Medicinal Research Reviews

Article	Citations
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Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	153
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	146
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	139
Galectin‐8 inhibition and functions in immune response and tumor biology	118
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Key characters of glycodrugs	101
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	95
New drug approvals for 2022: Synthesis and clinical applications	94
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	84
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	79
Front Cover Image, Volume 45, Issue 1	71
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	70
Current and emerging approaches to noncompetitive AR inhibition	69
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	68
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	68
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	67
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	63
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	59
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	57
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	55
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	54
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	52
Emerging roles of nerve‐bone axis in modulating skeletal system	50

Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	50
Mitochondrial quality control proteases and their modulation for cancer therapy	49
Current nanocomposite advances for biomedical and environmental application diversity	46
Enhancing healthy aging with small molecules: A mitochondrial perspective	43
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	40
Issue Information	39
Inside Front Cover Image, Volume 44, Issue 5	35
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Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	35
Advances in reversible covalent kinase inhibitors	35
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	35
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	34
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	34
An overview of the progress made in research into the Mpox virus	33
Targeting epigenetic modifications in Parkinson's disease therapy	32
LSD1 in drug discovery: From biological function to clinical application	31
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CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	29
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	29
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	28
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ER stress and inflammation crosstalk in obesity	27
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Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	26
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	25
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	25
Issue Information	25
Cardiovascular therapeutics: A new potential for anxiety treatment?	24
Chemistry and biological activity of resin glycosides from Convolvulaceae species	24
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	24
Harnessing the Power of Natural Products for Targeted Protein Degradation	24
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	24
Computational benchmarking of putative KIFC1 inhibitors	24
Issue Information	23
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	23
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A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	23
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	22
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A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	22
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	22
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	22
H+‐slip correlated to rotor free‐wheeling as cause of F1FO‐ATPase dysfunction in primary mitochondrial disorders	22
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	21
Front Cover Image, Volume 45, Issue 4	21
Genetically modified cancer vaccines: Current status and future prospects	21
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In honor of Professor Youyou Tu on the occasion of her 90th birthday	20

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Incomplete autophagy: Trouble is a friend	20
Issue Information	20
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Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy	20
Comprehensive Insights Into Sulfanilamido‐Based Medicinal Design and Research	18
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Recent Developments in the Optical Control of Adrenergic Signaling	18
Advances in machine intelligence‐driven virtual screening approaches for big‐data	18
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy	17
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The lymphatic vasculature: An active and dynamic player in cancer progression	17
Cuproptosis: Mechanism, role, and advances in urological malignancies	17
Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?	17
Poly (adenosine diphosphate‐ribose) polymerase inhibitors in the treatment of triple‐negative breast cancer with homologous repair deficiency	17
Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases	16
Epigenetic modifications in pancreas development, diabetes, and therapeutics	16
Issue Information	16
Unleashing the Power of Covalent Drugs for Protein Degradation	16
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology	16
Near‐Infrared Fluorescent Probe for the Early Diagnosis of Alzheimer's Disease	16
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors	15
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections	15
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	15
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	15
Covalent Bifunctional Molecules (CBMs): Achievements and Challenges	15
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition	14
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	14
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Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	14
The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	13
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	13
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport	12
Issue Information	12
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Chemo‐proteomics in antimalarial target identification and engagement	12
Extracellular vesicles: Emerging frontiers in wound healing	12
Issue Information	12
Recent Progress in Azobenzene‐Based In Vivo Photopharmacology	12
Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses	12
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	12
Front Cover Image, Volume 44, Issue 5	12
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective	12
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	12
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	11
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases	11
The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex	11
Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets	11
Pyroptosis and the fight against lung cancer	11
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines	11
Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective	11
Issue Information	11
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer	10
Therapeutic Potential of Vascular Adhesion Protein‐1 (VAP‐1)/Semicarbazide‐Sensitive Amine Oxidase (SSAO) Inhibitors: Current Medicinal Chemistry and Emerging Opportunities	10
Parkin exerts the tumor‐suppressive effect through targeting mitochondria	10
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance	10
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin	10
The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications	10
Issue Information	10
Mechanism of activation and the rewired network: New drug design concepts	10
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases	10
Issue Information	10
Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy	9
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates	9
Advanced models for respiratory disease and drug studies	9
Progress and perspective on hydrogen sulfide donors and their biomedical applications	9
How Artificial Intelligence Assists in Overcoming Drug Resistance?	9
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras	9
Back Cover Image, Volume 41, Issue 6	8
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer	8
Front Cover Image, Volume 43, Issue 6	8
Beyond dopamine: Novel strategies for schizophrenia treatment	8
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Application or function of citric acid in drug delivery platforms	8
Activation and inhibition of sirtuins: From bench to bedside	7
Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy	7
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases	7
β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo	7
The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications	7

Natural products as Zika antivirals	7
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders	7
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Estrogen deficiency‐mediated osteoimmunity in postmenopausal osteoporosis	7