OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Endocrinology and Metabolism is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
The impact of glucagon to support postabsorptive glucose flux and glycemia in healthy rats and its attenuation in male Zucker diabetic fatty rats	108
Comparison of an oral mixed meal plus arginine and intravenous glucose, GLP-1 plus arginine to unmask residual islet function in longstanding type 1 diabetes	95
Quantitative estimation of disposition index from postprandial glucose data across the spectrum of glucose tolerance	75
Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise	74
Mito-Mendelian interactions alter in vivo glucose metabolism and insulin sensitivity in healthy mice	47
Mammary tumor development induces perturbation of liver glucose metabolism with inflammation and fibrosis	42
Corrigendum for Zhang et al., volume 325, 2023, p. E363–E375	42
Human liver afferent and efferent nerves revealed by 3-D/Airyscan super-resolution imaging	35
Identification of newly synthetized proteins by mass spectrometry to understand palmitate-induced early cellular changes in pancreatic islets	34
A reduction of skeletal muscle DHA content does not result in impaired whole body glucose tolerance or skeletal muscle basal insulin signaling in otherwise healthy mice	33
O-linked N-acetylglucosamine modification is essential for physiological adipose expansion induced by high-fat feeding	32
Duodenal mucosal resurfacing with a GLP-1 receptor agonist increases postprandial unconjugated bile acids in patients with insulin-dependent type 2 diabetes	32
Transorgan short-chain fatty acid fluxes in the fasted and postprandial state in the pig	31
Muscle damaging eccentric exercise attenuates disuse-induced declines in daily myofibrillar protein synthesis and transiently prevents muscle atrophy in healthy men	30
Persistent organic pollutants and β-cell toxicity: a comprehensive review	28
Phosphorylation of AS160-serine 704 is not essential for exercise-increase in insulin-stimulated glucose uptake by skeletal muscles from female or male rats	27
More than meets the islet: aligning nutrient and paracrine inputs with hormone secretion in health and disease	25
Inhibition of protein kinase C-α and activation of ezrin by Lactobacillus acidophilus restore Na⁺/H⁺ exchange activity and fluid absorption in db/db mice	24
α- or β-Adrenergic blockade does not affect transplanted islet cell responses to hypoglycemia in type 1 diabetes	22
Editorial Board	22
Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency	21
A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice	21
Early complete weaning in mice induces hepatic steatosis, which is associated with changes in phospholipids, metabolites, gene expression, and epigenome	20
BRCA1 influences whole body metabolism in humanized mice	20
Metabolic labeling unveils alterations in the turnover of HDL-associated proteins during diabetes progression in mice	20

Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review	19
Epigenetic reprogramming of H3K4me3 in adipose-derived stem cells by HFS diet consumption leads to a disturbed transcriptomic profile in adipocytes	19
NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration	19
Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan	19
Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata	18
Muscle fiber type-specific autophagy responses following an overnight fast and mixed meal ingestion in human skeletal muscle	18
In utero exposure to maternal diabetes exacerbates dietary sodium intake-induced endothelial dysfunction by activating cyclooxygenase 2-derived prostanoids	18
Saturated fat ingestion stimulates proatherogenic inflammation in polycystic ovary syndrome	18
Genetic ablation of the preptin-coding portion of Igf2 impairs pancreatic function in female mice	18
Breaking the vicious cycle: bitter compounds targeting metabolic defects and inflammation in Alzheimer’s disease	18
Mechanisms of spinophilin-dependent pancreas dysregulation in obesity	17
Metabolic shifts in ratio of ucOcn to cOcn toward bone resorption contribute to age-dependent bone loss in male mice	17
Intestinal FFA3 mediates obesogenic effects in mice on a Western diet	17
Metabolic pathways and male fertility: exploring the role of Sertoli cells in energy homeostasis and spermatogenesis	17
Hypothalamus and brainstem circuits in the regulation of glucose homeostasis	16
Adipocyte traits limiting cellular insulin responsiveness and glucose transport	16
Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes	16
Retraction for Jiang et al., volume 304, 2012, p. E74–E86	16
Heme-based oxygen gasoreceptors	16
Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers	15
Synergistic effects of glucose tolerance and BMI on cardiovascular events and all-cause mortality in a healthy population: CA.ME.LI.A study 7 years follow-up	15
Defective muscle ketone body oxidation disrupts BCAA catabolism by altering mitochondrial branched-chain aminotransferase	15
Genealogical Rabson–Mendenhall syndrome caused by INSR gene mutation	15
Increased gut serotonin production in response to bisphenol A structural analogs may contribute to their obesogenic effects	14
Spatiotemporally quantitative in vivo imaging of mitochondrial fatty acid β-oxidation at cellular-level resolution in mice	14
