Applied Microbiology and Biotechnology

Article	Citations
Microplastics provide new microbial niches in aquatic environments	207
The microbial coinfection in COVID-19	191
Detection technologies and recent developments in the diagnosis of COVID-19 infection	189
Crosstalk between ER stress, NLRP3 inflammasome, and inflammation	132
Industrial biotechnology of Pseudomonas putida: advances and prospects	124
Methods for detection of viable foodborne pathogens: current state-of-art and future prospects	123
Role of probiotics to combat viral infections with emphasis on COVID-19	115
Recent advances and new strategies on leishmaniasis treatment	100
Application of artificial intelligence models and optimization algorithms in plant cell and tissue culture	97
Protective effect of baicalin on the regulation of Treg/Th17 balance, gut microbiota and short-chain fatty acids in rats with ulcerative colitis	95
Microbial astaxanthin biosynthesis: recent achievements, challenges, and commercialization outlook	87
Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics	86
The potential of Akkermansia muciniphila in inflammatory bowel disease	84
Indole-3-acetic acid biosynthesis and its regulation in plant-associated bacteria	81
Novel unexpected functions of PHA granules	80
Biotechnology of Rhodococcus for the production of valuable compounds	79
Wood-water relationships and their role for wood susceptibility to fungal decay	77
Several ways one goal—methanogenesis from unconventional substrates	77
Lactobacillus plantarum NA136 ameliorates nonalcoholic fatty liver disease by modulating gut microbiota, improving intestinal barrier integrity, and attenuating inflammation	74
Auxins of microbial origin and their use in agriculture	72
Production of bioactive plant secondary metabolites through in vitro technologies—status and outlook	68
Successive use of microorganisms to remove chromium from wastewater	67
A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress–induced depressive-like behavior in mice by regulating gut microbiota and metabolites	64
Fungal bioremediation of soil co-contaminated with petroleum hydrocarbons and toxic metals	63
Bacillus as a source of phytohormones for use in agriculture	58

Iron and zinc ions, potent weapons against multidrug-resistant bacteria	58
Lizhong decoction ameliorates ulcerative colitis in mice via modulating gut microbiota and its metabolites	58
Health benefits of xylitol	56
Green synthesis of multipurpose carbon quantum dots from red cabbage and estimation of their antioxidant potential and bio-labeling activity	56
Current advances on waste biomass transformation into value-added products	56
The role of microorganisms on biotransformation of brewers’ spent grain	55
Biogenesis of silver nanoparticles to treat cancer, diabetes, and microbial infections: a mechanistic overview	55
Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets	53
Transaminases for industrial biocatalysis: novel enzyme discovery	53
Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story	53
Unraveling microbial fermentation features in kimchi: from classical to meta-omics approaches	51
(Bio)Technological aspects of microalgae pigments for cosmetics	51
Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials	50
Engineering intracellular malonyl-CoA availability in microbial hosts and its impact on polyketide and fatty acid synthesis	50
Advances on the in vivo and in vitro glycosylations of flavonoids	50
Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae	49
Motility of Vibrio spp.: regulation and controlling strategies	47
Echinocandins: structural diversity, biosynthesis, and development of antimycotics	47
Catalytically-active inclusion bodies for biotechnology—general concepts, optimization, and application	46
Alterations of Akkermansia muciniphila in the inflammatory bowel disease patients with washed microbiota transplantation	46
Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections	46
Lipid metabolism of the oleaginous yeast Lipomyces starkeyi	46
Current status on the biodegradability of acrylic polymers: microorganisms, enzymes and metabolic pathways involved	46
Campylobacter sp.: Pathogenicity factors and prevention methods—new molecular targets for innovative antivirulence drugs?	45
Mannitol: physiological functionalities, determination methods, biotechnological production, and applications	45
Mannosylerythritol lipids: dual inhibitory modes against Staphylococcus aureus through membrane-mediated apoptosis and biofilm disruption	44
Mechanisms of bactericidal action and resistance of polymyxins for Gram-positive bacteria	44
Progress in bioleaching: part B, applications of microbial processes by the minerals industries	44
Administration of Bifidobacterium bifidum CGMCC 15068 modulates gut microbiota and metabolome in azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced colitis-associated colon cancer (CAC) in mice	43
Distillers’ dried grains with solubles (DDGS) and its potential as fermentation feedstock	43
Impacts of biofilms on the conversion of cellulose	43
Plant growth promotion by Pseudomonas putida KT2440 under saline stress: role of eptA	42
