American Journal of Chinese Medicine

Article	Citations
Acupuncture Medical Therapy and its Underlying Mechanisms: A Systematic Review	53
Ginsenoside Rb1 Inhibits Cardiomyocyte Autophagy via PI3K/Akt/mTOR Signaling Pathway and Reduces Myocardial Ischemia/Reperfusion Injury	38
Intestinal Flora: A Pivotal Role in Investigation of Traditional Chinese Medicine	35
Tanshinone IIA: New Perspective on the Anti-Tumor Mechanism of A Traditional Natural Medicine	29
Colorectal Cancer, Gut Microbiota and Traditional Chinese Medicine: A Systematic Review	28
How Chinese Herbal Medicine Prevents Epidemics: From Ancient Pestilences to COVID-19 Pandemic	27
The Impact of Artificial Intelligence on Traditional Chinese Medicine	26
Ginsenoside Rh1 Improves Type 2 Diabetic Nephropathy through AMPK/PI3K/Akt-Mediated Inflammation and Apoptosis Signaling Pathway	26
Breviscapine: A Review on its Phytochemistry, Pharmacokinetics and Therapeutic Effects	25
Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway	25
Berberine and Ginsenoside Rb1 Ameliorate Depression-Like Behavior in Diabetic Rats	25
Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD+-CD38 Axis	24
Isoliquiritigenin Suppresses EMT-Induced Metastasis in Triple-Negative Breast Cancer through miR-200c/C-JUN/β-Catenin	24
Chinese Medicine in the Treatment of Ulcerative Colitis: The Mechanisms of Signaling Pathway Regulations	23
The Role of Acupuncture on the Gut–Brain–Microbiota Axis in Irritable Bowel Syndrome	22
Schisandra sphenanthera: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications	21
Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action	20
Atractylodes lancea Rhizoma Attenuates DSS-Induced Colitis by Regulating Intestinal Flora and Metabolites	20
Add-On Chinese Medicine for Coronavirus Disease 2019 (ACCORD): A Retrospective Cohort Study of Hospital Registries	20
Medicinal Inula Species: Phytochemistry, Biosynthesis, and Bioactivities	19
Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling	19
20(S)-Ginsenoside Rg3 Inhibits Lung Cancer Cell Proliferation by Targeting EGFR-Mediated Ras/Raf/MEK/ERK Pathway	19
Efficacy of Traditional Chinese Medicine Combined with Selective Serotonin Reuptake Inhibitors on the Treatment for Parkinson’s Disease with Depression: A Systematic Review and Meta-Analysis	18
Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway	18
Potential Role of Gut Microbiota in Traditional Chinese Medicine against COVID-19	18

A Review of Traditional Chinese Medicine on Treatment of Diabetic Nephropathy and the Involved Mechanisms	17
Research Advances in Lotus Leaf as Chinese Dietary Herbal Medicine	17
Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol	17
Ginsenoside Rd Inhibited Ferroptosis to Alleviate CCl4-Induced Acute Liver Injury in Mice via cGAS/STING Pathway	17
Quercetin Ameliorates Diabetic Kidney Injury by Inhibiting Ferroptosis via Activating Nrf2/HO-1 Signaling Pathway	16
Machine Learning Approaches in Traditional Chinese Medicine: A Systematic Review	16
Effect and Mechanism of Qingfei Paidu Decoction in the Management of Pulmonary Fibrosis and COVID-19	16
Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer	16
Gut Microbiota in Tumor Microenvironment: A Critical Regulator in Cancer Initiation and Development as Potential Targets for Chinese Medicine	16
Electroacupuncture Attenuates Chronic Inflammatory Pain and Depression Comorbidity through Transient Receptor Potential V1 in the Brain	16
Mori ramulus and its Major Component Morusin Inhibit Herpes Simplex Virus Type 1 Replication and the Virus-Induced Reactive Oxygen Species	16
Network Pharmacology Analysis to Explore the Pharmacological Mechanism of Effective Chinese Medicines in Treating Metastatic Colorectal Cancer using Meta-Analysis Approach	15
Ginsenoside Rg3 Suppresses Epithelial-Mesenchymal Transition via Downregulating Notch-Hes1 Signaling in Colon Cancer Cells	15
Battlefield Acupuncture for Adult Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials	15
