OOIR: Observatory of International Research

Papers

(The TQCC of Immunologic Research is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Somatic hypermutation defects in two adult hyper immunoglobulin M patients	82
Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance	72
Laboratory and clinical practices in antinuclear antibody detection and related antigens: recommendations from a Spanish multicentre survey	55
Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis	50
Belimumab 10 years later: how drug positioning has changed	48
The cGAS-STING axis: a comprehensive review from immune defense to disease pathogenesis	41
PS77: a novel peptide with α-helical structure for targeted anti-inflammatory therapy in biomaterials design	33
Rapid generation of an RBL cellular model to study proteins that cause allergenic reactions in vitro	31
Quantitative evaluation of citrullinated fibrinogen for detection of neutrophil extracellular traps	30
Rubella-associated granuloma in a patient with a compound heterozygous RAG1 defect and review of the literature	28
Role of booster with BNT162b2 mRNA in SARS-CoV-2 vaccination in patients with rheumatoid arthritis	28
MiR-29a-3p negatively regulates circulating Tfh memory cells in patients with Graves’ disease by targeting ICOS	28
A case of atypical infantile de novo antiphospholipid syndrome presenting with neonatal ischemic stroke without any triggering risk factors as a “second hit” and review of the literature	27
RNA-based cancer vaccines: mechanisms, clinical progress, and translational challenges	27
Mitochondrial sirtuins 3, 4 and 5 in patients with psoriasis	23
ANCA detection with solid phase chemiluminescence assay: diagnostic and severity association in vasculitis	23
Genomic and clinical characterization of adult CVID patients: results from a single-centre turkish cohort	22
Clinical relevance and frequency of cytoplasmic patterns observed in ANA-Hep-2: experience of Cairo University Hospitals	22
A ubiquitin–proteasome system-related signature to predict prognosis, immune infiltration, and therapy efficacy for breast cancer	22
Multi-class machine learning-based classification of SCID-related genetic variants	21
[Cuproptosis-related immune gene signature predicts clinical benefits from anti-PD-1/PD-L1 therapy in non-small-cell lung cancer	20
Lipocalin 2—not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials	20
Myeloid inflammation thresholds stratify mortality risk in early-stage cardiovascular-kidney-metabolic syndrome: MLR-driven findings from NHANES	19
The double-edged sword of PI3Kδ pathway-related immune dysregulation: insights from two case reports	18
Immunomodulatory activities of carbon quantum dots on the primary macrophages and whole splenocytes	18

T cell receptor clonotype in tumor microenvironment contributes to intratumoral signaling network in patients with colorectal cancer	17
Semaphorin 3 a restores the ability of type 1 regulatory T cells to suppress food allergy	17
Correction: Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor	16
Pan-genome and reverse vaccinology approaches to design multi-epitope vaccine against Epstein-Barr virus associated with colorectal cancer	16
The expression of CD86 in CD3+CD56+ NKT cells is associated with the occurrence and prognosis of sepsis-associated encephalopathy in sepsis patients: a prospective observational cohort study	15
Clinical and molecular profile of 20 patients with DOCK8 deficiency—a single-center experience from Southern India	15
Tryptanthrin attenuates TLR3-mediated STAT1 activation in THP-1 cells	14
Hypermethylation of lysosomal-associated genes LAMP1 and LAMP2 compromises lysosome function in patients with acute lymphoblastic leukemia	14
Association of IL-23R and IL-10 variations with Behçet disease: a genetic analysis study	14
Juvenile dermatomyositis associated with autoantibodies to small ubiquitin-like modifier activating enzyme: a report of 4 cases from North India and a review of literature	14
Thyroid receptor β might be responsible for breast cancer associated with Hashimoto’s thyroiditis: a new insight into pathogenesis	13
A patient with RFX5 variant causing an expression defect in both HLA ABC and HLA DR	13
Role of the basophil activation test in the diagnosis and management of immediate drug reaction to injectable growth hormone preparation: a case report	13
Case report: Synergistic defects of CASP10 and BTK leading to autoimmune lymphoproliferative syndrome type IIa, complicated by severe hemophagocytic lymphohistiocytosis	13
Potential therapeutic strategies for myocardial infarction: the role of Toll-like receptors	13
miR-141-3p attenuates inflammation and oxidative stress–induced pulmonary fibrosis in ARDS via the Keap1/Nrf2/ARE signaling pathway	13
Efficacy and safety of IL-23 inhibitors in the treatment of psoriatic arthritis: a meta-analysis based on randomized controlled trials	13
Dominance and improved survivability of human γδT17 cell subset aggravates the immunopathogenesis of pemphigus vulgaris	13
Pediatric selective IgM deficiency: clinical features and a preliminary risk index for immunoglobulin replacement therapy	12
Melatonin: a potential therapeutic approach for the management of primary Sjögren’s syndrome	12
