Medicinal Research Reviews

Article	Citations
Front Cover Image, Volume 41, Issue 4	358
Estrogen deficiency‐mediated osteoimmunity in postmenopausal osteoporosis	136
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	121
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Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach	91
Counter‐intuitive discovery in the formulation of poorly water‐soluble drugs: Amorphous small‐molecule gels	91
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	81
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Autosomic dominant polycystic kidney disease and metformin: Old knowledge and new insights on retarding progression of chronic kidney disease	76
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β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo	57
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Front Cover Image, Volume 43, Issue 4	53
Front Cover Image, Volume 44, Issue 4	52
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The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	47
Front Cover Image, Volume 41, Issue 6	46
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Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	43
Galectin‐8 inhibition and functions in immune response and tumor biology	42
Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness	40

Emerging potentials of Fe‐based nanomaterials for chiral sensing and imaging	39
The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases	38
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	38
Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery	37
Natural products as Zika antivirals	36
Key characters of glycodrugs	32
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	31
Microglia‐derived galectin‐3 in neuroinflammation; a bittersweet ligand?	31
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	30
Molecular mechanism(s) of regulations of cancer stem cell in brain cancer propagation	30
Peroral targeting of drug micro or nanocarriers to sites beyond the gastrointestinal tract	30
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	29
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The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases	28
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	28
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition	28
Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy	27
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	27
Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics	27
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	27
Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling	27
New drug approvals for 2022: Synthesis and clinical applications	26
Dissecting the pleiotropic roles of reactive oxygen species (ROS) in lung cancer: From carcinogenesis toward therapy	26
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases	26
Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies	25
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	24
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections	24
Connecting the dots: Targeting the microbiome in drug toxicity	23
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	23
Inside Front Cover Image, Volume 41, Issue 3	23
Bioactive atropisomers: Unraveling design strategies and synthetic routes for drug discovery	23
Front Cover Image, Volume 41, Issue 3	23
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection	22
Chemo‐proteomics in antimalarial target identification and engagement	22
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(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy	21
Pipeline of anti‐Mycobacterium abscessussmall molecules: Repurposable drugs and promising novel chemical entities	20
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The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	19
Cardiovascular therapeutics: A new potential for anxiety treatment?	19
Fast and furious: The neutrophil and its armamentarium in health and disease	19
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	19
Inside Front Cover Image, Volume 44, Issue 2	18
Recent insights in the PI3K/Akt pathway as a promising therapeutic target in combination with EGFR‐targeting agents to treat head and neck squamous cell carcinoma	18
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	18
Chemistry and biological activity of resin glycosides from Convolvulaceae species	17
Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases	17
Elimination of the hepatitis B virus: A goal, a challenge	17
Analyzing the scaffold diversity of cyclin‐dependent kinase inhibitors and revisiting the clinical and preclinical pipeline	17
Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease	17

Fluorescent imaging probes for in vivo ovarian cancer targeted detection and surgery	16
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	16
Perspectives on pain in Down syndrome	16
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport	15
Dual‐target inhibitors of bromodomain and extra‐terminal proteins in cancer: A review from medicinal chemistry perspectives	15
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	15
Emerging roles of microRNA‐208a in cardiology and reverse cardio‐oncology	15
Front Cover Image, Volume 44, Issue 6	15
Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses	14
Insights into Ganoderma fungi meroterpenoids opening a new era of racemic natural products in mushrooms	14
Applications of medicinal chemistry for drug discovery against Acanthamoeba infections	14
Biologically active secoiridoids: A comprehensive update	13
Front Cover Image, Volume 45, Issue 1	13
Extracellular vesicles: Emerging frontiers in wound healing	13
The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	13
Targeting tumor microenvironment with photodynamic nanomedicine	13
Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment	13
Histone deacetylase‐based dual targeted inhibition in multiple myeloma	13
Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety	13
Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update	12
The new direction of drug development: Degradation of undruggable targets through targeting chimera technology	12
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	12
Computational benchmarking of putative KIFC1 inhibitors	12
Purinergic receptors modulators: An emerging pharmacological tool for disease management	11
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	11
GADD45A: With or without you	11
Human mpox: Biology, epidemiology, therapeutic options, and development of small molecule inhibitors	11
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	11
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	10
Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review	10
Neuroprotective, neurogenic, and anticholinergic evidence ofGanoderma lucidumcognitive effects: Crucial knowledge is still lacking	10
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	10
Current and emerging approaches to noncompetitive AR inhibition	10
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Corrigendum: Molecular targeting therapies for neuroblastoma: Progress and challenges	9
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Trends in targeted delivery of nanomaterials in colon cancer diagnosis and treatment	9
H+‐slip correlated to rotor free‐wheeling as cause of F1FO‐ATPase dysfunction in primary mitochondrial disorders	8
The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	8
Back Cover Image, Volume 41, Issue 3	8
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Inside Front Cover Image, Volume 41, Issue 4	8
Front Cover Image, Volume 42, Issue 4	7
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	7
Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective	7
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Genetically modified cancer vaccines: Current status and future prospects	7
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Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi‐active components combination	7
Front Cover Image, Volume 42, Issue 3	6
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Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	6
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Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective	6
A review in radiomics: Making personalized medicine a reality via routine imaging	6
Current nanocomposite advances for biomedical and environmental application diversity	6
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Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	6
Association predictions of genomics, proteinomics, transcriptomics, microbiome, metabolomics, pathomics, radiomics, drug, symptoms, environment factor, and disease networks: A comprehensive approach	6
The adenosinergic pathway in mesenchymal stem cell fate and functions	5
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	5
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	5
1,3‐Diazepine: A privileged scaffold in medicinal chemistry	5
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	5
Front Cover Image, Volume 44, Issue 5	5
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	5
Mitochondrial quality control proteases and their modulation for cancer therapy	5
Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies	5
Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response	5
Therapeutic potential of salicylamide derivatives for combating viral infections	5
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Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	4
Antioxidant peptides, the guardian of life from oxidative stress	4
Engineering peptide drug therapeutics through chemical conjugation and implication in clinics	4
Targeting the HSP90–CDC37–kinase chaperone cycle: A promising therapeutic strategy for cancer	4
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines	4
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases	4

Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets	4
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	4
B‐cell lymphoma‐2 family proteins in the crosshairs: Small molecule inhibitors and activators for cancer therapy	4
Leveraging the ATP‐P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications	4
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	4
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	4