OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Gastrointestinal and Liver Physiology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia	57
Regional and conditional variability of FXR: new lessons on ileal inflammation and gut barrier functions	51
Lipidomic signatures discriminate subtle hepatic changes in the progression of porcine nonalcoholic steatohepatitis	48
Animal models with characteristics of irritable bowel syndrome with diarrhea: current applications and future perspectives	48
Retraction for Mancinelli et al., volume 297, 2009, G11–G26	40
Corrigendum for Okamura et al., volume 318, 2020, p. G989–G999	38
Repurposing dried blood spot device technology to examine bile acid profiles in human dried fecal spot samples	34
Elevated Circulating Bile Acids Driven Erythrocyte Osmotic Resistance Marks Hepatobiliary Disease	32
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis	30
New approach methodologies in Crohn’s disease link molecular disease subtypes to clinical outcomes	30
Functional involvement of the sternohyoid muscle during breathing and swallowing in rats	29
circRET-mediated regulation of RET influences enteric neural crest cell development in Hirschsprung disease	28
P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality	27
Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity	27
Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice	26
Mechanical stress-induced connective tissue growth factor plays a critical role in intestinal fibrosis in Crohn’s-like colitis	26
An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics	25
Probiotic-mediated regulation of arginine metabolism to improve intestinal barrier function: a metabolic makeover for IBD?	24
Effects of potassium on laryngeal-induced swallowing rate in rats	23
Mechanisms underlying initiation of propulsion in guinea pig distal colon	22
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2	22
Rhamnogalacturonan promotes intestinal mucosal repair through increased cell migration	22
Retraction for Wu et al., volume 294, 2008, p. G918–G927	21
Renalase peptides reduce pancreatitis severity in mice	20
Intestinal permeability responses to maximal and submaximal exercise in individuals with normal-weight obesity: an exploratory study	20

A ganglionic intestinointestinal reflex activated by acute noxious challenge	20
Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity	20
Mass cytometric analysis of circulating monocyte subsets in a murine model of diabetic gastroparesis	19
Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model	19
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression	19
Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats	19
Hysteresis of the lower esophageal sphincter: relevance to the pathogenesis of esophageal achalasia and its phenotypes	19
Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study	18
Novel 5-HT₇ receptor antagonists modulate intestinal immune responses and reduce severity of colitis	18
Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT ₃ receptors in the proximal colon	18
Energy status alters intestinal function and the gut microbiota during consecutive days of high energy demands	18
FOXO3: at the crossroads of metabolic, inflammatory, and tumorigenic remodeling in the colon	17
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms	17
Panaxynol mitigates chemotherapy-induced intestinal mucositis by improving the colonic microenvironment in murine models	16
Are LRRK2 mysteries lurking in the gut?	16
Inhibitory effects of somatostatin on glucagon-like peptide-1-mediated acceleration of peristalsis in the rat proximal colon	16
The emerging roles of deep crypt secretory cells in colonic physiology	16
Seladelpar combined with complementary therapies improves fibrosis, inflammation, and liver injury in a mouse model of nonalcoholic steatohepatitis	15
Role of the microbiota-gut-brain axis in postacute COVID syndrome	15
Is intestinal transport dysfunctional in COVID-19-related diarrhea?	15
Who’s talking to whom: microbiome-enteric nervous system interactions in early life	15
A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure	15
Gallbladder mucoceles in dogs: a novel form of acquired CFTR dysfunction causing localized cystic fibrosis-like disease	14
Intestinal ultrasound, an underutilized tool for assessing colonic motility	14
Gut neuropeptide involvement in Parkinson’s disease	14
Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis	14
Retraction for Marzioni et al., volume 284, 2003, G837–G852	14
Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity	14
Host-microbial interactions in the esophagus	14
Blueberry anthocyanins improve liver fibrosis by regulating NCOA4 ubiquitination through TRIM7 to affect ferroptosis of hepatic stellate cells	14
Tissue- and cell-specific properties of enterochromaffin cells affect the fate of tumorigenesis toward nonendocrine adenocarcinoma of the small intestine	14
Therapeutic zinc targets dysregulated GC-C signaling and restores ileal defects in a preclinical model of familial diarrheal disease	13
Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice	13
Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions	13
Intestinal organoid coculture systems: current approaches, challenges, and future directions	13
A novel gene therapy for ARPKD based on CFTR	12
Role of serine/threonine phosphatases 1 and 2A in pancreatic acinar fluid and electrolyte secretion	12
A simple and effective genotyping workflow for rapid detection of CRISPR genome editing	12
Short-term and long-term effects of unilateral external carotid artery ligation on orofacial functions in rats	12
Farnesoid X receptor inhibits proinflammatory cytokine-induced epithelial necroptosis in vitro: implications for preservation of intestinal barrier function	12
E-cadherin acts as a dynamic switch in epithelial regeneration in inflammatory bowel disease	12
Corrigendum for Lastuvkova et al., 2025, volume 328, p. G558–G577	12
Formal degree programs in physiology promote careers of clinical scientists and benefit basic science departments	12
Inhibited postprandial retrograde cyclic motor pattern in the distal colon of patients with diarrhea-predominant irritable bowel syndrome	12
Obesogenic cafeteria diet induces dynamic changes in gut microbiota, reduces myenteric neuron excitability, and impairs gut contraction in mice	12
