OOIR: Observatory of International Research

Papers

(The TQCC of Lasers in Surgery and Medicine is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations	73
Energy‐based devices for the treatment of Acne Scars: 2022 International consensus recommendations	33
Deep Learning in Biomedical Optics	30
Strategies to Improve the Antimicrobial Efficacy of Photodynamic, Sonodynamic, and Sonophotodynamic Therapies	28
Fractional 1064 nm Picosecond Laser in Treatment of Melasma and Skin Rejuvenation in Asians, A Prospective Study	27
A Prospective, Split‐Face, Randomized Study Comparing a 755‐nm Picosecond Laser With and Without Diffractive Lens Array in the Treatment of Melasma in Asians	24
Hypertrophic Scar Improvement by Early Intervention With Ablative Fractional Carbon Dioxide Laser Treatment	23
Photobiomodulation‐Induced Differentiation of Immortalized Adipose Stem Cells to Neuronal Cells	18
Stone ablation rates using innovative pulse modulation technology: Vapor tunnel, virtual basket, and bubble blast. An in vitro experimental study	18
Objective and Long‐Term Evaluation of the Efficacy and Safety of a 1064‐nm Picosecond Laser With Fractionated Microlens Array for the Treatment of Atrophic Acne Scar in Asians	17
Characteristics of the Irrigant Flow in a Simulated Lateral Canal Under Two Typical Laser‐Activated Irrigation Regimens	17
Evaluation of Fractional CO₂ Versus Long Pulsed Nd:YAG Lasers in Treatment of Hypertrophic Scars and Keloids: A Randomized Clinical Trial	17
Effects of Rose Bengal‐ and Methylene Blue‐Mediated Potassium Iodide‐Potentiated Photodynamic Therapy on Enterococcus faecalis: A Comparative Study	16
Oxymetazoline and Energy‐Based Therapy in Patients with Rosacea: Evaluation of the Safety and Tolerability in an Open‐Label, Interventional Study	15
Heterogeneous Features of Keloids Assessed by Laser Speckle Contrast Imaging: A Cross‐Sectional Study	14
Combining Nd:YAG laser with optical coherence tomography for nonsurgical treatment of basal cell carcinoma	14
Comparing the Bone Healing After Cold Ablation Robot‐Guided Er:YAG Laser Osteotomy and Piezoelectric Osteotomy—A Pilot Study in a Minipig Mandible	14
Electronic Pneumatic Injection‐Assisted Dermal Drug Delivery Visualized by Ex Vivo Confocal Microscopy	14
Treatment of melasma with a low‐fluence 1064 nm Q‐switched Nd:YAG laser: Laser toning in Caucasian women	14
Fractional Co₂ Laser Treatment of the Vulva and Vagina and the Effect of Postmenopausal Duration on Efficacy	14
Application of OCT‐Derived Attenuation Coefficient in Acute Burn‐Damaged Skin	13
Evaluating the effectiveness and safety of radiofrequency for face and neck rejuvenation: A systematic review	13
A Prospective Study Evaluating the Use of Helium Plasma for Dermal Resurfacing	13
Hydrogen‐Peroxide‐Responsive Protein Biomimetic Nanoparticles for Photothermal‐Photodynamic Combination Therapy of Melanoma	13
Measurement of Simulated Debris Removal Rates in an Artificial Root Canal to Optimize Laser‐Activated Irrigation Parameters	13

Comparative Effectiveness of 755‐nm Picosecond Laser, 755‐ and 532‐nm Nanosecond Lasers for Treatment of Café‐au‐Lait Macules (CALMs): A Randomized, Split‐Lesion Clinical Trial	12
A 12‐Week, Prospective, Non‐Comparative, Non‐Randomized Study of Magnetic Muscle Stimulation for Improvement of Body Satisfaction With the Abdomen and Buttocks	12
Ablative Fractional Carbon Dioxide Laser and Autologous Platelet‐Rich Plasma in the Treatment of Atrophic Acne Scars: A Comparative Clinico‐Immuno‐Histopathological Study	12
Laser‐Induced Differentiation of Human Adipose‐Derived Stem Cells to Temporomandibular Joint Disc Cells	12
Reflectance Confocal Microscopy, Optical Coherence Tomography, and Multiphoton Microscopy in Inflammatory Skin Disease Diagnosis	12
Clinical and histologic evaluation of a fractional radiofrequency treatment of wrinkles and skin texture with novel 1‐mm long ultra‐thin electrode pins	12
Fractional‐Pixel CO₂ Laser Treatment in Patients With Urodynamic Stress Urinary Incontinence: 1‐Year Follow‐Up	11
