Neurobiology of Aging

Article	Citations
Machine learning approaches based on fibroblast morphometry do not predict ALS	364
Neuronal TrkB supports adult cortical oligodendrogenesis in the brains of older adult mice	172
Chronic BMAA exposure combined with TDP-43 mutation elicits motor neuron dysfunction phenotypes in mice	69
Topological changes of fast large-scale brain dynamics in mild cognitive impairment predict early memory impairment: a resting-state, source reconstructed, magnetoencephalography study	49
Editorial Advisory Board	49
Gene age gap estimate (GAGE) for major depressive disorder: A penalized biological age model using gene expression	43
Editorial Advisory Board	40
The genetic overlap between Alzheimer’s disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson’s disease	37
Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions	34
The role of cognitive-motor interaction in landmark reliance and navigational deficits in older adults	34
Contents	32
Trajectories of amyloid beta accumulation – Unveiling the relationship with APOE genotype and cognitive decline	32
Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila	32
Low-moderate dose whole-brain γ-ray irradiation modulates the expressions of glial fibrillary acidic protein and intercellular adhesion molecule-1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine–i	32
Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study	32
A cognitive marker for Alzheimer disease pathology in primary progressive aphasia? A validation study in the clinical setting	30
Contents	30
Editorial Advisory Board	30
Contents	30
Comparison of age-related declines in behavioral auditory responses versus electrophysiological measures of amplitude modulation	29
Medial temporal lobe structure, mnemonic and perceptual discrimination in healthy older adults and those at risk for mild cognitive impairment	29
Recollection-related fMRI effects in entorhinal cortex predict longitudinal memory change in healthy older adults	29
Associations of cerebrovascular disease and Alzheimer’s disease pathology with cognitive decline: Analysis of the National Alzheimer’s Coordinating Center Uniform Data Set	29
Spontaneous prion disease in homozygous and heterozygous transgenic mouse models of T188K genetic Creutzfeldt-Jakob disease	29
Isoform-specific effects of neuronal inhibition of AMPK catalytic subunit on LTD impairments in a mouse model of Alzheimer’s disease	28

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with abnormalities in white matter structural integrity and connectivity: An ex-vivo diffusion MRI	28
Blood pressure changes impact corticospinal integrity and downstream gait and balance control	28
Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults	28
Effector-dependent decline in strength and subcortical motor excitability with aging	27
Identification of circular RNAs associated with ageing of the dorsolateral prefrontal cortex across the adult lifespan	27
Age-related differences in ERP correlates of value-based decision making	26
Divergent magnetic resonance imaging atrophy patterns in Alzheimer's disease and primary age-related tauopathy	25
CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system	25
Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults	25
Acute corticospinal and reticulospinal responses to strength training in ageing	25
Epigenetic age is associated with regional brain aging along the sensorimotor-to-association axis of cortical organization	25
Do age-related differences in aperiodic neural activity explain differences in resting EEG alpha?	25
Exploring the domain specificity and the neural correlates of memory unawareness in Alzheimer's disease	24
Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with lower R2 relaxation rate: an ex-vivo MRI and pathology investigation	24
Editorial Advisory Board	24
Increased neural differentiation after a single session of aerobic exercise in older adults	24
Editorial: Guide for authors at Neurobiology of Aging	24
Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra	24
ANXA1 mutation analysis in Italian patients with early onset PD	23
White matter hyperintensities in dementia with lewy bodies and posterior cortical atrophy	23
Resting-state functional connectivity abnormalities in subjective cognitive decline: A 7T MRI study	22
Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants	22
Contents	22
Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon	22
Dynamics and role of covalently-closed circular RNAs in Alzheimer's disease: A review of experimental and bioinformatics studies	22
Amyloid-associated cognitive trajectories in aging dogs mirror early changes in humans	22
Voice biomarkers as indicators of cognitive changes in middle and later adulthood	22
High-fat diet and aging-associated memory impairments persist in the absence of microglia in female rats	22
Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer’s disease	22
Zebrafish optomotor response to second-order motion illustrates that age-related changes in motion detection depend on the activated motion system	22
Editorial Advisory Board	21
Relationship between inner hair cell synaptopathy and outer hair cell loss in two mouse models of accelerated age-related hearing loss	21
Mediterranean diet is associated with lower white matter lesion volume in Mediterranean cities and lower cerebrospinal fluid Aβ42 in non-Mediterranean cities in the EPAD LCS cohort	21
Reduced structural connectivity of the medial temporal lobe including the perforant path is associated with aging and verbal memory impairment	21
Adult lifespan maturation and degeneration patterns in gray and white matter: A mean apparent propagator (MAP) MRI study	21