Mechanisms of liver regeneration and their relevance to steatotic liver disease	12
Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice	12
HNF4A intestinal ablation positively influences the fate of ileal goblet cells during Salmonella typhimurium infection	11
Optogenetic activation of the gut-brain axis in freely moving mice using a fully implantable wireless battery-free device	11
Temporal transcriptional and functional dynamics of jejunal mucosal response to early weaning in piglets	11

Local tissue response to a C-X-C motif chemokine ligand 12 therapy for fecal incontinence in a rabbit model	11
Cholestenoic acid as endogenous epigenetic regulator decreases hepatocyte lipid accumulation in vitro and in vivo	11
A pilot, randomized, placebo-controlled trial of rimegepant on visceral sensation and symptoms in nonconstipation IBS pain	11
A modular analysis of bile canalicular function and its implications for cholestasis	11
AXL and MERTK in macrophages restore pancreatic exocrine function after severe acute pancreatitis by modulating acinar-to-ductal metaplasia formation	11
Editorial Board	11
Targeting macrophage iron in nonalcoholic steatohepatitis	11
Editorial Board	11
Dynamic functional luminal imaging probe analysis of the anal sphincter opening function during straining in healthy volunteers	10
Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea	10
Gut microbiota of patients insusceptible to olanzapine-induced fatty liver disease relieves hepatic steatosis in rats	10
Reply to Sanders et al.	10
Deleterious impacts of Western diet on jejunum function and health are reversible	10
Preferential neurogenesis of nitrergic neurons in the myenteric plexus of the DSS-induced colitis mouse colon causes colonic dysmotility in colitis	10
Distinct molecular responses of human intestinal organoids to proton and photon radiation	10
Maternal Western diet increases inflammatory markers and decreases barrier function of offspring in Papio anubis	10
Editorial Board	10
Targeting serotonin signaling in the gut to limit colitis via 5-HT₇ receptor antagonism	10
Exploring the use of panaxynol from American ginseng to combat intestinal inflammation and colon cancer	10
Hypoosmosis alters hepatocyte mitochondrial morphology and induces selective release of carbamoyl phosphate synthetase 1	10
β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells	10
Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons	10
Stress during pregnancy alters hepatic renin-angiotensin system and redox homeostasis in a sex- and age-specific manner	10
Editorial Board	10
Examining enteric nervous system function in rat and mouse: an interspecies comparison of colonic motility	10
Hope for the gut: new evidence suggests Western diet damage can be undone	10
Treg-specific IL-6R signaling: a novel role in the regulation of the intestinal epithelium	9
Deletion of H-ferritin in macrophages mitigates the development of steatohepatitis and hepatocellular carcinoma in mice	9
Inhibition of hedgehog signaling ameliorates severity of chronic pancreatitis in experimental mouse models	9
A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts	9
Choline-deficient, high-fat diet-induced MASH in Göttingen Minipigs: characterization and effects of a chow reversal period	9
High-energy pacing inhibits slow-wave dysrhythmias in the small intestine	9
Gut-heart axis: cardiac remodeling and heart failure in the context of inflammatory bowel disease and dysbiosis	9
Saturated phosphatidic acids induce mTORC1-driven integrated stress response contributing to glucolipotoxicity in hepatocytes	9
Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner	9
Unraveling anastomotic leak: biological mechanisms underlying intestinal healing after resection	9
Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease	9
Gastrointestinal dysmotility in rodent models of Parkinson’s disease	9
Dynamic cholangiocyte responses in a murine model of reversible cholestasis: macrophage remodeling and NF-Y-mediated TGFβ1 expression	9
Feeding intolerance after pediatric cardiac surgery is associated with dysbiosis, barrier dysfunction, and reduced short-chain fatty acids	9
SGLT2 inhibition leads to a restoration of hepatic and circulating metabolites involved in the folate cycle and pyrimidine biosynthesis	9
Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice	8
Could physical exercise improve mental health in the context of chronic liver disease?	8
Selective inhibition of hepatic stellate cell and fibroblast-derived LOXL1 attenuates BDL- and Mdr2^−/−-induced cholestatic liver fibrosis	8
Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach	8
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease	8
Electromechanical coupling and anatomy of the in vivo gastroduodenal junction	8
Gastrointestinal organoids in the study of viral infections	8
Lactiplantibacillus plantarum strengthens the intestinal barrier: involvement of the endocannabinoidome	8
Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy	8
Secretagogue-induced pancreatitis in mice devoid of chymotrypsin	8
Editorial Board	8
IP6K1 interacts with the syndecan SDC4 to support secretory granule biogenesis in gastric chief cells	8
Brown adipose tissue inactivation exacerbates alcohol-induced liver steatosis, inflammation, and fibrosis	8
Duodenogastric reflux in health and disease: insights from a computational fluid dynamics model of the stomach	8
Roux-en-Y gastric bypass alters microbial circadian rhythms with links to metabolic improvement	8
Adolescent binge drinking disrupts hepatic lipid homeostasis, leading to steatosis in rats: protective role of folic acid in cholesterol and fatty acid balance	8
Esophageal symptom burden remains high and associates with failed swallows after 5 years in patients with ineffective esophageal motility	8
Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor	8
A functional interplay between the two BMP-SMAD pathway inhibitors TMPRSS6 and FKBP12 regulates hepcidin expression in vivo	8
Therapeutic efficacy, biomarker signatures, and translatability of semaglutide in the liver biopsy-confirmed GAN DIO-MASH mouse model	8
Gut microbiome-mediated nutrients alter opportunistic bacterial growth in peritonitis	8
Modeling the kinetics of interorgan arginine metabolism during bacterial sepsis in swine	8