Journal of Applied Toxicology

Article	Citations
The Role of PI3K/AKT/HIF‐1α Pathway in the Effect of Nano‐TiO2 on Lactate Production in TM4 Cells	68
Induction of autophagy and endoplasmic reticulum autophagy caused by cadmium telluride quantum dots are protective mechanisms of yeast cell	55
Issue Information	55
Esculin alleviates lipopolysaccharide (LPS)–induced pneumonia by regulating the USP7/MAPK14 axis	47
Rsad2 mediates Bisphenol A‐induced actin cytoskeletal disruption in mouse spermatocytes	41
Dose‐Dependent Hepatorenal Damage Induced by Erythrosine: A Study of Biochemical, Oxidative Stress, DNA Damage, and Histopathological Effects in Wistar Rats	39
Exposure to aerosolized staphylococcal enterotoxin B potentiated by lipopolysaccharide modifies lung transcriptomes and results in lung injury in the mouse model	36
Oleanolic acid induces hepatic injury by disrupting hepatocyte tight junction and dysregulation of farnesoid X receptor‐mediated bile acid efflux transporters	35
A scoping review of evaluations of and recommendations for default uncertainty factors in human health risk assessment	32
Intestinal Bacterial Dysbiosis and Liver Fibrosis in Mice Through Gut‐Liver Axis and NLRP3 Inflammatory Pathway Caused by Fine Particulate Matter	29
α‐Mangostin protects lipopolysaccharide‐stimulated nucleus pulposus cells against NLRP3 inflammasome‐mediated apoptosis via the NF‐κB pathway	29
Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum‐induced neurotoxicity in an in vitro Alzheimer's disease model	28
Titanium dioxide nanoparticles induce apoptosis through ROS‐Ca2+‐p38/AKT/mTOR pathway in TM4 cells	27
FOXA1‐TET1 Mediate the DNA Hypomethylation of IL‐4 Is Involved in Dust Fall PM2.5 Induced Lung Inflammation	26
The Role of TLR4 in the Intestinal Barrier and Its Relationship With Nanoparticle‐Induced Intestinal Injury	26
Allergenicity, Genotoxicity and Subchronic Toxicity Assessment of IgG Binding Protein LT Produced From Aspergillus oryzae	25
Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells	25
Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii	24
Impact of Embryonic Exposure of Atrazine on the Physiological and Behavioral Parameters in Drosophila melanogaster	23
Nicotine as a female reproductive toxicant—A review	23
Emodin disrupts the Notch1/Nrf2/GPX4 antioxidant system and promotes renal cell ferroptosis	22
The Proteome of African Spitting and Non‐Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells	21
Issue Information	21
Issue Information	21
Arsenic and Chromium Induced Toxicity on Zebrafish Kidney: Mixture Effects on Oxidative Stress and Involvement of Nrf2‐Keap1‐ARE, DNA Repair, and Intrinsic Apoptotic Pathways	21

Impact of Lacosamide, Silver Nanoparticles, and Their PEG‐Conjugates on Life History Traits and Behavioral Responses in parabss1 Mutant Drosophila	21
Preclinical Toxicological Assessment of 2‐(Benzoxazol‐2‐yl)[(2‐hydroxynaphthyl)diazenyl]phenol Derivatives for Blue Light and UV Radiation Photoprotection Applications	20
Dose and exposure route analyses inform relationships between liver steatosis and 2‐amino‐2‐methyl‐1‐propanol: Implications for hazard characterization	19
Bacillus subtilis ZB423: 90‐Day repeat dose oral (gavage) toxicity study in Wistar rats	18
A 90‐day preclinical toxicological evaluation in rats of a highly purified and concentrated mulberry leaf extract	18
Quercetin ameliorates Helicobacter pylori‐induced gastric epithelial cell injury by regulating specificity protein 1/lipocalin 2 axis in gastritis	18
Black Carbon, Oxidative Potential, and Zebrafish Toxicity: A Toxicological Study of PM2.5 in Tennessee	17
Flame retardant, hexabromocyclododecane, increases production of pro‐inflammatory cytokines, interleukin 1‐beta and interleukin 6, in human immune cells	17
Oral Administration of Cadmium Chloride Induces Oxidative Stress, DNA Damage and Histopathological Changes in Rat Intestine: A Dose‐Dependent Study	17
