American Journal of Chinese Medicine

Article	Citations
Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer’s Disease Based on Network Pharmacology and Experimental Validation	47
Proapoptotic Effect of Icariin on Human Ovarian Cancer Cells via the NF-κB/PI3K-AKT Signaling Pathway: A Network Pharmacology-Directed Experimental Investigation	42
Multiple Mechanistic Models Reveal the Neuroprotective Effects of Diterpene Ginkgolides against Astrocyte-Mediated Demyelination via the PAF-PAFR Pathway	41
Ginsenoside Rg5: A Review of Anticancer and Neuroprotection with Network Pharmacology Approach	38
Cancer Pain Management with Traditional Chinese Medicine: Current Status and Future Perspectives	34
Chinese Medicine for Coronavirus Disease 2019 (COVID-19): A GRADE-Assessed Systematic Review and Meta-Analysis	33
Ruscogenin Alleviates Myocardial Ischemia via Myosin IIA-Dependent Mitochondrial Fusion and Fission Balance	33
Tangeretin Synergizes with 5-Fluorouracil to Induce Autophagy through MicroRNA-21 in Colorectal Cancer Cells	26
Curcumin Analog L48H37 Induces Apoptosis in Human Oral Cancer Cells by Activating Caspase Cascades and Downregulating the Inhibitor of Apoptosis Proteins through JNK/p38 Signaling	22
Insight of Chinese Herbal Medicine in Treating Osteoporosis: Achievements from 2013 to 2023	20
Protective Effects and Therapeutics of Ginsenosides for Improving Endothelial Dysfunction: From Therapeutic Potentials, Pharmaceutical Developments to Clinical Trials	20
Chinese Medicine-Derived Salvianolic Acid B for Disease Therapy: A Scientometric Study	20
Ginsenoside Rg5 Improves Sleep by Regulating Energy Metabolism in Sleep-Deprived Rats	19
Advances in the Application of Traditional Chinese Medicine Using Artificial Intelligence: A Review	18
Polyphenols from Chinese Herbal Medicine: Molecular Mechanisms and Therapeutic Targets in Pulmonary Fibrosis	18
A Clinical Study on the Relationship Among Insomnia, Tongue Diagnosis, and Oral Microbiome	17
Review on Processing Methods of Toxic Chinese Materia Medica and the Related Mechanisms of Action	17
Umbelliferone Inhibits Migration, Invasion and Inflammation of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Relieves Adjuvant-Induced Arthritis in Rats by Blockade of Wnt/β-Catenin Signaling	17
The Leaves of Cyclocarya paliurus: A Functional Tea with Preventive and Therapeutic Potential of Type 2 Diabetes	16
Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism	15
ERRATUM — The Effects of Patchouli Alcohol on Diarrhea-Predominant Irritable Bowel Syndrome are Correlated with Phenotypic Plasticity in Myenteric Neurons and the Targeted Regulation of Myosin Va	15
Development and Application of Traditional Chinese Medicine Using AI Machine Learning and Deep Learning Strategies	13
Sophora alopecuroides Alleviates Neuroinflammation and Oxidative Damage of Parkinson’s Disease In Vitro and In Vivo	13
Chinese Materia Medica in Treating Depression: The Role of Intestinal Microenvironment	13
Comprehensive Exploration of the Neuroprotective Mechanisms of Ginkgo biloba Leaves in Treating Neurological Disorders	13

Ursolic Acid Inhibits Glycolysis of Ovarian Cancer via KLF5/PI3K/AKT Signaling Pathway	13
Berberine Alleviates Ischemic Brain Injury by Enhancing Autophagic Flux via Facilitation of TFEB Nuclear Translocation	13
The Effectiveness of Acupuncture for Low Back Pain: An Umbrella Review and Meta-Analysis	13
Efficacy and Mechanisms of Natural Products as Therapeutic Interventions for Chronic Respiratory Diseases	13
Wogonin Diminishes Radioresistance of Breast Cancer via Inhibition of the Nrf2/HIF-1α Pathway	13
Pharmacological Effects of a Ginseng-Containing Chinese Medicine Formula in Treating Hepatocellular Carcinoma Based on Comprehensive Bioinformatics and Experimental Validation	12
