OOIR: Observatory of International Research

Papers

(The median citation count of Toxicologic Pathology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Kidney Effects by Alternative Classes of Medicines in Patients and Relationship to Effects in Nonclinical Toxicity Studies	124
A Pathologist’s Guide to Non-clinical Safety Assessment of Adoptive Cell Therapy Products	81
Symmetric Dimethylarginine Is a Sensitive Biomarker of Glomerular Injury in Rats	29
Early-Onset Asymptomatic Polypoid Cystitis in Two Adolescent Male Beagle Dogs	26
Guide for Combining Primary Tumors for Statistical Analysis in Rodent Carcinogenicity Studies	25
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies	24
Spontaneous Findings in the Reproductive System of Sexually Mature Male Cynomolgus Macaques	20
Toxicity and Local Tolerance of COVID- eVax, a Plasmid DNA Vaccine for SARS-CoV-2, Delivered by Electroporation	19
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman	16
In Utero Exposure to 3,3′,4,4′, 5-Pentachlorobiphenyl Dose-Dependently Induces N-butyl-4-(hydroxybutyl) Nitrosamine in Rats With Urinary Bladder Carcinoma	16
Artificial Intelligence in Toxicological Pathology: Quantitative Evaluation of Compound-Induced Follicular Cell Hypertrophy in Rat Thyroid Gland Using Deep Learning Models	16
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies	13
Toxicologic Pathology Forum: mRNA Vaccine Safety–Separating Fact From Fiction	12
Toxicologic Pathology Forum*: Opinion on Assessing and Communicating Adversity for Implantable Medical Devices	12
Retraction Notice: “Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats”	11
Scientific and Regulatory Policy Committee Points to Consider for Medical Device Implant Site Evaluation in Nonclinical Studies	11
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity	11
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats	11
Difference in the Mechanism of Iron Overload–Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats	10
Society of Toxicologic Pathology Nonhuman Primate Special Interest Group: Idiopathic Femoral Head Chondrolysis in Nonclinical Research Macaques	10
Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vectors	10
Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies	9
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studi	9
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice	9
Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology	9

Organ Weights in Relation to Age and Sex in Cynomolgus Monkeys (Macaca fascicularis)	9
Opinion on the Optimal Histologic Evaluation of the Bone Marrow in Nonclinical Toxicity Studies	8
Virtual Control Groups in Non-clinical Toxicity Studies: Impacts on Toxicologic Clinical Pathology Data Interpretation	8
Selected Resources for Pathology Evaluation of Nonhuman Primates in Nonclinical Safety Assessment	8
Applications of Cell-Based Protein Array Technology to Preclinical Safety Assessment of Biological Products	7
Comparative Impact of Various Fasting Periods on the Welfare of Sprague-Dawley Rats With or Without Supplementation	7
Identifying Erythrocyte Injury in Toxicology Studies	7
Cardiac Rhabdomyoma in Four Göttingen Minipigs	7
Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry	6
Morphologic Features and Deep Learning–Based Analysis of Canine Spermatogenic Stages	6
Safety and Performance Evaluation of Su2ura Approximation, a New Suturing Device, in Pigs	6
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure	6
Thank You to Reviewers	6
Neurofilament Light Chain: A Translational Safety Biomarker for Drug-Induced Peripheral Neurotoxicity	6
Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution	5
Toxicologic Pathology Forum: Tissue Evaluation in Nonclinical Toxicity Studies for Prophylactic Vaccines	5
Deep Learning Methodology for Quantification of Normal Pancreas Structures	5
Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies	5
Brief Synopsis: “Instruction Manual for Juvenile Clinical Pathology”	5
Possible Cytoprotection of Low Dose Lipopolysaccharide in Rat Thioacetamide-Induced Liver Lesions, Focusing on the Analyses of Hepatic Macrophages and Autophagy	5
Proceedings of the 2022 National Toxicology Program Satellite Symposium	5