Baicalin Protects Against Acute Pancreatitis Involving JNK Signaling Pathway via Regulating miR-15a	15
Ginseng-Containing Sijunzi Decoction Ameliorates Ulcerative Colitis by Orchestrating Gut Homeostasis in Microbial Modulation and Intestinal Barrier Integrity	15
Oligosaccharides from Traditional Chinese Herbal Medicines: A Review of Chemical Diversity and Biological Activities	15
Biochanin A from Chinese Medicine: An Isoflavone with Diverse Pharmacological Properties	15
Traditional Chinese Medicine Decoctions Significantly Reduce the Mortality in Severe and Critically Ill Patients with COVID-19: A Retrospective Cohort Study	15
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling	15
Polyphenols from Chinese Herbal Medicine: Molecular Mechanisms and Therapeutic Targets in Pulmonary Fibrosis	15
Epigallocatechin Gallate Reduces Homocysteine-Caused Oxidative Damages through Modulation SIRT1/AMPK Pathway in Endothelial Cells	15
Dragon’s Blood from Dracaena Worldwide: Species, Traditional Uses, Phytochemistry and Pharmacology	14
The Traditional Usages, Chemical Components and Pharmacological Activities of Wolfiporia cocos: A Review	14
Protective Effect of Dihydrokaempferol on Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway	14
Exploring the Potential Pharmacological Mechanism of Hesperidin and Glucosyl Hesperidin against COVID-19 Based on Bioinformatics Analyses and Antiviral Assays	14
Efficacy of Acupuncture for Insomnia: A Systematic Review and Meta-Analysis	13
Deer Velvet Antler Extracts Exert Anti-Inflammatory and Anti-Arthritic Effects on Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Distinct Mouse Arthritis	13
Neuraminidase 1 and its Inhibitors from Chinese Herbal Medicines: An Emerging Role for Cardiovascular Diseases	12
Identifying Dose Components of Manual Acupuncture to Determine the Dose–Response Relationship of Acupuncture Treatment: A Systematic Review	12
Effects of Berberine on Gut Microbiota in Patients with Mild Metabolic Disorders Induced by Olanzapine	12
Research Progress of Chinese Medicine in the Treatment of Myocardial Ischemia–Reperfusion Injury	12
Ligustrazine Suppresses Platelet-Derived Growth Factor-BB-Induced Pulmonary Artery Smooth Muscle Cell Proliferation and Inflammation by Regulating the PI3K/AKT Signaling Pathway	12
Bibliometric Analysis of Integrative Medicine Studies from 2000 to 2019	12
Notoginsenoside R1, An Active Compound from Panax notoginseng, Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis via MAPK Signaling Pathway	12
Serum Starvation Sensitizes Anticancer Effect of Anemarrhena asphodeloides via p38/JNK-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells	12
Neohesperidin Induces Cell Cycle Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells	12
Research Advances in Protective Effects of Ursolic Acid and Oleanolic Acid Against Gastrointestinal Diseases	12
A Review of Pharmacological and Toxicological Effects of Sophora tonkinensis with Bioinformatics Prediction	12
Therapeutic Effects of Shikonin on Skin Diseases: A Review	12
Systems Pharmacology-Based Strategy to Explore the Pharmacological Mechanisms of Citrus Peel (Chenpi) for Treating Complicated Diseases	11
Inhibitory Effect of Gallotannin on Lung Metastasis of Metastatic Colorectal Cancer Cells by Inducing Apoptosis, Cell Cycle Arrest and Autophagy	11
Angiogenic Actions of Paeoniflorin on Endothelial Progenitor Cells and in Ischemic Stroke Rat Model	11
Mistletoe Extract Targets the STAT3-FOXM1 Pathway to Induce Apoptosis and Inhibits Metastasis in Breast Cancer Cells	11
The Role of Ophiopogonin D in Atherosclerosis: Impact on Lipid Metabolism and Gut Microbiota	11
Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway	10
Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway	10
Panax notoginseng Saponins Modulate the Inflammatory Response and Improve IBD-Like Symptoms via TLR/NF-κB and MAPK Signaling Pathways	10