Contents	21
Identifying a proteomics signature of cognitive impairment and dementia in blood and cerebrospinal fluid through a mediation analysis framework	21
Age-related differences in memory encoding as a function of pupillary dynamics	21
Apolipoprotein E and Alzheimer’s disease pathology in African American older adults	21
Alpha band activity mediates age-related effects on three distinct aspects of working memory dynamics	20
Neuropsychology of cognitive aging in rhesus monkeys	20
Contents	20
Hearing loss and its relation to longitudinal changes in white matter microstructure in older adults: The Rotterdam Study	20
Diagnostic performance of plasma pTau217/Aβ42 ratio and a three-zone threshold model for Alzheimer’s disease	20
The moderating effect of diet on the relationship between depressive symptoms and Alzheimer’s disease-related blood-based biomarkers	20
The (hyper)excitable brain: what can a ubiquitous TMS measure reveal about cognitive aging?	20
Excess iron may accelerate amyloid beta accumulation in the brains of older mice	20
Optimized atlas for early tau-PET staging via native space segmentations	20
Single-neuron whole genome sequencing identifies increased somatic mutation burden in Alzheimer's disease related genes	20
Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers	20

Patterns of amyloid accumulation in amyloid-negative cases	19
Contents	19
Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores	19
Editorial Advisory Board	19
Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults	19
Age differences in the neural processing of semantics, within and beyond the core semantic network	19
Contents	19
Age-related differences in how the shape of alpha and beta oscillations change during reaction time tasks	18
Editorial Advisory Board	18
Modeling functional loss in Alzheimer’s Disease through cognitive reserve and cognitive state: A panel data longitudinal study	18
Ensemble-specific deficit in neuronal intrinsic excitability in aged mice	18
Electrophysiological alterations during action semantic processing in Parkinson’s disease	18
Editorial Advisory Board	18
White matter hyperintensity regression: Fact or artifact?	18
White matter hyperintensities contribute to early cortical thinning in addition to tau in aging	18
Age-related ultrastructural differences in the dorsal cortex of the inferior colliculus in the fischer brown Norway rat	18
Biologic that disrupts PDE11A4 homodimerization in hippocampus CA1 reverses age-related cognitive decline of social memories in mice	18
APOE4 homozygote females are resistant to the beneficial effects of 17β-estradiol on memory and CA1 dendritic spine density in the EFAD mouse model of Alzheimer's disease	18
Persistent blood-brain barrier dysregulation in patients with obstructive sleep apnea following long-term continuous positive airway pressure treatment	17
Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts	17
Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease	17
Biological correlates of elevated soluble TREM2 in cerebrospinal fluid	17
Apraxic deficits in Alzheimer’s disease are associated with altered dynamic connectivity in praxis-related networks	17
Resting-state EEG aperiodic exponent moderates the association between age and memory performance in older adults	17
Physical activity levels and brain structure in middle-aged and older adults: a bidirectional longitudinal population-based study	17
The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study	17
Integrating plasma, MRI, and cognitive biomarkers for personalized prediction of decline across cognitive domains	17
Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis	17
Corrigendum to: A clinical, molecular genetics and pathological study of a FTDP-17 family with a heterozygous splicing variant c.823–10 G>T at the intron 9/exon 10 of the MAPT gene	17
Brain oscillatory processes related to sequence memory in healthy older adults	17
Longitudinal non-linear changes in the microstructure of the hippocampal subfields in older adults	16
CSF peptides from VGF and other markers enhance prediction of MCI to AD progression using the ATN framework	16
Association of an in vivo classifier for ARTerioloSclerosis (ARTS) with cortical thickness and cognition in older adults	16
Age differences in the neural correlates of recollection: transient versus sustained fMRI effects	16
Editorial Advisory Board	16
Associations of brain morphology with cortical proteins of cognitive resilience	16
Depressive symptoms are associated with reduced positivity preferences in episodic memory in aging	16
Mutation analysis of the ECE1 gene in late-onset Alzheimer’s disease	16
Blood-brain barrier water permeability across the adult lifespan: A multi-echo ASL study	15
Free water-corrected fractional anisotropy of the fornix and parahippocampal cingulum predicts longitudinal memory change in cognitively healthy older adults	15
Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease	15
Contents Continued	15
Commentary on "A framework for concepts of reserve and resilience in aging"	15
Neuropathologic correlates of cerebral microbleeds in community-based older adults	15
Lower oddball event-related EEG delta and theta responses in patients with dementia due to Parkinson's and Lewy body than Alzheimer's disease	15
The effects of age bias on neural correlates of successful and unsuccessful response inhibition in younger and older adults	15
Contents Continued	15
Predicting time-to-conversion for dementia of Alzheimer's type using multi-modal deep survival analysis	15
Editorial Advisory Board	15
Editorial Advisory Board	15
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Contents	14
