Advanced Drug Delivery Reviews

Article	Citations
Editorial board members	998
Emerging antibiotic alternatives: From antimicrobial peptides to bacteriophage therapies	357
Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound	306
Liposomal formulations for treating lysosomal storage disorders	269
Gene editing strategies to treat lysosomal disorders: The example of mucopolysaccharidoses	242
MIDD in Japan– Implementations, challenges and opportunities	229
Models to study basic and applied aspects of lysosomal storage disorders	227
Penetration and translocation of functional inorganic nanomaterials into biological barriers	218
Leveraging the neurosurgical operating room for therapeutic development in NeuroOncology	218
Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles	214
Bacterially mediated drug delivery and therapeutics: Strategies and advancements	214
Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art	198
Covalent chemistry in targeted protein degradation	196
On-Chip modeling of drug-gut interactions in Oral drug delivery	195
Recent advances in endocrine organoids for therapeutic application	193
Genome-scale metabolic modelling in antimicrobial pharmacology: Present and future	191
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine	183
Deciphering albumin-directed drug delivery by imaging	179
Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders	174
In vitro models of the interplay between glioblastoma and blood–brain barrier for stratifying drug efficacy	170
Long-acting inhaled medicines: Present and future	169
Cell membrane-coated nanoparticles for targeting carcinogenic bacteria	165
Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond	160
Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity	159
Nanoparticle-neutrophils interactions for autoimmune regulation	150

Protein-based nanocarriers in the management of hard-to-treat solid tumours	149
Editorial Board	147
From molecule to absorption: a multiscale framework for subcutaneous biologic delivery	141
Editorial Board	140
Targeting microbiome, drug metabolism, and drug delivery in oncology	139
Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics	139
Editorial/Preface	137
Emerging Voices in Drug Delivery – Harnessing and Modulating Complex Biological Systems (Issue 2)	135
iPSC-derived T cells and macrophages: Manufacturing and next-generation application approaches	134
RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer	132
Exosome- and extracellular vesicle-based approaches for the treatment of lysosomal storage disorders	124
Hydrogen sulfide in cancer therapy: Intelligent delivery platforms and synergistic therapeutic paradigms	123
Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications	119
Activatable fluorescent probes for real-time imaging-guided tumor therapy	119
3D printing of drug delivery systems enhanced with micro/nano-technology	119
Novel strategies for modulating the gut microbiome for cancer therapy	118
In situ cellular hitchhiking of nanoparticles for drug delivery	117
Strategies to develop polymeric microneedles for controlled drug release	116
Red to near-infrared carbon dots: synthesis, cellular interactions, drug loading, and therapeutic applications	116
Biopharmaceutical drug delivery and phototherapy using protein crystals	111
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer’s disease	110
Synthetic biology-guided design and biosynthesis of protein polymers for delivery	109
From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly	108
Quality by Computational Design: Harnessing AI to Advance Rational Drug Development	107
Small data, big challenges: Machine- and deep-learning strategies for data-limited drug discovery	107
Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches	106
Drug delivery using gold nanoparticles	105
Solid implantable devices for sustained drug delivery	104
Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases	103
Activatable dual-functional molecular agents for imaging-guided cancer therapy	103
Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system	102
Unignored intracellular journey and biomedical applications of extracellular vesicles	102
Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers	101
Technology for Nucleic Acid Delivery in the Treatment of Hematological Malignancies	99
Lysosomal therapies and drug delivery strategies: An overview	99
Engineering bacterial membrane nanovesicles for improved therapies in infectious diseases and cancer	98
Hurdles in translating science from lab to market in delivery systems for Cosmetics: An industrial perspective	98
Nanosensitizer-mediated unique dynamic therapy tactics for effective inhibition of deep tumors	97
Tumour extravasation of nanomedicine: The EPR and alternative pathways	97
Therapeutic gases as emerging treatments for oral diseases	96
Novel drug delivery systems for the management of dry eye	95
Soft nano and microstructures for the photomodulation of cellular signaling and behavior	93
Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos	93
Tumor microenvironment subtyping in pancreatic ductal adenocarcinoma: New avenues for personalized therapeutic strategies	93
Fit and forget: The future of dental implant therapy via nanotechnology	92
Convection-enhanced delivery for brain malignancies: Technical parameters, formulation strategies and clinical perspectives	92
Advances in photoactivated carbon-based nanostructured materials for targeted cancer therapy	92
Matrix-integrated microfluidic tumor models for evaluating drug delivery systems and pre-clinical testing	91
Nanobodies: Robust miniprotein binders in biomedicine	91
Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers	90

