Advanced Drug Delivery Reviews

Article	Citations
Liposome composition in drug delivery design, synthesis, characterization, and clinical application	369
Self-assembled mRNA vaccines	275
The role of lipid components in lipid nanoparticles for vaccines and gene therapy	267
COVID-19 vaccines: The status and perspectives in delivery points of view	254
To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives	197
Supramolecular engineering of hydrogels for drug delivery	193
Overcoming barriers by local drug delivery with liposomes	187
Pharmaceutical electrospinning and 3D printing scaffold design for bone regeneration	180
DNA hydrogel-based gene editing and drug delivery systems	177
Recombinant protein vaccines, a proven approach against coronavirus pandemics	168
Translating 3D printed pharmaceuticals: From hype to real-world clinical applications	165
Non-viral COVID-19 vaccine delivery systems	156
RNAi-based therapeutics and tumor targeted delivery in cancer	155
Dosing extracellular vesicles	153
Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers	146
Connected healthcare: Improving patient care using digital health technologies	145
Fibronectin in development and wound healing	144
Nucleic acid delivery for therapeutic applications	140
Frontiers in the treatment of glioblastoma: Past, present and emerging	138
Advances in powder bed fusion 3D printing in drug delivery and healthcare	135
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation	134
Peptide and peptide-based inhibitors of SARS-CoV-2 entry	133
Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis	130
Rational designs of in vivo CRISPR-Cas delivery systems	125
Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment	123

Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites	120
Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy	120
Machine learning directed drug formulation development	118
Clinical translation of nanomedicines: Challenges, opportunities, and keys	117
Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery	115
Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies	114
Antimicrobial peptides towards clinical application: Delivery and formulation	111
Nanoscale MOFs: From synthesis to drug delivery and theranostics applications	110
(Macro)molecular self-assembly for hydrogel drug delivery	105
Approaches to surface engineering of extracellular vesicles	103
Peptide-based supramolecular hydrogels for local drug delivery	103
Engineering the drug carrier biointerface to overcome biological barriers to drug delivery	103
Technology insight: Plant-derived vesicles—How far from the clinical biotherapeutics and therapeutic drug carriers?	100
Targeting drug delivery with light: A highly focused approach	98
Polymeric drug delivery systems by additive manufacturing	98
Emerging 3D printing technologies for drug delivery devices: Current status and future perspective	97
Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment	97
Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies	95
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives	94
Topical drug delivery: History, percutaneous absorption, and product development	93
Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities	91
Near-infrared fluorescence imaging in immunotherapy	90
The effects of protein corona on in vivo fate of nanocarriers	89
Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis	89
Harnessing artificial intelligence for the next generation of 3D printed medicines	89
Challenges of fused deposition modeling 3D printing in pharmaceutical applications: Where are we now?	89
Biomedical engineering of two-dimensional MXenes	88
Predicting bioavailability of monoclonal antibodies after subcutaneous administration: Open innovation challenge	88
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network	87
Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases	87
Delivery of STING agonists for adjuvanting subunit vaccines	86
Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance	84
Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants	83
Microneedle-Mediated Vaccination: Innovation and Translation	82
Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms	81
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health	81
Clinically established biodegradable long acting injectables: An industry perspective	81
An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers	80
Why nanoparticles prefer liver macrophage cell uptake in vivo	80
Let’s talk about sex: Differences in drug therapy in males and females	79
Mesoporous silica nanoparticles for pulmonary drug delivery	79
Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery	78
Vaccine delivery systems toward lymph nodes	77
Photodynamic and antibiotic therapy in combination against bacterial infections: efficacy, determinants, mechanisms, and future perspectives	76
Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic	76
A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos	76
Biomembrane-based nanostructures for cancer targeting and therapy: From synthetic liposomes to natural biomembranes and membrane-vesicles	76
Target specific tight junction modulators	75
Technological advances towards extracellular vesicles mass production	75
Advances in gene-based vaccine platforms to address the COVID-19 pandemic	74

Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems	73
SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?	72
The past, present, and future of breast cancer models for nanomedicine development	72
Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis	72
Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential	71
Imaging technology of the lymphatic system	71
The in vivo fate of polymeric micelles	70
Dawn of lipid nanoparticles in lymph node targeting: Potential in cancer immunotherapy	70
Targeting the blood-brain barrier for the delivery of stroke therapies	70
