Journal of Applied Toxicology

Article	Citations
The toxicity of ambient fine particulate matter (PM2.5) to vascular endothelial cells	48
Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO‐1/NQO1 pathway	42
A review of transgenerational and multigenerational toxicology in the in vivo model animal Caenorhabditis elegans	39
Research progress on toxicity, function, and mechanism of metal oxide nanoparticles on vascular endothelial cells	37
α‐Asarone, β‐asarone, and γ‐asarone: Current status of toxicological evaluation	35
Environmental exposure of the general population to cadmium as a risk factor of the damage to the nervous system: A critical review of current data	31
Toxic compounds produced by cyanobacteria belonging to several species of the order Nostocales: A review	31
The impact of environmental and occupational exposures of manganese on pulmonary, hepatic, and renal functions	30
Behavioural effects of early‐life exposure to parabens in zebrafish larvae	26
Aluminium in cosmetics and personal care products	26
Toxic implications of silver nanoparticles on the central nervous system: A systematic literature review	24
Organoids: A new approach in toxicity testing of nanotherapeutics	24
In silico prediction of mitochondrial toxicity of chemicals using machine learning methods	24
Toxicity of orally administered food‐grade titanium dioxide nanoparticles	24
PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome‐mediated hepatocyte pyroptosis	24
Comparative evaluation on the toxic effect of silver (Ag) and zinc oxide (ZnO) nanoparticles on different trophic levels in aquatic ecosystems: A review	23
Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells	22
Potential roles of Kruppel‐like factors in mediating adverse vascular effects of nanomaterials: A review	22
Mechanisms and biological impacts of graphene and multi‐walled carbon nanotubes on Drosophila melanogaster: Oxidative stress, genotoxic damage, phenotypic variations, locomotor behav	22
Toxicity of quantum dots on target organs and immune system	21
Emerging mycotoxins and reproductive effects in animals: A short review	18
Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model	18
Therapeutic nanostructures and nanotoxicity	17
Toxicity of transition metal nanoparticles: A review of different experimental models in the gastrointestinal tract	17
Drosophila melanogaster as a dynamic in vivo model organism reveals the hidden effects of interactions between microplastic/nanoplastic and heavy metals	16

Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish	16
A comparative study of toxicity of graphdiyne and graphene oxide to human umbilical vein endothelial cells	16
Near‐infrared emission Cu, N‐doped carbon dots for human umbilical vein endothelial cell labeling and their biocompatibility in vitro	16
Progress in research on effect of PM2.5 on occurrence and development of atherosclerosis	15
Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives	15
Recent advances in polyphenols improving vascular endothelial dysfunction induced by endogenous toxicity	15
Progress on the toxicity of quantum dots to model organism‐zebrafish	15
Efficacy of water skin decontamination in vivo in humans: A systematic review	15
Cadmium exposure induces endothelial dysfunction via disturbing lipid metabolism in human microvascular endothelial cells	15
Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells	15
Anthraquinones inhibit cytochromes P450 enzyme activity in silico and in vitro	15
Ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane: Toxicological effects on marine biota and human concerns	14
Summary of 17 chemicals evaluated by OECD TG229 using Japanese Medaka,Oryzias latipesin EXTEND 2016	14
Impact of airborne total suspended particles (TSP) and fine particulate matter (PM2.5)‐induced developmental toxicity in zebrafish (Danio rerio) embryos	14
Asthma‐inducing potential of 28 substances in spray cleaning products—Assessed by quantitative structure activity relationship (QSAR) testing and literature review	14
Toxicity evaluation of mesoporous silica particles Santa Barbara No. 15 amorphous in human umbilical vein endothelial cells: influence of particle morphology	14
Research progress on the carcinogenicity of metal nanomaterials	13
