OOIR: Observatory of International Research

Papers

(The median citation count of Archives of Pharmacal Research is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Ubiquitin–proteasome system (UPS) as a target for anticancer treatment	145
Phytochemistry and pharmacological activity of the genus artemisia	82
The pharmacological and biological roles of eriodictyol	75
Aldose Reductase: a cause and a potential target for the treatment of diabetic complications	60
Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases	60
Pathological angiogenesis and inflammation in tissues	60
Mechanisms of resistance to chemotherapy in non-small cell lung cancer	59
Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems	57
Pharmacological effects of harmine and its derivatives: a review	52
Skin barrier dysfunction and filaggrin	52
Overview of COVID-19 inflammatory pathogenesis from the therapeutic perspective	51
Biomedical features and therapeutic potential of rosmarinic acid	49
Astragalus polysaccharide: a review of its immunomodulatory effect	46
Small molecule tyrosine kinase inhibitors in glioblastoma	46
Empagliflozin alleviates neuronal apoptosis induced by cerebral ischemia/reperfusion injury through HIF-1α/VEGF signaling pathway	45
Phytochemical and pharmacological properties of Myristica fragrans Houtt.: an updated review	40
Ginkwanghols A and B, osteogenic coumaric acid-aliphatic alcohol hybrids from the leaves of Ginkgo biloba	39
Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes	36
The potential health benefits of the isoflavone glycoside genistin	35
Hydroxychloroquine and chloroquine: a potential and controversial treatment for COVID-19	35
A pursuit of Staphylococcus aureus continues: a role of persister cells	35
Role of specialized pro-resolving lipid mediators and their receptors in virus infection: a promising therapeutic strategy for SARS-CoV-2 cytokine storm	35
Flavonoids as therapeutic candidates for emotional disorders such as anxiety and depression	34
The role of mucosal barriers in human gut health	32
Emerging roles of ferroptosis in liver pathophysiology	32

Crosstalk between angiogenesis and immune regulation in the tumor microenvironment	32
Understanding of sarcopenia: from definition to therapeutic strategies	31
Recent insights on modulation of inflammasomes by adipokines: a critical event for the pathogenesis of obesity and metabolism-associated diseases	31
Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway	31
Role of autophagy in regulation of cancer cell death/apoptosis during anti-cancer therapy: focus on autophagy flux blockade	29
The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance	29
Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson’s disease: clues to early diagnosis and effective treatment	28
Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis	28
Role of mitochondrial dynamics and mitophagy of vascular smooth muscle cell proliferation and migration in progression of atherosclerosis	27
Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action	27
mRNA vaccines: the most recent clinical applications of synthetic mRNA	27
Fibroblast growth factor 2 exacerbates inflammation in adipocytes through NLRP3 inflammasome activation	26
Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells	26
Therapeutic effects of ginsenosides on breast cancer growth and metastasis	26
Pharmacokinetics of ginsenosides following repeated oral administration of red ginseng extract significantly differ between species of experimental animals	24
Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics	24
Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide	24
Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism	23
Evaluation and live monitoring of pH-responsive HSA-ZnO nanoparticles using a lung-on-a-chip model	23
3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase	23
Latest research progress on anticancer effect of baicalin and its aglycone baicalein	22
Curcumin derivatives for Type 2 Diabetes management and prevention of complications	22
New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)	21
The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance	21
LncRNA AIRN influences the proliferation and apoptosis of hepatocellular carcinoma cells by regulating STAT1 ubiquitination	21
Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides	21
Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives	20
Recent progress in development and applications of second near‐infrared (NIR-II) nanoprobes	20
NRF2 level is negatively correlated with TGF-β1-induced lung cancer motility and migration via NOX4-ROS signaling	20
White matter and neurological disorders	20
Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells	19
Qi-activating quercetin alleviates mitochondrial dysfunction and neuroinflammation in vivo and in vitro	19
Comparative evaluation of bioactive phytochemicals in Spinacia oleracea cultivated under greenhouse and open field conditions	19
ABCB1 c.2677G>T/c.3435C>T diplotype increases the early-phase oral absorption of losartan	19
Ferulic acid protects cardiomyocytes from TNF-α/cycloheximide-induced apoptosis by regulating autophagy	19
Antimicrobial compounds from marine actinomycetes	18
Antibody–drug conjugates and bispecific antibodies targeting cancers: applications of click chemistry	18
Protective effect of quercetin against myocardial ischemia as a Ca2+ channel inhibitor: involvement of inhibiting contractility and Ca2+ influx via L-type Ca2+ channels	17
Targeting fatty acid metabolism for fibrotic disorders	17
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells	17
Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway	17
Structure elucidation of small organic molecules by contemporary computational chemistry methods	17
Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders	17
Fucoidan inhibits LPS-induced acute lung injury in mice through regulating GSK-3β-Nrf2 signaling pathway	16
Exosomal microRNAs as diagnostic and therapeutic biomarkers in non-malignant liver diseases	16
New tricyclic systems as photosensitizers towards triple negative breast cancer cells	16
Transcriptional suppression of androgen receptor by 18β-glycyrrhetinic acid in LNCaP human prostate cancer cells	16
Mechanistic diversity involved in the desensitization of G protein-coupled receptors	16
Physiologically based pharmacokinetic (PBPK) modeling of meloxicam in different CYP2C9 genotypes	16
Indirubin-3-monoxime and thymoquinone exhibit synergistic efficacy as therapeutic combination in in-vitro and in-vivo models of Lung cancer	15

