Journal of Applied Toxicology

Article	Citations
Induction of autophagy and endoplasmic reticulum autophagy caused by cadmium telluride quantum dots are protective mechanisms of yeast cell	59
Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum‐induced neurotoxicity in an in vitro Alzheimer's disease model	48
A scoping review of evaluations of and recommendations for default uncertainty factors in human health risk assessment	48
A comparative study of toxicity of graphdiyne and graphene oxide to human umbilical vein endothelial cells	37
The Role of PI3K/AKT/HIF‐1α Pathway in the Effect of Nano‐TiO2 on Lactate Production in TM4 Cells	37
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Nicotine as a female reproductive toxicant—A review	35
Exposure to aerosolized staphylococcal enterotoxin B potentiated by lipopolysaccharide modifies lung transcriptomes and results in lung injury in the mouse model	33
Oleanolic acid induces hepatic injury by disrupting hepatocyte tight junction and dysregulation of farnesoid X receptor‐mediated bile acid efflux transporters	31
Intestinal Bacterial Dysbiosis and Liver Fibrosis in Mice Through Gut‐Liver Axis and NLRP3 Inflammatory Pathway Caused by Fine Particulate Matter	31
Arsenic and Chromium Induced Toxicity on Zebrafish Kidney: Mixture Effects on Oxidative Stress and Involvement of Nrf2‐Keap1‐ARE, DNA Repair, and Intrinsic Apoptotic Pathways	29
Dose‐Dependent Hepatorenal Damage Induced by Erythrosine: A Study of Biochemical, Oxidative Stress, DNA Damage, and Histopathological Effects in Wistar Rats	26
Titanium dioxide nanoparticles induce apoptosis through ROS‐Ca2+‐p38/AKT/mTOR pathway in TM4 cells	26
Esculin alleviates lipopolysaccharide (LPS)–induced pneumonia by regulating the USP7/MAPK14 axis	24
α‐Mangostin protects lipopolysaccharide‐stimulated nucleus pulposus cells against NLRP3 inflammasome‐mediated apoptosis via the NF‐κB pathway	23
Mercury immunotoxicity in the brown watersnake (Nerodia taxispilota): An in vitro study	23
Emodin disrupts the Notch1/Nrf2/GPX4 antioxidant system and promotes renal cell ferroptosis	22
Allergenicity, Genotoxicity and Subchronic Toxicity Assessment of IgG Binding Protein LT Produced From Aspergillus oryzae	22
The neuroprotective effects of alpha‐lipoic acid on an experimental model of Alzheimer's disease in PC12 cells	21
Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii	20
Dose and exposure route analyses inform relationships between liver steatosis and 2‐amino‐2‐methyl‐1‐propanol: Implications for hazard characterization	20
Rsad2 mediates Bisphenol A‐induced actin cytoskeletal disruption in mouse spermatocytes	20
Issue Information	20
Bacillus subtilis ZB423: 90‐Day repeat dose oral (gavage) toxicity study in Wistar rats	19
The role of phenothiazine derivatives in autophagy regulation: A systematic review	19

Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies	19
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Oxidative Stress in Kidney of Zebrafish due to Individual and Combined Exposure to Amoxicillin, Arsenic, and Fluoride: Involving Nrf2‐Keap1‐ARE Pathway	18
Preclinical Toxicological Assessment of 2‐(Benzoxazol‐2‐yl)[(2‐hydroxynaphthyl)diazenyl]phenol Derivatives for Blue Light and UV Radiation Photoprotection Applications	18
A 90‐day preclinical toxicological evaluation in rats of a highly purified and concentrated mulberry leaf extract	17
The Relationship Between Mercury Exposure and Membranous Nephropathy: Case Reports and Meta‐Analysis	17
The role of receptor‐mediated activities of 4‐ and 5‐ring unsubstituted and methylated polycyclic aromatic hydrocarbons (PAHs) in developmental toxicity	17
Flame retardant, hexabromocyclododecane, increases production of pro‐inflammatory cytokines, interleukin 1‐beta and interleukin 6, in human immune cells	17
Realgar‐induced nephrotoxicity via ferroptosis in mice	16
Issue Information	16
2D‐Quantitative structure–activity relationship modeling for risk assessment of pharmacotherapy applied during pregnancy	16
A pioneer study on human 3‐nitropropionic acid intoxication: Contributions from metabolomics	16
Quercetin ameliorates Helicobacter pylori‐induced gastric epithelial cell injury by regulating specificity protein 1/lipocalin 2 axis in gastritis	16
Hepatotoxicity of titanium dioxide nanoparticles	16
Study of Serum Metabolic Biomarkers and Prediction Models of Cantharidin‐Induced Nephrotoxicity in Rats Based on Dynamic Metabolomics	16
Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish	15
