Advanced Drug Delivery Reviews

Article	Citations
Drug delivery strategies in maximizing anti-angiogenesis and anti-tumor immunity	534
Leveraging the neurosurgical operating room for therapeutic development in NeuroOncology	533
Drug delivery for metabolism targeted cancer immunotherapy	322
Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound	250
Agony of choice: How anesthetics affect the composition and function of extracellular vesicles	248
Editorial board members	244
Emerging antibiotic alternatives: From antimicrobial peptides to bacteriophage therapies	242
Long-acting inhaled medicines: Present and future	238
Gene editing strategies to treat lysosomal disorders: The example of mucopolysaccharidoses	230
Deciphering albumin-directed drug delivery by imaging	217
Nanoparticle-neutrophils interactions for autoimmune regulation	213
Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art	200
Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics	198
Tools for computational design and high-throughput screening of therapeutic enzymes	195
Bacterially mediated drug delivery and therapeutics: Strategies and advancements	191
Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders	188
Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond	176
Models to study basic and applied aspects of lysosomal storage disorders	169
MIDD in Japan– Implementations, challenges and opportunities	168
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine	165
Recent advances in endocrine organoids for therapeutic application	161
Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles	158
Mastering the Gram-negative bacterial barrier – Chemical approaches to increase bacterial bioavailability of antibiotics	158
Cell membrane-coated nanoparticles for targeting carcinogenic bacteria	154
Liposomal formulations for treating lysosomal storage disorders	149

Penetration and translocation of functional inorganic nanomaterials into biological barriers	149
Therapeutic and delivery strategies of phytoconstituents for renal fibrosis	144
MicroRNAs and their delivery in diabetic fibrosis	143
Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies	139
Nanovaccines with cell-derived components for cancer immunotherapy	137
Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity	137
Biopharmaceutical drug delivery and phototherapy using protein crystals	134
Editorial/Preface	131
Emerging Voices in Drug Delivery – Harnessing and Modulating Complex Biological Systems (Issue 2)	129
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer’s disease	127
In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols	127
Editorial Board	126
Activatable dual-functional molecular agents for imaging-guided cancer therapy	126
Targeting microbiome, drug metabolism, and drug delivery in oncology	121
Drug delivery using gold nanoparticles	121
Lipid nanoparticle formulations for targeting leukocytes with therapeutic RNA in liver fibrosis	120
Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics	118
Exosome- and extracellular vesicle-based approaches for the treatment of lysosomal storage disorders	118
Role of extracellular vesicles in liver diseases and their therapeutic potential	118
From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly	118
RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer	118
Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery	113
In situ cellular hitchhiking of nanoparticles for drug delivery	112
Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases	112
Synthetic biology-guided design and biosynthesis of protein polymers for delivery	112
Separation, characterization, and standardization of extracellular vesicles for drug delivery applications	112
Novel strategies for modulating the gut microbiome for cancer therapy	109
Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches	109
Ultrasonic particles: An approach for targeted gene delivery	109
Physical methods for enhancing drug absorption from the gastrointestinal tract	106
Strategies to develop polymeric microneedles for controlled drug release	105
3D printing of drug delivery systems enhanced with micro/nano-technology	105
Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems	103
Solid implantable devices for sustained drug delivery	102
Activatable fluorescent probes for real-time imaging-guided tumor therapy	102
Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications	101
Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers	100
Engineering bacterial membrane nanovesicles for improved therapies in infectious diseases and cancer	99
Phytonanomaterials as therapeutic agents and drug delivery carriers	99
Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system	99
Lysosomal therapies and drug delivery strategies: An overview	99
Nanosensitizer-mediated unique dynamic therapy tactics for effective inhibition of deep tumors	98
Hurdles in translating science from lab to market in delivery systems for Cosmetics: An industrial perspective	98
Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos	97
Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers	97
The extracellular matrix of hematopoietic stem cell niches	96
Nanobodies: Robust miniprotein binders in biomedicine	95
Model-informed precision dosing: State of the art and future perspectives	94
Modular design principle based on compartmental drug delivery systems	94
Micro-patterned cell populations as advanced pharmaceutical drugs with precise functional control	94

Engineering complexity in human tissue models of cancer	94
Vaginal drug delivery approaches for localized management of cervical cancer	94
Technological and translational challenges for extracellular vesicle in therapy and diagnosis	94
Soft nano and microstructures for the photomodulation of cellular signaling and behavior	93
Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases	93
Tumour extravasation of nanomedicine: The EPR and alternative pathways	92
In-vitro 3D modelling for charged particle therapy – Uncertainties and opportunities	92
