Neurobiology of Aging

Papers
(The median citation count of Neurobiology of Aging is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Emerging roles of oxidative stress in brain aging and Alzheimer's disease314
Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain109
A framework for concepts of reserve and resilience in aging104
Do age-related differences in aperiodic neural activity explain differences in resting EEG alpha?68
Decreased pH in the aging brain and Alzheimer's disease61
Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease61
An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene54
Volumetric distribution of perivascular space in relation to mild cognitive impairment52
Transfer learning for predicting conversion from mild cognitive impairment to dementia of Alzheimer's type based on a three-dimensional convolutional neural network43
Sex differences in risk factors for white matter hyperintensities in non-demented older individuals42
Locus coeruleus MRI contrast is associated with cortical thickness in older adults42
Sex differences in the IntelliCage and the Morris water maze in the APP/PS1 mouse model of amyloidosis42
Aquaporin-4 polymorphisms predict amyloid burden and clinical outcome in the Alzheimer's disease spectrum41
Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics40
Aging faster: worry and rumination in late life are associated with greater brain age40
A quantitative meta-analysis of brain glutamate metabolites in aging39
Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease39
Reduced fractional anisotropy of the genu of the corpus callosum as a cerebrovascular disease marker and predictor of longitudinal cognition in MCI37
Blood and cerebrospinal fluid neurofilament light differentially detect neurodegeneration in early Alzheimer’s disease37
Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats36
GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness36
Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition36
Obesity is associated with reduced cerebral blood flow – modified by physical activity35
White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia35
Linking anatomical and physiological markers of auditory system degeneration with behavioral hearing assessments in a mouse (Mus musculus) model of age-related hearing loss34
Disappearing metabolic youthfulness in the cognitively impaired female brain34
Transient neural network dynamics in cognitive ageing33
Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease33
Causal relationships between gut metabolites and Alzheimer's disease: a bidirectional Mendelian randomization study31
Abnormal tau in amyloid PET negative individuals31
Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females31
Influence of structural and functional brain connectivity on age-related differences in fluid cognition31
Evidence of sex differences in cellular senescence30
MicroRNA predicts cognitive performance in healthy older adults29
Herpes simplex virus and Alzheimer's disease: a Mendelian randomization study29
Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults28
Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers27
Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins27
Brain-predicted age difference is associated with cognitive processing in later-life27
Age- and memory- related differences in hippocampal gray matter integrity are better captured by NODDI compared to single-tensor diffusion imaging27
ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease27
Association of enlarged perivascular spaces with Aβ and tau deposition in cognitively normal older population26
Sex differences in cognitive aging: a 4-year longitudinal study in marmosets26
Can the interplay between autophagy and apoptosis be targeted as a novel therapy for Parkinson's disease?26
Cell death and survival pathways in Alzheimer's disease: an integrative hypothesis testing approach utilizing -omic data sets26
Sleep/wake cycle alterations as a cause of neurodegenerative diseases: A Mendelian randomization study26
Different patterns of functional network reorganization across the variants of primary progressive aphasia: a graph-theoretic analysis25
Cognitive and neuroimaging profiles of older adults with dual decline in memory and gait speed25
Associations between brain amyloid accumulation and the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers24
Treatment by low-dose brain radiation therapy improves memory performances without changes of the amyloid load in the TgF344-AD rat model24
Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy24
Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation23
Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participants23
Evaluating resting-state BOLD variability in relation to biomarkers of preclinical Alzheimer's disease23
Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β–negative cognitively normal individuals23
Microstructural differences in white matter tracts across middle to late adulthood: a diffusion MRI study on 7167 UK Biobank participants23
Regional relationships between CSF VEGF levels and Alzheimer's disease brain biomarkers and cognition22
Exercise interventions do not impact brain volume change in older adults: a systematic review and meta-analysis22
Brain activity during walking in older adults: Implications for compensatory versus dysfunctional accounts22
Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations22
The age-dependent associations of white matter hyperintensities and neurofilament light in early- and late-stage Alzheimer's disease22
Prediction of brain age from routine T2-weighted spin-echo brain magnetic resonance images with a deep convolutional neural network22
TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice22
Alzheimer amyloid-β- peptide disrupts membrane localization of glucose transporter 1 in astrocytes: implications for glucose levels in brain and blood21
Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer’s disease21
Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease21
Hippocampal shape across the healthy lifespan and its relationship with cognition21
A machine learning approach to screen for preclinical Alzheimer's disease21
Complex and regional-specific changes in the morphological complexity of GFAP+ astrocytes in middle-aged mice21
Peripheral visual perception during natural overground dual-task walking in older and younger adults20
Underlying genetic variation in familial frontotemporal dementia: sequencing of 198 patients20
Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk20
Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum20
Dose‐dependent relationship between social drinking and brain aging20
Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults20
Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis20
Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging20
Characterizing the protracted neurobiological and neuroanatomical effects of paraquat in a murine model of Parkinson's disease19
Age- and gender-related differences in brain tissue microstructure revealed by multi-component T2 relaxometry19
In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies19
Reconfiguration and dedifferentiation of functional networks during cognitive control across the adult lifespan19
Increased functional connectivity supports language performance in healthy aging despite gray matter loss19
Distinct phosphorylation profiles of tau in brains of patients with different tauopathies19
Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice19
Improving brain age estimates with deep learning leads to identification of novel genetic factors associated with brain aging19
Does amnesia specifically predict Alzheimer’s pathology? A neuropathological study19
Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer’s disease19
Sex differences in Alzheimer's disease: do differences in tau explain the verbal memory gap?19
Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: A Mendelian randomization study19
Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies19
Mendelian randomization integrating GWAS and mQTL data identified novel pleiotropic DNA methylation loci for neuropathology of Alzheimer’s disease18
Education and age-related differences in cortical thickness and volume across the lifespan18
Genotype-phenotype correlation of Parkinson's disease with PRKN variants18
Positivity effect in aging: evidence for the primacy of positive responses to emotional ambiguity18
Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease18
Reduced firing rates of pyramidal cells in the frontal cortex of APP/PS1 can be restored by acute treatment with levetiracetam18
Tau in the brain interstitial fluid is fragmented and seeding–competent18
The interplay among education, brain metabolism, and cognitive impairment suggests a role of cognitive reserve in Amyotrophic Lateral Sclerosis18
The identified clinical features of Parkinson's disease in homo-, heterozygous and digenic variants of PINK118
Enlarged perivascular space burden associations with arterial stiffness and cognition18
Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study17
The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle- and old-aged individuals17
Quality of sleep predicts increased frontoparietal network connectivity in patients with mild cognitive impairment17
Propagation patterns in motor neuron diseases: Individual and phenotype-associated disease-burden trajectories across the UMN-LMN spectrum of MNDs17
The association between inadequate sleep and accelerated brain ageing17
Stabilization of microtubules improves cognitive functions and axonal transport of mitochondria in Alzheimer's disease model mice17
Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson’s disease patients carrying the LRRK2 G2019S mutation17
Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters17
Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome17
Functional connectivity differences in Alzheimer's disease and amnestic mild cognitive impairment associated with AT(N) classification and anosognosia17
Enriching activities during childhood are associated with variations in functional connectivity patterns later in life17
DKI enhances the sensitivity and interpretability of age-related DTI patterns in the white matter of UK biobank participants16
Multimodal hippocampal and amygdala subfield volumetry in polygenic risk for Alzheimer's disease16
Progression of neuroimaging markers of cerebral small vessel disease in older adults: A 6-year follow-up study16
Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease16
Brain tissue properties link cardio-vascular risk factors, mood and cognitive performance in the CoLaus|PsyCoLaus epidemiological cohort16
Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice16
Genetic epidemiology of familial ALS in Brazil16
EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel16
Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers16
Genetic investigation of amyotrophic lateral sclerosis patients in south Italy: a two-decade analysis16
Predicting time-to-conversion for dementia of Alzheimer's type using multi-modal deep survival analysis16
Scene memory and hippocampal volume in middle-aged women with early hormone loss16
Neurogranin as biomarker in CSF is non-specific to Alzheimer's disease dementia16
Global brain volume and N-acetyl-aspartate decline over seven decades of normal aging16
Evaluation of early microstructural changes in the R6/1 mouse model of Huntington's disease by ultra-high field diffusion MR imaging16
Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts16
Validation of neuroimaging-based brain age gap as a mediator between modifiable risk factors and cognition16
