Medicinal Research Reviews

Article	Citations
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Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	159
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	151
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	129
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	119
Galectin‐8 inhibition and functions in immune response and tumor biology	105
New drug approvals for 2022: Synthesis and clinical applications	105
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	103
Key characters of glycodrugs	86
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	83
Front Cover Image, Volume 45, Issue 1	78
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	76
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	72
Current and emerging approaches to noncompetitive AR inhibition	72
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	71
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	70
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	65
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	64
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	61
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	61
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	60
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	58
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	56

α‐Synuclein in Parkinson's Disease: From Bench to Bedside	53
Enhancing healthy aging with small molecules: A mitochondrial perspective	53
Mitochondrial quality control proteases and their modulation for cancer therapy	51
Emerging roles of nerve‐bone axis in modulating skeletal system	42
Current nanocomposite advances for biomedical and environmental application diversity	39
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Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy	37
Human Cyclophilins—An Emerging Class of Drug Targets	37
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	37
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	36
Inside Front Cover Image, Volume 44, Issue 5	34
Advances in reversible covalent kinase inhibitors	34
Targeting epigenetic modifications in Parkinson's disease therapy	32
An overview of the progress made in research into the Mpox virus	31
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	29
LSD1 in drug discovery: From biological function to clinical application	29
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	29
ER stress and inflammation crosstalk in obesity	28
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	28
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases	28
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	28
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Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications	27
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	27
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Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	26
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The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches	26
Harnessing the Power of Natural Products for Targeted Protein Degradation	25
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	25
Cardiovascular therapeutics: A new potential for anxiety treatment?	25
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	25
Computational benchmarking of putative KIFC1 inhibitors	25
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	25
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	25
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	24
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	24
Chemistry and biological activity of resin glycosides from Convolvulaceae species	24
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Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	22
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	21
Genetically modified cancer vaccines: Current status and future prospects	21
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	20
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Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	20

H+‐slip correlated to rotor free‐wheeling as cause of F1FO‐ATPase dysfunction in primary mitochondrial disorders	20
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Front Cover Image, Volume 45, Issue 4	20
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	20
Advances in machine intelligence‐driven virtual screening approaches for big‐data	19
Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy	19
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Comprehensive Insights Into Sulfanilamido‐Based Medicinal Design and Research	18
Incomplete autophagy: Trouble is a friend	18
Recent Developments in the Optical Control of Adrenergic Signaling	18
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Cuproptosis: Mechanism, role, and advances in urological malignancies	17
Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?	17
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Poly (adenosine diphosphate‐ribose) polymerase inhibitors in the treatment of triple‐negative breast cancer with homologous repair deficiency	17
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy	17
Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases	17
Epigenetic modifications in pancreas development, diabetes, and therapeutics	16
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology	16
Covalent Bifunctional Molecules (CBMs): Achievements and Challenges	16
Unleashing the Power of Covalent Drugs for Protein Degradation	16
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	15
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors	15
Near‐Infrared Fluorescent Probe for the Early Diagnosis of Alzheimer's Disease	15
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections	14
Extracellular vesicles: Emerging frontiers in wound healing	14
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	14
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The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	14
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	14
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport	14
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	14
Chemo‐proteomics in antimalarial target identification and engagement	13
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	13
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	13
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	13
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Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective	12
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	12
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Front Cover Image, Volume 44, Issue 5	12
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective	12
Recent Progress in Azobenzene‐Based In Vivo Photopharmacology	12
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Unrevealing the connection between real sample analysis and analytical method. The case of cytokines	12
Pyroptosis and the fight against lung cancer	12
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases	12
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin	11
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Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets	11
Therapeutic Potential of Vascular Adhesion Protein‐1 (VAP‐1)/Semicarbazide‐Sensitive Amine Oxidase (SSAO) Inhibitors: Current Medicinal Chemistry and Emerging Opportunities	11
The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex	11
Parkin exerts the tumor‐suppressive effect through targeting mitochondria	11
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Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases	10
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The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer	10
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras	10
The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications	10
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance	10
Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy	10
How Artificial Intelligence Assists in Overcoming Drug Resistance?	9
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates	9
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Advanced models for respiratory disease and drug studies	9
Beyond dopamine: Novel strategies for schizophrenia treatment	9
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer	9
Progress and perspective on hydrogen sulfide donors and their biomedical applications	9
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management	9
Front Cover Image, Volume 43, Issue 6	8
β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo	8
Natural products as Zika antivirals	8
Activation and inhibition of sirtuins: From bench to bedside	8
Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy	8
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases	8
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders	8

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The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications	8