Advanced Drug Delivery Reviews

(The TQCC of Advanced Drug Delivery Reviews is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
Liposome composition in drug delivery design, synthesis, characterization, and clinical application284
COVID-19 vaccines: The status and perspectives in delivery points of view241
Self-assembled mRNA vaccines227
The role of lipid components in lipid nanoparticles for vaccines and gene therapy150
Supramolecular engineering of hydrogels for drug delivery150
Overcoming barriers by local drug delivery with liposomes149
Pharmaceutical electrospinning and 3D printing scaffold design for bone regeneration147
Non-viral COVID-19 vaccine delivery systems145
Recombinant protein vaccines, a proven approach against coronavirus pandemics144
To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives143
Translating 3D printed pharmaceuticals: From hype to real-world clinical applications136
DNA hydrogel-based gene editing and drug delivery systems136
Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers121
Frontiers in the treatment of glioblastoma: Past, present and emerging120
Peptide and peptide-based inhibitors of SARS-CoV-2 entry118
Dosing extracellular vesicles113
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation112
Advances in powder bed fusion 3D printing in drug delivery and healthcare112
Rational designs of in vivo CRISPR-Cas delivery systems112
Nucleic acid delivery for therapeutic applications110
Fibronectin in development and wound healing109
RNAi-based therapeutics and tumor targeted delivery in cancer106
Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites102
Connected healthcare: Improving patient care using digital health technologies101
Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy101
Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery98
Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis96
Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment95
Machine learning directed drug formulation development89
Clinical translation of nanomedicines: Challenges, opportunities, and keys88
Engineering the drug carrier biointerface to overcome biological barriers to drug delivery84
Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies84
Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies84
Approaches to surface engineering of extracellular vesicles83
Targeting drug delivery with light: A highly focused approach83
(Macro)molecular self-assembly for hydrogel drug delivery83
Antimicrobial peptides towards clinical application: Delivery and formulation82
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network81
Peptide-based supramolecular hydrogels for local drug delivery80
Harnessing artificial intelligence for the next generation of 3D printed medicines80
Near-infrared fluorescence imaging in immunotherapy78
Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases78
Polymeric drug delivery systems by additive manufacturing78
Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities78
Challenges of fused deposition modeling 3D printing in pharmaceutical applications: Where are we now?77
Emerging 3D printing technologies for drug delivery devices: Current status and future perspective76
Topical drug delivery: History, percutaneous absorption, and product development75
Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis75
Predicting bioavailability of monoclonal antibodies after subcutaneous administration: Open innovation challenge72
Microneedle-Mediated Vaccination: Innovation and Translation71
SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?71
Technology insight: Plant-derived vesicles—How far from the clinical biotherapeutics and therapeutic drug carriers?70
Nanoscale MOFs: From synthesis to drug delivery and theranostics applications68
Advances in gene-based vaccine platforms to address the COVID-19 pandemic67
Target specific tight junction modulators67
Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance67
Clinically established biodegradable long acting injectables: An industry perspective66
Let’s talk about sex: Differences in drug therapy in males and females66
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health65
Nanocarrier vaccines for SARS-CoV-264
Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment64
Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants64
A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos62
Biomedical engineering of two-dimensional MXenes62
Photodynamic and antibiotic therapy in combination against bacterial infections: efficacy, determinants, mechanisms, and future perspectives62
Targeting the blood-brain barrier for the delivery of stroke therapies61
Shape memory materials and 4D printing in pharmaceutics61
The past, present, and future of breast cancer models for nanomedicine development61
3D printing as a transformative tool for microneedle systems: Recent advances, manufacturing considerations and market potential61
Technological advances towards extracellular vesicles mass production60
Dawn of lipid nanoparticles in lymph node targeting: Potential in cancer immunotherapy60
Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems59
Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy58
Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic58
Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery58
The effects of protein corona on in vivo fate of nanocarriers58
Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis58
Vaccine delivery systems toward lymph nodes58
Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders57
Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection57
Mesoporous silica nanoparticles for pulmonary drug delivery57
Delivery of STING agonists for adjuvanting subunit vaccines57
Imaging technology of the lymphatic system57
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives56
An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers56
Why nanoparticles prefer liver macrophage cell uptake in vivo56
Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years56
Scaled preparation of extracellular vesicles from conditioned media56
Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms55
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across55
Separation, characterization, and standardization of extracellular vesicles for drug delivery applications55
Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential54
Tumor-on-chip modeling of organ-specific cancer and metastasis54
α-Amino acid N-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery54
In situ activation of therapeutics through bioorthogonal catalysis54
Biomembrane-based nanostructures for cancer targeting and therapy: From synthetic liposomes to natural biomembranes and membrane-vesicles54
Metal-organic frameworks for therapeutic gas delivery53
2D materials-based nanomedicine: From discovery to applications53
Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms53
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine52
Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design51
Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants51
Cell-penetrating peptides in protein mimicry and cancer therapeutics51
Nanomedicine for brain cancer51
A quantitative view on multivalent nanomedicine targeting50
Dry powder pharmaceutical biologics for inhalation therapy50
Tumor microenvironment-responsive dynamic inorganic nanoassemblies for cancer imaging and treatment50
High-throughput proteomics and AI for cancer biomarker discovery49
In silico T cell epitope identification for SARS-CoV-2: Progress and perspectives49
Advances in mRNA non-viral delivery approaches49
Engineering interferons and interleukins for cancer immunotherapy49
Clinical translation of advanced colonic drug delivery technologies48
Stabilizers and their interaction with formulation components in frozen and freeze-dried protein formulations48
The in vivo fate of polymeric micelles47
Nucleic acid delivery with extracellular vesicles47
Self-assembly of protein-polymer conjugates for drug delivery47
Responsive optical probes for deep-tissue imaging: Photoacoustics and second near-infrared fluorescence47
Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma46
Smart gating porous particles as new carriers for drug delivery46
Extracellular vesicles as antigen carriers for novel vaccination avenues46
Pharmaceutical applications of powder-based binder jet 3D printing process – A review46
Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)45
Automation and data-driven design of polymer therapeutics45
Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models45
Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach45
Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities44
Defensins: The natural peptide antibiotic44
Synthetic multi-layer nanoparticles for CRISPR-Cas9 genome editing44
Microarray patches enable the development of skin-targeted vaccines against COVID-1943
Emerging strategies in developing multifunctional nanomaterials for cancer nanotheranostics43
Bacterial extracellular vesicles: Understanding biology promotes applications as nanopharmaceuticals43
Electroactive material-based biosensors for detection and drug delivery43
Novel antimicrobial agents for combating antibiotic-resistant bacteria43
Bioinspired drug delivery strategies for repurposing conventional antibiotics against intracellular infections42
Autophagy in the cancer-immunity dialogue42
Advances and future perspectives in epithelial drug delivery42
Stability of lyophilized and spray dried vaccine formulations42
Modulating the foreign body response of implants for diabetes treatment42
Nanotechnology-empowered vaccine delivery for enhancing CD8+ T cells-mediated cellular immunity42
Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe42
Integration of personalized drug delivery systems into digital health41
The promising interplay between sonodynamic therapy and nanomedicine41
Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers41
Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract41
Building three-dimensional lung models for studying pharmacokinetics of inhaled drugs40
Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors40
A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing40
Rationally designed drug delivery systems for the local treatment of resected glioblastoma40
Extracellular vesicles as delivery systems at nano-/micro-scale40
Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs – EVOLVE France”40
Gene- and RNAi-activated scaffolds for bone tissue engineering: Current progress and future directions40
Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches – An overview39
Advancing pharmacy and healthcare with virtual digital technologies39
Development and aging of the lymphatic vascular system39