Mutation spectrum of amyotrophic lateral sclerosis in Central South China16
Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson’s disease16
A neural signature of regularity in sound is reduced in older adults16
Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer’s disease16
Association and interaction of TOMM40 and PVRL2 with plasma amyloid-β and Alzheimer's disease among Chinese older adults: a population-based study16
Suppression of the kinase for elongation factor 2 alleviates mGluR-LTD impairments in a mouse model of Alzheimer’s disease16
Age-related central gain with degraded neural synchrony in the auditory brainstem of mice and humans16
Age-related differences in resting-state and task-based network characteristics and cognition: a lifespan sample16
Effects of exercise training on neuromuscular junctions and their active zones in young and aged muscles16
Long-term maintenance of multitasking abilities following video game training in older adults15
PLA2G6 variants associated with the number of affected alleles in Parkinson’s disease in Japan15
Fatal attraction – The role of hypoxia when alpha-synuclein gets intimate with mitochondria15
LTP-like plasticity is impaired in amyloid-positive amnestic MCI but independent of PET-amyloid burden15
Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography15
Reduced modulation of BOLD variability as a function of cognitive load in healthy aging15
Age-related differences in cerebral blood flow and cortical thickness with an application to age prediction15
Brain energy metabolism and neurodegeneration: hints from CSF lactate levels in dementias15
Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease15
Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment15
Both male and female APPswe/PSEN1dE9 mice are impaired in spatial memory and cognitive flexibility at 9 months of age15
Changes in the intracellular microenvironment in the aging human brain15
Orthogonal moment diffusion tensor decomposition reveals age-related degeneration patterns in complex fiber architecture15
Increased intrinsic excitability and decreased synaptic inhibition in aged somatosensory cortex pyramidal neurons15
Neuropathology of depression in non-demented older adults: A large postmortem study of 741 individuals15
Engram reactivation during memory retrieval predicts long-term memory performance in aged mice15
Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume15
Molecular imaging of beta-amyloid deposition in late-life depression15
Higher motor cortical excitability linked to greater cognitive dysfunction in Alzheimer's disease: results from two independent cohorts15
Mutation analysis of TMEM family members for early-onset Parkinson’s disease in Chinese population15
Age affects white matter microstructure and episodic memory across the older adult lifespan14
Healthy dietary intake moderates the effects of age on brain iron concentration and working memory performance14
Impaired error awareness in healthy older adults: an age group comparison study14
Associations of increased interstitial fluid with vascular and neurodegenerative abnormalities in a memory clinic sample14
Variable clinical phenotype in TBK1 mutations: case report of a novel mutation causing primary progressive aphasia and review of the literature14
Loss of SST and PV positive interneurons in the ventral hippocampus results in anxiety-like behavior in 5xFAD mice14
Serum and cerebrospinal fluid Neutrophil gelatinase-associated lipocalin (NGAL) levels as biomarkers for the conversion from mild cognitive impairment to Alzheimer's disease dementia14
Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age14
Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction14
Pain processing in older adults with dementia-related cognitive impairment is associated with frontal neurodegeneration14
A subtype of cerebrovascular pericytes is associated with blood-brain barrier disruption that develops during normal aging and simian immunodeficiency virus infection14
Association between telomere length and Parkinson's disease: a Mendelian randomization study14
Association of glial tau pathology and LATE-NC in the ageing brain14
Multimodal in vivo and postmortem assessments of tau in Lewy body disorders14
Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis14
The association between hippocampal volume and memory in pathological aging is mediated by functional redundancy14
Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis13
The role of anterior prefrontal cortex in prospective memory: an exploratory FDG-PET study in early Alzheimer's disease13
Cognitive reserve, neurocognitive performance, and high-order resting-state networks in cognitively unimpaired aging13
Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis13
Quantitative EEG and cholinergic basal forebrain atrophy in Parkinson's disease and mild cognitive impairment13
APOE, TOMM40, and sex interactions on neural network connectivity13
Spatiotemporal relationship between subthreshold amyloid accumulation and aerobic glycolysis in the human brain13
Capillary dysfunction correlates with cortical amyloid load in early Alzheimer's disease13
C-reactive protein and risk of Alzheimer's disease13
Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease13
The value of multimodal imaging with 123I-FP-CIT SPECT in differential diagnosis of dementia with Lewy bodies and Alzheimer's disease dementia13
Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease13
Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging13
Differential associations of age and Alzheimer's disease with sleep and rest-activity rhythms across the adult lifespan13
Generalization of memory-related brain function in asymptomatic older women with a family history of late onset Alzheimer's Disease: Results from the PREVENT-AD Cohort13
DNA methylation in the TNF-alpha gene decreases along with aging among delirium inpatients13
