Trends in Genetics

Article	Citations
Navigating the DNA methylation landscape of cancer	290
Molecular Mechanisms Driving mRNA Degradation by m6A Modification	234
Emerging concepts of miRNA therapeutics: from cells to clinic	198
Opening the Black Box: Interpretable Machine Learning for Geneticists	185
Advances in the Evolutionary Understanding of MHC Polymorphism	181
DNA methylation: a historical perspective	166
Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies	161
Where Are the Disease-Associated eQTLs?	156
What Is a Transcriptional Burst?	129
DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing	121
To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases	115
Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation	100
Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability	97
Classical and noncanonical functions of miRNAs in cancers	92
Advances in Chromatin Imaging at Kilobase-Scale Resolution	86
Fast-forward breeding for a food-secure world	80
Horizontal Gene Transfer in Eukaryotes: Not if, but How Much?	77
Retention of duplicated genes in evolution	72
The Genomics of Human Local Adaptation	71
The Role of Noncoding Variants in Heritable Disease	65
Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction	64
Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders	63
Small RNAs in the Transgenerational Inheritance of Epigenetic Information	63
Forkhead Transcription Factors in Health and Disease	62
The p53 network: cellular and systemic DNA damage responses in cancer and aging	62

Anything but Ordinary – Emerging Splicing Mechanisms in Eukaryotic Gene Regulation	62
The Nexus of cfDNA and Nuclease Biology	61
Hotspots of Human Mutation	59
Mitochondrial Diseases: A Diagnostic Revolution	59
Towards a Human Cell Atlas: Taking Notes from the Past	59
Relaxed Selection and the Rapid Evolution of Reproductive Genes	57
Taming transposable elements in vertebrates: from epigenetic silencing to domestication	56
Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity	55
Extrachromosomal circular DNA in cancer: history, current knowledge, and methods	53
The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway	53
The Epigenetic Drug Discovery Landscape for Metabolic-associated Fatty Liver Disease	52
Genetic prediction of complex traits with polygenic scores: a statistical review	52
How genomics can help biodiversity conservation	49
Impact of Parental Exposure on Offspring Health in Humans	48
New Approaches for Inferring Phylogenies in the Presence of Paralogs	47
On the Molecular Mechanisms Regulating Animal Cell Size Homeostasis	47
Functions of PIWI Proteins in Gene Regulation: New Arrows Added to the piRNA Quiver	46
Host Polymorphisms May Impact SARS-CoV-2 Infectivity	45
Nonhomologous end joining: new accessory factors fine tune the machinery	44
Termination of Transcription by RNA Polymerase II: BOOM!	44
The multifaceted effects of YTHDC1-mediated nuclear m6A recognition	44
Transcriptional Silencers: Driving Gene Expression with the Brakes On	44
Role of Polycomb in the control of transposable elements	44
Mitonuclear Compensatory Coevolution	43
Into the multiverse: advances in single-cell multiomic profiling	43
Transcriptional Regulation at DSBs: Mechanisms and Consequences	41
Mouse Systems Genetics as a Prelude to Precision Medicine	41
Polygenic Adaptation: Integrating Population Genetics and Gene Regulatory Networks	40
Evolutionary cell type mapping with single-cell genomics	40
Beyond sequencing: machine learning algorithms extract biology hidden in Nanopore signal data	39
A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine	39
Epigenetic Regulators as the Gatekeepers of Hematopoiesis	38
Deconstructing Sonic Hedgehog Medulloblastoma: Molecular Subtypes, Drivers, and Beyond	38
A TAD Skeptic: Is 3D Genome Topology Conserved?	37
Histone lactylation: epigenetic mark of glycolytic switch	37
Base Editing Landscape Extends to Perform Transversion Mutation	36
Therapeutic and prognostic insights from the analysis of cancer mutational signatures	36
Speed–Specificity Trade-Offs in the Transcription Factors Search for Their Genomic Binding Sites	36
Facilitating Complex Trait Analysis via Reduced Complexity Crosses	34
Catastrophic Endgames: Emerging Mechanisms of Telomere-Driven Genomic Instability	34
DNA Damage Triggers a New Phase in Neurodegeneration	34
From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation	33
Insights from multi-omics integration in complex disease primary tissues	33
The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins	33
Exploring the Alternative Splicing of Long Noncoding RNAs	32
The Y Chromosome as a Battleground for Intragenomic Conflict	32
Emerging functions of circular RNA in aging	32
Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases	32
Molecular Clocks without Rocks: New Solutions for Old Problems	31
Gene Regulation and Cellular Metabolism: An Essential Partnership	31