The Relationship Between Mercury Exposure and Membranous Nephropathy: Case Reports and Meta‐Analysis	17
2D‐Quantitative structure–activity relationship modeling for risk assessment of pharmacotherapy applied during pregnancy	17
Toxicological Impacts of Arecoline and Tobacco in Oral Submucous Fibrosis: Mechanisms and Therapeutic Insights	17
The role of phenothiazine derivatives in autophagy regulation: A systematic review	16
Toxicological Evaluation of the Sweet Protein Brazzein Derived From Komagataella phaffii for Use as a Sweetener in Foods and Beverages	16
Exposure to Polyethylene Terephthalate Microplastic Induces Mouse Liver Fibrosis Through Oxidative Stress and p38 MAPK/p65 NF‐κB Signaling Pathway	16
The role of receptor‐mediated activities of 4‐ and 5‐ring unsubstituted and methylated polycyclic aromatic hydrocarbons (PAHs) in developmental toxicity	16
Antitumor Cytotoxic Activity Retained in Tolerized T Cells Following Daily Dose Escalation of a T‐Cell Engager in Cynomolgus Monkeys to Mitigate Cytokine Release Syndrome	16
Issue Information	15
Oxidative Stress in Kidney of Zebrafish due to Individual and Combined Exposure to Amoxicillin, Arsenic, and Fluoride: Involving Nrf2‐Keap1‐ARE Pathway	15
A Brief Review of the Role of Macrophage Hypoxia in SiO2‐Induced Pulmonary Fibrosis	15
Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies	15
Realgar‐induced nephrotoxicity via ferroptosis in mice	15
Study of Serum Metabolic Biomarkers and Prediction Models of Cantharidin‐Induced Nephrotoxicity in Rats Based on Dynamic Metabolomics	14
Biological effects of molybdenum(IV) sulfide nanoparticles and microparticles in the rat after repeated intratracheal administration	14
Mechanism of subchronic vinyl chloride exposure combined with a high‐fat diet on hepatic steatosis	14
Isoflurane preconditioning attenuates OGD/R‐induced cardiomyocyte cytotoxicity by regulating the miR‐210/BNIP3 axis	14
Inhibition of voltage‐dependent K+ channels in rabbit coronary arterial smooth muscle cells by the atypical antipsychotic agent sertindole	14
Subchronic Inhalation of TiO2 Nanoparticles Leads to Deposition in the Lung and Alterations in Erythrocyte Morphology in Mice	13
Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish	13
	13
Umbelliferone protects against methylglyoxal‐induced HUVECs dysfunction through suppression of apoptosis and oxidative stress	13
Perfluorooctane sulfonate promotes hepatic lipid accumulation and steatosis in high‐fat diet mice through AMP‐activated protein kinase/acetyl‐CoA carboxylase (AMPK/ACC) pathway	13
Toxicokinetic Profiles and Potential Endocrine Disruption Effects at the Reproductive Level Promoted by Siloxanes Used in Consumer Products	13
Hepatotoxicity of titanium dioxide nanoparticles	12
Nuciferine protects hyperandrogen‐injured ovarian granulosa cells by inhibiting ferroptosis via SOX2‐mediated activation of the SLC7A11/GPX4 axis	12
Human Relevance of Pharmaceutical Drug‐Induced Thyroid Tumors in Rats, Labeling Implications, and Carcinogenicity Study Requirements	12
The chorioallantoic membrane: A novel approach to extrapolate data from a well‐established method	12
2,3′,4,4′,5‐Pentachlorobiphenyl attenuated fast‐twitch fibers and fiber size of skeletal muscle via disturbing thyroid hormone signaling and mitochondrial dynamics	12
Issue Information	12
Xylazine‐Adulterated Fentanyl‐Induced Brain Toxicity: Mechanism Elucidation via Network Toxicology and Molecular Docking Approaches	12
Hydrogen sulfide alleviates beryllium sulfate‐induced ferroptosis and ferritinophagy in 16HBE cells	12
The mechanism and effects of remdesivir‐induced developmental toxicity in zebrafish: Blood flow dysfunction and behavioral alterations	12
Circ_0027470 promotes cadmium exposure‐induced prostatic fibrosis via sponging miRNA‐1236‐3p and stimulating SHH signaling pathway	11
Adverse effect of FTY720P on colonic Na+/K+ ATPase is mediated via ERK, p38MAPK, PKC, and PI3K	11
