OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Gastrointestinal and Liver Physiology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
The transgenic BAC-Alb-FlpO mouse line: a new tool for liver disease research	96
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis	77
Rhamnogalacturonan promotes intestinal mucosal repair through increased cell migration	71
Diet-Microbiome-ENS connection: Impact of the Cafeteria Diet	70
Repurposing dried blood spot device technology to examine bile acid profiles in human dried fecal spot samples	58
Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling	54
Stress-induced neuroplasticity in the gastric response to brainstem oxytocin in male rats	48
Lipidomic signatures discriminate subtle hepatic changes in the progression of porcine nonalcoholic steatohepatitis	47
PepT1-knockout mice harbor a protective metabolome beneficial for intestinal wound healing	45
Fatigability of the external anal sphincter muscles using a novel strength training resistance exercise device	45
Cells and mediators of inflammation as effectors of epithelial repair in the inflamed intestine	45
Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice	45
Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway	38
Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology	38
Impaired nitrergic relaxation in pyloric sphincter of the 6-OHDA Parkinson’s disease rat	31
Glutamatergic plasticity within neurocircuits of the dorsal vagal complex and the regulation of gastric functions	28
Validation of noninvasive body-surface gastric mapping for detecting gastric slow-wave spatiotemporal features by simultaneous serosal mapping in porcine	28
Bacterial and eukaryotic extracellular vesicles and nonalcoholic fatty liver disease: new players in the gut-liver axis?	28
Postprandial symptoms in patients with symptoms of gastroparesis: roles of gastric emptying and accommodation	27
An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics	27
Propionibacterium freudenreichii CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening	26
Short-term and long-term effects of unilateral external carotid artery ligation on orofacial functions in rats	25
Hepatic progesterone receptor membrane component 1 attenuates ethanol-induced liver injury by reducing acetaldehyde production and oxidative stress	25
Amniotic fluid modifies esophageal epithelium differentiation and inflammatory responses	24
Gut reactions: emerging mechanisms of abdominal pain from food intake	24

Regional and conditional variability of FXR: new lessons on ileal inflammation and gut barrier functions	24
Intraduodenal fecal microbiota transplantation ameliorates gut atrophy and cholestasis in a novel parenteral nutrition piglet model	23
Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity	23
Investigating Helicobacter pylori-related pyloric hypomotility: functional, histological, and molecular alterations	22
Mind-body connection: metabolite 4-ethylphenyl linked to anxiety behavior and oligodendrocyte modification in autism spectrum disorder	22
Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway	22
Spatial transcriptomics add a new dimension to our understanding of the gut	22
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization	21
Vitamin D deficiency enhances expression of autophagy-regulating miR-142-3p in mouse and “involved” IBD patient intestinal tissues	20
Plant green pigment of chlorophyllin attenuates inflammatory bowel diseases by suppressing autophagy activation in mice	20
Intestinal extracellular vesicles are altered by vertical sleeve gastrectomy	20
Nrf2 expression in pancreatic stellate cells promotes progression of cancer	20
Mice carrying an epithelial deletion of the glucocorticoid receptor NR3C1 develop a higher tumor load in experimental colitis-associated cancer	20
Improving morphological and functional properties of enteric neuronal networks in vitro using a novel upside-down culture approach	19
Hepatic LGR4 aggravates cholestasis-induced liver injury in mice	19
Enteric nervous system as a target and source of SARS-CoV-2 and other viral infections	19
Construction and validation of a rat model of acute necrotizing pancreatitis-associated intestinal injury	19
A simple and effective genotyping workflow for rapid detection of CRISPR genome editing	19
Formal degree programs in physiology promote careers of clinical scientists and benefit basic science departments	18
Will the EGG finally hatch?	18
Hepatic bile acid accretion correlates with cholestatic liver injury and therapeutic response in Cyp2c70 knockout mice with a humanized bile acid composition	18
Developmental maturation of the colonic uptake process of the microbiota-generated thiamin pyrophosphate	18
Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease	18
Localized gastric distension disrupts slow-wave entrainment leading to temporary ectopic propagation: a high-resolution electrical mapping study	18
Dietary fiber intake and fecal short-chain fatty acid concentrations are associated with lower plasma lipopolysaccharide-binding protein and inflammation	17
Developmental alterations of intestinal SGLT1 and GLUT2 induced by early weaning coincides with persistent low-grade metabolic inflammation in female pigs	17
Visceral myopathy: clinical syndromes, genetics, pathophysiology, and fall of the cytoskeleton	17
Obesity and its effects on the esophageal mucosal barrier	17
Functional involvement of the sternohyoid muscle during breathing and swallowing in rats	17
Parenteral lipid emulsions induce unique ileal fatty acid and metabolomic profiles but do not increase the risk of necrotizing enterocolitis in preterm pigs	17
Mechanical stress-induced connective tissue growth factor plays a critical role in intestinal fibrosis in Crohn’s-like colitis	16
Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia	16
Comprehensive characterization of antral and pyloric contractions by high resolution manometry: applied physiology in suspected gastroparesis	16
Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo	15
Animal models with characteristics of irritable bowel syndrome with diarrhea: current applications and future perspectives	15
Duodenal and proximal jejunal motility inhibition associated with bisacodyl-induced colonic high-amplitude propagating contractions	15
Bile acid detergency: permeability, inflammation, and effects of sulfation	15
P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality	15
Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis	15
Intestinal organoids in coculture: redefining the boundaries of gut mucosa ex vivo modeling	15
Inhibition of visceral adipose tissue-derived pathogenic signals by activation of adenosine A_2AR improves hepatic and cardiac dysfunction of NASH mice	15
