Medicinal Research Reviews

Article	Citations
	437
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	184
New drug approvals for 2022: Synthesis and clinical applications	157
	128
Key characters of glycodrugs	123
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	123
Galectin‐8 inhibition and functions in immune response and tumor biology	114
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	111
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	93
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	92
Issue Information	86
Current and emerging approaches to noncompetitive AR inhibition	82
Front Cover Image, Volume 45, Issue 1	79
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	78
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	72
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	69
Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review	64
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	59
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	59
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	58
Mitochondrial quality control proteases and their modulation for cancer therapy	58
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	55
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	54
Association predictions of genomics, proteinomics, transcriptomics, microbiome, metabolomics, pathomics, radiomics, drug, symptoms, environment factor, and disease networks: A comprehensive approach	54
Enhancing healthy aging with small molecules: A mitochondrial perspective	54

Current nanocomposite advances for biomedical and environmental application diversity	53
Inside Front Cover Image, Volume 41, Issue 4	53
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	47
Emerging roles of nerve‐bone axis in modulating skeletal system	46
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	46
Issue Information	44
Issue Information	41
The role of Wnt signaling in skin fibrosis	41
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	41
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	37
Inside Front Cover Image, Volume 44, Issue 5	36
An overview of the progress made in research into the Mpox virus	36
Targeting epigenetic modifications in Parkinson's disease therapy	35
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	33
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	33
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Advances in reversible covalent kinase inhibitors	32
LSD1 in drug discovery: From biological function to clinical application	32
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	31
Recent pharmacological advances in the repurposing of artemisinin drugs	31
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	31
Artemisinin‐derived dimers from a chemical perspective	30
ER stress and inflammation crosstalk in obesity	30
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	29
The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	29
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	29
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	28
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Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	25
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	25
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	24
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	23
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	23
Corrigendum: Molecular targeting therapies for neuroblastoma: Progress and challenges	23
Computational benchmarking of putative KIFC1 inhibitors	23
Chemistry and biological activity of resin glycosides from Convolvulaceae species	22
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Cardiovascular therapeutics: A new potential for anxiety treatment?	21
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	21
Harnessing the Power of Natural Products for Targeted Protein Degradation	21
Issue Information	21
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	21
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	20
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Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	20
H+‐slip correlated to rotor free‐wheeling as cause of F1FO‐ATPase dysfunction in primary mitochondrial disorders	20
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	19
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	19

Issue Information	19
Genetically modified cancer vaccines: Current status and future prospects	19
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Incomplete autophagy: Trouble is a friend	16
Recent Developments in the Optical Control of Adrenergic Signaling	16
Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy	16
In honor of Professor Youyou Tu on the occasion of her 90th birthday	16
Advances in machine intelligence‐driven virtual screening approaches for big‐data	16
Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?	15
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The lymphatic vasculature: An active and dynamic player in cancer progression	15
Poly (adenosine diphosphate‐ribose) polymerase inhibitors in the treatment of triple‐negative breast cancer with homologous repair deficiency	15
Cuproptosis: Mechanism, role, and advances in urological malignancies	15
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Unleashing the Power of Covalent Drugs for Protein Degradation	14
Issue Information	14
Epigenetic modifications in pancreas development, diabetes, and therapeutics	14
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Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy	14
Structural insights into the distinctive RNA recognition and therapeutic potentials of RIG‐I‐like receptors	14
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	14
Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases	14
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology	14
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	14
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition	13
Autosomic dominant polycystic kidney disease and metformin: Old knowledge and new insights on retarding progression of chronic kidney disease	13
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	13
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors	13
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	12
Chemo‐proteomics in antimalarial target identification and engagement	12
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections	12
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The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	12
Extracellular vesicles: Emerging frontiers in wound healing	11
Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses	11
Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update	11
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	11
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport	11
Issue Information	10
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines	10
Front Cover Image, Volume 44, Issue 5	10
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	10
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	10
Issue Information	10
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Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective	10
Issue Information	10
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	9
The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex	9
Mechanism of activation and the rewired network: New drug design concepts	9
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin	9
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective	9
Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets	9
Issue Information	9
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer	9
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance	9
Issue Information	9
A review in radiomics: Making personalized medicine a reality via routine imaging	9
Pyroptosis and the fight against lung cancer	9
The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications	9
Parkin exerts the tumor‐suppressive effect through targeting mitochondria	9
Combining stem cells in myocardial infarction: The road to superior repair?	9
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases	9
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases	9
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer	8
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras	8
Advanced models for respiratory disease and drug studies	8
Natural products as geroprotectors: An autophagy perspective	8
Beyond dopamine: Novel strategies for schizophrenia treatment	8
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Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates	7
Application or function of citric acid in drug delivery platforms	7
Back Cover Image, Volume 41, Issue 6	7
Progress and perspective on hydrogen sulfide donors and their biomedical applications	7
Front Cover Image, Volume 43, Issue 6	7
Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy	7
Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies	6

Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy	6
Estrogen deficiency‐mediated osteoimmunity in postmenopausal osteoporosis	6
Activation and inhibition of sirtuins: From bench to bedside	6
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders	6
β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo	6
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Natural products as Zika antivirals	6
The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications	6