Engineering of the unfolded protein response pathway in Pichia pastoris: enhancing production of secreted recombinant proteins	42
Riboflavin-overproducing lactobacilli for the enrichment of fermented soymilk: insights into improved nutritional and functional attributes	42
Anaerobic biodegradation of phenol in wastewater treatment: achievements and limits	41
Antimicrobial activities of plasma-functionalized liquids against foodborne pathogens on grass carp (Ctenopharyngodon Idella)	40
Catechin isolated from cashew nut shell exhibits antibacterial activity against clinical isolates of MRSA through ROS-mediated oxidative stress	40
The “beauty in the beast”—the multiple uses of Priestia megaterium in biotechnology	40
Biofilm formation and inhibition mediated by bacterial quorum sensing	39
Progress in bioleaching: fundamentals and mechanisms of microbial metal sulfide oxidation – part A	39
Lactobacillus plantarum FRT10 alleviated high-fat diet–induced obesity in mice through regulating the PPARα signal pathway and gut microbiota	38
Novel mycosynthesis of Co3O4, CuO, Fe3O4, NiO, and ZnO nanoparticles by the endophytic Aspergillus terreus and evaluation of their antioxidant and antimicrobial activities	38
Edible mushroom industry in China: current state and perspectives	38
Microbial single-cell omics: the crux of the matter	38
The research of aptamer biosensor technologies for detection of microorganism	37
In vitro antifungal activity of Cinnamomum zeylanicum bark and leaf essential oils against Candida albicans and Candida auris	37
Valorisation of pectin-rich agro-industrial residues by yeasts: potential and challenges	37
Streptomycetes as platform for biotechnological production processes of drugs	37
Quorum sensing inhibition and tobramycin acceleration in Chromobacterium violaceum by two natural cinnamic acid derivatives	37
An overview and future prospects on aptamers for food safety	37

Gut microbiome analysis as a predictive marker for the gastric cancer patients	37
The role of melanins in melanotic fungi for pathogenesis and environmental survival	37
Biotechnological advancements in Catharanthus roseus (L.) G. Don	36
Computation-aided engineering of starch-debranching pullulanase from Bacillus thermoleovorans for enhanced thermostability	36
Production of the anticancer drug taxol by the endophytic fungus Epicoccum nigrum TXB502: enhanced production by gamma irradiation mutagenesis and immobilization technique	36
Therapeutic and biotechnological applications of substrate specific microbial aminopeptidases	36
Responses of soil bacterial and fungal communities to the long-term monoculture of grapevine	36
The interaction of Akkermansia muciniphila with host-derived substances, bacteria and diets	36
Biotechnology progress for removal of indoor gaseous formaldehyde	36
Biosynthesis and regulation of anthocyanin pathway genes	36
Modeling and optimizing callus growth and development in Cannabis sativa using random forest and support vector machine in combination with a genetic algorithm	35
Hairy root culture technology: applications, constraints and prospect	35
Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain–based vaccine candidate, RBD219-N1C1	35
Sequential fed-batch fermentation of 1,3-propanediol from glycerol by Clostridium butyricum DL07	34
The periodic table of fermented foods: limitations and opportunities	34
Soy bioactive peptides and the gut microbiota modulation	34
Anti-fungal properties and mechanisms of melittin	34
The multifunctional lifestyles of Metarhizium: evolution and applications	34
Development of chitosan-coated agar-gelatin particles for probiotic delivery and targeted release in the gastrointestinal tract	34
Smart drug delivery against Helicobacter pylori: pectin-coated, mucoadhesive liposomes with antiadhesive activity and antibiotic cargo	34
L-asparaginase production review: bioprocess design and biochemical characteristics	34
Isolation and application of bacteriophages alone or in combination with nisin against planktonic and biofilm cells of Staphylococcus aureus	33
Sordaria macrospora: 25 years as a model organism for studying the molecular mechanisms of fruiting body development	33
Flavin-dependent N-hydroxylating enzymes: distribution and application	33
De novo biosynthesis of complex natural product sakuranetin using modular co-culture engineering	33
Multidisciplinary characterization of melanin pigments from the black fungus Cryomyces antarcticus	33
Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer	33
Microorganisms populating the water-related indoor biome	33
Assessment of overall microbial community shift during Cheddar cheese production from raw milk to aging	32
Establishment of CRISPR interference in Methylorubrum extorquens and application of rapidly mining a new phytoene desaturase involved in carotenoid biosynthesis	32
Probiotic and nutritional effects of Debaryomyces hansenii on animals	32
Fungal secondary metabolites in food and pharmaceuticals in the era of multi-omics	32
Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE−/− mice through modulation of proinflammatory cytokines and oxidative stress	32
