Trends in Genetics

(The TQCC of Trends in Genetics is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Navigating the DNA methylation landscape of cancer304
Emerging concepts of miRNA therapeutics: from cells to clinic215
Opening the Black Box: Interpretable Machine Learning for Geneticists194
Advances in the Evolutionary Understanding of MHC Polymorphism188
DNA methylation: a historical perspective183
Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies171
Where Are the Disease-Associated eQTLs?160
What Is a Transcriptional Burst?134
DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing128
To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases121
Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation107
Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability99
Classical and noncanonical functions of miRNAs in cancers93
Advances in Chromatin Imaging at Kilobase-Scale Resolution89
Horizontal Gene Transfer in Eukaryotes: Not if, but How Much?82
Fast-forward breeding for a food-secure world82
Retention of duplicated genes in evolution76
The Genomics of Human Local Adaptation72
Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction68
The Role of Noncoding Variants in Heritable Disease67
The Nexus of cfDNA and Nuclease Biology66
The p53 network: cellular and systemic DNA damage responses in cancer and aging66
Anything but Ordinary – Emerging Splicing Mechanisms in Eukaryotic Gene Regulation65
Hotspots of Human Mutation64
Forkhead Transcription Factors in Health and Disease63
Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders63
Towards a Human Cell Atlas: Taking Notes from the Past60
Taming transposable elements in vertebrates: from epigenetic silencing to domestication59
Mitochondrial Diseases: A Diagnostic Revolution59
Relaxed Selection and the Rapid Evolution of Reproductive Genes57
Extrachromosomal circular DNA in cancer: history, current knowledge, and methods56
Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity56
The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway55
Genetic prediction of complex traits with polygenic scores: a statistical review55
How genomics can help biodiversity conservation55
The Epigenetic Drug Discovery Landscape for Metabolic-associated Fatty Liver Disease53
New Approaches for Inferring Phylogenies in the Presence of Paralogs49
Impact of Parental Exposure on Offspring Health in Humans48
Functions of PIWI Proteins in Gene Regulation: New Arrows Added to the piRNA Quiver48
Termination of Transcription by RNA Polymerase II: BOOM!47
Into the multiverse: advances in single-cell multiomic profiling47
On the Molecular Mechanisms Regulating Animal Cell Size Homeostasis47
The multifaceted effects of YTHDC1-mediated nuclear m6A recognition46
Host Polymorphisms May Impact SARS-CoV-2 Infectivity45
Role of Polycomb in the control of transposable elements45
Nonhomologous end joining: new accessory factors fine tune the machinery44
Mitonuclear Compensatory Coevolution44
Transcriptional Silencers: Driving Gene Expression with the Brakes On44
Evolutionary cell type mapping with single-cell genomics43
Beyond sequencing: machine learning algorithms extract biology hidden in Nanopore signal data43
Transcriptional Regulation at DSBs: Mechanisms and Consequences42
Mouse Systems Genetics as a Prelude to Precision Medicine42
Polygenic Adaptation: Integrating Population Genetics and Gene Regulatory Networks41
Histone lactylation: epigenetic mark of glycolytic switch40
Epigenetic Regulators as the Gatekeepers of Hematopoiesis39
Deconstructing Sonic Hedgehog Medulloblastoma: Molecular Subtypes, Drivers, and Beyond39
A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine39
Therapeutic and prognostic insights from the analysis of cancer mutational signatures37
A TAD Skeptic: Is 3D Genome Topology Conserved?37
Base Editing Landscape Extends to Perform Transversion Mutation37
Speed–Specificity Trade-Offs in the Transcription Factors Search for Their Genomic Binding Sites36
Insights from multi-omics integration in complex disease primary tissues36
DNA Damage Triggers a New Phase in Neurodegeneration35
Facilitating Complex Trait Analysis via Reduced Complexity Crosses35
Catastrophic Endgames: Emerging Mechanisms of Telomere-Driven Genomic Instability35
From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation34
Emerging functions of circular RNA in aging34
The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins33
Gene Regulation and Cellular Metabolism: An Essential Partnership33
ADAR1 and its implications in cancer development and treatment33
Somatic mutations provide important and unique insights into the biology of complex diseases32
Exploring the Alternative Splicing of Long Noncoding RNAs32
Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases32
The Y Chromosome as a Battleground for Intragenomic Conflict32
Genome structural variation in human evolution32
APOBECs orchestrate genomic and epigenomic editing across health and disease31
Molecular Clocks without Rocks: New Solutions for Old Problems31
Superspreading in the emergence of COVID-19 variants30
