Toxicologic Pathology

Papers
(The TQCC of Toxicologic Pathology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
A Pathologist’s Guide to Non-clinical Safety Assessment of Adoptive Cell Therapy Products135
Symmetric Dimethylarginine Is a Sensitive Biomarker of Glomerular Injury in Rats84
Early-Onset Asymptomatic Polypoid Cystitis in Two Adolescent Male Beagle Dogs29
Guide for Combining Primary Tumors for Statistical Analysis in Rodent Carcinogenicity Studies27
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies26
Spontaneous Findings in the Reproductive System of Sexually Mature Male Cynomolgus Macaques25
Toxicity and Local Tolerance of COVID- eVax, a Plasmid DNA Vaccine for SARS-CoV-2, Delivered by Electroporation20
Kidney Effects by Alternative Classes of Medicines in Patients and Relationship to Effects in Nonclinical Toxicity Studies19
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman 16
In Utero Exposure to 3,3′,4,4′, 5-Pentachlorobiphenyl Dose-Dependently Induces N-butyl-4-(hydroxybutyl) Nitrosamine in Rats With Urinary Bladder Carcinoma16
Artificial Intelligence in Toxicological Pathology: Quantitative Evaluation of Compound-Induced Follicular Cell Hypertrophy in Rat Thyroid Gland Using Deep Learning Models16
Toxicologic Pathology Forum: mRNA Vaccine Safety–Separating Fact From Fiction13
Toxicologic Pathology Forum*: Opinion on Assessing and Communicating Adversity for Implantable Medical Devices12
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies12
Retraction Notice: “Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats”12
Scientific and Regulatory Policy Committee Points to Consider for Medical Device Implant Site Evaluation in Nonclinical Studies11
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity11
Difference in the Mechanism of Iron Overload–Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats10
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats10
Society of Toxicologic Pathology Nonhuman Primate Special Interest Group: Idiopathic Femoral Head Chondrolysis in Nonclinical Research Macaques10
Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vectors10
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studi9
Opinion on the Optimal Histologic Evaluation of the Bone Marrow in Nonclinical Toxicity Studies9
Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies9
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice9
Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology9
Organ Weights in Relation to Age and Sex in Cynomolgus Monkeys (Macaca fascicularis)8
Virtual Control Groups in Non-clinical Toxicity Studies: Impacts on Toxicologic Clinical Pathology Data Interpretation8
Comparative Impact of Various Fasting Periods on the Welfare of Sprague-Dawley Rats With or Without Supplementation8
Selected Resources for Pathology Evaluation of Nonhuman Primates in Nonclinical Safety Assessment8
Applications of Cell-Based Protein Array Technology to Preclinical Safety Assessment of Biological Products7
Identifying Erythrocyte Injury in Toxicology Studies7
Cardiac Rhabdomyoma in Four Göttingen Minipigs7
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure6
Neurofilament Light Chain: A Translational Safety Biomarker for Drug-Induced Peripheral Neurotoxicity6
Deep Learning Methodology for Quantification of Normal Pancreas Structures6
Safety and Performance Evaluation of Su2ura Approximation, a New Suturing Device, in Pigs6
Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry6
Proceedings of the 2022 National Toxicology Program Satellite Symposium6
Thank You to Reviewers6
Possible Cytoprotection of Low Dose Lipopolysaccharide in Rat Thioacetamide-Induced Liver Lesions, Focusing on the Analyses of Hepatic Macrophages and Autophagy5
Morphologic Features and Deep Learning–Based Analysis of Canine Spermatogenic Stages5
Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution5
Toxicologic Pathology Forum: Tissue Evaluation in Nonclinical Toxicity Studies for Prophylactic Vaccines5
Immunotoxicology From a Pathology Perspective: A Continuing Education Course Presented at the Annual STP Meeting in Baltimore, MD, Held June 16-19, 20245
Scientific and Regulatory Policy Committee Points to Consider: Biological Sample Retention From Nonclinical Toxicity Studies5
Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat5
Assessing the Carcinogenicity of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, in Rodents5
Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays4
Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies4
Effects of LRRK2 Inhibitors in Nonhuman Primates4
Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies4
An Overview of Nonclinical and Clinical Liver Toxicity Associated With AAV Gene Therapy4
Bortezomib-Induced Ovarian Toxicity in Mice4
Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey ( Macaca fascicularis )4
Phthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans4
Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies4
Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling4
IT/QA and Regulatory Aspects of Digital Pathology: Results of the 8th ESTP International Workshop4
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