OOIR: Observatory of International Research

Papers

(The median citation count of Toxicologic Pathology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Predatory Journals: What They Are and How to Avoid Them	50
Comparative Milestones in Rodent and Human Postnatal Central Nervous System Development	39
Histology Atlas of the Developing Mouse Placenta	31
A Review of Specific Biomarkers of Chronic Renal Injury and Their Potential Application in Nonclinical Safety Assessment Studies	26
Review of Current Vaccine Development Strategies to Prevent Coronavirus Disease 2019 (COVID-19)	25
Utilization of a Deep Learning Algorithm for Microscope-Based Fatty Vacuole Quantification in a Fatty Liver Model in Mice	24
DICOM Format and Protocol Standardization—A Core Requirement for Digital Pathology Success	23
IMI—Bigpicture: A Central Repository for Digital Pathology	21
Modeling SARS-CoV-2: Comparative Pathology in Rhesus Macaque and Golden Syrian Hamster Models	19
Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems: New and Revised INHAND Terms	18
Impact of Preanalytical Factors During Histology Processing on Section Suitability for Digital Image Analysis	17
HistoNet: A Deep Learning-Based Model of Normal Histology	15
International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog	15
Using Artificial Intelligence to Detect, Classify, and Objectively Score Severity of Rodent Cardiomyopathy	14
Artificial Intelligence in Toxicologic Pathology: Quantitative Evaluation of Compound-Induced Hepatocellular Hypertrophy in Rats	14
International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Minipig	14
Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vectors	14
Intrathecal sc-AAV9-CB-GFP: Systemic Distribution Predominates Following Single-Dose Administration in Cynomolgus Macaques	13
Adversity Considerations for Thyroid Follicular Cell Hypertrophy and Hyperplasia in Nonclinical Toxicity Studies: Results From the 6th ESTP International Expert Workshop	13
The Application, Challenges, and Advancement Toward Regulatory Acceptance of Digital Toxicologic Pathology: Results of the 7th ESTP International Expert Workshop (September 20-21, 2019)	12
Deep Learning-Based Spermatogenic Staging Assessment for Hematoxylin and Eosin-Stained Sections of Rat Testes	12
Microscope-Based Automated Quantification of Liver Fibrosis in Mice Using a Deep Learning Algorithm	11
Zebrafish as an Animal Model for Ocular Toxicity Testing: A Review of Ocular Anatomy and Functional Assays	11
The Common Marmoset—Biomedical Research Animal Model Applications and Common Spontaneous Diseases	10
Screening For Bone Marrow Cellularity Changes in Cynomolgus Macaques in Toxicology Safety Studies Using Artificial Intelligence Models	10

Role for Mucin-5AC in Upper and Lower Airway Pathogenesis in Mice	10
Evaluation of the Use of Single- and Multi-Magnification Convolutional Neural Networks for the Determination and Quantitation of Lesions in Nonclinical Pathology Studies	10
Developing a Qualification and Verification Strategy for Digital Tissue Image Analysis in Toxicological Pathology	10
Urinary Kidney Biomarker Panel Detects Preclinical Antisense Oligonucleotide-Induced Tubular Toxicity	9
Evaluation of 10 Urinary Biomarkers for Renal Safety With 5 Nephrotoxicants in Nonhuman Primates	9
Effects of Delgocitinib Ointment 0.5% on the Normal Mouse Skin and Epidermal Tight Junction Proteins in Comparison With Topical Corticosteroids	9
The Influence of Geographical Origin, Age, Sex, and Animal Husbandry on the Spontaneous Histopathology of Laboratory Cynomolgus Macaques (Macaca Fascicularis): A Contemporary Global and Multisi	9
Proof of Concept: The Use of Whole-Slide Images (WSI) for Peer Review of Tissues on Routine Regulatory Toxicology Studies	8
Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig	8
Histological Features of Postnatal Development of the Eye in White Rabbits	8
