European Journal of Medicinal Chemistry

Article	Citations
Discovery of Sortase A covalent inhibitors with benzofuranene cyanide structures as potential antibacterial agents against Staphylococcus aureus	346
Design and synthesis of new potent 5-HT7 receptor ligands as a candidate for the treatment of central nervous system diseases	276
Thiophene-2-carboxamide derivatives of anthraquinone: A new potent antitumor chemotype	152
Overview of the development of HBV small molecule inhibitors	140
Developments of PROTACs technology in immune-related diseases	134
Editorial Board	120
Editorial Board	113
Graphical abstract TOC	113
Discovery of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis	111
Annual review of KRAS inhibitors in 2022	108
Photosensitizer associated with efflux pump inhibitors as a strategy for photodynamic therapy against bacterial resistance	104
2,6-diazaspiro[3.4]octan-7-one derivatives as potent sigma-1 receptor antagonists that enhanced the antinociceptive effect of morphine and rescued morphine tolerance	101
Novel α-mangostin derivatives as promising antiviral agents: Isolation, synthesis, and evaluation against chikungunya virus	100
Design, synthesis and biological evaluation of galantamine analogues for cognitive improvement in Alzheimer's disease	99
Identification of a selective pyruvate dehydrogenase kinase 1 (PDHK1) chemical probe by virtual screening	93
Developing dual-responsive quinolinium prodrugs of 8-hydroxyquinoline by harnessing the dual chelating sites	91
A novel pan-selective bromodomain inhibitor for epigenetic drug design	89
Identification of a short ACE2-derived stapled peptide targeting the SARS-CoV-2 spike protein	88
Glycoconjugates of adefovir and tenofovir as asialoglycoprotein-mediated Anti-HBV prodrugs with enhanced liver targeting	88
Antiviral drug discovery: Pyrimidine entry inhibitors for Zika and dengue viruses	85
Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket	82
Discovery of new and highly effective quadruple FFA1 and PPARα/γ/δ agonists as potential anti-fatty liver agents	82
Graphical abstract TOC	80
Engineering a biomimicking strategy for discovering nonivamide-based quorum-sensing inhibitors for controlling bacterial infection	75
Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers	75

trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease	75
A novel series of teriflunomide derivatives as orally active inhibitors of human dihydroorotate dehydrogenase for the treatment of colorectal carcinoma	74
Discovery of (2-(pyrrolidin-1-yl)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone as a novel potent tubulin depolymerizing and vascular disrupting agent	72
The polyamino-isoprenyl potentiator NV716 revives disused antibiotics against Gram-negative bacteria in broth, infected monocytes, or biofilms, by disturbing the barrier effect of their outer membrane	71
Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration	71
Estrogen receptor β-targeted hypoxia-responsive near-infrared fluorescence probes for prostate cancer study	70
Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities	70
Pleiotropic effects of a mitochondrion-targeted glutathione reductase inhibitor on restraining tumor cells	69
Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies	68
Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway	68
Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties	67
Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines	67
Design, synthesis and biological evaluation of new quinazolinone-benzopyran-indole hybrid compounds promoting osteogenesis through BMP2 upregulation	67
Quinoline heterocyclic containing plant and marine candidates against drug-resistant Mycobacterium tuberculosis: A systematic drug-ability investigation	67
Design, synthesis, and bioactivity evaluation of novel indole-selenide derivatives as P-glycoprotein inhibitors against multi-drug resistance in MCF-7/ADR cell	66
A step towards gadolinium-free bioresponsive MRI contrast agent	66
Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors	66
Discovery of potent small molecule inhibitors of histone lysine methyltransferase NSDs	66
Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy	66
Small molecule inhibitors targeting heat shock protein 90: An updated review	66
Novel acridine-based LSD1 inhibitors enhance immune response in gastric cancer	66
Small molecules with tetrahydroquinoline-containing Povarov scaffolds as inhibitors disrupting the Protein–RNA interaction of LIN28–let-7	64
Novel 5-aminopyrazoles endowed with anti-angiogenetic properties: Design, synthesis and biological evaluation	63
Targeting phosphatases: From molecule design to clinical trials	63
Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors	62
Probing benzenesulfonamide–thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase	62
Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010–2020)	62
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia	61
(1R,3S)-THCCA-Asn: To show the discovery of selective inhibitor of thrombin by successfully combining virtual screening and biological assay	61
Large-scale isolation and antitumor mechanism evaluation of compounds from the traditional Chinese medicine Cordyceps Militaris	61
Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7	61
Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors	57
Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice	57