Effectiveness of Integrative Chinese–Western Medicine for Chronic Kidney Disease and Diabetes: A Retrospective Cohort Study	10
CD39/CD73/A2a Adenosine Metabolic Pathway: Targets for Moxibustion in Treating DSS-Induced Ulcerative Colitis	10

The Pharmacological Rationales and Molecular Mechanisms ofGanoderma lucidumPolysaccharides for the Therapeutic Applications of Multiple Diseases	10
Falcarindiol Stimulates Apoptotic and Autophagic Cell Death to Attenuate Cell Proliferation, Cell Division, and Metastasis through the PI3K/AKT/mTOR/p70S6K Pathway in Human Oral Squamous Cell Carcinom	10
The Toxicity and Attenuation Methods of Toxic Chinese Materia Medica for its Reasonable Application: A Review	10
Efficacy and Safety of Chinese Herbal Medicine on Treatment of Breast Cancer: A Meta-analysis of Randomized Controlled Trials	10
18β-Glycyrrhetinic Acid Inhibits TGF-β-Induced Epithelial-to-Mesenchymal Transition and Metastasis of Hepatocellular Carcinoma by Targeting STAT3	9
Multiple Mechanistic Models Reveal the Neuroprotective Effects of Diterpene Ginkgolides against Astrocyte-Mediated Demyelination via the PAF-PAFR Pathway	9
Effect of Sutellarin on Neurogenesis in Neonatal Hypoxia–Ischemia Rat Model: Potential Mechanisms of Action	9
Gut Microbiota and Urine Metabonomics Alterations in Constitution after Chinese Medicine and Lifestyle Intervention	9
Role of Purinergic Signaling in Acupuncture Therapeutics	8
Umbelliferone Inhibits Migration, Invasion and Inflammation of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Relieves Adjuvant-Induced Arthritis in Rats by Blockade of Wnt/β-Catenin Signaling	8
Angelica dahurica and Rheum officinale Facilitated Diabetic Wound Healing by Elevating Vascular Endothelial Growth Factor	8
Curcumin Inhibits T Follicular Helper Cell Differentiation in Mice with Dextran Sulfate Sodium (DSS)-Induced Colitis	8
Berberine Attenuates Hyperuricemia by Regulating Urate Transporters and Gut Microbiota	8
A Systemic Review for Ethnopharmacological Studies onIsatis indigoticaFortune: Bioactive Compounds and their Therapeutic Insights	8
Anti-Inflammatory and Anti-Oxidant Effects of Korean Ginseng Berry Extract in LPS-Activated RAW264.7 Macrophages	8
Berberine on the Prevention and Management of Cardiometabolic Disease: Clinical Applications and Mechanisms of Action	8
Sinomenium acutum: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology and Clinical Application	8
Therapeutic Effect and Mechanism of Acupuncture in Autoimmune Diseases	8
Fermentation of Sprouted Ginseng (Panax ginseng) Increases Flavonoid and Phenolic Contents to Attenuate Alcoholic Hangover and Acute Liver Injury in Mice	8
Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism	8
Herbal Medicines for Constipation and Phytochemical Comparison of Active Components	8
Protective Effects and Therapeutics of Ginsenosides for Improving Endothelial Dysfunction: From Therapeutic Potentials, Pharmaceutical Developments to Clinical Trials	8
Curcumin-Pretreated Adipose-Derived Stem Cells Enhance the Neuroprotective Ability to Repair Rheumatoid Arthritis-Induced Damage in the Rat Brain	8
Vaccinium bracteatum Improves Spatial Learning and Memory by Regulating N-methyl-D-aspartate Receptors and Tau Phosphorylation in Chronic Restraint Stress-Induced Memory Impaired Mice	8
Ginsenoside Rh2 Regulates the CFAP20DC-AS1/MicroRNA-3614-3p/BBX and TNFAIP3 Axis to Induce Apoptosis in Breast Cancer Cells	7
Puerarin Inhibits the PERK-eIF2α-ATF4-CHOP Pathway through Inactivating JAK2/STAT3 Signal in Pancreatic beta-Cells	7
Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury	7
Ziyuglycoside I Upregulates RUNX2 through ERK1/2 in Promoting Osteoblast Differentiation and Bone Mineralization	7
Perioperative Acupuncture Optimizes Surgical Outcomes: Theory, Clinical Practice and Future Perspectives	7
Hydroxysafflor Yellow A Alleviates Ischemic Stroke in Rats via HIF-1α, BNIP3, and Notch1-Mediated Inhibition of Autophagy	7