Acute and subacute toxicity evaluation of Houttuynia cordata ethanol extract and plasma metabolic profiling analysis in both male and female rats	13
Summary of reference chemicals evaluated by the fish short‐term reproduction assay, OECD TG229, using Japanese Medaka,Oryzias latipes	13
Accumulation of molybdenum in major organs following repeated oral administration of bis‐choline tetrathiomolybdate in the Sprague Dawley rat	13
A pioneer study on human 3‐nitropropionic acid intoxication: Contributions from metabolomics	13
Changes of embryonic development, locomotor activity, and metabolomics in zebrafish co‐exposed to chlorpyrifos and deltamethrin	13
Heavy metals exposure is associated with early liver dysfunction among rural residents aged 40–75 years in southwest China	12
Long‐term exposure to triclosan increases migration and invasion of human breast epithelial cells in vitro	12
Oxidative stress‐mediated apoptosis is involved in bisphenol S‐induced reproductive toxicity in male C57BL/6 mice	12
Curcumin attenuates isoniazid‐induced hepatotoxicity by upregulating the SIRT1/PGC‐1α/NRF1 pathway	12
Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse mod	12
Neurobehavior and neuron damage following prolonged exposure of silver nanoparticles with/without polyvinylpyrrolidone coating in Caenorhabditis elegans	12
Internalization and cytotoxicity of polystyrene microplastics in human umbilical vein endothelial cells	12
In silico prediction of potential drug‐induced nephrotoxicity with machine learning methods	12
Cadmium inhibits neural stem/progenitor cells proliferation via MitoROS‐dependent AKT/GSK‐3β/β‐catenin signaling pathway	12
Design cytotoxicity: The effect of silver nanoparticles stabilized by selected antioxidants on melanoma cells	11
The human health risks assessment of mercury in soils and plantains from farms in selected artisanal and small‐scale gold mining communities around Obuasi, Ghana	11
Antioxidant‐modulated cytotoxicity of silver nanoparticles	11
The reproductive and transgenerational toxicity of microplastics and nanoplastics: A threat to mammalian fertility in both sexes	11
Changes of lipid profiles in human umbilical vein endothelial cells exposed to zirconia nanoparticles with or without the presence of free fatty acids	11
Efficacy of water‐only or soap and water skin decontamination of chemical warfare agents or simulants using in vitro human models: A systematic review	10
Research progress on the cellular toxicity caused by microplastics and nanoplastics	10
Interactive effects of high temperature and pesticide exposure on oxidative status, apoptosis, and renin expression in kidney of goldfish: Molecular and cellular mechanisms of widespread kidney damage	10
Potential issues specific to cytotoxicity tests of cellulose nanofibrils	10
Combating silver nanoparticle‐mediated toxicity in Drosophila melanogaster with curcumin	10
Emodin disrupts the Notch1/Nrf2/GPX4 antioxidant system and promotes renal cell ferroptosis	10
Acridine derivatives as inhibitors/poisons of topoisomerase II	10
Reactive oxygen species‐mediated activation of NLRP3 inflammasome associated with pyroptosis in Het‐1A cells induced by the co‐exposure of nitrosamines	10
Acute and subacute inhalation toxicity assessment of WS‐23 in Sprague–Dawley rats	10
Realgar‐induced nephrotoxicity via ferroptosis in mice	10
Carbofuran cytotoxicity, DNA damage, oxidative stress, and cell death in human umbilical vein endothelial cells: Evidence of vascular toxicity	10
Effect of evernic acid on human breast cancer MCF‐7 and MDA‐MB‐453 cell lines via thioredoxin reductase 1: A molecular approach	10
PM2.5 induces autophagy‐dependent ferroptosis by endoplasmic reticulum stress in SH‐SY5Y cells	10
Lithium toxicity and the kidney with special focus on nephrotic syndrome associated with the acute kidney injury: A case‐based systematic analysis	10

Organophosphorus flame‐retardant tris(1‐chloro‐2‐propyl)phosphate is genotoxic and apoptotic inducer in human umbilical vein endothelial cells	10
Exposure to mono (2‐ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through NLRP3 inflammasome	10
Intratracheal instillation of graphene oxide decreases anti‐virus responses and lipid contents via suppressing Toll‐like receptor 3 in mouse livers	9
Comparative proteomic analysis reveals cytotoxicity induced by graphene oxide exposure in A549 cells	9
