Neurobiology of Aging

Article	Citations
Are sex differences in cognitive impairment reflected in epigenetic age acceleration metrics?	338
Region-specific and age-related differences in astrocytes in the human brain	118
Age-related differences in functional connectivity associated with pain modulation	115
Chronic BMAA exposure combined with TDP-43 mutation elicits motor neuron dysfunction phenotypes in mice	68
Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease	64
The association between personality and plasma biomarkers of astrogliosis and neuronal injury	61
Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes	58
Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice	43
The genetic overlap between Alzheimer’s disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson’s disease	42
Sex differences in the IntelliCage and the Morris water maze in the APP/PS1 mouse model of amyloidosis	42
Generating diagnostic profiles of cognitive decline and dementia using magnetoencephalography	42
Role and molecular regulatory mechanisms of Hippo signaling pathway in Caenorhabditis elegans and mammalian cell models of Alzheimer’s disease	41
Lack of evidence for association of UQCRC1 with Parkinson's disease in Europeans	40
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer’s disease progression	40
Methylome analysis of ALS patients and presymptomatic mutation carriers in blood cells	39
Enriching activities during childhood are associated with variations in functional connectivity patterns later in life	36
The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging	36
Sex and APOE genotype differences in amyloid deposition and cognitive performance along the Alzheimer’s Continuum	35
Cognitive reserve proxies are associated with age-related cognitive decline – Not age-related gait speed decline	35
Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults	35
Biomarkers of Alzheimer’s disease in Black and/or African American Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants	34
Age-related changes in midfrontal theta activity during steering control: A driving simulator study	33
The histone acylation reader ENL/AF9 regulates aging in Drosophila melanogaster	33
Genetic correlation and gene-based pleiotropy analysis for four major neurodegenerative diseases with summary statistics	31
Midlife physical activity engagement is associated with later-life brain health	31

Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex	31
Long-term olfactory enrichment promotes non-olfactory cognition, noradrenergic plasticity and remodeling of brain functional connectivity in older mice	29
WITHDRAWN: Assessment and Validation of Globodera pallida as a Novel In Vivo Model for Studying Alzheimer's Disease	28
Genotype-phenotype correlation in Tunisian patients with Amyotrophic Lateral Sclerosis	28
CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia	28
Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats	26
Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice	26
GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness	26
Loss of SST and PV positive interneurons in the ventral hippocampus results in anxiety-like behavior in 5xFAD mice	26
Evidence from theta-burst stimulation that age-related de-differentiation of the hippocampal network is functional for episodic memory	24
Effects of age on goal-dependent modulation of episodic memory retrieval	24
Validation of the pathogenic role of rare DNAJC7 variants in Chinese patients with amyotrophic lateral sclerosis	24
Multimodal hippocampal and amygdala subfield volumetry in polygenic risk for Alzheimer's disease	24
Specific microglial phagocytic phenotype and decrease of lipid oxidation in white matter areas during aging: Implications of different microenvironments	23
Assessment of LIN28A variants in Parkinson's disease in large European cohorts	22
Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline	22
Contents	22
Effects of baseline serum uric acid and apolipoprotein E4 on longitudinal cognition and cerebral metabolism	22
Age-related impairments on the touchscreen paired associates learning (PAL) task in male rats	22
Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood	22
Event-related potential evidence that very slowly presented auditory stimuli are passively processed differently in younger and older adults	22
Physical activity and amyotrophic lateral sclerosis: a Mendelian randomization study	21
Reward motivation and cognitive flexibility in tau null-mutation mice	21
Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease	21
Phasic alerting increases visual processing speed in amnestic mild cognitive impairment	21
Assessment of ANG variants in Parkinson's disease	21
Translation of the poly(GR) frame in C9ORF72-ALS/FTD is regulated by cis-elements involved in alternative splicing	20
Editorial Advisory Board	20
Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson’s disease	20
Contents Continued	20
Contents	20
Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.	20
Contents	20
Rare genetic variants correlate with better processing speed	20
TREX1 p.A129fs and p.Y305C variants in a large multi-ethnic cohort of CADASIL-like unrelated patients	19
Matrix metalloproteinases are associated with brain atrophy in cognitively unimpaired individuals	19
Machine learning approaches based on fibroblast morphometry do not predict ALS	19
Contents Continued	19
Elevated levels of tripeptidyl peptidase 1 do not ameliorate pathogenesis in a mouse model of Alzheimer disease	19
Dissociating effects of aging and genetic risk of sporadic Alzheimer’s disease on path integration	19