Chronic succinate exposure does not cause liver injury	14
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction	14
A new C-peptide minimal model to assess β-cell responsiveness to glucagon in individuals with and without type 2 diabetes	13
Roux-en-Y gastric bypass alleviates kidney inflammation and improves kidney function in db/db mice by activating TLCA/TGR5 pathway	13
Deconstructing interindividual variability in energy metabolism: implications for metabolic health	13
Brown adipose tissue metabolism in women is dependent on ovarian status	13
T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling	13
Sex-specific difference in intestinal glucose metabolism is associated with sexually dimorphic postprandial lactate shuttle and glucose homeostasis in mice	13
Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood	13
Muscle wasting and the response to exercise in lung-injured mice is not primarily driven through the glucocorticoid axis	13
Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury	13
A physiologic increase in brain glucagon action alters the hepatic gluconeogenic/glycogenolytic ratio but not glucagon’s overall effect on glucose production	13
Paternal obesity decreases infant MSC mitochondrial functional capacity	13
Disruption of hepatic mitochondrial pyruvate and amino acid metabolism impairs gluconeogenesis and endurance exercise capacity in mice	12
Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes	12
Reply to Lund et al.	12
Effects of follicle-stimulating hormone on energy balance and tissue metabolic health after loss of ovarian function	12
Endothelial β1-integrins are necessary for microvascular function and glucose uptake	12
Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability	12
Effect of ghrelin on glucose tolerance, gut hormones, appetite, and food intake after sleeve gastrectomy	12
Roles of circadian clocks in macrophage metabolism: implications in inflammation and metabolism of lipids, glucose, and amino acids	12
Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function	12
Greater reliance on glycolysis is associated with lower mitochondrial substrate oxidation and insulin sensitivity in infant myogenic MSCs	12
Sugar type and route of delivery influence insulin and glucose-dependent insulinotropic polypeptide responses in rats	12
Generation and characterization of a mouse model for one anastomosis gastric bypass surgery	12

Central lipid sensing pathways contribute to the control of puberty and its alterations in conditions of obesity	12
Absence of Slc39a14/Zip14 in mouse pancreatic beta cells results in hyperinsulinemia	11
Activation of β-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice	11
Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression	11
Potential role of skeletal muscle glycerophosphocholine in response to altered fluid balance in humans: an in vivo nuclear magnetic resonance study	11
Ethnic differences in postprandial fatty acid trafficking and utilization between overweight and obese White European and Black African-Caribbean men	11
Assessment of the incretin effect in healthy subjects: concordance between clamp and OGTT methods	11
Constitutive loss of kynurenine-3-monooxygenase changes circulating kynurenine metabolites without affecting systemic energy metabolism	11
Increasing maternal glucose concentrations is insufficient to restore placental glucose transfer in chorionic somatomammotropin RNA interference pregnancies	11
Key questions and gaps in understanding adipose tissue macrophages and early-life metabolic programming	11
L-type Calcium Channel Blockade Worsens Glucose Tolerance and β-Cell Function in C57BL6/J Mice Exposed to Intermittent Hypoxia	11
Effect of in utero metformin exposure in gestational diabetes mellitus on infant mesenchymal stem cell metabolism	10
The influence of interleukin-27 on metabolic fitness in a murine neonatal model of bacterial sepsis	10
Fasting potentiates insulin-mediated glucose uptake in rested and prior-contracted rat skeletal muscle	10
Sedentary time associates detrimentally and physical activity beneficially with metabolic flexibility in adults with metabolic syndrome	10
Thermoneutral housing does not accelerate metabolic dysfunction-associated fatty liver disease in male or female C57Bl/6J mice fed a Western diet	10
Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer	10
Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice	10
Obesity wars: may the smell be with you	10
Pantothenate protects against obesity via brown adipose tissue activation	10
Vitamin E treatment in insulin-deficient diabetic rats reduces cardiac arrhythmias and mortality during severe hypoglycemia	9
Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids	9
Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models	9
Distinct endothelial gene responses to acute exercise in skeletal muscle	9
Fat and not sugar as the determining factor for gut microbiota changes, obesity, and related metabolic disorders in mice	9
Hepatic mTORC2 compensates for loss of adipose mTORC2 in mediating energy storage and glucose homeostasis	9
Hepatocyte HIF-2α aggravates NAFLD by inducing ferroptosis through increasing extracellular iron	9
