Immunobiology

Article	Citations
Ubiquitin-specific protease 34 in macrophages limits CD8 T cell-mediated onset of vitiligo in mice	99
Novel evaluation indicators of MOG35∼55 induced experimental autoimmune encephalomyelitis in C57BL/6J mice	49
242 Does C1q modulate myelin sheath development in zebrafish?	43
164 Role of nutraceuticals in ameliorating inflammation in Alzheimer[StQuote]s disease	41
230 Interaction of factor H and factor H-related proteins with S and N proteins of SARS-CoV-2	38
130 Low Gene Copy Numbers (GCN) of complement C4 and C4A deficiency are highly significant genetic risk factors for idiopathic inflammatory myopathies and its major subgroups	36
147 Antibodies against Streptococcus pneumoniae pneumolysin correlate with modified HDL levels and complement activation markers in peripheral arterial disease patients	36
Reduced susceptibility to COVID-19 associated with ABO blood group and pre-existing anti-A and anti-B antibodies	35
CARD11 dominant negative mutation leads to altered human Natural Killer cell homeostasis	34
Maternal stress increases risk of allergic lung inflammation in adult mice	27
Higher levels of urinary extracellular vesicles and immune mediators are related to acute infection severity during the post-COVID period	27
Diversity and hallmarks of metabolites surveyed by MR1	24
Intracellular C1r impacts tumor progression and immune microenvironment in renal cancer	23
Microglial Complement C5aR1 signalling drives inflammasome mediated neuropathology in Parkinson’s disease	21
The predictive value of miR-377 and phospholipase A2 in the early diagnosis of diabetic kidney disease and their relationship with inflammatory factors	20
Cerebrospinal fluid complement system biomarkers in Alzheimer’s disease	20
Mitochondrial RNA/RIG-I promotes Caspase-1/GSDMD-mediated inflammation in sepsis-associated acute kidney injury	19
Antipyretic and anti-inflammatory effects of inosine, an active component of Kangfuxin	19
Monocyte-derived immature dendritic cells negatively regulate hepatic stellate cells in vitro by secreting IL-10	18
Decreased number of myeloid-derived suppressor cells in the placental trophoblast of gestational diabetes mellitus. Possible role of leptin	18
36 Phase 1 clinical data for single-dose subcutaneous injection of RLYB116, a C5 blocking Affibody® molecule linked to an Albumod® albumin binding domain	18
ARID1A mutation is associated with an immunosuppressive microenvironment and poor prognosis in hepatocellular carcinoma: An integrated bioinformatics analysis	18
243 Anti-GPC1 IgM activating the complement system is an effective treatment in a pancreatic ductal adenocarcinoma mouse model	17
44 Bi-specific antibodies targeting C1q and a tumor antigen activate the complement system independent of C1q-Fc interactions	17
134 Mesangial cells derived complement factor H inhibits complement activation and inflammation in IgA Nephropathy	17

221 SYNERGY-1: A Phase 1, first-in-human, randomized, double-blind, placebo-controlled safety, tolerability, immunogenicity, PK and PD study of KP104 in escalating single and multiple doses	17
51 Activation of complement in a mouse model of severe COVID-19	17
Baculovirus-mediated expression of a Helicobacter pylori protein-based multiepitope hybrid gene induces a potent B cell response in mice	16
The TLR4/NF-κB signaling pathway-mediated type 2 skewing of T helper cell in cough variant asthma was counteracted by ethanol extract of Anacyclus pyrethrum root	16
The expression of OX40 in CD4+ T cells and its association with hepatic fibrosis injury	15
The tumor- and apoptosis-associated annexin A2 is a new ligand for FHL-1 and Factor H-related proteins – annexin-bound FHR-5 enhances alternative pathway activation	15
Development of a novel dual fluorescent ELISA (FELISA) for the simultaneous quantification of C3 and C3a in biological fluids	15
A novel tool for complement activation profiling in AAV gene therapy	15
Sexual dimorphism in neutrophil function: Unveiling the discriminative nature of male and female neutrophils	15
Novel anti-clusterin monoclonals as tools for characterising clusterin expression in biofluids and tissues	14
