Applied Microbiology and Biotechnology

Article	Citations
Detection technologies and recent developments in the diagnosis of COVID-19 infection	217
Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics	156
The potential of Akkermansia muciniphila in inflammatory bowel disease	106
Production of bioactive plant secondary metabolites through in vitro technologies—status and outlook	96
A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress–induced depressive-like behavior in mice by regulating gut microbiota and metabolites	91
Bacillus as a source of phytohormones for use in agriculture	79
Progress in bioleaching: fundamentals and mechanisms of microbial metal sulfide oxidation – part A	71
Progress in bioleaching: part B, applications of microbial processes by the minerals industries	70
Biosynthesis and regulation of anthocyanin pathway genes	69
Biofilm formation and inhibition mediated by bacterial quorum sensing	67
Synthesis, biomedical applications, and toxicity of CuO nanoparticles	66
Biogenesis of silver nanoparticles to treat cancer, diabetes, and microbial infections: a mechanistic overview	63
Current status on the biodegradability of acrylic polymers: microorganisms, enzymes and metabolic pathways involved	61
Echinocandins: structural diversity, biosynthesis, and development of antimycotics	58
Engineering of the unfolded protein response pathway in Pichia pastoris: enhancing production of secreted recombinant proteins	58
Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story	58
Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections	58
Edible mushroom industry in China: current state and perspectives	57
Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae	56
Campylobacter sp.: Pathogenicity factors and prevention methods—new molecular targets for innovative antivirulence drugs?	55
Anaerobic biodegradation of phenol in wastewater treatment: achievements and limits	53
Responses of soil bacterial and fungal communities to the long-term monoculture of grapevine	51
Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer	51
Thermostability engineering of industrial enzymes through structure modification	48
The “beauty in the beast”—the multiple uses of Priestia megaterium in biotechnology	48

One-pot platform for rapid detecting virus utilizing recombinase polymerase amplification and CRISPR/Cas12a	46
Hairy root culture technology: applications, constraints and prospect	46
Characterization and function of membrane vesicles in Gram-positive bacteria	46
Streptomycetes as platform for biotechnological production processes of drugs	45
L-asparaginase production review: bioprocess design and biochemical characteristics	45
Fungal secondary metabolites in food and pharmaceuticals in the era of multi-omics	45
Living with sulfonamides: a diverse range of mechanisms observed in bacteria	45
The interaction of Akkermansia muciniphila with host-derived substances, bacteria and diets	45
Gut microbiome analysis as a predictive marker for the gastric cancer patients	45
Biological activity of oxadiazole and thiadiazole derivatives	45
Ligilactobacillus salivarius functionalities, applications, and manufacturing challenges	44
Novel mycosynthesis of Co3O4, CuO, Fe3O4, NiO, and ZnO nanoparticles by the endophytic Aspergillus terreus and evaluation of their antioxidant and antimicrobial activities	44
The periodic table of fermented foods: limitations and opportunities	43
Antifungal mechanism of 1-nonanol against Aspergillus flavus growth revealed by metabolomic analyses	42
Modeling and optimizing callus growth and development in Cannabis sativa using random forest and support vector machine in combination with a genetic algorithm	42
New insights in pectinase production development and industrial applications	42
Biodegradation of fipronil: current state of mechanisms of biodegradation and future perspectives	42
Perspective on the biotechnological production of bacterial siderophores and their use	40
Possible mechanisms for the equilibrium of ACC and role of ACC deaminase-producing bacteria	39
Progress of cationic gene delivery reagents for non-viral vector	39
Adaptive laboratory evolution of Yarrowia lipolytica improves ferulic acid tolerance	39
Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain–based vaccine candidate, RBD219-N1C1	38
An overview and future prospects of recombinant protein production in Bacillus subtilis	38
Impact of novel microbial secondary metabolites on the pharma industry	38
Enterobacteriaceae in food safety with an emphasis on raw milk and meat	37
Natural bacterial isolates as an inexhaustible source of new bacteriocins	37
Gut microbiota profiles and characterization of cultivable fungal isolates in IBS patients	37
Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb	36
Drug repurposing strategies in the development of potential antifungal agents	36
Pecularities and applications of aryl-alcohol oxidases from fungi	36