17α-Estradiol alleviates high-fat diet-induced inflammatory and metabolic dysfunction in skeletal muscle of male and female mice	9
The enduring metabolic improvement of combining dual amylin and calcitonin receptor agonist and semaglutide treatments in a rat model of obesity and diabetes	9
An isoproteic cocoa butter-based ketogenic diet fails to improve glucose homeostasis and promote weight loss in obese mice	9
Higher AMPK activation in mouse oxidative compared with glycolytic muscle does not correlate with LKB1 or CaMKKβ expression	9
The role of postprandial thermogenesis in the development of impaired glucose tolerance and type II diabetes	9
Deletion of complement factor 5 amplifies glucose intolerance in obese male but not female mice	9
Extracellular flux analyses reveal differences in mitochondrial PBMC metabolism between high-fit and low-fit females	9
Downregulation of the mitochondrial tRNA-derived fragment mt-tRF-Leu^TAA enhances skeletal muscle insulin sensitivity	9
Duration of morning hyperinsulinemia determines hepatic glucose uptake and glycogen storage later in the day	9
PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice	9
The nervous system and adipose tissues: a tale of dialogues	9
Maintenance of thermogenic adipose tissues despite loss of the H3K27 acetyltransferases p300 or CBP	9
Maternal genetics and diet modulate vitamin A homeostasis of the offspring and affect the susceptibility to obesity in adulthood in mice	8
Effects of 1,144 km of road cycling performed in 7 days: a cardiometabolic imaging study	8
Protein intake counteracts alcohol intake in the regulation of postprandial FGF21 secretion in humans	8
Enhanced quantification of α-cell suppression by hyperglycemia using a high-sensitivity glucagon assay	8
Corrigendum for Waterman et al., volume 327, 2024, p. E655–E667	8
Understanding how pre- and probiotics affect the gut microbiome and metabolic health	8
CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner	8
Discovery of a novel regulator, 3β-sulfate-5-cholestenoic acid, of lipid metabolism and inflammation	8
Energy expenditure due to gluconeogenesis in pathological conditions of insulin resistance	8
The effect of repeated hot water immersion on insulin sensitivity, heat shock protein 70, and inflammation in individuals with type 2 diabetes mellitus	8
Corrigendum for Subramanian et al., volume 326, 2024, p. E182–E205	8
The antiemetic actions of GIP receptor agonism	8
Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease	8
Hydrolyzed collagen supplementation prior to resistance exercise augments collagen synthesis in a dose-response manner in resistance-trained, middle-aged men	8
Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats	8
17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice	8
The evolution of steatosis and fibrosis in mice on a MASH-inducing diet and the effects of housing temperature	7
Glucagon increases plasma levels of Cyclic AMP responses in mice and humans, and this may be independent of MASLD	7
Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function	7
The timing of intermittent hypoxia differentially affects macronutrient intake and energy substrate utilization in mice	7
Association of aerobic fitness and body composition with protein and major lipid class composition of high-density lipoprotein	7
AQP1- A regulatory factor associated with brown adipose tissue-silencing to combat obesity and metabolic disease	7
Cold acclimation and pioglitazone combined increase thermogenic capacity of brown and white adipose tissues but this does not translate into higher energy expenditure in mice	7
Perineuronal nets’ role in metabolism	7
Low-frequency ultrasound reverses insulin resistance and diabetes-induced changes in the muscle transcriptome in aged mice	7
Menstrual cycle phase differences in myofiber damage and macrophage infiltration following electrical stimulation-induced muscle injury	7
Plasma complement system markers and their association with cardiometabolic risk factors: an ethnic comparison of White European and Black African men	7
Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner	7
Insulin secretion and action and the response of endogenous glucose production to a lack of glucagon suppression in nondiabetic subjects	7
Development of a synbiotic that protects against ovariectomy-induced trabecular bone loss	7
c-Myc overexpression increases ribosome biogenesis and protein synthesis independent of mTORC1 activation in mouse skeletal muscle	7
Corrigendum for Li et al., volume 308, 2014, p. E257–E269	7
Gut lactate increases circulating l-Lac-Phe and key metabolites linked to GLP-1 and human health	7
Intramuscular diacylglycerol accumulates with acute hyperinsulinemia in insulin-resistant phenotypes	7
Prostaglandin EP3 receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance	7
Untargeted metabolomic profiling identifies serum metabolites associated with type 2 diabetes in a cross-sectional study of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study	7
Chronic AT₁ blockade improves hyperglycemia by decreasing adipocyte inflammation and decreasing hepatic PCK1 and G6PC1 expression in obese rats	7
Disruption of neuromedin B receptor improves mitochondrial oxidative phosphorylation capacity in gastrocnemius muscle of female mice	7