OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Gastrointestinal and Liver Physiology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia	129
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis	92
Lipidomic signatures discriminate subtle hepatic changes in the progression of porcine nonalcoholic steatohepatitis	63
Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity	61
Regional and conditional variability of FXR: new lessons on ileal inflammation and gut barrier functions	55
Repurposing dried blood spot device technology to examine bile acid profiles in human dried fecal spot samples	53
Animal models with characteristics of irritable bowel syndrome with diarrhea: current applications and future perspectives	49
Functional involvement of the sternohyoid muscle during breathing and swallowing in rats	46
Rhamnogalacturonan promotes intestinal mucosal repair through increased cell migration	45
Effects of potassium on laryngeal-induced swallowing rate in rats	36
P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality	36
Mechanical stress-induced connective tissue growth factor plays a critical role in intestinal fibrosis in Crohn’s-like colitis	35
Cells and mediators of inflammation as effectors of epithelial repair in the inflamed intestine	34
Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice	34
An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics	34
Mechanisms underlying initiation of propulsion in guinea pig distal colon	33
LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice	31
Gut feelings: the microbiota-gut-brain axis on steroids	28
Coordinated signaling of activating transcription factor 6α and inositol-requiring enzyme 1α regulates hepatic stellate cell-mediated fibrogenesis in mice	27
Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity	26
Defecation induced by stimulation of sacral S2 spinal root in cats	26
Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors	26
NH₂-terminal deletion of specific phosphorylation sites on PHOX2B disrupts the formation of enteric neurons in vivo	26
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2	25
Retraction for Wu et al., volume 294, 2008, p. G918–G927	24

Renalase peptides reduce pancreatitis severity in mice	24
A ganglionic intestinointestinal reflex activated by acute noxious challenge	24
Angiotensin receptor blocker alleviates liver fibrosis by altering the mechanotransduction properties of hepatic stellate cells	24
Mass cytometric analysis of circulating monocyte subsets in a murine model of diabetic gastroparesis	23
Effect of ingesting a meal and orthostasis on the regulation of splanchnic and systemic hemodynamics and the responsiveness of cardiovascular α₁-adrenoceptors	23
Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study	22
Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT₃ receptors in the proximal colon	22
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression	22
Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model	22
Characterization of haustral activity in the human colon	22
Contribution of sex hormones to the sexually dimorphic response of colorectal motility to noxious stimuli in rats	22
Arm lean mass determined by dual-energy X-ray absorptiometry is superior to characterize skeletal muscle and predict sarcopenia-related mortality in cirrhosis	21
Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats	21
FOXO3: at the crossroads of metabolic, inflammatory, and tumorigenic remodeling in the colon	20
A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure	20
Who’s talking to whom: microbiome-enteric nervous system interactions in early life	20
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms	20
Is intestinal transport dysfunctional in COVID-19-related diarrhea?	19
Seladelpar combined with complementary therapies improves fibrosis, inflammation, and liver injury in a mouse model of nonalcoholic steatohepatitis	19
Are LRRK2 mysteries lurking in the gut?	19
Blueberry anthocyanins improve liver fibrosis by regulating NCOA4 ubiquitination through TRIM7 to affect ferroptosis of hepatic stellate cells	19
The emerging roles of deep crypt secretory cells in colonic physiology	19
Novel 5-HT₇ receptor antagonists modulate intestinal immune responses and reduce severity of colitis	18
Role of the microbiota-gut-brain axis in postacute COVID syndrome	18
Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress	18
Intestinal ultrasound, an underutilized tool for assessing colonic motility	17
Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency	17
Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis	17
Myostatin in combination with creatine phosphokinase or albumin may differentiate patients with cirrhosis and sarcopenia	17
Ketamine and xylazine effects in murine model of acute pancreatitis	17
Impact of hypoxia and AMPK on CFTR-mediated bicarbonate secretion in human cholangiocyte organoids	17
Gallbladder mucoceles in dogs: a novel form of acquired CFTR dysfunction causing localized cystic fibrosis-like disease	16
Obesogenic cafeteria diet induces dynamic changes in gut microbiota, reduces myenteric neuron excitability, and impairs gut contraction in mice	16
Single-cell analyses of human pancreas: characteristics of two populations of acinar cells in chronic pancreatitis	16
Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions	16
Initiation and severity of experimental pancreatitis are modified by phosphate	16
Tissue- and cell-specific properties of enterochromaffin cells affect the fate of tumorigenesis toward nonendocrine adenocarcinoma of the small intestine	16
Intestinal organoid coculture systems: current approaches, challenges, and future directions	16
Gut Neuropeptide Involvement in Parkinson’s Disease	15
Fecal microbiome and bile acid metabolome in adult short bowel syndrome	15
Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity	15
Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels	15
HOPX⁺ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia	15
Subclinical necrotizing enterocolitis-induced systemic immune suppression in neonatal preterm pigs	15
Intrathecally administered substance P activated the spinal defecation center and enhanced colorectal motility in anesthetized rats	14
Revisiting the gut-liver axis: gut lymphatic system in liver cirrhosis and portal hypertension	14
Inhibited postprandial retrograde cyclic motor pattern in the distal colon of patients with diarrhea-predominant irritable bowel syndrome	14
Corrigendum for Ohno et al., volume 298, 2010, p. G63–G73.	14
Characterization of cytoplasmic lipid droplets in each region of the small intestine of lean and diet-induced obese mice in response to dietary fat	14
ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis	14

Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice	13
Formal degree programs in physiology promote careers of clinical scientists and benefit basic science departments	13
Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments	13
Short-term and long-term effects of unilateral external carotid artery ligation on orofacial functions in rats	13
Cholestenoic acid as endogenous epigenetic regulator decreases hepatocyte lipid accumulation in vitro and in vivo	13
A modular analysis of bile canalicular function and its implications for cholestasis	13
PepT1-knockout mice harbor a protective metabolome beneficial for intestinal wound healing	13
A simple and effective genotyping workflow for rapid detection of CRISPR genome editing	13
Optogenetic activation of the gut-brain axis in freely moving mice using a fully implantable wireless battery-free device	12
Local tissue response to a C-X-C motif chemokine ligand 12 therapy for fecal incontinence in a rabbit model	12
Vitamin D deficiency enhances expression of autophagy-regulating miR-142-3p in mouse and “involved” IBD patient intestinal tissues	12
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function	12
Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease	12
Examining enteric nervous system function in rat and mouse: an interspecies comparison of colonic motility	11
Preferential Neurogenesis of Nitrergic Neurons in the Myenteric Plexus of the DSS-induced Colitis Mouse Colon Causes Colonic Dysmotility in Colitis	11
Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea	11
β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells	11
Exploring the use of panaxynol from American ginseng to combat intestinal inflammation and colon cancer	11
Corrigendum for Liu et al., volume 305, 2013, p. G163–G171	11
Follistatin secretion is enhanced by protein, but not glucose or fat ingestion, in obese persons independently of previous gastric bypass surgery	11
Dynamic functional luminal imaging probe analysis of the anal sphincter opening function during straining in healthy volunteers	11
Hypoosmosis alters hepatocyte mitochondrial morphology and induces selective release of carbamoyl phosphate synthetase 1	11
miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway	10
Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease	10
Gut microbiota of patients insusceptible to olanzapine-induced fatty liver disease relieves hepatic steatosis in rats	10
Deleterious impacts of Western diet on jejunum function and health are reversible	10
Dynamics of the enterohepatic circulation of bile acids in healthy humans	10
Targeting serotonin signaling in the gut to limit colitis via 5-HT₇ receptor antagonism	10
Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons	10
Deacetylation of Notch1 by SIRT1 contributes to HBsAg- and HBeAg-mediated M2 macrophage polarization	10
Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders	10
Early-life fecal microbiome and metabolome dynamics in response to an intervention with infant formula containing specific prebiotics and postbiotics	10
Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats	10
Understanding chemotherapy-induced intestinal mucositis and strategies to improve gut resilience	10
Hope for the gut: new evidence suggests Western diet damage can be undone	10
Deletion of H-ferritin in macrophages mitigates the development of steatohepatitis and hepatocellular carcinoma in mice	9
Inhibition of hedgehog signaling ameliorates severity of chronic pancreatitis in experimental mouse models	9
PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling	9
Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice	9
Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner	9
Retraction for Meng et al. (10.1152/ajpgi.00143.2020)	9
Saturated Phosphatidic Acids Induce mTORC1-Driven Integrated Stress Response Contributing to Glucolipotoxicity in Hepatocytes	9
Feeding intolerance after pediatric cardiac surgery is associated with dysbiosis, barrier dysfunction, and reduced short-chain fatty acids	9
Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine	9
Choline-deficient, high-fat diet-induced MASH in Göttingen Minipigs: characterization and effects of a chow reversal period	9
SGLT2 inhibition leads to a restoration of hepatic and circulating metabolites involved in the folate cycle and pyrimidine biosynthesis	9
Exfoliated epithelial cell transcriptome reflects both small and large intestinal cell signatures in piglets	9
High-energy pacing inhibits slow-wave dysrhythmias in the small intestine	9
Gastrointestinal dysmotility in rodent models of Parkinson’s disease	9
A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts	9
Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy	9
Modeling the kinetics of interorgan arginine metabolism during bacterial sepsis in swine	9
miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells	8
Enhancing the diagnostic yield of esophageal manometry using distension-contraction plots of peristalsis and artificial intelligence	8
NMDA receptor expression during cell transformation process at early stages of liver cancer in rodent models	8
Secretagogue-induced pancreatitis in mice devoid of chymotrypsin	8
Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach	8
Electromechanical coupling and anatomy of the in vivo gastroduodenal junction	8
Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes	8
Th2 cytokine signaling through IL-4Rα increases eotaxin-3 secretion and tension in human esophageal smooth muscle	8
Highlights of how single-cell analyses are illuminating differentiation and disease in the gastric corpus	8
Duodenogastric reflux in health and disease: insights from a computational fluid dynamics model of the stomach	8
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease	8
Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor	8
Gastrointestinal organoids in the study of viral infections	8
A menu for microbes: unraveling appetite regulation and weight dynamics through the microbiota-brain connection across the lifespan	8
Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model	8
Modulation of intracellular calcium activity in interstitial cells of Cajal by inhibitory neural pathways within the internal anal sphincter	8
Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage	8
Hypobaric hypoxia exposure impairs colonic goblet cell subpopulation via the HIF-1α signaling pathway	8
A functional interplay between the two BMP-SMAD pathway inhibitors TMPRSS6 and FKBP12 regulates hepcidin expression in vivo	8
Preclinical applications of high-definition manometry system to investigate pelvic floor muscle contribution to continence mechanisms in a rabbit model	8
Selective inhibition of hepatic stellate cell and fibroblast-derived LOXL1 attenuates BDL- and Mdr2^−/−-induced cholestatic liver fibrosis	8
Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice	8