OOIR: Observatory of International Research

Papers

(The median citation count of Toxicologic Pathology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies	52
Early-Onset Asymptomatic Polypoid Cystitis in Two Adolescent Male Beagle Dogs	27
Guide for Combining Primary Tumors for Statistical Analysis in Rodent Carcinogenicity Studies	24
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman	22
A Pathologist’s Guide to Non-clinical Safety Assessment of Adoptive Cell Therapy Products	17
Comparative Study of Chemically Induced Renal Mesenchymal and Mammary Tumors in Female Sprague-Dawley and Wistar Rats	15
Thymic Epithelial Hyperplasia and Thymoma in Control rasH2 Transgenic Mice From 26-Week Carcinogenicity Assays	14
Time-Dependent Autolysis in Ex Vivo–Maintained Rat Tissue in Saline: A Descriptive Study and Practical Guidance for Histopathologic Assessment	13
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies	12
Toxicologic Pathology Forum*: Opinion on Assessing and Communicating Adversity for Implantable Medical Devices	12
Retraction Notice: “Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats”	12
Spontaneous Abdominal Hemangiosarcoma With Metastases to the Lungs in a Control Sprague-Dawley Rat	11
Toxicologic Pathology Forum: mRNA Vaccine Safety–Separating Fact From Fiction	11
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats	10
Neuro Omics: Translational Neuropathology Applications of Spatial Technologies From Nonclinical Models to Human Disease	10
Hemangiosarcomas in Intercostal Brown Adipose Tissues of the Sternum Induced by Urethane in TgrasH2 Mice	9
Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology	9
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity	9
Difference in the Mechanism of Iron Overload–Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats	9
Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies	9
Comparative Impact of Various Fasting Periods on the Welfare of Sprague-Dawley Rats With or Without Supplementation	8
Injection-Site Sarcomas in Rodent Carcinogenicity Studies: Human Relevance and Labeling Implications	8
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice	8
Placental Lesions in CD-1 Mouse Placenta Following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)	8
Navigating the Pathology Minefield: Harnessing the Value of Historical Control Data in Rodent Carcinogenicity Studies	8

Oligonucleotides: Evolution of Carcinogenicity and Risk Assessment Strategy	8
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studi	8
Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry	7
Adeno-Associated Virus Gene Therapy: Is There a Risk of Insertional Mutagenesis?	7
Neurofilament Light Chain: A Translational Safety Biomarker for Drug-Induced Peripheral Neurotoxicity	7
Virtual Control Groups in Non-clinical Toxicity Studies: Impacts on Toxicologic Clinical Pathology Data Interpretation	7
Cardiac Rhabdomyoma in Four Göttingen Minipigs	7
Scientific and Regulatory Policy Committee Points to Consider*: Sample Selection, Assay Design, Data Generation and Interpretation, and Reporting Practices for Chromogenic Immunohistochemical (IHC) As	7
Proceedings of the 2024 Classic Examples in Toxicologic Pathology XXXI	6
Applications of Cell-Based Protein Array Technology to Preclinical Safety Assessment of Biological Products	6
Transmission Electron Microscopy of the Peripheral Nervous System: Methods, Sample Preparation, and Case Studies	6
Pathophysiology of Ischemic Cell Death in the Central Nervous System	6
New Approach Methodologies (NAMs) for Carcinogenicity Evaluation	6
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure	5
Proceedings of the 2022 National Toxicology Program Satellite Symposium	5
Morphologic Features and Deep Learning–Based Analysis of Canine Spermatogenic Stages	5
Identifying Erythrocyte Injury in Toxicology Studies	5
Thank You to Reviewers	5
Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution	4
Reliable Identification of Alpha2u-Globulin and Lysozyme Accumulation in Rat Kidney by Label-Free MALDI Mass Spectrometry Imaging	4
An Overview of Nonclinical and Clinical Liver Toxicity Associated With AAV Gene Therapy	4
Immunotoxicology From a Pathology Perspective: A Continuing Education Course Presented at the Annual STP Meeting in Baltimore, MD, Held June 16-19, 2024	4
Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies	4
Red Deads, Ghosts, and the Afterlife: A Guide to Neuronal Cell Death	4
Deep Learning Methodology for Quantification of Normal Pancreas Structures	4
Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies	4
Assessing the Carcinogenicity of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, in Rodents	4
Toxicologic Pathology Forum: Tissue Evaluation in Nonclinical Toxicity Studies for Prophylactic Vaccines	4
Post-Pandemic Pathology Practice	3
Toxicologic Pathology Forum: Opinion on Approaches for Reporting Toxic and Adverse Dose Levels in Nonclinical Toxicology Studies Supporting the Development of Anticancer Pharmaceuticals	3
Toxicologic Pathology Forum*: Opinion on the Future of Histopathology Using Whole Slide Images in Toxicologic Pathology of Preclinical Studies and Its Successful Implementation in Compliance With Good	3
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Diving Head-First Into the Deep Digital Pool!	3
Pathological Characterization of Spontaneous AA Amyloidosis in Microminipigs	3
Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies	3
Toxicologic Pathology Forum*: Opinion on Qualitative Severity Descriptors to Express Magnitude of Changes in Clinical Pathology Endpoints in Nonclinical Toxicity Studies	3
To Clot or Not to Clot: Deepening Our Understanding of Alterations in the Hemostatic System	3
Toxicologic Pathology Forum*: Opinion on Remote Digital Toxicologic Pathology in Practice—Lessons From a Digital Team and Approach to Scientific Quality, Flexibility, and Well-Being	3
Effects of LRRK2 Inhibitors in Nonhuman Primates	3
Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey ( Macaca fascicularis )	3
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing	3
IT/QA and Regulatory Aspects of Digital Pathology: Results of the 8th ESTP International Workshop	3
Histology Atlas of the Developing Mouse Respiratory System From Prenatal Day 9.0 Through Postnatal Day 30	3
Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System: Revised INHAND Terms for Ovarian Sex Cord/Stromal Lesions	3
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Are We There Yet?	3
Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies	3
Corrigendum to Histology Atlas of the Developing Mouse Placenta	3
Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays	3
Absolute Versus Relative Approaches to Severity Scoring of Histopathologic Findings in Pre-Clinical Toxicology Studies: What’s the Difference, and How, When, and Why This Matters	3
Toxicologic Pathology Forum*: Opinion on New Technologies and Trends Disrupting Drug Discovery and Development: How Can the Next Generation of Toxicologic Pathologists Be Prepared for Evolving Roles?	3
Immune-Mediated Liver Effects Associated With Administration of a Human Anti-IL-21 Receptor Antibody (ATR-107) in Rats	3