Cardioprotective Effects of Tetrahydropalmatine on Acute Myocardial Infarction in Rats	12
Progress of Chinese Medicine in Regulating Microglial Polarization against Alzheimer’s Disease	12
Regulatory Effects of Quercetin on Bone Homeostasis: Research Updates and Future Perspectives	12
Effects and Mechanistic Role of Mulberry Leaves in Treating Diabetes and its Complications	11
A Systemic Review for Ethnopharmacological Studies onIsatis indigoticaFortune: Bioactive Compounds and their Therapeutic Insights	11
Solasonine Inhibits Cancer Stemness and Metastasis by Modulating Glucose Metabolism via Wnt/β-Catenin/Snail Pathway in Osteosarcoma	11
Schisandrin a Ameliorates Cardiac Injury and Dysfunction Induced by Hemorrhagic Shock via Activating the Nrf2 Signaling Pathway	11
The Effects of Cinobufagin on Hepatocellular Carcinoma Cells Enhanced by MRT68921, an Autophagy Inhibitor	11
Berberine Attenuates Hyperuricemia by Regulating Urate Transporters and Gut Microbiota	11
Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis	10
Ginsenoside Rd Inhibited Ferroptosis to Alleviate CCl4-Induced Acute Liver Injury in Mice via cGAS/STING Pathway	10
Astragalus membranaceus Polysaccharide Regulates Small Intestinal Microbes and Activates IL-22 Signal Pathway to Promote Intestinal Stem Cell Regeneration in Aging Mice	10
Therapeutic Potential of Traditional Chinese Medicine Against Osteoarthritis: Targeting the Wnt Signaling Pathway	10
Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway	10
Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-κB Pathways	10
Pharmacological Effects of Ginseng: Multiple Constituents and Multiple Actions on Humans	10
Astragalus membranaceus as a Drug Candidate for Inflammatory Bowel Disease: The Preclinical Evidence	10
Acupuncture and Moxibustion for Inflammatory Bowel Disease: Regulatory Mechanisms Revealed by Microbiome and Metabolomic Analysis	10
Chinese Herbal Medicine, Alternative or Complementary, for Endometriosis-Associated Pain: A Meta-Analysis	10
Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway	10
ERRATUM: Cytokine Storm in Acute Viral Respiratory Injury: Role of Qing-Fei-Pai-Du Decoction in Inhibiting the Infiltration of Neutrophils and Macrophages through TAK1/IKK/NF-κB Pathway	10
Advancements in the Research of Astragalus membranaceus for the Treatment of Colorectal Cancer	10
Effects of Crocin on CCL2/CCR2 Inflammatory Pathway in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats	9
Research Advances in Lotus Leaf as Chinese Dietary Herbal Medicine	9
Atractylodes lancea Rhizoma Attenuates DSS-Induced Colitis by Regulating Intestinal Flora and Metabolites	9
Mechanisms of Danggui Buxue Tang on Hematopoiesis via Multiple Targets and Multiple Components: Metabonomics Combined with Database Mining Technology	9
Traditional Chinese Medicine for COVID-19: A Network Meta-Analysis and Systematic Review	9
Triterpenoid Compounds from Cyclocarya paliurus: A Review of Their Phytochemistry, Quality Control, Pharmacology, and Structure–Activity Relationship	9
Baicalein Preconditioning Cardioprotection Involves Pro-Oxidant Signaling and Activation of Pyruvate Dehydrogenase	9
Pachymic Acid Prevents Hemorrhagic Shock-Induced Cardiac Injury by Suppressing M1 Macrophage Polarization and NF-κB Signaling Pathway	9
Korean Red Ginseng Relieves Inflammation and Modulates Immune Response Induced by Pseudo-Type SARS-CoV-2	9
Amelioration of Lung Fibrosis by Total Flavonoids of Astragalus via Inflammatory Modulation and Epithelium Regeneration	9
The Effectiveness of Traditional Chinese Medicine in Treating Malignancies via Regulatory Cell Death Pathways and the Tumor Immune Microenvironment: A Review of Recent Advances	9
