Advanced Drug Delivery Reviews

Article	Citations
Leveraging the neurosurgical operating room for therapeutic development in NeuroOncology	676
Editorial board members	611
Drug delivery for metabolism targeted cancer immunotherapy	370
Deciphering albumin-directed drug delivery by imaging	292
MIDD in Japan– Implementations, challenges and opportunities	289
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine	282
Gene editing strategies to treat lysosomal disorders: The example of mucopolysaccharidoses	280
Penetration and translocation of functional inorganic nanomaterials into biological barriers	244
Liposomal formulations for treating lysosomal storage disorders	241
Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art	240
Nanoparticle-neutrophils interactions for autoimmune regulation	232
MicroRNAs and their delivery in diabetic fibrosis	228
Cell membrane-coated nanoparticles for targeting carcinogenic bacteria	189
Tools for computational design and high-throughput screening of therapeutic enzymes	186
Drug delivery strategies in maximizing anti-angiogenesis and anti-tumor immunity	186
Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders	186
Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond	170
Emerging antibiotic alternatives: From antimicrobial peptides to bacteriophage therapies	164
Therapeutic and delivery strategies of phytoconstituents for renal fibrosis	161
Recent advances in endocrine organoids for therapeutic application	153
Models to study basic and applied aspects of lysosomal storage disorders	149
Long-acting inhaled medicines: Present and future	141
Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound	141
Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles	141
Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity	139

Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies	137
Nanovaccines with cell-derived components for cancer immunotherapy	136
Biopharmaceutical drug delivery and phototherapy using protein crystals	133
Bacterially mediated drug delivery and therapeutics: Strategies and advancements	133
Editorial/Preface	131
Targeting microbiome, drug metabolism, and drug delivery in oncology	129
Emerging Voices in Drug Delivery – Harnessing and Modulating Complex Biological Systems (Issue 2)	129
From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly	128
Activatable dual-functional molecular agents for imaging-guided cancer therapy	127
Phytonanomaterials as therapeutic agents and drug delivery carriers	126
In situ cellular hitchhiking of nanoparticles for drug delivery	125
Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers	125
Novel strategies for modulating the gut microbiome for cancer therapy	124
Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications	124
Solid implantable devices for sustained drug delivery	123
Editorial Board	123
In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols	123
Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics	119
3D printing of drug delivery systems enhanced with micro/nano-technology	118
Ultrasonic particles: An approach for targeted gene delivery	115
Exosome- and extracellular vesicle-based approaches for the treatment of lysosomal storage disorders	114
Activatable fluorescent probes for real-time imaging-guided tumor therapy	114
RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer	113
Synthetic biology-guided design and biosynthesis of protein polymers for delivery	112
Drug delivery using gold nanoparticles	111
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer’s disease	111
Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases	111
Strategies to develop polymeric microneedles for controlled drug release	111
Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems	111
Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches	110
Lysosomal therapies and drug delivery strategies: An overview	109
Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery	109
Drug delivery strategies for management of women’s health issues in the upper genital tract	106
Micro-patterned cell populations as advanced pharmaceutical drugs with precise functional control	106
Technological and translational challenges for extracellular vesicle in therapy and diagnosis	105
In-vitro 3D modelling for charged particle therapy – Uncertainties and opportunities	104
Soft nano and microstructures for the photomodulation of cellular signaling and behavior	104
Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases	103
Tumour extravasation of nanomedicine: The EPR and alternative pathways	98
Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos	98
Engineering complexity in human tissue models of cancer	98
Hurdles in translating science from lab to market in delivery systems for Cosmetics: An industrial perspective	97
Modular design principle based on compartmental drug delivery systems	97
Convection-enhanced delivery for brain malignancies: Technical parameters, formulation strategies and clinical perspectives	96
Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies	96
Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers	94
Advances in photoactivated carbon-based nanostructured materials for targeted cancer therapy	93
Nanosensitizer-mediated unique dynamic therapy tactics for effective inhibition of deep tumors	93
Engineering bacterial membrane nanovesicles for improved therapies in infectious diseases and cancer	92
High-throughput proteomics and AI for cancer biomarker discovery	91

Novel drug delivery systems for the management of dry eye	91
Model-informed precision dosing: State of the art and future perspectives	90
Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system	90
To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives	89
Nanobodies: Robust miniprotein binders in biomedicine	89
Unignored intracellular journey and biomedical applications of extracellular vesicles	88
The extracellular matrix of hematopoietic stem cell niches	88
Fit and forget: The future of dental implant therapy via nanotechnology	87
Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers	87
Preface: Image-assisted organoid research and application	86
Editorial board members	86
Corrigendum to “Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration” [Adv. Drug Deliv. Rev. 209 (2024) 115328]	86
Corrigendum to ‘Cell-penetrating peptides in protein mimicry and cancer therapeutics’ [Advanced Drug Delivery Reviews, 180 (2022), 114044]	86
Editorial board members	86
Editorial board members	86
Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers	85
Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery	84
Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment	84
Responsive nanomedicines enhanced by or enhancing physical modalities to treat solid cancer tumors: Preclinical and clinical evidence of safety and efficacy	84
Nanomedicine from amphiphilized prodrugs: Concept and clinical translation	84
Women-specific routes of administration for drugs: A critical overview	83
Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications	83
Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)	83
Trends and patterns in cancer nanotechnology research: A survey of NCI's caNanoLab and nanotechnology characterization laboratory	81
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders	81
Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy	81
Engineering and loading therapeutic extracellular vesicles for clinical translation: A data reporting frame for comparability	81
Aptamer-based targeted drug delivery and disease therapy in preclinical and clinical applications	80
Nanoparticles for local delivery of siRNA in lung therapy	80
Recent progress in upconversion nanomaterials for emerging optical biological applications	79
Modulating tumor physical microenvironment for fueling CAR-T cell therapy	79
Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy	79
Design of disintegrable nanoassemblies to release multiple small-sized nanoparticles	78
MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration	78
Listening to drug delivery and responses via photoacoustic imaging	78
Nanoparticle-based immunotherapeutics: From the properties of nanocores to the differential effects of administration routes	77
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease	77
Design principles for construction of DNA-based nanostructures	76
Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models	76
Spectral computed tomography with inorganic nanomaterials: State-of-the-art	75
Additive manufacturing in spatial patterning for spinal cord injury treatment	75
Blood-brain barrier delivery for lysosomal storage disorders with IgG-lysosomal enzyme fusion proteins	75
Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness	75
Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19	75
Drug delivery, development, and technological aspects for peripheral drug eluting stents	74
mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond	74
Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery	74
Omics approaches for the assessment of biological responses to nanoparticles	73
Clinical translation of advanced colonic drug delivery technologies	73
Progress of engineered bacteria for tumor therapy	73
Local scaffold-assisted delivery of immunotherapeutic agents for improved cancer immunotherapy	72
Corrigendum to “Advanced theragnostics for the central nervous system (CNS) and neurological disorders using functional inorganic nanomaterials” [Adv. Drug Delivery Rev. 192 (2023) 114636]	72
Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance	72
Editorial Board	72
Of devices and drugs – Ingestible bots for diagnosis and therapy	72
Synthetic polypeptides for drug and gene delivery, and tissue engineering	71
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook	71
Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics	71
Recent developments in lactose blend formulations for carrier-based dry powder inhalation	71
Intrathecal delivery and its applications in leptomeningeal disease	70
3D extrusion bioprinting of microbial inks for biomedical applications	70
Adherence to minimal experimental requirements for defining extracellular vesicles and their functions	69
Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo	69
Get out or die trying: Peptide- and protein-based endosomal escape of RNA therapeutics	68
Engineering of stimuli-responsive self-assembled biomimetic nanoparticles	68
Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery	68
Imaging drug delivery to the lungs: Methods and applications in oncology	68
The dynamic, motile and deformative properties of RNA nanoparticles facilitate the third milestone of drug development	68
Microbiota and plant-derived vesicles that serve as therapeutic agents and delivery carriers to regulate metabolic syndrome	68
Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment	67
Advances in Salmonella Typhimurium-based drug delivery system for cancer therapy	66
Dynamic nano-assemblies based on two-dimensional inorganic nanoparticles: Construction and preclinical demonstration	66
Cell-penetrating peptides in protein mimicry and cancer therapeutics	66
Applications of pharmacometrics in drug development	66
