American Journal of Physiology-Endocrinology and Metabolism

Article	Citations
Lipoprotein lipase: from gene to obesity	555
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise	380
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans	300
Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice	284
Essential amino acids and muscle protein recovery from resistance exercise	270
IL-6 and TNF-α expression in, and release from, contracting human skeletal muscle	265
Assessment of β-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests	242
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress	184
DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells	176
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity	170
Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis	168
Postexercise net protein synthesis in human muscle from orally administered amino acids	158
Effect of high-intensity intermittent training on lactate and H+ release from human skeletal muscle	155
Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT	147
Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo	140
Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training	133
Minimal model estimation of glucose absorption and insulin sensitivity from oral test: validation with a tracer method	133
Dietary iron restriction or iron chelation protects from diabetes and loss of β-cell function in the obese (ob/ob lep−/−) mouse	116
Interaction of contractile activity and training history on mRNA abundance in skeletal muscle from trained athletes	105
Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies	104
Inflammation during obesity is not all bad: evidence from animal and human studies	103
Gut bacteria are critical for optimal muscle function: a potential link with glucose homeostasis	102
Microbiome potentiates endurance exercise through intestinal acetate production	102
Somatostatin restrains the secretion of glucagon-like peptide-1 and -2 from isolated perfused porcine ileum	99
Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes	91

Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus	91
Signaling and biological effects of glucagon-like peptide 1 on the differentiation of mesenchymal stem cells from human bone marrow	90
l-Carnitinel-tartrate supplementation favorably affects markers of recovery from exercise stress	89
ATP-sensitive K+ channels and disease: from molecule to malady	87
Selective activation of PPARγ in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance	87
Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression	87
Transcriptional regulation of the insulin-responsive glucose transporter GLUT4 gene: from physiology to pathology	83
Duodenal-jejunal bypass protects GK rats from β-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1	82
PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells	82
The gut microbiota is a major regulator of androgen metabolism in intestinal contents	81
Quantitative indexes of β-cell function during graded up&down glucose infusion from C-peptide minimal models	81
LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training	79
Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics	76
Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells	75
Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans	75
Measurement of leucine metabolism in man from a primed, continuous infusion of L-[1-3C]leucine	75
Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids	75
Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells	73
NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions	70
Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors	70
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart	69
Noninvasive measurement of plasma glucose from exhaled breath in healthy and type 1 diabetic subjects	69
α-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice	68
Impaired PI 3-kinase activation in adipocytes from early growth-restricted male rats	67
Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria	66
Impaired insulin action in subcutaneous adipocytes from women with visceral obesity	66
Measurement of muscle protein fractional synthesis and breakdown rates from a pulse tracer injection	65
Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment	64
Energy expenditure adjusted for body composition differentiates constitutional thinness from both normal subjects and anorexia nervosa	63
Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed rats	63
Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats	61
Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets	60
JNK- and IκB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro	58
Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice	58
Polyphenolic compounds fromArtemisia dracunculus L.inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line	57
Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity	57
Cardiovascular benefits associated with higher dietary K+ vs. lower dietary Na+: evidence from population and mechanistic studies	56
CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance	56
Hypoxia exacerbates nonalcoholic fatty liver disease via the HIF-2α/PPARα pathway	54
Akkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement	54
Regulation of leptin secretion from white adipocytes by insulin, glycolytic substrates, and amino acids	54
Analysis ofN-glycan in serum glycoproteins fromdb/dbmice and humans with type 2 diabetes	53
ATP from glycolysis is required for normal sodium homeostasis in resting fast-twitch rodent skeletal muscle	51
Lactate release from adipose tissue and skeletal muscle in vivo: defective insulin regulation in insulin-resistant obese women	51
Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats	50
Lipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes: a comprehensive resource for in vitro studies of hepatic metabolism	50
Body mass index, free insulin-like growth factor I, and physical function among older adults: results from the ilSIRENTE study	49
Minimal model assessment of hepatic insulin extraction during an oral test from standard insulin kinetic parameters	49
Functional characterization of an insulin-responsive glucose transporter (GLUT4) from fish adipose tissue	48
Regulation of leptin secretion from white adipocytes by free fatty acids	48

Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: evidence for pivotal role of metabolic disturbances	48
Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study	47
Regulatory roles for small G proteins in the pancreatic β-cell: lessons from models of impaired insulin secretion	47
Fecal transplant from resveratrol-fed donors improves glycaemia and cardiovascular features of the metabolic syndrome in mice	47
Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle	47
COVID-19 endocrinopathy with hindsight from SARS	46
Estrogen enhances mechanical stress-induced prostaglandin production by bone cells from elderly women	45
Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity	45
ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue	44
Defective female reproductive function in 1,25(OH)2D-deficient mice results from indirect effect mediated by extracellular calcium and/or phosphorus	44
Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle	44
Stimulation by iodide of H2O2generation in thyroid slices from several species	44
Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant reactive oxygen species production	43
Sex-derived attributes contributing to SARS-CoV-2 mortality	43
Intact innervation is essential for diet-induced recruitment of brown adipose tissue	43
Glycomacropeptide, a low-phenylalanine protein isolated from cheese whey, supports growth and attenuates metabolic stress in the murine model of phenylketonuria	43
Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes	43
Metabolic control via nutrient-sensing mechanisms: role of taste receptors and the gut-brain neuroendocrine axis	43
Correlation between GABA release from rat islet β-cells and their metabolic state	42
ELABELA, as a potential diagnostic biomarker of preeclampsia, regulates abnormally shallow placentation via APJ	41
Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA	41
Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies	41
Metabolic effects of insulin on cardiomyocytes from control and diabeticdb/dbmouse hearts	41
Colonic fermentation from lactulose inhibits lipolysis in overweight subjects	41
Ghrelin and PYY in the regulation of energy balance and metabolism: lessons from mouse mutants	41
Measurement of selective effect of insulin on glucose disposal from labeled glucose oral test minimal model	40
In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts	40
Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis	40
Compartmentalization and regulation of iron metabolism proteins protect male germ cells from iron overload	40
Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages	40
Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells	40
Leptin opposes insulin’s effects on fatty acid partitioning in muscles isolated from obese ob/obmice	40
Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse	40
Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies	39
Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion	39
Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone	38
Reduced activity of mtTFA decreases the transcription in mitochondria isolated from diabetic rat heart	38
Interleukin-6 release from human abdominal adipose cells is regulated by thyroid-stimulating hormone: effect of adipocyte differentiation and anatomic depot	38
Chylomicron and palmitate metabolism by perfused hearts from diabetic mice	38
Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?	38
Proton leak and hydrogen peroxide production in liver mitochondria from energy-restricted rats	38
Developmental programming of neonatal pancreatic β-cells by a maternal low-protein diet in rats involves a switch from proliferation to differentiation	37
miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy	37
p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients	37
Antipsychotics and glucose metabolism: how brain and body collide	37
Extranuclear estrogen receptor's roles in physiology: lessons from mouse models	37
The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation	36
Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes	36
Role of different proteolytic pathways in degradation of muscle protein from streptozotocin-diabetic rats	35
Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus	35
Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women	35
Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage	35
IL-6 release from muscles during exercise is stimulated by lactate-dependent protease activity	35
Effects of prolonged fasting on AMPK signaling, gene expression, and mitochondrial respiratory chain content in skeletal muscle from lean and obese individuals	34
Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids	34
PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training	34
Evidence of human milk oligosaccharides in maternal circulation already during pregnancy: a pilot study	34
Recovery of 13C in breath from NaH13CO3 infused by gut and vein: effect of feeding	33
Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes	33
Protein kinase C-β mediates lipoprotein-induced generation of PAI-1 from vascular endothelial cells	33
Nε-(carboxymethyl) lysine-induced mitochondrial fission and mitophagy cause decreased insulin secretion from β-cells	32
Bach1 deficiency protects pancreatic β-cells from oxidative stress injury	32
Regulation of CPT I activity in intermyofibrillar and subsarcolemmal mitochondria from human and rat skeletal muscle	32
High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment	31
Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms	31
Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway	31
Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit	31
The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain	31
APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction	31
The PERK-EIF2α-ATF4 signaling branch regulates osteoblast differentiation and proliferation by PTH	31
In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain	31
Long-chain n-3 polyunsaturated fatty acids dissociate phosphorylation of Akt from phosphatidylinositol 3′-kinase activity in rats	31
Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice	31
Exercise training promotes a GDF15-associated reduction in fat mass in older adults with obesity	31
Increased mast cell abundance in adipose tissue of metabolic syndrome: relevance to the proinflammatory state and increased adipose tissue fibrosis	31
Pentoxifylline inhibits Ca2+-dependent and ATP proteasome-dependent proteolysis in skeletal muscle from acutely diabetic rats	30
Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice	30
Sensitivity to metabolic signals in late-gestation growth-restricted fetuses from rapidly growing adolescent sheep	30
Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2, leading to cell depolarization and calcium influx	30
Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast	30

Endothelial dysfunction due to selective insulin resistance in vascular endothelium: insights from mechanistic modeling	29
Role of exercise-induced hepatokines in metabolic disorders	29
Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy	29
Amelioration of metabolic syndrome by metformin associates with reduced indices of low-grade inflammation independently of the gut microbiota	29
An update on brown adipose tissue biology: a discussion of recent findings	28
From whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitations	28
Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice	28
Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies	28
Adipokines identified as new downstream targets for adiponectin: lessons from adiponectin-overexpressing or -deficient mice	28
Sex modulates hepatic mitochondrial adaptations to high-fat diet and physical activity	28
Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid.	28
Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein	28
In vitro lipid synthesis in human adipose tissue from three abdominal sites	27
Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP	27
Arginine synthesis from enteral glutamine in healthy adults in the fed state	27
Comparative expression of hCG β-genes in human trophoblast from early and late first-trimester placentas	27
Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss	27
Microbial fermentation of flaxseed fibers modulates the transcriptome of GPR41-expressing enteroendocrine cells and protects mice against diet-induced obesity	26
Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases	26
Quantitative assessment of anaplerosis from propionate in pig heart in vivo	26
Chronic fructose renders pancreatic β-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling	26
NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism	26
A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice	26
A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women	26
Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice	26