Research Progress of Chinese Medicine in the Treatment of Myocardial Ischemia–Reperfusion Injury	9
Research Progress in Ulcerative Colitis: The Role of Traditional Chinese Medicine on Gut Microbiota and Signaling Pathways	9
Tetrandrine Inhibits Cancer Stem Cell Characteristics and Epithelial to Mesenchymal Transition in Triple-Negative Breast Cancer via SOD1/ROS Signaling Pathway	9
Ginsenoside Rk1 Ameliorates ER Stress-Induced Apoptosis through Directly Activating IGF-1R in Mouse Pancreatic β-Cells and Diabetic Pancreas	8
Cucurbitacin B Inhibits the Malignancy of Esophageal Carcinoma through the KIF20A/JAK/STAT3 Signaling Pathway	8
Rutaecarpine Alleviates Early Brain Injury-Induced Inflammatory Response Following Subarachnoid Hemorrhage via SIRT6/NF-κB Pathway	8
Components from Curcuma longa (Turmeric) Against Hepatobiliary Diseases Based on Gut–Liver Axis: Pharmacotherapeutic Properties and Potential Clinical Applications	8
Anticancer Effects of Morusin in Prostate Cancer via Inhibition of Akt/mTOR Signaling Pathway	8
Polyphyllin VII Promotes Apoptosis in Breast Cancer by Inhibiting MAPK/ERK Signaling Pathway through Downregulation of SOS1	8
Wogonin Inhibits Colorectal Cancer Proliferation and Epithelial Mesenchymal Transformation by Suppressing Phosphorylation in the AKT Pathway	8
Ginseng as a Key Immune Response Modulator in Chinese Medicine: From Antipandemic History to COVID-19 Management	8

ERRATUM: Quercetin Inhibits Intrahepatic Cholangiocarcinoma by Inducing Ferroptosis and Inhibiting Invasion via the NF-κB Pathway	8
Mechanism of Acupuncture in Treating Obesity: Advances and Prospects	7
Curcumol Exerts Antitumor Effect via Inhibiting EGFR-Akt-Mcl-1 Signaling	7
Cornel Iridoid Glycoside and Its Effective Component Regulate ATPase Vps4A/JNK to Alleviate Autophagy Deficit with Autophagosome Accumulation	7
Efficacy and Safety of Chinese Medicine for COVID-19: A Systematic Review and Meta-Analysis	7
Triptolide Attenuates Renal Slit Diagram to Tight Junction Transition in Diabetic Kidney Disease by Regulating Nrf2–Ferroptosis Pathway	7
Curcumin Inhibits T Follicular Helper Cell Differentiation in Mice with Dextran Sulfate Sodium (DSS)-Induced Colitis	7
Ameliorative Effects of Malonyl Ginsenoside fromPanax ginsengon Glucose-Lipid Metabolism and Insulin Resistance via IRS1/PI3K/Akt and AMPK Signaling Pathways in Type 2 Diabetic Mice	7
Ameliorative Effect of Glycyrrhizic Acid on Diosbulbin B-Induced Liver Injury and Its Mechanism	7
Advances in Anti-Osteoporosis Polysaccharides Derived from Medicinal Herbs and Other Edible Substances	7
Therapeutic Effect and Mechanism of Acupuncture in Autoimmune Diseases	7
Ginsenoside Rh4 Ameliorates Cisplatin-Induced Intestinal Toxicity via PGC-1α-Mediated Mitochondrial Autophagy and Apoptosis Pathways	7
Machine Learning Approaches in Traditional Chinese Medicine: A Systematic Review	7
Protective Effect of Ginsenosides from Stems and Leaves of Panax ginseng against Scopolamine-Induced Memory Damage via Multiple Molecular Mechanisms	7
Biometrics Data Visualization of Ginsenosides in Anticancer Investigations	7
Research Progress of Chinese Medicine in Treating Chronic Liver Disease by Regulating Autophagy	7
Osthole Exerts Inhibitory Effects on Hypoxic Colon Cancer Cells via EIF2α Phosphorylation-mediated Apoptosis and Regulation of HIF-1α	7
Advances in Pharmacological Research on Icaritin: A Comprehensive Review	6
Zingiber officinale: A Systematic Review of Botany, Phytochemistry and Pharmacology of Gut Microbiota-Related Gastrointestinal Benefits	6
Atractylodin: An Alkyne Compound with Anticancer Potential	6
The Role ofGynostemma pentaphyllumin Regulating Hyperlipidemia	6