Traditional Uses, Phytochemistry, Pharmacology, Quality Control, Industrial Application, Pharmacokinetics and Network Pharmacology of Pogostemon cablin: A Comprehensive Review	7
Tangeretin Synergizes with 5-Fluorouracil to Induce Autophagy through MicroRNA-21 in Colorectal Cancer Cells	7
Using Metabolomics in Diabetes Management with Traditional Chinese Medicine: A Review	7
Astragalus Total Saponins Ameliorate Peritoneal Fibrosis by Promoting Mitochondrial Synthesis and Inhibiting Apoptosis	7
Protective Effect of 20(R)-Ginsenoside Rg3 Against Cisplatin-Induced Renal Toxicity via PI3K/AKT and NF-κB Signaling Pathways Based on the Premise of Ensuring Anticancer Effect	7
Therapeutic Effects ofAlisma orientaleand its Active Constituents on Cardiovascular Disease and Obesity	7
Integrative Analysis of the Gut Microbiota and Metabolome in Obese Mice with Electroacupuncture by 16S rRNA Gene Sequencing and HPLC–MS-based Metabolic Profiling	6
Osthole Exerts Inhibitory Effects on Hypoxic Colon Cancer Cells via EIF2α Phosphorylation-mediated Apoptosis and Regulation of HIF-1α	6
The Impact of Gut Microbiome on the Pharmacokinetics of Ginsenosides Rd and Rg3 in Mice after Oral Administration of Red Ginseng	6
The Phytochemistry of Ganoderma Species and their Medicinal Potentials	6
Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges	6
Zingiber officinale: A Systematic Review of Botany, Phytochemistry and Pharmacology of Gut Microbiota-Related Gastrointestinal Benefits	6
Effects of Stimulating Local and Distal Acupoints on Diabetic Gastroparesis: A New Insight in Revealing Acupuncture Therapeutics	6
Protective Effect of Ginsenosides from Stems and Leaves of Panax ginseng against Scopolamine-Induced Memory Damage via Multiple Molecular Mechanisms	6
Ameliorative Effects of Malonyl Ginsenoside fromPanax ginsengon Glucose-Lipid Metabolism and Insulin Resistance via IRS1/PI3K/Akt and AMPK Signaling Pathways in Type 2 Diabetic Mice	6
Proapoptotic Effect of Icariin on Human Ovarian Cancer Cells via the NF-κB/PI3K-AKT Signaling Pathway: A Network Pharmacology-Directed Experimental Investigation	6
Nanotechnology-Based Drug Delivery System for Anticancer Active Ingredients from Traditional Chinese Medicines: A Review	6
Gut Flora Mediates the Rapid Tolerance of Electroacupuncture on Ischemic Stroke by Activating Melatonin Receptor through Regulating Indole-3-Propionic Acid	6
Arteannuin B Enhances the Effectiveness of Cisplatin in Non-Small Cell Lung Cancer by Regulating Connexin 43 and MAPK Pathway	6
MicroRNAs, Key Regulators in Glioma Progression as Potential Therapeutic Targets for Chinese Medicine	6
Efficacy and Safety of Chinese Medicine for COVID-19: A Systematic Review and Meta-Analysis	6
Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis	6
The Gut Microbial Co-Abundance Gene Groups (CAGs) Differentially Respond to the Flavor (Yao-Wei) of Chinese Materia Medica	6
Helianthus Annuus L. Alleviates High-Fat Diet Induced Atherosclerosis by Regulating Intestinal Microbiota, Inhibiting Inflammation and Restraining Oxidative Stress	6
Neuroplasticity: A Key Player in the Antidepressant Action of Chinese Herbal Medicine	6
Acupuncture and Acupoints for Low Back Pain: Systematic Review and Meta-Analysis	6
Qigong and Tai Chi on Human Health: An Overview of Systematic Reviews	5
Amygdalin Induced Mitochondria-Mediated Apoptosis of Lung Cancer Cells via Regulating NFκB-1/NFκB Signaling Cascadein Vitroandin Vivo	5
Dexmedetomidine Mitigates Myocardial Ischemia/Reperfusion-Induced Mitochondrial Apoptosis through Targeting lncRNA HCP5	5
The Leaves of Cyclocarya paliurus: A Functional Tea with Preventive and Therapeutic Potential of Type 2 Diabetes	5
Matricaria chamomilla (Chamomile) Ameliorates Muscle Atrophy in Mice by Targeting Protein Catalytic Pathways, Myogenesis, and Mitochondrial Dysfunction	5
Platycodin D Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis by Blocking the Activation of Mitogen-Activated Protein Kinases and the Production of Interleukin-8	5
