OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
	170
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	147
New drug approvals for 2022: Synthesis and clinical applications	142
	136
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	130
Key characters of glycodrugs	112
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	98
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	96
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	91
Galectin‐8 inhibition and functions in immune response and tumor biology	88
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	87
Front Cover Image, Volume 45, Issue 1	82
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	77
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	68
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	68
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	67
Current and emerging approaches to noncompetitive AR inhibition	64
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	64
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	63
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	63
Association predictions of genomics, proteinomics, transcriptomics, microbiome, metabolomics, pathomics, radiomics, drug, symptoms, environment factor, and disease networks: A comprehensive approach	59
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	56
Mitochondrial quality control proteases and their modulation for cancer therapy	53
Enhancing healthy aging with small molecules: A mitochondrial perspective	52
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	51

α‐Synuclein in Parkinson's Disease: From Bench to Bedside	49
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	47
Emerging roles of nerve‐bone axis in modulating skeletal system	47
Current nanocomposite advances for biomedical and environmental application diversity	46
Issue Information	43
Issue Information	42
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	39
The role of Wnt signaling in skin fibrosis	38
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	36
Targeting epigenetic modifications in Parkinson's disease therapy	35
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	34
Inside Front Cover Image, Volume 44, Issue 5	34
LSD1 in drug discovery: From biological function to clinical application	33
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	33
An overview of the progress made in research into the Mpox virus	32
	32
Advances in reversible covalent kinase inhibitors	32
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	31
ER stress and inflammation crosstalk in obesity	31
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	30
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	27
	26
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	26
	26
	26
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	25
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	25
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	25
Cardiovascular therapeutics: A new potential for anxiety treatment?	25
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	25
The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	25
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	25
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	24
Computational benchmarking of putative KIFC1 inhibitors	24
	23
Chemistry and biological activity of resin glycosides from Convolvulaceae species	23
Harnessing the Power of Natural Products for Targeted Protein Degradation	23
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	22
Issue Information	22
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	21
Front Cover Image, Volume 45, Issue 4	21
	21
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	21
	20
Genetically modified cancer vaccines: Current status and future prospects	20
Issue Information	20
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	20
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	20
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	20

Advances in machine intelligence‐driven virtual screening approaches for big‐data	19
	19
	19
Recent Developments in the Optical Control of Adrenergic Signaling	19