Peptides

Article	Citations
Chemical modifications to increase the therapeutic potential of antimicrobial peptides	83
Nisin—A lantibiotic with immunomodulatory properties: A review	57
Immunomodulatory peptides—A promising source for novel functional food production and drug discovery	54
GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation	53
An update on peptide-based therapies for type 2 diabetes and obesity	45
The critical role of CCK in the regulation of food intake and diet-induced obesity	43
An overview of the insulin signaling pathway in model organisms Drosophila melanogaster and Caenorhabditis elegans	39
Antiviral peptides against Coronaviridae family: A review	38
Soybean proteins/peptides: A review on their importance, biosynthesis, vacuolar sorting, and accumulation in seeds	37
Antimicrobial peptides in domestic animals and their applications in veterinary medicine	30
Melanin-concentrating hormone and food intake control: Sites of action, peptide interactions, and appetition	30
Peptides to combat viral infectious diseases	29
Strategies for improving stability and pharmacokinetic characteristics of radiolabeled peptides for imaging and therapy	28
Effects of microbiome changes on endocrine ghrelin signaling – A systematic review	27
Peptides in the regulation of glucagon secretion	27
Arginine vasopressin: Direct and indirect action on metabolism	25
Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation	24
Vasopressin and copeptin release during sepsis and septic shock	23
An insight into biological activities of native cyclotides for potential applications in agriculture and pharmaceutics	23
PACAP orchestration of stress-related responses in neural circuits	23
Whether short peptides are good candidates for future neuroprotective therapeutics?	22
Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists	21
Liraglutide ameliorates lipotoxicity-induced inflammation through the mTORC1 signalling pathway	21
The role of diverse LURE-type cysteine-rich peptides as signaling molecules in plant reproduction	20
The role of kallikrein-kinin and renin-angiotensin systems in COVID-19 infection	20

Orexin (hypocretin) participates in central autonomic regulation during fight-or-flight response	20
Do orexin/hypocretin neurons signal stress or reward?	19
Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease	19
Plant-derived peptides improving lipid and glucose metabolism	19
Demystifying functional role of cocaine- and amphetamine-related transcript (CART) peptide in control of energy homeostasis: A twenty-five year expedition	18
Antimicrobial-wound healing peptides: Dual-function molecules for the treatment of skin injuries	18
The molecular pharmacology of glucagon agonists in diabetes and obesity	17
Modulation of cathelicidin and defensins by histone deacetylase inhibitors: A potential treatment for multi-drug resistant infectious diseases	17
Endogenous opiates and behavior: 2020	16
Appetite regulation by plant-derived bioactive peptides for promoting health	16
LP2, the first lanthipeptide GPCR agonist in a human pharmacokinetics and safety study	15
Potential of plant-derived peptides for the improvement of memory and cognitive function	15
Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool	15
Chemerin/CMKLR1 ameliorates nonalcoholic steatohepatitis by promoting autophagy and alleviating oxidative stress through the JAK2-STAT3 pathway	15
Hypotensive peptides derived from plant proteins	15
Involvement of complement peptides C3a and C5a in osteoarthritis pathology	14
CCHamide2-receptor regulates feeding behavior in the pea aphid, Acyrthosiphon pisum	14
Cathelicidin-NV from Nanorana ventripunctata effectively protects HaCaT cells, ameliorating ultraviolet B-induced skin photoaging	14
Endogenous opiates and behavior: 2019	14
Interactions between nesfatin-1 and the autonomic nervous system—An overview	14
Dulaglutide, a long-acting GLP-1 receptor agonist, can improve hyperandrogenemia and ovarian function in DHEA-induced PCOS rats	14
Biotechnological applications of versatile plant lipid transfer proteins (LTPs)	14
The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn	14
Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain	13