Novel ferrocene‐containing triacyl derivative of resveratrol improves viability parameters in ovary cells	11
The Impact of NO2 on Epithelial Barrier Integrity of a Primary Cell‐Based Air–Liquid Interface Model of the Nasal Respiratory Epithelium	11
Epithelial–Mesenchymal Transition in Human Alveolar Cells Exposed to Indium Chloride	11
Mulberrin extends lifespan in Caenorhabditis elegans through detoxification function	11
Associations of bisphenol F and S, as substitutes for bisphenol A, with cardiovascular disease in American adults	11
	11

A pioneer study on human 3‐nitropropionic acid intoxication: Contributions from metabolomics	11
Investigation of the mechanisms behind ochratoxin A‐induced cytotoxicity in human astrocytes and the protective effects of N‐acetylcysteine	11
Using particle dimensionality‐based modeling to estimate lung carcinogenicity of 3D printer emissions	11
TCDD Induces Hepatocytes Lipid Deposition via Downregulation of MFN2	10
Acute exposure to abuse‐like concentrations of toluene induces inflammation in mouse lungs and brain	10
Environmentally relevant lead alters nuclear integrity in erythrocytes and generates oxidative stress in liver of Anabas testudineus: Involvement of Nrf2‐Keap1 regulation and express	10
Evaluating Solvent Safety in Chromosome Aberration Assays for Genetic Toxicology	10
Cadmium as an ovarian toxicant: A review	10
In vitro evaluation of the inhalation toxicity of the cosmetic ingredient aluminum chlorohydrate	10
The Molecular Mechanism of miRNA‐195‐5p Regulating ERK Involvement in Abnormal Phosphorylation of Tau Protein by Aluminum Maltol in PC12 Cells	10
Transgenerational Reproductive and Developmental Toxicity Induced by N‐Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster	10
Issue Information	10
Lowering the pH leads to the disaggregation of NiO and ZnO nanoparticles and modifies the mutagenic response	10
Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish	10
In silico prediction of ocular toxicity of compounds using explainable machine learning and deep learning approaches	10
A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin	10
A systematic review on multipotent carcinogenic agent, N‐nitrosodiethylamine (NDEA), its major risk assessment, and precautions	10
Transcriptome Analysis Suggests Chronic Toxic Effects of 1‐Ethyl‐3‐(3‐Dimethylaminopropyl)carbodiimide in Daphnia magna via Induction of Endoplasmic Reticulum Stress	9
	9
CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan	9
A proposed in vitro cytotoxicity test battery to detect and predict hepatotoxicity via multiple mechanisms and pathways: a minireview	9
Caenorhabditis elegans CYP33 Family in Eicosanoid Regulation, Xenobiotic Metabolism, Nanotoxicity and Spermatogenesis	9
Cigarette smoke interacts with amiodarone toxicity in Saccharomyces cerevisiae	9
Impact of Oxidative Stress on Reproductive Toxicity Induced by Alpha‐Terpineol in Male Sprague–Dawley Rats	9
Glycyrrhetinic acid ameliorates diosbulbin B‐induced hepatotoxicity in mice by modulating metabolic activation of diosbulbin B	9
Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells	9
Hepatotoxicity of cantharidin is associated with the altered bile acid metabolism	9
Safety Assessment of Butyric Acid‐Rich Triglyceride Oil: A Novel Palatable Formulation of Butyrate for the Pediatric Population	9
Assessing the Sublethal Effects of Dibutyl Adipate on Unio Delicatus: Biochemical and Histopathological Insights	9
Issue Information	9
Toxicological effects of selenium nanoparticles in laboratory animals: A review	9
Issue Information	9
Revealing the Impact of Mono(2‐ethylhexyl) Phthalate (MEHP) on Prostate Cancer Based on Network Toxicology and Molecular Docking Approaches	9
Tumours modulate the systemic vascular response to anti‐angiogenic therapy	9
Toxicity evaluation of main zopiclone impurities based on quantitative structure–activity relationship models and in vitro tests	9
