OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
	257
	236
Key characters of glycodrugs	208
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	186
Accelerating Small Molecule Ferroptosis Regulator Development With Advances in Biological Functions	163
In Memoriam: Professor Minyong Li (1976–2025)	135
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	125
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria	123
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	104
Galectin‐8 inhibition and functions in immune response and tumor biology	103
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	103
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	99
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	96
New drug approvals for 2022: Synthesis and clinical applications	89
Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns	89
Front Cover Image, Volume 45, Issue 1	82
	78
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	73
Issue Information	71
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	65
Current and emerging approaches to noncompetitive AR inhibition	61
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	50
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	49
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	48
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	48

Enhancing healthy aging with small molecules: A mitochondrial perspective	47
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	47
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	47
A Possibility of Synthetic Lethality: Wee1 Kinase as a Promising Treating Target for Cancer	41
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	40
Current nanocomposite advances for biomedical and environmental application diversity	40
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	40
Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression	40
Mitochondrial quality control proteases and their modulation for cancer therapy	39
Issue Information	39
Emerging roles of nerve‐bone axis in modulating skeletal system	39
Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery	39
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	38
Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000–2025)	37
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy	37
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	36
Human Cyclophilins—An Emerging Class of Drug Targets	36
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	36
Inside Front Cover Image, Volume 44, Issue 5	36
Targeting epigenetic modifications in Parkinson's disease therapy	36
LSD1 in drug discovery: From biological function to clinical application	34
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	34
An overview of the progress made in research into the Mpox virus	33
Advances in reversible covalent kinase inhibitors	32
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	31
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases	30
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	30
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	30
Issue Information	29
ER stress and inflammation crosstalk in obesity	29
	29
Emerging Trends in Artificial Intelligence‐Driven Drug Discovery: Balancing Chemical Design and Pharmacological Properties for Cancer Therapy	29
	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	29
	28
Quantification of ¹⁰ B and ¹¹ B in Biological Samples in Translational Science and Clinical Applic	28
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches	28
Kinin B ₁ and B ₂ Receptors: Role in Tumor Progression and Pain Associated With Tumor and Anticanc	28
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications	28
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	27
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	26
Decoding the Toxicity of Synthetic Cannabinoids: From Receptor Activation to Multiorgan Dysfunction	26
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	26
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	26
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	25
Harnessing the Power of Natural Products for Targeted Protein Degradation	25
Computational benchmarking of putative KIFC1 inhibitors	25
Issue Information	25
	24
Front Cover Image, Volume 45, Issue 4	24

	24
Medicinal Chemistry Strategies for the Development of CD73 Inhibitors in Cancer Immunotherapy	24
Targeting ClpP Protease: Emerging Therapeutic Strategies and Small‐Molecule Modulators in Drug Discovery	23
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	23
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	22
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	22
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	22
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	22
Tirzepatide in Metabolic Diseases: Clinical Efficacy and Safety Beyond Diabetes and Obesity	22
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	22