Cognitive reserve proxies are associated with age-related cognitive decline – Not age-related gait speed decline	14
Matrix metalloproteinases are associated with brain atrophy in cognitively unimpaired individuals	14
Associations of epigenetic age acceleration with motor impairment: Evidence from the Parkinson's Progression Markers Initiative cohort	14
Genotype-phenotype correlation in Tunisian patients with Amyotrophic Lateral Sclerosis	14
Excitatory and inhibitory neurotransmitter alterations with advancing age and injury in the mouse retina	14
Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability	14
Repeated brain MRI utility in identifying neurodegenerative disorders at the pre-dementia stage	14
Editorial Advisory Board	14
Loss of SST and PV positive interneurons in the ventral hippocampus results in anxiety-like behavior in 5xFAD mice	14
Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice	14
Brain structural indicators of β-amyloid neuropathology	13
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Contents Continued	13
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer’s disease progression	13
Brain reserve in midlife is associated with executive function changes across 12 years	13
White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer’s disease continuum	13
Gene-based burden analysis of damaging private variants in PRKN, PARK7 and PINK1 in Parkinson's disease cohorts of European descent	13
Contents Continued	13
CSF phosphorylated tau as an indicator of subsequent tau accumulation	13
Lower locus coeruleus integrity is associated with diminished practice effects in clinically unimpaired older individuals	13
The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer's disease mouse model	13
Age-related similarities and differences in cognitive and neural processing revealed by task-related microstate analysis	13
The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study	13
Hippocampal 1H-MR spectroscopy metabolites are linked to CSF tau pathology in cognitively unimpaired older adults along the Alzheimer’s continuum	13
Contents	13
NPC1 variants are not associated with Parkinson’s disease, REM-sleep behavior disorder or dementia with Lewy bodies in European cohorts	13
Re-analysis of the Hungarian amyotrophic lateral sclerosis population and evaluation of novel ALS genetic risk variants	13
Genetic and clinical characteristics of ALS patients with NEK1 gene variants	13

Study of Alzheimer's disease- and frontotemporal dementia-associated genes in the Cretan Aging Cohort	13
Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes	13
Editorial Advisory Board	12
Auditory robustness and resilience in the aging auditory system of the desert locust	12
Combining cannabidiol and delta-9-tetrahydrocannabinol at a 50:3 ratio – a new therapeutic strategy for APPSwe/PS1ΔE9 transgenic mice?	12
Aging induces cell loss and a decline in phagosome processing in the mouse retinal pigment epithelium	12
Predicting future cognitive decline from non-brain and multimodal brain imaging data in healthy and pathological aging	12
Impact of thyroid hormone perturbations in adult mice: brain weight and blood vessel changes, gene expression variation, and neurobehavioral outcomes	12
Corrigendum to “Dissemination in time and space in presymptomatic granulin mutation carriers: A spatial chronnectome study” [Neurobiology of Aging Volume 108, December 2021, Pages 155–167]	12
Relation of MRI visible perivascular spaces with global and regional brain structural connectivity measures: The Framingham Heart Study (FHS)	12
Editorial Advisory Board	12
Moderating effects of cognitive reserve on the relationship between brain structure and cognitive abilities in middle-aged and older adults	12
Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome	12
Editorial Advisory Board	12
Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans	12
Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice	12
Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults	12
Contents	12
Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden	12
Myelin, aging, and physical exercise	11
Editorial Advisory Board	11
Proteomic polygenic risk scores of age-related plasma protein levels reveal a role for Metalloproteinase inhibitor 2 (TIMP2) in cognitive performance	11
Altered theta distribution and coherence during set-shifting in older age	11
Identification and functional characterization of novel variants of MAPT and GRN in Chinese patients with frontotemporal dementia	11
Effects of age on the strategic control of recollected content as reflected by modulation of neural correlates of scene retrieval	11
Corrigendum to “Longitudinal characterization of neuroanatomical changes in the Fischer 344 rat brain during normal aging and between sexes [neurobiology of aging. 109 (2022) 216–228]”	11
Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients	11
Contents Continued	11
Heterogenous response to aging of astrocytes in murine Substantia Nigra pars compacta and pars reticulata	11
Extracellular matrix proteoglycans support aged hippocampus networks: a potential cellular-level mechanism of brain reserve	11
Neural atrophy produced by AAV tau injections into hippocampus and anterior cortex of middle-aged mice	11
Aging of gray matter microstructure: A brain-wide characterization of age group differences using NODDI	11
Contents Continued	11
Longitudinal associations of absolute versus relative moderate-to-vigorous physical activity with brain microstructural decline in aging	11
Racial differences in white matter hyperintensity burden in older adults	11
Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer’s disease mild cognitive impairment progression at a 6-month follow-up	11