Model-informed precision dosing: State of the art and future perspectives	90
Preface: Image-assisted organoid research and application	89
Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies	89
Harnessing reactive oxygen species for precision medicine: ROS-Activatable PROTACs for lung Cancer	88
Editorial Board	88
Corrigendum to “Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration” [Adv. Drug Deliv. Rev. 209 (2024) 115328]	88
MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration	88
Editorial board members	88
Engineering tissue patterning in human stem cell-based embryo models	87
Design principles for construction of DNA-based nanostructures	87
Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers	86
Rational modification of PROTACs for tumor-selective protein degradation	86
Nanoparticle-based immunotherapeutics: From the properties of nanocores to the differential effects of administration routes	85
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease	85
Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications	84
Recent progress in upconversion nanomaterials for emerging optical biological applications	84
Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy	83
Trends and patterns in cancer nanotechnology research: A survey of NCI's caNanoLab and nanotechnology characterization laboratory	83
Design of disintegrable nanoassemblies to release multiple small-sized nanoparticles	83
Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy	82
Modulating tumor physical microenvironment for fueling CAR-T cell therapy	80
Aptamer-based targeted drug delivery and disease therapy in preclinical and clinical applications	80
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders	79
Editorial Board	79
Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment	79
Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness	78
Investigating the restriction-modification barrier to DNA delivery in human gut probiotic bacteria for streamlined genetic tool development	78
Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models	78
Medicinal gases for treating central nervous system injuries	78
Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery	77
Drug delivery, development, and technological aspects for peripheral drug eluting stents	77
Additive manufacturing in spatial patterning for spinal cord injury treatment	75
From canes to pills: the evolution of carbon monoxide therapeutics	74
Progress of engineered bacteria for tumor therapy	74
Microbial heterogeneity-mediated treatment evasion and the potential for engineered live biotherapeutic products	74
Spectral computed tomography with inorganic nanomaterials: State-of-the-art	73
Omics approaches for the assessment of biological responses to nanoparticles	73
Integrating PROTAC-based targeted protein degradation with nanodelivery systems to overcome cancer therapeutic resistance	73
Recent advances in intelligent oxygen delivery systems for tissue regeneration	73
mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond	72
Patient-Derived 3D-Bioprinted Models of Pancreatic Cancer: Toward Personalized Therapy and Overcoming Tumor Microenvironment Challenges	72
Editorial Board	71
Corrigendum to “Advanced theragnostics for the central nervous system (CNS) and neurological disorders using functional inorganic nanomaterials” [Adv. Drug Delivery Rev. 192 (2023) 114636]	70
3D extrusion bioprinting of microbial inks for biomedical applications	69
Editorial Board	69
Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo	69
Intrathecal delivery and its applications in leptomeningeal disease	69
Steric stabilization of bioactive nanoparticles using elastin-like polypeptides	68
Nitric oxide-modulating biomaterials for therapeutic Immunoengineering	67
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook	67
Applications of pharmacometrics in drug development	67
Advances in Salmonella Typhimurium-based drug delivery system for cancer therapy	66
Microbiota and plant-derived vesicles that serve as therapeutic agents and delivery carriers to regulate metabolic syndrome	65
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives	65
Imaging drug delivery to the lungs: Methods and applications in oncology	64
Get out or die trying: Peptide- and protein-based endosomal escape of RNA therapeutics	64
Local scaffold-assisted delivery of immunotherapeutic agents for improved cancer immunotherapy	64
The dynamic, motile and deformative properties of RNA nanoparticles facilitate the third milestone of drug development	64
Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery	64
Nanoarchitectured two-dimensional layered double hydroxides-based nanocomposites for biomedical applications	63
Stimuli-activatable protein degraders for targeted cancer therapy: from prodrug design to nanoplatform applications	63
Polymer-based nanomedicines: Supporting multimodal approaches to glioblastoma multiforme treatment	63
The tendon microenvironment: Engineered in vitro models to study cellular crosstalk	62
Editorial board members	62
Corrigendum to “Light sheet fluorescence microscopy for monitoring drug delivery: unlocking the developmental phases of embryos” [Adv Drug Del. Rev. 218 (2025) 115520]	62
Recent developments in lactose blend formulations for carrier-based dry powder inhalation	62
Corrigendum to “Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic” [Adv. Drug Delivery Rev. 179 (2021) 114000]	62
Microbubble-assisted ultrasound for inner ear drug delivery	62
Pancreatic organoids as cancer avatars for true personalized medicine	61
Ocular therapies with biomacromolecules: From local injection to eyedrop and emerging noninvasive delivery strategies	61
Nanomedicine for targeting brain Neurodegeneration: Critical barriers and circadian rhythm Considerations	61
Revealing the clinical potential of high-resolution organoids	61
Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors – An update	61
Towards artificial intelligence-enabled extracellular vesicle precision drug delivery	60
Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment	60
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics	59
Biosafety of mesoporous silica nanoparticles; towards clinical translation	59
Laser ablation: Heating up the anti-tumor response in the intracranial compartment	59
Progress of tumor-resident intracellular bacteria for cancer therapy	58
Next generation concepts in dermal delivery, theranostics, and preclinical testing	58

Sustained delivery approaches to improving adaptive immune responses	58
Editorial board members	57
Editorial board members	57
Editorial Board	57
Editorial board members	57
Editorial Board	57
Integrated pharmacokinetic-pharmacodynamic and agent-based modelling in drug development: Current status and future perspectives	56
Theme issue: In vitro mucus models	56
Synergies between data science methods and innovative drug delivery technologies	55
Targeted delivery methods for RNA interference are necessary to obtain a potential functional cure for HIV/AIDS	55
Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria	55
Advances in modular control of CAR-T therapy with adapter-mediated CARs	54
Current issues in optical monitoring of drug delivery via hair follicles	54
Transdermal drug delivery via microneedles to mediate wound microenvironment	54
Advanced oral therapies for colorectal cancer via nanomedicine and microbiota modulation	54
Photonic and magnetic materials for on-demand local drug delivery	54
Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling	54
Recent applications of three-dimensional bioprinting in drug discovery and development	54
Cell-based relay delivery strategy in biomedical applications	53
From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer	53
Precise subcellular targeting approaches for organelle-related disorders	53
Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor	53
Stealth and pseudo-stealth nanocarriers	52
Fungal infections: Immune defense, immunotherapies and vaccines	52
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems	52
The effects of protein corona on in vivo fate of nanocarriers	52
Editorial Board	51
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics	51
Editorial Board	51
Emerging techniques for modeling and simulating subcutaneous injection and fate of drugs after injection	51
Long-acting parenteral drug delivery systems for the treatment of chronic diseases	51
Overcoming barriers and shaping the future: Challenges and innovations in nucleic acid therapies for Glioblastoma	50
Bioengineering toolkits for potentiating organoid therapeutics	50
Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery	50