OOIR: Observatory of International Research

Papers

(The median citation count of Archives of Pharmacal Research is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process	210
Evaluation of bone health and fracture risk in type 2 diabetes: a network meta-analysis of anti-diabetic treatments versus placebo	158
Mouse models of nonalcoholic steatohepatitis and their application to new drug development	80
CD48-expressing non-small-cell lung cancer cells are susceptible to natural killer cell–mediated cytotoxicity	75
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation	64
Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy	58
Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities	55
Correction to: The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer	54
Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway	54
Germacrane and humulane sesquiterpenes from the roots and rhizomes of Valeriana officinalis var. latifolia and their anti-inflammatory and anti-influenza virus activities	50
Impact of binge drinking on alcoholic liver disease	47
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways	43
Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin	40
Retraction Note: Anti-inflammatory effect of atorvastatin on vascular reactivity and insulin resistance in fructose fed rats	40
Advances in plant-derived natural products for antitumor immunotherapy	38
Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight	37
Donepezil improves skeletal muscle insulin resistance in obese mice via the AMPK/FGF21-mediated suppression of inflammation and ferroptosis	37
Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions	36
Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration	36
The role and application of transcriptional repressors in cancer treatment	33
Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis	33
Minor structural changes, major functional impacts: posttranslational modifications and drug targets	32
Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis	32
Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes	31
Non-alcoholic fatty liver disease and liver secretome	31

A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations	30
Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes	28
Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation	27
Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway	26
Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer	25
Triterpenoids from Dysoxylum genus and their biological activities	25
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2	24
Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions	24
Phytochemistry and pharmacology of plants in the genus Chaenomeles	23
Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections	23
The inhibition of endothelial DLL4-NOTCH1 signaling by 2'-hydroxyflavanone enhances anti-PD-1 therapy in melanoma	23
Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer	23
The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model	22
Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway	22
Immunosenescence and age-related immune cells: causes of age-related diseases	22
Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers	21
Correction to: Site-selective and metal-free C–H nitration of biologically relevant N-heterocycles	20
Potential effects of a human milk oligosaccharide 6′-sialyllactose on angiotensin II-induced aortic aneurysm via p90RSK/TGF-β/SMAD2 signaling pathway	20
Effects of CYP2C93 and 13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects	20
Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets	20
Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review	19
Immune-related pathogenesis and therapeutic strategies of nonalcoholic steatohepatitis	19
Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes	19
New tricyclic systems as photosensitizers towards triple negative breast cancer cells	19
Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects	19
Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation	19
Biomedical features and therapeutic potential of rosmarinic acid	19
Biodegradable gelatin methacryloyl microneedles: a new paradigm in transdermal drug delivery	18
Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes	18
Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer	18
Cardiotoxicity linked to anticancer agents and cardioprotective strategy	18
New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)	18
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone	18
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC	18
Advanced therapeutic strategies targeting microglia: beyond neuroinflammation	18
Activation of cryptic biosynthetic pathways in Saccharopolyspora spinosa through deletion of the spinosyn gene cluster: induction of cryptic and bioactive natural products	17
Mechanistic insights and emerging therapeutic strategies targeting endothelial dysfunction in cardiovascular diseases	17
Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment	17
Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism	17
Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment	16
Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism	16
Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies	15
Insights into biological activities profile of gingerols and shogaols for potential pharmacological applications	15
PET tracer development for imaging α-synucleinopathies	14
Physiologically based pharmacokinetic modelling to predict the pharmacokinetics of metoprolol in different CYP2D6 genotypes	14
Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review	14
Effects of CYP2D6*10 allele on the pharmacokinetics of tolperisone	14
Dual roles of myeloid-derived suppressor cells in various diseases: a review	13
Curcumin monoglucuronide protects cartilage from progressive degeneration by blocking MMP-13	13
Resmetirom, the first FDA-approved drug for MASH: From drug discovery and action mechanisms to clinical trials	13

Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells	13
Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways	13
E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice	12
Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides	12
Physiologically based pharmacokinetic modeling of candesartan related to CYP2C9 genetic polymorphism in adult and pediatric patients	11
Latest research progress on anticancer effect of baicalin and its aglycone baicalein	11
Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals	11
Effects of CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy subjects	11
Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis	11
Physiologically based pharmacokinetic (PBPK) modeling of gliclazide for different genotypes of CYP2C9 and CYP2C19	11
Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function	11
Modulating versatile pathways using a cleavable PEG shell and EGFR-targeted nanoparticles to deliver CRISPR-Cas9 and docetaxel for triple-negative breast cancer inhibition	10
Enhancer regulation in cancer: from epigenetics to m6A RNA modification	10
Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways	10
Role of mitochondrial dynamics and mitophagy of vascular smooth muscle cell proliferation and migration in progression of atherosclerosis	10
Exploring NNMT: from metabolic pathways to therapeutic targets	10
Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells	10
Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice	10
Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs	10
Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway	10
Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments	10
Antitumor activity of Polygonatum sibiricum polysaccharides	10
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis	9
Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson’s disease treatment	9
Dual inhibitors of P-glycoprotein and breast cancer resistance protein for overcoming the blood–brain barrier: in silico discovery and preclinical evaluation	9
Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management	9
Comparative evaluation of bioactive phytochemicals in Spinacia oleracea cultivated under greenhouse and open field conditions	9
Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins	9
Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells	9
Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/FOXO3 signaling pathways	9
mRNA vaccines: the most recent clinical applications of synthetic mRNA	9
Retraction Note: MiR-338-5p ameliorates pathological cardiac hypertrophy by targeting CAMKIIδ	9
Prediction of human pharmacokinetic parameters incorporating SMILES information	8
Associations between the gut microbiota and the metabolism rate of tacrolimus in kidney transplant recipients during the early posttransplant period	8
Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway	8
Physiologically based pharmacokinetic (PBPK) modeling of flurbiprofen in different CYP2C9 genotypes	8
Targeting dysregulated lipid metabolism in the tumor microenvironment	8
Neuroprotective effects of taurine in a rodent model of parkinson’s disease involve modulating astrocyte-mediated inflammation	8
C-phycocyanin reinforces autophagy to block pulmonary fibrogenesis by inhibiting lncIAPF biogenesis	8
Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms	8
Silybin inhibits succinate production and secretion in hepatocytes to reverse liver fibrosis	8