OOIR: Observatory of International Research

Papers

(The TQCC of Peptides is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
The first structure-activity relationship study of oxytocin as a positive allosteric modulator for the µ opioid receptor	101
Editorial Board	59
Editorial Board	48
PCP consensus protein/peptide alphavirus antigens stimulate broad spectrum neutralizing antibodies	47
Corrigendum to “Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis” [Peptides 182 (2024) 171323]	45
Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats	45
Transcardiac gradients of pro-cholecystokinin, cholecystokinin, and gastrin in patients with and without heart failure with reduced ejection fraction	41
Serum alanine transaminase is predictive of fasting and postprandial insulin and glucagon concentrations in type 2 diabetes	34
The present and future of synthetic orexin receptor agonists	34
Desacyl-ghrelin, not just an inactive form of ghrelin? A review of current knowledge on the biological actions of desacyl-ghrelin	33
Gut hormone analogues and skeletal health in diabetes and obesity: Evidence from preclinical models	32
KNDy neurons as the GnRH pulse generator: Recent studies in ruminants	32
Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity	30
The antimicrobial peptide Abaecin alleviates colitis in mice by regulating inflammatory signaling pathways and intestinal microbial composition	29
The impact of multifunctional enkephalin analogs and morphine on the protein changes in crude membrane fractions isolated from the rat brain cortex and hippocampus	27
Nesfatin-1 regulates steroidogenesis in mouse Leydig cells	27
Studies on the in vitro mechanism and in vivo therapeutic effect of the antimicrobial peptide ACP5 against Trichophyton mentagrophytes	26
Asprosin-mediated regulation of ovarian functions in mice: An age-dependent study	26
Editorial Board	25
Editorial Board	25
Peptides and primate personality: Central and peripheral oxytocin and vasopressin levels and social behavior in two baboon species (Papio hamadryas and Papio anubis)	24
Editorial Board	24
The protective role of Nesfatin-1 against TNF-α-induced ferroptosis in chondrocytes: Implications for osteoarthritis therapy	23
P1642-1, a novel pancreatic polypeptide analogue, ameliorates cognitive impairment in 5 ×FAD mice and is associated with enhanced PINK1/Parkin-related mitophagy	20
VR-10 polypeptide interacts with CD36 to induce cell apoptosis and autophagy in choroid-retinal endothelial cells: Identification of VR-10 as putative novel therapeutic agent for choroid neovasculariz	20

A chimeric natriuretic peptide (Ev-NP) inhibits isoproterenol (ISO)-induced hypertrophic growth in in vivo and in vitro models by enhancing cGMP and its downstream signaling targets: In silico docking	20
Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development	20
Impact of galanin receptors 2 and 3 double-knockout on neuroinflammation and functional recovery following traumatic brain injury	19
Suppression of B-type natriuretic peptide gene expression in cardiomyocytes under anoxic conditions	19
Synthesis, conformation and cytotoxic activity of short hybrid peptides containing conformationally constrained 1-(aminomethyl)cyclohexanecarboxylic acid and gabapentin	18
Endogenous opiates and behavior: 2024	18
Modulatory role of neuropeptide FF system in macrophages	18
Dulaglutide accelerates diabetic wound healing by suppressing Nrf2-dependent ferroptosis in diabetic mice	18
Lasso peptides realm: Insights and applications	17
Glucagon-like peptide-1 receptor promotes osteoblast differentiation of dental pulp stem cells and bone formation in a zebrafish scale regeneration model	16
GIP-derived GIP receptor antagonists – a review of their role in GIP receptor pharmacology	16
Dysfunction of the renin-angiotensin-aldosterone system in human septic shock	16
Editorial Board	15
A novel endomorphin-2/salmon calcitonin hybrid peptide with enhancing anti-allodynic and anti-anxiety effects	15
Allatotropin (AT) related peptides L-ATRP and D2-ATRP diastereomers activate an endogenous receptor and suppress heart rate in the Pacific abalone Haliotis discus hannai	15
Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells	15
Erythropoietin attenuates lead-induced spatial memory deficits and anxiety-like behavior by suppressing hippocampal oxidative stress, cell death inhibition, and inflammation reduction	15
Influence of the angiotensin-(1−7) on the vascular effects of the endothelin-1 in normotensive and hypertensive rats	15
JHP-7 (QLLEELKR), a heptapeptide derived from Jinhua ham, may ameliorate intrauterine adhesion (IUA) via inhibiting inflammatory response and apoptosis	14
Recombinant production of isotope-labeled human α-defensin 5 via calmodulin fusion and insights into its expression enhancement	14
Glucagon and energy expenditure; Revisiting amino acid metabolism and implications for weight loss therapy	14
The intricate relationship between circadian rhythms and gastrointestinal peptides in obesity	14
The role of leptin and ghrelin in the regulation of appetite in obesity	14
Endogenous opiates and behavior: 2023	14
Significance of D- tryptophan in Contryphan-Ar1131 Conus peptide: Oxidative folding, trypsin binding, and photostabilization activity	14
Editorial Board	13
Targeting the GLP-2 receptor in the management of obesity	13
The T-1 conotoxin μ-SrVA from the worm hunting marine snail Conus spurius preferentially blocks the human NaV1.5 channel	13
Venomous gland transcriptome and venom proteomic analysis of the scorpion Androctonus amoreuxi reveal new peptides with anti-SARS-CoV-2 activity	13
Rational antimicrobial peptide engineering through amino acid scanning and targeted point mutations	13
Reduced plasma cortistatin is related to clinical parameters in patients with essential hypertension	13
Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol	13
Effect of pregnancy on the expression of nutrient-sensors and satiety hormones in mice	12
Glucagon-based therapy for people with diabetes and obesity: What is the sweet spot?	12
Estrogens impair hypophagia and hypothalamic cell activation induced by vasoactive intestinal peptide, but not by pituitary adenylate cyclase-activating polypeptide	12
PACAP inhibits sepsis-associated acute lung injury by inhibiting the Sp1/AQP1 pathway	12
The effects of corticotropin-releasing factor (CRF) and urocortins on the noradrenaline (NA) released from the locus coeruleus (LC)	12
Investigation of irisin's role in pubertal onset physiology in female rats	12
Corrigendum to “Liraglutide inhibited AGEs induced coronary smooth muscle cell phenotypic transition through inhibiting the NF-κB signal pathway” [Peptides 112 (2019) 125–132]	11
Egg white-derived peptide KPHAEVVLR promotes wound healing in rat palatal mucosa via PI3K/AKT/mTOR pathway	11
Body weight modulates the impact of oxytocin on chronic cold-immobilization stress response	11
The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats	11
Spexin expression in the human bile duct and perihilar cholangiocarcinoma	11
Role of brain NUCB2/nesfatin-1 in stress and stress-related gastrointestinal disorders	11
Editorial: Special issue novel aspects of islet peptides	11
Tirzepatide improves angiogenesis after diabetic hindlimb ischemia through Akt/eNOS and ERK1/2 pathways	11
Liraglutide suppresses ferroptosis by upregulation NRF2 in type 2 diabetic cardiomyopathy	11
Neuropeptides affecting social behavior in mammals: Oxytocin	10
Maximizing cost savings in heart failure management: The economic value of natriuretic peptide testing	10
Synergistic interaction between DAMGO-NH2 and NOP01 in peripherally acting antinociception in two mouse models of formalin pain	10

Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats	10
Editorial Board	10
Activity dependent neuroprotective protein mediates the protective effects against VEGF-induced corneal barrier disruption in diabetes	10
Angiotensin-(1−7) attenuates the negative inotropic response to acetylcholine in the heart	9
Role of sexually dimorphic oxytocin receptor-expressing neurons in the anteroventral periventricular nucleus on maternal behavior	9
Alamandine attenuates oxidative stress in the right carotid following transverse aortic constriction in mice	9
Characterization of rice endosperm-derived antidepressant-like peptide (REAP): An orally active novel tridecapeptide derived from rice protein	9
Engineering a potent and long-acting GLP-1/Y2 receptor dual agonist as a multi-agonist therapy for diabetes and obesity	9
Recent articles highlighting the multifunctional character and wider therapeutic potential of antimicrobial peptides	9
Irisin alleviates hyperoxia-induced bronchopulmonary dysplasia through activation of Nrf2/HO-1 pathway	9
Editorial Board	9
Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier	8
AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung remodelling	8
FGF4 alleviates renal injury caused by ischemia-reperfusion(I/R) by inhibiting ferroptosis and pyroptosis	8
Apelin-36 attenuates diabetic glomerular endothelial hyperpermeability via the KLF2/Occludin pathway	8
Post‑transplant trajectories and renal function associations of mid‑regional pro‑adrenomedullin, mid‑regional pro‑atrial natriuretic peptide, and copeptin in kidney transplant recipients	8
Abba J. Kastin – Tribute to the founding and honorary editor of PEPTIDES	8
Editorial Board	8
Structure and function of neurohypophysial hormones	8
Protective effects of PACAP against high glucose-induced inflammation on air-liquid interface corneal epithelium barrier	8
Involvement of relaxin-family peptide-3 receptor (RXFP3) in the ventral dentate gyrus of the hippocampus in spatial and fear memory in rats	8
LP2, a cyclic angiotensin-(1−7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice	8
GLP-1 receptor agonism and GIP receptor antagonism induce substantial alterations in enteroendocrine and islet cell populations in obese high fat fed mice	8
Nesfatin-1 is involved in hyperbaric oxygen-mediated therapeutic effects in high fat diet-induced hyperphagia in mice	8
Interleukin-6, undercarboxylated osteocalcin, and brain-derived neurotrophic factor responses to single and repeated sessions of high-intensity interval exercise	8
Discovery of the bioactive form of glucagon-like peptide-1: An attempt to correct some misconceptions	8
Host defense peptides at the crossroad of endothelial cell physiology: Insight into mechanistic and pharmacological implications	7
Amphibian host-defense peptides with potential for Type 2 diabetes therapy – an updated review	7
Optogenetics studies of kisspeptin neurons	7
Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects	7
Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals	7
Acute effects of peripherally administered nicotine on food intake via the central anorectic peptide nesfatin-1/nucleobindin-2 in adult male rats	7
Adropin: A cardio-metabolic hormone in the periphery, a neurohormone in the brain?	7
The impact of GLP-1 signalling on the energy metabolism of pancreatic islet β-cells and extrapancreatic tissues	7
Neprilysin deficiency reduces hepatic gluconeogenesis in high fat-fed mice	7
Endothelin-1 modulates hippocampal and hypothalamic neuronal network activity in mouse primary dissociated cultures and brain slices	7
Cbf-14, a cationic peptide derived from cathelin-domain, exhibits anti-inflammation activity via inhibiting PI3K- Akt /ROS/ NF-κB signaling pathway	7
Heart peptides and HFpEF (heart failure with preserved ejection fraction)	7
Functional role of immunoglobulin G as an oxytocin-carrier protein	7
Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives	7
Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway	7
Evaluation of plasma arginine vasopressin during hypertonic saline loading: A comparison of radioimmunoassay and liquid chromatography–tandem mass spectrometry	7
Phoenixin-14 ameliorates acetic acid-induced ulcerative colitis in rats via antioxidant, anti-inflammatory and anti-apoptotic mechanisms	7