Weak-hyperactive hippocampal CA1 neurons in the prodromal stage of Alzheimer's disease in hybrid AppNL-G-F/NL-G-F × Thy1-GCaMP6s+/− mice suggest disrupted plasticity	19
Contents	19
The effects of age bias on neural correlates of successful and unsuccessful response inhibition in younger and older adults	19
Editorial Advisory Board	19
Genome-wide association study of executive function in a multi-ethnic cohort implicates LINC01362: Results from the northern Manhattan study	19
MAPT rs17649553 T allele is associated with better verbal memory and higher small-world properties in Parkinson’s disease	19
Editorial Advisory Board	19
Contents Continued	19
Commentary on "A framework for concepts of reserve and resilience in aging"	18
Degeneration of cholinergic white matter pathways and nucleus basalis of Meynert in individuals with objective subtle cognitive impairment	18

Paradoxical cognitive trajectories in men from earlier to later adulthood	18
Amyloid β oligomers disrupt piriform cortical output via a serotonergic pathway	18
White matter degradation near cerebral microbleeds is associated with cognitive change after mild traumatic brain injury	18
Editorial Advisory Board	18
Cerebral blood flow predicts multiple demand network activity and fluid intelligence across the adult lifespan	18
Neural regions associated with gain-loss frequency and average reward in older and younger adults	18
Phases of volume loss in patients with known frontotemporal lobar degeneration spectrum pathology	17
Contents Continued	17
Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.	17
Contents	17
Expression and proteolytic processing of the amyloid precursor protein is unaffected by the expression of the three human apolipoprotein E alleles in the brains of mice	17
Contents	17
Negative screening for 12 rare LRRK2 pathogenic variants in a cohort of Nigerians with Parkinson's disease	17
Proteomic correlates of cortical thickness in cognitively normal individuals with normal and abnormal cerebrospinal fluid beta-amyloid1-42	17
Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females	16
Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis	16
Diffusion tensor-based analysis of white matter in the healthy aging canine brain	16
Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases	16
Genetic and clinical characteristics of ALS patients with NEK1 gene variants	16
Preoperative MRI brain phenotypes are related to postoperative delirium in older individuals	16
Contents	16
Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson’s disease patients carrying the LRRK2 G2019S mutation	16
Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk	16
Sex differences in dopamine integrity and brain structure among healthy older adults: Relationships to episodic memory	16
The associations among glycemic control, heart variability, and autonomic brain function in healthy individuals: Age- and sex-related differences	16
Life-long dietary restrictions have negligible or damaging effects on late-life cognitive performance: A key role for genetics in outcomes	16
Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease	16
Improvement of mnemonic discrimination with acute light exercise is mediated by pupil-linked arousal in healthy older adults	16
Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study	16
Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons	16
Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila	16
The value of multimodal imaging with 123I-FP-CIT SPECT in differential diagnosis of dementia with Lewy bodies and Alzheimer's disease dementia	16
Association of plasma Aβ40/Aβ42 ratio and brain Aβ accumulation: testing a whole-brain PLS-VIP approach in individuals at risk of Alzheimer's disease	16
Association of homocysteine-related subcortical brain atrophy with white matter lesion volume and cognition in healthy aging	16
Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume	16
Perivascular space burden interacts with APOE-ε4 status on cognition in older adults	16
Structural brain correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study	15
Shared and oppositely regulated transcriptomic signatures in Huntington's disease and brain ischemia confirm known and unveil novel potential neuroprotective genes	15
Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort	15
Positivity effect in aging: evidence for the primacy of positive responses to emotional ambiguity	15
Contributions of hippocampal subfields and subregions to episodic memory performance in healthy cognitive aging	15
Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease	15
Longitudinal relationships between Aβ and tau to executive function and memory in cognitively normal older adults	15
Editorial Advisory Board	15
The association between hippocampal volume and memory in pathological aging is mediated by functional redundancy	15
Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression	15
Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease	15
Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice	15
Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden	15
Herpes simplex virus and Alzheimer's disease: a Mendelian randomization study	14
Cortical network modularity changes along the course of frontotemporal and Alzheimer's dementing diseases	14
Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging	14
Age-related differences in the social associative learning of trust information	14
White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia	14
Development and validation of a 13-gene signature associated with immune function for the detection of Alzheimer's disease	14
Enlarged perivascular space burden associations with arterial stiffness and cognition	14
