OOIR: Observatory of International Research

Papers

(The median citation count of Archives of Pharmacal Research is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Recent paclitaxel formulation strategies: expanding the therapeutic index by addressing biopharmaceutical and toxicity limitations	270
Mouse models of nonalcoholic steatohepatitis and their application to new drug development	107
Evaluation of bone health and fracture risk in type 2 diabetes: a network meta-analysis of anti-diabetic treatments versus placebo	88
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation	88
Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy	80
Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities	66
Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin	63
Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration	62
Correction to: The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer	61
Impact of binge drinking on alcoholic liver disease	58
Donepezil improves skeletal muscle insulin resistance in obese mice via the AMPK/FGF21-mediated suppression of inflammation and ferroptosis	49
Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway	45
PBPK modeling of the antidepressant doxepin incorporating CYP2D6 genotype for precision pharmacotherapy	45
Germacrane and humulane sesquiterpenes from the roots and rhizomes of Valeriana officinalis var. latifolia and their anti-inflammatory and anti-influenza virus activities	45
Retraction Note: Anti-inflammatory effect of atorvastatin on vascular reactivity and insulin resistance in fructose fed rats	44
Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight	43
Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions	42
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways	42
Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis	38
Minor structural changes, major functional impacts: posttranslational modifications and drug targets	36
The role and application of transcriptional repressors in cancer treatment	35
Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis	34
Non-alcoholic fatty liver disease and liver secretome	33
A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations	32
Tirzepatide mitigates atherosclerosis progression and modulates oxLDL-mediated proatherogenic effects in macrophages: evidence for M1/M2 homeostasis restoration	31

Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes	31
Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes	28
Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation	27
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2	27
Salvianolic acid A enhances Treg accumulation via the RUNX1/CBFβ/FOXP3 axis as a neuroprotective immunomodulator in ischemic stroke	26
The inhibition of endothelial DLL4-NOTCH1 signaling by 2'-hydroxyflavanone enhances anti-PD-1 therapy in melanoma	26
Phytochemistry and pharmacology of plants in the genus Chaenomeles	26
Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions	26
Immunosenescence and age-related immune cells: causes of age-related diseases	25
Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer	24
Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway	24
Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers	24
Potential effects of a human milk oligosaccharide 6′-sialyllactose on angiotensin II-induced aortic aneurysm via p90RSK/TGF-β/SMAD2 signaling pathway	23
Nanostructured branched Y-DNA promotes antitumor immunity through dual activation of cGAS/STING and TLR9	23
Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects	21
Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes	21
Ischemic stroke neuroprotection revisited: translational barriers and a phase-resolved, biomarker-anchored framework	21
Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets	20
Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer	20
Advances and challenges of estrogen receptor-targeted agents in breast cancer	19
Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review	19
Natural compounds targeting inflammatory signaling and cell adhesion molecules in ischemic acute kidney injury	19
New tricyclic systems as photosensitizers towards triple negative breast cancer cells	19
Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation	19
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC	18
Biodegradable gelatin methacryloyl microneedles: a new paradigm in transdermal drug delivery	18
Homoharringtonine inhibits growth and migration in non-small cell lung cancer via PDIA4-mediated modulation of autophagy and EMT	17
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone	16
Advanced therapeutic strategies targeting microglia: beyond neuroinflammation	16
Cardiotoxicity linked to anticancer agents and cardioprotective strategy	16
Mechanistic insights and emerging therapeutic strategies targeting endothelial dysfunction in cardiovascular diseases	15
Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment	15
Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes	15
Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism	15
Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment	15
Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism	15
Physiologically based pharmacokinetic modelling to predict the pharmacokinetics of metoprolol in different CYP2D6 genotypes	14
Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies	14
Mechanisms and structure–activity relationship of hypolipidemic effects of polysaccharides from natural resources: a review	14
Activation of cryptic biosynthetic pathways in Saccharopolyspora spinosa through deletion of the spinosyn gene cluster: induction of cryptic and bioactive natural products	14
Insights into biological activities profile of gingerols and shogaols for potential pharmacological applications	14
PF protects retinal pigment epithelial cells from oxidative injury by enhancing mitophagy through a CUL3-dependent AMPK/ULK1 pathway	14
Dual roles of myeloid-derived suppressor cells in various diseases: a review	13
Resmetirom, the first FDA-approved drug for MASH: From drug discovery and action mechanisms to clinical trials	13
cis-Clerodane-type diterpenoids from Tinospora crispa and their anticancer potential	13
Effects of CYP2D6*10 allele on the pharmacokinetics of tolperisone	13
E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice	12
Curcumin monoglucuronide protects cartilage from progressive degeneration by blocking MMP-13	12
PET tracer development for imaging α-synucleinopathies	12
Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides	12

Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review	12
Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals	12
Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways	12
Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway	11
P7C3 alleviates hepatic fibrosis via targeting eIF4A1-mediated protein translation and autophagy in hepatic stellate cells	11
Cartilage extracellular matrix regeneration with 10-gingerol via KEAP1-NRF2-ARE axis for osteoarthritis therapy	11
Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function	11
Modulating versatile pathways using a cleavable PEG shell and EGFR-targeted nanoparticles to deliver CRISPR-Cas9 and docetaxel for triple-negative breast cancer inhibition	11
Enhancer regulation in cancer: from epigenetics to m6A RNA modification	11
Physiologically based pharmacokinetic (PBPK) modeling of gliclazide for different genotypes of CYP2C9 and CYP2C19	11
Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis	11
Latest research progress on anticancer effect of baicalin and its aglycone baicalein	11
Effects of CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy subjects	11
Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice	10
Histone lactylation in gastrointestinal cancers: developing immunotherapeutic drugs targeting epigenetics	10
Site-selective addition of succinimide motif through nitro-assisted C–H functionalization of (hetero) arenes under rhodium catalysis	10
Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/FOXO3 signaling pathways	10
Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins	10
Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments	10
Exploring NNMT: from metabolic pathways to therapeutic targets	10
Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson’s disease treatment	10
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis	10
Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms	10
Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells	10
Comparative evaluation of bioactive phytochemicals in Spinacia oleracea cultivated under greenhouse and open field conditions	10
Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management	10
Antitumor activity of Polygonatum sibiricum polysaccharides	10
Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs	10
Physiologically based pharmacokinetic (PBPK) modeling of flurbiprofen in different CYP2C9 genotypes	9
Retraction Note: MiR-338-5p ameliorates pathological cardiac hypertrophy by targeting CAMKIIδ	9
Silybin inhibits succinate production and secretion in hepatocytes to reverse liver fibrosis	9
Prediction of human pharmacokinetic parameters incorporating SMILES information	9
Pharmacological targeting of HDAC/BET pathway enhances 5-FU efficacy in esophageal squamous cancer cells	9
Targeting dysregulated lipid metabolism in the tumor microenvironment	9
JAK2/STAT3-dependent regulation of MDM4/MDM2-p53 signaling in methotrexate-induced ferroptosis and nephrotoxicity	9
Neuroprotective effects of taurine in a rodent model of parkinson’s disease involve modulating astrocyte-mediated inflammation	9
Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway	9
Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress	8
C-phycocyanin reinforces autophagy to block pulmonary fibrogenesis by inhibiting lncIAPF biogenesis	8
Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression	8
Dual inhibitors of P-glycoprotein and breast cancer resistance protein for overcoming the blood–brain barrier: in silico discovery and preclinical evaluation	8
Associations between the gut microbiota and the metabolism rate of tacrolimus in kidney transplant recipients during the early posttransplant period	8
Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine	8
Inhibition of RBPJ transcription complex promotes IL-17 and IFN-γ secretion by CD4⁺ T cells in hepatocellular carcinoma	8