OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
	190
	172
	163
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	159
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	151
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	129
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	119
Galectin‐8 inhibition and functions in immune response and tumor biology	105
New drug approvals for 2022: Synthesis and clinical applications	105
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	103
Key characters of glycodrugs	86
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	83
Front Cover Image, Volume 45, Issue 1	78
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	76
Current and emerging approaches to noncompetitive AR inhibition	72
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	72
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	71
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	70
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	65
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	64
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	61
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	61
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	60
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	58
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	56

Enhancing healthy aging with small molecules: A mitochondrial perspective	53
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	53
Mitochondrial quality control proteases and their modulation for cancer therapy	51
Emerging roles of nerve‐bone axis in modulating skeletal system	42
Issue Information	39
Current nanocomposite advances for biomedical and environmental application diversity	39
Issue Information	38
Human Cyclophilins—An Emerging Class of Drug Targets	37
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	37
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy	37
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	36
Inside Front Cover Image, Volume 44, Issue 5	34
Advances in reversible covalent kinase inhibitors	34
Targeting epigenetic modifications in Parkinson's disease therapy	32
An overview of the progress made in research into the Mpox virus	31
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	29
LSD1 in drug discovery: From biological function to clinical application	29
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	29
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	29
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases	28
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	28
ER stress and inflammation crosstalk in obesity	28
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	28
	27
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications	27
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	27
Issue Information	27
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	26
	26
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches	26
	26
Cardiovascular therapeutics: A new potential for anxiety treatment?	25
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	25
Computational benchmarking of putative KIFC1 inhibitors	25
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	25
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	25
Harnessing the Power of Natural Products for Targeted Protein Degradation	25
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	25
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	24
Chemistry and biological activity of resin glycosides from Convolvulaceae species	24
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	24
Issue Information	23
	22
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	22
	22
Genetically modified cancer vaccines: Current status and future prospects	21
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	21
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	20
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	20
	20

Front Cover Image, Volume 45, Issue 4	20
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	20
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	20
Issue Information	20