Investigating the role of neuronally-expressed C5aR1 in motor neuron disease	13
Complement C5aR1 modulates excitatory synaptic transmission in cortical pyramidal neurons via a calcium-independent mechanism	13
The power of fusion: Tuning pharmacokinetic and pharmacodynamic properties of complement-modulating peptides and proteins via antibody engineering	13
Doxycycline inhibits MMP-9 and inactivates microglia to reduce PNN breakdown and preserve motor neurons in SOD1(G93A) mice	13
Immunomodulation in the intestinal mucosa of mice supplemented with Lactobacillus rhamnosus (ATCC 7469) and infected with Toxocara canis	12
143 A targeted binding and activation of native C3 without proteolytic cleavage induced by contact with biosurfaces	12
168 Placenta specific complement activation in mice produces preeclampsia phenotype and adversely affects fetal liver function	12
The Alzheimer’s disease-associated complement receptor 1 variant CR1*2 enhances glial phagocytosis of relevant targets and impacts neuroinflammation	12
125 Elevated expression of complement factor I in lung cancer cells associates with shorter survival – Potentially via non-canonical mechanism	12
Study of some immunological signatures and their association with COVID-19 in a sample of recovered Iraqi patients	12
116 Differential complement iC3b levels in baseline plasma of individuals at clinical high risk for psychosis	12
202 Development of ex-vivo models to study complement activation in bio-incompatibility reactions induced by extracorporeal devices	11
28 C1q binding and complement activation by the IgM Fc-core domain	10
Exploring the role of diosgenin in modulating RUNX1 and HIPK2 transcription to mitigate Primary Sjögren's Syndrome	10
204 Novel functions of complement factor H in macrophages	10
Exploring liquid-liquid phase separation-related diagnostic biomarkers in osteoarthritis based on machine learning algorithms and experiment	10
Biomarker identification for rheumatoid arthritis with inadequate response to DMARD and TNF therapies using multidimensional analyses	10
157 From parasite to therapeutic: Expression, functional characterization, and therapeutic potential of the leech-derived complement inhibitor gigastasin	10
Paraquat induces microglial cause early neuronal synaptic deficits through activation of the classical complement cascade response	10
APOE Drives Glioma Progression by Modulating CCL5/CCR5 Signaling in the Tumor Microenvironment and Inducing M2 Macrophage Polarization	9
Qufeng epimedium decoction alleviates rheumatoid arthritis through CYLD-antagonized NF-kB activation by deubiquitinating Sirt1	9
A multi-omic pipeline identifies complement as a driver of age-dependent progression in a model of multiple sclerosis	9
Single-cell RNA and TCR repertoire analysis identify markers of virus-specific T cells	9
25 A phase 2/3 study evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE	9
Identification of a novel role for the immunomodulator ILRUN in the development of several T cell subsets in mice	9
Silencing LINC01234 represses pancreatic cancer progression by inhibiting the malignant phenotypes of pancreatic cancer cells	9
67 Strategic targeting of complement to regulate neuroinflammation and synapse pruning in Alzheimer’s disease	9
Inactivation of the Complement Lectin Pathway by Candida tropicalis Secreted Aspartyl Protease-1	9
Activation of the cGAS-STING pathway by viral dsDNA leading to M1 polarization of macrophages mediates antiviral activity against hepatitis B virus	9
Unmodified γδ T cells exhibit potent antitumor activity in hepatocellular carcinoma and are enhanced by PD-L1 blockade	9
56 Complement biomarkers reflect the pathological status of neuromyelitis optica spectrum disorders	9
Identification and validation of ferroptosis-related prognostic risk model and immune landscape in hepatocellular carcinoma	9
The conversion of native C3 to C3(H2O) is contact-driven facilitated by neutrophil extracellular traps	9
Identification and validation of a novel NK cells-related signature to predict prognosis and immune microenvironment in LUAD	8
