OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Endocrinology and Metabolism is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity	158
Bilirubin as a metabolic hormone: the physiological relevance of low levels	106
DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway	92
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity	72
An update on brown adipose tissue biology: a discussion of recent findings	60
Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8	58
COVID-19 endocrinopathy with hindsight from SARS	55
Insulin Action in the Brain regulates both Central and Peripheral Functions	52
High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling	48
Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound	46
Obesity and chronic kidney disease	45
A ketogenic diet combined with exercise alters mitochondrial function in human skeletal muscle while improving metabolic health	44
Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases	41
Vitamin D and lumisterol novel metabolites can inhibit SARS-CoV-2 replication machinery enzymes	41
100^th anniversary of the discovery of insulin perspective: insulin and adipose tissue fatty acid metabolism	39
SARS-CoV-2: influence of phosphate and magnesium, moderated by vitamin D, on energy (ATP) metabolism and on severity of COVID-19	38
Insulin Signaling In the Heart	36
Apigenin promotes osteogenic differentiation of mesenchymal stem cells and accelerates bone fracture healing via activating Wnt/β-catenin signaling	36
Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis	34
Glucagon-like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of rapamycin pathway	34
Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices	34
Is GLUT4 translocation the answer to exercise-stimulated muscle glucose uptake?	33
Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes	32
Paracrine and autocrine control of insulin secretion in human islets: evidence and pending questions	31
Luteolin alleviates polycystic ovary syndrome in rats by resolving insulin resistance and oxidative stress	31

Mitochondria-associated ER membranes in glucose homeostasis and insulin resistance	30
Exercise and estrogen: common pathways in Alzheimer's disease pathology	30
Resveratrol mediates the miR-149/HMGB1 axis and regulates the ferroptosis pathway to protect myocardium in endotoxemia mice	30
Diabetic ketoacidosis and COVID-19: what have we learned so far?	29
Persistent organic pollutants and β-cell toxicity: a comprehensive review	29
Diet during early life defines testicular lipid content and sperm quality in adulthood	29
MOTS-c reduces myostatin and muscle atrophy signaling	27
Loss of CTRP4 alters adiposity and food intake behaviors in obese mice	26
Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms	26
Higher protein intake during resistance training does not potentiate strength, but modulates gut microbiota, in middle-aged adults: a randomized control trial	25
Estradiol treatment or modest exercise improves hepatic health and mitochondrial outcomes in female mice following ovariectomy	25
β-Cell autophagy in the pathogenesis of type 1 diabetes	25
Increased vascular permeability and severe renal tubular damage after ischemia-reperfusion injury in mice lacking adiponectin or T-cadherin	24
Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver disease	24
Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women	24
Overexpression of histone deacetylase SIRT1 exerts an antiangiogenic role in diabetic retinopathy via miR-20a elevation and YAP/HIF1α/VEGFA depletion	23
Considerations and challenges of islet transplantation and future therapies on the horizon	23
Human blood contains circulating cell-free mitochondria, but are they really functional?	22
Gut-to-brain signals in feeding control	21
The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism	21
GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism	20
Exploring the link between vitamin D and clinical outcomes in COVID-19	20
High-resolution analysis of the cytosolic Ca²⁺ events in β cell collectives in situ	20
Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways	20
Holistic characterization of single-hepatocyte transcriptome responses to high-fat diet	19
Separating insulin-mediated and non-insulin-mediated glucose uptake during and after aerobic exercise in type 1 diabetes	19
Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1	19
The promising future of insulin therapy in diabetes mellitus	19
c-Myc overexpression increases ribosome biogenesis and protein synthesis independent of mTORC1 activation in mouse skeletal muscle	19
Effects of carbohydrate restriction on postprandial glucose metabolism, β-cell function, gut hormone secretion, and satiety in patients with Type 2 diabetes	19
Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men	19
Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points	18
Deficiency of arcuate nucleus kisspeptin results in postpubertal central hypogonadism	18
Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice	18
Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle	18
Fight against fibrosis in adipose tissue remodeling	18
Peripheral and central regulation of insulin by the intestine and microbiome	17
Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults	17
Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling	17
Mesenchymal stem cells alleviate palmitic acid-induced endothelial-to-mesenchymal transition by suppressing endoplasmic reticulum stress	17
Involvement of sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) in mPRα (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation	17
Inosine, gut microbiota, and cancer immunometabolism	17
Astragaloside IV ameliorates preeclampsia-induced oxidative stress through the Nrf2/HO-1 pathway in a rat model	16
Worsening baroreflex sensitivity on progression to type 2 diabetes: localized vs. systemic inflammation and role of antidiabetic therapy	16
Genetically increasing flux through β-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance	16
Oral and intestinal microbial features in pregnant women with hypothyroidism and their correlations with pregnancy outcomes	16
Sex differences in fat taste responsiveness are modulated by estradiol	16
Reproductive and metabolic adaptation to multistressor training in women	16
Exercise Effect on Insulin-Dependent and Insulin-Independent Glucose Utilization in Healthy and Type 1 Diabetes Individuals. A Modeling Study.	15
Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity	15

Fat and not sugar as the determining factor for gut microbiota changes, obesity, and related metabolic disorders in mice	15
Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice	15
Role of creatine and creatine kinase in UCP1-independent adipocyte thermogenesis	15
Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure	15
