Medicinal Research Reviews

Article	Citations
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications	320
Molecular targeting therapies for neuroblastoma: Progress and challenges	177
The role of hypoxia‐inducible factor 1 in tumor immune evasion	173
Understanding the tumor microenvironment for effective immunotherapy	164
Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions	164
Mechanisms of melanocyte death in vitiligo	136
A review in radiomics: Making personalized medicine a reality via routine imaging	128
Tripterygium wilfordii: An inspiring resource for rheumatoid arthritis treatment	120
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections	105
Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali Radix)	98
The immunosuppressive activity of artemisinin‐type drugs towards inflammatory and autoimmune diseases	94
Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: A therapeutic target to control intestinal inflammation	88
Emerging roles of SIRT6 in human diseases and its modulators	86
What coronavirus 3C‐like protease tells us: From structure, substrate selectivity, to inhibitor design	85
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases	75
Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments	75
The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy	71
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	70
Direct targeting of β‐catenin in the Wnt signaling pathway: Current progress and perspectives	68
Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review	66
Extracellular vesicles: Emerging frontiers in wound healing	63
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	63
Strategies for designing proteolysis targeting chimaeras (PROTACs)	59
Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update	53
(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy	52

Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease	52
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition	51
Cardiac efficacy and toxicity of aconitine: A new frontier for the ancient poison	50
Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets	50
Cistanches Herba, from an endangered species to a big brand of Chinese medicine	48
Trends in targeted delivery of nanomaterials in colon cancer diagnosis and treatment	48
Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol	46
Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness	46
Inflammatory bowel disease biomarkers	45
The Yin and Yang of traditional Chinese and Western medicine	44
Association predictions of genomics, proteinomics, transcriptomics, microbiome, metabolomics, pathomics, radiomics, drug, symptoms, environment factor, and disease networks: A comprehensive approach	44
Progress and perspective on hydrogen sulfide donors and their biomedical applications	42
Protein corona formed in the gastrointestinal tract and its impacts on oral delivery of nanoparticles	42
Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants	41
Salinomycin as a potent anticancer stem cell agent: State of the art and future directions	40
SARS‐CoV‐2‐mediated immune system activation and potential application in immunotherapy	39
Pipeline of anti‐Mycobacterium abscessussmall molecules: Repurposable drugs and promising novel chemical entities	38
Targeting the HSP90–CDC37–kinase chaperone cycle: A promising therapeutic strategy for cancer	38
Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response	37
Drug design targeting active posttranslational modification protein isoforms	37
Current status and future prospects of nanomedicine for arsenic trioxide delivery to solid tumors	37
Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling	36
The role of Wnt signaling in skin fibrosis	35
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	32
Dual‐target inhibitors of bromodomain and extra‐terminal proteins in cancer: A review from medicinal chemistry perspectives	31
Antioxidant peptides, the guardian of life from oxidative stress	30
Adipose‐derived stromal cells for nonhealing wounds: Emerging opportunities and challenges	30
NLRP3 inflammasome in cardiovascular diseases: Pathophysiological and pharmacological implications	30
Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin	30
The role of long noncoding RNA in lipid, cholesterol, and glucose metabolism and treatment of obesity syndrome	30
Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies	29
Drug repurposing approach to combating coronavirus: Potential drugs and drug targets	29
The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases	29
Recent insights in the PI3K/Akt pathway as a promising therapeutic target in combination with EGFR‐targeting agents to treat head and neck squamous cell carcinoma	28
Recent pharmacological advances in the repurposing of artemisinin drugs	28
Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective	28
A potential therapeutic strategy for prostatic disease by targeting the oral microbiome	27
Microglia‐derived galectin‐3 in neuroinflammation; a bittersweet ligand?	27
Combining stem cells in myocardial infarction: The road to superior repair?	27
ER stress and inflammation crosstalk in obesity	27
Druggability modification strategies of the diarylpyrimidine‐type non‐nucleoside reverse transcriptase inhibitors	27
Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses	26
Analyzing the scaffold diversity of cyclin‐dependent kinase inhibitors and revisiting the clinical and preclinical pipeline	26
Incomplete autophagy: Trouble is a friend	26
Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges	25
The antigen‐binding moiety in the driver's seat of CARs	25
Artemisinin‐derived dimers from a chemical perspective	24
Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors	24
Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics	24
Ribosome‐targeting antibacterial agents: Advances, challenges, and opportunities	23