Discovery of novel AdipoRon analogues as potent anti-inflammatory agents against nonalcoholic steatohepatitis	55
2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors	55
Design, synthesis, and biological evaluation of novel glutaminase 1 allosteric inhibitors with an alkane chain tail group	54
Editorial Board	54
Synthesis of urea and thiourea derivatives of C20-epi-aminosalinomycin and their activity against Trypanosoma brucei	53
Editorial Board	53
New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxid	53
Identification of inhibitors as drug candidates against Chagas disease	53
Pyrrole-thiazolidinone hybrids as a new structural class of broad-spectrum anti-infectives	52
Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis	52
Graphical abstract TOC	51
A branched small molecule-drug conjugate nanomedicine strategy for the targeted HCC chemotherapy	51
Graphical abstract TOC	51
Development of novel celastrol-ligustrazine hybrids as potent peroxiredoxin 1 inhibitors against lung cancer	50
Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist	50
Editorial Board	50
Graphical abstract TOC	49

Graphical abstract TOC	49
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer	49
Design, synthesis and biological evaluation of a novel N-aminoacyl derivative of amphotericin B methyl ester as an antifungal agent	49
Discovery of benzamide-based PI3K/HDAC dual inhibitors with marked pro-apoptosis activity in lymphoma cells	48
Tackling resistance in chronic myeloid leukemia: Novel cell death modulators with improved efficacy	48
Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury	48
Graphical abstract TOC continued	47
Design, synthesis, and structure-activity relationships of a novel class of quinazoline derivatives as coronavirus inhibitors	47
Discovery of 3H-pyrrolo[2,3-c]quinolines with activity against Mycobacterium tuberculosis by allosteric inhibition of the glutamate-5-kinase enzyme	47
C(21)-fluorinated thevinol scaffold for opioid ligands. 21,21,21-Trifluoro-6-O-nororvinols: Design, synthesis and analgesic activity	47
Graphical abstract contents continued	46
Editorial Board	46
Synthesis of 8-aminomorphans with high KOR affinity	45
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy	45
Identification of N, C-capped di- and tripeptides as selective immunoproteasome inhibitors	44
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)	44
Discovery and optimization of indirubin derivatives as novel ferroptosis inducers for the treatment of colon cancer	44
New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263	44
Editorial Board	44
contents continued	43
Development of potent isoflavone-based formyl peptide receptor 1 (FPR1) antagonists and their effects in gastric cancer cell models	43
Graphical abstract TOC	43
Pharmacological approaches to cystic fibrosis	43
Design, synthesis and antitubercular activity of novel N-(amino)piperazinyl benzothiazinones with improved safety	42
Contents Continued	42
Discovery of orally active sulfonylphenyl thieno[3,2-d]pyrimidine derivatives as GPR119 agonists	42
A novel ICG-labeled cyclic TMTP1 peptide dimer for sensitive tumor imaging and enhanced photothermal therapy in vivo	42
Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease	42
Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors	42
Discovery of small-molecule protein stabilizers toward exogenous alpha-l-iduronidase to reduce the accumulated heparan sulfate in mucopolysaccharidosis type I cells	41
Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation	41
Graphical abstract TOC	41
ProfKin: A comprehensive web server for structure-based kinase profiling	41
Current medicinal chemistry strategies in the discovery of novel HIV-1 ribonuclease H inhibitors	41
Computer-aided identification, synthesis, and biological evaluation of DNA polymerase η inhibitors for the treatment of cancer	41
Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents	41
Synthesis and biological evaluation of novel pyrazole amides as potent mitochondrial complex I inhibitors	40
The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance	40
Synthesis of melampomagnolide B derivatives as potential anti-Triple Negative Breast Cancer agents	40
Editorial Board	40
A pro-death autophagy-based nanoplatform for enhancing antitumour efficacy with improved immune responses	39
Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy	39
Graphical abstract TOC	39
Discovery of indirubin-3′-aminooxy-acetamide derivatives as potent and selective FLT3/D835Y mutant kinase inhibitors for acute myeloid leukemia	39
Editorial Board	39
Discovery of C-3 isoxazole substituted thiochromone S,S-dioxide derivatives as potent and selective inhibitors for monoamine oxidase B (MAO-B)	39
Editorial Board	39
Editorial	39
Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors	39
Graphical abstract TOC	39
Graphical abstract TOC	39
A novel scaffold long-acting selective estrogen receptor antagonist and degrader with superior preclinical profile against ER+ breast cancer	39
Contents continued	38
Graphical abstract TOC	38
Design, synthesis, and biological evaluation of 1-styrenyl isoquinoline derivatives for anti-hepatocellular carcinoma activity and effect on mitochondria	38
Synthesis of cinnamoyl tethered indoline derivatives with anti-inflammatory and antioxidant activities	38
A decade of USFDA-approved small molecules as anti-inflammatory agents: Recent trends and Commentaries on the “industrial” perspective	38
