American Journal of Physiology-Gastrointestinal and Liver Physiology

(The TQCC of American Journal of Physiology-Gastrointestinal and Liver Physiology is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)
The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19117
Effects of dietary components on intestinal permeability in health and disease89
Biomarkers for assessment of intestinal permeability in clinical practice77
Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa66
Understanding chemotherapy-induced intestinal mucositis and strategies to improve gut resilience64
Dynamics of the preterm gut microbiome in health and disease58
Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo55
Exercise and intestinal permeability: another form of exercise-induced hormesis?54
Mitochondrial oxidative injury: a key player in nonalcoholic fatty liver disease51
Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels49
Bile acid metabolism and circadian rhythms48
hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-22344
Interstitial cells of Cajal and human colon motility in health and disease42
The gastric conduction system in health and disease: a translational review42
The role of butyrate in surgical and oncological outcomes in colorectal cancer42
Gut microbiome-based supervised machine learning for clinical diagnosis of inflammatory bowel diseases41
BDNF rescues aging-associated internal anal sphincter dysfunction37
Sarcopenia in chronic liver disease: mechanisms and countermeasures37
The serotonin reuptake transporter is reduced in the epithelium of active Crohn’s disease and ulcerative colitis36
Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity35
Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease35
Early life interaction between the microbiota and the enteric nervous system34
Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure31
A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood31
Ridinilazole, a narrow spectrum antibiotic for treatment of Clostridioides difficile infection, enhances preservation of microbiota-dependent bile acids29
An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase28
Dynamics of the enterohepatic circulation of bile acids in healthy humans27
Visceral myopathy: clinical syndromes, genetics, pathophysiology, and fall of the cytoskeleton26
Brain-gut communication: vagovagal reflexes interconnect the two “brains”26
Modulation of pharyngeal swallowing by bolus volume and viscosity26
Microbiota on biotics: probiotics, prebiotics, and synbiotics to optimize growth and metabolism26
Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans25
Hyperthermia-induced changes in liver physiology and metabolism: a rationale for hyperthermic machine perfusion25
Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels25
Lipid droplets disrupt mechanosensing in human hepatocytes25
Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids24
Spinal neuron-glia-immune interaction in cross-organ sensitization24
The American lifestyle-induced obesity syndrome diet in male and female rodents recapitulates the clinical and transcriptomic features of nonalcoholic fatty liver disease and nonalcoholic steatohepati24
Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice24
Microbial metabolite indole-3-propionic acid supplementation does not protect mice from the cardiometabolic consequences of a Western diet23
Neural control of gut homeostasis23
Bile acid detergency: permeability, inflammation, and effects of sulfation23
Mast cell effects on esophageal smooth muscle and their potential role in eosinophilic esophagitis and achalasia23
Validation of noninvasive body-surface gastric mapping for detecting gastric slow-wave spatiotemporal features by simultaneous serosal mapping in porcine22
Intestinal secretory mechanisms and diarrhea22
Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective21
Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip21
Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling21
Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function21
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model21
Advances in colonic motor complexes in mice21
Noninvasive stratification of nonalcoholic fatty liver disease by whole transcriptome cell-free mRNA characterization21
Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors21
Vitamin D/VDR signaling inhibits colitis by suppressing HIF-1α activation in colonic epithelial cells20
Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis20
Hyaluronic acid promotes Lgr5+ stem cell proliferation and crypt fission through TLR4 and PGE2 transactivation of EGFR20
Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts20
microRNA-382 suppresses the progression of pancreatic cancer through the PI3K/Akt signaling pathway by inhibition of Anxa319
Shifting into high gear: how interstitial cells of Cajal change the motility pattern of the developing intestine19
Obesity and its effects on the esophageal mucosal barrier19
MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury19
Talk about micromanaging! Role of microRNAs in intestinal barrier function19
Role of circadian rhythm and autonomic nervous system in liver function: a hypothetical basis for improving the management of hepatic encephalopathy19
Long noncoding RNA LINC00982 upregulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY118
Bacterial and eukaryotic extracellular vesicles and nonalcoholic fatty liver disease: new players in the gut-liver axis?18
Amygdala microglia modify neuronal plasticity via complement C1q/C3-CR3 signaling and contribute to visceral pain in a rat model18
Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels18
Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites18
Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis17
Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency17
Larazotide acetate: a pharmacological peptide approach to tight junction regulation17
Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice16
Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications16
Gastric accommodation influences proximal gastric and total gastric emptying in concurrent measurements conducted in healthy volunteers16
Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves16
The gut-brain axis: spatial relationship between spinal afferent nerves and 5-HT-containing enterochromaffin cells in mucosa of mouse colon16
Recent advances and health implications of dietary fasting regimens on the gut microbiome16
Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach16
Gastrointestinal organoids: a next-generation tool for modeling human development16
HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia16
Role and mechanisms of exosomal miRNAs in IBD pathophysiology16
Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS316
Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease15
Interleukin-28A induces epithelial barrier dysfunction in CD patient-derived intestinal organoids15
Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments15
GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration15
Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease14
Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice14
Characterization of haustral activity in the human colon14
Simulated stool for assessment of anorectal physiology14
Every breath you take: Impacts of environmental dust exposure on intestinal barrier function–from the gut-lung axis to COVID-1914
Nutritional, pharmacological, and environmental programming of NAFLD in early life14
NRG4-ErbB4 signaling represses proinflammatory macrophage activity14
Cellular origins and lineage relationships of the intestinal epithelium13
Critical appraisal of the mechanisms of gastrointestinal and hepatobiliary infection by COVID-1913
Epigenetic regulation of intestinal stem cell differentiation13
Fecal microbiome and bile acid metabolome in adult short bowel syndrome13
Myostatin in combination with creatine phosphokinase or albumin may differentiate patients with cirrhosis and sarcopenia13
Liver-on-a-chip devices: the pros and cons of complexity13
Cellular maps of gastrointestinal organs: getting the most from tissue clearing13
Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid13
Fungi, host immune response, and tumorigenesis12
Myotomy technique and esophageal contractility impact blown-out myotomy formation in achalasia: an in silico investigation12
Xenobiotic receptors and the regulation of intestinal homeostasis: harnessing the chemical output of the intestinal microbiota12
Microbial metabolites: cause or consequence in gastrointestinal disease?12
Role of an active reserve stem cell subset of enteroendocrine cells in intestinal stem cell dynamics and the genesis of small intestinal neuroendocrine tumors12
Impaired 25-hydroxylation of vitamin D in liver injury suppresses intestinal Paneth cell defensins, leading to gut dysbiosis and liver fibrogenesis12
Hepatic macrophage accumulation with aging: cause for concern?12
Intestinal organoids in coculture: redefining the boundaries of gut mucosa ex vivo modeling12
DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids12
Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer12
The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm12
Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone12
Comprehensive characterization of antral and pyloric contractions by high resolution manometry: applied physiology in suspected gastroparesis12
Involvement of capsaicin-sensitive nerves in the initiation of swallowing evoked by carbonated water in anesthetized rats11
Long-term normothermic machine preservation of human livers: what is needed to succeed?11
Characterization of cytoplasmic lipid droplets in each region of the small intestine of lean and diet-induced obese mice in response to dietary fat11
TNF-α, IL-17, and IL-22 production in the rectal mucosa of nonceliac wheat sensitivity patients: role of adaptive immunity11
Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model11
Gut feelings: the microbiota-gut-brain axis on steroids11
Vitamin D deficiency enhances expression of autophagy-regulating miR-142-3p in mouse and “involved” IBD patient intestinal tissues11
Assessment of the role of FGF15 in mediating the metabolic outcomes of murine vertical sleeve gastrectomy11
Hepatic bile formation: bile acid transport and water flow into the canalicular conduit11
PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling11
Gli2-regulated activation of hepatic stellate cells and liver fibrosis by TGF-β signaling11
Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites11
Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress11
Evidence of enteric angiopathy and neuromuscular hypoxia in patients with mitochondrial neurogastrointestinal encephalomyopathy10
Assessment of esophageal body peristaltic work using functional lumen imaging probe panometry10
Transcriptomic identification of TMIGD1 and its relationship with the ileal epithelial cell differentiation in Crohn’s disease10
Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation10
Yeast β-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models10
Arm lean mass determined by dual-energy X-ray absorptiometry is superior to characterize skeletal muscle and predict sarcopenia-related mortality in cirrhosis10
Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition10
Musings on the wanderer: What’s new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism10
Abnormal intestinal milieu in posttraumatic stress disorder is not impacted by treatment that improves symptoms10
A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice10
Localized gastric distension disrupts slow-wave entrainment leading to temporary ectopic propagation: a high-resolution electrical mapping study10