OOIR: Observatory of International Research

Papers

(The median citation count of Toxicologic Pathology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Kidney Effects by Alternative Classes of Medicines in Patients and Relationship to Effects in Nonclinical Toxicity Studies	104
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman	73
A Pathologist’s Guide to Non-clinical Safety Assessment of Adoptive Cell Therapy Products	25
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies	25
Toxicity and Local Tolerance of COVID- eVax, a Plasmid DNA Vaccine for SARS-CoV-2, Delivered by Electroporation	22
Symmetric Dimethylarginine Is a Sensitive Biomarker of Glomerular Injury in Rats	18
Early-Onset Asymptomatic Polypoid Cystitis in Two Adolescent Male Beagle Dogs	18
Spontaneous Findings in the Reproductive System of Sexually Mature Male Cynomolgus Macaques	17
Guide for Combining Primary Tumors for Statistical Analysis in Rodent Carcinogenicity Studies	17
Toxicologic Pathology Forum: mRNA Vaccine Safety–Separating Fact From Fiction	16
In Utero Exposure to 3,3′,4,4′, 5-Pentachlorobiphenyl Dose-Dependently Induces N-butyl-4-(hydroxybutyl) Nitrosamine in Rats With Urinary Bladder Carcinoma	14
Retraction Notice: “Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats”	14
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies	12
Toxicologic Pathology Forum*: Opinion on Assessing and Communicating Adversity for Implantable Medical Devices	10
Scientific and Regulatory Policy Committee Points to Consider for Medical Device Implant Site Evaluation in Nonclinical Studies	10
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity	10
Artificial Intelligence in Toxicological Pathology: Quantitative Evaluation of Compound-Induced Follicular Cell Hypertrophy in Rat Thyroid Gland Using Deep Learning Models	10
Society of Toxicologic Pathology Nonhuman Primate Special Interest Group: Idiopathic Femoral Head Chondrolysis in Nonclinical Research Macaques	9
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats	9
Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology	9
Difference in the Mechanism of Iron Overload–Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats	9
Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vectors	9
Opinion on the Optimal Histologic Evaluation of the Bone Marrow in Nonclinical Toxicity Studies	8
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studi	8
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice	8

Selected Resources for Pathology Evaluation of Nonhuman Primates in Nonclinical Safety Assessment	8
Virtual Control Groups in Non-clinical Toxicity Studies: Impacts on Toxicologic Clinical Pathology Data Interpretation	8
Comparative Impact of Various Fasting Periods on the Welfare of Sprague-Dawley Rats With or Without Supplementation	7
Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry	7
Organ Weights in Relation to Age and Sex in Cynomolgus Monkeys (Macaca fascicularis)	7
Identifying Erythrocyte Injury in Toxicology Studies	7
Cardiac Rhabdomyoma in Four Göttingen Minipigs	7
Proceedings of the 2022 National Toxicology Program Satellite Symposium	6
Neurofilament Light Chain: A Translational Safety Biomarker for Drug-Induced Peripheral Neurotoxicity	6
Morphologic Features and Deep Learning–Based Analysis of Canine Spermatogenic Stages	6
Applications of Cell-Based Protein Array Technology to Preclinical Safety Assessment of Biological Products	6
Scientific and Regulatory Policy Committee Points to Consider: Biological Sample Retention From Nonclinical Toxicity Studies	5
Thank You to Reviewers	5
Safety and Performance Evaluation of Su2ura Approximation, a New Suturing Device, in Pigs	5
Toxicologic Pathology Forum: Tissue Evaluation in Nonclinical Toxicity Studies for Prophylactic Vaccines	5
Possible Cytoprotection of Low Dose Lipopolysaccharide in Rat Thioacetamide-Induced Liver Lesions, Focusing on the Analyses of Hepatic Macrophages and Autophagy	5
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure	5