The urease E subunit vaccine stimulate the immune response versus Helicobacter pylori in animal model	12
Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages	12
Impaired inducibility of immune regulatory capacity of peripheral B cells of patients with recurrent pregnancy loss	11
Extracellular vesicle–encapsulated miR-10a-5p derived from MDSCs restrains germinal center B cells in experimental Sjögren’s syndrome	11
Translational and structural vaccinomics approach to design a multi-epitope vaccine against NOL4 autologous antigen of small cell lung cancer	11
Post-translational modification in the pathogenesis of vitiligo	11
Comparison of artificial intelligence applications and commercial system performances using selected ANA IIF images	10
High mobility group box 1 (HMGB1) inhibition attenuates lipopolysaccharide-induced cognitive dysfunction and sickness-like behavior in mice	10
Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research	10
Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response	10
Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial	10
Sex-related differences in cell-free DNA and neutrophil extracellular traps in patients with hematologic malignancies	10
Increased synthesis and intestinal expression of IL-39 in patients with inflammatory bowel disease	9
Reactivity of DENV-positive sera against recombinant envelope proteins produced in bacteria and eukaryotic cells	9
Coexistence of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and IgA nephropathy	9
Current genetic defects in common variable immunodeficiency patients on the geography between Europe and Asia: a single-center experience	9
Retinoic acid increases the cellular cholesterol predominantly in a mTOR-independent manner	9
Immunomodulatory effects of alexidine dihydrochloride on mammalian macrophages through the modulation of the JNK pathway	9
Amphibian cellular immune response to chytridiomycosis at metamorphic climax	9
Insights into inflammasome regulation: cellular, molecular, and pathogenic control of inflammasome activation	9
SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study	8
DMRT3-mediated lncRNA OIP5-AS1 promotes the pyroptosis of bronchial epithelial cells by binding with EIF4A3 to enhance YAP mRNA stability	8
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis	8
Mass cytometry revealed the circulating immune cell landscape across different Suzuki stages of Moyamoya disease	8
FOXO1 contributes to cigarette smoke condensate–induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway	8
mTOR-mediated differentiation and maintenance of suppressive T cells at the center stage of IPEX treatment	8
Predictive biomarkers of response to tocilizumab in giant cell arteritis (GCA): correlations with imaging activity	8
Regnase-1 regulates inflammation in T cells of ankylosing spondylitis through the TRAF6	8
Efficacy and safety of natural killer cell therapy for the treatment of advanced non-small cell lung cancer: A meta-analysis and systematic review	8
Integrative bioinformatics and experimental analyses identify U2SURP as a novel lactylation-related prognostic signature in esophageal carcinoma	8

Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation	7
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis	7
An association study on the risk, glucocorticoids effectiveness, and prognosis of systemic lupus erythematosus: insight from mitochondrial DNA copy number	7
Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis	7
Somatic mosaicism of CYBB causing atypical CGD with inflammatory symptoms	7
Autophagic reprogramming of bone marrow–derived macrophages	7
Anti-complement factor H (CFH) autoantibodies could delay pristane-induced lupus nephritis	7
Disease activity and immune disbalance are key drivers of infections in patients with idiopathic inflammatory myopathies: results from the MYOTReCSZ cohort	7
Utility of simultaneous quantification of TREC/KREC in patients with common variable immunodeficiency phenotype: an observational study from North India	7
Conventional Tregs in treatment-naïve rheumatoid arthritis are deficient in suppressive function with an increase in percentage of CXCR3 and CCR6 expressing Tregs	7
Fructus lycii oligosaccharide alleviates acute liver injury via PI3K/Akt/mTOR pathway	7
New-onset eosinophilic granulomatosis with polyangiitis in 2 patients during treatment with IL-5 pathway inhibitors	7
The effect of the BNT162b2 vaccine on antinuclear antibody and antiphospholipid antibody levels	7
Piceatannol improves autoimmune hepatitis by inhibiting the immune activities of T cells and macrophages through binding with c-Jun	6
Highlighting the role of CD44 in cervical cancer progression: immunotherapy’s potential in inhibiting metastasis and chemoresistance	6
Vitamin D receptor gene polymorphisms are associated with the risk and features of myasthenia gravis in the Han Chinese population	6
Polyethylene glycol and immunology: aspects of allergic reactions and their mechanisms, as well as ways to prevent them in clinical practice	6
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice	6
Regarding the significance of anti-COVID-IgA antibody response in COVID-19 breakthrough infection	6