Fractional Carbon Dioxide Laser Versus Carboxytherapy in Treatment of Striae Distensae	11
The Fractional CO₂ Laser for the Treatment of Genitourinary Syndrome of Menopause: A Prospective Multicenter Cohort Study	11
Device‐Induced Neocollagenesis: Profibrotic Response or True Neocollagenesis?	11
Topical 0.5% Timolol Maleate Significantly Enhances Skin‐Barrier Restoration After Fractional Carbon Dioxide Laser Treatment for Acne Scars	11
Quantitative and Qualitative Evaluation of Supercontinuum Laser‐Induced Cutaneous Thermal Injuries and Their Repair With OCT Images	11
The Efficacy and Safety of CO₂ Laser Treatment for Sexual Function and Vaginal Laxity Improvement in Pre‐Menopausal Women	11
Fractional Microablative CO₂ Laser‐Related Histological Changes on Vulvar Tissue in Patients With Genitourinary Syndrome of Menopause	11
Photobiomodulation Response From 660 nm is Different and More Durable Than That From 980 nm	11
Quantitative assessment of the long‐term efficacy and safety of a 1064‐nm picosecond laser with fractionated microlens array in the treatment of enlarged pores in Asians: A case‐control study	10
Fractional Radiofrequency Microneedling Combined With Fractional Carbon Dioxide Laser Treatment for Striae Distensae	10
Wound Healing Profile After 1064‐ and 532‐nm Picosecond Lasers With Microlens Array of In Vivo Human Skin	10
A Randomized Controlled Pilot Study: Combined 595‐nm Pulsed Dye Laser Treatment and Oxymetazoline Hydrochloride Topical Cream Superior to Oxymetazoline Hydrochloride Cream for Erythematotelangiectatic	10
Efficacy and Safety of Topical Silymarin Versus Low Fluence 1064‐nm Q Switched Nd:YAG Laser in the Treatment of Melasma: A Comparative Randomized Trial	10
Efficacy and Safety of Laser‐Assisted Combination Chemotherapy: An Explorative Imaging‐Guided Treatment With 5‐Fluorouracil and Cisplatin for Basal Cell Carcinoma	10
Non‐Ablative 1927 nm Fractional Thulium Fiber Laser: New, Promising Treatment Modality for Riehl's Melanosis	10
Single Treatment Protocol With Microneedle Fractional Radiofrequency for Treatment of Body Skin Laxity and Fat Deposits	10
A Comparison of Human and Porcine Skin in Laser‐Assisted Drug Delivery of Chemotherapeutics	10
The state of the art of biomedical applications of optogenetics	10
Improvement in the appearance of cellulite and skin laxity resulting from a single treatment with acoustic subcision: Findings from a multicenter pivotal clinical trial	10
Clinical Study Demonstrates that Electromagnetic Muscle Stimulation Does Not Cause Injury to Fat Cells	10
Comparison of Fractional Micro‐Plasma Radiofrequency and Fractional Microneedle Radiofrequency for the Treatment of Atrophic Acne Scars: A Pilot Randomized Split‐Face Clinical Study in China	10
Machine Learning‐Based Optoacoustic Tissue Classification Method for Laser Osteotomes Using an Air‐Coupled Transducer	10
Optical Coherence Tomography‐Assisted Evaluation of Fractional Er:YAG Laser Versus Fractional Microneedling Radiofrequency in Treating Striae Alba	9
Treatment of facial and non‐facial lentigines with a 730 nm picosecond titanium: Sapphire laser is safe and effective	9
Skin of color representation in cosmetic clinical trials: A literature review	9
Thermomechanical Ablation‐Assisted Photodynamic Therapy for the Treatment of Acne Vulgaris. A Retrospective Chart Review of 30 Patients	9
Predicting Metastasis in Melanoma by Enumerating Circulating Tumor Cells Using Photoacoustic Flow Cytometry	9
Topical Delivery of Nivolumab, a Therapeutic Antibody, by Fractional Laser and Pneumatic Injection	9
Tumor Clearance and Immune Cell Recruitment in UV‐Induced Murine Squamous Cell Carcinoma Exposed to Ablative Fractional Laser and Imiquimod Treatment	9
Does the Time of Onset of Urinary Symptoms Affect Microablative Fractional CO₂ Laser Efficacy in Postmenopausal Women?	9
Management of oral leukoplakia by ablative fractional laser‐assisted photodynamic therapy: A 3‐year retrospective study of 48 patients	9