Colchicine disrupts bile acid metabolic homeostasis by affecting the enterohepatic circulation in mice	8
Issue Information	8
Disruption of neurosteroid synthesis and release by tris(2,3‐dibromopropyl)isocyanurate in primary mouse cortical astrocytes in vitro	8
Samarium Oxide Exposure Induces Toxicity and Cardiotoxicity in Zebrafish Embryos Through Apoptosis Pathway	8
Serum biomarkers of isoniazid‐induced liver injury: Aminotransferases are insufficient, and OPN, L‐FABP and HMGB1 can be promising novel biomarkers	8
Histopathological Effects of Anthropogenic Toxic Element Pollution in Freshwater Fishes in Their Natural Environments: A Global Review	8
A development of a graph‐based ensemble machine learning model for skin sensitization hazard and potency assessment	8
Environmental Aromatic Amine Induces Pulmonary Arterial Hypertension Associated With Estrogen Signaling and Serpine1	8
Time‐course analysis of pulmonary inflammation induced by intratracheal instillation of nanosized crystalline silica particles in F344 rats	8
Antioxidant dihydrolipolic acid protects against in vitro aluminum‐induced toxicity	8
Metabolomics approach to study in vivo toxicity of graphene oxide nanosheets	8
Liquiritin alleviates alpha‐naphthylisothiocyanate‐induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway	8
Anti‐Candida activity and in vitro toxicity screening of antifungals complexed with β‐cyclodextrin	8
	8
The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells	8
Assessment of commercial polymers with and without reactive groups using amino acid derivative reactivity assay based on both molar concentration approach and gravimetric approach	8
Structural binding perspectives of common plasticizers and a flame retardant, BDE‐153, against thyroxine‐binding globulin: potential for endocrine disruption	8
In silico prediction of chemical aquatic toxicity by multiple machine learning and deep learning approaches	8
	7
Evaluating the Genotoxicity and Mutagenicity of Food Contaminants: Acrylamide, Penitrem A, and 3‐Acetyldeoxynivalenol in Individual and Combined Exposure In Vitro	7
	7
Toxicology and safety study of L‐tryptophan and its impurities for use in broiler feed	7
mtDNA amplifies beryllium sulfate‐induced inflammatory responses via the cGAS‐STING pathway in 16HBE cells	7
Non‐clinical safety evaluation of Yongdamsagan‐tang water extract: A 13‐week subchronic oral toxicity study in Sprague Dawley rats	7
Leukemia Inhibitory Factor via JAK‐STAT Signaling Drives Beryllium Sulfate–Induced Epithelial–Mesenchymal Transition in 16HBE Cells	7
Evaluation of immunotoxicity of sodium metavanadate following drinking water exposure in female B6C3F1/N mice in a 28‐day study	7
Developmental and reproductive toxicity hazard characterization of 2‐amino‐2‐methyl‐1‐propanol (AMP)	7
Featured Cover	7
A novel alternative method for long‐term evaluation of male reproductive toxicity and its recovery using a pre‐pubertal mouse testis organ culture system	7
Effect of renal tubular damage on non‐cancer mortality in the general Japanese population living in cadmium non‐polluted areas	7
Risk compounds, potential mechanisms and biomarkers of traditional Chinese medicine‐induced reproductive toxicity	7
Exposure to thiourea during the early stages of development impedes the formation of the swim bladder in zebrafish larvae	6
	6
Epigenetic alternations in the SYP and DLG4 genes due to low‐level methylmercury exposure during neuronal differentiation in vitro	6
Screening potential anaphylactoid components in vinpocetine injection using a high expression Mas‐related G‐protein‐coupled receptor X2 cell membrane chromatography	6
Euxanthone inhibits lipopolysaccharide‐induced injury, inflammatory response, and MUC5AC hypersecretion in human airway epithelial cells by the TLR4/MyD88 pathway	6
	6
	6
Issue Information	6
Thyroid Endocrine Disrupting Potential of Fluoxetine in Zebrafish Larvae	6
