OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Gastrointestinal and Liver Physiology is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19	114
A story of liver and gut microbes: how does the intestinal flora affect liver disease? A review of the literature	79
Effects of dietary components on intestinal permeability in health and disease	77
Biomarkers for assessment of intestinal permeability in clinical practice	64
Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa	56
Understanding chemotherapy-induced intestinal mucositis and strategies to improve gut resilience	56
Dynamics of the preterm gut microbiome in health and disease	54
Mitochondrial oxidative injury: a key player in nonalcoholic fatty liver disease	49
Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo	49
Exercise and intestinal permeability: another form of exercise-induced hormesis?	47
Bile acid metabolism and circadian rhythms	45
Gut leakage enhances sepsis susceptibility in iron-overloaded β-thalassemia mice through macrophage hyperinflammatory responses	43
hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223	43
Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels	42
The role of butyrate in surgical and oncological outcomes in colorectal cancer	39
The gastric conduction system in health and disease: a translational review	39
Gut microbiome-based supervised machine learning for clinical diagnosis of inflammatory bowel diseases	36
The microbiome-adipose tissue axis in systemic metabolism	36
Interstitial cells of Cajal and human colon motility in health and disease	36
Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization	35
Sarcopenia in chronic liver disease: mechanisms and countermeasures	33
The serotonin reuptake transporter is reduced in the epithelium of active Crohn’s disease and ulcerative colitis	33
Early life interaction between the microbiota and the enteric nervous system	33
Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity	32
On the nature of high-amplitude propagating pressure waves in the human colon	32

BDNF rescues aging-associated internal anal sphincter dysfunction	29
Anti-inflammatory effects of sacral nerve stimulation: a novel spinal afferent and vagal efferent pathway	29
Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease	28
Lipopolysaccharides transport during fat absorption in rodent small intestine	28
Ridinilazole, a narrow spectrum antibiotic for treatment of Clostridioides difficile infection, enhances preservation of microbiota-dependent bile acids	27
A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood	27
Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity	26
Microbiota on biotics: probiotics, prebiotics, and synbiotics to optimize growth and metabolism	26
An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase	26
Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism	26
Hyperthermia-induced changes in liver physiology and metabolism: a rationale for hyperthermic machine perfusion	25
Responses of gut and pancreatic hormones, bile acids, and fibroblast growth factor-21 differ to glucose, protein, and fat ingestion after gastric bypass surgery	25
Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure	25
Visceral myopathy: clinical syndromes, genetics, pathophysiology, and fall of the cytoskeleton	24
Impact of host and environmental factors on β-glucuronidase enzymatic activity: implications for gastrointestinal serotonin	24
Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels	23
Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids	23
Modulation of pharyngeal swallowing by bolus volume and viscosity	23
HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models	23
Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels	22
Microbial metabolite indole-3-propionic acid supplementation does not protect mice from the cardiometabolic consequences of a Western diet	22
Lipid droplets disrupt mechanosensing in human hepatocytes	22
Human intestinal enteroids as a model ofClostridioides difficile-induced enteritis	22
Spinal neuron-glia-immune interaction in cross-organ sensitization	22
Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans	22
Neural control of gut homeostasis	22
Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice	22
The American lifestyle-induced obesity syndrome diet in male and female rodents recapitulates the clinical and transcriptomic features of nonalcoholic fatty liver disease and nonalcoholic steatohepati	21
Advances in colonic motor complexes in mice	21
Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function	21
Brain-gut communication: vagovagal reflexes interconnect the two “brains”	20
Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors	20
Shifting into high gear: how interstitial cells of Cajal change the motility pattern of the developing intestine	19
Dynamics of the enterohepatic circulation of bile acids in healthy humans	19
Validation of noninvasive body-surface gastric mapping for detecting gastric slow-wave spatiotemporal features by simultaneous serosal mapping in porcine	19
Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model	18
miR-524-5p inhibits angiogenesis through targeting WNK1 in colon cancer cells	18
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model	18
Talk about micromanaging! Role of microRNAs in intestinal barrier function	18
Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective	18
Vitamin D/VDR signaling inhibits colitis by suppressing HIF-1α activation in colonic epithelial cells	18
Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts	18
Bile acid detergency: permeability, inflammation, and effects of sulfation	18
Hyaluronic acid promotes Lgr5⁺ stem cell proliferation and crypt fission through TLR4 and PGE₂ transactivation of EGFR	18
Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip	18
MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury	17
microRNA-382 suppresses the progression of pancreatic cancer through the PI3K/Akt signaling pathway by inhibition of Anxa3	17
Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling	17
Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions	17
Obesity and its effects on the esophageal mucosal barrier	17

Noninvasive stratification of nonalcoholic fatty liver disease by whole transcriptome cell-free mRNA characterization	17
Role of circadian rhythm and autonomic nervous system in liver function: a hypothetical basis for improving the management of hepatic encephalopathy	17
Bacterial and eukaryotic extracellular vesicles and nonalcoholic fatty liver disease: new players in the gut-liver axis?	17
Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach	16
Mast cell effects on esophageal smooth muscle and their potential role in eosinophilic esophagitis and achalasia	16
Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel	16
Intestinal epithelial regeneration: active versus reserve stem cells and plasticity mechanisms	16
Organ-specific lymphatics play distinct roles in regulating HDL trafficking and composition	15
ROCK1 inhibitor stabilizes E-cadherin and improves barrier function in experimental necrotizing enterocolitis	15
Role and mechanisms of exosomal miRNAs in IBD pathophysiology	15
Amygdala microglia modify neuronal plasticity via complement C1q/C3-CR3 signaling and contribute to visceral pain in a rat model	15
Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice	15
Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency	15
Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications	15
Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3	15
Bile acid treatment and FXR agonism lower postprandial lipemia in mice	15
Recent advances and health implications of dietary fasting regimens on the gut microbiome	15
Gastrointestinal organoids: a next-generation tool for modeling human development	15
Gastric accommodation influences proximal gastric and total gastric emptying in concurrent measurements conducted in healthy volunteers	14
Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease	14
Numb negatively regulates the epithelial-to-mesenchymal transition in colorectal cancer through the Wnt signaling pathway	14
Larazotide acetate: a pharmacological peptide approach to tight junction regulation	14
Long noncoding RNA LINC00982 upregulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY1	14
Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves	14
Perturbed mitochondrial dynamics, an emerging aspect of epithelial-microbe interactions	14
HOPX⁺ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia	14
Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice	14
Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis	14
Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease	14
Simulated stool for assessment of anorectal physiology	14
Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis	14
Every breath you take: Impacts of environmental dust exposure on intestinal barrier function–from the gut-lung axis to COVID-19	14
Interleukin-28A induces epithelial barrier dysfunction in CD patient-derived intestinal organoids	13
Intestinal secretory mechanisms and diarrhea	13
GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration	13
The gut-brain axis: spatial relationship between spinal afferent nerves and 5-HT-containing enterochromaffin cells in mucosa of mouse colon	13
Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites	13
Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments	12
Cellular maps of gastrointestinal organs: getting the most from tissue clearing	12
Characterization of haustral activity in the human colon	12
Liver-on-a-chip devices: the pros and cons of complexity	12
Fungi, host immune response, and tumorigenesis	12
Myostatin in combination with creatine phosphokinase or albumin may differentiate patients with cirrhosis and sarcopenia	12
Microbial metabolites: cause or consequence in gastrointestinal disease?	12
Fecal microbiome and bile acid metabolome in adult short bowel syndrome	12
Critical appraisal of the mechanisms of gastrointestinal and hepatobiliary infection by COVID-19	12
Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice	12
Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels	11
Xenobiotic receptors and the regulation of intestinal homeostasis: harnessing the chemical output of the intestinal microbiota	11
Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model	11
Cellular origins and lineage relationships of the intestinal epithelium	11
Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid	11
Epigenetic regulation of intestinal stem cell differentiation	11
Role of an active reserve stem cell subset of enteroendocrine cells in intestinal stem cell dynamics and the genesis of small intestinal neuroendocrine tumors	11
NRG4-ErbB4 signaling represses proinflammatory macrophage activity	11
Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone	11
Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice	11
Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation	10
Impaired 25-hydroxylation of vitamin D in liver injury suppresses intestinal Paneth cell defensins, leading to gut dysbiosis and liver fibrogenesis	10
The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm	10
Gli2-regulated activation of hepatic stellate cells and liver fibrosis by TGF-β signaling	10
Long-term normothermic machine preservation of human livers: what is needed to succeed?	10
Characterization of cytoplasmic lipid droplets in each region of the small intestine of lean and diet-induced obese mice in response to dietary fat	10
Nutritional, pharmacological, and environmental programming of NAFLD in early life	10
PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling	10
A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice	10
Musings on the wanderer: What’s new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism	10
Hepatic bile formation: bile acid transport and water flow into the canalicular conduit	10
Involvement of capsaicin-sensitive nerves in the initiation of swallowing evoked by carbonated water in anesthetized rats	10
Intestinal organoids in coculture: redefining the boundaries of gut mucosa ex vivo modeling	10