Advanced Drug Delivery Reviews

Article	Citations
Cell membrane-coated nanoparticles for targeting carcinogenic bacteria	719
Editorial board members	382
Penetration and translocation of functional inorganic nanomaterials into biological barriers	300
Emerging antibiotic alternatives: From antimicrobial peptides to bacteriophage therapies	300
Long-acting inhaled medicines: Present and future	299
Gene editing strategies to treat lysosomal disorders: The example of mucopolysaccharidoses	288
Nanoparticle-neutrophils interactions for autoimmune regulation	261
MIDD in Japan– Implementations, challenges and opportunities	246
Genome-scale metabolic modelling in antimicrobial pharmacology: Present and future	245
Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art	236
Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders	195
Liposomal formulations for treating lysosomal storage disorders	193
Leveraging the neurosurgical operating room for therapeutic development in NeuroOncology	193
Therapeutic and delivery strategies of phytoconstituents for renal fibrosis	177
Deciphering albumin-directed drug delivery by imaging	172
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine	165
Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity	158
Recent advances in endocrine organoids for therapeutic application	153
Nanovaccines with cell-derived components for cancer immunotherapy	151
Tools for computational design and high-throughput screening of therapeutic enzymes	147
MicroRNAs and their delivery in diabetic fibrosis	146
Drug delivery for metabolism targeted cancer immunotherapy	144
Bacterially mediated drug delivery and therapeutics: Strategies and advancements	143
Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound	142
Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond	137

Drug delivery strategies in maximizing anti-angiogenesis and anti-tumor immunity	134
Models to study basic and applied aspects of lysosomal storage disorders	133
Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies	133
Emerging Voices in Drug Delivery – Harnessing and Modulating Complex Biological Systems (Issue 2)	132
Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles	132
From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly	131
3D printing of drug delivery systems enhanced with micro/nano-technology	131
Editorial Board	131
Editorial/Preface	130
Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics	129
Strategies to develop polymeric microneedles for controlled drug release	127
Novel strategies for modulating the gut microbiome for cancer therapy	123
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer’s disease	122
Activatable dual-functional molecular agents for imaging-guided cancer therapy	119
Solid implantable devices for sustained drug delivery	119
In situ cellular hitchhiking of nanoparticles for drug delivery	118
RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer	117
Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery	116
In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols	115
Synthetic biology-guided design and biosynthesis of protein polymers for delivery	113
Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications	112
Targeting microbiome, drug metabolism, and drug delivery in oncology	112
Activatable fluorescent probes for real-time imaging-guided tumor therapy	111
Exosome- and extracellular vesicle-based approaches for the treatment of lysosomal storage disorders	110
Ultrasonic particles: An approach for targeted gene delivery	109
Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers	108
Drug delivery using gold nanoparticles	108
Biopharmaceutical drug delivery and phototherapy using protein crystals	105
Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches	105
Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos	100
Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers	100
Unignored intracellular journey and biomedical applications of extracellular vesicles	99
Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases	99
Technological and translational challenges for extracellular vesicle in therapy and diagnosis	99
Nanosensitizer-mediated unique dynamic therapy tactics for effective inhibition of deep tumors	98
Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies	98
Hurdles in translating science from lab to market in delivery systems for Cosmetics: An industrial perspective	98
Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system	97
Tumour extravasation of nanomedicine: The EPR and alternative pathways	95
Novel drug delivery systems for the management of dry eye	95
Micro-patterned cell populations as advanced pharmaceutical drugs with precise functional control	94
Convection-enhanced delivery for brain malignancies: Technical parameters, formulation strategies and clinical perspectives	94
Lysosomal therapies and drug delivery strategies: An overview	93
Engineering bacterial membrane nanovesicles for improved therapies in infectious diseases and cancer	92
Soft nano and microstructures for the photomodulation of cellular signaling and behavior	92
In-vitro 3D modelling for charged particle therapy – Uncertainties and opportunities	91
The extracellular matrix of hematopoietic stem cell niches	90