Evidence for exposure biomarkers in dictamnine‐induced liver injury resulting from metabolic activation in vitro and in mice	6
Physiologically‐based pharmacokinetic model of in vitro porcine ear skin permeation for drug delivery research	6
90‐day oral toxicity study in rats of a protein‐rich powder derived fromXanthobactersp. SoF1	6
	6
Oral exposure to citrinin significantly exacerbates the pathophysiology of a mouse model of imiquimod‐induced psoriasis via direct activation of dendritic cell	6

Disruption of vitamin A homeostasis by the biocide tetrakis(hydroxymethyl) phosphonium sulphate in pregnant rabbits	6
In vitro exposure of porcine spermatozoa to methylparaben, and propylparaben, alone or in combination adversely affects sperm quality	6
Impact of Industrial Pollution on Human Renal Function and Male Reproductive Hormones: An Investigation of Heavy Metals Toxicity and Oxidative Stress	6
Particle surface functionalization affects mechanism of endocytosis and adverse effects of silver nanoparticles in mammalian kidney cells	5
Physiologically based pharmacokinetic modeling and simulation of cannabinoids in human plasma and tissues	5
A novel strategy for the study on molecular mechanism of prostate injury induced by 4,4′‐sulfonyldiphenol based on network toxicology analysis	5
Influence of systemic copper toxicity on early development and metamorphosis in Xenopus laevis	5
Toxic Effects of CdTe Quantum Dots on Locomotor Behavior, Neurodevelopment, and Axon Growth in Zebrafish Larvae	5
Comparison of the sensitivity of histopathological and immunohistochemical analyses and blood hormone levels for early detection of antithyroid effects in rats treated with thyroid peroxidase inhibito	5
Issue Information	5
Protective Effects of Atorvastatin on LPS‐Induced Testicular Damage: Modulation of Spermatogenesis via PPAR‐γ, NF‐κB, and NLRP3 Pathways	5
Crotalus atrox venom‐induced cellular toxicity: Early wound progression involves reactive oxygen species	5
Oxidative Stress Biomarkers in Gasoline Station Workers Chronically Exposed to Heavy Metals in Erbil City	5
Effect of Ulinastatin Combined With High‐Volume Hemofiltration on Inflammatory Response and MODS Incidence in Severe Sepsis	5
	5
Nonclinical safety and immunogenicity assessment of a combined DTacP vaccine in animal models	5
General toxicity and genotoxicity of altertoxin I: A novel 28‐day multiendpoint assessment in male Sprague–Dawley rats	5
Arsenic‐Induced Inflammatory Response via ROS‐Dependent Activation of ERK/NF‐kB Signaling Pathways: Protective Role of Natural Polyphenol Tannic Acid	5
CdTe quantum dots trigger oxidative stress and endoplasmic reticulum stress‐induced apoptosis and autophagy in rat Schwann cell line RSC96	5
In silico analysis of endocrine‐disrupting potential of triclosan, bisphenol A, and their analogs and derivatives	5
Endogenous humoral determinants of vascular endothelial dysfunction as triggers of acute poisoning complications	5
Modification of Oxidative Stress Induced by Exposure to Arsenate in Rat Chondrocytes Treated With Chitosan–Glutathione Nanoparticles	5
The Role of CXCL13 in GC‐1 Cell Cycle Arrest Induced by Titanium Dioxide Nanoparticles Through JAK2/STAT3 Signaling Pathway	5
The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity	5
Characterisation of ChE in Solea solea and exposure of isoflavones in juveniles of commercial flatfish (Solea solea and Solea senegalensis)	5
Fraxetin suppresses reactive oxygen species‐dependent autophagy by the PI3K/Akt pathway to inhibit isoflurane‐induced neurotoxicity in hippocampal neuronal cells	5
Issue Information	5
Oxidative DNA damage contributes to usnic acid‐induced toxicity in human induced pluripotent stem cell‐derived hepatocytes	5
The apoptosis induced by CdTe quantum dots through the mitochondrial pathway in dorsal root ganglion cell line ND7/23	5
Methylglyoxal‐induced neurotoxic effects in primary neuronal‐like cells transdifferentiated from human mesenchymal stem cells: Impact of low concentrations	5