OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Gastrointestinal and Liver Physiology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Effects of dietary components on intestinal permeability in health and disease	100
Biomarkers for assessment of intestinal permeability in clinical practice	88
Understanding chemotherapy-induced intestinal mucositis and strategies to improve gut resilience	71
Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa	71
Dynamics of the preterm gut microbiome in health and disease	63
Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo	58
Bile acid metabolism and circadian rhythms	51
Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels	50
Interstitial cells of Cajal and human colon motility in health and disease	45
The role of butyrate in surgical and oncological outcomes in colorectal cancer	45
The gastric conduction system in health and disease: a translational review	45
Gut microbiome-based supervised machine learning for clinical diagnosis of inflammatory bowel diseases	44
hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223	44
Sarcopenia in chronic liver disease: mechanisms and countermeasures	40
Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure	39
BDNF rescues aging-associated internal anal sphincter dysfunction	38
Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity	38
Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease	37
The serotonin reuptake transporter is reduced in the epithelium of active Crohn’s disease and ulcerative colitis	37
Early life interaction between the microbiota and the enteric nervous system	34
Modulation of pharyngeal swallowing by bolus volume and viscosity	28
Dynamics of the enterohepatic circulation of bile acids in healthy humans	28
Visceral myopathy: clinical syndromes, genetics, pathophysiology, and fall of the cytoskeleton	28
Brain-gut communication: vagovagal reflexes interconnect the two “brains”	28
Spinal neuron-glia-immune interaction in cross-organ sensitization	27

Bile acid detergency: permeability, inflammation, and effects of sulfation	27
Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice	26
Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans	25
Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels	25
Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids	25
Mast cell effects on esophageal smooth muscle and their potential role in eosinophilic esophagitis and achalasia	25
Intestinal secretory mechanisms and diarrhea	25
Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts	24
Validation of noninvasive body-surface gastric mapping for detecting gastric slow-wave spatiotemporal features by simultaneous serosal mapping in porcine	24
Neural control of gut homeostasis	24
Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling	24
Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip	23
Noninvasive stratification of nonalcoholic fatty liver disease by whole transcriptome cell-free mRNA characterization	23
Advances in colonic motor complexes in mice	23
Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis	23
Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective	22
Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors	22
MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury	22
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model	22
Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function	21
Amygdala microglia modify neuronal plasticity via complement C1q/C3-CR3 signaling and contribute to visceral pain in a rat model	20
Larazotide acetate: a pharmacological peptide approach to tight junction regulation	20
Obesity and its effects on the esophageal mucosal barrier	20
Role of circadian rhythm and autonomic nervous system in liver function: a hypothetical basis for improving the management of hepatic encephalopathy	20
The gut-brain axis: spatial relationship between spinal afferent nerves and 5-HT-containing enterochromaffin cells in mucosa of mouse colon	19
Liver-on-a-chip devices: the pros and cons of complexity	19
Long noncoding RNA LINC00982 upregulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY1	19
Vitamin D/VDR signaling inhibits colitis by suppressing HIF-1α activation in colonic epithelial cells	19
Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis	18
Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach	18
Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice	18
Bacterial and eukaryotic extracellular vesicles and nonalcoholic fatty liver disease: new players in the gut-liver axis?	18
Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels	18
Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency	18
HOPX⁺ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia	17
Role and mechanisms of exosomal miRNAs in IBD pathophysiology	17
Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice	17
Gastric accommodation influences proximal gastric and total gastric emptying in concurrent measurements conducted in healthy volunteers	17
Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications	17
Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3	16
Cellular origins and lineage relationships of the intestinal epithelium	16
Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease	16
Recent advances and health implications of dietary fasting regimens on the gut microbiome	16
GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration	16
Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments	15
Myostatin in combination with creatine phosphokinase or albumin may differentiate patients with cirrhosis and sarcopenia	15
Interleukin-28A induces epithelial barrier dysfunction in CD patient-derived intestinal organoids	15
DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids	15
Every breath you take: Impacts of environmental dust exposure on intestinal barrier function–from the gut-lung axis to COVID-19	15
Nutritional, pharmacological, and environmental programming of NAFLD in early life	15

Microbial metabolites: cause or consequence in gastrointestinal disease?	15
The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm	14
Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease	14
Impaired 25-hydroxylation of vitamin D in liver injury suppresses intestinal Paneth cell defensins, leading to gut dysbiosis and liver fibrogenesis	14
