OOIR: Observatory of International Research

Papers

(The median citation count of Toxicologic Pathology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Guide for Combining Primary Tumors for Statistical Analysis in Rodent Carcinogenicity Studies	47
Thymic Epithelial Hyperplasia and Thymoma in Control rasH2 Transgenic Mice From 26-Week Carcinogenicity Assays	36
Kidney Effects by Alternative Classes of Medicines in Patients and Relationship to Effects in Nonclinical Toxicity Studies	28
A Pathologist’s Guide to Non-clinical Safety Assessment of Adoptive Cell Therapy Products	24
Early-Onset Asymptomatic Polypoid Cystitis in Two Adolescent Male Beagle Dogs	24
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman	20
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies	18
Toxicologic Pathology Forum*: Opinion on Assessing and Communicating Adversity for Implantable Medical Devices	16
Comparative Study of Chemically Induced Renal Mesenchymal and Mammary Tumors in Female Sprague-Dawley and Wistar Rats	16
Toxicologic Pathology Forum: mRNA Vaccine Safety–Separating Fact From Fiction	15
Retraction Notice: “Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats”	14
Neuro Omics: Translational Neuropathology Applications of Spatial Technologies From Nonclinical Models to Human Disease	13
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies	13
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats	13
Scientific and Regulatory Policy Committee Points to Consider for Medical Device Implant Site Evaluation in Nonclinical Studies	12
Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology	11
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity	11
Difference in the Mechanism of Iron Overload–Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats	11
Spontaneous Abdominal Hemangiosarcoma With Metastases to the Lungs in a Control Sprague-Dawley Rat	11
Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies	9
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studi	9
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice	9
Virtual Control Groups in Non-clinical Toxicity Studies: Impacts on Toxicologic Clinical Pathology Data Interpretation	8
Cardiac Rhabdomyoma in Four Göttingen Minipigs	8
Oligonucleotides: Evolution of Carcinogenicity and Risk Assessment Strategy	8

Comparative Impact of Various Fasting Periods on the Welfare of Sprague-Dawley Rats With or Without Supplementation	8
Scientific and Regulatory Policy Committee Points to Consider*: Sample Selection, Assay Design, Data Generation and Interpretation, and Reporting Practices for Chromogenic Immunohistochemical (IHC) As	8
Navigating the Pathology Minefield: Harnessing the Value of Historical Control Data in Rodent Carcinogenicity Studies	8
Neurofilament Light Chain: A Translational Safety Biomarker for Drug-Induced Peripheral Neurotoxicity	7
Pathophysiology of Ischemic Cell Death in the Central Nervous System	7
Applications of Cell-Based Protein Array Technology to Preclinical Safety Assessment of Biological Products	7
Proceedings of the 2024 Classic Examples in Toxicologic Pathology XXXI	7
Identifying Erythrocyte Injury in Toxicology Studies	7
Thank You to Reviewers	7
Transmission Electron Microscopy of the Peripheral Nervous System: Methods, Sample Preparation, and Case Studies	7
Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry	7
Deep Learning Methodology for Quantification of Normal Pancreas Structures	6
Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies	6
An Overview of Nonclinical and Clinical Liver Toxicity Associated With AAV Gene Therapy	6
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure	6
Morphologic Features and Deep Learning–Based Analysis of Canine Spermatogenic Stages	6
Toxicologic Pathology Forum: Tissue Evaluation in Nonclinical Toxicity Studies for Prophylactic Vaccines	6
Proceedings of the 2022 National Toxicology Program Satellite Symposium	6
Immunotoxicology From a Pathology Perspective: A Continuing Education Course Presented at the Annual STP Meeting in Baltimore, MD, Held June 16-19, 2024	6
Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey ( Macaca fascicularis )	5
Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution	5
Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies	5