Model-informed precision dosing: State of the art and future perspectives	90
Modular design principle based on compartmental drug delivery systems	90
Nanobodies: Robust miniprotein binders in biomedicine	89

Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers	88
To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives	88
Drug delivery strategies for management of women’s health issues in the upper genital tract	88
Fit and forget: The future of dental implant therapy via nanotechnology	88
Advances in photoactivated carbon-based nanostructured materials for targeted cancer therapy	87
Preface: Image-assisted organoid research and application	86
Corrigendum to “Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration” [Adv. Drug Deliv. Rev. 209 (2024) 115328]	86
Engineering complexity in human tissue models of cancer	86
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease	85
Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications	85
Editorial Board	85
Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy	84
Editorial board members	84
Editorial board members	83
Editorial board members	83
Recent progress in upconversion nanomaterials for emerging optical biological applications	82
Engineering and loading therapeutic extracellular vesicles for clinical translation: A data reporting frame for comparability	82
Trends and patterns in cancer nanotechnology research: A survey of NCI's caNanoLab and nanotechnology characterization laboratory	81
Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery	81
Nanoparticles for local delivery of siRNA in lung therapy	80
Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers	79
Listening to drug delivery and responses via photoacoustic imaging	79
Responsive nanomedicines enhanced by or enhancing physical modalities to treat solid cancer tumors: Preclinical and clinical evidence of safety and efficacy	79
Corrigendum to ‘Cell-penetrating peptides in protein mimicry and cancer therapeutics’ [Advanced Drug Delivery Reviews, 180 (2022), 114044]	78
Nanomedicine from amphiphilized prodrugs: Concept and clinical translation	78
Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment	77
Modulating tumor physical microenvironment for fueling CAR-T cell therapy	77
Nanoparticle-based immunotherapeutics: From the properties of nanocores to the differential effects of administration routes	77
MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration	77
Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy	77
Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness	76
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders	76
Design of disintegrable nanoassemblies to release multiple small-sized nanoparticles	76
Additive manufacturing in spatial patterning for spinal cord injury treatment	75
Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models	75
Patient-Derived 3D-Bioprinted Models of Pancreatic Cancer: Toward Personalized Therapy and Overcoming Tumor Microenvironment Challenges	75
Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19	74
Progress of engineered bacteria for tumor therapy	74
mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond	74
Blood-brain barrier delivery for lysosomal storage disorders with IgG-lysosomal enzyme fusion proteins	74
Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery	74
Omics approaches for the assessment of biological responses to nanoparticles	73
Editorial Board	73
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound	73
Clinical translation of advanced colonic drug delivery technologies	73
Applications of pharmacometrics in drug development	73
Spectral computed tomography with inorganic nanomaterials: State-of-the-art	73
Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo	73
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook	73
Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance	72
Cell-penetrating peptides in protein mimicry and cancer therapeutics	72
Advances in Salmonella Typhimurium-based drug delivery system for cancer therapy	72
Imaging drug delivery to the lungs: Methods and applications in oncology	71
Local scaffold-assisted delivery of immunotherapeutic agents for improved cancer immunotherapy	71
Engineering of stimuli-responsive self-assembled biomimetic nanoparticles	70
Get out or die trying: Peptide- and protein-based endosomal escape of RNA therapeutics	70
Nanoarchitectured two-dimensional layered double hydroxides-based nanocomposites for biomedical applications	69
Intrathecal delivery and its applications in leptomeningeal disease	69
Synthetic polypeptides for drug and gene delivery, and tissue engineering	69
Steric stabilization of bioactive nanoparticles using elastin-like polypeptides	68
Recent developments in lactose blend formulations for carrier-based dry powder inhalation	68
Microbiota and plant-derived vesicles that serve as therapeutic agents and delivery carriers to regulate metabolic syndrome	67
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives	67
Of devices and drugs – Ingestible bots for diagnosis and therapy	67
Dynamic nano-assemblies based on two-dimensional inorganic nanoparticles: Construction and preclinical demonstration	67
Corrigendum to “Advanced theragnostics for the central nervous system (CNS) and neurological disorders using functional inorganic nanomaterials” [Adv. Drug Delivery Rev. 192 (2023) 114636]	67