Pancreatic polypeptide revisited: Potential therapeutic effects in obesity-diabetes	13
Physiological functions and potential clinical applications of motilin	13
CLAVATA3, a plant peptide controlling stem cell fate in the meristem	13
An angiotensin-converting enzyme-2-derived heptapeptide GK-7 for SARS-CoV-2 spike blockade	13
Circulating microRNAs associated with C-type natriuretic peptide in childhood obesity	13
Host defense peptides as immunomodulators: The other side of the coin	12
Sublancin protects against methicillin-resistant Staphylococcus aureus infection by the combined modulation of innate immune response and microbiota	12
NDP-MSH treatment recovers marginal lungs during ex vivo lung perfusion (EVLP)	12
Roles of gastrointestinal polypeptides in intestinal barrier regulation	12
Ghrelin ameliorates cardiac fibrosis after myocardial infarction by regulating the Nrf2/NADPH/ROS pathway	12
Dipeptidyl peptidase-4 and GLP-1 interplay in STC-1 and GLUTag cell lines	12
A review of the antiviral activity of cationic antimicrobial peptides	12
Alamandine, a derivative of angiotensin-(1-7), alleviates sepsis-associated renal inflammation and apoptosis by inhibiting the PI3K/Ak and MAPK pathways	12
The impact of inflammatory stress on hypothalamic kisspeptin neurons: Mechanisms underlying inflammation-associated infertility in humans and domestic animals	12
Ghrelin mitigates MPP+-induced cytotoxicity: Involvement of ERK1/2-mediated Nrf2/HO-1 and endoplasmic reticulum stress PERK signaling pathway	12
Angiotensin-(1−7), a protective peptide against vascular aging	12
Root meristem growth factor RGF, a sulfated peptide hormone in plants	12
Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses	11
LL-37-induced caspase-independent apoptosis is associated with plasma membrane permeabilization in human osteoblast-like cells	11
NMR three-dimensional structure of the cationic peptide Stigmurin from Tityus stigmurus scorpion venom: In vitro antioxidant and in vivo antibacterial and healing activity	11
Prolactin neuroprotective action against excitotoxic insult in the hippocampus of male mice	11
Neuromodulatory peptides: Orally active anxiolytic-like and antidepressant-like peptides derived from dietary plant proteins	11
Irisin lowers blood pressure in Zucker diabetic rats by regulating the functions of renal angiotensin II type 1 receptor via the inhibition of the NF-κB signaling pathway	11
The renin-angiotensin system and cardiovascular autonomic control in aging	11
Angiotensin-(1-7) protects against sepsis-associated left ventricular dysfunction induced by lipopolysaccharide	11
Gap junction coupling and islet delta-cell function in health and disease	11

The truncated human beta-defensin 118 can modulate lipopolysaccharide mediated inflammatory response in RAW264.7 macrophages	11
Effect of diet-induced obesity on kisspeptin-neurokinin B-dynorphin A neurons in the arcuate nucleus and luteinizing hormone secretion in sex hormone-primed male and female rats	11
Evaluation of VGF peptides as potential anti-obesity candidates in pre-clinical animal models	11
Antioxidant and immunomodulatory potency of Lacticaseibacillus rhamnosus NCDC24 fermented milk-derived peptides: A computationally guided in-vitro and ex-vivo investigation	10
Molecular and functional characterization of the luqin-type neuropeptide signaling system in the sea cucumber Apostichopus japonicus	10
Physiological role of K+ channels in irisin-induced vasodilation in rat thoracic aorta	10
A synthetic peptide AWRK6 ameliorates metabolic associated fatty liver disease: involvement of lipid and glucose homeostasis	10
Acute social defeat stress upregulates gonadotrophin inhibitory hormone and its receptor but not corticotropin-releasing hormone and ACTH in the Male Nile Tilapia (Oreochromis niloticus)	10
Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: A longitudinal birth cohort study	10
Deletion of growth hormone receptor in hypothalamic neurons affects the adaptation capacity to aerobic exercise	10
Molecular mechanisms of plant peptide binding to receptors	10
Neuronal calcitonin gene-related peptide promotes prostate tumor growth in the bone microenvironment	10