Standardization of Pre‐ and Postoperative Management Using Laser Epilation and Oxygen‐Enriched Oil‐Based Gel Dressing in Pediatric Patients Undergoing Pediatric Endoscopic Pilonidal Sinus Treatment (P	9
Vascularity and Thickness Changes in Immature Hypertrophic Scars Treated With a Pulsed Dye Laser	9
Photobiomodulation Therapy is Able to Modulate PGE₂ Levels in Patients With Chronic Non‐Specific Low Back Pain: A Randomized Placebo‐Controlled Trial	9
Successful Treatment of Pigmentary Disorders in Asians With a Novel 730‐nm Picosecond Laser	9
The Efficacy and Safety of Fractional 1064 nm Nd:YAG Picosecond Laser Combined With Intense Pulsed Light in the Treatment of Atrophic Acne Scar: A Split‐Face Study	9
Scattering‐Based Light‐Sheet Microscopy for Rapid Cellular Imaging of Fresh Tissue	9
Combined Low‐Dose Isotretinoin and Pulsed Dye Laser Versus standard‐Dose Isotretinoin in the Treatment of Inflammatory Acne	9
Adverse Events of Intense Pulsed Light Combined With Meibomian Gland Expression Versus Meibomian Gland Expression in the Treatment of Meibomian Gland Dysfunction	9
Incident Fluence Analysis for 755‐nm Picosecond Laser Treatment of Pigmented Skin Lesions Based on Threshold Fluences for Melanosome Disruption	9
Intraductal Lithotripsy in Sialolithiasis Using the Calculase III™ Ho:YAG Laser: First Experiences	8
Fabrication and characterization of chitosan nanoparticles using the coffee‐ring effect for photodynamic therapy	8
A Clinical Perspective on the Automated Analysis of Reflectance Confocal Microscopy in Dermatology	8

Comparison of 1064‐nm and Dual‐Wavelength (532/1064‐nm) Picosecond‐Domain Nd:YAG Lasers in the Treatment of Facial Photoaging: A Randomized Controlled Split‐Face Study	8
Determination of Optimal Separation Times for Dual‐Pulse SWEEPS Laser‐Assisted Irrigation in Different Endodontic Access Cavities	8
Novel Application of the 730 and 785 nm Picosecond Titanium Sapphire Lasers for the Treatment of Nevus of Ota	8
Safety and efficacy of fractional radiofrequency for the treatment and reduction of acne scarring: A prospective study	8
Treatment of abdominal striae distensae in Fitzpatrick skin types IV to V using a 1064‐nm picosecond laser with a fractionated microlens array	8
Laser‐Assisted Hyaluronic Acid Delivery by Fractional Carbon Dioxide Laser in Facial Skin Remodeling: A Prospective Randomized Split‐Face Study in France	8
Veno‐venous extracorporeal blood phototherapy increases the rate of carbon monoxide (CO) elimination in CO‐poisoned pigs	8
Photobiomodulation Therapy on Myocardial Infarction in Rats: Transcriptional and Posttranscriptional Implications to Cardiac Remodeling	8
Modified 5‐aminolevulinic acid photodynamic therapy reduces pain and improves therapeutic effects in cutaneous squamous cell carcinoma mouse model	8
Picosecond Laser treatment of Striae Distensae: In vivo Evaluation of Results by 3D Analysis, Reflectance Confocal Microscopy, and Patient′s Satisfaction	8
Picosecond‐Domain Fractional Laser Treatment Over Hyaluronic Acid Fillers: In Vivo and Clinical Studies	8
Safety and Efficacy of Blue Light Laser Treatment in Hereditary Hemorrhagic Telangiectasia	8
Combinatory Effect of ALA‐PDT and Itraconazole Treatment for Trichosporon asahii	8
OCT‐Based Angiography and Surface Topography in Burn‐Damaged Skin	7
Safety and efficacy of endovenous laser ablation (EVLA) using 1940 nm and radial emitting fiber: 3‐year results of a prospective, non‐randomized study and comparison with 1470 nm	7
Selective Cryolysis of Melanocytes: Critical Temperature and Exposure Time to Induce Selective Pigmentary Loss in Yucatan Pig Skin	7
Characteristics of Non‐Ablative Resurfacing of Soft Tissues by Repetitive Er:YAG Laser Pulse Irradiation	7
Combining Deep Learning With Optical Coherence Tomography Imaging to Determine Scalp Hair and Follicle Counts	7
Low‐Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% to Bring a Sustainable Hair Regrowth Activity	7
Treatment of periorbital wrinkles using thermo‐mechanical fractional injury therapy versus fractional non‐ablative 1565 nm laser: A comparative prospective, randomized, double‐arm, controlled study	7