3D extrusion bioprinting of microbial inks for biomedical applications	67
Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery	66
Nanomedicine for targeting brain Neurodegeneration: Critical barriers and circadian rhythm Considerations	66
The dynamic, motile and deformative properties of RNA nanoparticles facilitate the third milestone of drug development	66
Corrigendum to “Light sheet fluorescence microscopy for monitoring drug delivery: unlocking the developmental phases of embryos” [Adv Drug Del. Rev. 218 (2025) 115520]	66
Laser ablation: Heating up the anti-tumor response in the intracranial compartment	65
Progress of tumor-resident intracellular bacteria for cancer therapy	65
Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors – An update	64
Editorial board members	64
Special Issue (SI) on: Emerging pharmaceutical technologies (From advanced materials & formulations to new processes) for novel dosage development	64
Pancreatic organoids as cancer avatars for true personalized medicine	64
Sustained delivery approaches to improving adaptive immune responses	63
Microneedle-Mediated Vaccination: Innovation and Translation	63
Ocular therapies with biomacromolecules: From local injection to eyedrop and emerging noninvasive delivery strategies	63

Delivery of synthetic mRNAs for tissue regeneration	63
Towards artificial intelligence-enabled extracellular vesicle precision drug delivery	61
The tendon microenvironment: Engineered in vitro models to study cellular crosstalk	61
Microbubble-assisted ultrasound for inner ear drug delivery	60
Revealing the clinical potential of high-resolution organoids	60
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics	60
Corrigendum to “Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic” [Adv. Drug Delivery Rev. 179 (2021) 114000]	59
Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment	59
Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years	59
Merging data curation and machine learning to improve nanomedicines	58
Integrated pharmacokinetic-pharmacodynamic and agent-based modelling in drug development: Current status and future perspectives	57
Next generation concepts in dermal delivery, theranostics, and preclinical testing	57
Biosafety of mesoporous silica nanoparticles; towards clinical translation	57
Editorial Board	57
Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment	56
Theme issue: In vitro mucus models	56
Transdermal drug delivery via microneedles to mediate wound microenvironment	56
Recent applications of three-dimensional bioprinting in drug discovery and development	56
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health	56
Cell-based relay delivery strategy in biomedical applications	56
Editorial Board	56
Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling	56
Editorial board members	56
Precise subcellular targeting approaches for organelle-related disorders	56
Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria	56
Targeted delivery methods for RNA interference are necessary to obtain a potential functional cure for HIV/AIDS	55
Editorial board members	55
Editorial board members	55
Fungal infections: Immune defense, immunotherapies and vaccines	54
Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic	54
Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids	54
Current issues in optical monitoring of drug delivery via hair follicles	54
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics	54
The RNA-binding protein HuR in human cancer: A friend or foe?	54
Drugging the lymphatic system: An emerging opportunity for cancer immunotherapy	54
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation	54
Advances in modular control of CAR-T therapy with adapter-mediated CARs	54
Leveraging advances in immunopathology and artificial intelligence to analyze in vitro tumor models in composition and space	54
Synthetic RNA-based post-transcriptional expression control methods and genetic circuits	53
Editorial board members	53
Long-acting parenteral drug delivery systems for the treatment of chronic diseases	53
Photonic and magnetic materials for on-demand local drug delivery	52
Biomedical engineering of two-dimensional MXenes	52
Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor	52
The effects of protein corona on in vivo fate of nanocarriers	52
Mesoporous silica nanoparticles for pulmonary drug delivery	51
Stealth and pseudo-stealth nanocarriers	51
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems	51
Editorial Board	50
Polymeric in situ forming depots for long-acting drug delivery systems	50
Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery	50
Therapeutic approaches targeting molecular signaling pathways common to diabetes, lung diseases and cancer	50
Interaction of 2D nanomaterial with cellular barrier: Membrane attachment and intracellular trafficking	50
Advances in mRNA therapeutics for cancer immunotherapy: From modification to delivery	50
Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease	50
Advanced delivery systems for peptide antibiotics	50
Purified mucins in drug delivery research	50
Bioengineering toolkits for potentiating organoid therapeutics	50
From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer	50