Synthesis and production of steviol glycosides: recent research trends and perspectives	36
Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses	36
D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity	36
Machine learning: its challenges and opportunities in plant system biology	35
Antibacterial and safety tests of a flexible cold atmospheric plasma device for the stimulation of wound healing	34
Psychrophilic enzymes: structural adaptation, pharmaceutical and industrial applications	34
Exploiting endophytic microbes as micro-factories for plant secondary metabolite production	34
The effect of bile acids on the growth and global gene expression profiles in Akkermansia muciniphila	34
Bacillus subtilis High Cell Density Fermentation Using a Sporulation-Deficient Strain for the Production of Surfactin	34
Sporulation in solventogenic and acetogenic clostridia	33
Towards sustainable agriculture: rhizosphere microbiome engineering	33
Milk fermented by Lactobacillus casei CRL431 administered as an immune adjuvant in models of breast cancer and metastasis under chemotherapy	33
Recent advancements for microorganisms and their natural compounds useful in agriculture	32
The newly synthesized thiazole derivatives as potential antifungal compounds against Candida albicans	32
Antifungal activity of different Xenorhabdus and Photorhabdus species against various fungal phytopathogens and identification of the antifungal compounds from X. szentirmaii	32
Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota	32
In-depth understanding of molecular mechanisms of aldehyde toxicity to engineer robust Saccharomyces cerevisiae	32
Current view on novel vaccine technologies to combat human infectious diseases	32
Development of a p72 trimer–based colloidal gold strip for detection of antibodies against African swine fever virus	32
Development of thermostable sucrose phosphorylase by semi-rational design for efficient biosynthesis of alpha-D-glucosylglycerol	31

Thermostable lipases and their dynamics of improved enzymatic properties	31
Antifungal activity of silver nanoparticles synthesized by iturin against Candida albicans in vitro and in vivo	31
Genome-scale metabolic network models: from first-generation to next-generation	31
Cephalosporins as key lead generation beta-lactam antibiotics	31
Biotransformation ability of endophytic fungi: from species evolution to industrial applications	31
Thiamine: a key nutrient for yeasts during wine alcoholic fermentation	31
Bacillibactin class of siderophore antibiotics from a marine symbiotic Bacillus as promising antibacterial agents	31
Modifications of diketopiperazines assembled by cyclodipeptide synthases with cytochrome P450 enzymes	31
Natural products from Photorhabdus and Xenorhabdus: mechanisms and impacts	30
Recent advances in microbial production of L-malic acid	29
Harmful effects of metal(loid) oxide nanoparticles	29
Temporal dynamics of gut microbiota in caged laying hens: a field observation from hatching to end of lay	29
Pediococcus pentosaceus ZJUAF-4 relieves oxidative stress and restores the gut microbiota in diquat-induced intestinal injury	29
Effect of quorum-sensing molecule 2-phenylethanol and ARO genes on Saccharomyces cerevisiae biofilm	29
Mucoromycota fungi as powerful cell factories for modern biorefinery	28
Pseudomonas putida and its close relatives: mixing and mastering the perfect tune for plants	28
Stochastic processes shape the bacterial community assembly in shrimp cultural pond sediments	28
Purification, characterization, and mode of action of Paracin 54, a novel bacteriocin against Staphylococci	28
Development and application of a colloidal-gold dual immunochromatography strip for detecting African swine fever virus antibodies	28
Potential role of IFN-α in COVID-19 patients and its underlying treatment options	28
Difficidin class of polyketide antibiotics from marine macroalga-associated Bacillus as promising antibacterial agents	27
Genetic tools for the redirection of the central carbon flow towards the production of lactate in the human gut bacterium Phocaeicola (Bacteroides) vulgatus	27
Eco-friendly polyurethane acrylate (PUA)/natural filler-based composite as an antifouling product for marine coating	27
High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cells	27
Microbial endophytes: application towards sustainable agriculture and food security	27
Phage therapeutics: from promises to practices and prospectives	27
Toxin-antitoxin systems and their medical applications: current status and future perspective	27
OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potential	26
Relevance of Candidatus Nitrotoga for nitrite oxidation in technical nitrogen removal systems	26
Challenges and perspectives of the β-galactosidase enzyme	26
Seed coating as a delivery system for the endophyte Trichoderma koningiopsis Th003 in rice (Oryza sativa)	26