Nonclinical Toxicology and Biocompatibility Program Supporting Clinical Development and Registration of the Port Delivery System With Ranibizumab for Neovascular Age-Related Macular Degeneration	8
Local Tolerance and Biodegradability of a Novel Artificial Dura Mater Graft Following Implantation Onto a Dural Defect in Rabbits	8
BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics	8
Organ Weights in Relation to Age and Sex in Cynomolgus Monkeys (Macaca fascicularis)	8
Neuropathology Evaluation in Juvenile Toxicity Studies in Rodents: Comparison of Developmental Neurotoxicity Studies for Chemicals With Juvenile Animal Studies for Pediatric Pharmaceuticals	8
Nervous System Sampling for General Toxicity and Neurotoxicity Studies in Rabbits	8
Utilizing Whole Slide Images for the Primary Evaluation and Peer Review of a GLP-Compliant Rodent Toxicology Study	7
Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats	7
Opinion on Current Use of Non-Blinded Versus Blinded Histopathologic Evaluation in Animal Toxicity Studies	7
Characterization of the Nonendocrine Cell Populations in Human Embryonic Stem Cell–Derived (hESC) Islet-Like Clusters Posttransplantation	7
Review of the Technical, Toxicological, and PKPD Considerations for Conducting Inhalation Toxicity Studies on Biologic Pharmaceuticals—The Outcome of a Cross-Industry Working Group Survey	7
Aspiration and Inspiration: Using Bronchoalveolar Lavage for Toxicity Assessment	7
Long-Term Nonclinical Pulmonary Safety Assessment of Afrezza, a Novel Insulin Inhalation Powder	7
Proof of Concept for a Deep Learning Algorithm for Identification and Quantification of Key Microscopic Features in the Murine Model of DSS-Induced Colitis	7
Special Issue on Digital Pathology, Tissue Image Analysis, Artificial Intelligence, and Machine Learning: Approximation of the Effect of Novel Technologies on Toxicologic Pathology	7
Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques	7
Toxicity and Local Tolerance of a Novel Spike Protein RBD Vaccine Against SARS-CoV-2, Produced Using the C1 Thermothelomyces Heterothallica Protein Expression Platform	7
Multisite Analysis of Lesions in the Respiratory Tract of the Rat and Nonhuman Primate (Cynomolgus Monkey) Exposed to Air, Vehicle, and Inhaled Small Molecule Compounds	7
Kidney Transporters and Drug-Induced Injury in Drug Development	7
Deep Learning in Toxicologic Pathology: A New Approach to Evaluate Rodent Retinal Atrophy	7
Scientific and Regulatory Policy Committee Best Practices: Documentation of Sexual Maturity by Microscopic Evaluation in Nonclinical Safety Studies	7
Ketamine/Xylazine Anesthesia–Related Corneal Lesions in Rats With Surgically Implanted Venous Catheters Utilized in Nonclinical Intravenous Studies	7
A Workflow for the Performance of the Differential Ovarian Follicle Count Using Deep Neuronal Networks	7
Ozone Reacts With Carbon Black to Produce a Fulvic Acid-Like Substance and Increase an Inflammatory Effect	7
Mucosa-Associated Lymphoid Tissue and Tertiary Lymphoid Structures of the Eye and Ear in Laboratory Animals	6
Phthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans	6
Selected Aspects of Ocular Toxicity Studies With a Focus on High-Quality Pathology Reports: A Pathology/Toxicology Consultant’s Perspective	6
Evaluation of Rat Acute Phase Proteins as Inflammatory Biomarkers for Vaccine Nonclinical Safety Studies	6
Perspectives on Lung Dose and Inhaled Biomolecules	6
Accept or Reject: The Role of Immune Tolerance in the Development of Stem Cell Therapies and Possible Future Approaches	6
Scientific and Regulatory Policy Committee Points to Consider for Medical Device Implant Site Evaluation in Nonclinical Studies	6
Spontaneous Axonal Dystrophy in the Brain and Spinal Cord in Naïve Beagle Dogs	6
Antisense Oligonucleotide-Related Macrovesicular Vacuolation of Hippocampal Neurons in Nonhuman Primates	6
