Atla-Alternatives to Laboratory Animals

Article	Citations
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model	61
Spotlight on Three Rs Progress	36
Spotlight on Three Rs Progress	33
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC-MS/MS Analysis	30
The Use of Human Tissues for Research: What Investigators Need to Know	27
Conference Diary	26
Resources Round-up	23
Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis	21
The Development of an Animal Product-free, Precision-cut Lung Slice Cryopreservation and Post-thaw Culture Method	20
Progress and Remaining Opportunities to Increase the Use of Animal-free Antibodies in the USA	15
The Rise of Three Rs Centres and Platforms in Europe*	13
A History of the Development of Alternatives to Animals in Research and Testing	11
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022	10
Conference Diary	10
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders	10
Editorial	9
Development of Sensitive In Vitro Protocols for the Biocompatibility Testing of Medical Devices and Pharmaceuticals Intended for Contact with the Eyes: Acute Irritation and Phototoxicity Assess	9
Spotlight on Three Rs Progress	8
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with La	8
Resources Round-up	8
Reviewing Current Guidance for the ‘R’ of Replacement and Rethinking it with the ‘Replacement Checklist’	7
Editorial	7
The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	7
Editorial	7
2021 Michael Balls Award	7

Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs	6
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	6
A Cytotoxicity Assay as an Alternative to the Murine Model for the Potency Testing of Bothrops jararaca Venom and Antivenom: An Intralaboratory Pre-validation Study	6
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	6
Editorial	5
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes	5
Thanks to Reviewers	5
Editorial	5
Corrigendum to Case Studies Exemplifying the Transition to Animal Component-Free Cell Culture	4
Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells	4
Editorial	4
JRC Summer School 2021	4
Resources Round-up	4
Editorial	4
Editorial	4
A New ATLA Associate Editor	3
Accelerating Animal Replacement: How Universities Can Lead — Results of a One-Day Expert Workshop in Zurich, Switzerland	3
Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	3
Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)	3
The Development and Evaluation of Brain and Heart Cell Lines from a Marine Fish for Use in Xenobiotic-Induced Cytotoxicity Testing	3
Lessons for the Future of NAMs from History, Philosophy and Social Studies of Science	3
Conference Diary	3
Editorial	3
Spotlight on Three Rs Progress	3
The Current Status and Work of Three Rs Centres and Platforms in Europe*	3
Spotlight on Three Rs Progress	3
Editorial	3
The Evolution of Regulatory Toxicology: Where is the Gardener?	2
The Use of 3-D Models of Echocardiographic Imaging Planes for Teaching Echocardiography Techniques for Use in Dogs and Cats	2
Spotlight on Three Rs Progress	2
The Use of Artificial Intelligence for the Fast and Effective Identification of Three Rs-based Literature	2
Journeying Through Journals: The Publishing Process and How to Maximise Research Impact	2
Resources Round-up	2
Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids	2
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	2
Resources Round-up	2
ATLA Best Poster Award	2
Conference Diary	2
An Evaluation of the Replacement of Animal-derived Biomaterials in Human Primary Cell Culture	2
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021	2
Use of the Allium cepa Model to Assess the Cytogenotoxicity of Luffariella herdmani Marine Sponge Extract	2
Editorial	2
Transparency in Non-Technical Project Summaries to Promote the Three Rs in Respiratory Disease Research	2
Spotlight on Three Rs Progress	1
Comparison of Long-term Human Precision-cut Lung Slice Culture Methodology and Response to Challenge: An Argument for Standardisation	1
Poster Prizes 2021	1
Biobank Personnel — The Key to its Success	1
The Use of Simulators for Teaching Practical Clinical Skills to Veterinary Students — A Review	1
Corrigendum to Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology — A Potential Driver for Reducing/Replacing Laborato	1
Spotlight on Three Rs Progress	1

JRC Summer School on Non-animal Approaches in Science, May 2021	1
The VEGAHUB Platform: The Philosophy and the Tools	1