Drug delivery strategies for management of women’s health issues in the upper genital tract	92
Recent trends in drug-delivery systems for the treatment of diabetic retinopathy and associated fibrosis	92
Unignored intracellular journey and biomedical applications of extracellular vesicles	91
Novel drug delivery systems for the management of dry eye	91
To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives	90
Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities	90
Editorial board members	89
High-throughput proteomics and AI for cancer biomarker discovery	89
Editorial board members	89
Fit and forget: The future of dental implant therapy via nanotechnology	89
Editorial board members	88
Corrigendum to ‘Cell-penetrating peptides in protein mimicry and cancer therapeutics’ [Advanced Drug Delivery Reviews, 180 (2022), 114044]	87
Corrigendum to “Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration” [Adv. Drug Deliv. Rev. 209 (2024) 115328]	87
Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery	86
Preface: Image-assisted organoid research and application	86
Women-specific routes of administration for drugs: A critical overview	85
Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers	84
Modulating tumor physical microenvironment for fueling CAR-T cell therapy	83
Nanoparticles for local delivery of siRNA in lung therapy	82
Listening to drug delivery and responses via photoacoustic imaging	82
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease	81
Implications and pitfalls for cancer diagnostics exploiting extracellular vesicles	81
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders	80
MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration	80
Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment	80
Trends and patterns in cancer nanotechnology research: A survey of NCI's caNanoLab and nanotechnology characterization laboratory	80
Nanomedicine from amphiphilized prodrugs: Concept and clinical translation	80
Responsive nanomedicines enhanced by or enhancing physical modalities to treat solid cancer tumors: Preclinical and clinical evidence of safety and efficacy	79
Nanoparticle-based immunotherapeutics: From the properties of nanocores to the differential effects of administration routes	79
Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)	79
Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy	79
Recent progress in upconversion nanomaterials for emerging optical biological applications	79
Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy	78
Engineering and loading therapeutic extracellular vesicles for clinical translation: A data reporting frame for comparability	77
Design of disintegrable nanoassemblies to release multiple small-sized nanoparticles	76
The role of sex as a biological variable in the efficacy and toxicity of therapeutic nanomedicine	76
Dynamic nanoassembly-based drug delivery system (DNDDS): Learning from nature	75
Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness	75
Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models	75
Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery	74
Additive manufacturing in spatial patterning for spinal cord injury treatment	74
Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19	74
Can microorganisms develop resistance against light based anti-infective agents?	72
Clinical translation of advanced colonic drug delivery technologies	72
Spectral computed tomography with inorganic nanomaterials: State-of-the-art	71
Targeting fibrosis in the failing heart with nanoparticles	71
Biophotonics for diagnostic detection of extracellular vesicles	71
Blood-brain barrier delivery for lysosomal storage disorders with IgG-lysosomal enzyme fusion proteins	71
Omics approaches for the assessment of biological responses to nanoparticles	70
3D extrusion bioprinting of microbial inks for biomedical applications	69
Editorial Board	69
mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond	69
Progress of engineered bacteria for tumor therapy	69
Dry powder pharmaceutical biologics for inhalation therapy	69
Corrigendum to “Advanced theragnostics for the central nervous system (CNS) and neurological disorders using functional inorganic nanomaterials” [Adv. Drug Delivery Rev. 192 (2023) 114636]	69
Nanomedicine for the treatment of diabetes-associated cardiovascular diseases and fibrosis	68
Applications of pharmacometrics in drug development	68
Synthetic polypeptides for drug and gene delivery, and tissue engineering	68
Steric stabilization of bioactive nanoparticles using elastin-like polypeptides	68
Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo	67
Engineering stromal heterogeneity in cancer	67
Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance	67
Of devices and drugs – Ingestible bots for diagnosis and therapy	67
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound	66
Cell-penetrating peptides in protein mimicry and cancer therapeutics	66
Adherence to minimal experimental requirements for defining extracellular vesicles and their functions	66
Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics	66
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook	66
The dynamic, motile and deformative properties of RNA nanoparticles facilitate the third milestone of drug development	66
Intrathecal delivery and its applications in leptomeningeal disease	66
Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment	65
Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery	64
Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma	64

Dynamic nano-assemblies based on two-dimensional inorganic nanoparticles: Construction and preclinical demonstration	64
Local scaffold-assisted delivery of immunotherapeutic agents for improved cancer immunotherapy	64
Nanoarchitectured two-dimensional layered double hydroxides-based nanocomposites for biomedical applications	63
Microbiota and plant-derived vesicles that serve as therapeutic agents and delivery carriers to regulate metabolic syndrome	63
