OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Gastrointestinal and Liver Physiology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia	63
Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity	44
Repurposing dried blood spot device technology to examine bile acid profiles in human dried fecal spot samples	40
Retraction for Mancinelli et al., volume 297, 2009, G11–G26	38
Mechanical stress-induced connective tissue growth factor plays a critical role in intestinal fibrosis in Crohn’s-like colitis	34
Effects of potassium on laryngeal-induced swallowing rate in rats	33
Rhamnogalacturonan promotes intestinal mucosal repair through increased cell migration	32
Functional involvement of the sternohyoid muscle during breathing and swallowing in rats	31
Regional and conditional variability of FXR: new lessons on ileal inflammation and gut barrier functions	31
Lipidomic signatures discriminate subtle hepatic changes in the progression of porcine nonalcoholic steatohepatitis	29
Probiotic-mediated regulation of arginine metabolism to improve intestinal barrier function: a metabolic makeover for IBD?	27
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis	26
An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics	25
Animal models with characteristics of irritable bowel syndrome with diarrhea: current applications and future perspectives	25
Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice	25
Cells and mediators of inflammation as effectors of epithelial repair in the inflamed intestine	25
P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality	24
Mechanisms underlying initiation of propulsion in guinea pig distal colon	24
Retraction for Wu et al., volume 294, 2008, p. G918–G927	24
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2	23
Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity	22
Renalase peptides reduce pancreatitis severity in mice	22
Angiotensin receptor blocker alleviates liver fibrosis by altering the mechanotransduction properties of hepatic stellate cells	22
LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice	22
A ganglionic intestinointestinal reflex activated by acute noxious challenge	22

Gut feelings: the microbiota-gut-brain axis on steroids	21
Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT₃ receptors in the proximal colon	20
Mass cytometric analysis of circulating monocyte subsets in a murine model of diabetic gastroparesis	20
Defecation induced by stimulation of sacral S2 spinal root in cats	20
Energy status alters intestinal function and the gut microbiota during consecutive days of high energy demands	18
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression	18
Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study	18
Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model	18
Hysteresis of the lower esophageal sphincter: relevance to the pathogenesis of esophageal achalasia and its phenotypes	18
Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats	18
Contribution of sex hormones to the sexually dimorphic response of colorectal motility to noxious stimuli in rats	18
Host-microbial interactions in the esophagus	17
Is intestinal transport dysfunctional in COVID-19-related diarrhea?	17
Who’s talking to whom: microbiome-enteric nervous system interactions in early life	17
Seladelpar combined with complementary therapies improves fibrosis, inflammation, and liver injury in a mouse model of nonalcoholic steatohepatitis	16
Role of the microbiota-gut-brain axis in postacute COVID syndrome	16
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms	16
FOXO3: at the crossroads of metabolic, inflammatory, and tumorigenic remodeling in the colon	16
Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis	16
Blueberry anthocyanins improve liver fibrosis by regulating NCOA4 ubiquitination through TRIM7 to affect ferroptosis of hepatic stellate cells	15
The emerging roles of deep crypt secretory cells in colonic physiology	15
Novel 5-HT₇ receptor antagonists modulate intestinal immune responses and reduce severity of colitis	15
A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure	15
Tissue- and cell-specific properties of enterochromaffin cells affect the fate of tumorigenesis toward nonendocrine adenocarcinoma of the small intestine	15
Are LRRK2 mysteries lurking in the gut?	15
Gallbladder mucoceles in dogs: a novel form of acquired CFTR dysfunction causing localized cystic fibrosis-like disease	14
Intestinal ultrasound, an underutilized tool for assessing colonic motility	14
Gut neuropeptide involvement in Parkinson’s disease	13
Fecal microbiome and bile acid metabolome in adult short bowel syndrome	13
Retraction for Marzioni et al., volume 284, 2003, G837–G852	13
A novel gene therapy for ARPKD based on CFTR	13
Farnesoid X receptor inhibits proinflammatory cytokine-induced epithelial necroptosis in vitro: implications for preservation of intestinal barrier function	13
Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice	13
Intestinal organoid coculture systems: current approaches, challenges, and future directions	13
Obesogenic cafeteria diet induces dynamic changes in gut microbiota, reduces myenteric neuron excitability, and impairs gut contraction in mice	12
Initiation and severity of experimental pancreatitis are modified by phosphate	12
Revisiting the gut-liver axis: gut lymphatic system in liver cirrhosis and portal hypertension	12
Formal degree programs in physiology promote careers of clinical scientists and benefit basic science departments	12
Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice	12
Mechanisms of liver regeneration and their relevance to steatotic liver disease	12
Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity	12
Corrigendum for Ohno et al., volume 298, 2010, p. G63–G73.	12
ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis	12
A simple and effective genotyping workflow for rapid detection of CRISPR genome editing	12
Dynamic functional luminal imaging probe analysis of the anal sphincter opening function during straining in healthy volunteers	12
Intrathecally administered substance P activated the spinal defecation center and enhanced colorectal motility in anesthetized rats	12
Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions	12
Inhibited postprandial retrograde cyclic motor pattern in the distal colon of patients with diarrhea-predominant irritable bowel syndrome	12
A modular analysis of bile canalicular function and its implications for cholestasis	12
Local tissue response to a C-X-C motif chemokine ligand 12 therapy for fecal incontinence in a rabbit model	12