Combined CO₂ and dye laser technique in the treatment of outcomes due to flap necrosis after surgery for basal cell carcinoma on the nose	7
Photobiomodulation therapy for the prevention of acute radiation dermatitis in breast cancer patients undergoing hypofractioned whole‐breast irradiation (LABRA trial)	7
The efficacy and safety of low‐energy carbon dioxide fractional laser use in the treatment of early‐stage pediatric hypertrophic scars: A prospective, randomized, split‐scar study	7
Efficacy and safety of laser‐assisted combination chemotherapy: A follow‐up study of treatment with 5‐fluorouracil and cisplatin for basal cell carcinoma	7
Identification of oral precancerous and cancerous tissue by swept source optical coherence tomography	7
Systemic Effects of Cryolipolysis in Central Obese Women: A Randomized Controlled Trial	7
Assessment of natural antioxidants' effect on PDT cytotoxicity through fluorescence microscopy image analysis	7
Clinical endpoints of needle‐free jet injector treatment: An in depth understanding of immediate skin responses	7
Improved healing and macrophage polarization in oral ulcers treated with photobiomodulation (PBM)	7
A Randomized, Split‐Face, Double‐Blind Comparison Trial Between Fractionated Frequency‐Doubled 1064/532 nm Picosecond Nd:YAG Laser and Fractionated 1927 nm Thulium Fiber Laser for Facial Photorejuvena	7
Combination of a 755‐nm picosecond laser and hydroquinone 2% cream versus hydroquinone 2% cream alone for the treatment of melasma: A randomized, split‐face, and controlled trial	7
The Effect of Intense Pulsed Light on the Skin Microbiota and Epidermal Barrier in Patients with Mild to Moderate Acne Vulgaris	7
Safety and Efficacy of Nano‐Pulse Stimulation Treatment of Non‐Genital, Cutaneous Warts (Verrucae)	7
Thermo‐Mechanical Fractional Injury Therapy for Facial Skin Rejuvenation in Skin Types II to V: A Retrospective Double‐Center Chart Review	7
Efficacy of Photodynamic Anti‐Microbial Chemotherapy for Acanthamoeba Keratitis In Vivo	7
Vaginal Fractional Carbon Dioxide Laser Treatment and Changes in Vaginal Biomechanical Parameters	7
One‐Year Functional and Anatomical Outcomes After Selective Retina Therapy With Real‐Time Feedback‐Controlled Dosimetry in Patients With Intermediate Age‐Related Macular Degeneration: A Pilot Study	7
Effect of the Combination of Different Electrode Spacings and Power on Bipolar Radiofrequency Fat Dissolution: A Computational and Experimental Study	7
Photodetection and Safety of 5‐Aminolevulinic Acid‐Induced Porphyrin in Patients With Cervical Intraepithelial Neoplasia	7
High Diagnostic Accuracy of Visible 5‐ALA Fluorescence in Meningioma Surgery According to Histopathological Analysis of Tumor Bulk and Peritumoral Tissue	7
Pathological Changes in Axillary Hyperhidrosis and Axillary Osmidrosis Induced by Microwave Treatment: Comparison of Single‐ and Double‐Pass Irradiation	6
Analysis of port‐wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping	6
Crescent‐Shaped Hyperpigmentation Following Laser Hair Removal: Case Series of Fifteen Patients	6
Efficacy of Minoxidil Combined With Photobiomodulation for the Treatment of Male Androgenetic Alopecia. A Double‐Blind Half‐Head Controlled Trial	6
Pixel CO₂ Laser for the Treatment of Stress Urinary Incontinence: A Prospective Observational Multicenter Study	6
High Contrast Reflectance Imaging of Enamel Demineralization and Remineralization at 1950‐nm for the Assessment of Lesion Activity	6
Removing Subcutaneous Microvessels Using Photo‐Mediated Ultrasound Therapy	6
Demineralization Inhibition by High‐Speed Scanning of 9.3 µm CO ₂ Single Laser Pulses Over Enamel	6
Combining Low Power Fractional CO₂ With QS‐NdYAG Toning in the Treatment of Melasma Reduces the Incidence of Punctate Leukoderma	6
Effect of Optimized Irrigation With Photon‐Induced Photoacoustic Streaming on Smear Layer Removal, Dentin Microhardness, Attachment Morphology, and Survival of the Stem Cells of Apical Papilla	6