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound	65
Steric stabilization of bioactive nanoparticles using elastin-like polypeptides	65
Nanomedicine for targeting brain Neurodegeneration: Critical barriers and circadian rhythm Considerations	64
Editorial board members	64
The tendon microenvironment: Engineered in vitro models to study cellular crosstalk	64
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives	64

Special Issue (SI) on: Emerging pharmaceutical technologies (From advanced materials & formulations to new processes) for novel dosage development	64
Nanoarchitectured two-dimensional layered double hydroxides-based nanocomposites for biomedical applications	64
Delivery of synthetic mRNAs for tissue regeneration	63
Progress of tumor-resident intracellular bacteria for cancer therapy	63
Ocular therapies with biomacromolecules: From local injection to eyedrop and emerging noninvasive delivery strategies	63
Corrigendum to “Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic” [Adv. Drug Delivery Rev. 179 (2021) 114000]	63
Corrigendum to “Light sheet fluorescence microscopy for monitoring drug delivery: unlocking the developmental phases of embryos” [Adv Drug Del. Rev. 218 (2025) 115520]	62
Biomaterial-based delivery of nucleic acids for tissue regeneration	62
Revealing the clinical potential of high-resolution organoids	62
Microbubble-assisted ultrasound for inner ear drug delivery	61
Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment	61
Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years	61
Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors – An update	60
Pancreatic organoids as cancer avatars for true personalized medicine	60
Merging data curation and machine learning to improve nanomedicines	60
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics	60
Towards artificial intelligence-enabled extracellular vesicle precision drug delivery	59
Laser ablation: Heating up the anti-tumor response in the intracranial compartment	59
Sustained delivery approaches to improving adaptive immune responses	59
Biosafety of mesoporous silica nanoparticles; towards clinical translation	58
Microneedle-Mediated Vaccination: Innovation and Translation	58
Editorial board members	57
Editorial board members	57
Editorial board members	57
Editorial board members	57
Editorial board members	57
Editorial Board	56
Integrated pharmacokinetic-pharmacodynamic and agent-based modelling in drug development: Current status and future perspectives	56
Next generation concepts in dermal delivery, theranostics, and preclinical testing	56
Drugging the lymphatic system: An emerging opportunity for cancer immunotherapy	55
Editorial Board	55
Theme issue: In vitro mucus models	55
Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic	54
From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer	54
Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria	54
Leveraging advances in immunopathology and artificial intelligence to analyze in vitro tumor models in composition and space	54
Synthetic RNA-based post-transcriptional expression control methods and genetic circuits	54
Advances in long-acting injectables, implants, and vaginal rings for contraception and HIV prevention	54
Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment	53
Recent applications of three-dimensional bioprinting in drug discovery and development	53
Transdermal drug delivery via microneedles to mediate wound microenvironment	53
Precise subcellular targeting approaches for organelle-related disorders	53
Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor	53
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems	53
Fungal infections: Immune defense, immunotherapies and vaccines	53
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation	52
Advances in modular control of CAR-T therapy with adapter-mediated CARs	52
Targeted delivery methods for RNA interference are necessary to obtain a potential functional cure for HIV/AIDS	52
Cell-based relay delivery strategy in biomedical applications	52
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health	52
Biomedical engineering of two-dimensional MXenes	52
Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids	52
Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling	52
The RNA-binding protein HuR in human cancer: A friend or foe?	51
The effects of protein corona on in vivo fate of nanocarriers	51
The role of the HBCU pipeline in diversifying the STEM workforce: Training the next generation of drug delivery researchers	51
Current issues in optical monitoring of drug delivery via hair follicles	51
Stealth and pseudo-stealth nanocarriers	51
Mesoporous silica nanoparticles for pulmonary drug delivery	50
Photonic and magnetic materials for on-demand local drug delivery	50
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics	50
Polymeric in situ forming depots for long-acting drug delivery systems	49
Nanomedicine for brain cancer	49
Imaging and therapeutic targeting of the tumor immune microenvironment with biologics	49
Translating a radiolabeled imaging agent to the clinic	49
Defensins: The natural peptide antibiotic	49
Bioengineering toolkits for potentiating organoid therapeutics	49
Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap	49
Editorial Board	49
Advanced delivery systems for peptide antibiotics	49
Gene editing therapeutics based on mRNA delivery	49
Long-acting parenteral drug delivery systems for the treatment of chronic diseases	49
Interaction of 2D nanomaterial with cellular barrier: Membrane attachment and intracellular trafficking	49