OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
	437
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	184
New drug approvals for 2022: Synthesis and clinical applications	157
	128
Key characters of glycodrugs	123
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	123
Galectin‐8 inhibition and functions in immune response and tumor biology	114
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	111
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	93
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	92
Issue Information	86
Current and emerging approaches to noncompetitive AR inhibition	82
Front Cover Image, Volume 45, Issue 1	79
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	78
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	72
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	69
Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review	64
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	59
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	59
Mitochondrial quality control proteases and their modulation for cancer therapy	58
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	58
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	55
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	54
Association predictions of genomics, proteinomics, transcriptomics, microbiome, metabolomics, pathomics, radiomics, drug, symptoms, environment factor, and disease networks: A comprehensive approach	54
Enhancing healthy aging with small molecules: A mitochondrial perspective	54

Current nanocomposite advances for biomedical and environmental application diversity	53
Inside Front Cover Image, Volume 41, Issue 4	53
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	47
Emerging roles of nerve‐bone axis in modulating skeletal system	46
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	46
Issue Information	44
Issue Information	41
The role of Wnt signaling in skin fibrosis	41
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	41
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	37
Inside Front Cover Image, Volume 44, Issue 5	36
An overview of the progress made in research into the Mpox virus	36
Targeting epigenetic modifications in Parkinson's disease therapy	35
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	33
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	33
	32
Advances in reversible covalent kinase inhibitors	32
LSD1 in drug discovery: From biological function to clinical application	32
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	31
Recent pharmacological advances in the repurposing of artemisinin drugs	31
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	31
Artemisinin‐derived dimers from a chemical perspective	30
ER stress and inflammation crosstalk in obesity	30
The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	29
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	29
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	28
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	26
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	25
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	25
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	24
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	23
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	23
Corrigendum: Molecular targeting therapies for neuroblastoma: Progress and challenges	23
Computational benchmarking of putative KIFC1 inhibitors	23
Chemistry and biological activity of resin glycosides from Convolvulaceae species	22
	21
Cardiovascular therapeutics: A new potential for anxiety treatment?	21
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	21
Harnessing the Power of Natural Products for Targeted Protein Degradation	21
Issue Information	21
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	21
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	20
	20
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	20
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	20
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	19
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	19

Issue Information	19
Genetically modified cancer vaccines: Current status and future prospects	19
	18
	18
	18
	18