Nuciferine protects hyperandrogen‐injured ovarian granulosa cells by inhibiting ferroptosis via SOX2‐mediated activation of the SLC7A11/GPX4 axis	15
Mechanism of subchronic vinyl chloride exposure combined with a high‐fat diet on hepatic steatosis	15
Hydrogen sulfide alleviates beryllium sulfate‐induced ferroptosis and ferritinophagy in 16HBE cells	14
Toxicokinetic Profiles and Potential Endocrine Disruption Effects at the Reproductive Level Promoted by Siloxanes Used in Consumer Products	13
Inhibition of voltage‐dependent K+ channels in rabbit coronary arterial smooth muscle cells by the atypical antipsychotic agent sertindole	13
Biological effects of molybdenum(IV) sulfide nanoparticles and microparticles in the rat after repeated intratracheal administration	13
Exposure to ethylparaben and propylparaben interfere with embryo implantation by compromising endometrial decidualization in early pregnant mice	13
Establishment of an in vitro method of rabbit embryo toxicity with toxicokinetics study	13
Perfluorooctane sulfonate promotes hepatic lipid accumulation and steatosis in high‐fat diet mice through AMP‐activated protein kinase/acetyl‐CoA carboxylase (AMPK/ACC) pathway	13
The impact of differential lignin S/G ratios on mutagenicity and chicken embryonic toxicity	13
The chorioallantoic membrane: A novel approach to extrapolate data from a well‐established method	13
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The mechanism and effects of remdesivir‐induced developmental toxicity in zebrafish: Blood flow dysfunction and behavioral alterations	12
2,3′,4,4′,5‐Pentachlorobiphenyl attenuated fast‐twitch fibers and fiber size of skeletal muscle via disturbing thyroid hormone signaling and mitochondrial dynamics	12
Umbelliferone protects against methylglyoxal‐induced HUVECs dysfunction through suppression of apoptosis and oxidative stress	12
The effects of thirdhand smoke on reproductive health	12
Subchronic Inhalation of TiO2 Nanoparticles Leads to Deposition in the Lung and Alterations in Erythrocyte Morphology in Mice	12
Associations of bisphenol F and S, as substitutes for bisphenol A, with cardiovascular disease in American adults	12
Human Relevance of Pharmaceutical Drug‐Induced Thyroid Tumors in Rats, Labeling Implications, and Carcinogenicity Study Requirements	12
Lowering the pH leads to the disaggregation of NiO and ZnO nanoparticles and modifies the mutagenic response	12
Isoflurane preconditioning attenuates OGD/R‐induced cardiomyocyte cytotoxicity by regulating the miR‐210/BNIP3 axis	12
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Adverse effect of FTY720P on colonic Na+/K+ ATPase is mediated via ERK, p38MAPK, PKC, and PI3K	11
Novel ferrocene‐containing triacyl derivative of resveratrol improves viability parameters in ovary cells	11
Mulberrin extends lifespan in Caenorhabditis elegans through detoxification function	11
Circ_0027470 promotes cadmium exposure‐induced prostatic fibrosis via sponging miRNA‐1236‐3p and stimulating SHH signaling pathway	11
The Impact of NO2 on Epithelial Barrier Integrity of a Primary Cell‐Based Air–Liquid Interface Model of the Nasal Respiratory Epithelium	11
A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin	11
Acute exposure to abuse‐like concentrations of toluene induces inflammation in mouse lungs and brain	11
Environmentally relevant lead alters nuclear integrity in erythrocytes and generates oxidative stress in liver of Anabas testudineus: Involvement of Nrf2‐Keap1 regulation and express	11
A systematic review on multipotent carcinogenic agent, N‐nitrosodiethylamine (NDEA), its major risk assessment, and precautions	10
The Molecular Mechanism of miRNA‐195‐5p Regulating ERK Involvement in Abnormal Phosphorylation of Tau Protein by Aluminum Maltol in PC12 Cells	10
Investigation of the mechanisms behind ochratoxin A‐induced cytotoxicity in human astrocytes and the protective effects of N‐acetylcysteine	10
Transgenerational Reproductive and Developmental Toxicity Induced by N‐Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster	10

In vitro evaluation of the inhalation toxicity of the cosmetic ingredient aluminum chlorohydrate	10
Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish	10
Cadmium as an ovarian toxicant: A review	10
Drug‐induced liver injury: Oltipraz and C2‐ceramide intervene HNF‐1α/GSTA1 expression via JNK signaling pathway	10
Using particle dimensionality‐based modeling to estimate lung carcinogenicity of 3D printer emissions	10
Tumours modulate the systemic vascular response to anti‐angiogenic therapy	9
Serum biomarkers of isoniazid‐induced liver injury: Aminotransferases are insufficient, and OPN, L‐FABP and HMGB1 can be promising novel biomarkers	9