Nano-delivery to the lung - by inhalation or other routes and why nano when micro is largely sufficient?39
Mastering the Gram-negative bacterial barrier – Chemical approaches to increase bacterial bioavailability of antibiotics39
Listening to drug delivery and responses via photoacoustic imaging39
Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages39
Engineering of stimuli-responsive self-assembled biomimetic nanoparticles38
Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome38
Formulation strategies to improve the efficacy of intestinal permeation enhancers,38
Extracellular vesicles for the treatment of central nervous system diseases38
Supercritical fluid (SCF)-assisted fabrication of carrier-free drugs: An eco-friendly welcome to active pharmaceutical ingredients (APIs)38
Nucleic acid nanoparticles (NANPs) as molecular tools to direct desirable and avoid undesirable immunological effects37
Adherence to minimal experimental requirements for defining extracellular vesicles and their functions37
Artificial intelligence to bring nanomedicine to life37
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound37
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy36
Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines36
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders36
Organ-on-a-chip technology for the study of the female reproductive system36
Ferritin nanocage: A promising and designable multi-module platform for constructing dynamic nanoassembly-based drug nanocarrier36
Biomaterial-based delivery of nucleic acids for tissue regeneration35
Delivering more for less: nanosized, minimal-carrier and pharmacoactive drug delivery systems35
GO-based antibacterial composites: Application and design strategies35
Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing35
The RNA-binding protein HuR in human cancer: A friend or foe?35
Nanovaccines with cell-derived components for cancer immunotherapy35
Understanding molecular mechanisms of biologics drug delivery and stability from NMR spectroscopy35
Two-Dimensional Nanomaterial-based catalytic Medicine: Theories, advanced catalyst and system design35
Antifibrotic strategies for medical devices35
Harnessing cerebrospinal fluid circulation for drug delivery to brain tissues35
The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis35
Biomimetic immunomodulation strategies for effective tissue repair and restoration35
Dynamic nanoassemblies of nanomaterials for cancer photomedicine35
Human skin equivalents: Impaired barrier function in relation to the lipid and protein properties of the stratum corneum35
Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments35
Coiled coil-based therapeutics and drug delivery systems34
Mucosal drug delivery and 3D printing technologies: A focus on special patient populations34
Antimicrobial blue light: A ‘Magic Bullet’ for the 21st century and beyond?34
Bacterial membrane vesicles for vaccine applications33
Sustained delivery approaches to improving adaptive immune responses33
In vitro and ex vivo models in inhalation biopharmaceutical research — advances, challenges and future perspectives33
Merging data curation and machine learning to improve nanomedicines33
Inhalation delivery technology for genome-editing of respiratory diseases33
Role of extracellular vesicles in liver diseases and their therapeutic potential33
Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems32
Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems32
Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives32
Particle engineering principles and technologies for pharmaceutical biologics32
Drug release from in situ forming implants and advances in release testing32
Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery32
Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics32
Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors32
Engineering and loading therapeutic extracellular vesicles for clinical translation: A data reporting frame for comparability32
Self-assembling peptides as vectors for local drug delivery and tissue engineering applications32
Pharmaceutical protein solids: Drying technology, solid-state characterization and stability31
Polymers in pharmaceutical additive manufacturing: A balancing act between printability and product performance31
Non-viral nanoparticles for RNA interference: Principles of design and practical guidelines31
Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy31
Non-viral strategies for delivering genome editing enzymes31
Destruction of tumor vasculature by vascular disrupting agents in overcoming the limitation of EPR effect31
Controlling drug release with additive manufacturing-based solutions30
Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models30
Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment30
Natural killer (NK) cell-based immunotherapies and the many faces of NK cell memory: A look into how nanoparticles enhance NK cell activity30
Stealth and pseudo-stealth nanocarriers30
Targeting the tumor biophysical microenvironment to reduce resistance to immunotherapy30
Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges30
Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development?30
Versatility on demand – The case for semi-solid micro-extrusion in pharmaceutics30
The in vivo fate and targeting engineering of crossover vesicle-based gene delivery system30