Characterization of haustral activity in the human colon	14
Intestinal organoids in coculture: redefining the boundaries of gut mucosa ex vivo modeling	14
Fecal microbiome and bile acid metabolome in adult short bowel syndrome	14
NRG4-ErbB4 signaling represses proinflammatory macrophage activity	14
Comprehensive characterization of antral and pyloric contractions by high resolution manometry: applied physiology in suspected gastroparesis	14
Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition	13
Myotomy technique and esophageal contractility impact blown-out myotomy formation in achalasia: an in silico investigation	13
Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid	13
Severe acute pancreatitis exhibits distinct cytokine signatures and trajectories in humans: a prospective observational study	13
Characterization of cytoplasmic lipid droplets in each region of the small intestine of lean and diet-induced obese mice in response to dietary fat	13
Assessment of the role of FGF15 in mediating the metabolic outcomes of murine vertical sleeve gastrectomy	13
Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model	13
Long-term normothermic machine preservation of human livers: what is needed to succeed?	13
Fungi, host immune response, and tumorigenesis	13
Critical appraisal of the mechanisms of gastrointestinal and hepatobiliary infection by COVID-19	13
Involvement of capsaicin-sensitive nerves in the initiation of swallowing evoked by carbonated water in anesthetized rats	13
Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites	12
Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress	12
PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling	12
Abnormal intestinal milieu in posttraumatic stress disorder is not impacted by treatment that improves symptoms	12
Hepatic macrophage accumulation with aging: cause for concern?	12
Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer	12
Yeast β-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models	12
Xenobiotic receptors and the regulation of intestinal homeostasis: harnessing the chemical output of the intestinal microbiota	12
Musings on the wanderer: What’s new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism	11
Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, an	11
Localized gastric distension disrupts slow-wave entrainment leading to temporary ectopic propagation: a high-resolution electrical mapping study	11
Revisiting the gut-liver axis: gut lymphatic system in liver cirrhosis and portal hypertension	11
Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation	11
Gli2-regulated activation of hepatic stellate cells and liver fibrosis by TGF-β signaling	11
Vitamin D deficiency enhances expression of autophagy-regulating miR-142-3p in mouse and “involved” IBD patient intestinal tissues	11
Evidence of enteric angiopathy and neuromuscular hypoxia in patients with mitochondrial neurogastrointestinal encephalomyopathy	11
Hepatic bile formation: bile acid transport and water flow into the canalicular conduit	11
Gut feelings: the microbiota-gut-brain axis on steroids	11
GLUT5 is a determinant of dietary fructose-mediated exacerbation of experimental colitis	10
Relationship of motor mechanisms to gastroparesis symptoms: toward individualized treatment	10
A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice	10
Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation	10
Simultaneous whole-cell patch-clamp and calcium imaging on myenteric neurons	10
Assessment of esophageal body peristaltic work using functional lumen imaging probe panometry	10
The potent and selective RIPK2 inhibitor BI 706039 improves intestinal inflammation in the TRUC mouse model of inflammatory bowel disease	10
Pyloric distensibility in health and disease	10
Hepatoprotective effects of the long-acting fibroblast growth factor 21 analog PF-05231023 in the GAN diet-induced obese and biopsy-confirmed mouse model of nonalcoholic steatohepatitis	10
Arm lean mass determined by dual-energy X-ray absorptiometry is superior to characterize skeletal muscle and predict sarcopenia-related mortality in cirrhosis	10
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function	10
Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes	9
Endoscopic ultrasound-guided sampling and profiling of portal circulation in human patients for metabolic research studies and biomarker assessment	9
Urolithin A attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling	9
Inflammatory bowel disease therapeutic strategies by modulation of the microbiota: how and when to introduce pre-, pro-, syn-, or postbiotics?	9
Probiotics, prebiotics, and synbiotics in nonalcoholic fatty liver disease and alcohol-associated liver disease	9
Maternal obesogenic diet regulates offspring bile acid homeostasis and hepatic lipid metabolism via the gut microbiome in mice	9
Postprandial symptoms in patients with symptoms of gastroparesis: roles of gastric emptying and accommodation	9
Melatonin ameliorates aging-related impaired angiogenesis in gastric endothelial cells via local actions on mitochondria and VEGF-survivin signaling	9
LINC00511-dependent inhibition of IL-24 contributes to the oncogenic role of HNF4α in colorectal cancer	9
Pregnancy-related plasticity of gastric vagal afferent signals in mice	9
A human Barrett’s esophagus organoid system reveals epithelial-mesenchymal plasticity induced by acid and bile salts	9
LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice	9
Deacetylation of Notch1 by SIRT1 contributes to HBsAg- and HBeAg-mediated M2 macrophage polarization	9
ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis	9
Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s)	9
Cross talk between the gut microbiome and host immune response in ulcerative colitis: nonpharmacological strategies to improve homeostasis	9
Effects of remifentanil on pharyngeal swallowing and esophageal motility: no impact of different bolus volumes and partial antagonism by methylnaltrexone	9
miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway	9
Angiotensin receptor blocker alleviates liver fibrosis by altering the mechanotransduction properties of hepatic stellate cells	9
Nrf2 expression in pancreatic stellate cells promotes progression of cancer	9