Environmental Aromatic Amine Induces Pulmonary Arterial Hypertension Associated With Estrogen Signaling and Serpine1	9
The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells	9
Toxicity evaluation of main zopiclone impurities based on quantitative structure–activity relationship models and in vitro tests	9
Hepatotoxicity of cantharidin is associated with the altered bile acid metabolism	9
Cigarette smoke interacts with amiodarone toxicity in Saccharomyces cerevisiae	9
Assessment of commercial polymers with and without reactive groups using amino acid derivative reactivity assay based on both molar concentration approach and gravimetric approach	9
Colchicine disrupts bile acid metabolic homeostasis by affecting the enterohepatic circulation in mice	9
In silico prediction of ocular toxicity of compounds using explainable machine learning and deep learning approaches	9
Glycyrrhetinic acid ameliorates diosbulbin B‐induced hepatotoxicity in mice by modulating metabolic activation of diosbulbin B	9
Issue Information	9
A development of a graph‐based ensemble machine learning model for skin sensitization hazard and potency assessment	9
Antioxidant dihydrolipolic acid protects against in vitro aluminum‐induced toxicity	8
Disruption of neurosteroid synthesis and release by tris(2,3‐dibromopropyl)isocyanurate in primary mouse cortical astrocytes in vitro	8
Safety Assessment of Butyric Acid‐Rich Triglyceride Oil: A Novel Palatable Formulation of Butyrate for the Pediatric Population	8
Liquiritin alleviates alpha‐naphthylisothiocyanate‐induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway	8
Structural binding perspectives of common plasticizers and a flame retardant, BDE‐153, against thyroxine‐binding globulin: potential for endocrine disruption	8
Anti‐Candida activity and in vitro toxicity screening of antifungals complexed with β‐cyclodextrin	8
Samarium Oxide Exposure Induces Toxicity and Cardiotoxicity in Zebrafish Embryos Through Apoptosis Pathway	8
Metabolomics approach to study in vivo toxicity of graphene oxide nanosheets	8
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CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan	8
Ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane: Toxicological effects on marine biota and human concerns	8
Issue Information	8
A proposed in vitro cytotoxicity test battery to detect and predict hepatotoxicity via multiple mechanisms and pathways: a minireview	8
Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro	8
Caenorhabditis elegans CYP33 Family in Eicosanoid Regulation, Xenobiotic Metabolism, Nanotoxicity and Spermatogenesis	8
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Organoids: A new approach in toxicity testing of nanotherapeutics	7
Toxicity of quantum dots on target organs and immune system	7
Evaluation of immunotoxicity of sodium metavanadate following drinking water exposure in female B6C3F1/N mice in a 28‐day study	7
Effect of renal tubular damage on non‐cancer mortality in the general Japanese population living in cadmium non‐polluted areas	7
Issue Information	7
Time‐course analysis of pulmonary inflammation induced by intratracheal instillation of nanosized crystalline silica particles in F344 rats	7
Toxicological effects of selenium nanoparticles in laboratory animals: A review	7
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Screening potential anaphylactoid components in vinpocetine injection using a high expression Mas‐related G‐protein‐coupled receptor X2 cell membrane chromatography	7
A novel alternative method for long‐term evaluation of male reproductive toxicity and its recovery using a pre‐pubertal mouse testis organ culture system	7
In silico prediction of chemical aquatic toxicity by multiple machine learning and deep learning approaches	7
Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells	7
Evidence for exposure biomarkers in dictamnine‐induced liver injury resulting from metabolic activation in vitro and in mice	7
Issue Information	7
Risk compounds, potential mechanisms and biomarkers of traditional Chinese medicine‐induced reproductive toxicity	7
General toxicity and genotoxicity of altertoxin I: A novel 28‐day multiendpoint assessment in male Sprague–Dawley rats	6
Euxanthone inhibits lipopolysaccharide‐induced injury, inflammatory response, and MUC5AC hypersecretion in human airway epithelial cells by the TLR4/MyD88 pathway	6
Non‐clinical safety evaluation of Yongdamsagan‐tang water extract: A 13‐week subchronic oral toxicity study in Sprague Dawley rats	6