Adult lifespan maturation and degeneration patterns in gray and white matter: A mean apparent propagator (MAP) MRI study13
Aging induces abnormal accumulation of Aβ in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain13
A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment13
Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases13
LRRK2 p.M1646T is associated with glucocerebrosidase activity and with Parkinson's disease13
Biological correlates of elevated soluble TREM2 in cerebrospinal fluid13
Elevated norepinephrine metabolism is linked to cortical thickness in the context of Alzheimer's disease pathology13
1H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults13
Early low-dose ghrelin intervention via miniosmotic pumps could protect against the progressive dopaminergic neuron loss in Parkinson's disease mice13
Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population12
Implications for microglial sex differences in tau-related neurodegenerative diseases12
Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function12
Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer's disease12
Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice12
Learning in anticipation of reward and punishment: perspectives across the human lifespan12
Age-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimer's disease12
Metabolic syndrome and its components in relation to in vivo brain amyloid and neurodegeneration in late middle age12
Increased regional white matter hyperintensity volume in objectively-defined subtle cognitive decline and mild cognitive impairment12
Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice12
Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes12
Cognitively normal APOE ε4 carriers have specific elevation of CSF SNAP-2512
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling12
Dopaminergic modulation of working memory and cognitive flexibility in a zebrafish model of aging-related cognitive decline12
Female-specific risk of Alzheimer's disease is associated with tau phosphorylation processes: A transcriptome-wide interaction analysis12
TSPO deficiency accelerates amyloid pathology and neuroinflammation by impairing microglial phagocytosis12
Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice12
The association between personality and plasma biomarkers of astrogliosis and neuronal injury12
Cognitive reserve proxies, Alzheimer pathologies, and cognition12
Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin.11
Association of liver disease with brain volume loss, cognitive decline, and plasma neurodegenerative disease biomarkers11
The relationship of functional hippocampal activity, amyloid deposition, and longitudinal memory decline to memory complaints in cognitively healthy older adults11
Shared genetic links between amyotrophic lateral sclerosis and obesity-related traits: a genome-wide association study11
Premature termination codon mutations in ABCA7 contribute to Alzheimer's disease risk in Belgian patients11
Amyloid precursor protein intracellular domain-dependent regulation of FOXO3a inhibits adult hippocampal neurogenesis11
Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults11
Altered network stability in progressive supranuclear palsy11
Resting EEG power spectra across middle to late life: associations with age, cognition, APOE-ɛ4 carriage, and cardiometabolic burden11
Methylome analysis of ALS patients and presymptomatic mutation carriers in blood cells11
CSF peptides from VGF and other markers enhance prediction of MCI to AD progression using the ATN framework11
Regional age-related atrophy after screening for preclinical alzheimer disease11
Increased functional homotopy of the prefrontal cortex is associated with corpus callosum degeneration and working memory decline11
Age-related decline in cochlear ribbon synapses and its relation to different metrics of auditory-nerve activity11
Glial profiling of human tauopathy brain demonstrates enrichment of astrocytic transcripts in tau-related frontotemporal degeneration11
GABAA receptor agonist muscimol rescues inhibitory microcircuit defects in the olfactory bulb and improves olfactory function in APP/PS1 transgenic mice11
Chronic Gq activation of ventral hippocampal neurons and astrocytes differentially affects memory and behavior11
Age-related ultrastructural neurovascular changes in the female mouse cortex and hippocampus11
Alpha desynchronization during Stroop test unmasks cognitively healthy individuals with abnormal CSF Amyloid/Tau11
Association of homocysteine-related subcortical brain atrophy with white matter lesion volume and cognition in healthy aging11
Novel TARDBP missense mutation caused familial amyotrophic lateral sclerosis with frontotemporal dementia and parkinsonism11
Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses11
Cognitively stimulating environments and cognitive reserve: the case of personal social networks11
Linguistic profiles, brain metabolic patterns and rates of amyloid-β biomarker positivity in patients with mixed primary progressive aphasia11
Altered event-related potentials and theta oscillations index auditory working memory deficits in healthy aging11
Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study11
Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease11
Association between metabolic syndrome and resting-state functional brain connectivity11
KL∗VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗4 carriers11
Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease11
Presenilin 1 mutation likely contributes to U1 small nuclear RNA dysregulation and Alzheimer's disease–like symptoms11
Translation of the poly(GR) frame in C9ORF72-ALS/FTD is regulated by cis-elements involved in alternative splicing10
Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.10
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