Exploring graded profiles of hippocampal atrophy along the anterior-posterior axis in semantic dementia and Alzheimer’s disease	11
Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer’s Disease in individuals of African Ancestry	10
Editorial Advisory Board	10
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Cognitive reserve moderates the association between cerebral blood flow and language performance in older adults with mild cognitive impairment	10
Alzheimer’s disease cerebrospinal fluid biomarker levels and APOE genetic status are associated with hippocampal-cerebellar functional connectivity	10
Fiber-specific age-related differences in the white matter of healthy adults uncovered by fixel-based analysis	10
Editorial Advisory Board	10
Beyond group classification: Probabilistic differential diagnosis of frontotemporal dementia and Alzheimer’s disease with MRI and CSF biomarkers	10
Comparing neural activity during autobiographical memory retrieval between younger and older adults: An ALE meta-analysis	10
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Nicotine reduces age-related changes in cortical neural oscillations without affecting auditory brainstem responses	10
Association of plasma glial fibrillary acidic protein and APOE-ε4 with Alzheimer’s disease	10
Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed	10
Two-year changes in hippocampal subfield volumes are age-dependent across the lifespan	10
Explaining tip-of-the-tongue experiences in older adults: The role of brain-based and cardiorespiratory fitness factors	10
Multimodal investigation of neuropathology and neurometabolites in mild cognitive impairment and late-life depression with 11C-PiB beta-amyloid PET and 7T magnetic resonance spectroscopy	10
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Neuronal vulnerability to brain aging and neurodegeneration in cognitively impaired marmoset monkeys (Callithrix jacchus)	10
EEG slow waves and cognitive decline in Isolated Rapid Eye Movements Behavior Disorder: A multicenter longitudinal study	10
Brain connectivity in frailty: Insights from The Irish Longitudinal Study on Ageing (TILDA)	10
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Editorial Advisory Board	10
Neural network mechanisms of emotional dysregulation in cerebral small vessel disease	10
Neuronal hyperexcitability in the Tg2576 mouse model of Alzheimer's disease – the influence of sleep and noradrenergic transmission	10
Serum HDL-cholesterol is associated with the clinical-biological profile of early-stage Parkinson’s disease patients independently of APOE	10
Decomposing neurophysiological underpinnings of age-related decline in visual working memory	9
Aging modulates large-scale neural network interactions during speech comprehension	9
Early treatment with an M1 and sigma-1 receptor agonist prevents cognitive decline in a transgenic rat model displaying Alzheimer-like amyloid pathology	9
Alzheimer’s disease cortical morphological phenotypes are associated with TOMM40′523-APOE haplotypes	9
A novel 14mer peptide, T14, is associated with age-dependent behaviour in female mice	9
Common and rare variants of EGF increase the genetic risk of Alzheimer's disease as revealed by targeted sequencing of growth factors in Han Chinese	9
Concurrent associations between visit-to-visit changes in actigraphy-based physical activity and cognitive aging in older adults	9
Variants in the Niemann-pick type C genes are not associated with Alzheimer's disease: a large case-control study in the Chinese population	9
White matter hyperintensity shape is associated with cognitive functioning – the SMART-MR study	9
Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging	9
An integrated genome and phenome-wide association study approach to understanding Alzheimer's disease predisposition	9
Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer's disease	9
Editorial Advisory Board	9
Body fat and components of sarcopenia relate to inflammation, brain volume, and neurometabolism in older adults	9
Sex differences in plasma lipid profiles of accelerated brain aging	9
Tau association with synaptic mitochondria coincides with energetic dysfunction and excitatory synapse loss in the P301S tauopathy mouse model	9
Inverse correlation between Alzheimer’s disease and cancer from the perspective of hypoxia	9
Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity	9
Contributions of mouse genetic strain background to age-related phenotypes in physically active HET3 mice	9
Longitudinal assessment of cognitive function in the APPswe/PS1dE9 mouse model of Alzheimer’s-related beta-amyloidosis	9
Sleep quality and sleep duration predict brain microstructure among community-dwelling older adults	9
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The association between posterior resting-state EEG alpha rhythms and functional MRI connectivity in older adults with subjective memory complaint	9
Editorial Advisory Board	9
Genetic evidence that the causal association of educational attainment with reduced risk of Alzheimer's disease is driven by intelligence	9
Editorial Advisory Board	8
Sex differences in the relationship between age, performance, and BOLD signal variability during spatial context memory processing	8
DAT1 and BDNF polymorphisms interact to predict Aβ and tau pathology	8
Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid β metabolism	8
Rare exonic variant affects GRN splicing and contributes to frontotemporal lobar degeneration	8
Corrigendum to “Elevation of cytoskeletal protein breakdown in aged Wistar rat brain” [Neurobiol. Aging 27 (2006) 624–632]	8
Hypothalamic imaging in Alzheimer’s disease and Lewy body dementia: A systematic review and meta-analysis	8