Thermo‐Mechanical Fractional Injury Enhances Skin Surface‐ and Epidermis‐ Protoporphyrin IX Fluorescence: Comparison of 5‐Aminolevulinic Acid in Cream and Gel Vehicles	6
Control of Burn Wound Infection by Methylene Blue‐Mediated Photodynamic Treatment With Light‐Emitting Diode Array Illumination in Rats	6
Three‐Year Results of Facial Photoaging in Asian Patients After Alexandrite 755 nm Picosecond Laser With Diffractive Lens Array: A Split‐Face, Single‐Blinded, Randomized Controlled Comparison	6
	6
Biochemical and Pain Comparisons Between the Laser Lancing Device and Needle Lancets for Capillary Blood Sampling: A Randomized Control Trial	6
Development of a Predictive Monte Carlo Radiative Transfer Model for Ablative Fractional Skin Lasers	5
Assessment of adverse events for a home‐use intense pulsed light hair removal device using postmarketing surveillance	5
Dynamic Optical Coherence Tomography Imaging of Telangiectasia Prior to Intense Pulsed Light Treatment—An Opportunity to Target Treatment?	5
Morphometric Optical Imaging of Microporated Nail Tissue: An Investigation of Intermethod Agreement, Reliability, and Technical Limitations	5
Fractional CO₂ laser treatment as adjunctive therapy to topical steroids for managing vulvar lichen sclerosus	5
Deep Learning‐Based Denoising in High‐Speed Portable Reflectance Confocal Microscopy	5
On‐Site Laser Photobiomodulation Treatment of Crushed Muscle Due to Prolonged Pressure in Rats	5
Analysis of the Curative Effect of Alexandrite Laser in the Treatment of Venous Lake of Lips	5
A Multi‐Site, Single‐Blinded, Prospective Pilot Clinical Trial for Non‐Invasive Fat Reduction of the Abdomen and Flanks Using a Monopolar 2 MHz Radiofrequency Device	5
Clinical and Histological Assessment of Combined Fractional CO₂ Laser and Growth Factors Versus Fractional CO₂ Laser Alone in the Treatment of Facial Mature Burn Scars: A Pilot S	5
Repeated exposure to fractional CO₂ laser delays squamous cell carcinoma formation and prevents clinical and subclinical photodamage visualized by line‐field confocal optical coherence tomo	5
Procedure and results on lower face and neck rejuvenation using a temperature‐controlled bipolar fractional radiofrequency microneedling device	5
Effects of Pulsed‐Wave Photobiomodulation Therapy on Human Spermatozoa	5
Abstracts	5
Hybrid fractional laser treatment for photodamaged facial skin rejuvenation 6 years following fractional CO₂: Comparison of clinical outcome and patients' satisfaction	5
High‐contrast visualization of human skin cancers with combined reflectance confocal and moxifloxacin‐based two‐photon microscopy: An ex vivo study	5
The Effect of Photobiomodulation on Nitrite and Inflammatory Activity in Radiotherapy‐Induced Oral Mucositis: A Randomized Clinical Trial	5
Beneficial Effects of Treatment With Low‐Fluence 755‐nm Q‐Switched Alexandrite Laser for Nevus of Ota	5
Alterted Adipogenesis of Human Mesenchymal Stem Cells by Photobiomodulation Using 1064 nm Laser Light	5
Photobiomodulation with polychromatic light (600–1200 nm) improves fat graft survival by increasing adipocyte viability, neovascularization, and reducing inflammation in a rat model	5
A pilot feasibility study to assess vascularity and perfusion of parathyroid glands using a portable hand‐held imager	5
Theoretical and in vivo investigations of morphology and concentration of gold nanoparticles for laser surgery	5
Effect of Artesunate Combined With Fractional CO₂ Laser on the Hypertrophic Scar in a Rabbit Model	5
Photobiomodulation therapy's effects on cardiac fibrosis activation after experimental myocardial infarction	5
In Vivo Photodynamic Therapy With a Lipophilic Zinc(II) Phthalocyanine Inhibits Colorectal Cancer and Induces a Th1/CD8 Antitumor Immune Response	5

Case Series of Fractional Ablative Laser Resurfacing of Pediatric Facial Traumatic and Surgical Scars	5
Optical Coherence Tomography in the Evaluation of the Scalp and Hair: Common Features and Clinical Utility	5