Association of rare heterozygous PLA2G6 variants with the risk of Parkinson's disease	14
Topological changes of fast large-scale brain dynamics in mild cognitive impairment predict early memory impairment: a resting-state, source reconstructed, magnetoencephalography study	14
Racial and ethnic differences in the relationship between financial worry and white matter hyperintensities in Latinx, non-Latinx Black, and non-Latinx White older adults	14
Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment	14
Longitudinal characterization of neuroanatomical changes in the Fischer 344 rat brain during normal aging and between sexes	13
Editorial Advisory Board	13
Lower oddball event-related EEG delta and theta responses in patients with dementia due to Parkinson's and Lewy body than Alzheimer's disease	13
Relationship between regional white matter hyperintensities and alpha oscillations in older adults	13
Age-related similarities and differences in cognitive and neural processing revealed by task-related microstate analysis	13
Distant histories of mild traumatic brain injury exacerbate age-related differences in white matter properties	13
Resting EEG power spectra across middle to late life: associations with age, cognition, APOE-ɛ4 carriage, and cardiometabolic burden	13
Biophysical and synaptic properties of regular spiking interneurons in hippocampal area CA3 of aged rats	13
Expression of Concern: Wang et al., (2017) PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol. Aging, 55:99-114	13
Mutation spectrum of amyotrophic lateral sclerosis in Central South China	13
Editorial Advisory Board	13
Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis	13
Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory	13
Cerebrovascular reactivity deficits in cognitively unimpaired older adults: vasodilatory versus vasoconstrictive responses	13
Analysis of PTRHD1 common and rare variants in European patients with Parkinson's disease	13
Dose‐dependent relationship between social drinking and brain aging	13
Depthwise Cortical Iron Relates to Functional Connectivity and Fluid Cognition in Healthy Aging	13
Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: A Mendelian randomization study	13
Variable clinical phenotype in TBK1 mutations: case report of a novel mutation causing primary progressive aphasia and review of the literature	13
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[18F]fluoro-L-m-tyrosine imaging and motor performances analysis	13

Apolipoprotein E4, amyloid, and cognition in Alzheimer's and Lewy body disease	13
Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice	12
Age-dependent relationship of cardiorespiratory fitness and white matter integrity	12
Sleep/wake cycle alterations as a cause of neurodegenerative diseases: A Mendelian randomization study	12
Mutation analysis of SOD1, C9orf72, TARDBP and FUS genes in ethnically-diverse Malaysian patients with amyotrophic lateral sclerosis (ALS)	12
Dissecting the role of Amerindian genetic ancestry and the ApoE ε4 allele on Alzheimer disease in an admixed Peruvian population	12
The TgF344-AD rat: behavioral and proteomic changes associated with aging and protein expression in a transgenic rat model of Alzheimer's disease	12
Different patterns of β-amyloid deposition in patients with Alzheimer's disease according to the presence of mild parkinsonism	12
Improving brain age estimates with deep learning leads to identification of novel genetic factors associated with brain aging	12
The wide-ranging clinical and genetic features in Japanese families with valosin-containing protein proteinopathy	12
Metformin, age-related cognitive decline, and brain pathology	12
Comparison of age-related declines in behavioral auditory responses versus electrophysiological measures of amplitude modulation	12
NPC1 variants are not associated with Parkinson’s disease, REM-sleep behavior disorder or dementia with Lewy bodies in European cohorts	12
Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults	12
Fatal attraction – The role of hypoxia when alpha-synuclein gets intimate with mitochondria	12
Spectral power ratio as a measure of EEG changes in mild cognitive impairment due to Alzheimer’s disease: a case-control study	12
Selective spatial attention in lateralized multi-talker speech perception: EEG correlates and the role of age	12
Blood pressure changes impact corticospinal integrity and downstream gait and balance control	11
Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease	11
Mutation screening and burden analysis of GLT8D1 in Chinese patients with amyotrophic lateral sclerosis	11
Genome-wide association study identifies susceptibility loci of brain atrophy to NFIA and ST18 in Alzheimer's disease	11
Atypical paroxysmal slow cortical activity in healthy adults: Relationship to age and cognitive performance	11
Low-frequency and rare coding variants of NUS1 contribute to susceptibility and phenotype of Parkinson's disease	11
Sex differences in the relationship between age, performance, and BOLD signal variability during spatial context memory processing	11
Behavioral and fMRI evidence that arousal enhances bottom-up selectivity in young but not older adults	11
Genotype-phenotype correlation of Parkinson's disease with PRKN variants	11
Medial temporal lobe structure, mnemonic and perceptual discrimination in healthy older adults and those at risk for mild cognitive impairment	11
DAT1 and BDNF polymorphisms interact to predict Aβ and tau pathology	11
A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment	11
Chronic Gq activation of ventral hippocampal neurons and astrocytes differentially affects memory and behavior	11
Editorial Advisory Board	11
