American Journal of Physiology-Endocrinology and Metabolism

(The TQCC of American Journal of Physiology-Endocrinology and Metabolism is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-06-01 to 2023-06-01.)
Lipoprotein lipase: from gene to obesity555
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise380
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans300
Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice284
Essential amino acids and muscle protein recovery from resistance exercise270
IL-6 and TNF-α expression in, and release from, contracting human skeletal muscle265
Assessment of β-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests242
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress184
DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells176
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity170
Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis168
Postexercise net protein synthesis in human muscle from orally administered amino acids158
Effect of high-intensity intermittent training on lactate and H+ release from human skeletal muscle155
Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT147
Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo140
Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training133
Minimal model estimation of glucose absorption and insulin sensitivity from oral test: validation with a tracer method133
Dietary iron restriction or iron chelation protects from diabetes and loss of β-cell function in the obese (ob/ob lep−/−) mouse116
Interaction of contractile activity and training history on mRNA abundance in skeletal muscle from trained athletes105
Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies104
Inflammation during obesity is not all bad: evidence from animal and human studies103
Gut bacteria are critical for optimal muscle function: a potential link with glucose homeostasis102
Microbiome potentiates endurance exercise through intestinal acetate production102
Somatostatin restrains the secretion of glucagon-like peptide-1 and -2 from isolated perfused porcine ileum99
Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes91
Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus91
Signaling and biological effects of glucagon-like peptide 1 on the differentiation of mesenchymal stem cells from human bone marrow90
l-Carnitinel-tartrate supplementation favorably affects markers of recovery from exercise stress89
ATP-sensitive K+ channels and disease: from molecule to malady87
Selective activation of PPARγ in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance87
Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression87
Transcriptional regulation of the insulin-responsive glucose transporter GLUT4 gene: from physiology to pathology83
Duodenal-jejunal bypass protects GK rats from β-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-182
PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells82
The gut microbiota is a major regulator of androgen metabolism in intestinal contents81
Quantitative indexes of β-cell function during graded up&down glucose infusion from C-peptide minimal models81
LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training79
Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics76
Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells75
Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans75
Measurement of leucine metabolism in man from a primed, continuous infusion of L-[1-3C]leucine75
Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids75
Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells73
NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions70
Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors70
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart69
Noninvasive measurement of plasma glucose from exhaled breath in healthy and type 1 diabetic subjects69
α-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice68
Impaired PI 3-kinase activation in adipocytes from early growth-restricted male rats67
Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria66
Impaired insulin action in subcutaneous adipocytes from women with visceral obesity66
Measurement of muscle protein fractional synthesis and breakdown rates from a pulse tracer injection65
Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment64
Energy expenditure adjusted for body composition differentiates constitutional thinness from both normal subjects and anorexia nervosa63
Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed rats63
Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats61
Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets60
JNK- and IκB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro58
Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice58
Polyphenolic compounds fromArtemisia dracunculus L.inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line57
Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity57
Cardiovascular benefits associated with higher dietary K+ vs. lower dietary Na+: evidence from population and mechanistic studies56
CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance56
Hypoxia exacerbates nonalcoholic fatty liver disease via the HIF-2α/PPARα pathway54
Akkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement54
Regulation of leptin secretion from white adipocytes by insulin, glycolytic substrates, and amino acids54
Analysis ofN-glycan in serum glycoproteins fromdb/dbmice and humans with type 2 diabetes53
ATP from glycolysis is required for normal sodium homeostasis in resting fast-twitch rodent skeletal muscle51
Lactate release from adipose tissue and skeletal muscle in vivo: defective insulin regulation in insulin-resistant obese women51
Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats50
Lipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes: a comprehensive resource for in vitro studies of hepatic metabolism50
Body mass index, free insulin-like growth factor I, and physical function among older adults: results from the ilSIRENTE study49
Minimal model assessment of hepatic insulin extraction during an oral test from standard insulin kinetic parameters49
Functional characterization of an insulin-responsive glucose transporter (GLUT4) from fish adipose tissue48
Regulation of leptin secretion from white adipocytes by free fatty acids48
Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: evidence for pivotal role of metabolic disturbances48
Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study47
Regulatory roles for small G proteins in the pancreatic β-cell: lessons from models of impaired insulin secretion47
Fecal transplant from resveratrol-fed donors improves glycaemia and cardiovascular features of the metabolic syndrome in mice47
Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle47
COVID-19 endocrinopathy with hindsight from SARS46
Estrogen enhances mechanical stress-induced prostaglandin production by bone cells from elderly women45
Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity45
ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue44
Defective female reproductive function in 1,25(OH)2D-deficient mice results from indirect effect mediated by extracellular calcium and/or phosphorus44
Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle44
Stimulation by iodide of H2O2generation in thyroid slices from several species44
Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant reactive oxygen species production43
Sex-derived attributes contributing to SARS-CoV-2 mortality43