Serendipita indica alleviates drought stress responses in walnut (Juglans regia L.) seedlings by stimulating osmotic adjustment and antioxidant defense system	26
Progress in fed-batch culture for recombinant protein production in CHO cells	26
Biotechnological strategies for the sustainable production of diosgenin from Dioscorea spp.	26
Evolutionary and reverse engineering to increase Saccharomyces cerevisiae tolerance to acetic acid, acidic pH, and high temperature	26
Spatial and seasonal variations of sediment bacterial communities in a river-bay system in South China	26
Metabolic engineering of Saccharomyces cerevisiae for enhanced production of caffeic acid	26
Current insights into the microbial degradation for butachlor: strains, metabolic pathways, and molecular mechanisms	25
Interactive effects of light quality and culturing temperature on algal cell size, biomass doubling time, protein content, and carbohydrate content	25
Metagenomic insights into the effect of sulfate on enhanced biological phosphorus removal	25
Development overview of Raman-activated cell sorting devoted to bacterial detection at single-cell level	25
Campylobacter jejuni: targeting host cells, adhesion, invasion, and survival	25
Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine	25
Biotechnological utilization: the role of Zea mays rhizospheric bacteria in ecosystem sustainability	25
Phytotoxic compounds from endophytic fungi	25
The antifungal mechanisms of plant volatile compound 1-octanol against Aspergillus flavus growth	25
The functions of glutathione peroxidase in ROS homeostasis and fruiting body development in Hypsizygus marmoreus	25
Current postbiotics in the cosmetic market—an update and development opportunities	25
Molecular strategies to increase keratinase production in heterologous expression systems for industrial applications	25
Shifts of microbiota during cheese production: impact on production and quality	25
An overview of Trichoderma reesei co-cultures for the production of lignocellulolytic enzymes	25
Indigoidine biosynthesis triggered by the heavy metal-responsive transcription regulator: a visual whole-cell biosensor	25
Microbial diversity in jiuqu and its fermentation features: saccharification, alcohol fermentation and flavors generation	25
Colorimetric detection of Pseudomonas aeruginosa by aptamer-functionalized gold nanoparticles	25
Synergistic antimicrobial activity of N-methyl substituted pyrrolidinium–based ionic liquids and melittin against Gram-positive and Gram-negative bacteria	24
The impact of bZIP Atf1ortholog global regulators in fungi	24
Modeling the dynamic kinetics of microbial disinfection with dissipating chemical agents—a theoretical investigation	24
6-Methylcoumarin attenuates quorum sensing and biofilm formation in Pseudomonas aeruginosa PAO1 and its applications on solid surface coatings with polyurethane	24
Inducing red pigment and inhibiting citrinin production by adding lanthanum(III) ion in Monascus purpureus fermentation	24
Recent advances of Cas12a applications in bacteria	24
The microbiome of bat guano: for what is this knowledge important?	24
The fungal community outperforms the bacterial community in predicting plant health status	24
Biodegradation of lignin monomers and bioconversion of ferulic acid to vanillic acid by Paraburkholderia aromaticivorans AR20-38 isolated from Alpine forest soil	24
The biological approaches of altering the growth and biochemical properties of medicinal plants under salinity stress	24
Whole-plant corn silage improves rumen fermentation and growth performance of beef cattle by altering rumen microbiota	24
Ethyl carbamate in Chinese liquor (Baijiu): presence, analysis, formation, and control	24
Biodegradation of diisononyl phthalate by a consortium of saline soil bacteria: optimisation and kinetic characterisation	24
Halomonas spp., as chassis for low-cost production of chemicals	24
Comparison of the fermentation and bacterial community in the colon of Hu sheep fed a low-grain, non-pelleted, or pelleted high-grain diet	24
o-Vanillin, a promising antifungal agent, inhibits Aspergillus flavus by disrupting the integrity of cell walls and cell membranes	24
The ecology of wine fermentation: a model for the study of complex microbial ecosystems	24
Enzymatic synthesis of fluorinated compounds	24
Exploring the molecular content of CHO exosomes during bioprocessing	24
Research progress and the biotechnological applications of multienzyme complex	24
Regulatory effects of transition metals supplementation/deficiency on the gut microbiota	24
Pseudomonas aeruginosa virulence attenuation by inhibiting siderophore functions	23
Hexanal induces early apoptosis of Aspergillus flavus conidia by disrupting mitochondrial function and expression of key genes	23
Antimicrobial peptides used as growth promoters in livestock production	23
Fermentative production of propionic acid: prospects and limitations of microorganisms and substrates	23