Associations of cerebrovascular disease and Alzheimer’s disease pathology with cognitive decline: Analysis of the National Alzheimer’s Coordinating Center Uniform Data Set	11
Association of peripheral immunity and cerebral small vessel disease in older adults without dementia: A longitudinal study	11
Tau pathology mediates age effects on medial temporal lobe structure	11
Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects	11
Bacille Calmette-Guérin attenuates vascular amyloid pathology and maximizes synaptic preservation in APP/PS1 mice following active amyloid-β immunotherapy	11
Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid β metabolism	11
Engram reactivation during memory retrieval predicts long-term memory performance in aged mice	11
KL∗VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗4 carriers	11
Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study	11
9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer’s disease neuropathology and neuroinflammation in Alzheimer’s disease-like mouse models	11
Contents	11
Nonlinear age-related differences in probabilistic learning in mice: A 5-armed bandit task study	11
Trajectories of amyloid beta accumulation – Unveiling the relationship with APOE genotype and cognitive decline	11
Age-related ultrastructural changes in the lateral cortex of the inferior colliculus	11
Increased inflammation in older high-pressure glaucoma mice	11
Tau in the brain interstitial fluid is fragmented and seeding–competent	11
Cognitive reserve, neurocognitive performance, and high-order resting-state networks in cognitively unimpaired aging	10
Brain reserve in midlife is associated with executive function changes across 12 years	10
Interstitial fluid flow decreases with age, especially after 50 years	10
White matter lesion load is associated with lower within- and greater between- network connectivity across older age	10
Association between metabolic syndrome and resting-state functional brain connectivity	10
Spontaneous prion disease in homozygous and heterozygous transgenic mouse models of T188K genetic Creutzfeldt-Jakob disease	10
Editorial Advisory Board	10
Contents Continued	10
NLX-101, a 5-HT1A receptor-biased agonist, improves pattern separation and stimulates neuroplasticity in aged rats	10
Age-related ultrastructural neurovascular changes in the female mouse cortex and hippocampus	10
Increased regional white matter hyperintensity volume in objectively-defined subtle cognitive decline and mild cognitive impairment	10
Divergent magnetic resonance imaging atrophy patterns in Alzheimer's disease and primary age-related tauopathy	10
Association of longitudinal cognitive decline with diffusion MRI in Gray Matter, Amyloid, and Tau deposition	10
Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice	10
Age-related differences in ERP correlates of value-based decision making	10
Modifiable risk factors for dementia, cognition, and plasma phosphorylated tau 181 in a large-scale cohort of Australian older adults	10
A cognitive marker for Alzheimer disease pathology in primary progressive aphasia? A validation study in the clinical setting	10
Dynamic interplay of frontoparietal cholinergic innervation and cortical reorganization in the regulation of attentional capacities in aging	10
Changes in cerebral arterial pulsatility and hippocampal volume: a transcranial doppler ultrasonography study	10
Ethnic differences in the frequency of β-amyloid deposition in cognitively normal individuals	10
Amyloid, cerebrovascular disease, and neurodegeneration biomarkers are associated with cognitive trajectories in a racially and ethnically diverse, community-based sample	10
CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system	10
Authors’ reply: Four novel optineurin mutations in patients with sporadic amyotrophic lateral sclerosis in Mainland China	10
Comparing three neuropsychological subgrouping approaches in subjective and mild cognitive impairment from a naturalistic multicenter study	10
Independent role of Alzheimer's disease genetics and C-reactive protein on cognitive ability in aging	10
Contents	10
Does functional system segregation mediate the effects of lifestyle on cognition in older adults?	10
Hippocampal and non-hippocampal correlates of physically active lifestyle and their relation to episodic memory in older adults	10
Contents Continued	9
Association of APOE-ε4 and GAP-43-related presynaptic loss with β-amyloid, tau, neurodegeneration, and cognitive decline	9
Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques	9
Temporal acuity is preserved in the auditory midbrain of aged mice	9
DNA methylation age acceleration is associated with age of onset in Chinese spinocerebellar ataxia type 3 patients	9
Association of the CD2AP locus with cognitive functioning among middle-aged individuals with a family history of Alzheimer's disease	9
Frontoparietal function and underlying structure reflect capacity for motor skill acquisition during healthy aging	9
Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults	9
Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains	9
Contents	9
Decreased investigatory head scanning during exploration in learning-impaired, aged rats	9
Lack of limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment	9
Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer’s disease pathophysiology: A longitudinal study	9
Contents	9
Contents	9
Structural volume and cortical thickness differences between males and females in cognitively normal, cognitively impaired and Alzheimer’s dementia population	9
Contents Continued	9
Age and diet modify acute microhemorrhage outcome in the mouse brain	9