OOIR: Observatory of International Research

Papers

(The TQCC of Peptides is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
The first structure-activity relationship study of oxytocin as a positive allosteric modulator for the µ opioid receptor	92
Editorial Board	53
Editorial Board	43
PCP consensus protein/peptide alphavirus antigens stimulate broad spectrum neutralizing antibodies	43
Gut hormone analogues and skeletal health in diabetes and obesity: Evidence from preclinical models	40
Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity	40
Angiotensin-(1−7), a protective peptide against vascular aging	31
Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats	31
Transcardiac gradients of pro-cholecystokinin, cholecystokinin, and gastrin in patients with and without heart failure with reduced ejection fraction	31
Corrigendum to “Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis” [Peptides 182 (2024) 171323]	31
Serum alanine transaminase is predictive of fasting and postprandial insulin and glucagon concentrations in type 2 diabetes	30
KNDy neurons as the GnRH pulse generator: Recent studies in ruminants	29
The present and future of synthetic orexin receptor agonists	28
Desacyl-ghrelin, not just an inactive form of ghrelin? A review of current knowledge on the biological actions of desacyl-ghrelin	26
Nesfatin-1 regulates steroidogenesis in mouse Leydig cells	26
The antimicrobial peptide Abaecin alleviates colitis in mice by regulating inflammatory signaling pathways and intestinal microbial composition	26
The impact of multifunctional enkephalin analogs and morphine on the protein changes in crude membrane fractions isolated from the rat brain cortex and hippocampus	25
Studies on the in vitro mechanism and in vivo therapeutic effect of the antimicrobial peptide ACP5 against Trichophyton mentagrophytes	25
Asprosin-mediated regulation of ovarian functions in mice: An age-dependent study	24
Editorial Board	23
Editorial Board	23
Editorial Board	23
Peptides and primate personality: Central and peripheral oxytocin and vasopressin levels and social behavior in two baboon species (Papio hamadryas and Papio anubis)	20
The protective role of Nesfatin-1 against TNF-α-induced ferroptosis in chondrocytes: Implications for osteoarthritis therapy	20
A chimeric natriuretic peptide (Ev-NP) inhibits isoproterenol (ISO)-induced hypertrophic growth in in vivo and in vitro models by enhancing cGMP and its downstream signaling targets: In silico docking	19

Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development	19
VR-10 polypeptide interacts with CD36 to induce cell apoptosis and autophagy in choroid-retinal endothelial cells: Identification of VR-10 as putative novel therapeutic agent for choroid neovasculariz	19
Impact of galanin receptors 2 and 3 double-knockout on neuroinflammation and functional recovery following traumatic brain injury	18
Suppression of B-type natriuretic peptide gene expression in cardiomyocytes under anoxic conditions	18
Glucagon-like peptide-1 receptor promotes osteoblast differentiation of dental pulp stem cells and bone formation in a zebrafish scale regeneration model	17
Modulatory role of neuropeptide FF system in macrophages	16
Endogenous opiates and behavior: 2024	16
Synthesis, conformation and cytotoxic activity of short hybrid peptides containing conformationally constrained 1-(aminomethyl)cyclohexanecarboxylic acid and gabapentin	16
Editorial Board	15
Dulaglutide accelerates diabetic wound healing by suppressing Nrf2-dependent ferroptosis in diabetic mice	15
Recombinant production of isotope-labeled human α-defensin 5 via calmodulin fusion and insights into its expression enhancement	15
Lasso peptides realm: Insights and applications	15
GIP-derived GIP receptor antagonists – a review of their role in GIP receptor pharmacology	15
Allatotropin (AT) related peptides L-ATRP and D2-ATRP diastereomers activate an endogenous receptor and suppress heart rate in the Pacific abalone Haliotis discus hannai	15
Dysfunction of the renin-angiotensin-aldosterone system in human septic shock	15
Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells	14
A novel endomorphin-2/salmon calcitonin hybrid peptide with enhancing anti-allodynic and anti-anxiety effects	14
JHP-7 (QLLEELKR), a heptapeptide derived from Jinhua ham, may ameliorate intrauterine adhesion (IUA) via inhibiting inflammatory response and apoptosis	14
Erythropoietin attenuates lead-induced spatial memory deficits and anxiety-like behavior by suppressing hippocampal oxidative stress, cell death inhibition, and inflammation reduction	14
Influence of the angiotensin-(1−7) on the vascular effects of the endothelin-1 in normotensive and hypertensive rats	14
Glucagon and energy expenditure; Revisiting amino acid metabolism and implications for weight loss therapy	13
The T-1 conotoxin μ-SrVA from the worm hunting marine snail Conus spurius preferentially blocks the human NaV1.5 channel	13
The intricate relationship between circadian rhythms and gastrointestinal peptides in obesity	13
Significance of D- tryptophan in Contryphan-Ar1131 Conus peptide: Oxidative folding, trypsin binding, and photostabilization activity	13
Investigation of irisin's role in pubertal onset physiology in female rats	13
Reduced plasma cortistatin is related to clinical parameters in patients with essential hypertension	13
Endogenous opiates and behavior: 2023	13
Editorial Board	13
The role of leptin and ghrelin in the regulation of appetite in obesity	13
Glucagon-based therapy for people with diabetes and obesity: What is the sweet spot?	12
Venomous gland transcriptome and venom proteomic analysis of the scorpion Androctonus amoreuxi reveal new peptides with anti-SARS-CoV-2 activity	12
Targeting the GLP-2 receptor in the management of obesity	12
Peptides as mediators of stress responses	12
PACAP inhibits sepsis-associated acute lung injury by inhibiting the Sp1/AQP1 pathway	12
Rational antimicrobial peptide engineering through amino acid scanning and targeted point mutations	12
Corrigendum to “Liraglutide inhibited AGEs induced coronary smooth muscle cell phenotypic transition through inhibiting the NF-κB signal pathway” [Peptides 112 (2019) 125–132]	11
Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol	11
Estrogens impair hypophagia and hypothalamic cell activation induced by vasoactive intestinal peptide, but not by pituitary adenylate cyclase-activating polypeptide	11
The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats	11
The effects of corticotropin-releasing factor (CRF) and urocortins on the noradrenaline (NA) released from the locus coeruleus (LC)	11
Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats	10
Liraglutide suppresses ferroptosis by upregulation NRF2 in type 2 diabetic cardiomyopathy	10
Activity dependent neuroprotective protein mediates the protective effects against VEGF-induced corneal barrier disruption in diabetes	10
Editorial: Special issue novel aspects of islet peptides	10
Role of brain NUCB2/nesfatin-1 in stress and stress-related gastrointestinal disorders	10
Egg white-derived peptide KPHAEVVLR promotes wound healing in rat palatal mucosa via PI3K/AKT/mTOR pathway	10
Spexin expression in the human bile duct and perihilar cholangiocarcinoma	10
Effect of pregnancy on the expression of nutrient-sensors and satiety hormones in mice	10
Body weight modulates the impact of oxytocin on chronic cold-immobilization stress response	10
The non-cardiovascular actions of ACE	10