Brief Synopsis: “Instruction Manual for Juvenile Clinical Pathology”	4
Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution	4
Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays	4
Bortezomib-Induced Ovarian Toxicity in Mice	4
Immunotoxicology From a Pathology Perspective: A Continuing Education Course Presented at the Annual STP Meeting in Baltimore, MD, Held June 16-19, 2024	4
Assessing the Carcinogenicity of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, in Rodents	4
Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat	4
Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies	4
An Overview of Nonclinical and Clinical Liver Toxicity Associated With AAV Gene Therapy	4
Scientific and Regulatory Policy Committee Points to Consider: Fixation, Trimming, and Sectioning of Nonrodent Eyes and Ocular Tissues for Examination in Ocular and General Toxicity Studies	3
IT/QA and Regulatory Aspects of Digital Pathology: Results of the 8th ESTP International Workshop	3
Phthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans	3
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Diving Head-First Into the Deep Digital Pool!	3
Pathological Characterization of Spontaneous AA Amyloidosis in Microminipigs	3
Proceedings of the 2021 National Toxicology Program Satellite Symposium	3
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing	3
Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey ( Macaca fascicularis )	3
Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling	3
Corrigendum to Histology Atlas of the Developing Mouse Placenta	3
Characterization of Urothelial Inclusions in Male Wistar Han Rats Treated Orally With the Novel α2A-Adrenoceptor Agonist Tasipimidine	3
Toxicologic Pathology Forum: Opinion on Approaches for Reporting Toxic and Adverse Dose Levels in Nonclinical Toxicology Studies Supporting the Development of Anticancer Pharmaceuticals	3
Effects of LRRK2 Inhibitors in Nonhuman Primates	3
Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies	3
The Impact of Functional and Structural Maturation of the Kidney on Susceptibility to Drug and Chemical Toxicity in Neonatal Rodents	3
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Are We There Yet?	3
Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies	2
Session 4: mRNA and Self-Amplifying RNA (saRNA): Opportunities for Disease Prevention and Therapy	2
Immunohistochemical Characterization of Proliferative Lesions in the Thymus of Aging CD-1 Mice From Two Studies on the RITA Database, With Special Reference to the Perivascular Space	2
Prenatal Evaluations: A Prologue to Postnatal Pathology Interpretations	2
Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice	2
Does Geographical Origin of Long-Tailed Macaques (Macaca fascicularis) Matter in Drug Safety Assessment?: A Literature Review and Proposed Conclusion	2
Special Issue on the Pathobiology of Laboratory Nonhuman Primates: A Review of Species, Substrain, Geographical Origin, Age, and Modality-Related Factors	2
Historical Control Data of Spontaneous Lesions of Laboratory New Zealand White and Dutch Belted Rabbits ( Oryctolagus Cuniculus ) Used in Toxicity Studies	2

Post-Pandemic Pathology Practice	2
Toxicologic Pathology Forum*: Opinion on New Technologies and Trends Disrupting Drug Discovery and Development: How Can the Next Generation of Toxicologic Pathologists Be Prepared for Evolving Roles?	2
Spontaneous Primary Pleural Mesothelioma in Fischer 344 (F344) and Other Rat Strains: A Retrospective Review	2
Neuropathology Evaluation in Juvenile Toxicity Studies in Rodents: Comparison of Developmental Neurotoxicity Studies for Chemicals With Juvenile Animal Studies for Pediatric Pharmaceuticals	2
Proceedings of the 2023 Annual Scientific Meeting of the French Society of Toxicologic Pathology (SFPT) on Preclinical Development and Therapeutic Applications of mRNA-Based Technologies	2
Complex In Vitro Model Characterization for Context of Use in Toxicologic Pathology: Use Cases by Collaborative Teams of Biologists, Bioengineers, and Pathologists	2