Phenotypic and molecular insights into heat tolerance of formulated cells as active ingredients of fungal insecticides	32
Compound Lactobacillus sp. administration ameliorates stress and body growth through gut microbiota optimization on weaning piglets	32
Synthesis, biomedical applications, and toxicity of CuO nanoparticles	32
Biodegradation of fipronil: current state of mechanisms of biodegradation and future perspectives	32
Living with sulfonamides: a diverse range of mechanisms observed in bacteria	32
Microbial acetylcholinesterase inhibitors for Alzheimer’s therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery	32
Characterization of a novel xylanase from an extreme temperature hot spring metagenome for xylooligosaccharide production	32
Surfactin and fengycin B extracted from Bacillus pumilus W-7 provide protection against potato late blight via distinct and synergistic mechanisms	32
Release mechanisms and molecular interactions of Pseudomonas aeruginosa extracellular DNA	32
Comparative methods for fecal sample storage to preserve gut microbial structure and function in an in vitro model of the human colon	32
A comparative study of microbial community and functions of type 2 diabetes mellitus patients with obesity and healthy people	31
Production of multiple bacteriocins, including the novel bacteriocin gassericin M, by Lactobacillus gasseri LM19, a strain isolated from human milk	31
Adaptive laboratory evolution of Yarrowia lipolytica improves ferulic acid tolerance	31
Current view on novel vaccine technologies to combat human infectious diseases	31
Progress of cationic gene delivery reagents for non-viral vector	31
D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity	31
Desiccation-induced cell damage in bacteria and the relevance for inoculant production	31
An overview on marine cellulolytic enzymes and their potential applications	31
The influence of phosphorus source and the nature of nitrogen substrate on the biomass production and lipid accumulation in oleaginous Mucoromycota fungi	31
Sugar alcohols derived from lactose: lactitol, galactitol, and sorbitol	30
Thanatomicrobiome and epinecrotic community signatures for estimation of post-mortem time interval in human cadaver	30
Lactobacillus salivarius LI01 encapsulated in alginate-pectin microgels ameliorates d-galactosamine-induced acute liver injury in rats	30
Possible mechanisms for the equilibrium of ACC and role of ACC deaminase-producing bacteria	30
Characterization and function of membrane vesicles in Gram-positive bacteria	30
Quorum sensing signal autoinducer-2 promotes root colonization of Bacillus velezensis SQR9 by affecting biofilm formation and motility	30
Gut microbiota profiles and characterization of cultivable fungal isolates in IBS patients	30
Bacterial catabolism of indole-3-acetic acid	30
Biotechnological production of lycopene by microorganisms	29
The impact of metal pipe materials, corrosion products, and corrosion inhibitors on antibiotic resistance in drinking water distribution systems	29
Perspectives for the microbial production of ethyl acetate	29
Perspective on the biotechnological production of bacterial siderophores and their use	29
Anti-Salmonella mode of action of natural l-phenyl lactic acid purified from Lactobacillus plantarum ZJ316	29
Performance of an acoustic settler versus a hollow fiber–based ATF technology for influenza virus production in perfusion	29
Pecularities and applications of aryl-alcohol oxidases from fungi	29
Rice-shrimp culture: a better intestinal microbiota, immune enzymatic activities, and muscle relish of crayfish (Procambarus clarkii) in Sichuan Province	28
Natural bacterial isolates as an inexhaustible source of new bacteriocins	28
Processes and purposes of extraction of grape components during winemaking: current state and perspectives	28
Antifungal mechanism of 1-nonanol against Aspergillus flavus growth revealed by metabolomic analyses	28
Enterobacteriaceae in food safety with an emphasis on raw milk and meat	28
Yeast metabolic engineering for the production of pharmaceutically important secondary metabolites	28
Optimization of nitric oxide donors for investigating biofilm dispersal response in Pseudomonas aeruginosa clinical isolates	27
Orange peel waste–based liquid medium for biodiesel production by oleaginous yeasts	27
Drug repurposing strategies in the development of potential antifungal agents	27
Towards control of cellulose biosynthesis by Komagataeibacter using systems-level and strain engineering strategies: current progress and perspectives	27
The effect of bile acids on the growth and global gene expression profiles in Akkermansia muciniphila	27
Current advance in biological production of short-chain organic acid	27
Psychrophilic enzymes: structural adaptation, pharmaceutical and industrial applications	27

Reductive soil disinfestation incorporated with organic residue combination significantly improves soil microbial activity and functional diversity than sole residue incorporation	27