Design, synthesis, and biological evaluation of piperazine derivatives as pan-PPARs agonists for the treatment of liver fibrosis	38
Editorial Board	38
Graphical abstract TOC	38
Identification of 3-aryl-5-methyl-isoxazole-4-carboxamide derivatives and analogs as novel HIF-2α agonists through docking-based virtual screening and structural modification	38
Novel strategies based on natural products and synthetic derivatives to overcome resistance in Mycobacterium tuberculosis	37
Identification of a ferritinophagy inducer via sinomenine modification for the treatment of colorectal cancer	37
Research progress of DDR1 inhibitors in the treatment of multiple human diseases	37
Recent research progress based on ferroptosis-related signaling pathways and the tumor microenvironment on it effects	37
Editorial Board	37
Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain	37
Graphical abstract TOC	37
Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H)	37
Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability	37
Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity	37
Acyloxymethyl and alkoxycarbonyloxymethyl prodrugs of a fosmidomycin surrogate as antimalarial and antibacterial agents	37
Targeting the phosphoserine phosphatase MtSerB2 for tuberculosis drug discovery, an hybrid knowledge based /fragment based approach	36
6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis	36
Novel C-3-(N-alkyl-aryl)-aminomethyl rifamycin SV derivatives exhibit activity against rifampicin-resistant Mycobacterium tuberculosis RpoBS522L strain and display a different binding mode at the RNAP	36
Discovery and evaluation of aza-fused tricyclic derivatives for detection of Tau pathology in Alzheimer's disease	36
Fused-ring α-pyrones from intramolecular C–H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation	36
Graphical abstract TOC	36
The evolution paths of some reprehensive scaffolds of RORγt modulators, a perspective from medicinal chemistry	36
Editorial Board	36

Design, synthesis and biological evaluation of multitarget hybrid molecules containing NHC-Au(I) complexes and carbazole moieties	35
Graphical abstract TOC	35
Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization	35
Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit	35
A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo	35
Recent discovery of natural substances with cathepsin L-inhibitory activity for cancer metastasis suppression	34
Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition	34
Designing and development of phthalimides as potent anti-tubulin hybrid molecules against malaria	34
Synthesis and preclinical evaluation of a heterodimeric radioligand targeting fibroblast activation protein and integrin-αvβ3	34
Synthetic routes and clinical application of new drugs approved by EMA during 2023	34
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity	34
Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity	34
Non-nucleoside structured compounds with antiviral activity—past 10 years (2010–2020)	34
Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach	34
Design, synthesis, and biological evaluation of novel 4,4′-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer	34
Design, synthesis, and evaluation of new anti-inflammatory natural products amide derivatives endowed with anti-blood cancer activity towards development of potential multifunctional agents against he	34
Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action	33
Metabolic and conformational stabilization of a VEGF-mimetic beta-hairpin peptide by click-chemistry	33
Design, synthesis, and anti-respiratory syncytial virus potential of novel 3-(1,2,3-triazol-1-yl)furoxazine-fused benzimidazole derivatives	33
Optimization and SAR research at the piperazine and phenyl rings of JNJ4796 as new anti-influenza A virus agents, part 1	33
Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors	33
A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells	33
Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase	33
Design and evaluation of novel piperidine HIV-1 protease inhibitors with potency against DRV-resistant variants	33
Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor	33
Novel benzothiazole‒urea hybrids: Design, synthesis and biological activity as potent anti-bacterial agents against MRSA	33
Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable “click” oxime bond tethers and preclinical evaluation against prostate cancer	33
Discovery of a novel homoisoflavonoid derivative 5g for anti-osteoclastic bone loss via targeting FGFR1	33
Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses	32
Similarities and differences between embryonic implantation and CTC invasion: Exploring the roles of abortifacients in cancer metastasis chemoprevention	32
Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma	32
Medicinal chemistry strategies targeting NLRP3 inflammasome pathway: A recent update from 2019 to mid-2023	32
Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy	32
Gemfibrozil derivatives as activators of soluble guanylyl cyclase – A structure-activity study	32
Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells	32
Advances on structure, bioactivity, and biosynthesis of amino acid-containing trans-AT polyketides	32
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity	32
New and promising type of leukotriene B4 (LTB4) antagonists based on the 1,4-benzodioxine structure	32
Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors	31
Discovery of novel ocotillol derivatives modulating glucocorticoid receptor/NF-κB signaling for the treatment of sepsis	31
Analogues of natural products yaequinolones as potential inflammatory inhibitors: Design, synthesis and biological evaluation	31
Platinum(IV) complexes as inhibitors of CD47-SIRPα axis for chemoimmunotherapy of cancer	31
Editorial Board	31
Synthesis and anticancer activity of novel histone deacetylase inhibitors that inhibit autophagy and induce apoptosis	31
Designed symmetrical β-hairpin peptides for treating multidrug-resistant salmonella typhimurium infections	31
Design, synthesis and evaluation of 3-amide-5-aryl benzoic acid derivatives as novel P2Y14R antagonists with potential high efficiency against acute gouty arthritis	31
Novel selective agents for the degradation of AR/AR-V7 to treat advanced prostate cancer	31
Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy	31
Recent advance of small-molecule drugs for clinical treatment of osteoporosis: A review	31
Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with α-ketoamide warheads	30
Histone deacetylases (HDACs) as the promising immunotherapeutic targets for hematologic cancer treatment	30
Amlexanox-modified platinum(IV) complex triggers apoptotic and autophagic bimodal death of cancer cells	30
Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease	30
Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity	30
Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities	30
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route	30
Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition	30
Evaluation of central-metal effect on anticancer activity and mechanism of action of isostructural Cu(II) and Ni(II) complexes containing pyridine-2,6-dicarboxylate	30
Identification of novel benzothiopyranones with ester and amide motifs derived from active metabolite as promising leads against Mycobacterium tuberculosis	30
Synthesis and bioactivities of new N-terminal dipeptide mimetics with aromatic amide moiety: Broad-spectrum antibacterial activity and high antineoplastic activity	30
Antibacterial activity evaluation of pleuromutilin derivatives with 4(3H)-quinazolinone scaffold against methicillin-resistant Staphylococcus aureus	30
Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide molecular hybrids as potential antimalarial agents	30
Si113-prodrugs selectively activated by plasmin against hepatocellular and ovarian carcinoma	30
Design and synthesis of aptamer-cyclometalated iridium(III) complex conjugate targeting cancer cells	30
Effects of substituent pattern on the intracellular target of antiproliferative benzo[b]thiophenyl chromone derivatives	29
Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation	29
New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial leads	29
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma	29
Recent advances in targeting histone H3 lysine 36 methyltransferases for cancer therapy	29
Design, synthesis, and biological evalution of bifunctional inhibitors against Hsp90-HDAC6 interplay	29
Graphical abstract TOC	29
Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies	29
Contents continued	29
New nimesulide derivatives with amide/sulfonamide moieties: Selective COX-2 inhibition and antitumor effects	29
Small molecules that regulate the N6-methyladenosine RNA modification as potential anti-cancer agents	29
N-substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: Synthesis, biological activity and computational analysis	29
A glycyrrhetinic acid-iridium(III) conjugate as a theranostic NIR probe for hepatocellular carcinoma with mitochondrial-targeting ability	29
Synthesis and clinical application of representative small-molecule dipeptidyl Peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes mellitus (T2DM)	28
Mono-quinoxaline-induced DNA structural alteration leads to ZBP1/RIP3/MLKL-driven necroptosis in cancer cells	28
Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present)	28
Design, synthesis, and repurposing of O-aminoalkyl-sulfuretin analogs towards discovery of potential lead compounds as antileishmanial agents	28
Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs	28
Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors	28
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation	28
Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease	28
Design, synthesis and activity evaluation of isopropylsulfonyl-substituted 2,4- diarylaminopyrimidine derivatives as FAK inhibitors for the potential treatment of pancreatic cancer	28
New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel	28
Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer’s disease	28
Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies	28
Discovery of small-molecule compounds and natural products against Parkinson's disease: Pathological mechanism and structural modification	27
An insight into the pharmacology of cysteine/methionine containing peptide drugs	27
Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors	27
Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents	27
Discovery of N-substituted sulfamoylbenzamide derivatives as novel inhibitors of STAT3 signaling pathway based on Niclosamide	27
Synthesis and evaluation of adenosine derivatives as A1, A2A, A2B and A3 adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A3 agonists	27