Academic Training to Promote the Implementation of Alternative Methods and the Three Rs in the Field of Toxicology	1
Editorial	1
Resources Round-up	1
Conference Diary	1
Alternatives to Laboratory Animals: Trends in Replacement and the Three Rs	1
Resources Round-up	1
The Effects of Urolithin B and Auraptene on Quinolinic Acid-induced Toxicity in the SH-SY5Y Neuroblastoma Cell Line	1
Spotlight on Three Rs Progress	1
An Accessible Nephrectomy and Cystotomy Simulator for Use in Teaching Small Animal Surgery	1
Editorial	1
Conference Diary	1
Resources Round-up	1
Resources Round-up	1
Conference Diary	1
A Comparison of Mesenchymal Stem Cell-derived Hepatocyte-like Cells and HepG2 Cells for Use in Drug-Induced Liver Injury Studies	1
Assessment of a Low-cost Canine Uterine Simulator as a Tool for Teaching the Ovariohysterectomy Technique to Veterinary Students	1
Barriers to the Use of Recombinant Bacterial Endotoxins Test Methods in Parenteral Drug, Vaccine and Device Safety Testing	1
Editorial	1
Message from FRAME	0
An Approach to Setting Vertebrate Animal-use Benchmarks for Agrochemical and GM Crop Testing to Facilitate Future Animal Reduction Efforts	0
Ex Vivo Human Skin: An Alternative Test System for Skin Irritation and Corrosion Assays	0
Editorial	0
The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods	0
Thanks to Reviewers	0
A History of Regulatory Animal Testing: What Can We Learn?	0
Resources Round-up	0
A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study	0
A Comparison of European Union and Turkish Reports on the Statistics of Experimental Animal Use in Toxicity Testing	0
Zebrafish Beyond the Bench: The ‘Plataforma Zebrafish Open Doors’ Programme	0
A History of the Development of Alternatives to Animals in Research and Testing	0
Resources Round-up	0
Editorial	0
Permutation Tests Are a Useful Alternative Approach for Statistical Hypothesis Testing in Small Sample Sizes	0
2023 Michael Balls Award	0
Spotlight on Three Rs Progress	0
Resources Round-up	0
A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage	0
The Use of MPS in Three Rs and Regulatory Applications: Perspectives From Developers on Stakeholder Responsibilities	0
Upholding the EU's Commitment to ‘Animal Testing as a Last Resort' Under REACH Requires a Paradigm Shift in How We Assess Chemical Safety to Close the Gap Between Regulatory Testing and Modern Safety	0
EURL ECVAM Activities	0
Conference Diary	0
An Evaluation of Different Types of Peptone as Partial Substitutes for Animal-derived Serum in Vero Cell Culture	0
It’s Time to Include Harm to Humans in Harm–Benefit Analysis — But How to Do It, That is the Question	0
It’s Time to Review the Three Rs, to Make them More Fit for Purpose in the 21st Century	0
Expression of Concern: “Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway”	0
Editorial	0
Editorial	0
Chitosan–Calcium Aluminate as a Cell-homing Scaffold: Its Bioactivity Testing in a Microphysiological Dental Pulp Platform	0
Conference Diary	0
Curated Data In — Trustworthy In Silico Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing	0
Recent ATLA Awards	0
20 Years of Providing Custom Non-Animal-Derived Antibodies — A Review	0
Editorial	0
Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters	0
Resources Round-up	0
Development of an In Vitro Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells	0
Resources Round-up	0
The Accomplishments of KoCVAM in the Development and Implementation of Alternative Methods in Korea	0
Book Review: Zebrafish Model for Biomedical Research	0
Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health	0
Determination of the Microinjected Cytosolic Concentration by Using Mathematical Models of Fluid Dynamics	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022	0
Resources Round-up	0
Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance	0
Cardiac Transcription Regulators Differentiate Human Umbilical Cord Mesenchymal Stem Cells into Cardiac Cells	0
Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology — A Potential Driver for Reducing/Replacing Laboratory Animals in t	0
Conference Diary	0
Resources Round-up	0
Conference Diary	0
Celebrating Professor Horst Spielmann’s 80th Birthday	0
Towards More Human and Humane Testing: The Role of the Device Supplier Industry	0
Conference Diary	0
Resources Round-up	0
Resources Round-up	0
Resources Round-up	0
2022 Michael Balls Award	0

Spotlight on Three Rs Progress	0
Adapting to Changes in Publishing When Searching for Alternatives and Reporting on Animal Research: A Librarian’s Perspective	0