Corrigendum for Lastuvkova et al., 2025, volume 328, p. G558–G577	12
Distinct molecular responses of human intestinal organoids to proton and photon radiation	11
β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells	11
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function	11
Cholestenoic acid as endogenous epigenetic regulator decreases hepatocyte lipid accumulation in vitro and in vivo	11
Temporal transcriptional and functional dynamics of jejunal mucosal response to early weaning in piglets	11
Targeting Macrophage Iron in Nonalcoholic Steatohepatitis (NASH)	11
Optogenetic activation of the gut-brain axis in freely moving mice using a fully implantable wireless battery-free device	11
Short-term and long-term effects of unilateral external carotid artery ligation on orofacial functions in rats	11
Corrigendum for Liu et al., volume 305, 2013, p. G163–G171	10
Exploring the use of panaxynol from American ginseng to combat intestinal inflammation and colon cancer	10
Stress during pregnancy alters hepatic renin-angiotensin system and redox homeostasis in a sex- and age-specific manner	10
Hope for the gut: new evidence suggests Western diet damage can be undone	10
Deleterious impacts of Western diet on jejunum function and health are reversible	10
Preferential neurogenesis of nitrergic neurons in the myenteric plexus of the DSS-induced colitis mouse colon causes colonic dysmotility in colitis	10
Examining enteric nervous system function in rat and mouse: an interspecies comparison of colonic motility	10
Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea	10
Gut microbiota of patients insusceptible to olanzapine-induced fatty liver disease relieves hepatic steatosis in rats	10
Maternal Western diet increases inflammatory markers and decreases barrier function of offspring in Papio anubis	10
Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats	10
Hypoosmosis alters hepatocyte mitochondrial morphology and induces selective release of carbamoyl phosphate synthetase 1	9
Targeting serotonin signaling in the gut to limit colitis via 5-HT₇ receptor antagonism	9
Feeding intolerance after pediatric cardiac surgery is associated with dysbiosis, barrier dysfunction, and reduced short-chain fatty acids	9
Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine	9
Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons	9
High-energy pacing inhibits slow-wave dysrhythmias in the small intestine	9
Gastrointestinal dysmotility in rodent models of Parkinson’s disease	9
Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders	9
Gut-heart axis: cardiac remodeling and heart failure in the context of inflammatory bowel disease and dysbiosis	9
Deacetylation of Notch1 by SIRT1 contributes to HBsAg- and HBeAg-mediated M2 macrophage polarization	9
Saturated phosphatidic acids induce mTORC1-driven integrated stress response contributing to glucolipotoxicity in hepatocytes	9
Inhibition of hedgehog signaling ameliorates severity of chronic pancreatitis in experimental mouse models	9
Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease	9
Dynamic cholangiocyte responses in a murine model of reversible cholestasis: macrophage remodeling and NF-Y-mediated TGFβ1 expression	9
Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner	8
Modeling the kinetics of interorgan arginine metabolism during bacterial sepsis in swine	8
Choline-deficient, high-fat diet-induced MASH in Göttingen Minipigs: characterization and effects of a chow reversal period	8
Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy	8
Deletion of H-ferritin in macrophages mitigates the development of steatohepatitis and hepatocellular carcinoma in mice	8
Early-life fecal microbiome and metabolome dynamics in response to an intervention with infant formula containing specific prebiotics and postbiotics	8
Adolescent binge drinking disrupts hepatic lipid homeostasis, leading to steatosis in rats: protective role of folic acid in cholesterol and fatty acid balance	8
Secretagogue-induced pancreatitis in mice devoid of chymotrypsin	8
Lactiplantibacillus plantarum strengthens the intestinal barrier: involvement of the endocannabinoidome	8
A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts	8
SGLT2 inhibition leads to a restoration of hepatic and circulating metabolites involved in the folate cycle and pyrimidine biosynthesis	8
Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice	8
Preclinical applications of high-definition manometry system to investigate pelvic floor muscle contribution to continence mechanisms in a rabbit model	8
Treg-specific IL-6R signaling: a novel role in the regulation of the intestinal epithelium	8
Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage	7
Electromechanical coupling and anatomy of the in vivo gastroduodenal junction	7
Selective inhibition of hepatic stellate cell and fibroblast-derived LOXL1 attenuates BDL- and Mdr2^−/−-induced cholestatic liver fibrosis	7
Gut microbiome-mediated nutrients alter opportunistic bacterial growth in peritonitis	7
Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach	7
Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model	7
Gastrointestinal organoids in the study of viral infections	7
Editorial Board	7
NMDA receptor expression during cell transformation process at early stages of liver cancer in rodent models	7
Could physical exercise improve mental health in the context of chronic liver disease?	7
A menu for microbes: unraveling appetite regulation and weight dynamics through the microbiota-brain connection across the lifespan	7
Hepatic protein kinase Cβ antagonizing p38 ^MAPK to activate ERK1/2 to dysregulate biliary lipid composition upon lithogenic stress	7
Th2 cytokine signaling through IL-4Rα increases eotaxin-3 secretion and tension in human esophageal smooth muscle	7
This is not your off-the-shelf IPA	7
A functional interplay between the two BMP-SMAD pathway inhibitors TMPRSS6 and FKBP12 regulates hepcidin expression in vivo	7
Hypobaric hypoxia exposure impairs colonic goblet cell subpopulation via the HIF-1α signaling pathway	7
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease	7
Duodenogastric reflux in health and disease: insights from a computational fluid dynamics model of the stomach	7
Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor	7
Highlights of how single-cell analyses are illuminating differentiation and disease in the gastric corpus	7
Liquid nutrient drink testing induces gastric myoelectrical abnormalities that correlate with gastroduodenal symptoms	7