Isoliquiritigenin Suppresses Breast Tumor Development by Enhancing Host Antitumor Immunity	6
Acupuncture: A Review of the Safety and Adverse Events and the Strategy of Potential Risk Prevention	6
The Pharmacology and Toxicology of Ginkgolic Acids: Secondary Metabolites from Ginkgo biloba	6
Arteannuin B Enhances the Effectiveness of Cisplatin in Non-Small Cell Lung Cancer by Regulating Connexin 43 and MAPK Pathway	6
Therapeutic Effects ofAlisma orientaleand its Active Constituents on Cardiovascular Disease and Obesity	6
Anti-Inflammatory Effects of Lupeol as a Candidate for New Drug Development	6
Mechanistic Role ofScutellaria baicalensisGeorgi in Breast Cancer Therapy	6
Role of Traditional Chinese Medicine in Lung Cancer Management: A Review	6
Chinese Herbal Medicine for Irritable Bowel Syndrome: A Perspective of Local Immune Actions	6
A Review of Traditional Chinese Medicine for Triple Negative Breast Cancer and the Pharmacological Mechanisms	6
Research Progress of Chinese Medicine in the Regulation of Liver Fibrosis-Related Signaling Pathways	6
Salidroside Ameliorates Ischemia-Induced Neuronal Injury through AMPK Dependent and Independent Pathways to Maintain Mitochondrial Quality Control	5
Saponins From Platycodon grandiflorum Reduces Cisplatin-Induced Intestinal Toxicity in Mice through Endoplasmic Reticulum Stress-Activated Apoptosis	5
Veratramine Inhibits the Cell Cycle Progression, Migration, and Invasion via ATM/ATR Pathway in Androgen-Independent Prostate Cancer	5
20(S)-Protopanaxadiol fromPanax ginsengInduces Apoptosis and Autophagy in Gastric Cancer Cells by Inhibiting Src	5
Notoginsenoside R1, An Active Compound from Panax notoginseng, Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis via MAPK Signaling Pathway	5
Fucoxanthin Prevents Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Ferroptosis via Nrf2/STAT3 and Glutathione Pathways	5
Baicalin Ameliorates Lung Injury in Rats by Inhibiting NLRP3 Inflammasome Activation via NF-κB Signaling Pathway	5
Platycodin D Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis by Blocking the Activation of Mitogen-Activated Protein Kinases and the Production of Interleukin-8	5
Sinomenium acutum: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology and Clinical Application	5
Quercetin Inhibits Intrahepatic Cholangiocarcinoma by Inducing Ferroptosis and Inhibiting Invasion via the NF-κB Pathway	5
Bergenin Inhibits Tumor Growth and Overcomes Radioresistance by Targeting Aerobic Glycolysis	5
Capsaicin Reduces Cancer Stemness and Inhibits Metastasis by Downregulating SOX2 and EZH2 in Osteosarcoma	5
Standardized Extract ofCentella asiaticaPrevents Fear Memory Deficit in 3xTg-AD Mice	5
Ginsenosides are Promising Medicine for Tumor and Inflammation: A Review	5
Isoliquiritigenin Inhibits Oral Squamous Cell Carcinoma and Overcomes Chemoresistance by Destruction of Survivin	5
The Role of Traditional Chinese Medicine in the Management of Cervical Cancer	4
Ginsenoside Re Attenuates Cisplatin-Induced Intestinal Toxicity via Suppressing GSK-3β-Dependent Wnt/β-Catenin Signaling Pathway In Vivo and In Vitro	4
Traditional Uses, Phytochemistry, Pharmacology, Quality Control, Industrial Application, Pharmacokinetics and Network Pharmacology of Pogostemon cablin: A Comprehensive Review	4
Gambogic Acid Induces HO-1 Expression and Cell Apoptosis through p38 Signaling in Oral Squamous Cell Carcinoma	4
Therapeutic Potentials of Medicinal Leech in Chinese Medicine	4
Herbal Medicines for Constipation and Phytochemical Comparison of Active Components	4
Chinese Medicine in the Treatment of Ulcerative Colitis: The Mechanisms of Signaling Pathway Regulations	4
Target-Specific Drug Discovery of Natural Products against SARS-CoV-2 Life Cycle and Cytokine Storm in COVID-19	4