Intact innervation is essential for diet-induced recruitment of brown adipose tissue43
Glycomacropeptide, a low-phenylalanine protein isolated from cheese whey, supports growth and attenuates metabolic stress in the murine model of phenylketonuria43
Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes43
Metabolic control via nutrient-sensing mechanisms: role of taste receptors and the gut-brain neuroendocrine axis43
Correlation between GABA release from rat islet β-cells and their metabolic state42
ELABELA, as a potential diagnostic biomarker of preeclampsia, regulates abnormally shallow placentation via APJ41
Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA41
Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies41
Metabolic effects of insulin on cardiomyocytes from control and diabeticdb/dbmouse hearts41
Colonic fermentation from lactulose inhibits lipolysis in overweight subjects41
Ghrelin and PYY in the regulation of energy balance and metabolism: lessons from mouse mutants41
Measurement of selective effect of insulin on glucose disposal from labeled glucose oral test minimal model40
In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts40
Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis40
Compartmentalization and regulation of iron metabolism proteins protect male germ cells from iron overload40
Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages40
Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells40
Leptin opposes insulin’s effects on fatty acid partitioning in muscles isolated from obese ob/obmice40
Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse40
Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies39
Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion39
Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone38
Reduced activity of mtTFA decreases the transcription in mitochondria isolated from diabetic rat heart38
Interleukin-6 release from human abdominal adipose cells is regulated by thyroid-stimulating hormone: effect of adipocyte differentiation and anatomic depot38
Chylomicron and palmitate metabolism by perfused hearts from diabetic mice38
Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?38
Proton leak and hydrogen peroxide production in liver mitochondria from energy-restricted rats38
Developmental programming of neonatal pancreatic β-cells by a maternal low-protein diet in rats involves a switch from proliferation to differentiation37
miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy37
p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients37
Antipsychotics and glucose metabolism: how brain and body collide37
Extranuclear estrogen receptor's roles in physiology: lessons from mouse models37
The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation36
Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes36
Role of different proteolytic pathways in degradation of muscle protein from streptozotocin-diabetic rats35
Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus35
Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women35
Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage35
IL-6 release from muscles during exercise is stimulated by lactate-dependent protease activity35
Effects of prolonged fasting on AMPK signaling, gene expression, and mitochondrial respiratory chain content in skeletal muscle from lean and obese individuals34
Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids34
PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training34
Evidence of human milk oligosaccharides in maternal circulation already during pregnancy: a pilot study34
Recovery of 13C in breath from NaH13CO3 infused by gut and vein: effect of feeding33
Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes33
Protein kinase C-β mediates lipoprotein-induced generation of PAI-1 from vascular endothelial cells33
Nε-(carboxymethyl) lysine-induced mitochondrial fission and mitophagy cause decreased insulin secretion from β-cells32
Bach1 deficiency protects pancreatic β-cells from oxidative stress injury32
Regulation of CPT I activity in intermyofibrillar and subsarcolemmal mitochondria from human and rat skeletal muscle32
High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment31
Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms31
Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway31
Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit31
The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain31
APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction31
The PERK-EIF2α-ATF4 signaling branch regulates osteoblast differentiation and proliferation by PTH31
In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain31
Long-chain n-3 polyunsaturated fatty acids dissociate phosphorylation of Akt from phosphatidylinositol 3′-kinase activity in rats31
Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice31
Exercise training promotes a GDF15-associated reduction in fat mass in older adults with obesity31
Increased mast cell abundance in adipose tissue of metabolic syndrome: relevance to the proinflammatory state and increased adipose tissue fibrosis31
Pentoxifylline inhibits Ca2+-dependent and ATP proteasome-dependent proteolysis in skeletal muscle from acutely diabetic rats30
Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice30
Sensitivity to metabolic signals in late-gestation growth-restricted fetuses from rapidly growing adolescent sheep30
Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2, leading to cell depolarization and calcium influx30
Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast30
Endothelial dysfunction due to selective insulin resistance in vascular endothelium: insights from mechanistic modeling29
Role of exercise-induced hepatokines in metabolic disorders29
Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy29
Amelioration of metabolic syndrome by metformin associates with reduced indices of low-grade inflammation independently of the gut microbiota29
An update on brown adipose tissue biology: a discussion of recent findings28
From whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitations28
Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice28
Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies28
Adipokines identified as new downstream targets for adiponectin: lessons from adiponectin-overexpressing or -deficient mice28
Sex modulates hepatic mitochondrial adaptations to high-fat diet and physical activity28
Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid.28
Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein28
In vitro lipid synthesis in human adipose tissue from three abdominal sites27
Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP27
Arginine synthesis from enteral glutamine in healthy adults in the fed state27
Comparative expression of hCG β-genes in human trophoblast from early and late first-trimester placentas27
Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss27
Microbial fermentation of flaxseed fibers modulates the transcriptome of GPR41-expressing enteroendocrine cells and protects mice against diet-induced obesity26
Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases26
Quantitative assessment of anaplerosis from propionate in pig heart in vivo26
Chronic fructose renders pancreatic β-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling26
NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism26
A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice26
A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women26
Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice26