Atla-Alternatives to Laboratory Animals

Article	Citations
A Review of In Silico Tools as Alternatives to Animal Testing: Principles, Resources and Applications	95
Upholding the EU's Commitment to ‘Animal Testing as a Last Resort' Under REACH Requires a Paradigm Shift in How We Assess Chemical Safety to Close the Gap Between Regulatory Testing and Modern Safety	22
Some Reasons Why Preclinical Studies of Psychiatric Disorders Fail to Translate: What Can Be Rescued from the Misunderstanding and Misuse of Animal ‘Models’?	19
A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage	19
Curated Data In — Trustworthy In Silico Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing	18
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with La	16
Evaluation of the Influence of Astrocytes on In Vitro Blood–Brain Barrier Models	13
The Use of Simulators for Teaching Practical Clinical Skills to Veterinary Students — A Review	13
Poor Translatability of Biomedical Research Using Animals — A Narrative Review	11
Farm Animal-derived Models of the Intestinal Epithelium: Recent Advances and Future Applications of Intestinal Organoids	11
A History of Regulatory Animal Testing: What Can We Learn?	10
The Use of In Silico Tools for the Toxicity Prediction of Potential Inhibitors of SARS-CoV-2	9
The Rise of Three Rs Centres and Platforms in Europe*	9
The VEGAHUB Platform: The Philosophy and the Tools	9
Modulating the Barrier Function of Human Alveolar Epithelial (hAELVi) Cell Monolayers as a Model of Inflammation	8
Alternatives to Laboratory Animals: Trends in Replacement and the Three Rs	8
Prediction of Human Lethal Doses and Concentrations of MEIC Chemicals from Rodent LD50 Values: An Attempt to Make Some Reparation	7
The Evolution of Regulatory Toxicology: Where is the Gardener?	7
Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings	6
An Overview of Current Alternative Models for Use in the Context of Prostate Cancer Research	6
Development of an Accessible Gene Expression Bioinformatics Pipeline to Study Driver Mutations of Colorectal Cancer	6
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	5
The Use of Artificial Intelligence for the Fast and Effective Identification of Three Rs-based Literature	5
Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	5
Ex Vivo Human Skin: An Alternative Test System for Skin Irritation and Corrosion Assays	5

Comparison of Long-term Human Precision-cut Lung Slice Culture Methodology and Response to Challenge: An Argument for Standardisation	5
The First Rehoming of Laboratory Beagles in Finland: The Complete Process from Socialisation Training to Follow-up	4
The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	4
Coculture of ARPE-19 Cells and Porcine Neural Retina as an Ex Vivo Retinal Model	4
Biobank Personnel — The Key to its Success	4
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021	4
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022	4
It’s Time to Include Harm to Humans in Harm–Benefit Analysis — But How to Do It, That is the Question	4
The Current Status and Work of Three Rs Centres and Platforms in Europe*	3
A Comparison of Mesenchymal Stem Cell-derived Hepatocyte-like Cells and HepG2 Cells for Use in Drug-Induced Liver Injury Studies	3
The Effects of Urolithin B and Auraptene on Quinolinic Acid-induced Toxicity in the SH-SY5Y Neuroblastoma Cell Line	3
Biomedical Research on Substances of Abuse: The Italian Case Study	3
Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters	3
The Implementation of the Three Rs in Regulatory Toxicity and Biosafety Assessment: The Indian Perspective	3
The Use of Human Tissues for Research: What Investigators Need to Know	3
Devising a Tier-based Skin Sensitisation Screening Strategy for Personal Care and Cosmetic Products	3
Biomedical Research Must Change — But a Shift Toward Human-specific Research Methods Is Only Part of What Is Needed	3
Culture of Care Enhancement in Egypt: The Impact of Laboratory Animal Science Training on Participants’ Attitudes	3
Cardiac Transcription Regulators Differentiate Human Umbilical Cord Mesenchymal Stem Cells into Cardiac Cells	2
Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance	2
The In Vitro Evaluation of Preosteoblast Migration From 3-D-printed Scaffolds to Decontaminated Smooth and Minimally Rough Titanium Surfaces: A Pilot Study	2
Culture Conditions Affect Chemical-Induced Developmental Toxicity In Vitro: The Case of Folic Acid, Methionine and Methotrexate in the Neural Embryonic Stem Cell Test	2
Towards More Human and Humane Testing: The Role of the Device Supplier Industry	2
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model	2
Qualitative and Quantitative Analysis of Certain Aspects of the Cytotoxic and Genotoxic Hazard of Hospital Wastewaters by Using a Range of In Vitro Assays	2
Development of a Synthetic Training Model for Canine Thoracocentesis	2
The Use of 3-D Models of Echocardiographic Imaging Planes for Teaching Echocardiography Techniques for Use in Dogs and Cats	2
A Short History of the Consideration of Sex Differences in Biomedical Research — Lessons for the In Vitro Community from Animal Models and Human Clinical Trials	2
An Evaluation of Different Types of Peptone as Partial Substitutes for Animal-derived Serum in Vero Cell Culture	2
Optimisation of Conditions for the Formation of Spheroids of Head and Neck Squamous Cell Carcinoma Cell Lines for Use as Animal Alternatives	2
Development of an In Vitro Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells	2
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	2
Adapting to Changes in Publishing When Searching for Alternatives and Reporting on Animal Research: A Librarian’s Perspective	2
A Low-fidelity Simulator for the Development of Vascular Ligation Skills	2
A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study	1
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC-MS/MS Analysis	1
The Use of In Silico Methods to Identify and Assess Antigenic Regions Suitable for the Development of Peptide-based Pan-viral Vaccines	1
The Capability Maturity Model as a Measure of Culture of Care in Laboratory Animal Science	1
Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs	1
Comment from the New Editor-in-Chief: A Journey to Replacement and the Inevitable Question	1
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	1
Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids	1
The Perceptions of Students and Lecturers on the Use of Animals in Biomedical Science Undergraduate Education in Brazil	1
Barriers to the Use of Recombinant Bacterial Endotoxins Test Methods in Parenteral Drug, Vaccine and Device Safety Testing	1
An Overview of the FRAME Summer Studentship 2020 Award Winners	1
In Silico Prediction of Eye Irritation Using Hansen Solubility Parameters and Predicted pKa Values	1
Academic Training to Promote the Implementation of Alternative Methods and the Three Rs in the Field of Toxicology	1
The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods	1
A Human Erythrocyte-based Haemolysis Assay for the Evaluation of Human Complement Activity	1
Transparency in Non-Technical Project Summaries to Promote the Three Rs in Respiratory Disease Research	1

Educators’ Views on the Use of Dissection and Dissection Alternatives in American Biology Classrooms	1
Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health	1
The History of Anti-vivisection Legislation in Turkey and the Role of a New Association	1
The Development and Evaluation of Brain and Heart Cell Lines from a Marine Fish for Use in Xenobiotic-Induced Cytotoxicity Testing	1
Is UK Animal Research Governance Facing a ‘New Normal’? Considering the Risks and Benefits of ‘Going Online’	1
In Vitro Dengue Virus Inhibition by Aqueous Extracts of Aegle marmelos, Munronia pinnata and Psidium guajava	1
The Quality of Reporting Raises Questions on the Experimental Validity of Animal Studies Conducted in India and Sri Lanka: Preliminary Analysis of a Systematic Survey	1
Determination of the Microinjected Cytosolic Concentration by Using Mathematical Models of Fluid Dynamics	1
Zebrafish Beyond the Bench: The ‘Plataforma Zebrafish Open Doors’ Programme	1
How to Foster ‘New Approach Methodology’ Toxicologists	1
Use of the Allium cepa Model to Assess the Cytogenotoxicity of Luffariella herdmani Marine Sponge Extract	1