The function of CD8 + T cells in the absence of MHC-I in target cells: what to learn from the deficiency of MHC-I expression in humans	6
The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach	6
Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions	6
Thymic tuft cells: potential “regulators” of non-mucosal tissue development and immune response	6
Correction to: A latent pathogen infection classification system that would significantly increase healthcare safety	6
The alterations of cerebrospinal fluid TNF-alpha and TGF-beta2 levels in early relapsing–remitting multiple sclerosis	6
The impact of neddylation on prognosis in the immune microenvironment of neuroblastoma: a single-cell transcriptomic analysis	6
CCR2+TREM-1+ monocytes promote natural killer T cell dysfunction contributing towards HBV disease progression	6
Autoimmune lymphoproliferative syndrome (ALPS) due to a novel dominant negative germline mutation in the FAS gene	6
Investigation of T lymphocyte subsets in children with Mycoplasma pneumoniae pneumonia	6
HLA-E-expressing macrophage polarization and increased NKG2A/CD94 expression in adult-onset Still’s disease	6
tRNA-derived fragments: biomarkers and therapeutic targets in autoimmune diseases	5
Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria	5
HBV infection upregulates GP73 expression to promote liver fibrosis by enhancing ER stress via the Smad2 pathway	5
Rational design of multi-epitope-based vaccine by exploring all dengue virus serotypes proteome: an immunoinformatic approach	5
STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel disease	5
Correction to: The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages	5
APLAID complicated with arrhythmogenic dilated cardiomyopathy caused by a novel PLCG2 variant	5
Immunological and clinical characteristics in a cohort of Colombian pediatric patients with 22q11.2 deletion	5
Harmonization of ANA testing challenge: quantification strategy to accurately predict end-point titers avoiding serial dilution	5
Sustainability, intelligence, and more immunology: time to get back to the future!	5
SPDYC serves as a prognostic biomarker related to lipid metabolism and the immune microenvironment in breast cancer	5
The mechanism of p38 MAPK, NF-κB, and IL-6 in T-2 toxin and/or selenium deficiency induced spleen injury	5
Clinical profile and management of pediatric hereditary angioedema in resource-constrained settings: our experience from a single centre in North India	5
A latent pathogen infection classification system that would significantly increase healthcare safety	5
Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia/reperfusion-induced lung and intestinal injury	5
Role of IL-22 in intestinal microenvironment and potential targeted therapy through diet	5
Monogenic inborn errors of immunity in autoimmune disorders	5
Versatile roles for neutrophil proteinase 3 in hematopoiesis and inflammation	5
Dexmedetomidine protects against postoperative neurocognitive disorder by mitigating mitochondrial dysfunction through regulating the IP3R-GRP75-VDAC1 complex-mediated calcium transport	5
Involvement of gut microbiota in multiple sclerosis—review of a new pathophysiological hypothesis and potential treatment target	5
Lactylation-related multigene signature in multiple myeloma: integrated prognostic stratification, immune landscape profiling, and therapeutic guidance	5
Analysis of binding and authentic virus-neutralizing activities of immune sera induced by various monkeypox virus antigens	5
SAPHO syndrome after COVID-19 vaccination complicated with thyroid function abnormalities: a case report and literature review	5
Clinical features and potential markers of disease in idiopathic non-histaminergic angioedema, a real-life study	5
OGT promotes the ferroptosis of chondrocytes in osteoarthritis development via O-GlcNAcylation modification of ACSF2	5
Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study	5
ASIA syndrome after BNT162b2 vaccination: Is it a distinct rheumatoid arthritis phenotype?	5
Glutaminase as a metabolic checkpoint in NK cell cytotoxicity: mechanistic uncertainties and translational implications	5
The ability of inflammatory markers to recognize infection in cancer patients with fever at admission	5
Anti-inflammatory effects of 1,7-dihydroxy-3,4-dimethoxyxanthone through inhibition of M1-phenotype macrophages via arginine/mitochondrial axis	5
From immunosuppression to immune reprogramming: is triptolide a potential “immune reset” agent in autoimmune diseases?	5
Altered CD27-related T cell subsets reflect immune imbalance in systemic lupus erythematosus	5
Exploring the role of the Th9/IL-9 axis in atopic dermatitis: analysis of Th9 cells, PU.1 expression and serum IL-9 levels	5
Polymorphisms in STAT4 and PTPRC genes in rheumatoid arthritis: a Brazilian study and meta-analysis of susceptibility and TNFi response	5
Monophosphoryl lipid A as a co-adjuvant in methicillin-resistant Staphylococcus aureus vaccine development: improvement of immune responses in a mouse model of infection	5
Insights into the immunological description of cryoglobulins with regard to detection and characterization in Slovenian rheumatological patients	5
A novel loss of function mutation in the HAVCR2 gene in a patient diagnosed with Hodgkin’s lymphoma	5