Milk fermented by Lactobacillus casei CRL431 administered as an immune adjuvant in models of breast cancer and metastasis under chemotherapy	27
Modifications of diketopiperazines assembled by cyclodipeptide synthases with cytochrome P450 enzymes	27
Identification and engineering a C4-dicarboxylate transporter for improvement of malic acid production in Aspergillus niger	27
Itaconic acid derivatives: structure, function, biosynthesis, and perspectives	26
Bacillus subtilis High Cell Density Fermentation Using a Sporulation-Deficient Strain for the Production of Surfactin	26
Sporulation in solventogenic and acetogenic clostridia	26
Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses	26
Global transcriptional analysis of Geobacter sulfurreducens under palladium reducing conditions reveals new key cytochromes involved	26
Introducing a hybrid artificial intelligence method for high-throughput modeling and optimizing plant tissue culture processes: the establishment of a new embryogenesis medium for chrysanthemum, as a	26
Origins and features of pectate lyases and their applications in industry	26
Synthesis and production of steviol glycosides: recent research trends and perspectives	26
Antifungal activity of silver nanoparticles synthesized by iturin against Candida albicans in vitro and in vivo	25
Development of thermostable sucrose phosphorylase by semi-rational design for efficient biosynthesis of alpha-D-glucosylglycerol	25
Harmful effects of metal(loid) oxide nanoparticles	25
Changes in microbial community in the presence of oil and chemical dispersant and their effects on the corrosion of API 5L steel coupons in a marine-simulated microcosm	25
Ligilactobacillus salivarius functionalities, applications, and manufacturing challenges	25
Towards sustainable agriculture: rhizosphere microbiome engineering	25
Enzymatic pretreatment and anaerobic co-digestion as a new technology to high-methane production	25
Bacillibactin class of siderophore antibiotics from a marine symbiotic Bacillus as promising antibacterial agents	25
One-pot platform for rapid detecting virus utilizing recombinase polymerase amplification and CRISPR/Cas12a	25
The strategies to reduce cost and improve productivity in DHA production by Aurantiochytrium sp.: from biochemical to genetic respects	25
Potential anti-TB investigational compounds and drugs with repurposing potential in TB therapy: a conspectus	25
OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potential	25
A re-evaluation of diastatic Saccharomyces cerevisiae strains and their role in brewing	25
Thermostable lipases and their dynamics of improved enzymatic properties	25
Exploiting endophytic microbes as micro-factories for plant secondary metabolite production	25
Glycerol monolaurate improves performance, intestinal development, and muscle amino acids in yellow-feathered broilers via manipulating gut microbiota	25
Expression of a β-glucosidase in bacteria with biotechnological interest confers them the ability to deglycosylate lignans and flavonoids in vegetal foods	24
Thermostability engineering of industrial enzymes through structure modification	24
Biotransformation ability of endophytic fungi: from species evolution to industrial applications	24
New insights in pectinase production development and industrial applications	24
Biotransformation of bisphenol A analogues by the biphenyl-degrading bacterium Cupriavidus basilensis - a structure-biotransformation relationship	24
Elevation rather than season determines the assembly and co-occurrence patterns of soil bacterial communities in forest ecosystems of Mount Gongga	24
Machine learning: its challenges and opportunities in plant system biology	24
Potential role of IFN-α in COVID-19 patients and its underlying treatment options	24
Biotechnological strategies for the sustainable production of diosgenin from Dioscorea spp.	24
Transcriptional changes involved in inhibition of biofilm formation by ε-polylysine in Salmonella Typhimurium	24
High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cells	24
Bacillus coagulans SANK 70258 suppresses Enterobacteriaceae in the microbiota of ulcerative colitis in vitro and enhances butyrogenesis in healthy microbiota	24
Genomic and transcriptomic perspectives on mycoremediation of polycyclic aromatic hydrocarbons	24
A novel regulatory pathway consisting of a two-component system and an ABC-type transporter contributes to butanol tolerance in Clostridium acetobutylicum	24
The Great Five—an artificial bacterial consortium with antagonistic activity towards Pectobacterium spp. and Dickeya spp.: formulation, shelf life, and the ability to prevent soft rot of potato in sto	24
Assessment of ethanol tolerance of Kluyveromyces marxianus CCT 7735 selected by adaptive laboratory evolution	23
Difficidin class of polyketide antibiotics from marine macroalga-associated Bacillus as promising antibacterial agents	23
Effect of sulfate addition on carbon flow and microbial community composition during thermophilic digestion of cellulose	23
Pediococcus pentosaceus ZJUAF-4 relieves oxidative stress and restores the gut microbiota in diquat-induced intestinal injury	23