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop	2
Granulocytosis, a Paraneoplastic Syndrome Associated With Non-Glandular Squamous Cell Carcinomas (NGSCC) in the Tg.rasH2 Studies	2
Regulatory Perspectives on Juvenile Animal Toxicologic Pathology	2
To Clot or Not to Clot: Deepening Our Understanding of Alterations in the Hemostatic System	2
Proceedings of the 2024 Division of Translational Toxicology Satellite Symposium	2
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats	2
Society of Toxicologic Pathology Neuropathology Interest Group Article: Neuropathologic Findings in Nonhuman Primates Associated With Administration of Biomolecule-Based Test Articles	2
How Does Lifestyle Affect Hematopoiesis and the Bone Marrow Microenvironment?	2
Results of the European Society of Toxicologic Pathology Survey on the Use of Artificial Intelligence in Toxicologic Pathology	2
Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development	2
Use of Both Fluoro-Jade B and Hematoxylin and Eosin to Detect Cell Death in the Juvenile Rat Brain Exposed to NMDA-Receptor Antagonists or GABA-Receptor Agonists in Safety Assessment	2
Immune-Mediated Liver Effects Associated With Administration of a Human Anti-IL-21 Receptor Antibody (ATR-107) in Rats	2
Histology Atlas of the Developing Mouse Respiratory System From Prenatal Day 9.0 Through Postnatal Day 30	2
A Developmental Atlas as a Reflection of Our Professional Lifecycle	1
Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig	1
Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver	1
Pseudoreticulocytosis by the ADVIA 2120 Hematology Analyzer and Other Hematologic Changes in a Cynomolgus Macaque (Macaca fascicularis) With Malaria	1
Role for Mucin-5AC in Upper and Lower Airway Pathogenesis in Mice	1
Histology Atlas of the Developing Mouse Placenta	1
Neutropenia in Cynomolgus Monkeys With Anti-Drug Antibodies Associated With Administration of Afucosylated Humanized Monoclonal Antibodies	1
Scientific and Regulatory Policy Committee Brief Communication: 2019 Survey on Use of Digital Histopathology Systems in Nonclinical Toxicology Studies	1
Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques	1
Exogenous Growth Hormone Exacerbates Post-Irradiation Atherosclerosis in Susceptible Epicardial Coronary Arteries	1
Risk Assessment for Hepatobiliary Toxicity Liabilities in Drug Development	1
Pathology Findings and In-Life Correlates in the Nonclinical Development of Adeno-Associated Virus (AAV)-Based Retinal Gene Therapies	1
Gastric Neuroendocrine Tumors With Parietal Cell Atrophy in a Long-term Carcinogenicity Study in Rats	1
Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats	1
Myelin Methods: A Mini-Review	1
Carcinogenicity Evaluation of Baclofen in TgrasH2 Mice	1
Corrigendum to Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location	1
Obituary: Dr Gordon Charles Hard (1931-2021)	1
Extraintestinal Pathogenic Escherichia Coli Causes Necrohemorrhagic Pneumonia in Multiple Research Dogs	1
Comparison of ANP and BNP Granular Density in Atria of Rats After Physiological and Pathological Hypertrophy	1
Pathology of Bone: Changes Associated With Different Classes of Compounds	1
Session 5: Protein Degraders	1
Opinion on the Importance of Sharing Toxicologic Pathology Data for Educational and/or Scientific Purposes	1
Toxicologic Pathology Forum Opinion Piece: Use of Virtual Control Groups in Nonclinical Toxicity Studies: The Anatomic Pathology Perspective	1
Poster Abstracts of the 20^th Congress of the European Society of Toxicologic Pathology (Basel, Switzerland, 26th - 29th of September 2023, Emerging Therapeutic Modalities)	1
Molecular Pathology Methods to Characterize Biodistribution and Pharmacodynamics of the Oncolytic Virus VSV-GP in a Nonclinical Tumor Model	1
IHI VICT3R: Developing and Implementing Virtual Control Groups to Reduce Animal Use in Toxicology Research	1
Assessment of Color Reproducibility and Mitigation of Color Variation in Whole Slide Image Scanners for Toxicologic Pathology	1