Bortezomib-Induced Ovarian Toxicity in Mice	5
Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat	5
Scientific and Regulatory Policy Committee Points to Consider: Biological Sample Retention From Nonclinical Toxicity Studies	5
Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies	4
An Overview of Nonclinical and Clinical Liver Toxicity Associated With AAV Gene Therapy	4
Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling	4
Immunotoxicology From a Pathology Perspective: A Continuing Education Course Presented at the Annual STP Meeting in Baltimore, MD, Held June 16-19, 2024	4
Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies	4
Assessing the Carcinogenicity of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, in Rodents	4
Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays	4
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Diving Head-First Into the Deep Digital Pool!	4
Histology Atlas of the Developing Mouse Respiratory System From Prenatal Day 9.0 Through Postnatal Day 30	3
Immune-Mediated Liver Effects Associated With Administration of a Human Anti-IL-21 Receptor Antibody (ATR-107) in Rats	3
Regulatory Perspectives on Juvenile Animal Toxicologic Pathology	3
Toxicologic Pathology Forum: Opinion on Approaches for Reporting Toxic and Adverse Dose Levels in Nonclinical Toxicology Studies Supporting the Development of Anticancer Pharmaceuticals	3
Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey ( Macaca fascicularis )	3
The Impact of Functional and Structural Maturation of the Kidney on Susceptibility to Drug and Chemical Toxicity in Neonatal Rodents	3
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Are We There Yet?	3
To Clot or Not to Clot: Deepening Our Understanding of Alterations in the Hemostatic System	3
Session 4: mRNA and Self-Amplifying RNA (saRNA): Opportunities for Disease Prevention and Therapy	3
Proceedings of the 2021 National Toxicology Program Satellite Symposium	3
Scientific and Regulatory Policy Committee Points to Consider: Fixation, Trimming, and Sectioning of Nonrodent Eyes and Ocular Tissues for Examination in Ocular and General Toxicity Studies	3
Corrigendum to Histology Atlas of the Developing Mouse Placenta	3
Phthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans	3
Toxicologic Pathology Forum*: Opinion on New Technologies and Trends Disrupting Drug Discovery and Development: How Can the Next Generation of Toxicologic Pathologists Be Prepared for Evolving Roles?	3
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing	3
Post-Pandemic Pathology Practice	3
Special Issue on the Pathobiology of Laboratory Nonhuman Primates: A Review of Species, Substrain, Geographical Origin, Age, and Modality-Related Factors	3
Pathological Characterization of Spontaneous AA Amyloidosis in Microminipigs	3

Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies	3
Effects of LRRK2 Inhibitors in Nonhuman Primates	3
IT/QA and Regulatory Aspects of Digital Pathology: Results of the 8th ESTP International Workshop	3
Immunohistochemical Characterization of Proliferative Lesions in the Thymus of Aging CD-1 Mice From Two Studies on the RITA Database, With Special Reference to the Perivascular Space	2
Extraintestinal Pathogenic Escherichia Coli Causes Necrohemorrhagic Pneumonia in Multiple Research Dogs	2
Society of Toxicologic Pathology Neuropathology Interest Group Article: Neuropathologic Findings in Nonhuman Primates Associated With Administration of Biomolecule-Based Test Articles	2
Proceedings of the 2023 Annual Scientific Meeting of the French Society of Toxicologic Pathology (SFPT) on Preclinical Development and Therapeutic Applications of mRNA-Based Technologies	2
Results of the European Society of Toxicologic Pathology Survey on the Use of Artificial Intelligence in Toxicologic Pathology	2
Historical Control Data of Spontaneous Lesions of Laboratory New Zealand White and Dutch Belted Rabbits ( Oryctolagus Cuniculus ) Used in Toxicity Studies	2
Prenatal Evaluations: A Prologue to Postnatal Pathology Interpretations	2
Toxicologic Pathology Forum*: Opinion on Qualitative Severity Descriptors to Express Magnitude of Changes in Clinical Pathology Endpoints in Nonclinical Toxicity Studies	2
Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development	2
Neuropathology Evaluation in Juvenile Toxicity Studies in Rodents: Comparison of Developmental Neurotoxicity Studies for Chemicals With Juvenile Animal Studies for Pediatric Pharmaceuticals	2
Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig	2
Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice	2
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop	2
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats	2
Proceedings of the 2024 Division of Translational Toxicology Satellite Symposium	2
Does Geographical Origin of Long-Tailed Macaques (Macaca fascicularis) Matter in Drug Safety Assessment?: A Literature Review and Proposed Conclusion	2
How Does Lifestyle Affect Hematopoiesis and the Bone Marrow Microenvironment?	2
Complex In Vitro Model Characterization for Context of Use in Toxicologic Pathology: Use Cases by Collaborative Teams of Biologists, Bioengineers, and Pathologists	2
A Fandango of Form and Function: The Interplay Between Clinical Neurology and Neuropathology Evaluation	2
Digital Pathology and Artificial Intelligence Applied to Nonclinical Toxicology Pathology—The Current State, Challenges, and Future Directions	2
Spontaneous Primary Pleural Mesothelioma in Fischer 344 (F344) and Other Rat Strains: A Retrospective Review	2
2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives	2
Granulocytosis, a Paraneoplastic Syndrome Associated With Non-Glandular Squamous Cell Carcinomas (NGSCC) in the Tg.rasH2 Studies	2
Pathology of Bone: Changes Associated With Different Classes of Compounds	1
A Developmental Atlas as a Reflection of Our Professional Lifecycle	1
Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery	1
Myelin Methods: A Mini-Review	1
Pseudoreticulocytosis by the ADVIA 2120 Hematology Analyzer and Other Hematologic Changes in a Cynomolgus Macaque (Macaca fascicularis) With Malaria	1
Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver	1
Molecular Pathology Methods to Characterize Biodistribution and Pharmacodynamics of the Oncolytic Virus VSV-GP in a Nonclinical Tumor Model	1
Toxicologic Pathology Forum Opinion Piece: Use of Virtual Control Groups in Nonclinical Toxicity Studies: The Anatomic Pathology Perspective	1
Risk Assessment for Hepatobiliary Toxicity Liabilities in Drug Development	1
IHI VICT3R: Developing and Implementing Virtual Control Groups to Reduce Animal Use in Toxicology Research	1
Comparison of ANP and BNP Granular Density in Atria of Rats After Physiological and Pathological Hypertrophy	1
Exogenous Growth Hormone Exacerbates Post-Irradiation Atherosclerosis in Susceptible Epicardial Coronary Arteries	1
Poster Abstracts of the 20^th Congress of the European Society of Toxicologic Pathology (Basel, Switzerland, 26th - 29th of September 2023, Emerging Therapeutic Modalities)	1
Book Review: Toxicologic Pathology for Non-Pathologists	1
Gastric Neuroendocrine Tumors With Parietal Cell Atrophy in a Long-term Carcinogenicity Study in Rats	1
Applications of Molecular Pathology: An Evolving Approach to Toxicologic Pathology	1
Thyroid Hormone Imbalance in Pregnant Rats and its Impact on Neurodevelopment in Pups: A Minireview on Histopathological Endpoints	1
Assessment of Color Reproducibility and Mitigation of Color Variation in Whole Slide Image Scanners for Toxicologic Pathology	1
Obituary: Dr Gordon Charles Hard (1931-2021)	1
Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques	1
Carcinogenicity Evaluation of Baclofen in TgrasH2 Mice	1
Pathology Findings and In-Life Correlates in the Nonclinical Development of Adeno-Associated Virus (AAV)-Based Retinal Gene Therapies	1
Deep Learning–Based Spermatogenic Staging in Tissue Sections of Cynomolgus Macaque Testes	1
Histology Atlas of the Developing Mouse Placenta	1
Neutropenia in Cynomolgus Monkeys With Anti-Drug Antibodies Associated With Administration of Afucosylated Humanized Monoclonal Antibodies	1
Corrigendum to Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location	1
Session 5: Protein Degraders	1
Scientific and Regulatory Policy Committee Brief Communication: 2019 Survey on Use of Digital Histopathology Systems in Nonclinical Toxicology Studies	1