Medicinal Research Reviews

Article	Citations
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Key characters of glycodrugs	208
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	186
Accelerating Small Molecule Ferroptosis Regulator Development With Advances in Biological Functions	163
In Memoriam: Professor Minyong Li (1976–2025)	135
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	125
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria	123
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	104
Galectin‐8 inhibition and functions in immune response and tumor biology	103
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	103
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	99
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	96
Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns	89
New drug approvals for 2022: Synthesis and clinical applications	89
Front Cover Image, Volume 45, Issue 1	82
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Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	73
Issue Information	71
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	65
Current and emerging approaches to noncompetitive AR inhibition	61
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	50
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	49
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	48
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	48

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	47
Enhancing healthy aging with small molecules: A mitochondrial perspective	47
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	47
A Possibility of Synthetic Lethality: Wee1 Kinase as a Promising Treating Target for Cancer	41
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	40
Current nanocomposite advances for biomedical and environmental application diversity	40
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	40
Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression	40
Mitochondrial quality control proteases and their modulation for cancer therapy	39
Issue Information	39
Emerging roles of nerve‐bone axis in modulating skeletal system	39
Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery	39
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	38
Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000–2025)	37
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy	37
Inside Front Cover Image, Volume 44, Issue 5	36
Targeting epigenetic modifications in Parkinson's disease therapy	36
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	36
Human Cyclophilins—An Emerging Class of Drug Targets	36
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	36
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	34
LSD1 in drug discovery: From biological function to clinical application	34
An overview of the progress made in research into the Mpox virus	33
Advances in reversible covalent kinase inhibitors	32
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	31
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	30
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases	30
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	30
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Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	29
Issue Information	29
ER stress and inflammation crosstalk in obesity	29
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Emerging Trends in Artificial Intelligence‐Driven Drug Discovery: Balancing Chemical Design and Pharmacological Properties for Cancer Therapy	29
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Quantification of 10 B and 11 B in Biological Samples in Translational Science and Clinical Applic	28
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches	28
Kinin B 1 and B 2 Receptors: Role in Tumor Progression and Pain Associated With Tumor and Anticanc	28
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications	28
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	27
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	26
Decoding the Toxicity of Synthetic Cannabinoids: From Receptor Activation to Multiorgan Dysfunction	26
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	26
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	26
Computational benchmarking of putative KIFC1 inhibitors	25
Issue Information	25
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	25
Harnessing the Power of Natural Products for Targeted Protein Degradation	25
Medicinal Chemistry Strategies for the Development of CD73 Inhibitors in Cancer Immunotherapy	24
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Front Cover Image, Volume 45, Issue 4	24
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H+‐slip correlated to rotor free‐wheeling as cause of F1FO‐ATPase dysfunction in primary mitochondrial disorders	23
Targeting ClpP Protease: Emerging Therapeutic Strategies and Small‐Molecule Modulators in Drug Discovery	23
Tirzepatide in Metabolic Diseases: Clinical Efficacy and Safety Beyond Diabetes and Obesity	22
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	22
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	22
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	22
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	22
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	22
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Advances in SIRT2‐Targeted Therapeutics: Structural Insights, Chemical Strategies, and Degrader Technologies	21
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Comprehensive Insights Into Sulfanilamido‐Based Medicinal Design and Research	21
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Advances in machine intelligence‐driven virtual screening approaches for big‐data	20
Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy	20
Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms	20
Advances in Traditional Chinese Medicine for Diabetic Glaucoma: A Systematic Review From Holistic Pathogenesis to Multi‐Target Interventions	20
Recent Developments in the Optical Control of Adrenergic Signaling	20
Cuproptosis: Mechanism, role, and advances in urological malignancies	19
AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery	19
Synthesis and Clinical Application of Small‐Molecule Drugs Approved by FDA in 2025	19
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy	19
Poly (adenosine diphosphate‐ribose) polymerase inhibitors in the treatment of triple‐negative breast cancer with homologous repair deficiency	18
Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?	18
Issue Information	17
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Mucin O‐Glycosylation and Mucolytic Therapies in Pseudomyxoma Peritonei: Literature Review	17
Covalent Bifunctional Molecules (CBMs): Achievements and Challenges	17
Issue Information	17
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors	16
Near‐Infrared Fluorescent Probe for the Early Diagnosis of Alzheimer's Disease	16
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	16
Unleashing the Power of Covalent Drugs for Protein Degradation	16
Insights From Spatiality: Accelerating Pharmaceutical Research Using Mass Spectrometry Imaging	15
Late I Na as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation	15
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Drugging ERK1/2 in Cancer: A Glimpse of Small‐Molecule Inhibitors	15
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	15
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	15
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	15
Recent Advances of Non‐Nucleoside Polymerase Inhibitors With Broad‐Spectrum Antiviral Activities	15
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	14
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport	14
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	14
A Comprehensive Insight of Mechanisms of Drugs Targeting Ion Channels: Exemplified by Marine Natural Products and Their Analogues	14
Issue Information	13
The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	13
Front Cover Image, Volume 44, Issue 5	13
Chemo‐proteomics in antimalarial target identification and engagement	13
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	13
Issue Information	12
Issue Information	12
Recent Progress in Azobenzene‐Based In Vivo Photopharmacology	12
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?	12
Issue Information	12
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective	12
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Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	12
Issue Information	12
The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex	11
Pyroptosis and the fight against lung cancer	11
The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors	11
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases	11
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases	11
Issue Information	11
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines	11
Issue Information	10
The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications	10
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer	10
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin	9
Issue Information	9
Parkin exerts the tumor‐suppressive effect through targeting mitochondria	9
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras	9
Therapeutic Potential of Vascular Adhesion Protein‐1 (VAP‐1)/Semicarbazide‐Sensitive Amine Oxidase (SSAO) Inhibitors: Current Medicinal Chemistry and Emerging Opportunities	9
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance	9
Immunosuppressive Tumor Microenvironment and Therapeutic Landscape of Diffuse Intrinsic Pontine Glioma	9
Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy	8

Advances in Small Molecule Research Targeting Monoacylglycerol Lipase in Drug Discovery	8
Molecular Pharmacology of T‐Type Calcium Channels and Their Roles in Neurological Disorders	8
Beyond dopamine: Novel strategies for schizophrenia treatment	8
Advanced models for respiratory disease and drug studies	8
How Artificial Intelligence Assists in Overcoming Drug Resistance?	8
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates	7
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders	7
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer	7
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Front Cover Image, Volume 43, Issue 6	7