EURL ECVAM Activities	1
Evaluation of a Low-cost Renal Simulator for the Diagnostic Ultrasound Training of Veterinary Medicine Students	1
Editorial	1
Conference Diary	0
Spotlight on Three Rs Progress	0
Resources Round-up	0
Young Researcher 2018 Lush Prize (Rest of the World)	0
News and Views	0
CAAT News & Views	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Spotlight on Three Rs Progress	0
Resources Round-up	0
Young Researcher 2018 Lush Prize (Asia)	0
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022	0
Conference Diary	0
Conference Diary	0
ATLA Best Poster Award	0
Resources Round-up	0
Spotlight on Three Rs Progress	0
Corrigendum to Case Studies Exemplifying the Transition to Animal Component-Free Cell Culture	0
Editorial	0
Conference Diary	0
Spotlight on Three Rs Progress	0
Resources Round-up	0
The 2018 Lush Prize Conference and Awards Ceremony	0
Lush Prize Conference 2018: The Times They are A-Changin	0
Resources Round-up	0
Spotlight on Three Rs Progress	0
Chitosan–Calcium Aluminate as a Cell-homing Scaffold: Its Bioactivity Testing in a Microphysiological Dental Pulp Platform	0
Editorial	0
Resources Round-up	0
Spotlight on Three Rs Progress	0
News & Views	0
Celebrating Professor Horst Spielmann’s 80th Birthday	0
The Value of Models	0
Resources Round-up	0
Editorial	0
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes	0
Editorial	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Editorial	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Editorial	0
Conference Diary	0
2021 Michael Balls Award	0
Recent ATLA Awards	0
JRC Summer School 2021	0
2020 Michael Balls Award	0
Conference Diary	0
Spotlight on Three Rs Progress	0
Thanks to Reviewers	0
Editorial	0
Resources Round-up	0
Editorial	0
Young Researcher 2018 Lush Prize (Americas)	0
Conference Diary	0
Editorial	0
Spotlight on Three Rs Progress	0
Thanks to Reviewers	0
Conference Diary	0
JRC Summer School on Non-animal Approaches in Science, May 2021	0
Resources Round-up	0
Editorial	0
Editorial	0
Editorial	0
Resources Round-up	0

2018 Lush Science Prize Winner: Dr Dan Huh, BIOLines Research Group, University of Pennsylvania, USA	0
The Andrew Tyler Award	0
Spotlight on Three Rs Progress	0
Dr Robert Combes (1946–2021)	0
2018 Lush Public Awareness Prize Winner: White Coat Waste Project (WCW), USA	0
Spotlight on Three Rs Progress	0
Editorial	0
Announcing the New ATLA Associate Editors	0
Spotlight on Three Rs Progress	0
The 2018 Lush Prize Awards	0
Conference Diary	0
Editorial	0
News and Views	0
Editorial	0
Resources Round-up	0
A New ATLA Associate Editor	0
Editorial	0
Resources Round-up	0
Editorial	0
2018 Lush Training Prize Winner: Laboratory of Education and Research in Pharmacology and Cellular Toxicology, LPCT Team, Brazil	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Resources Round-up	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Key Challenges for In Vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for the In Vitro Mouse Lymphoma Assay	0
Editorial	0
Conference Diary	0
Editorial	0
CAAT News and Views	0
Spotlight on Three Rs Progress	0
Conference Diary	0
2018 Lush Prize Judges	0
Editorial	0
Thanks to Reviewers	0
Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells	0
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders	0
Resources Round-up	0
Corrigendum to The Relevance of In Silico, In Vitro and Non-human Primate Based Approaches to Clinical Research on Major Depressive Disorder	0
Spotlight on Three Rs Progress	0
2018 Lush Science Prize	0
2022 Michael Balls Award	0
Conference Diary	0
Calling all students and early-career researchers — Join us for the second Summer School on Innovative Approaches in Science!	0
Conference Diary	0
Conference Diary	0
Resources Round-up	0
Resources Round-up	0
Editorial	0
Conference Diary	0
Poster Prizes 2021	0
Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis	0
News and Views	0
Resources Round-up	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Book Review: Zebrafish Model for Biomedical Research	0
Resources Round-up	0
2018 Lush Lobbying Prize Winner: Brazilian Network for Humane Education (RedEH), Brazil	0
Conference Diary	0