Meeting Report Session 3: Neurobiomarkers STP 44th Annual Symposium 2025 Development and Utility of Neurobiomarkers in Nonclinical Toxicology Studies	3
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop	2
Results of the European Society of Toxicologic Pathology Survey on the Use of Artificial Intelligence in Toxicologic Pathology	2
A Fandango of Form and Function: The Interplay Between Clinical Neurology and Neuropathology Evaluation	2
Complex In Vitro Model Characterization for Context of Use in Toxicologic Pathology: Use Cases by Collaborative Teams of Biologists, Bioengineers, and Pathologists	2
2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives	2
Proceedings of the 2024 Division of Translational Toxicology Satellite Symposium	2
Session 4: mRNA and Self-Amplifying RNA (saRNA): Opportunities for Disease Prevention and Therapy	2
Second Joint Annual Congress of the British Society of Toxicologic Pathology and the European Society of Toxicologic Pathology Special Issue	2
Digital Pathology and Artificial Intelligence Applied to Nonclinical Toxicology Pathology—The Current State, Challenges, and Future Directions	2
How Does Lifestyle Affect Hematopoiesis and the Bone Marrow Microenvironment?	2
Neuropathology and Biomarker Correlates of Late Onset Alzheimer’s Disease in Aged Old World Monkeys	2
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats	2
An Introduction to the Society of Toxicologic Pathology’s 44th Annual Symposium on Toxicologic Neuropathology: Basics and Beyond	2
Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development	2
No Clear Evidence of Histopathological Effects Linked to NSAIDs in the Kidney or Liver of Fish Exposed to Treated Municipal Wastewaters	2
Carcinogenicity in the 21st Century: Data Interpretation—Session 4	2
Proceedings of the 2023 Annual Scientific Meeting of the French Society of Toxicologic Pathology (SFPT) on Preclinical Development and Therapeutic Applications of mRNA-Based Technologies	2
Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice	2
STP Town Hall Discussion on the Use of Virtual Control Groups in Nonclinical Toxicity Studies	2
Historical Control Data of Spontaneous Lesions of Laboratory New Zealand White and Dutch Belted Rabbits ( Oryctolagus Cuniculus ) Used in Toxicity Studie	2
Thank You to Reviewers	2
Assessment of Color Reproducibility and Mitigation of Color Variation in Whole Slide Image Scanners for Toxicologic Pathology	1
Exogenous Growth Hormone Exacerbates Post-Irradiation Atherosclerosis in Susceptible Epicardial Coronary Arteries	1
Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery	1
Book Review: Toxicologic Pathology for Non-Pathologists	1
Risdiplam: A Small Molecule mRNA Splice Modifier Approved to Treat SMA Disease	1
Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver	1
Hot Topics, Future Directions, and Challenges Faced in Toxicologic Neuropathology	1
Non-Protein-Coding RNA Instability in the Human Postmortem Brain	1
A Developmental Atlas as a Reflection of Our Professional Lifecycle	1
Pathology of Bone: Changes Associated With Different Classes of Compounds	1
Session 5: Protein Degraders	1
Corrigendum to Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location	1
Neutropenia in Cynomolgus Monkeys With Anti-Drug Antibodies Associated With Administration of Afucosylated Humanized Monoclonal Antibodies	1
Myelin Methods: A Mini-Review	1
Molecular Pathology Methods to Characterize Biodistribution and Pharmacodynamics of the Oncolytic Virus VSV-GP in a Nonclinical Tumor Model	1
Toxicologic Pathology Forum Opinion Piece: Use of Virtual Control Groups in Nonclinical Toxicity Studies: The Anatomic Pathology Perspective	1
Enhanced Detection of Methyl Methanesulfonate–Induced Sperm Lesions in Rats Using Laser Scanning Microscopy	1
Extraintestinal Pathogenic Escherichia Coli Causes Necrohemorrhagic Pneumonia in Multiple Research Dogs	1
Poster Abstracts of the 20 ^th Congress of the European Society of Toxicologic Pathology (Basel, Switzerland, 26th - 29th of September 2023, Emerging	1
Pathology Findings and In-Life Correlates in the Nonclinical Development of Adeno-Associated Virus (AAV)-Based Retinal Gene Therapies	1
Thyroid Hormone Imbalance in Pregnant Rats and its Impact on Neurodevelopment in Pups: A Minireview on Histopathological Endpoints	1
Risk Assessment for Hepatobiliary Toxicity Liabilities in Drug Development	1
Microscopic Findings in Seminal Vesicles of Control Rats Mated to Females From Fertility and Early Embryonic Development Studies	1
IHI VICT3R: Developing and Implementing Virtual Control Groups to Reduce Animal Use in Toxicology Research	1