Taming the Turmoil Within: New Insights on the Containment of Transposable Elements29
Site-Specific Recombination – How Simple DNA Inversions Produce Complex Phenotypic Heterogeneity in Bacterial Populations29
Plant Genetic Networks Shaping Phyllosphere Microbial Community29
Evolution of Diverse Strategies for Promoter Regulation29
Symbionts and gene drive: two strategies to combat vector-borne disease28
RNA Editing in Mitochondria and Plastids: Weird and Widespread28
Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility27
Noncanonical DNA structures are drivers of genome evolution26
A devil's bargain with transposable elements in plant pathogens26
From Summary Statistics to Gene Trees: Methods for Inferring Positive Selection26
Bridging biological cfDNA features and machine learning approaches26
Anticipating and Identifying Collateral Damage in Genome Editing26
Networks of Resistance: Small RNA Control of Antibiotic Resistance26
The era of 3D and spatial genomics25
Every gene can (and possibly will) be associated with cancer25
Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance25
Deregulated Regulators: Disease-Causing cis Variants in Transcription Factor Genes25
Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer25
Intricacies of single-cell multi-omics data integration25
State-of-the-art CRISPR for in vivo and cell-based studies in Drosophila25
DNA Damage Response and Metabolic Reprogramming in Health and Disease25
Principles of Epigenetic Homeostasis Shared Between Flowering Plants and Mammals24
Optogenetics for transcriptional programming and genetic engineering24
Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle24
Epimutations Define a Fast-Ticking Molecular Clock in Plants24
Genetic disorders of cellular trafficking24
WRKY transcription factors in plant defense23
DNA N6-methyldeoxyadenosine in mammals and human disease23
Multiple sclerosis: doubling down on MHC23
Elucidation of Biological Networks across Complex Diseases Using Single-Cell Omics23
Advancing human disease research with fish evolutionary mutant models22
The Toll gene in Drosophila pattern formation22
Genetics and Epigenetics of Sex Bias: Insights from Human Cancer and Autoimmunity22
Underappreciated Roles of DNA Polymerase δ in Replication Stress Survival22
Emerging Insights into the Distinctive Neuronal Methylome22
Quo vadis microRNAs?22
Mendelian randomization analyses for PCOS: evidence, opportunities, and challenges22
Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity22
Horizontal Gene Transfer in Vertebrates: A Fishy Tale21
All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics21
Break-induced replication: unraveling each step21
Monarch Butterfly Migration Moving into the Genetic Era21
The H2A.Z-nucleosome code in mammals: emerging functions21
Genetic Variation across Phenotypic Severity of Autism20
Uncovering the impact of noncoding variants in neurodegenerative brain diseases20
Mitochondrial genome engineering coming-of-age20
Genetics in Light of Transcriptional Adaptation20
Biosensing Detection of the SARS-CoV-2 D614G Mutation20
Throwing away DNA: programmed downsizing in somatic nuclei19
New Solutions to Old Problems: Molecular Mechanisms of Meiotic Crossover Control19
Meiotic Executioner Genes Protect the Y from Extinction19
A decade of molecular cell atlases19
Emerging functions of mitochondria-encoded noncoding RNAs19
The evolution of the GALactose utilization pathway in budding yeasts19
Simple Repeats as Building Blocks for Genetic Computers19
Unraveling the Epigenetic Basis of Liver Development, Regeneration and Disease19
SWEET Genes for Disease Resistance in Plants19
Complex genomic rearrangements: an underestimated cause of rare diseases19
The PDE-Opathies: Diverse Phenotypes Produced by a Functionally Related Multigene Family18
Intron retention: importance, challenges, and opportunities18
Regulatory mechanisms ensuring coordinated expression of functionally related genes18
Genetic and epigenetic defects of the RNA modification machinery in cancer18
SpRY: Engineered CRISPR/Cas9 Harnesses New Genome-Editing Power18
Evolutionary Conservation of Transcription Factors Affecting Longevity18
Transcriptional and Epigenetic Regulation of Autophagy in Plants18
Virus-Based CRISPR/Cas9 Genome Editing in Plants17
Dynamic Chromatin Structure and Epigenetics Control the Fate of Malaria Parasites17
Genetically transitional disease: a new concept in genomic medicine16
The cell as a bag of RNA16
'Fly-ing' from rare to common neurodegenerative disease mechanisms16
There is another: H3K27me3-mediated genomic imprinting16
Genetic Variants Affecting Skeletal Morphology in Domestic Dogs15
Potato trait development going fast-forward with genome editing15
Tissue specificity of DNA repair: the CRISPR compass15
DNA base editing in nuclear and organellar genomes15
Chromatin and Nuclear Architecture: Shaping DNA Replication in 3D15
Biology in balance: human diploid genome integrity, gene dosage, and genomic medicine15
Feralization: Confronting the Complexity of Domestication and Evolution15
The sound of silence: mechanisms and implications of HUSH complex function15