Reliable Identification of Alpha2u-Globulin and Lysozyme Accumulation in Rat Kidney by Label-Free MALDI Mass Spectrometry Imaging	5
Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies	5
Assessing the Carcinogenicity of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, in Rodents	5
IT/QA and Regulatory Aspects of Digital Pathology: Results of the 8th ESTP International Workshop	4
Red Deads, Ghosts, and the Afterlife: A Guide to Neuronal Cell Death	4
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Diving Head-First Into the Deep Digital Pool!	4
Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays	4
Toxicologic Pathology Forum*: Opinion on New Technologies and Trends Disrupting Drug Discovery and Development: How Can the Next Generation of Toxicologic Pathologists Be Prepared for Evolving Roles?	4
Toxicologic Pathology Forum*: Opinion on the Future of Histopathology Using Whole Slide Images in Toxicologic Pathology of Preclinical Studies and Its Successful Implementation in Compliance With Good	4
Corrigendum to Histology Atlas of the Developing Mouse Placenta	4
Effects of LRRK2 Inhibitors in Nonhuman Primates	4
Post-Pandemic Pathology Practice	3
Pathological Characterization of Spontaneous AA Amyloidosis in Microminipigs	3
Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies	3
Special Issue on the Pathobiology of Laboratory Nonhuman Primates: A Review of Species, Substrain, Geographical Origin, Age, and Modality-Related Factors	3
Meeting Report Session 3: Neurobiomarkers STP 44th Annual Symposium 2025 Development and Utility of Neurobiomarkers in Nonclinical Toxicology Studies	3
Proceedings of the 2024 Division of Translational Toxicology Satellite Symposium	3
Historical Control Data of Spontaneous Lesions of Laboratory New Zealand White and Dutch Belted Rabbits ( Oryctolagus Cuniculus ) Used in Toxicity Studies	3
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing	3
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Are We There Yet?	3
Toxicologic Pathology Forum: Opinion on Approaches for Reporting Toxic and Adverse Dose Levels in Nonclinical Toxicology Studies Supporting the Development of Anticancer Pharmaceuticals	3
To Clot or Not to Clot: Deepening Our Understanding of Alterations in the Hemostatic System	3
Session 4: mRNA and Self-Amplifying RNA (saRNA): Opportunities for Disease Prevention and Therapy	3
2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives	3
Thank You to Reviewers	3
Toxicologic Pathology Forum*: Opinion on Qualitative Severity Descriptors to Express Magnitude of Changes in Clinical Pathology Endpoints in Nonclinical Toxicity Studies	3
Histology Atlas of the Developing Mouse Respiratory System From Prenatal Day 9.0 Through Postnatal Day 30	3
Immune-Mediated Liver Effects Associated With Administration of a Human Anti-IL-21 Receptor Antibody (ATR-107) in Rats	3

Toxicologic Pathology Forum*: Opinion on Remote Digital Toxicologic Pathology in Practice—Lessons From a Digital Team and Approach to Scientific Quality, Flexibility, and Well-Being	3
Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System: Revised INHAND Terms for Ovarian Sex Cord/Stromal Lesions	3
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats	3
How Does Lifestyle Affect Hematopoiesis and the Bone Marrow Microenvironment?	2
Proceedings of the 2023 Annual Scientific Meeting of the French Society of Toxicologic Pathology (SFPT) on Preclinical Development and Therapeutic Applications of mRNA-Based Technologies	2
Carcinogenicity in the 21st Century: Data Interpretation—Session 4	2
Comparison of ANP and BNP Granular Density in Atria of Rats After Physiological and Pathological Hypertrophy	2
Exogenous Growth Hormone Exacerbates Post-Irradiation Atherosclerosis in Susceptible Epicardial Coronary Arteries	2
No Clear Evidence of Histopathological Effects Linked to NSAIDs in the Kidney or Liver of Fish Exposed to Treated Municipal Wastewaters	2
A Developmental Atlas as a Reflection of Our Professional Lifecycle	2
Complex In Vitro Model Characterization for Context of Use in Toxicologic Pathology: Use Cases by Collaborative Teams of Biologists, Bioengineers, and Pathologists	2
Society of Toxicologic Pathology Neuropathology Interest Group Article: Neuropathologic Findings in Nonhuman Primates Associated With Administration of Biomolecule-Based Test Articles	2