1,3‐Diazepine: A privileged scaffold in medicinal chemistry	23
Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment	23
The lymphatic vasculature: An active and dynamic player in cancer progression	23
Mitochondrial quality control proteases and their modulation for cancer therapy	23
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	23
Recent progresses and remaining challenges for the detection of Zika virus	23
Small molecules as modulators of regulated cell death against ischemia/reperfusion injury	22
Epigenetic modifications in pancreas development, diabetes, and therapeutics	22
Targeted nanomedicines for the treatment of bone disease and regeneration	21
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance	20
Emerging insights on the role of V‐ATPase in human diseases: Therapeutic challenges and opportunities	20
Crystallographic landscape of SHP2 provides molecular insights for SHP2 targeted drug discovery	20
Application or function of citric acid in drug delivery platforms	19
Therapeutic targets and potential agents for the treatment of COVID‐19	19
Propolis: A useful agent on psychiatric and neurological disorders? A focus on CAPE and pinocembrin components	19
Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi‐active components combination	19
Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases	19
Applications of medicinal chemistry for drug discovery against Acanthamoeba infections	19
Mesenchymal stromal cell therapy for pancreatitis: Progress and challenges	18
Recent developments in controlling sternal wound infection after cardiac surgery and measures to enhance sternal healing	18
How selective are clinical CDK4/6 inhibitors?	18
Natural products as Zika antivirals	18
Revisiting prostate cancer metabolism: From metabolites to disease and therapy	18
Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery	18
Repurposing drugs to fight aging: The difficult path from bench to bedside	17
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	17
The newly discovered role of endocytosis in artemisinin resistance	17
Mechanism of activation and the rewired network: New drug design concepts	17
QcrB in Mycobacterium tuberculosis: The new drug target of antitubercular agents	17
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	17
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin	16
Recent advances in proteome‐wide label‐free target deconvolution for bioactive small molecules	16
The adenosinergic pathway in mesenchymal stem cell fate and functions	16
Peroral targeting of drug micro or nanocarriers to sites beyond the gastrointestinal tract	15
MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies	15
Connecting the dots: Targeting the microbiome in drug toxicity	15
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer	15
New drug approvals for 2022: Synthesis and clinical applications	15
Purinergic receptors modulators: An emerging pharmacological tool for disease management	14
An overview of cdc2‐like kinase 1 (Clk1) inhibitors and their therapeutic indications	14
The biology and inhibition of glucose‐regulated protein 94/gp96	14
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders	13
Neurodegenerative disorders—Searching for targets and new ways of diseases treatment	13
Chemo‐proteomics in antimalarial target identification and engagement	13
Cell transplantation and secretome based approaches in spinal cord injury regenerative medicine	13
Toward the next generation of vascularized human neural organoids	13
Microscopy based methods for characterization, drug delivery, and understanding the dynamics of nanoparticles	13
Epigenetic modification in alcohol‐related liver diseases	13
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	12
The tumor microenvironment in the postsurgical liver: Mechanisms and potential targets of postoperative recurrence in human hepatocellular carcinoma	12
Structural insights into the distinctive RNA recognition and therapeutic potentials of RIG‐I‐like receptors	12
β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo	12
FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid	12
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	12
Recent progress and structural analyses of domain‐selective BET inhibitors	11
Cardiovascular therapeutics: A new potential for anxiety treatment?	11
New insight into the application of fluorescence platforms in tumor diagnosis: From chemical basis to clinical application	11
The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases	11
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	11
Targeting epigenetic modifications in Parkinson's disease therapy	10
Regulation of beta‐amyloid for the treatment of Alzheimer's disease: Research progress of therapeutic strategies and bioactive compounds	10
Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases	10
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	10
Exploring and exploiting plant cyclic peptides for drug discovery and development	9
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	9
Natural products as geroprotectors: An autophagy perspective	9
The regulatory factors and pathological roles of autophagy‐related protein 4 in diverse diseases: Recent research advances	8
Chemistry and biological activity of resin glycosides from Convolvulaceae species	8
The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites	8
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates	8
Autosomic dominant polycystic kidney disease and metformin: Old knowledge and new insights on retarding progression of chronic kidney disease	8
Mutual leveraging of proximity effects and click chemistry in chemical biology	8
Genetically modified cancer vaccines: Current status and future prospects	8
Atremorine in Parkinson's disease: From dopaminergic neuroprotection to pharmacogenomics	7
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	7
Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy	7
A medicinal chemist who reshaped the antiviral drug industry: John Charles Martin (1951–2021)	7
Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications utilizing adeno‐associated viral vectors	7
Fast and furious: The neutrophil and its armamentarium in health and disease	7
Diverse biological functions of the renin‐angiotensin system	7

Leveraging the ATP‐P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications	7
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	7
Human mpox: Biology, epidemiology, therapeutic options, and development of small molecule inhibitors	6
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	6
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	6
Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation	6
Neuroprotective, neurogenic, and anticholinergic evidence ofGanoderma lucidumcognitive effects: Crucial knowledge is still lacking	6
Insights into Ganoderma fungi meroterpenoids opening a new era of racemic natural products in mushrooms	6
The modern view on the role of glyprolines by metabolic syndrome	6
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	6
The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	6
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	6
CYP1A inhibitors: Recent progress, current challenges, and future perspectives	6
Optimizing clinical research procedures in public health emergencies	6
An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes	5
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology	5
Biologically active secoiridoids: A comprehensive update	5
Isolation, chemistry, and biology of pyrrolo[1,4]benzodiazepine natural products	5
Advanced models for respiratory disease and drug studies	5
Histone deacetylase‐based dual targeted inhibition in multiple myeloma	5
Parkin exerts the tumor‐suppressive effect through targeting mitochondria	5
Enzymes in the time of COVID‐19: An overview about the effects in the human body, enzyme market, and perspectives for new drugs	5
Computational benchmarking of putative KIFC1 inhibitors	5
Dissecting the pleiotropic roles of reactive oxygen species (ROS) in lung cancer: From carcinogenesis toward therapy	5