Chemicals 2.0 and Why We Need to Bypass the Gold Standard in Regulatory Toxicology	0
Conference Diary	0
Thanks to Reviewers	0
The Prevalence of Reported Gavage Incidents in Repeated Dose Toxicity Studies Involving Rats Conducted Between 2004–2023	0
Conference Diary	0
The Capability Maturity Model as a Measure of Culture of Care in Laboratory Animal Science	0
Spotlight on Three Rs Progress	0
The Perceptions of Students and Lecturers on the Use of Animals in Biomedical Science Undergraduate Education in Brazil	0
Conference Diary	0
In Silico Phototoxicity Prediction of Drugs and Chemicals by using Derek Nexus and QSAR Toolbox	0
In Vitro Dengue Virus Inhibition by Aqueous Extracts of Aegle marmelos, Munronia pinnata and Psidium guajava	0
The Use of In Silico Methods to Identify and Assess Antigenic Regions Suitable for the Development of Peptide-based Pan-viral Vaccines	0
Biomedical Research Must Change — But a Shift Toward Human-specific Research Methods Is Only Part of What Is Needed	0
Spotlight on Three Rs Progress	0
Resources Round-up	0
Key Challenges for In Vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for the In Vitro Mouse Lymphoma Assay	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Evaluation of a Low-cost Renal Simulator for the Diagnostic Ultrasound Training of Veterinary Medicine Students	0
Conference Diary	0
Conference Diary	0
Evaluating the Protective Effects of Thymoquinone on Methamphetamine-induced Toxicity in an In Vitro Model Based on Differentiated PC12 Cells	0
Educators’ Views on the Use of Dissection and Dissection Alternatives in American Biology Classrooms	0
Implementing the EURL ECVAM Recommendation on Non-Animal-Derived Antibodies in One EU Member State — Denmark	0
Conference Diary	0
Spotlight on Three Rs Progress	0
Poor Translatability of Biomedical Research Using Animals — A Narrative Review	0
Spotlight on Three Rs Progress	0
Optimisation of Conditions for the Formation of Spheroids of Head and Neck Squamous Cell Carcinoma Cell Lines for Use as Animal Alternatives	0
The In Vitro Evaluation of Preosteoblast Migration From 3-D-printed Scaffolds to Decontaminated Smooth and Minimally Rough Titanium Surfaces: A Pilot Study	0
How to Foster ‘New Approach Methodology’ Toxicologists	0
Spotlight on Three Rs Progress	0
Biomedical Research on Substances of Abuse: The Italian Case Study	0
Editorial	0
Editorial	0
Spotlight on Three Rs Progress	0
Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings	0
Acute Toxicity Assays with the Artemia salina Model: Assessment of Variables	0
Editorial	0
Editorial	0
Conference Diary	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Conference Diary	0
Is UK Animal Research Governance Facing a ‘New Normal’? Considering the Risks and Benefits of ‘Going Online’	0
Cigarette Smoke Constituents and Nicotine Differentially Affect Cytokine Production by Human Macrophages Stimulated by TLR Ligands In Vitro: Considerations for a Standardised Protocol	0
Spotlight on Three Rs Progress	0
Resources Round-up	0
Conference Diary	0
The Use of an In Chemico Digestibility Assay to Reduce the In Vivo Fish Bioaccumulation Testing of Nanomaterials	0
Dr Robert Combes (1946–2021)	0
Spotlight on Three Rs Progress	0
Coculture of ARPE-19 Cells and Porcine Neural Retina as an Ex Vivo Retinal Model	0
Calling all students and early-career researchers — Join us for the second Summer School on Innovative Approaches in Science!	0
Spotlight on Three Rs Progress	0
A Low-fidelity Simulator for the Development of Vascular Ligation Skills	0
Resources Round-up	0
In Silico Prediction of Eye Irritation Using Hansen Solubility Parameters and Predicted pKa Values	0
Editorial	0
Rethinking the Three Rs: Growing Momentum Toward a New Gold Standard in Australian Research	0
Development of an Accessible Gene Expression Bioinformatics Pipeline to Study Driver Mutations of Colorectal Cancer	0
2020 Michael Balls Award	0
A Short History of the Consideration of Sex Differences in Biomedical Research — Lessons for the In Vitro Community from Animal Models and Human Clinical Trials	0
Dr Richard Clothier: FRAME Trustee, Founding Director of the FRAME Laboratory and ATLA Editorial Board Member	0
A Novel Ex Vivo Blinking Method for Comparing the Corneal Residence Time of New Shampoo Formulations	0
Editorial	0
Resources Round-up	0
Thanks to Reviewers	0
Spotlight on Three Rs Progress	0
Resources Round-up	0
Spotlight on Three Rs Progress	0