A Baeyer-Villiger monooxygenase from Cupriavidus basilensis catalyzes asymmetric synthesis of (R)-lansoprazole and other pharmaco-sulfoxides	23

Glutathione production by Saccharomyces cerevisiae: current state and perspectives	23
Helicobacter pylori infection worsens impaired glucose regulation in high-fat diet mice in association with an altered gut microbiome and metabolome	23
Modulation of the immune response and metabolism in germ-free rats colonized by the probiotic Lactobacillus salivarius LI01	23
Preparation and applications of keratin biomaterials from natural keratin wastes	23
Diet-induced microbiome shifts of sympatric overwintering birds	23
Fungal mutualisms and pathosystems: life and death in the ambrosia beetle mycangia	23
Combined isoflavones biotransformation increases the bioactive and antioxidant capacity of soymilk	23
Comparative roles of three adhesin genes (adh1–3) in insect-pathogenic lifecycle of Beauveria bassiana	23
Nationality and body location alter human skin microbiome	23
Innovative next-generation therapies in combating multi-drug-resistant and multi-virulent Escherichia coli isolates: insights from in vitro, in vivo, and molecular docking studies	22
Research progress on the degradation mechanism and modification of keratinase	22
Simultaneous elucidation of antibiotic mechanism of action and potency with high-throughput Fourier-transform infrared (FTIR) spectroscopy and machine learning	22
Sequencing of SARS-CoV-2 genome using different nanopore chemistries	22
Gut microbiota: a new avenue to reveal pathological mechanisms of constipation	22
Strategies for enhancing terpenoids accumulation in microalgae	22
On the nutritional and therapeutic effects of ketone body d-β-hydroxybutyrate	22
Marine dissolved organic matter: a vast and unexplored molecular space	22
Recombinant Treponema pallidum protein Tp0768 promotes proinflammatory cytokine secretion of macrophages through ER stress and ROS/NF-κB pathway	22
Recent advances in the potential applications of luminescence-based, SPR-based, and carbon-based biosensors	22
Gluten-degrading bacteria: availability and applications	22
Overview of a bioremediation tool: organophosphorus hydrolase and its significant application in the food, environmental, and therapy fields	22
Fungal quinones: diversity, producers, and applications of quinones from Aspergillus, Penicillium, Talaromyces, Fusarium, and Arthrinium	22
Heat stress in macrofungi: effects and response mechanisms	22
Rhodotorula sp.–based biorefinery: a source of valuable biomolecules	22
Improving the functionality of surface-engineered yeast cells by altering the cell wall morphology of the host strain	22
Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods	22
Bioprospecting of microbial enzymes: current trends in industry and healthcare	22
Integrating transcriptomic and metabolomic analysis of the oleaginous yeast Rhodosporidium toruloides IFO0880 during growth under different carbon sources	21
Mechanisms underlying the inhibitory effects of linalool on Aspergillus flavus spore germination	21
Heat preadaptation improved the ability of Zygosaccharomyces rouxii to salt stress: a combined physiological and transcriptomic analysis	21
Endophytes: the novel sources for plant terpenoid biosynthesis	21
Synergistic biodegradation of poly(ethylene terephthalate) using Microbacterium oleivorans and Thermobifida fusca cutinase	21
Recent advances and new insights in biosynthesis of dendrobine and sesquiterpenes	21
Advances in the biosynthesis and metabolic engineering of rare ginsenosides	21
Targeting effect of berberine on type I fimbriae of Salmonella Typhimurium and its effective inhibition of biofilm	21
Probiotics ameliorate chronic low-grade inflammation and fat accumulation with gut microbiota composition change in diet-induced obese mice models	21
Geraniol eradicates Candida glabrata biofilm by targeting multiple cellular pathways	21
Photoinactivation of mycobacteria to combat infection diseases: current state and perspectives	21
Characterisation of cytotoxicity and immunomodulatory effects of glycolipid biosurfactants on human keratinocytes	21
Biotechnology of camptothecin production in Nothapodytes nimmoniana, Ophiorrhiza sp. and Camptotheca acuminata	21
Advances in monitoring and control of refolding kinetics combining PAT and modeling	21
Crystal transformation and self-assembly theory of microbially induced calcium carbonate precipitation	21
Panorama of intron dynamics and gene rearrangements in the phylum Basidiomycota as revealed by the complete mitochondrial genome of Turbinellus floccosus	21
Underground metabolism facilitates the evolution of novel pathways for vitamin B6 biosynthesis	20
Engineered nanomaterials in plant diseases: can we combat phytopathogens?	20
Microbial debromination of hexabromocyclododecanes	20
Antibacterial mechanism of brevilaterin B: an amphiphilic lipopeptide targeting the membrane of Listeria monocytogenes	20