Physiologically‐based pharmacokinetic model of in vitro porcine ear skin permeation for drug delivery research	6
Comparison of the sensitivity of histopathological and immunohistochemical analyses and blood hormone levels for early detection of antithyroid effects in rats treated with thyroid peroxidase inhibito	6
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mtDNA amplifies beryllium sulfate‐induced inflammatory responses via the cGAS‐STING pathway in 16HBE cells	6
Oral exposure to citrinin significantly exacerbates the pathophysiology of a mouse model of imiquimod‐induced psoriasis via direct activation of dendritic cell	6
Thyroid Endocrine Disrupting Potential of Fluoxetine in Zebrafish Larvae	6
Exposure to thiourea during the early stages of development impedes the formation of the swim bladder in zebrafish larvae	6
In vitro exposure of porcine spermatozoa to methylparaben, and propylparaben, alone or in combination adversely affects sperm quality	6
90‐day oral toxicity study in rats of a protein‐rich powder derived fromXanthobactersp. SoF1	6
Crotalus atrox venom‐induced cellular toxicity: Early wound progression involves reactive oxygen species	6
Methylglyoxal‐induced neurotoxic effects in primary neuronal‐like cells transdifferentiated from human mesenchymal stem cells: Impact of low concentrations	6
Disruption of vitamin A homeostasis by the biocide tetrakis(hydroxymethyl) phosphonium sulphate in pregnant rabbits	6
Toxicology and safety study of L‐tryptophan and its impurities for use in broiler feed	6
Epigenetic alternations in the SYP and DLG4 genes due to low‐level methylmercury exposure during neuronal differentiation in vitro	6
Developmental and reproductive toxicity hazard characterization of 2‐amino‐2‐methyl‐1‐propanol (AMP)	6
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Influence of systemic copper toxicity on early development and metamorphosis in Xenopus laevis	5
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Human health risk of mercury in street dust: A case study of children in the vicinity of compact fluorescence lamp factory, Hanoi, Vietnam	5
Arsenic‐Induced Inflammatory Response via ROS‐Dependent Activation of ERK/NF‐kB Signaling Pathways: Protective Role of Natural Polyphenol Tannic Acid	5
The apoptosis induced by CdTe quantum dots through the mitochondrial pathway in dorsal root ganglion cell line ND7/23	5
Fraxetin suppresses reactive oxygen species‐dependent autophagy by the PI3K/Akt pathway to inhibit isoflurane‐induced neurotoxicity in hippocampal neuronal cells	5
Physiologically based pharmacokinetic modeling and simulation of cannabinoids in human plasma and tissues	5
Liver‐specific decrease in Tff3 gene expression in infant mice perinatally exposed to 2,3,7,8‐tetrabromodibenzofuran or 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin	5
Endogenous humoral determinants of vascular endothelial dysfunction as triggers of acute poisoning complications	5

Characterisation of ChE in Solea solea and exposure of isoflavones in juveniles of commercial flatfish (Solea solea and Solea senegalensis)	5
Derivation of occupational exposure limits: Differences in methods and protection levels	5
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The Role of CXCL13 in GC‐1 Cell Cycle Arrest Induced by Titanium Dioxide Nanoparticles Through JAK2/STAT3 Signaling Pathway	5
Oxidative DNA damage contributes to usnic acid‐induced toxicity in human induced pluripotent stem cell‐derived hepatocytes	5
A novel strategy for the study on molecular mechanism of prostate injury induced by 4,4′‐sulfonyldiphenol based on network toxicology analysis	5
In silico analysis of endocrine‐disrupting potential of triclosan, bisphenol A, and their analogs and derivatives	5
Issue Information	5
Evaluation of skin sensitization induced by four ionic liquids	5
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Tumors modulate fenestrated vascular beds and host endocrine status	5
Subchronic toxicity evaluation of Huobahuagen extract and plasma metabolic profiling analysis combined with conventional pathology methods	5
Nonclinical safety and immunogenicity assessment of a combined DTacP vaccine in animal models	5
Particle surface functionalization affects mechanism of endocytosis and adverse effects of silver nanoparticles in mammalian kidney cells	5
The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity	5
CdTe quantum dots trigger oxidative stress and endoplasmic reticulum stress‐induced apoptosis and autophagy in rat Schwann cell line RSC96	5
Issue Information	5