Association of anti-DFS70 positivity with disease activity in systemic lupus erythematosus, Sjögren's syndrome, and systemic sclerosis: a cross sectional study	8
66 Tumor-derived complement is required for tumor growth in syngeneic murine STK11-mutant lung adenocarcinoma	8
88 Identification and characterization of a novel complement factor I-binding protein in Pasteurella multocida	8
174 Factor H-related dimer equilibrium and kinetics revealed through novel specific ELISAs	8
A retrospective observational study to estimate the risk of HLA alloimmunization with blood transfusion: Can the risk be reduced by leucodepletion?	8
Precolostral antibody reactivity against Histophilus somni conserved proteins and Escherichia coli whole cells in stillborn and live calves	8

190 The activation of the lectin pathway serine proteases by fibrin and it’s subsequent effect in clot formation	8
42 APPARENT: A multicenter, randomized, double-blind, placebo-controlled Phase 3 study to assess the efficacy and safety of iptacopan in idiopathic (primary) immune complex-mediated membranoproliferat	8
Tumor-infiltrating lymphocytes, PD-L1, and MMR-deficiency combined characterization may identify subgroups of rectal cancer patients who would benefit from immunotherapy	8
50 Protective role of complement factor H against the development of preeclampsia	8
166 The complement system is dysregulated in long covid patients	8
103 C3d-Directed Factor H Delivers Potent and Durable Local Complement Inhibition, Disease-Modifying Efficacy, and Decreased Renal-Derived C5b-9 Without Inhibiting Systemic Complement	8
Single-cell transcriptome analysis of macrophage subpopulations contributing to chemotherapy resistance in ovarian cancer	7
Clinical significance of serum miR-98-5p in children with Mycoplasma pneumoniae infection complicated with digestive system damage	7
The vector-pathogen anti-complement evolution dictates host skin immunomodulation for multimodal Lyme disease bacterial transmission	7
Corrigendum to “Shared pyroptosis pathways and crosstalk genes underpin inflammatory links between periodontitis and atherosclerosis” [Immunobiology 230 (2025) 152880]	7
Novel quantitative ELISA reveals dynamics of pro-Factor D conversion during alternative complement pathway activation	7
Low-abundance plasma proteomics reveals NET-associated molecular signatures in rheumatoid arthritis	7
Comparison of urine and serum IgG detection ELISA for tegumentary leishmaniasis diagnosis and prognosis	7
LncRNA FENDRR/ miR-424-5p serves as a diagnostic biomarker for sepsis and its predictive value for clinical outcomes	7
Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway	7
Quantification and clustering of immune states in hepatitis B Cirrhosis	7
Estrogen ameliorates Caerulein-induced inflammatory injuries and oxidative stress in acute pancreatitis via STAT3/PGAM1 signaling	7
miR-146a-5p regulates autophagy and NLRP3 inflammasome activation in epithelial barrier damage in the in vitro cell model of ulcerative colitis through the RNF8/Notch1/mTORC1 pathway	7
V-set domain containing T-cell activation inhibitor-1 (VTCN1): A potential target for the treatment of autoimmune diseases	7
Interactions of Candida tropicalis pH-related antigen 1 with complement proteins C3, C3b, factor-H, C4BP and complement evasion	7
219 Therapy induced senescence in cancer cell lines affects complement activation and complement regulatory proteins expression	7
High expression of NF-κB inducing kinase in the bulge region of hair follicle induces tumor	7
Regulation of FOXM1 by HDAC3 Inhibition Ameliorates Macrophage Endoplasmic Reticulum stress and Apoptosis in Mycobacterium tuberculosis Infection	7
BCL3 drives an immunosuppressive tumor microenvironment in esophageal cancer by promoting M2 macrophage polarization via STAT3 activation	7
Harnessing miR-16-5p-Loaded Exosomes from Adipose-Derived Stem Cells to Restore Immune Homeostasis in SLE Patients	7
Lactobacillus rhamnosus reduces CD8+T cell mediated inflammation in patients with rheumatoid arthritis	7
TNFSF4 is a risk factor for rheumatoid arthritis but not for primary Sjögren's syndrome in the Mexican population	7
Increased Granzyme K+ CD8+ T cells and senescent subset in Behçet's disease	6