The use of in vitro methods in assessing human health risks associated with short‐chain perfluoroalkyl and polyfluoroalkyl substances (PFAS)	9
Toxicological safety evaluation of live Anaerobutyricum soehngenii strain CH106	9
The neuroprotective effects of alpha‐lipoic acid on an experimental model of Alzheimer's disease in PC12 cells	9
Cyanidin‐3‐glucoside protects against high glucose‐induced injury in human nucleus pulposus cells by regulating the Nrf2/HO‐1 signaling	9
Caffeine‐induced neurotoxicity mediated by Nrf2 pathway in PC12 cells and zebrafish larvae	9
The effects of selenium on GPX4‐mediated lipid peroxidation and apoptosis in germ cells	9
Influence of systemic copper toxicity on early development and metamorphosis in Xenopus laevis	9
Toxic effects of nanomaterials for health applications: How automation can support a systematic review of the literature?	9
Evaluation of fentanyl toxicity and metabolism using a zebrafish model	9
Metabolomics approach to study in vivo toxicity of graphene oxide nanosheets	9
NADPH oxidases regulate endothelial inflammatory injury induced by PM2.5 via AKT/eNOS/NO axis	9
Exposure interval to ambient fine particulate matter (PM2.5) collected in Southwest China induced pulmonary damage through the Janus tyrosine protein kinase‐2/signal transducer and activator of transc	9
2D‐Quantitative structure–activity relationship modeling for risk assessment of pharmacotherapy applied during pregnancy	9
The expression profile and bioinformatics analysis of microRNAs in human bronchial epithelial cells treated by beryllium sulfate	9
Maduramicin induces cardiotoxicity via Rac1 signaling‐independent methuosis in H9c2 cells	9
Molecular docking and dynamics simulation to screen interactive potency and stability of fungicide tebuconazole with thyroid and sex hormone‐binding globulin: Implications of endocrine and reproductiv	8
Farnesoid X receptor contributes to oleanolic acid‐induced cholestatic liver injury in mice	8
Toxicological effects of selenium nanoparticles in laboratory animals: A review	8
Structural binding perspectives of common plasticizers and a flame retardant, BDE‐153, against thyroxine‐binding globulin: potential for endocrine disruption	8
Protective effects of lycopene on TiO2 nanoparticle‐induced damage in the liver of mice	8
Cytotoxicity of zinc oxide nanoparticles to innate and adaptive human immune cells	8
Protocatechuic acid ameliorates lipopolysaccharide‐induced kidney damage in mice via downregulation of TLR‐4‐mediated IKBKB/NF‐κB and MAPK/Erk signaling pathways	8
Doxorubicin‐induced delayed‐onset subclinical cardiotoxicity in mice	8
The effect of combined exposure of zinc and nickel on the development of zebrafish	8
Integrating analysis of circular RNA and mRNA expression profiles in doxorubicin induced cardiotoxicity mice	8
Gene expression network related to DNA methylation and miRNA regulation during the process of aflatoxin B1‐induced malignant transformation of L02 cells	8
The toxicity of cell therapy: Mechanism, manifestations, and challenges	8
On‐going consequences of in utero exposure of Pb: An epigenetic perspective	8
L‐carnitine reverses methotrexate‐induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC‐1α/Nrf2/HO‐1 axis	8
Inhibition of hypoxia‐induced HIF‐1α‐mediated autophagy enhances the in vitro antitumor activity of rhein in pancreatic cancer cells	8
Sinensetin attenuates oxygen–glucose deprivation/reperfusion‐induced neurotoxicity by MAPK pathway in human cerebral microvascular endothelial cells	8
Proteomic analysis of zearalenone toxicity on mouse thymic epithelial cells	8
In silico prediction of chemical aquatic toxicity by multiple machine learning and deep learning approaches	8
Evaluation of the effects of herpes simplex glycoprotein B on complement system and cytokines in in vitro models of Alzheimer's disease	8
Protective effect of pterostilbene in a streptozotocin‐induced mouse model of Alzheimer's disease by targeting monoamine oxidase B	8
Effects of plasticizer diisobutyl adipate on the Japanese medaka (Oryzias latipes) endocrine system	8
Downregulation of glucose‐6‐phosphatase expression contributes to fluoxetine‐induced hepatic steatosis	8
