OOIR: Observatory of International Research

Papers

(The median citation count of Archives of Pharmacal Research is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Mouse models of nonalcoholic steatohepatitis and their application to new drug development	119
Evaluation of bone health and fracture risk in type 2 diabetes: a network meta-analysis of anti-diabetic treatments versus placebo	100
Recent paclitaxel formulation strategies: expanding the therapeutic index by addressing biopharmaceutical and toxicity limitations	95
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation	83
Cinnamic acid attenuates Klebsiella pneumoniae virulence by suppressing capsule biosynthesis	69
Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities	68
Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy	66
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways	54
Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight	52
Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway	48
Germacrane and humulane sesquiterpenes from the roots and rhizomes of Valeriana officinalis var. latifolia and their anti-inflammatory and anti-influenza virus activities	48
Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin	45
Correction to: The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer	42
Retraction Note: Anti-inflammatory effect of atorvastatin on vascular reactivity and insulin resistance in fructose fed rats	41
Donepezil improves skeletal muscle insulin resistance in obese mice via the AMPK/FGF21-mediated suppression of inflammation and ferroptosis	39
Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions	37
Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration	37
PBPK modeling of the antidepressant doxepin incorporating CYP2D6 genotype for precision pharmacotherapy	34
Impact of binge drinking on alcoholic liver disease	33
Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes	33
Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis	32
Minor structural changes, major functional impacts: posttranslational modifications and drug targets	32
Non-alcoholic fatty liver disease and liver secretome	31
Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis	30
A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations	29

Tumor organoid platform design for drug response modeling: culture architecture, microenvironmental complexity, and AI-assisted readouts	29
The role and application of transcriptional repressors in cancer treatment	29
Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes	28
Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation	27
Tirzepatide mitigates atherosclerosis progression and modulates oxLDL-mediated proatherogenic effects in macrophages: evidence for M1/M2 homeostasis restoration	27
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2	25
Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions	25
Vitamin D remodels the tumor microenvironment to suppress gastric cancer progression through cancer-associated fibroblasts-secreted exosomal miR-378c targeting KDSR	25
Phytochemistry and pharmacology of plants in the genus Chaenomeles	24
Salvianolic acid A enhances Treg accumulation via the RUNX1/CBFβ/FOXP3 axis as a neuroprotective immunomodulator in ischemic stroke	24
Nanostructured branched Y-DNA promotes antitumor immunity through dual activation of cGAS/STING and TLR9	22
The inhibition of endothelial DLL4-NOTCH1 signaling by 2'-hydroxyflavanone enhances anti-PD-1 therapy in melanoma	22
Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway	22
M2 microglial exosomal miR-1949 ameliorates sepsis-associated encephalopathy through DKK1/Wnt/β-catenin-mediated microglial repolarization	22
Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer	22
Potential effects of a human milk oligosaccharide 6′-sialyllactose on angiotensin II-induced aortic aneurysm via p90RSK/TGF-β/SMAD2 signaling pathway	21
Immunosenescence and age-related immune cells: causes of age-related diseases	21
Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets	21
Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes	21
Ischemic stroke neuroprotection revisited: translational barriers and a phase-resolved, biomarker-anchored framework	20
Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects	20
New tricyclic systems as photosensitizers towards triple negative breast cancer cells	19
Natural compounds targeting inflammatory signaling and cell adhesion molecules in ischemic acute kidney injury	19
Integrative multi-omics analyses reveal nuclear noncoding RNA-mediated regulatory landscape in Alzheimer’s disease	18
Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer	18
Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review	18
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone	17
Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation	17
Advances and challenges of estrogen receptor-targeted agents in breast cancer	16
Cardiotoxicity linked to anticancer agents and cardioprotective strategy	16
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC	16
Advanced therapeutic strategies targeting microglia: beyond neuroinflammation	16
Mechanistic insights and emerging therapeutic strategies targeting endothelial dysfunction in cardiovascular diseases	15
Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes	15
Homoharringtonine inhibits growth and migration in non-small cell lung cancer via PDIA4-mediated modulation of autophagy and EMT	15
PF protects retinal pigment epithelial cells from oxidative injury by enhancing mitophagy through a CUL3-dependent AMPK/ULK1 pathway	14
Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment	14
Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism	14
Activation of cryptic biosynthetic pathways in Saccharopolyspora spinosa through deletion of the spinosyn gene cluster: induction of cryptic and bioactive natural products	14
Evaluating the clinical effects of GLP-1 receptor agonists for Alzheimer's and Parkinson's diseases using minimal clinically important difference: systematic review and meta-analysis	14
Biodegradable gelatin methacryloyl microneedles: a new paradigm in transdermal drug delivery	14
Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment	14
Dual roles of myeloid-derived suppressor cells in various diseases: a review	13
Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways	13
Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies	13
PET tracer development for imaging α-synucleinopathies	13
cis-Clerodane-type diterpenoids from Tinospora crispa and their anticancer potential	13
Effects of CYP2D6*10 allele on the pharmacokinetics of tolperisone	13
E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice	12
Resmetirom, the first FDA-approved drug for MASH: From drug discovery and action mechanisms to clinical trials	12

Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential	12
Curcumin monoglucuronide protects cartilage from progressive degeneration by blocking MMP-13	12
Insights into biological activities profile of gingerols and shogaols for potential pharmacological applications	12
Mechanisms and structure–activity relationship of hypolipidemic effects of polysaccharides from natural resources: a review	12
Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review	12
Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals	11
Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function	11
Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis	11
Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides	11
P7C3 alleviates hepatic fibrosis via targeting eIF4A1-mediated protein translation and autophagy in hepatic stellate cells	11
Effects of CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy subjects	10
Exploring NNMT: from metabolic pathways to therapeutic targets	10
Cartilage extracellular matrix regeneration with 10-gingerol via KEAP1-NRF2-ARE axis for osteoarthritis therapy	10
Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments	10
Modulating versatile pathways using a cleavable PEG shell and EGFR-targeted nanoparticles to deliver CRISPR-Cas9 and docetaxel for triple-negative breast cancer inhibition	10
Comparative evaluation of bioactive phytochemicals in Spinacia oleracea cultivated under greenhouse and open field conditions	10
Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway	10
Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells	10
Histone lactylation in gastrointestinal cancers: developing immunotherapeutic drugs targeting epigenetics	10
Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management	10
Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson’s disease treatment	10
Physiologically based pharmacokinetic (PBPK) modeling of gliclazide for different genotypes of CYP2C9 and CYP2C19	10
Enhancer regulation in cancer: from epigenetics to m6A RNA modification	10
Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs	10
Site-selective addition of succinimide motif through nitro-assisted C–H functionalization of (hetero) arenes under rhodium catalysis	10
Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms	9
Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/FOXO3 signaling pathways	9
Silybin inhibits succinate production and secretion in hepatocytes to reverse liver fibrosis	9
Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins	9
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis	9
Neuroprotective effects of taurine in a rodent model of parkinson’s disease involve modulating astrocyte-mediated inflammation	9
Antitumor activity of Polygonatum sibiricum polysaccharides	9
Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice	9
JAK2/STAT3-dependent regulation of MDM4/MDM2-p53 signaling in methotrexate-induced ferroptosis and nephrotoxicity	8
Retraction Note: MiR-338-5p ameliorates pathological cardiac hypertrophy by targeting CAMKIIδ	8
Targeting dysregulated lipid metabolism in the tumor microenvironment	8
Prediction of human pharmacokinetic parameters incorporating SMILES information	8
C-phycocyanin reinforces autophagy to block pulmonary fibrogenesis by inhibiting lncIAPF biogenesis	8
Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway	8
Inhibition of RBPJ transcription complex promotes IL-17 and IFN-γ secretion by CD4⁺ T cells in hepatocellular carcinoma	8
Pharmacological targeting of HDAC/BET pathway enhances 5-FU efficacy in esophageal squamous cancer cells	8