OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
	203
	193
	174
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	169
Key characters of glycodrugs	144
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	128
New drug approvals for 2022: Synthesis and clinical applications	119
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	116
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	107
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	89
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	88
Galectin‐8 inhibition and functions in immune response and tumor biology	88
Front Cover Image, Volume 45, Issue 1	81
	77
Current and emerging approaches to noncompetitive AR inhibition	76
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	75
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	73
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	71
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	67
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	66
Enhancing healthy aging with small molecules: A mitochondrial perspective	65
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	65
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	64
Current nanocomposite advances for biomedical and environmental application diversity	58
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	52

Mitochondrial quality control proteases and their modulation for cancer therapy	47
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	46
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	42
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	42
Emerging roles of nerve‐bone axis in modulating skeletal system	40
Issue Information	39
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy	37
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	36
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	35
Human Cyclophilins—An Emerging Class of Drug Targets	35
Inside Front Cover Image, Volume 44, Issue 5	34
Advances in reversible covalent kinase inhibitors	34
An overview of the progress made in research into the Mpox virus	34
Targeting epigenetic modifications in Parkinson's disease therapy	33
LSD1 in drug discovery: From biological function to clinical application	33
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	31
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	31
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	30
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	29
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	28
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	28
Issue Information	28
ER stress and inflammation crosstalk in obesity	28
	28
Kinin B ₁ and B ₂ Receptors: Role in Tumor Progression and Pain Associated With Tumor and Anticanc	27
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	27
	27
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches	27
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	27
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications	27
	27
Cardiovascular therapeutics: A new potential for anxiety treatment?	26
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	26
Computational benchmarking of putative KIFC1 inhibitors	26
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	26
Harnessing the Power of Natural Products for Targeted Protein Degradation	25
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	25
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	24
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	24
	23
Issue Information	23
Chemistry and biological activity of resin glycosides from Convolvulaceae species	23
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	22
	22
Front Cover Image, Volume 45, Issue 4	22
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	22
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	22
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	21
Genetically modified cancer vaccines: Current status and future prospects	21

Medicinal Chemistry Strategies for the Development of CD73 Inhibitors in Cancer Immunotherapy	21
Issue Information	20
Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy	20
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	20
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	20
	20