Advances in Salmonella Typhimurium-based drug delivery system for cancer therapy	63
Imaging drug delivery to the lungs: Methods and applications in oncology	63
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives	62
Get out or die trying: Peptide- and protein-based endosomal escape of RNA therapeutics	62
Biomaterial-based delivery of nucleic acids for tissue regeneration	62
Recent developments in lactose blend formulations for carrier-based dry powder inhalation	62
Engineering of stimuli-responsive self-assembled biomimetic nanoparticles	62
Delivery of synthetic mRNAs for tissue regeneration	61
Editorial board members	61
Progress of tumor-resident intracellular bacteria for cancer therapy	61
Extracellular vesicles as novel assay tools to study cellular interactions of anti-infective compounds – A perspective	61
Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors – An update	61
Special Issue (SI) on: Emerging pharmaceutical technologies (From advanced materials & formulations to new processes) for novel dosage development	61
Revealing the clinical potential of high-resolution organoids	60
Corrigendum to “Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic” [Adv. Drug Delivery Rev. 179 (2021) 114000]	59
Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years	59
The tendon microenvironment: Engineered in vitro models to study cellular crosstalk	58
Towards artificial intelligence-enabled extracellular vesicle precision drug delivery	58
Microbubble-assisted ultrasound for inner ear drug delivery	58
Laser ablation: Heating up the anti-tumor response in the intracranial compartment	58
Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe	57
Ocular therapies with biomacromolecules: From local injection to eyedrop and emerging noninvasive delivery strategies	57
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics	57
The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery	57
Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms	57
Microneedle-Mediated Vaccination: Innovation and Translation	56
Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment	56
Sustained delivery approaches to improving adaptive immune responses	56
Biosafety of mesoporous silica nanoparticles; towards clinical translation	56
Smart gating porous particles as new carriers for drug delivery	56
Merging data curation and machine learning to improve nanomedicines	56
Editorial board members	55
Advances in solid formulation of pharmaceutical biologics	55
Editorial board members	55
Cell-based relay delivery strategy in biomedical applications	55
Integrated pharmacokinetic-pharmacodynamic and agent-based modelling in drug development: Current status and future perspectives	54
Editorial Board	54
Editorial board members	54
Editorial board members	54
Editorial Board	54
Editorial board members	54
Next generation concepts in dermal delivery, theranostics, and preclinical testing	54
Synthetic RNA-based post-transcriptional expression control methods and genetic circuits	53
Targeted delivery methods for RNA interference are necessary to obtain a potential functional cure for HIV/AIDS	53
Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment	53
Theme issue: In vitro mucus models	53
Cellular protein markers, therapeutics, and drug delivery strategies in the treatment of diabetes-associated liver fibrosis	53
Drugging the lymphatic system: An emerging opportunity for cancer immunotherapy	53
Leveraging advances in immunopathology and artificial intelligence to analyze in vitro tumor models in composition and space	53
Advances in long-acting injectables, implants, and vaginal rings for contraception and HIV prevention	53
The past, present, and future of breast cancer models for nanomedicine development	52
Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening	52
From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer	52
Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic	52
Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles	52
Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria	52
Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids	51
Stealth and pseudo-stealth nanocarriers	51
Recent applications of three-dimensional bioprinting in drug discovery and development	51
Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling	51
Photonic and magnetic materials for on-demand local drug delivery	51
Advances in modular control of CAR-T therapy with adapter-mediated CARs	51
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health	51
Current issues in optical monitoring of drug delivery via hair follicles	51
Fungal infections: Immune defense, immunotherapies and vaccines	51
Precise subcellular targeting approaches for organelle-related disorders	51
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics	51
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation	51
Transdermal drug delivery via microneedles to mediate wound microenvironment	51
Imaging and therapeutic targeting of the tumor immune microenvironment with biologics	50
Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor	50
Editorial Board	50
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems	50
Long-acting parenteral drug delivery systems for the treatment of chronic diseases	50
Mesoporous silica nanoparticles for pulmonary drug delivery	50
The RNA-binding protein HuR in human cancer: A friend or foe?	50
Biomedical engineering of two-dimensional MXenes	50
The role of the HBCU pipeline in diversifying the STEM workforce: Training the next generation of drug delivery researchers	50
The effects of protein corona on in vivo fate of nanocarriers	50
Shape memory materials and 4D printing in pharmaceutics	49
Purified mucins in drug delivery research	49
Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease	49
Effects of nanoparticle deformability on multiscale biotransport	49
Bioengineering toolkits for potentiating organoid therapeutics	49
Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap	49