Towards rare earth element recovery from wastewaters: biosorption using phototrophic organisms	20
Pathway engineering facilitates efficient protein expression in Pichia pastoris	20
Distinct bacterial communities in the environmental water, sediment and intestine between two crayfish-plant coculture ecosystems	20
Unravelling the multi-faceted regulatory role of polyamines in plant biotechnology, transgenics and secondary metabolomics	20
Autotrophic lactate production from H2 + CO2 using recombinant and fluorescent FAST-tagged Acetobacterium woodii strains	20
Cold plasma surface treatments to prevent biofilm formation in food industries and medical sectors	20
Comparative analysis of gut microbial composition and potential functions in captive forest and alpine musk deer	20
Thiamine-producing lactic acid bacteria and their potential use in the prevention of neurodegenerative diseases	20
Diagnosis of histoplasmosis: current status and perspectives	20
Characterization of a Bacillus megaterium strain with metal bioremediation potential and in silico discovery of novel cadmium binding motifs in the regulator, CadC	20
Amyloid peptides with antimicrobial and/or microbial agglutination activity	20
A MALDI-TOF MS database for fast identification of Vibrio spp. potentially pathogenic to marine mollusks	20
Bio-oil production for biodiesel industry by Yarrowia lipolytica from volatile fatty acids in two-stage batch culture	20
Challenges and opportunities in producing high-quality edible mushrooms from lignocellulosic biomass in a small scale	20
Predicted functional genes for the biodegradation of xenobiotics in groundwater and sediment at two contaminated naval sites	19
Research progress on gut microbiota in patients with gastric cancer, esophageal cancer, and small intestine cancer	19
Recent advances in the discovery of novel marine natural products and mycosporine-like amino acid UV-absorbing compounds	19
Enhancing PUFA-rich polar lipids in Tisochrysis lutea using adaptive laboratory evolution (ALE) with oscillating thermal stress	19
Cell culture–based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system	19
Elicitation of biomolecules as host defense arsenals during insect attacks on tea plants (Camellia sinensis (L.) Kuntze)	19
Fungal production of kojic acid and its industrial applications	19
Mechanisms of interactions between bacteria and bacteriophage mediate by quorum sensing systems	19
Solutions against emerging infectious and noninfectious human diseases through the application of baculovirus technologies	19
Enrichment of beneficial rhizosphere microbes in Chinese wheat yellow mosaic virus-resistant cultivars	19
Transformed tissue of Dionaea muscipula J. Ellis as a source of biologically active phenolic compounds with bactericidal properties	19
Enhanced human lysozyme production by Pichia pastoris via periodic glycerol and dissolved oxygen concentrations control	19
Enhancing β-alanine production from glucose in genetically modified Corynebacterium glutamicum by metabolic pathway engineering	19
Synergism between metallic nanoparticles and antibiotics	19
Gut microbiota affect the formation of calcium oxalate renal calculi caused by high daily tea consumption	19
Plague vaccines: new developments in an ongoing search	19
The roles of DNA methylation on the promotor of the Epstein–Barr virus (EBV) gene and the genome in patients with EBV-associated diseases	19
Application of the mushroom volatile 1-octen-3-ol to suppress a morel disease caused by Paecilomyces penicillatus	19
Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria	19
Toward the future of OECD/ISO biodegradability testing-new approaches and developments	19
The effect of different combinations of antibiotic cocktails on mice and selection of animal models for further microbiota research	19
Biohybrid membranes for effective bacterial vehiculation and simultaneous removal of hexavalent chromium (CrVI) and phenol	19
Marine microbial L-glutaminase: from pharmaceutical to food industry	18
From the culture broth to the erythritol crystals: an opportunity for circular economy	18
Mixotrophic bacteria for environmental detoxification of contaminated waste and wastewater	18
Cyclophilin A: a key player for etiological agent infection	18
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes	18
Characterization of a broad-spectrum endolysin LysSP1 encoded by a Salmonella bacteriophage	18
Gut microbiome and aging nexus and underlying mechanism	18
Microorganisms: crucial players of smokeless tobacco for several health attributes	18
High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification	18
Heterologous expression of a cryptic gene cluster from Marinomonas fungiae affords a novel tricyclic peptide marinomonasin	18
Microbial electrosynthesis of methane and acetate—comparison of pure and mixed cultures	18
Highly mercury-resistant strains from different Colombian Amazon ecosystems affected by artisanal gold mining activities	18