Structure and function of neurohypophysial hormones	9
Angiotensin-(1−7) attenuates the negative inotropic response to acetylcholine in the heart	9
Tirzepatide improves angiogenesis after diabetic hindlimb ischemia through Akt/eNOS and ERK1/2 pathways	9
Synergistic interaction between DAMGO-NH2 and NOP01 in peripherally acting antinociception in two mouse models of formalin pain	9
Recent articles highlighting the multifunctional character and wider therapeutic potential of antimicrobial peptides	9
Apelin-36 attenuates diabetic glomerular endothelial hyperpermeability via the KLF2/Occludin pathway	9
Editorial Board	9
Alamandine attenuates oxidative stress in the right carotid following transverse aortic constriction in mice	9
Neuropeptides affecting social behavior in mammals: Oxytocin	9
Characterization of rice endosperm-derived antidepressant-like peptide (REAP): An orally active novel tridecapeptide derived from rice protein	9
Protective effects of PACAP against high glucose-induced inflammation on air-liquid interface corneal epithelium barrier	9
AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung remodelling	9
Editorial Board	9
Maximizing cost savings in heart failure management: The economic value of natriuretic peptide testing	9
Irisin alleviates hyperoxia-induced bronchopulmonary dysplasia through activation of Nrf2/HO-1 pathway	9
FGF4 alleviates renal injury caused by ischemia-reperfusion(I/R) by inhibiting ferroptosis and pyroptosis	9
Engineering a potent and long-acting GLP-1/Y2 receptor dual agonist as a multi-agonist therapy for diabetes and obesity	8
Angiotensin-(1-7) reduces doxorubicin-induced aortic arch dysfunction in male and female juvenile Sprague Dawley rats through pleiotropic mechanisms	8
Involvement of relaxin-family peptide-3 receptor (RXFP3) in the ventral dentate gyrus of the hippocampus in spatial and fear memory in rats	8
The impact of GLP-1 signalling on the energy metabolism of pancreatic islet β-cells and extrapancreatic tissues	8
Editorial Board	8
GLP-1 receptor agonism and GIP receptor antagonism induce substantial alterations in enteroendocrine and islet cell populations in obese high fat fed mice	8
Nesfatin-1 is involved in hyperbaric oxygen-mediated therapeutic effects in high fat diet-induced hyperphagia in mice	8
Discovery of the bioactive form of glucagon-like peptide-1: An attempt to correct some misconceptions	8
LP2, a cyclic angiotensin-(1−7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice	8
Interleukin-6, undercarboxylated osteocalcin, and brain-derived neurotrophic factor responses to single and repeated sessions of high-intensity interval exercise	8
Role of sexually dimorphic oxytocin receptor-expressing neurons in the anteroventral periventricular nucleus on maternal behavior	8
Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier	8
Abba J. Kastin – Tribute to the founding and honorary editor of PEPTIDES	8
Post‑transplant trajectories and renal function associations of mid‑regional pro‑adrenomedullin, mid‑regional pro‑atrial natriuretic peptide, and copeptin in kidney transplant recipients	8
Adropin: A cardio-metabolic hormone in the periphery, a neurohormone in the brain?	7
Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway	7
Neprilysin deficiency reduces hepatic gluconeogenesis in high fat-fed mice	7
Heart peptides and HFpEF (heart failure with preserved ejection fraction)	7
Evaluation of plasma arginine vasopressin during hypertonic saline loading: A comparison of radioimmunoassay and liquid chromatography–tandem mass spectrometry	7
A short framework-III (mini-M-2) conotoxin from the venom of a vermivorous species, Conus archon, inhibits human neuronal nicotinic acetylcholine receptors	7
Optogenetics studies of kisspeptin neurons	7
Amphibian host-defense peptides with potential for Type 2 diabetes therapy – an updated review	7
Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives	7
Functional role of immunoglobulin G as an oxytocin-carrier protein	7
Acute effects of peripherally administered nicotine on food intake via the central anorectic peptide nesfatin-1/nucleobindin-2 in adult male rats	7
Host defense peptides at the crossroad of endothelial cell physiology: Insight into mechanistic and pharmacological implications	7
Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects	7
Endothelin-1 modulates hippocampal and hypothalamic neuronal network activity in mouse primary dissociated cultures and brain slices	7
PD1 CD44 antiviral peptide as an inhibitor of the protein-protein interaction in dengue virus invasion	7