3D printing as a transformative tool for microneedle systems: Recent advances, manufacturing considerations and market potential	70
Nanocarrier vaccines for SARS-CoV-2	70
Separation, characterization, and standardization of extracellular vesicles for drug delivery applications	69
Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design	68
Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives	67
Scaled preparation of extracellular vesicles from conditioned media	67
Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years	67
Nanomedicine for brain cancer	67
Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms	67
Shape memory materials and 4D printing in pharmaceutics	66
Novel antimicrobial agents for combating antibiotic-resistant bacteria	66
Tumor microenvironment-responsive dynamic inorganic nanoassemblies for cancer imaging and treatment	65
Clinical translation of advanced colonic drug delivery technologies	65
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine	65
2D materials-based nanomedicine: From discovery to applications	64
Cell-penetrating peptides in protein mimicry and cancer therapeutics	64
Pharmaceutical applications of powder-based binder jet 3D printing process – A review	64
Engineering interferons and interleukins for cancer immunotherapy	63
Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy	63
High-throughput proteomics and AI for cancer biomarker discovery	63
In situ activation of therapeutics through bioorthogonal catalysis	62
Smart gating porous particles as new carriers for drug delivery	62
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across	62
α-Amino acid N-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery	62
Stealth and pseudo-stealth nanocarriers	61
Advancing pharmacy and healthcare with virtual digital technologies	61
Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome	61
Tumor-on-chip modeling of organ-specific cancer and metastasis	61
Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders	60
Stabilizers and their interaction with formulation components in frozen and freeze-dried protein formulations	60
Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities	60
Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection	60
Advances in mRNA non-viral delivery approaches	60
Defensins: The natural peptide antibiotic	60
Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models	59
Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants	59
Metal-organic frameworks for therapeutic gas delivery	58
Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting	57
Bacterial extracellular vesicles: Understanding biology promotes applications as nanopharmaceuticals	57
Self-assembly of protein-polymer conjugates for drug delivery	57
Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines	57
Responsive optical probes for deep-tissue imaging: Photoacoustics and second near-infrared fluorescence	56
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders	56
Nanovaccines with cell-derived components for cancer immunotherapy	55
Dry powder pharmaceutical biologics for inhalation therapy	55
Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors	55
Decorated bacteria and the application in drug delivery	54
Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach	54
Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma	54
The promising interplay between sonodynamic therapy and nanomedicine	54
A quantitative view on multivalent nanomedicine targeting	54
In silico T cell epitope identification for SARS-CoV-2: Progress and perspectives	54
Bioinspired drug delivery strategies for repurposing conventional antibiotics against intracellular infections	53
Automation and data-driven design of polymer therapeutics	53
Electroactive material-based biosensors for detection and drug delivery	53
Extracellular vesicles as antigen carriers for novel vaccination avenues	53
Stability of lyophilized and spray dried vaccine formulations	53
Nucleic acid delivery with extracellular vesicles	53
Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing	53
A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing	53
Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)	52
Nano-delivery to the lung - by inhalation or other routes and why nano when micro is largely sufficient?	52
Nanotechnology-empowered vaccine delivery for enhancing CD8+ T cells-mediated cellular immunity	52
Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract	51
Extracellular vesicles as delivery systems at nano-/micro-scale	51
Autophagy in the cancer-immunity dialogue	51
Integration of personalized drug delivery systems into digital health	50
Engineering of stimuli-responsive self-assembled biomimetic nanoparticles	50
Emerging strategies in developing multifunctional nanomaterials for cancer nanotheranostics	50
Listening to drug delivery and responses via photoacoustic imaging	50
Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers	49

Synthetic multi-layer nanoparticles for CRISPR-Cas9 genome editing	49
Advances and future perspectives in epithelial drug delivery	49
Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs – EVOLVE France”	49
Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches – An overview	48
Rationally designed drug delivery systems for the local treatment of resected glioblastoma	48
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound	48
Modulating the foreign body response of implants for diabetes treatment	47
Two-Dimensional Nanomaterial-based catalytic Medicine: Theories, advanced catalyst and system design	47
Formulation strategies to improve the efficacy of intestinal permeation enhancers,	47
Human skin equivalents: Impaired barrier function in relation to the lipid and protein properties of the stratum corneum	47
Development and aging of the lymphatic vascular system	47
Delivering more for less: nanosized, minimal-carrier and pharmacoactive drug delivery systems	46
Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases	46
GO-based antibacterial composites: Application and design strategies	46
Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages	46
Microarray patches enable the development of skin-targeted vaccines against COVID-19	46
Gene- and RNAi-activated scaffolds for bone tissue engineering: Current progress and future directions	46
Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe	46
Building three-dimensional lung models for studying pharmacokinetics of inhaled drugs	45
Ferritin nanocage: A promising and designable multi-module platform for constructing dynamic nanoassembly-based drug nanocarrier	45
Artificial intelligence to bring nanomedicine to life	45
Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing	45
Understanding molecular mechanisms of biologics drug delivery and stability from NMR spectroscopy	44
Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems	44
The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis	44
Bacterial membrane vesicles for vaccine applications	44
Mastering the Gram-negative bacterial barrier – Chemical approaches to increase bacterial bioavailability of antibiotics	44
Cell-based drug delivery systems and their in vivo fate	43
Self-assembling peptides as vectors for local drug delivery and tissue engineering applications	43
In vitro and ex vivo models in inhalation biopharmaceutical research — advances, challenges and future perspectives	43
Nucleic acid nanoparticles (NANPs) as molecular tools to direct desirable and avoid undesirable immunological effects	43
Harnessing cerebrospinal fluid circulation for drug delivery to brain tissues	43
Multifunctional plasmonic-magnetic nanoparticles for bioimaging and hyperthermia	42
Medical devices, smart drug delivery, wearables and technology for the treatment of Diabetes Mellitus	42
The RNA-binding protein HuR in human cancer: A friend or foe?	42
Targeting the tumor biophysical microenvironment to reduce resistance to immunotherapy	42
Adherence to minimal experimental requirements for defining extracellular vesicles and their functions	42
Mechanisms of immune response to inorganic nanoparticles and their degradation products	42
Role of extracellular vesicles in liver diseases and their therapeutic potential	42
Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment	42
Biomimetic immunomodulation strategies for effective tissue repair and restoration	42
Antimicrobial blue light: A ‘Magic Bullet’ for the 21st century and beyond?	42
Dynamic nanoassemblies of nanomaterials for cancer photomedicine	42
Activatable fluorescent probes for real-time imaging-guided tumor therapy	42
Recent advances in long-acting drug delivery systems for anticancer drug	41
Progress of engineered bacteria for tumor therapy	41
Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments	41
Sustained delivery approaches to improving adaptive immune responses	41
Extracellular vesicles for the treatment of central nervous system diseases	41
Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy	41
Biomaterial-based delivery of nucleic acids for tissue regeneration	41
Organ-on-a-chip technology for the study of the female reproductive system	41
Antifibrotic strategies for medical devices	41
Magnetic iron oxide nanoparticles for brain imaging and drug delivery	40
Supercritical fluid (SCF)-assisted fabrication of carrier-free drugs: An eco-friendly welcome to active pharmaceutical ingredients (APIs)	40
Applications of focused ultrasound-mediated blood-brain barrier opening	40
Jet injectors: Perspectives for small volume delivery with lasers	40
Inhalation delivery technology for genome-editing of respiratory diseases	40
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy	40
Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models	40
Particle engineering principles and technologies for pharmaceutical biologics	40
Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems	40
Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery	40
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment	39
Non-viral nanoparticles for RNA interference: Principles of design and practical guidelines	39
Artificial intelligence and machine learning assisted drug delivery for effective treatment of infectious diseases	39
Engineering and loading therapeutic extracellular vesicles for clinical translation: A data reporting frame for comparability	39
Drug release from in situ forming implants and advances in release testing	39
Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches	39
Can microorganisms develop resistance against light based anti-infective agents?	38
Challenges and solutions in polymer drug delivery for bacterial biofilm treatment: A tissue-by-tissue account	38
Mucosal drug delivery and 3D printing technologies: A focus on special patient populations	38
Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors	38
Additive manufacturing in drug delivery: Innovative drug product design and opportunities for industrial application	38
Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity	38
Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges	38
Polymers in pharmaceutical additive manufacturing: A balancing act between printability and product performance	38
Versatility on demand – The case for semi-solid micro-extrusion in pharmaceutics	38
Merging data curation and machine learning to improve nanomedicines	38
Nanotechnologies for the delivery of biologicals: Historical perspective and current landscape	37
Coiled coil-based therapeutics and drug delivery systems	37
Oral lipid nanomedicines: Current status and future perspectives in cancer treatment	37
Two-dimensional nanomaterials for tumor microenvironment modulation and anticancer therapy	37
Controlling drug release with additive manufacturing-based solutions	37
Bacteria and bacterial derivatives as delivery carriers for immunotherapy	37