Hyperthermal paclitaxel-bound albumin nanoparticles co-loaded with indocyanine green and hyaluronidase for treating pancreatic cancers	15
COVID-19 and pulmonary fibrosis: therapeutics in clinical trials, repurposing, and potential development	15
Peroxisome proliferator-activated receptor gamma: a novel therapeutic target for cognitive impairment and mood disorders that functions via the regulation of adult neurogenesis	15
Applications of deep eutectic solvents to quantitative analyses of pharmaceuticals and pesticides in various matrices: a brief review	15
β-Sitosterol attenuates liver injury in a rat model of chronic alcohol intake	15
Recent progresses in marine microbial-derived antiviral natural products	15
Function and therapeutic development of exosomes for cancer therapy	15
Pharmacology and adverse effects of new psychoactive substances: synthetic cannabinoid receptor agonists	14
Inhibition of PTP1B by farnesylated 2-arylbenzofurans isolated from Morus alba root bark: unraveling the mechanism of inhibition based on in vitro and in silico studies	14
Treatments of inflammatory bowel disease toward personalized medicine	14
Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation	14
Sestrin2 induction contributes to anti-inflammatory responses and cell survival by globular adiponectin in macrophages	14
Therapeutic effects of histone deacetylase inhibitors on heart disease	14
Effects of paroxetine on the pharmacokinetics of atomoxetine and its metabolites in different CYP2D6 genotypes	13
Many faces of the GPCR-arrestin interaction	13
Phytochemicals against anti‐diabetic complications: targeting the advanced glycation end product signaling pathway	13
Beta resorcylic acid lactones (RALs) from fungi: chemistry, biology, and biosynthesis	13
Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway	13
Physiologically based pharmacokinetic modeling of candesartan related to CYP2C9 genetic polymorphism in adult and pediatric patients	13
The essential role of TAZ in normal tissue homeostasis	12
Physiologically based pharmacokinetic (PBPK) modelling of tamsulosin related to CYP2D6*10 allele	12
Advances in plant-derived natural products for antitumor immunotherapy	12
Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities	12
Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling	12
Activation of β2 adrenergic receptor signaling modulates inflammation: a target limiting the progression of kidney diseases	12
CD48-expressing non-small-cell lung cancer cells are susceptible to natural killer cell–mediated cytotoxicity	12
Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism	12
Triterpenoids from Dysoxylum genus and their biological activities	12
In vitro modeling for inherited neurological diseases using induced pluripotent stem cells: from 2D to organoid	12
Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment	11
Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential	11
Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process	11
Nrf2 in adipocytes	11
Effects of CYP2C93 and 13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects	11
Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer	11
Relationship between plasma exposure of zolpidem and CYP2D6 genotype in healthy Korean subjects	11
Isoindolin-1-ones from the stems of Nicotiana tabacum and their antiviral activities	11
Molecular epigenetic dynamics in breast carcinogenesis	10
PBN inhibits a detrimental effect of methamphetamine on brain endothelial cells by alleviating the generation of reactive oxygen species	10
ACY-241, an HDAC6 inhibitor, overcomes erlotinib resistance in human pancreatic cancer cells by inducing autophagy	10
Bioactive natural products from the genus Salinospora: a review	10
Brain energy metabolism and multiple sclerosis: progress and prospects	9
Repositioning medication for cardiovascular and cerebrovascular disease to delay the onset and prevent progression of Alzheimer’s disease	9
Methamphetamine-induced dopaminergic neurotoxicity as a model of Parkinson’s disease	9
Overexpressing microRNA-203 alleviates myocardial infarction via interacting with long non-coding RNA MIAT and mitochondrial coupling factor 6	9
Trehalose ameliorates prodromal non-motor deficits and aberrant protein accumulation in a rotenone-induced mouse model of Parkinson’s disease	9
Development of JAK inhibitors for the treatment of immune-mediated diseases: kinase-targeted inhibitors and pseudokinase-targeted inhibitors	9
Canonical transient receptor potential channels and their modulators: biology, pharmacology and therapeutic potentials	8
miR-139-5p promotes neovascularization in diabetic retinopathy by regulating the phosphatase and tensin homolog	8
Structural feature of TRAFs, their related human diseases and therapeutic intervention	8
Inhibition of hyaluronan synthesis by 4-methylumbelliferone ameliorates non-alcoholic steatohepatitis in choline-deficient l-amino acid-defined diet-induced murine model	8
Sesamolin promotes cytolysis and migration activity of natural killer cells via dendritic cells	8
Grape seed proanthocyanidins protect retinal ganglion cells by inhibiting oxidative stress and mitochondrial alteration	8
Clerodane furanoditerpenoids from the stems of Tinospora sinensis	8
Characteristics of Korean patients with methamphetamine use disorder based on the quantitative analysis of methamphetamine and amphetamine in hair	8
Alcoholic liver disease: a new insight into the pathogenesis of liver disease	8
Protective effect of lncRNA CRNDE on myocardial cell apoptosis in heart failure by regulating HMGB1 cytoplasm translocation through PARP-1	8
Effects of phytoestrogens on reproductive organ health	8
Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities	8
Physiologically based pharmacokinetic modelling to predict the pharmacokinetics of metoprolol in different CYP2D6 genotypes	8