Dietary nitrate increases submaximal SERCA activity and ADP transfer to mitochondria in slow-twitch muscle of female mice	15
Impact of prolonged fasting on insulin secretion, insulin action, and hepatic versus whole body insulin secretion disposition indices in healthy young males	15
Lactylation: novel epigenetic regulatory and therapeutic opportunities	15
Metformin prevents endothelial oxidative stress and microvascular insulin resistance during obesity development in male rats	14
Myostatin deficiency not only prevents muscle wasting but also improves survival in septic mice	14
Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide	14
Amelioration of bone fragility by pulsed electromagnetic fields in type 2 diabetic KK-Ay mice involving Wnt/β-catenin signaling	14
Increased postprandial nonesterified fatty acid efflux from adipose tissue in prediabetes is offset by enhanced dietary fatty acid adipose trapping	14
Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs	14
Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice	14
Mitochondrial transformations in the aging human placenta	14
Duodenal mucosal resurfacing with a GLP-1 receptor agonist increases postprandial unconjugated bile acids in patients with insulin-dependent type 2 diabetes	14
Metformin improves skeletal muscle microvascular insulin resistance in metabolic syndrome	14
Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21	13
Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity	13
On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice	13
Long-term light and moderate exercise intervention similarly prevent both hippocampal and glycemic dysfunction in presymptomatic type 2 diabetic rats	13
Uncoupling protein-1 expression does not protect mice from diet-induced obesity	13
GPR40 deficiency is associated with hepatic FAT/CD36 upregulation, steatosis, inflammation, and cell injury in C57BL/6 mice	13
Sex differences in autonomic responses to stress: implications for cardiometabolic physiology	12
CTRP6 rapidly responds to acute nutritional changes, regulating adipose tissue expansion and inflammation in mice	12
Cumulative insulin resistance and hyperglycemia with arterial stiffness and carotid IMT progression in 1,779 adolescents: a 9-yr longitudinal cohort study	12
Importance of the route of insulin delivery to its control of glucose metabolism	12
IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus	12
GLP1 receptor agonism protects against acute olanzapine-induced hyperglycemia	12
The endocrine effects of bitter tastant administration in the gastrointestinal system: intragastric versus intraduodenal administration	12
Visceral adipose tissue mesenchymal stromal cells in the intersection of immunology and metabolism	12
The prorenin receptor and its soluble form contribute to lipid homeostasis	12
β₂-Adrenergic Receptor Agonist Induced Hepatic Steatosis in Mice: Modeling Nonalcoholic Fatty Liver Disease in Hyperadrenergic States	11
Exacerbated obesogenic response in female mice exposed to early life stress is linked to fat depot-specific upregulation of leptin protein expression	11
A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice	11
Adrenal insufficiency in the COVID-19 era	11
Light intensity alters the effects of light-induced circadian disruption on glucose and lipid metabolism in mice	11
Neprilysin inhibition improves intravenous but not oral glucose-mediated insulin secretion via GLP-1R signaling in mice with β-cell dysfunction	11
Effect of hypoxic exercise on glucose tolerance in healthy and prediabetic adults	11
Adipsin deficiency does not impact atherosclerosis development in Ldlr^−/− mice	11
Myeloid-specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice	11
Maternal hypercortisolemia alters placental metabolism: a multiomics view	11
CB1Rs in VMH neurons regulate glucose homeostasis but not body weight	11
Higher glucose availability augments the metabolic responses of the C2C12 myotubes to exercise-like electrical pulse stimulation	10
Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats	10
Estetrol prevents Western diet–induced obesity and atheroma independently of hepatic estrogen receptor α	10
1,25-Dihydroxyvitamin D deficiency accelerates male reproductive senescence in aging mice and 1,25(OH)₂D₃alleviates oxidative stress via NF-κB/SOD	10
Roux-en-Y gastric bypass restores islet function and morphology independent of body weight in ZDF rats	10
CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding	10
Alterations of gut microbiome in patients with type 2 diabetes mellitus who had undergone cholecystectomy	10
Estrogen-Wnt signaling cascade regulates expression of hepatic fibroblast growth factor 21	10
Extracellular flux analyses reveal differences in mitochondrial PBMC metabolism between high-fit and low-fit females	10
Central GLP-1 contributes to improved cognitive function and brain glucose uptake after duodenum-jejunum bypass on obese and diabetic rats	10
Androgen signaling in adipose tissue, but less likely skeletal muscle, mediates development of metabolic traits in a PCOS mouse model	10
Assessment of individual and standardized glucagon kinetics in healthy humans	10
Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study	10
Creatine synthesis in the skeletal muscle: the times they are a-changin’	9
Ingestion of mycoprotein, pea protein, and their blend support comparable postexercise myofibrillar protein synthesis rates in resistance-trained individuals	9
Acute binge alcohol alters whole body metabolism and the time-dependent expression of skeletal muscle-specific metabolic markers for multiple days in mice	9
Ketone monoester ingestion increases postexercise serum erythropoietin concentrations in healthy men	9
Long-chain acyl-CoA synthetase-1 mediates the palmitic acid-induced inflammatory response in human aortic endothelial cells	9
Transcriptomic responses are sex-dependent in the skeletal muscle and liver in offspring of obese mice	9
Acute cardiometabolic effects of brief active breaks in sitting for patients with rheumatoid arthritis	9
The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation	9
Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids	9
Vitamin D supplementation induces CatG-mediated CD4⁺ T cell inactivation and restores pancreatic β-cell function in mice with type 1 diabetes	9
Visualizing and quantifying cutaneous microvascular reactivity in humans by use of optical coherence tomography: impaired dilator function in diabetes	9
Prolonged β₂-adrenergic agonist treatment improves glucose homeostasis in diet-induced obese UCP1^−/− mice	9
PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice	9
Acute carbohydrate overfeeding: a redox model of insulin action and its impact on metabolic dysfunction in humans	9
Muscle damaging eccentric exercise attenuates disuse-induced declines in daily myofibrillar protein synthesis and transiently prevents muscle atrophy in healthy men	9