing Process and How to Maximise Research Impact	0
Resources Round-up	0
Spotlight on Three Rs Progress	0
Resources Round-up	0
Resources Round-up	0
Editorial	0
Spotlight on Three Rs Progress	0
Celebrating Professor Horst Spielmann’s 80th Birthday	0
Conference Diary	0
Resources Round-up	0
Editorial	0
Editorial	0
ATLA Best Poster Award	0
Recent ATLA Awards	0
Spotlight on Three Rs Progress	0
2021 Michael Balls Award	0
Editorial	0
JRC Summer School 2021	0
Spotlight on Three Rs Progress	0
Editorial	0
Progress and Remaining Opportunities to Increase the Use of Animal-free Antibodies in the USA	0
Spotlight on Three Rs Progress	0
Corrigendum to Case Studies Exemplifying the Transition to Animal Component-Free Cell Culture	0
Conference Diary	0
Conference Diary	0
Editorial	0
Conference Diary	0
Spotlight on Three Rs Progress	0
Spotlight on Three Rs Progress	0
Spotlight on Three Rs Progress	0
Spotlight on Three Rs Progress	0
Chemicals 2.0 and Why We Need to Bypass the Gold Standard in Regulatory Toxicology	0
Conference Diary	0
Editorial	0
Resources Round-up	0
Resources Round-up	0
Conference Diary	0
Spotlight on Three Rs Progress	0
Spotlight on Three Rs Progress	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Conference Diary	0
Message from FRAME	0
Resources Round-up	0