Immunoneutralization of human angiotensin-(1-12) with a monoclonal antibody in a humanized model of hypertension	10
The mediation by GLP-1 receptors of glucagon-induced insulin secretion revisited in GLP-1 receptor knockout mice	10
ACE2 suppresses the inflammatory response in LPS-induced porcine intestinal epithelial cells via regulating the NF-κB and MAPK pathways	10
KNDy neurons as the GnRH pulse generator: Recent studies in ruminants	10
Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity	10
Diminazene Aceturate, an angiotensin converting enzyme 2 (ACE2) activator, promotes cardioprotection in ischemia/reperfusion-induced cardiac injury	10
Transcriptomic and proteomic analyses of venom glands from scorpions Liocheles australasiae, Mesobuthus martensii, and Scorpio maurus palmatus	9
Glucagon-like peptide-1 receptor promotes osteoblast differentiation of dental pulp stem cells and bone formation in a zebrafish scale regeneration model	9
Nociceptin/orphanin FQ receptor system blockade as an innovative strategy for increasing resilience to stress	9
Effect of Fc-Elabela-21 on renal ischemia/reperfusion injury in mice: Mediation of anti-apoptotic effect via Akt phosphorylation	9
Hypothalamic kisspeptin neurons as potential mediators of estradiol negative and positive feedback	9
Role of orexin receptors within the dentate gyrus in antinociception induced by chemical stimulation of the lateral hypothalamus in an animal model of inflammatory pain	9
Dual-agonist incretin peptides from fish with potential for obesity-related Type 2 diabetes therapy – A review	9
Surface megalin expression is a target to the inhibitory effect of bradykinin on the renal albumin endocytosis	9
LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders	9
Markers of the sympathetic, parasympathetic and sensory nervous system are altered in the human diabetic choroid	9
Cardio-protective effects of angiotensin-(1-5) via mas receptor in rats against ischemic-perfusion injury	9
The present and future of synthetic orexin receptor agonists	9
Structure and function of cationic hylin bioactive peptides from the tree frog Boana pulchella in interaction with lipid membranes	9
Effects and signaling pathways of Elabela in the cardiovascular system	9
The involvement of orexin 1 and cannabinoid 1 receptors within the ventrolateral periaqueductal gray matter in the modulation of migraine-induced anxiety and social behavior deficits of rats	9
Characterization of four urotensin II receptors (UTS2Rs) in chickens	9
Detection of neuropeptides in vivo and open questions for current and upcoming fluorescent sensors for neuropeptides	9
Reptilian β-defensins: Expanding the repertoire of known crocodylian peptides	9
Corticotropin-releasing factor receptor 1 (CRF-R1) antagonists: Promising agents to prevent visceral hypersensitivity in irritable bowel syndrome	9
Postnatal AVP treatments prevent social deficit in adolescence of valproic acid-induced rat autism model	9
Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1–PPAR-α–Kisspeptin–Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model	8
Interplay of circulating leptin and obesity in cognition and cerebral volumes in older adults	8
The LL-37 domain: A clue to cathelicidin immunomodulatory response?	8
Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults	8
Apelin improves cardiac function mainly through peripheral vasodilation in a mouse model of dilated cardiomyopathy	8
Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity	8
Beneficial effects of galanin system on diabetic peripheral neuropathic pain and its complications	8
Involvement of orexin-2 receptors in the CA1 region of the hippocampus in the extinction and reinstatement of methamphetamine-induced conditioned place preference in the rats	8
Associations of serum kisspeptin levels with metabolic and reproductive parameters in men	8
Intracerebroventricular administration of α-melanocyte-stimulating hormone (α-MSH) enhances thigmotaxis and induces anxiety-like behavior in the goldfish Carassius auratus	8
Exploring the role of glycoprotein hormone GPA2/GPB5 in the medically important insect, Rhodnius prolixus	8
The SNX-482 peptide from Hysterocrates gigas spider acts as an immunomodulatory molecule activating macrophages	8
