OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
	197
	185
	166
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	162
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	132
New drug approvals for 2022: Synthesis and clinical applications	125
Key characters of glycodrugs	113
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	108
Galectin‐8 inhibition and functions in immune response and tumor biology	105
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	86
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	86
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	85
Front Cover Image, Volume 45, Issue 1	78
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	73
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	73
Current and emerging approaches to noncompetitive AR inhibition	72
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	72
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	71
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	65
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	63
Emerging roles of nerve‐bone axis in modulating skeletal system	63
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	58
Enhancing healthy aging with small molecules: A mitochondrial perspective	57
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	55
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	55

Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	45
Mitochondrial quality control proteases and their modulation for cancer therapy	43
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	42
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	42
Current nanocomposite advances for biomedical and environmental application diversity	39
Issue Information	39
Issue Information	38
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy	36
Human Cyclophilins—An Emerging Class of Drug Targets	36
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	35
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	33
An overview of the progress made in research into the Mpox virus	32
Inside Front Cover Image, Volume 44, Issue 5	32
Advances in reversible covalent kinase inhibitors	31
Targeting epigenetic modifications in Parkinson's disease therapy	30
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	30
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases	29
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	29
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	29
ER stress and inflammation crosstalk in obesity	29
LSD1 in drug discovery: From biological function to clinical application	29
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	28
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	28
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	27
Issue Information	27
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	27
	27
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	27
Kinin B ₁ and B ₂ Receptors: Role in Tumor Progression and Pain Associated With Tumor and Anticanc	26
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches	26
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	26
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications	26
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	26
Harnessing the Power of Natural Products for Targeted Protein Degradation	25
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	25
Cardiovascular therapeutics: A new potential for anxiety treatment?	24
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	24
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	24
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	23
Computational benchmarking of putative KIFC1 inhibitors	23
	22
Issue Information	22
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	22
Chemistry and biological activity of resin glycosides from Convolvulaceae species	22
	22
Front Cover Image, Volume 45, Issue 4	21
Genetically modified cancer vaccines: Current status and future prospects	21
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	21
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	20

Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	20
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	20
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	20