Effects of polycaprolactone degradation products on the water flea, Daphnia magna: Carbodiimide additives have acute and chronic toxicity	7
Advances in endocrine toxicity of nanomaterials and mechanism in hormone secretion disorders	7
Induction of autophagy and endoplasmic reticulum autophagy caused by cadmium telluride quantum dots are protective mechanisms of yeast cell	7
α‐Mangostin protects lipopolysaccharide‐stimulated nucleus pulposus cells against NLRP3 inflammasome‐mediated apoptosis via the NF‐κB pathway	7
MicroRNA‐34a‐5p as a promising early circulating preclinical biomarker of doxorubicin‐induced chronic cardiotoxicity	7
Antioxidant dihydrolipolic acid protects against in vitro aluminum‐induced toxicity	7
Cytotoxicity and inflammatory effects in human bronchial epithelial cells induced by polycyclic aromatic hydrocarbons mixture	7
Importance of diet in amphibian metamorphosis‐based studies designed to assess the risk of thyroid active substances	7
In silico prediction of hERG blockers using machine learning and deep learning approaches	7
CdTe quantum dots trigger oxidative stress and endoplasmic reticulum stress‐induced apoptosis and autophagy in rat Schwann cell line RSC96	7
Fraxetin suppresses reactive oxygen species‐dependent autophagy by the PI3K/Akt pathway to inhibit isoflurane‐induced neurotoxicity in hippocampal neuronal cells	7
General toxicity and genotoxicity of altertoxin I: A novel 28‐day multiendpoint assessment in male Sprague–Dawley rats	7
Risk compounds, potential mechanisms and biomarkers of traditional Chinese medicine‐induced reproductive toxicity	7
Liquiritin alleviates alpha‐naphthylisothiocyanate‐induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway	7
Neurodevelopmental toxicity induced by airborne particulate matter	7
Propyl gallate decreases the proliferation of Calu‐6 and A549 lung cancer cells via affecting reactive oxygen species and glutathione levels	7
Chromium exposure altered metabolome and microbiome‐associated with neurotoxicity in zebrafish	7
Physiologically based pharmacokinetic modeling and simulation of cannabinoids in human plasma and tissues	7
An overview of current alternative models in the context of ocular surface toxicity	7
Comparison of P25 and nanobelts on Kruppel‐like factor‐mediated nitric oxide pathways in human umbilical vein endothelial cells	7
Breast cancer, alcohol, and phosphate toxicity	7
Comparing the effects of an exposure to a polycyclic aromatic hydrocarbon mixture versus individual polycyclic aromatic hydrocarbons during monocyte to macrophage differentiation: Mixture exposure res	7
Alendronate reduces the cognitive and neurological disturbances induced by combined doses of d‐galactose and aluminum chloride in mice	6
Exogenous IL‐10 posttreatment along with TLR4 and TNFR1 blockade improves tissue antioxidant status by modulating sepsis‐induced macrophage polarization	6
Influences of repeated exposure to low levels of TiO2 nanoparticles on Kruppel‐like factors in 3D Caco‐2 spheroids and mouse intestines	6
Cellular toxicities of gadolinium‐based contrast agents used in magnetic resonance imaging	6
Effect of ketamine on gene expression in zebrafish embryos	6
Impact of solid lipid nanoparticles on 3T3 fibroblasts viability and lipid profile: The effect of curcumin and resveratrol loading	6
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells	6
Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro	6
Gold nanoparticles regulate the antitumor secretome and have potent cytotoxic effects against prostate cancer cells	6
A development of a graph‐based ensemble machine learning model for skin sensitization hazard and potency assessment	6
Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5‐week study in A/J mice	6
Effects of the mycotoxin metabolite de‐epoxy‐deoxynivalenol (DOM‐1) on embryo development and sperm motility in cattle	6
Biological mechanism of ZnO nanomaterials	6
A novel strategy for the study on molecular mechanism of prostate injury induced by 4,4′‐sulfonyldiphenol based on network toxicology analysis	6
Effects of the uremic toxin indoxyl sulphate on human microvascular endothelial cells	6
Occupational exposure to crystalline silica and peripheral biomarkers: An update	6
Selenium ameliorates aflatoxin B1‐induced uterine injury in female mice and necrosis of human endometrial microvascular endothelial cells	6