Long-term normothermic machine preservation of human livers: what is needed to succeed?	14
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function	14
A modular analysis of bile canalicular function and its implications for cholestasis	14
Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice	14
Amygdala microglia modify neuronal plasticity via complement C1q/C3-CR3 signaling and contribute to visceral pain in a rat model	14
Cholestenoic acid as endogenous epigenetic regulator decreases hepatocyte lipid accumulation in vitro and in vivo	14
Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure	13
Retraction for Meng M et al., CLIC1 facilitates cancer associated fibroblast activation and gastric cancer progression via integrins/NF-κB pathway	13
GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration	13

Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels	13
Corrigendum for Cosme et al., volume 323, 2022, p. G410–G419	13
Increased suicidal erythrocyte death in patients with hepatitis B-related acute-on-chronic liver failure	13
Control of colonic motility using electrical stimulation to modulate enteric neural activity	13
Retraction for Wei et al., Electroacupuncture stimulation at Yanglingquan acupoint ameliorates hepatic ischemia-reperfusion injury by down-regulating ET-1 to inhibit TAK1-JNK/p38 pathway	13
Retraction for Glaser et al., volume 295, 2008, G124–G136	13
Nicotinic stimulation of splenic T cells is protective in endoscopic retrograde cholangiopancreatography-induced acute pancreatitis in mice	12
Examining enteric nervous system function in rat and mouse: an interspecies comparison of colonic motility	12
Local tissue response to a C-X-C motif chemokine ligand 12 therapy for fecal incontinence in a rabbit model.	12
Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids	12
Alterations in gene expression and microbiome composition upon calcium-sensing receptor deletion in the mouse esophagus	12
Pharyngoesophageal motility reflex mechanisms in the human neonate: importance of integrative cross-systems physiology	11
Colonic mucosal microbiota is associated with bowel habit subtype and abdominal pain in patients with irritable bowel syndrome	11
Interleukin-28A induces epithelial barrier dysfunction in CD patient-derived intestinal organoids	11
Liver X receptor β regulates bile volume and the expression of aquaporins and cystic fibrosis transmembrane conductance regulator in the gallbladder	11
Novel insights into physiological mechanisms underlying fecal continence	11
Feeding medium-chain fatty acid-rich formula causes liver steatosis and alters hepatic metabolism in neonatal pigs	11
Altered hepatic and intestinal homeostasis in a neonatal murine model of short-term total parenteral nutrition and antibiotics	11
Spatial response of jejunal pacing defined by a novel high-resolution multielectrode array	11
Eosinophil-associated microinflammation in the gastroduodenal tract contributes to gastric hypersensitivity in a rat model of early-life adversity	11
Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa	11
Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis	10
Forkhead box M1 mediates metabolic reprogramming in human colorectal cancer cells	10
Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease	10
Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton	10
Deacetylation of Notch1 by SIRT1 contributes to HBsAg- and HBeAg-mediated M2 macrophage polarization	10
Estimation of mechanical work done to open the esophagogastric junction using functional lumen imaging probe panometry	10
GSK3β/NF-κB -dependent transcriptional regulation of homeostatic hepatocyte Tnf production	10
Maternal obesogenic diet regulates offspring bile acid homeostasis and hepatic lipid metabolism via the gut microbiome in mice	10
Differential sensitivity to Wnt signaling gradients in human gastric organoids derived from corpus and antrum	10
Follistatin secretion is enhanced by protein, but not glucose or fat ingestion, in obese persons independently of previous gastric bypass surgery	10
Absorption of nonheme iron during gastric acid suppression in patients with hereditary hemochromatosis and healthy controls	9
MicroRNA dysregulation and therapeutic opportunities in esophageal diseases	9
Deleterious impacts of Western diet on jejunum function and health are reversible	9
Neuronal innervation of the intestinal crypt	9
Coordinated signaling of activating transcription factor 6α and inositol-requiring enzyme 1α regulates hepatic stellate cell-mediated fibrogenesis in mice	9
Mechanisms underlying initiation of propulsion in guinea pig distal colon	9
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon	9
β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells	9
A systems-level analysis of bile acids effects on rat colon epithelial cells	9
Prenatal Lipopolysaccharide Stimulation Modulates Gastrointestinal Immunity and Oxidative Status in Weaned Pigs	9
A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice	9
Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer	9
Circular RNA RRM2 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miR-142-5p to increase NRG1 expression	9
NH₂-terminal deletion of specific phosphorylation sites on PHOX2B disrupts the formation of enteric neurons in vivo	9
Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors	9
Bile acid sequestrant inhibits gluconeogenesis via inducing hepatic cysteine dioxygenase type 1 to reduce cysteine availability	9
Gut microbiota of patients insusceptible to olanzapine-induced fatty liver disease relieves hepatic steatosis in rats	9
Impaired sliding between the lower esophageal sphincter and crural diaphragm (esophageal hiatus) in patients with achalasia esophagus	9
Intestinal dysmotility after bowel resection in rats is associated with decreased ghrelin and vimentin expression and loss of intestinal cells of Cajal	9
Hypoosmosis alters hepatocyte mitochondrial morphology and induces selective release of carbamoyl phosphate synthetase 1	8
Gut feelings: the microbiota-gut-brain axis on steroids	8
Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats	8
A ganglionic intestinointestinal reflex activated by acute noxious challenge	8
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2	8
Single-day and multi-day exposure to orogastric gavages does not affect intestinal barrier function in mice	8
Stromal DLK1 promotes proliferation and inhibits differentiation of the intestinal epithelium during development	8
Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea	8
Medium-chain fatty acid oxidation is independent of l-carnitine in liver and kidney but not in heart and skeletal muscle	8
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2	8