Using Deep Learning Artificial Intelligence Algorithms to Verify N-Nitroso-N-Methylurea and Urethane Positive Control Proliferative Changes in Tg-RasH2 Mouse Carcinogenicity Studies	6
The MNU Plus Testosterone Rat Model of Prostate Carcinogenesis	6
Mini Review: The Last Mile—Opportunities and Challenges for Machine Learning in Digital Toxicologic Pathology	6
Society of Toxicologic Pathology Neuropathology Interest Group Article: Neuropathologic Findings in Nonhuman Primates Associated With Administration of Biomolecule-Based Test Articles	6
Transmission Electron Microscopy of the Retina: A Method for Sample Preparation and Evaluation	6
Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity	5
Anatomic and Clinical Pathology Characterization of Drug-Induced Sinusoidal Obstruction Syndrome (Veno-Occlusive Disease) in Cynomolgus Macaques	5

Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies	5
Foreign Body Reaction, Retinal Degeneration, and Epiretinal Membranes Associated With Intravitreal Administration of PLGA Rods	5
Implementation and Practice of Deep Learning-Based Instance Segmentation Algorithm for Quantification of Hepatic Fibrosis at Whole Slide Level in Sprague-Dawley Rats	5
The Impact of the Timing of Dosing on the Severity of UNC569-Induced Ultrastructural Changes in the Mouse Retina	5
A Technical Guide to Sampling the Beagle Dog Nervous System for General Toxicity and Neurotoxicity Studies	5
A Critical Review of Morphologic Findings and Data From 14 Toxicological Studies Involving Fish Exposures to Diclofenac	5
Opinion on Performing Pathology Peer-Review During the Global Pandemic: Challenges and Opportunities	5
Toxicity and Local Tolerance of COVID- eVax, a Plasmid DNA Vaccine for SARS-CoV-2, Delivered by Electroporation	5
Appearance of Heterogeneous Macrophages During Development of Isoproterenol-Induced Rat Myocardial Fibrosis	4
Biomarker-Based Classification and Localization of Renal Lesions Using Learned Representations of Histology—A Machine Learning Approach to Histopathology	4
Artificial Intelligence-Based Quantification of Epithelial Proliferation in Mammary Glands of Rats and Oviducts of Göttingen Minipigs	4
Biologic Immunomodulatory Drugs and Infection in the Respiratory Tract of Nonhuman Primates	4
Immunology and Pathology in Ocular Drug Development	4
Qualitative and Quantitative Neuropathology Approaches Using Magnetic Resonance Microscopy (Diffusion Tensor Imaging) and Stereology in a Hexachlorophene Model of Myelinopathy in Sprague-Dawley Rats	4
Scientific and Regulatory Policy Committee Points to Consider: Fixation, Trimming, and Sectioning of Nonrodent Eyes and Ocular Tissues for Examination in Ocular and General Toxicity Studies	4
Perspective on Adversity in Toxicology Evaluations	4
Incidences and Range of Spontaneous Microscopic Lesions in the Eye of Sprague-Dawley Rats and Han Wistar Rats Used in Toxicity Studies	4
Phosphatidylinositol 3-Kinase δ Inhibitor-Induced Immunomodulation and Secondary Opportunistic Infection in the Cynomolgus Monkey (Macaca fascicularis)	4
Selective Chemonucleolysis With Condoliase in Cynomolgus Monkeys	4
Quantitative Assessment of Neuroinflammation, Myelinogenesis, Demyelination, and Nerve Fiber Regeneration in Immunostained Sciatic Nerves From Twitcher Mice With a Tissue Image Analysis Platform	4
Opinion on Immune Tolerance Therapeutic Development	4
D-PLEX₁₀₀ in an Abdominal Surgery Incision Model in Miniature Swine: Safety Study	4
Observation of Silicone Oil Within the Vitreous and Sclera Following Intravitreal Administration of Biotherapeutics Using Insulin Syringes in Cynomolgus Monkeys	4
Neurofilament Light Chain: A Translational Safety Biomarker for Drug-Induced Peripheral Neurotoxicity	3
Regulatory Perspectives on Juvenile Animal Toxicologic Pathology	3
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studi	3
Comparison of ANP and BNP Granular Density in Atria of Rats After Physiological and Pathological Hypertrophy	3