Acute exposure to abuse‐like concentrations of toluene induces inflammation in mouse lungs and brain	6
Length difference of multi‐walled carbon nanotubes generates differential cytotoxic responses	6
The role of phenothiazine derivatives in autophagy regulation: A systematic review	6
Fluoxetine‐induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15‐deoxy‐Δ12,14PGJ2	6
The effect and underlying mechanisms of titanium dioxide nanoparticles on glucose homeostasis: A literature review	6
Assessment of ethanol exposure from hand sanitizer use and potential for developmental toxicity in nursing infants	5
The impact of differential lignin S/G ratios on mutagenicity and chicken embryonic toxicity	5
Distributions for time, interspecies and intraspecies extrapolation for deriving occupational exposure limits	5
Nonclinical safety assessment of an mRNA Covid‐19 vaccine candidate following repeated administrations and biodistribution	5
Oxidative stress‐mediated epidermal growth factor receptor activation by cigarette smoke or heated tobacco aerosol in human primary bronchial epithelial cells from multiple donors	5
Comparison of cytotoxicity of Ag/ZnO and Ag@ZnO nanocomplexes to human umbilical vein endothelial cells in vitro	5
Oncolytic virus preclinical toxicology studies	5
Differential effects of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats	5
Relationship between osteoid formation and iron deposition induced by chronic cadmium exposure in ovariectomized rats	5
Multiple pathways are responsible to the inhibitory effect of butorphanol on OGD/R‐induced apoptosis in AC16 cardiomyocytes	5
The mechanism and effects of remdesivir‐induced developmental toxicity in zebrafish: Blood flow dysfunction and behavioral alterations	5
Particle surface functionalization affects mechanism of endocytosis and adverse effects of silver nanoparticles in mammalian kidney cells	5
Cytotoxic and immunological responses of fish leukocytes to nodularin exposure in vitro	5
Use of the benchmark‐dose (BMD) approach to derive occupational exposure limits (OELs) for genotoxic carcinogens: N‐nitrosamines	5
Approaches for setting occupational exposure limits in the pharmaceutical industry	5
Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish	5
SiO2 stimulates macrophage stress to induce the transformation of lung fibroblasts into myofibroblasts and its relationship with the sphingomyelin metabolic pathway	5
Lead‐induced neurodevelopmental lesion and epigenetic landscape: Implication in neurological disorders	5
Influence of water hardness on zinc toxicity in Daphnia magna	5
A scoping review of evaluations of and recommendations for default uncertainty factors in human health risk assessment	5
Snake venom toxins: Potential anticancer therapeutics	5
Mortality of workers employed in refractory ceramic fiber manufacturing: An update	5
Quantitative neurotoxicology: Potential role of artificial intelligence/deep learning approach	5
A hypothesis concerning the role of PPAR family on cardiac energetics in Adriamycin‐induced cardiomyopathy	5
Protective potential of thymoquinone against cadmium, arsenic, and lead toxicity: A short review with emphasis on oxidative pathways	5
The impact of PM2.5 on kidney	5
Developmental effects of siloxane exposure in zebrafish: A comparison study using laboratory‐mixed and environmental water samples	5
Cadmium as an ovarian toxicant: A review	5
The role of AMP‐activated protein kinase α1‐mediated endoplasmic reticulum stress in alleviating the toxic effect of uremic toxin indoxyl sulfate on vascular endothelial cells by Klotho	5
Exposure to boron trioxide nanoparticles and ions cause oxidative stress, DNA damage, and phenotypic alterations in Drosophila melanogaster as an in vivo model	5
The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity	5
Reproductive toxicity of maternal exposure to di(2‐ethylhexyl)phthalate and butyl paraben (alone or in association) on both male and female Wistar offspring	5
Acceptable surface limits (ASLs) of skin sensitizers derived from the local lymph node assay (LLNA): BrdU‐ELISA EC1.6 values and their relationships to known sensitization potency information	5
Evaluation of the genotoxic potential of protoporphyrin IX and the safety of a protoporphyrin IX‐rich algal biomass	5