Multidirectional Intervention of Chinese Herbal Medicine in the Prevention and Treatment of Atherosclerosis: From Endothelial Protection to Immunomodulation	4
Integrative Analysis of the Gut Microbiota and Metabolome in Obese Mice with Electroacupuncture by 16S rRNA Gene Sequencing and HPLC–MS-based Metabolic Profiling	4
Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury	4
Andrographolide Attenuates Oxidized LDL-Induced Activation of the NLRP3 Inflammasome in Bone Marrow-Derived Macrophages and Mitigates HFCCD-Induced Atherosclerosis in Mice	4
In vitro and in vivo Experimental Investigation of Anti-Inflammatory Effects of Peucedanum japonicum Aqueous Extract by Suppressing the LPS-Induced NF-κB/MAPK JNK Pathways	4
Schisandrol A, the Major Active Constitute in Schisandra chinensis: A Review of Its Preparation, Biological Activities, and Pharmacokinetics Analysis	3
Ginseng-Containing Sijunzi Decoction Ameliorates Ulcerative Colitis by Orchestrating Gut Homeostasis in Microbial Modulation and Intestinal Barrier Integrity	3
Effects of Capsaicin on the Hypoglycemic Regulation of Metformin and Gut Microbiota Profiles in Type 2 Diabetic Rats	3
Gut Microbiota Regulation by Acupuncture and Moxibustion: A Systematic Review and Meta-Analysis	3
Ginsenoside Rb1 Relieves Cellular Senescence and Pulmonary Fibrosis by Promoting NRF2/QKI/SMAD7 Axis	3
Acupuncture and Acupoints for Low Back Pain: Systematic Review and Meta-Analysis	3
Nrf2-Dependent Protective Effect of Paeoniflorin on α-Naphthalene Isothiocyanate-Induced Hepatic Injury	3
Probiotic Fermentation of Herbal Medicine: Progress, Challenges, and Opportunities	3
Deer Velvet Antler Extracts Exert Anti-Inflammatory and Anti-Arthritic Effects on Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Distinct Mouse Arthritis	3
Curcumin-Pretreated Adipose-Derived Stem Cells Enhance the Neuroprotective Ability to Repair Rheumatoid Arthritis-Induced Damage in the Rat Brain	3
Astragaloside I from Astragalus Attenuates Diabetic Kidney Disease by Regulating HDAC3/Klotho/TGF-β1 Loop	3
Formononetin Alleviates Ischemic Acute Kidney Injury by Regulating Macrophage Polarization through KLF6/STAT3 Pathway	3
Metabolomics Analysis of Electroacupuncture Pretreatment Induced Neuroprotection on Mice with Ischemic Stroke	3
Regulating the Imbalance of Gut Microbiota by Smilax china L. Polyphenols to Alleviate Dextran Sulfate Sodium-induced Inflammatory Bowel Diseases	3
Baicalin Blocks Colon Cancer Cell Cycle and Inhibits Cell Proliferation through miR-139-3p Upregulation by Targeting CDK16	3
MicroRNAs, Key Regulators in Glioma Progression as Potential Therapeutic Targets for Chinese Medicine	3
Dietary Supplements for Pain Relief in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials	3
Chicoric Acid Presented NLRP3-Mediated Pyroptosis through Mitochondrial Damage by PDPK1 Ubiquitination in an Acute Lung Injury Model	3
Clinical Efficacy and Safety of Chinese Patent Medicine Combined with Oseltamivir for the Treatment of Adult Influenza: A Systematic Review and Meta-Analysis	3
Flavonoids Derived from Chinese Medicine: Potential Neuroprotective Agents	3

A Systematic Review on Polysaccharides from Dendrobium Genus: Recent Advances in the Preparation, Structural Characterization, Bioactive Molecular Mechanisms, and Applications	3
Dexmedetomidine Mitigates Myocardial Ischemia/Reperfusion-Induced Mitochondrial Apoptosis through Targeting lncRNA HCP5	3
Berberine Metabolites Stimulate GLP-1 Secretion by Alleviating Oxidative Stress and Mitochondrial Dysfunction	3
A Novel Paradigm Defines Functional Molecule Clusters for an Anti-Alzheimer’s Disease Recipe from Traditional Chinese Medicine	3