207 Crystal structure of the Factor H domains 8-14 in complex with the Factor H-recruiting peptide 5C6 validates the unprecedented domain arrangement in the central segment of Factor H	6
Calprotectin as a novel diagnostic approach to screen male infertility risk: A pilot study	6
131 Dual inhibition of the complement system and toll-like receptors prevents systemic and local kidney inflammation in mice experiencing brain death	6
GC B cell autonomous complement activation rewires cell metabolism associated with delayed class switching and altered GC dynamics	6
Immunological profile of acute Chagas disease patients infected via oral transmission and treated with Benznidazole: a two-year follow-up of immune responses	6
Higher proinflammatory responses possibly contributing to suppressed cytotoxicity in patients with COVID-19 associated mucormycosis	6
178 Complement component C1q can predict patients’ response to cisplatin depending on tumour type: A step towards personalized medicine?	6
238 Characterizations of structural and functional diversities of human complement C4A and C4B allotypes	6
Targeting C5a is beneficial in critically ill COVID-19 patients	6
227 Nomacopan as an anti-shock drug for pre-hospital treatment of traumatic hemorrhage through switching the injury phenotype to survival phenotype	6
A novel complement-based drug candidate against fungal infections with promising results in a murine model of invasive pulmonary aspergillosis	6
Silencing core circadian regulators CLOCK and BMAL1 inhibits autophagy in interstitial cells of Cajal in a gastroesophageal reflux disease model	6
The four functional segments of Factor H: Role in physiological target recognition and contribution to disease	6
183 Exploring the role of C5aR2 in neutrophil-driven autoimmune diseases: An often overlooked player in the pathogenesis of epidermolysis bullosa acquisita	6
The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion	6
216 Association of a new variant of complement regulator FHR2 with C3 glomerulopathy	6
Complement activation during the early postpartum period in healthy pregnant women	6
Renal pathology as a predictor of complement dysregulation in C3 glomerulopathy	6
Retraction notice to “Increased levels of Th17 cells are associated with non-neuronal acetylcholine in COPD patients” [Immunobiology 219(5) (2014) 392–401]	5
74 αβ T cells and complement meet again: TCR crosstalk with surface complement regulators	5
A Flow Cytometric Approach to Assess RBC-Bound IgG Antibodies in Different Age Populations	5
The impact of neutralizing anti-IFN-γ autoantibodies on GBP5 expression and monocyte dysfunction in adult-onset immunodeficiency	5
Insights into potentiation of Factor H function by the Pneumococcal surface protein C (PspC): the structure of Factor H domains 8-14 in complex with PspC	5
The involvement of oxidative stress and the TLR4/NF-κB/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia	5
Down-regulation of MLLT1 super elongation complex subunit impairs the anti-tumor activity of natural killer cells in esophageal cancer	5
Vitexin along with verapamil downregulates efflux pump P-glycoprotein in macrophages and potentiate M1 to M2 switching via TLR4-NF-κB-TNFR2 pathway in lipopolysaccharide treated mice	5
Granulomatous inflammation and hypogammaglobulinemia: Clinical conundrum of familial hemophagocytic lymphohistiocytosis type 5	5
23 Study of complement modulation by reactive oxygen species: Revision of existing in vitro data	5
Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen	5
CD46 directly engages Sp1 to control gene transcription and HIV expression in human CD4+ T cells	5
Immune activating and inhibiting effects of calcitriol on γδ T cells and NK cells	5
The alterations of blood immune subpopulations, cytokines, and metabolites in anti-acetylcholine receptor antibody-positive myasthenia gravis: a real-world, observational, high-throughput study	5
Complement C9-mediated RBC hemolysis drives microvascular obstruction via endothelial necroptosis and hemolyzed RBC aggregation in COVID-19	5
170 Increased complement activation in recipients is associated with chronic rejection after lung transplantation	5