The role of spexin in energy metabolism	8
Structural and functional characterization of NDBP-4 family antimicrobial peptides from the scorpion Mesomexovis variegatus	8
Post-translationally modified conopeptides: Biological activities and pharmacological applications	8
Synthetic peptide SVVYGLR upregulates cell motility and facilitates oral mucosal wound healing	8
Impact of angiotensin II type 1 and G-protein-coupled Mas receptor expression on the pulmonary performance of patients with idiopathic pulmonary fibrosis	8
Roles of Angiotensin III in the brain and periphery	8
Identification of a crocodylian β-defensin variant from Alligator mississippiensis with antimicrobial and antibiofilm activity	8
CASPARIAN STRIP INTEGRITY FACTOR (CIF) family peptides - regulator of plant extracellular barriers	8
Antimicrobial peptide production in response to gut microbiota imbalance	8
Estrogen and gut satiety hormones in vagus-hindbrain axis	8
Antiosteoporosis effects of a marine antimicrobial peptide pardaxin via regulation of the osteogenesis pathway	8
Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier	8
Blood and aqueous humor phoenixin, endocan and spexin in patients with diabetes mellitus and cataract with and without diabetic retinopathy	8
The neuropeptide SMYamide, a SIFamide paralog, is expressed by salivary gland innervating neurons in the American cockroach and likely functions as a hormone	7
Angiotensin-(1-7) reduces doxorubicin-induced aortic arch dysfunction in male and female juvenile Sprague Dawley rats through pleiotropic mechanisms	7
Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10	7
Effects of neuropeptide Y as a feed additive on stimulating the growth of tilapia (Oreochromis niloticus) fed low fish meal diets	7
Alamandine, a new member of the renin-angiotensin system (RAS), attenuates collagen-induced arthritis in mice via inhibiting cytokine secretion in synovial fibroblasts	7
Mendelian randomization study of the relation between adiponectin and heart function, unravelling the paradox	7
Autonomic control of pancreatic beta cells: What is known on the regulation of insulin secretion and beta-cell proliferation in rodents and humans	7
Modulatory role of PACAP and VIP on HIFs expression in lung adenocarcinoma	7
Glucagon and energy expenditure; Revisiting amino acid metabolism and implications for weight loss therapy	7
Oxytocin ameliorates KCC2 decrease induced by oral bacteria-derived LPS that affect rat primary cultured cells and PC-12 cells	7
The effect of acute exercise on pre-prandial ghrelin levels in healthy adults: A systematic review and meta-analysis	7
Transforming growth factor-β induced protein regulates pulmonary fibrosis via the G-protein signaling modulator 2 /Snail axis	7
Albumin binding Nanofitins, a new scaffold to extend half-life of biologics – a case study with exenatide peptide	7
Circadian and kisspeptin regulation of the preovulatory surge	7
C-peptide ameliorates high glucose-induced podocyte dysfunction through the regulation of the Notch and TGF-β signaling pathways	7
Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice	7
Identification of cells expressing Calcitonins A and B, PDF and ACP in Locusta migratoria using cross-reacting antisera and in situ hybridization	7

The glucagon-like peptide-1 (GLP-1) analog exenatide ameliorates intrauterine adhesions in mice	7
Evolution of the mammalian insulin (Ins) gene; Changes in proteolytic processing	7
Irisin alleviates high glucose-induced hypertrophy in H9c2 cardiomyoblasts by inhibiting endoplasmic reticulum stress	7
Neandertal introgression and accumulation of hypomorphic mutations in the neuropeptide S (NPS) system promote attenuated functionality	7
The non-cardiovascular actions of ACE	7
Cellular processes involved in RAW 264.7 macrophages exposed to NPFF: A transcriptional study	7
Parkinson disease: Protective role and function of neuropeptides	7
Ghrelin inhibited pressure overload–induced cardiac hypertrophy by promoting autophagy via CaMKK/AMPK signaling pathway	7
Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells	7
Pathogen- and plant-derived peptides trigger plant immunity	7