An Overview of Nonclinical and Clinical Liver Toxicity Associated With AAV Gene Therapy	3
Semiquantitative Methods for GFP Immunohistochemistry and In Situ Hybridization to Evaluate AAV Transduction of Mouse Retinal Cells Following Subretinal Injection	3
Identifying Erythrocyte Injury in Toxicology Studies	3
Nonclinical Safety Assessment of an Inhaled Formulation of Serelaxin: A Recombinant Human Protein in Rats and Cynomolgus Monkeys (Macaca fascicularis)	3
Neuroanatomy and Sampling of Central Projections for the Visual System in Mammals Used in Toxicity Testing	3
Preclinical Safety Assessment of 2 Inhaled Single-Domain Antibodies in the Cynomolgus Monkey	3
Furan Induced Characteristic Glutathione S-Transferase Placental Form-Positive Foci in Terms of Cell Kinetics and Gene Expression	3
Opinion on the Use of Animal Models in Nonclinical Safety Assessment: Pros and Cons	3
Proteomic Analysis of Subchronic Furan Exposure in the Liver of Male Fischer F344 Rats	3
Scientific and Regulatory Policy Committee Brief Communication: 2019 Survey on Use of Digital Histopathology Systems in Nonclinical Toxicology Studies	3
Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats	3
Assessment of Mouse Liver Histopathology Following Exposure to HFPO-DA With Emphasis on Understanding Mechanisms of Hepatocellular Death	3
Pharmacobezoar Formation From HPMC-AS-Containing Spray-Dried Formulations in Nonclinical Safety Studies in Rats	3
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies	3
Inhalation of Silver Silicate Nanoparticles Leads to Transient and Differential Microglial Activation in the Rodent Olfactory Bulb	2
Evaluation of Adrenal Cortical Function in Neonatal and Weanling Laboratory Beagle Dogs	2
Does Geographical Origin of Long-Tailed Macaques (Macaca fascicularis) Matter in Drug Safety Assessment?: A Literature Review and Proposed Conclusion	2
Zucker Lean Rats With Hepatic Steatosis Recapitulate Asymptomatic Metabolic Syndrome and Exhibit Greater Sensitivity to Drug-Induced Liver Injury Compared With Standard Nonclinical Sprague-Dawley Rat	2
Tolerability Assessment of Formulation pH in New Zealand White Rabbits Following Intravitreal Administration	2
Intravitreal Administration of Acetyl Triethyl Citrate and Benzyl Benzoate Is Retinotoxic in Rabbits but Not in Cynomolgus Monkeys	2
The Impact of Functional and Structural Maturation of the Kidney on Susceptibility to Drug and Chemical Toxicity in Neonatal Rodents	2
Artificial Intelligence in Toxicological Pathology: Quantitative Evaluation of Compound-Induced Follicular Cell Hypertrophy in Rat Thyroid Gland Using Deep Learning Models	2
Spontaneous Background and Procedure-Related Microscopic Findings and Common Artifacts in Ocular Tissues of Laboratory Animals in Ocular Studies	2
Spontaneous Findings in the Reproductive System of Sexually Mature Male Cynomolgus Macaques	2
Spontaneous Primary Pleural Mesothelioma in Fischer 344 (F344) and Other Rat Strains: A Retrospective Review	2
Inspiration and Exasperation: The Challenges of Inhaled Biologics	2
Proceedings of the 2021 National Toxicology Program Satellite Symposium	2
Mammalian Retinal Cell Quantification	2
Possible Cytoprotection of Low Dose Lipopolysaccharide in Rat Thioacetamide-Induced Liver Lesions, Focusing on the Analyses of Hepatic Macrophages and Autophagy	2
Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy	2
Thresholds Derived From Common Measures in Rat Studies Are Predictive of Liver Tumorigenic Chemicals	2
Evaluation of a Model of Long-Term Middle Ear Catheterization for Repeat Infusion Administration and Cochlear Hair Cell Injury in Guinea Pigs	2
Characterization of Spontaneous Vascular Findings in the Papillary Muscles of Beagle Dogs	2
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics	2
Degenerative Myelopathy and Neuropathy in NOD.Cg-Prkdc^scidIl2rg^tm1Wjl/SzJ (NSG) Mice Caused by Lactate Dehydrogenase–Elevating Virus (LDV)	2