49 The binding and kinetics of normal versus pathogenic C3 convertase autoantibodies	5
PTPN2 alleviates psoriasis by targeting the STING-STAT3 axis and restoring autophagy: in vitro and in vivo evidence	5
Targeted binding and activation of native C3 without proteolytic cleavage induced by flip/flopped cell membranes	5
CVB3 regulates Treg cell pyroptosis through the lncRNA XIST/miR-195-5p/caspase-1 molecular axis	5
Mannose receptor modulates hepatic stellate cell activation and alleviates liver fibrosis through immune-fibrotic crosstalk	5
72 Elucidation of novel exosite interactions in the activation and control of the classical pathway of complement	4
Genetic regulation of iron homeostasis in sideropenic patients with mild COVID-19 disease under a new oral iron formulation: Lessons from a different perspective	4
The oncogene ABL1 regulates the inflammatory response of innate immunity via mediating TRAF6 ubiquitination	4
15 Defining the impact of factor H, factor H-related 1, and factor H-related 5 on C3b deposition on mouse mesangial cells	4
Shared biomarkers of multi-tissue origin for primary Sjogren's syndrome and their importance in immune microenvironment alterations	4
Targeting B7-H3 in solid tumors: Development and evaluation of novel CAR-T Cell therapy	4
115 The mannose-binding lectin (MBL) in MIS-C: relationship between MBL genotype, levels, and functional activity against SARS-CoV-2	4
100 LPS O1-antigen-mediated complement-resistance of Klebsiella pneumoniae clinical isolates	4
Development and preliminary clinical verification of an immune age model based on peripheral immune cells	4
IL-37 alleviates TNF-α-induced pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes by inhibiting the NF-κB/GSDMD signaling pathway	4
Impact of gold nanoparticles (AuNPs) on eosinophils isolated from male and female individuals	4
Serological assessment of rubella immunity in Iranian children post 2019 elimination: A pilot study	4
Differential astrocyte activation by Taenia solium antigens: Specific induction of IL-10 and IL-1β by Excretory/Secretory (ES) products	4

34 Anti-tumor effect of resident macrophages bearing complement component C1q in targeted therapy with CD19- Chimeric antigen receptor (CAR)-T cell	4
Dual-phase study of CD4+CXCR4+ T cells in Mycoplasma pneumoniae pneumonia: clinical correlations in children and therapeutic exploration with tofacitinib in mice	4
213 Complement C3 deficiency enhances the effector function of CD8+ T cells and inhibits tumour growth	4
Development and evaluation of alternative pathway Factor B neoantigen assay using novel monoclonal antibodies	4
Editorial Board	4
SIRT7 affects autophagy and activation of hepatic stellate cells by regulating the acetylation level of high mobility group protein 1	4
Mucosal complement Factor B production by intestinal epithelium is required in homeostasis and response to injury	4
222 Complement Activation in Cytokine Storms Associated with COVID-19, Sepsis, and Chimeric Antigen Receptor (CAR)-T Therapy	4
Comparable cytokine release ex-vivo by whole blood from COVID-19 patients with and without non-invasive ventilation	4
Highlighting the versatility of the citrullination process	4
Prevalence of high affinity naturally occurring IgG2 antibodies against human chorionic gonadotropin and its subunits in patients with ovarian cyst	4
Editorial Board	4
113 Complement System and leptospirosis: Understanding the role of C3 during the renal fibrosis caused during chronic infection by pathogenic leptospires in murine experimental model	4
The Fc fragment of soluble IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement-dependent cytotoxicity	4
Limosilactobacillus fermentum modulates the gut-airway axis by improving the immune response through FOXP3 activation on combined allergic rhinitis and asthma syndrome (CARAS)	4
Factor H-related protein dysregulation and intracellular localizationin osteoarthritis and head & neck cancer	4
Editorial Board	4
Editorial Board	3
IL-9 and IL-9 receptor expression in lymphocytes from bronchoalveolar lavage fluid of patients with interstitial lung disease	3