Traditional Chinese Medicine for COVID-19: A Network Meta-Analysis and Systematic Review	5
Chinese Medicine for Coronavirus Disease 2019 (COVID-19): A GRADE-Assessed Systematic Review and Meta-Analysis	5
Analysis of Gut Microbiota Composition in Lung Adenocarcinoma Patients with TCM Qi-Yin Deficiency	5
Efficacy and Safety of Glycyrrhizic Acid in Treatment of Autoimmune Hepatitis	5
Nrf2-Dependent Protective Effect of Paeoniflorin on α-Naphthalene Isothiocyanate-Induced Hepatic Injury	5
Ginsenoside Rg5: A Review of Anticancer and Neuroprotection with Network Pharmacology Approach	5
Advances in Anti-Osteoporosis Polysaccharides Derived from Medicinal Herbs and Other Edible Substances	4
Solasonine Inhibits Cancer Stemness and Metastasis by Modulating Glucose Metabolism via Wnt/β-Catenin/Snail Pathway in Osteosarcoma	4
Pharmacological Effects of Ginseng: Multiple Constituents and Multiple Actions on Humans	4
A Scoping Review of Cross-Sectional Studies on Traditional Chinese Medicine	4
Neuroprotective Effects ofAlpinia oxyphyllaMiq against Mitochondria-Related Apoptosis by the Interactions between Upregulated p38 MAPK Signaling and Downregulated JNK Signaling in the Subacute	4
11-O-Galloyl Bergenin from Corylopsis coreanas Leaves Induces Autophagy and Apoptosis in Human Osteosarcoma	4
Regulating the Imbalance of Gut Microbiota by Smilax china L. Polyphenols to Alleviate Dextran Sulfate Sodium-induced Inflammatory Bowel Diseases	4
Genistein Triggers Translocation of Estrogen Receptor-Alpha in Mitochondria to Induce Expressions of ATP Synthesis-Associated Genes and Improves Energy Production and Osteoblast Maturation	4
Effects of Crocin on CCL2/CCR2 Inflammatory Pathway in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats	4
Tetrandrine Inhibits Cancer Stem Cell Characteristics and Epithelial to Mesenchymal Transition in Triple-Negative Breast Cancer via SOD1/ROS Signaling Pathway	4
Cardioprotective Effects of Tetrahydropalmatine on Acute Myocardial Infarction in Rats	4
Efficacy and Safety of Acupuncture Vs. Hormone Therapy for Menopausal Syndrome: A Systematic Review and Meta-Analysis	4

Traditional Chinese Medicine for the Common Cold: Evidence and Potential Mechanisms	4
Paeoniflorin Coordinates Macrophage Polarization and Mitigates Liver Inflammation and Fibrogenesis by Targeting the NF-κB/HIF-1α Pathway in CCl4-Induced Liver Fibrosis	4
Psidium guajava Flavonoids Prevent NLRP3 Inflammasome Activation and Alleviate the Pancreatic Fibrosis in a Chronic Pancreatitis Mouse Model	4
Application of Traditional Chinese Medicine and Systems Pharmacology in Drug Prevention and Treatment against COVID-19	4
A Systematic Review on Polysaccharides from Dendrobium Genus: Recent Advances in the Preparation, Structural Characterization, Bioactive Molecular Mechanisms, and Applications	4
Target-Specific Drug Discovery of Natural Products against SARS-CoV-2 Life Cycle and Cytokine Storm in COVID-19	4
Mechanistic Role ofScutellaria baicalensisGeorgi in Breast Cancer Therapy	4
14-Deoxy-11,12-Didehydroandrographolide Ameliorates Glucose Intolerance Enhancing the LKB1/AMPKα/TBC1D1/GLUT4 Signaling Pathway and Inducing GLUT4 Expression in Myotubes and Skeletal Muscle of Obese M	4
Advances in the Application of Traditional Chinese Medicine Using Artificial Intelligence: A Review	4
Research Progress of Traditional Chinese Medicine Monomers in Reversing Multidrug Resistance of Breast Cancer	4
Efficacy and Safety of Chinese Herbal Medicine for Endometriosis Associated Pain	4
Standardization of Panax ginseng: Current Status of Global Trade, Demands, and Development	4
6,7,4′-Trihydroxyflavanone Prevents Methamphetamine-Induced T Cell Deactivation by Protecting the Activated T Cells from Apoptosis	4
Capsaicin Reduces Cancer Stemness and Inhibits Metastasis by Downregulating SOX2 and EZH2 in Osteosarcoma	4
Effects of Capsaicin on the Hypoglycemic Regulation of Metformin and Gut Microbiota Profiles in Type 2 Diabetic Rats	4