Medicinal Research Reviews

Papers
(The median citation count of Medicinal Research Reviews is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)
ArticleCitations
183
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery168
159
Key characters of glycodrugs153
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Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders120
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy113
The role and prospect of lysine‐specific demethylases in cancer chemoresistance103
New drug approvals for 2022: Synthesis and clinical applications102
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment97
Galectin‐8 inhibition and functions in immune response and tumor biology85
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers81
Front Cover Image, Volume 45, Issue 173
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective72
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents72
Current and emerging approaches to noncompetitive AR inhibition71
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders70
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel70
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses67
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer61
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases59
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing59
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review58
Emerging roles of nerve‐bone axis in modulating skeletal system57
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases54
Enhancing healthy aging with small molecules: A mitochondrial perspective52
α‐Synuclein in Parkinson's Disease: From Bench to Bedside51
Current nanocomposite advances for biomedical and environmental application diversity48
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators47
Mitochondrial quality control proteases and their modulation for cancer therapy46
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Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis36
Inside Front Cover Image, Volume 44, Issue 536
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds36
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis35
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future35
Advances in reversible covalent kinase inhibitors35
An overview of the progress made in research into the Mpox virus34
Targeting epigenetic modifications in Parkinson's disease therapy34
ER stress and inflammation crosstalk in obesity31
LSD1 in drug discovery: From biological function to clinical application31
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives29
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects29
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery29
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Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide27
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Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography26
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents26
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands26
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications26
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity25
Cardiovascular therapeutics: A new potential for anxiety treatment?25
Computational benchmarking of putative KIFC1 inhibitors25
Harnessing the Power of Natural Products for Targeted Protein Degradation25
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development24
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage24
Issue Information24
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics24
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology24
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Chemistry and biological activity of resin glycosides from Convolvulaceae species24
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective23
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential23
Genetically modified cancer vaccines: Current status and future prospects23
Front Cover Image, Volume 45, Issue 423
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H+‐slip correlated to rotor free‐wheeling as cause of F1FO‐ATPase dysfunction in primary mitochondrial disorders23
Issue Information22
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications22
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Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy20
In honor of Professor Youyou Tu on the occasion of her 90th birthday20
Advances in machine intelligence‐driven virtual screening approaches for big‐data19
Comprehensive Insights Into Sulfanilamido‐Based Medicinal Design and Research19
Recent Developments in the Optical Control of Adrenergic Signaling19
Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?18
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy18
Poly (adenosine diphosphate‐ribose) polymerase inhibitors in the treatment of triple‐negative breast cancer with homologous repair deficiency18
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Cuproptosis: Mechanism, role, and advances in urological malignancies18
Incomplete autophagy: Trouble is a friend18
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Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases18
Covalent Bifunctional Molecules (CBMs): Achievements and Challenges17
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology17
Near‐Infrared Fluorescent Probe for the Early Diagnosis of Alzheimer's Disease17
Unleashing the Power of Covalent Drugs for Protein Degradation17
Issue Information17
Epigenetic modifications in pancreas development, diabetes, and therapeutics16
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies16
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders16
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors16
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections15
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition15
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Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands15
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives14
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions14
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport14
Extracellular vesicles: Emerging frontiers in wound healing14
Chemo‐proteomics in antimalarial target identification and engagement13
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution13
The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis13
Issue Information13
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management13
Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses13
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines12
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Pyroptosis and the fight against lung cancer12
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Artemisinins: Promising drug candidates for the treatment of autoimmune diseases12
Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective12
Front Cover Image, Volume 44, Issue 512
Recent Progress in Azobenzene‐Based In Vivo Photopharmacology12
Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets12
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective12
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin11
Mechanism of activation and the rewired network: New drug design concepts11
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease11
Parkin exerts the tumor‐suppressive effect through targeting mitochondria11
The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex11
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The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications10
How Artificial Intelligence Assists in Overcoming Drug Resistance?10
Therapeutic Potential of Vascular Adhesion Protein‐1 (VAP‐1)/Semicarbazide‐Sensitive Amine Oxidase (SSAO) Inhibitors: Current Medicinal Chemistry and Emerging Opportunities10
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance10
Advanced models for respiratory disease and drug studies10
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras10
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer10
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Beyond dopamine: Novel strategies for schizophrenia treatment10
Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy10
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases10
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders9
Back Cover Image, Volume 41, Issue 69
Application or function of citric acid in drug delivery platforms9
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management9
Front Cover Image, Volume 43, Issue 69
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer9
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Progress and perspective on hydrogen sulfide donors and their biomedical applications9
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates9
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Activation and inhibition of sirtuins: From bench to bedside8
Estrogen deficiency‐mediated osteoimmunity in postmenopausal osteoporosis8
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