Medicinal Research Reviews

(The TQCC of Medicinal Research Reviews is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
Machine intelligence in peptide therapeutics: A next‐generation tool for rapid disease screening165
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications137
The role of hypoxia‐inducible factor 1 in tumor immune evasion129
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases118
Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)118
Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention107
Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules104
Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?104
Molecular targeting therapies for neuroblastoma: Progress and challenges95
A gold mine for drug discovery: Strategies to develop cyclic peptides into therapies88
Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation88
Small molecules regulating reactive oxygen species homeostasis for cancer therapy85
Biologically active isoquinoline alkaloids covering 2014–201884
Understanding the tumor microenvironment for effective immunotherapy84
Tripterygium wilfordii: An inspiring resource for rheumatoid arthritis treatment79
Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions75
Mechanisms of melanocyte death in vitiligo75
Agonists and inhibitors of the STING pathway: Potential agents for immunotherapy74
Therapeutic potential of phenylethanoid glycosides: A systematic review69
Bilirubin as a signaling molecule68
Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure‐activity relationship67
Design and synthesis of glycomimetics: Recent advances67
From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology66
Flavonoids as antiobesity agents: A review63
Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases62
Inducible nitric oxide synthase inhibitors: A comprehensive update61
Emerging carrier‐free nanosystems based on molecular self‐assembly of pure drugs for cancer therapy61
What coronavirus 3C‐like protease tells us: From structure, substrate selectivity, to inhibitor design60
Bioactive polymeric scaffolds for osteogenic repair and bone regenerative medicine57
Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: A therapeutic target to control intestinal inflammation57
COVID‐19 drug repurposing: A review of computational screening methods, clinical trials, and protein interaction assays56
Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali Radix)56
A review in radiomics: Making personalized medicine a reality via routine imaging56
Medicinal chemistry strategies toward host targeting antiviral agents55
The immunosuppressive activity of artemisinin‐type drugs towards inflammatory and autoimmune diseases54
Autophagy and cardiac diseases: Therapeutic potential of natural products54
Emerging roles of SIRT6 in human diseases and its modulators53
The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy52
Emerging use of senolytics and senomorphics against aging and chronic diseases51
Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing50
The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future47
Skp2 in the ubiquitin‐proteasome system: A comprehensive review46
Targeting MDM2 for novel molecular therapy: Beyond oncology46
Development of anti‐influenza agents from natural products44
Direct targeting of β‐catenin in the Wnt signaling pathway: Current progress and perspectives43
Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review43
Hybrid molecules with potential in vitro antiplasmodial and in vivo antimalarial activity against drug‐resistant Plasmodium falciparum43
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections43
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas42
Reinvigorating exhausted CD8+ cytotoxic T lymphocytes in the tumor microenvironment and current strategies in cancer immunotherapy41
Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer41
Mitochondrial dysfunction in cardiovascular disease: Current status of translational research/clinical and therapeutic implications41
Repurposing approved drugs on the pathway to novel therapies40
Carbon monoxide: An emerging therapy for acute kidney injury39
Biologically active indolizidine alkaloids38
The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases38
Principles and current strategies targeting metallo‐β‐lactamase mediated antibacterial resistance37
A novel strategy for the diagnosis, prognosis, treatment, and chemoresistance of hepatocellular carcinoma: DNA methylation35
Hepcidin and its therapeutic potential in neurodegenerative disorders34
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition34
Therapeutic strategies for targeting telomerase in cancer34
Pattern recognition receptor‐mediated inflammation in diabetic vascular complications34
The aryl hydrocarbon receptor (AhR) as a breast cancer drug target34
Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism33
Artemisinin‐derived antimalarial endoperoxides from bench‐side to bed‐side: Chronological advancements and future challenges33
Protein corona formed in the gastrointestinal tract and its impacts on oral delivery of nanoparticles33
Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol33
Targeting telomerase for its advent in cancer therapeutics32
Cistanches Herba, from an endangered species to a big brand of Chinese medicine32
Harnessing hyperuricemia to atherosclerosis and understanding its mechanistic dependence32
Expert insights: The potential role of the gut microbiome‐bile acid‐brain axis in the development and progression of Alzheimer's disease and hepatic encephalopathy32
Cerebrolysin in the therapy of mild cognitive impairment and dementia due to Alzheimer's disease: 30 years of clinical use31
Anti‐VEGF DNA‐based aptamers in cancer therapeutics and diagnostics31
Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease31
Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets31
The mitochondrial permeability transition pore in cell death: A promising drug binding bioarchitecture30
Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities30
Recent updates on the resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors and resistance reversion strategies in lung cancer29
Targeting B7‐1 in immunotherapy29
The role and therapeutic potential of Hsp90, Hsp70, and smaller heat shock proteins in peripheral and central neuropathies29
Cardiac efficacy and toxicity of aconitine: A new frontier for the ancient poison28
Strategies for designing proteolysis targeting chimaeras (PROTACs)28
SARS‐CoV‐2‐mediated immune system activation and potential application in immunotherapy28
New‐generation, non‐SSRI antidepressants: Drug‐drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others28
Making smart drugs smarter: The importance of linker chemistry in targeted drug delivery28
The role of carbon monoxide, heme oxygenase 1, and the Nrf2 transcription factor in the modulation of chronic pain and their interactions with opioids and cannabinoids27
The Yin and Yang of traditional Chinese and Western medicine27
Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era27
Trends in targeted delivery of nanomaterials in colon cancer diagnosis and treatment27
Drug design targeting active posttranslational modification protein isoforms26
Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants25
NLRP3 inflammasome in cardiovascular diseases: Pathophysiological and pharmacological implications25
Recent advances with 5‐HT3 modulators for neuropsychiatric and gastrointestinal disorders25