Preface to the special issue for the 30th International Complement Workshop Brisbane 2025	3
Involvement of Xeroderma Pigmentosum Complementation Group G (XPG) in epigenetic regulation of T-Helper (TH) cell differentiation during breast cancer	3
Explore the mechanism of incomplete Kawasaki disease and identify a novel biomarker by weighted gene co-expression network analysis	3
Serological markers of rheumatoid arthritis in patients with primary biliary cholangitis and the vice versa: A Tunisian study	3
Neutrophil plasticity in epidermolysis bullosa acquisita: Bridging innate and adaptive immunity via C5aR2 signaling	3
53 Increased infiltration of CD4+ T cell in the complement deficient lymphedema model	3
Myeloperoxidase-deficient mice exposed to Zymosan exhibit severe neutrophilia and anemia with enhanced granulopoiesis and reduced erythropoiesis, accompanied by pulmonary inflammation	3
Physiological estrogen levels are dispensable for the sex difference in immune responses during allergen-induced airway inflammation	3
T helper type 9 cell response and its role in the neurological clinic of patients with Human T-lymphotropic virus 1	3
Distinct sites of complement activation and regulation in the tumor microenvironment	3
105 Elucidating the role of anaphylatoxins and their receptors in osteoarthritis regarding cartilage calcification	3
Associations of HLA-G 3’UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis	3
Integrated analyses uncover new features of atypical memory B cells and novel targets for intervention	3
Aberrant expression of JMJD3 in SLE promotes B-cell differentiation	3
CD8 T lymphocytes from B-1 cell-deficient mice down-regulates fungicidal activity of macrophages challenged with E. Cuniculi	3
Irisin attenuates fine particulate matter induced acute lung injury by regulating Nod2/NF-κB signaling pathway	3
193 Iptacopan (LNP023) inhibits activity of FB mutants identified in patients with atypical hemolytic uremic syndrome (aHUS)	3
Complement signaling as a T-cell checkpoint in the tumor microenvironment	3
70 C5a receptor 1 controls antigen and TLR-driven T cell proliferation and differentiation by splenic conventional type 2 dendritic cells	3
Peripheral changes in T cells predict efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer	3
IL-27 regulates autophagy in rheumatoid arthritis fibroblast-like synoviocytes via STAT3 signaling	3
Transcriptional cross-talk regulates complement C3 expression during CD4+ T-cell activation	3
The utility of inflammatory and endothelial factors in the prognosis of severe dengue	3
Highlighting the changes of the Lymphocyte-to-Monocyte ratio in B-cell non-Hodgkin Lymphoma with the treatment and its association with the FLT3/FLT3LG system	3
MiR-210 suppresses Candida albicans-derived β-glucan-induced inflammation in THP-1-derived macrophages via the Syk-NF-κB pathway	3
Effects of cannabinoid receptor-1 antagonist MRI-1867 on C5ar1 signaling in attenuating lung remodeling in mice induced with experimental arthritis	3
The protective effect of total glucosides of white paeony capsules on experimental autoimmune encephalomyelitis	3
HMGB1 regulates the activation of dendritic cells and CD4+ T cell responses through the modulation of autophagy in bleomycin-induced pulmonary fibrosis	3
Editorial Board	3
Insights into IL-33 on inflammatory response during in vitro infection by Trypanosoma cruzi	3
Mapping inhibitory epitopes on C7 with monoclonal antibodies	3
153 Visualizing complement activation and regulation in the tumor microenvironment	3
80 C5b-9 and Bb factor levels as potential novel biomarkers in crescentic IgA nephropathy	3
Macrophage Migration Inhibitory Factor contributes to drive phenotypic and functional macrophages activation in response to Toxoplasma gondii infection	3
CCR1 antagonist J-113863 corrects the imbalance of pro- and anti-inflammatory cytokines in a SJL/J mouse model of relapsing-remitting multiple sclerosis	3
Novel functions of CD59 isoforms IRIS-1 and IRIS-2 in insulin-producing pancreatic β-cells	3
Ureaplasma urealyticum GrpE protein elicits glycolysis-mediated inflammatory responses through TLR2 in macrophages	3