Unraveling the anti-biofilm potential of green algal sulfated polysaccharides against Salmonella enterica and Vibrio harveyi	23
In-depth understanding of molecular mechanisms of aldehyde toxicity to engineer robust Saccharomyces cerevisiae	23
Construction of lactic acid-tolerant Saccharomyces cerevisiae by using CRISPR-Cas-mediated genome evolution for efficient d-lactic acid production	23
Eco-friendly polyurethane acrylate (PUA)/natural filler-based composite as an antifouling product for marine coating	23
Bacteria associated with cockroaches: health risk or biotechnological opportunity?	23
Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota	23
Biological activity of oxadiazole and thiadiazole derivatives	23
Antifungal activity of different Xenorhabdus and Photorhabdus species against various fungal phytopathogens and identification of the antifungal compounds from X. szentirmaii	23
Antibacterial and safety tests of a flexible cold atmospheric plasma device for the stimulation of wound healing	23
An overview and future prospects of recombinant protein production in Bacillus subtilis	23
High-level expression of aryl-alcohol oxidase 2 from Pleurotus eryngii in Pichia pastoris for production of fragrances and bioactive precursors	23
Metabolic engineering of Saccharomyces cerevisiae for enhanced production of caffeic acid	23
The community compositions of three nitrogen removal wastewater treatment plants of different configurations in Victoria, Australia, over a 12-month operational period	22
Key elements and regulation strategies of NRPSs for biosynthesis of lipopeptides by Bacillus	22
A tunable l-arabinose-inducible expression plasmid for the acetic acid bacterium Gluconobacter oxydans	22
Production of bacterial cellulose from whey—current state and prospects	22
Development of a p72 trimer–based colloidal gold strip for detection of antibodies against African swine fever virus	22
Thiamine: a key nutrient for yeasts during wine alcoholic fermentation	22
Effect of quorum-sensing molecule 2-phenylethanol and ARO genes on Saccharomyces cerevisiae biofilm	22
Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb	22
Toxin-antitoxin systems and their medical applications: current status and future perspective	22
Impact of novel microbial secondary metabolites on the pharma industry	22
New knowledge about the biosynthesis of lovastatin and its production by fermentation of Aspergillus terreus	22
Development and application of a colloidal-gold dual immunochromatography strip for detecting African swine fever virus antibodies	22
A novel β-galactosidase from Klebsiella oxytoca ZJUH1705 for efficient production of galacto-oligosaccharides from lactose	22
Recent progress and trends in the analysis and identification of rhamnolipids	22
Comparative roles of three adhesin genes (adh1–3) in insect-pathogenic lifecycle of Beauveria bassiana	22
Interactive effects of light quality and culturing temperature on algal cell size, biomass doubling time, protein content, and carbohydrate content	21
Staphylococcins: an update on antimicrobial peptides produced by staphylococci and their diverse potential applications	21
Evolutionary and reverse engineering to increase Saccharomyces cerevisiae tolerance to acetic acid, acidic pH, and high temperature	21
Exploring the molecular content of CHO exosomes during bioprocessing	21
Seed coating as a delivery system for the endophyte Trichoderma koningiopsis Th003 in rice (Oryza sativa)	21
Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods	21
Fungal mutualisms and pathosystems: life and death in the ambrosia beetle mycangia	21
An overview of Trichoderma reesei co-cultures for the production of lignocellulolytic enzymes	21
Spatial and seasonal variations of sediment bacterial communities in a river-bay system in South China	21
Inducing red pigment and inhibiting citrinin production by adding lanthanum(III) ion in Monascus purpureus fermentation	21
Genetic bases for variation in structure and biological activity of trichothecene toxins produced by diverse fungi	21
Research progress and the biotechnological applications of multienzyme complex	21
Mucoromycota fungi as powerful cell factories for modern biorefinery	21
Modeling the dynamic kinetics of microbial disinfection with dissipating chemical agents—a theoretical investigation	21
Efficient production of surfactin from xylose-rich corncob hydrolysate using genetically modified Bacillus subtilis 168	21
Old yellow enzymes: structures and structure-guided engineering for stereocomplementary bioreduction	21
ARTP mutation and adaptive laboratory evolution improve probiotic performance of Bacillus coagulans	21
Current insights into the microbial degradation for butachlor: strains, metabolic pathways, and molecular mechanisms	20
New ribosome-inactivating proteins and other proteins with protein synthesis–inhibiting activities	20
Biotechnological utilization: the role of Zea mays rhizospheric bacteria in ecosystem sustainability	20
Panorama of intron dynamics and gene rearrangements in the phylum Basidiomycota as revealed by the complete mitochondrial genome of Turbinellus floccosus	20