Trends in Genetics

Article	Citations
Navigating the DNA methylation landscape of cancer	356
Emerging concepts of miRNA therapeutics: from cells to clinic	284
DNA methylation: a historical perspective	232
Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies	198
Where Are the Disease-Associated eQTLs?	179
DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing	142
To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases	128
Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation	119
Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability	114
Classical and noncanonical functions of miRNAs in cancers	102
Horizontal Gene Transfer in Eukaryotes: Not if, but How Much?	93
Retention of duplicated genes in evolution	87
Fast-forward breeding for a food-secure world	86
The Nexus of cfDNA and Nuclease Biology	86
How genomics can help biodiversity conservation	83
Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction	81
Hotspots of Human Mutation	78
The p53 network: cellular and systemic DNA damage responses in cancer and aging	77
Taming transposable elements in vertebrates: from epigenetic silencing to domestication	72
Anything but Ordinary – Emerging Splicing Mechanisms in Eukaryotic Gene Regulation	71
Extrachromosomal circular DNA in cancer: history, current knowledge, and methods	71
The Role of Noncoding Variants in Heritable Disease	71
Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders	68
Forkhead Transcription Factors in Health and Disease	67
Relaxed Selection and the Rapid Evolution of Reproductive Genes	67

Mitochondrial Diseases: A Diagnostic Revolution	67
Genetic prediction of complex traits with polygenic scores: a statistical review	65
Towards a Human Cell Atlas: Taking Notes from the Past	63
Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity	59
The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway	59
Into the multiverse: advances in single-cell multiomic profiling	56
New Approaches for Inferring Phylogenies in the Presence of Paralogs	54
Impact of Parental Exposure on Offspring Health in Humans	54
Histone lactylation: epigenetic mark of glycolytic switch	54
Termination of Transcription by RNA Polymerase II: BOOM!	54
Beyond sequencing: machine learning algorithms extract biology hidden in Nanopore signal data	52
The multifaceted effects of YTHDC1-mediated nuclear m6A recognition	52
Transcriptional Silencers: Driving Gene Expression with the Brakes On	51
Evolutionary cell type mapping with single-cell genomics	51
Role of Polycomb in the control of transposable elements	50
Functions of PIWI Proteins in Gene Regulation: New Arrows Added to the piRNA Quiver	50
Transcriptional Regulation at DSBs: Mechanisms and Consequences	48
Nonhomologous end joining: new accessory factors fine tune the machinery	48
Therapeutic and prognostic insights from the analysis of cancer mutational signatures	46
Host Polymorphisms May Impact SARS-CoV-2 Infectivity	45
Deconstructing Sonic Hedgehog Medulloblastoma: Molecular Subtypes, Drivers, and Beyond	45
Insights from multi-omics integration in complex disease primary tissues	44
Polygenic Adaptation: Integrating Population Genetics and Gene Regulatory Networks	44
ADAR1 and its implications in cancer development and treatment	42
Epigenetic Regulators as the Gatekeepers of Hematopoiesis	42
Speed–Specificity Trade-Offs in the Transcription Factors Search for Their Genomic Binding Sites	41
From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation	40
A TAD Skeptic: Is 3D Genome Topology Conserved?	40
Gene Regulation and Cellular Metabolism: An Essential Partnership	39
Base Editing Landscape Extends to Perform Transversion Mutation	39
Emerging functions of circular RNA in aging	39
WRKY transcription factors in plant defense	38
Genome structural variation in human evolution	38
DNA Damage Triggers a New Phase in Neurodegeneration	38
Bridging biological cfDNA features and machine learning approaches	38
Somatic mutations provide important and unique insights into the biology of complex diseases	37
Symbionts and gene drive: two strategies to combat vector-borne disease	36
Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases	36
Facilitating Complex Trait Analysis via Reduced Complexity Crosses	36
Molecular Clocks without Rocks: New Solutions for Old Problems	35
Exploring the Alternative Splicing of Long Noncoding RNAs	35
Noncanonical DNA structures are drivers of genome evolution	35
Epimutations Define a Fast-Ticking Molecular Clock in Plants	35
The Y Chromosome as a Battleground for Intragenomic Conflict	34
Superspreading in the emergence of COVID-19 variants	32
Plant Genetic Networks Shaping Phyllosphere Microbial Community	32
Anticipating and Identifying Collateral Damage in Genome Editing	32
APOBECs orchestrate genomic and epigenomic editing across health and disease	31
Taming the Turmoil Within: New Insights on the Containment of Transposable Elements	30
RNA Editing in Mitochondria and Plastids: Weird and Widespread	30

Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility	30
Site-Specific Recombination – How Simple DNA Inversions Produce Complex Phenotypic Heterogeneity in Bacterial Populations	30
State-of-the-art CRISPR for in vivo and cell-based studies in Drosophila	29
Evolution of Diverse Strategies for Promoter Regulation	29
The era of 3D and spatial genomics	29
Networks of Resistance: Small RNA Control of Antibiotic Resistance	29
Genetic and epigenetic defects of the RNA modification machinery in cancer	29
A devil's bargain with transposable elements in plant pathogens	29
Break-induced replication: unraveling each step	28
DNA Damage Response and Metabolic Reprogramming in Health and Disease	28
Optogenetics for transcriptional programming and genetic engineering	27
Deregulated Regulators: Disease-Causing cis Variants in Transcription Factor Genes	27
Genomics in the long-read sequencing era	27
Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer	27
Intricacies of single-cell multi-omics data integration	26
Mendelian randomization analyses for PCOS: evidence, opportunities, and challenges	26
Multiple sclerosis: doubling down on MHC	26
Future of DNA-based insect monitoring	26
Principles of Epigenetic Homeostasis Shared Between Flowering Plants and Mammals	26
Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle	26
Genetic disorders of cellular trafficking	26
The H2A.Z-nucleosome code in mammals: emerging functions	26
The Toll gene in Drosophila pattern formation	26
Elucidation of Biological Networks across Complex Diseases Using Single-Cell Omics	25
Every gene can (and possibly will) be associated with cancer	25
Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance	25
A decade of molecular cell atlases	24
Genetics and Epigenetics of Sex Bias: Insights from Human Cancer and Autoimmunity	24
Quo vadis microRNAs?	24
Complex genomic rearrangements: an underestimated cause of rare diseases	24
Advancing human disease research with fish evolutionary mutant models	24
Underappreciated Roles of DNA Polymerase δ in Replication Stress Survival	23
DNA N6-methyldeoxyadenosine in mammals and human disease	23
Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity	23
All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics	23
Transcriptional and Epigenetic Regulation of Autophagy in Plants	22
Emerging functions of mitochondria-encoded noncoding RNAs	22
Emerging Insights into the Distinctive Neuronal Methylome	22
Horizontal Gene Transfer in Vertebrates: A Fishy Tale	22
ATRX, a guardian of chromatin	22
Monarch Butterfly Migration Moving into the Genetic Era	22
Uncovering the impact of noncoding variants in neurodegenerative brain diseases	22
Mitochondrial genome engineering coming-of-age	22
The evolution of the GALactose utilization pathway in budding yeasts	22
Genetics in Light of Transcriptional Adaptation	21
Unraveling the Epigenetic Basis of Liver Development, Regeneration and Disease	21
iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies	21
Dynamic Chromatin Structure and Epigenetics Control the Fate of Malaria Parasites	21
Throwing away DNA: programmed downsizing in somatic nuclei	21
Feralization: Confronting the Complexity of Domestication and Evolution	20
Intron retention: importance, challenges, and opportunities	20
There is another: H3K27me3-mediated genomic imprinting	20
Genetically transitional disease: a new concept in genomic medicine	20
SWEET Genes for Disease Resistance in Plants	20
The PDE-Opathies: Diverse Phenotypes Produced by a Functionally Related Multigene Family	20
Biosensing Detection of the SARS-CoV-2 D614G Mutation	20
Simple Repeats as Building Blocks for Genetic Computers	19
'Fly-ing' from rare to common neurodegenerative disease mechanisms	19
Machine learning approaches to explore digenic inheritance	19
Meiotic Executioner Genes Protect the Y from Extinction	19
Germline Variants That Affect Tumor Progression	18
The sound of silence: mechanisms and implications of HUSH complex function	18
First discovered, long out of sight, finally visible: ribosomal DNA	18
SpRY: Engineered CRISPR/Cas9 Harnesses New Genome-Editing Power	18
Regulatory mechanisms ensuring coordinated expression of functionally related genes	18
Virus-Based CRISPR/Cas9 Genome Editing in Plants	18
DNA base editing in nuclear and organellar genomes	17
The cell as a bag of RNA	17
Potato trait development going fast-forward with genome editing	17
Evolutionary conservation in noncoding genomic regions	17
A proposed metric set for evaluation of genome assembly quality	16
Trash Talk: Mammalian Proteasome Regulation at the Transcriptional Level	16
Sperm mosaicism: implications for genomic diversity and disease	16
Biology in balance: human diploid genome integrity, gene dosage, and genomic medicine	16
Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics	16
Mediator Roles Going Beyond Transcription	15
Phenotype-aware prioritisation of rare Mendelian disease variants	15
Mitochondria and G-quadruplex evolution: an intertwined relationship	15
Tissue specificity of DNA repair: the CRISPR compass	15
Alternative Synaptonemal Complex Structures: Too Much of a Good Thing?	15

miRNA biogenesis and inherited disorders: clinico-molecular insights	15
Deciphering pathogenicity of variants of uncertain significance with CRISPR-edited iPSCs	15
Current concepts, advances, and challenges in deciphering the human microbiota with metatranscriptomics	15
Rare variants and the oligogenic architecture of autism	15
Is CpG Density the Link between Epigenetic Aging and Lifespan?	15
Genetic Variants Affecting Skeletal Morphology in Domestic Dogs	15
Chromatin and Nuclear Architecture: Shaping DNA Replication in 3D	15