OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
	229
	211
Key characters of glycodrugs	195
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	171
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	147
Galectin‐8 inhibition and functions in immune response and tumor biology	145
In Memoriam: Professor Minyong Li (1976–2025)	116
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	115
Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns	110
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	95
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	91
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	87
Accelerating Small Molecule Ferroptosis Regulator Development With Advances in Biological Functions	84
New drug approvals for 2022: Synthesis and clinical applications	83
Front Cover Image, Volume 45, Issue 1	82
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	81
Issue Information	80
	80
Current and emerging approaches to noncompetitive AR inhibition	77
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	74
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	65
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	63
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	63
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	47
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	46

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	43
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	42
Mitochondrial quality control proteases and their modulation for cancer therapy	42
Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery	41
Current nanocomposite advances for biomedical and environmental application diversity	39
Enhancing healthy aging with small molecules: A mitochondrial perspective	39
Emerging roles of nerve‐bone axis in modulating skeletal system	39
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	39
Issue Information	37
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	37
Human Cyclophilins—An Emerging Class of Drug Targets	36
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	36
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy	36
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	33
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	33
Inside Front Cover Image, Volume 44, Issue 5	33
LSD1 in drug discovery: From biological function to clinical application	33
Advances in reversible covalent kinase inhibitors	33
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	33
An overview of the progress made in research into the Mpox virus	33
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	32
Targeting epigenetic modifications in Parkinson's disease therapy	32
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	32
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	32
	31
ER stress and inflammation crosstalk in obesity	31
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases	31
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	31
	30
Issue Information	30
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches	29
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications	29
	29
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	28
Kinin B ₁ and B ₂ Receptors: Role in Tumor Progression and Pain Associated With Tumor and Anticanc	28
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	28
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	27
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	27
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	26
Chemistry and biological activity of resin glycosides from Convolvulaceae species	25
Computational benchmarking of putative KIFC1 inhibitors	25
Harnessing the Power of Natural Products for Targeted Protein Degradation	25
	24
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	24
	24
Issue Information	24
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	23
Front Cover Image, Volume 45, Issue 4	23
Medicinal Chemistry Strategies for the Development of CD73 Inhibitors in Cancer Immunotherapy	22
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	22

Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	22
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	22
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	22
Tirzepatide in Metabolic Diseases: Clinical Efficacy and Safety Beyond Diabetes and Obesity	22