Non-Protein-Coding RNA Instability in the Human Postmortem Brain	2
Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development	2
Results of the European Society of Toxicologic Pathology Survey on the Use of Artificial Intelligence in Toxicologic Pathology	2
Extraintestinal Pathogenic Escherichia Coli Causes Necrohemorrhagic Pneumonia in Multiple Research Dogs	2
Pathology of Bone: Changes Associated With Different Classes of Compounds	2
Neuropathology and Biomarker Correlates of Late Onset Alzheimer’s Disease in Aged Old World Monkeys	2
An Introduction to the Society of Toxicologic Pathology’s 44th Annual Symposium on Toxicologic Neuropathology: Basics and Beyond	2
A Fandango of Form and Function: The Interplay Between Clinical Neurology and Neuropathology Evaluation	2
STP Town Hall Discussion on the Use of Virtual Control Groups in Nonclinical Toxicity Studies	2
Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery	2
Enhanced Detection of Methyl Methanesulfonate–Induced Sperm Lesions in Rats Using Laser Scanning Microscopy	2
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop	2
Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice	2
Does Geographical Origin of Long-Tailed Macaques (Macaca fascicularis) Matter in Drug Safety Assessment?: A Literature Review and Proposed Conclusion	2
Digital Pathology and Artificial Intelligence Applied to Nonclinical Toxicology Pathology—The Current State, Challenges, and Future Directions	2
Applications of Molecular Pathology: An Evolving Approach to Toxicologic Pathology	1
Toxicologic Pathology Forum Opinion Piece: Use of Virtual Control Groups in Nonclinical Toxicity Studies: The Anatomic Pathology Perspective	1
Neutropenia in Cynomolgus Monkeys With Anti-Drug Antibodies Associated With Administration of Afucosylated Humanized Monoclonal Antibodies	1
Thyroid Hormone Imbalance in Pregnant Rats and its Impact on Neurodevelopment in Pups: A Minireview on Histopathological Endpoints	1
Poster Abstracts of the 20^th Congress of the European Society of Toxicologic Pathology (Basel, Switzerland, 26th - 29th of September 2023, Emerging Therapeutic Modalities)	1
Book Review: Toxicologic Pathology for Non-Pathologists	1
Microscopic Findings in Seminal Vesicles of Control Rats Mated to Females From Fertility and Early Embryonic Development Studies	1
Mitigating Nephrotoxicity Risks and Ranking Drug Candidates Using MALDI Mass Spectrometry Imaging: A Case Study	1
Gastric Neuroendocrine Tumors With Parietal Cell Atrophy in a Long-term Carcinogenicity Study in Rats	1
Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver	1
Corrigendum to Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location	1
Molecular Pathology Methods to Characterize Biodistribution and Pharmacodynamics of the Oncolytic Virus VSV-GP in a Nonclinical Tumor Model	1
IHI VICT3R: Developing and Implementing Virtual Control Groups to Reduce Animal Use in Toxicology Research	1
Risk Assessment for Hepatobiliary Toxicity Liabilities in Drug Development	1
Deep Learning–Based Spermatogenic Staging in Tissue Sections of Cynomolgus Macaque Testes	1
A Technical Guide to Sampling the Beagle Dog Nervous System for General Toxicity and Neurotoxicity Studies	1
Safety Findings of Dosing Gene Therapy Vectors in NHP With Pre-existing or Treatment-Emergent Anti-capsid Antibodies	1
Opinion on the Importance of Sharing Toxicologic Pathology Data for Educational and/or Scientific Purposes	1
Pathology Findings and In-Life Correlates in the Nonclinical Development of Adeno-Associated Virus (AAV)-Based Retinal Gene Therapies	1
Myelin Methods: A Mini-Review	1
Risdiplam: A Small Molecule mRNA Splice Modifier Approved to Treat SMA Disease	1
Assessment of Color Reproducibility and Mitigation of Color Variation in Whole Slide Image Scanners for Toxicologic Pathology	1
Session 5: Protein Degraders	1
Inter-Rater and Intra-Rater Agreement in Scoring Severity of Rodent Cardiomyopathy and Relation to Artificial Intelligence–Based Scoring	1
Hot Topics, Future Directions, and Challenges Faced in Toxicologic Neuropathology	1
Toxicologic Pathology Forum*: Opinion on Addressing Gaps in INHAND Terminology for Medical Devices—A Proposal to Add New Diagnostic Nomenclature	1