Medicinal Research Reviews

Article	Citations
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	216
In Memoriam: Professor Minyong Li (1976–2025)	197
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	174
Key characters of glycodrugs	153
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	123
New drug approvals for 2022: Synthesis and clinical applications	118
Accelerating Small Molecule Ferroptosis Regulator Development With Advances in Biological Functions	113
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	96
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	96
Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns	92
Galectin‐8 inhibition and functions in immune response and tumor biology	91
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	90
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria	85
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	84
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Front Cover Image, Volume 45, Issue 1	83
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	77
Current and emerging approaches to noncompetitive AR inhibition	77
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	65
Issue Information	65
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	65
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	50
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	47
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	44

Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	43
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	43
Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery	43
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	40
Mitochondrial quality control proteases and their modulation for cancer therapy	40
Current nanocomposite advances for biomedical and environmental application diversity	40
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	40
Emerging roles of nerve‐bone axis in modulating skeletal system	39
A Possibility of Synthetic Lethality: Wee1 Kinase as a Promising Treating Target for Cancer	37
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	37
Enhancing healthy aging with small molecules: A mitochondrial perspective	37
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	36
Issue Information	36
Human Cyclophilins—An Emerging Class of Drug Targets	35
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	35
An overview of the progress made in research into the Mpox virus	34
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy	34
Inside Front Cover Image, Volume 44, Issue 5	34
Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000–2025)	34
Targeting epigenetic modifications in Parkinson's disease therapy	33
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	33
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	33
Advances in reversible covalent kinase inhibitors	32
LSD1 in drug discovery: From biological function to clinical application	32
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases	31
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	31
ER stress and inflammation crosstalk in obesity	30
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	29
Issue Information	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	29
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CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	29
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches	28
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Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	27
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	27
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	26
Kinin B 1 and B 2 Receptors: Role in Tumor Progression and Pain Associated With Tumor and Anticanc	26
Computational benchmarking of putative KIFC1 inhibitors	25
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications	25
Quantification of 10 B and 11 B in Biological Samples in Translational Science and Clinical Applic	25
Chemistry and biological activity of resin glycosides from Convolvulaceae species	24
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	23
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A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	23
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	23
Harnessing the Power of Natural Products for Targeted Protein Degradation	23
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Issue Information	23

Front Cover Image, Volume 45, Issue 4	23
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	22
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	22
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	22
Targeting ClpP Protease: Emerging Therapeutic Strategies and Small‐Molecule Modulators in Drug Discovery	22
Medicinal Chemistry Strategies for the Development of CD73 Inhibitors in Cancer Immunotherapy	22
H+‐slip correlated to rotor free‐wheeling as cause of F1FO‐ATPase dysfunction in primary mitochondrial disorders	21
Tirzepatide in Metabolic Diseases: Clinical Efficacy and Safety Beyond Diabetes and Obesity	21
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	21
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Issue Information	20
Advances in machine intelligence‐driven virtual screening approaches for big‐data	19
Poly (adenosine diphosphate‐ribose) polymerase inhibitors in the treatment of triple‐negative breast cancer with homologous repair deficiency	19
Recent Developments in the Optical Control of Adrenergic Signaling	19
Advances in SIRT2‐Targeted Therapeutics: Structural Insights, Chemical Strategies, and Degrader Technologies	19
Comprehensive Insights Into Sulfanilamido‐Based Medicinal Design and Research	19
Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy	19
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Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?	18
Synthesis and Clinical Application of Small‐Molecule Drugs Approved by FDA in 2025	18
Issue Information	18
Cuproptosis: Mechanism, role, and advances in urological malignancies	18
Covalent Bifunctional Molecules (CBMs): Achievements and Challenges	18
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy	18
Mucin O‐Glycosylation and Mucolytic Therapies in Pseudomyxoma Peritonei: Literature Review	18
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology	17
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Recent Advances of Non‐Nucleoside Polymerase Inhibitors With Broad‐Spectrum Antiviral Activities	16
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	16
Near‐Infrared Fluorescent Probe for the Early Diagnosis of Alzheimer's Disease	16
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors	16
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	16
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	16
Unleashing the Power of Covalent Drugs for Protein Degradation	16
Insights From Spatiality: Accelerating Pharmaceutical Research Using Mass Spectrometry Imaging	15
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	15
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport	15
Extracellular vesicles: Emerging frontiers in wound healing	15
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	15
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	15
Issue Information	14
Chemo‐proteomics in antimalarial target identification and engagement	14
Issue Information	14
Front Cover Image, Volume 44, Issue 5	14
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	14
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The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	14
Issue Information	13
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases	13
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Recent Progress in Azobenzene‐Based In Vivo Photopharmacology	13
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	12
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?	12
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective	12
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines	12
Pyroptosis and the fight against lung cancer	12
The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications	11
Issue Information	11
The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex	11
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases	11
Issue Information	11
Therapeutic Potential of Vascular Adhesion Protein‐1 (VAP‐1)/Semicarbazide‐Sensitive Amine Oxidase (SSAO) Inhibitors: Current Medicinal Chemistry and Emerging Opportunities	11
How Artificial Intelligence Assists in Overcoming Drug Resistance?	10
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin	10
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer	10
Parkin exerts the tumor‐suppressive effect through targeting mitochondria	10
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance	10
Issue Information	10
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer	10
Advanced models for respiratory disease and drug studies	9
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras	9
Beyond dopamine: Novel strategies for schizophrenia treatment	9
Immunosuppressive Tumor Microenvironment and Therapeutic Landscape of Diffuse Intrinsic Pontine Glioma	9
Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy	9
Progress and perspective on hydrogen sulfide donors and their biomedical applications	9
Front Cover Image, Volume 43, Issue 6	8
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management	8

Activation and inhibition of sirtuins: From bench to bedside	8
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates	8
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