ADAR1 and its implications in cancer development and treatment	31
Superspreading in the emergence of COVID-19 variants	30
Somatic mutations provide important and unique insights into the biology of complex diseases	30
Genome structural variation in human evolution	30
Taming the Turmoil Within: New Insights on the Containment of Transposable Elements	29
Plant Genetic Networks Shaping Phyllosphere Microbial Community	29
Evolution of Diverse Strategies for Promoter Regulation	29
Omics in Neurodegenerative Disease: Hope or Hype?	28
Site-Specific Recombination – How Simple DNA Inversions Produce Complex Phenotypic Heterogeneity in Bacterial Populations	28
RNA Editing in Mitochondria and Plastids: Weird and Widespread	27
Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility	27
APOBECs orchestrate genomic and epigenomic editing across health and disease	26
From Summary Statistics to Gene Trees: Methods for Inferring Positive Selection	26
Symbionts and gene drive: two strategies to combat vector-borne disease	26
State-of-the-art CRISPR for in vivo and cell-based studies in Drosophila	25
DNA Damage Response and Metabolic Reprogramming in Health and Disease	25
Every gene can (and possibly will) be associated with cancer	25
A devil's bargain with transposable elements in plant pathogens	25
Anticipating and Identifying Collateral Damage in Genome Editing	25
Networks of Resistance: Small RNA Control of Antibiotic Resistance	25
Deregulated Regulators: Disease-Causing cis Variants in Transcription Factor Genes	24
Epimutations Define a Fast-Ticking Molecular Clock in Plants	24
Intricacies of single-cell multi-omics data integration	24
Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance	24
Noncanonical DNA structures are drivers of genome evolution	23
Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle	23
Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer	23
Principles of Epigenetic Homeostasis Shared Between Flowering Plants and Mammals	23
Bridging biological cfDNA features and machine learning approaches	23
Silencers, Enhancers, and the Multifunctional Regulatory Genome	23
Elucidation of Biological Networks across Complex Diseases Using Single-Cell Omics	23
Emerging Insights into the Distinctive Neuronal Methylome	22
Quo vadis microRNAs?	22
Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity	22
DNA N6-methyldeoxyadenosine in mammals and human disease	22
Genetics and Epigenetics of Sex Bias: Insights from Human Cancer and Autoimmunity	22
Genetic disorders of cellular trafficking	22
Advancing human disease research with fish evolutionary mutant models	22
Optogenetics for transcriptional programming and genetic engineering	21
Underappreciated Roles of DNA Polymerase δ in Replication Stress Survival	21
Multiple sclerosis: doubling down on MHC	21
The era of 3D and spatial genomics	21
Monarch Butterfly Migration Moving into the Genetic Era	21
Clonal Reproduction through Seeds in Sight for Crops	21
The Toll gene in Drosophila pattern formation	21
All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics	21
Genetics in Light of Transcriptional Adaptation	20
Mitochondrial genome engineering coming-of-age	20
Biosensing Detection of the SARS-CoV-2 D614G Mutation	20
Genetic Variation across Phenotypic Severity of Autism	19
The H2A.Z-nucleosome code in mammals: emerging functions	19
SWEET Genes for Disease Resistance in Plants	19
Simple Repeats as Building Blocks for Genetic Computers	19
Unraveling the Epigenetic Basis of Liver Development, Regeneration and Disease	19
New Solutions to Old Problems: Molecular Mechanisms of Meiotic Crossover Control	19
Horizontal Gene Transfer in Vertebrates: A Fishy Tale	19
Break-induced replication: unraveling each step	19
The evolution of the GALactose utilization pathway in budding yeasts	19
Meiotic Executioner Genes Protect the Y from Extinction	19
Complex genomic rearrangements: an underestimated cause of rare diseases	18
Mendelian randomization analyses for PCOS: evidence, opportunities, and challenges	18
Transcriptional and Epigenetic Regulation of Autophagy in Plants	18
SpRY: Engineered CRISPR/Cas9 Harnesses New Genome-Editing Power	18
Evolutionary Conservation of Transcription Factors Affecting Longevity	18
A decade of molecular cell atlases	18
Dynamic Chromatin Structure and Epigenetics Control the Fate of Malaria Parasites	17
Emerging functions of mitochondria-encoded noncoding RNAs	17
The PDE-Opathies: Diverse Phenotypes Produced by a Functionally Related Multigene Family	17
Uncovering the impact of noncoding variants in neurodegenerative brain diseases	17
Throwing away DNA: programmed downsizing in somatic nuclei	17
There is another: H3K27me3-mediated genomic imprinting	16
Virus-Based CRISPR/Cas9 Genome Editing in Plants	16
Genetically transitional disease: a new concept in genomic medicine	16
Intron retention: importance, challenges, and opportunities	16
The cell as a bag of RNA	16
'Fly-ing' from rare to common neurodegenerative disease mechanisms	16
WRKY transcription factors in plant defense	15
Chromatin and Nuclear Architecture: Shaping DNA Replication in 3D	15
Genetic Variants Affecting Skeletal Morphology in Domestic Dogs	15
Picking Winners and Losers: Cell Competition in Tissue Development and Homeostasis	14

Genetic and epigenetic defects of the RNA modification machinery in cancer	14
Autosomal Clonal Monoallelic Expression: Natural or Artifactual?	14
Alternative Synaptonemal Complex Structures: Too Much of a Good Thing?	14
DNA base editing in nuclear and organellar genomes	14
Trash Talk: Mammalian Proteasome Regulation at the Transcriptional Level	14
Regulatory mechanisms ensuring coordinated expression of functionally related genes	14
Biology in balance: human diploid genome integrity, gene dosage, and genomic medicine	14
Germline Variants That Affect Tumor Progression	14
ATRX, a guardian of chromatin	13
Recursive Test of Hardy-Weinberg Equilibrium in Tetraploids	13
Unbelievable but True: Epigenetics and Chromatin in Fungi	13
Rare variants and the oligogenic architecture of autism	13
Is CpG Density the Link between Epigenetic Aging and Lifespan?	13
Feralization: Confronting the Complexity of Domestication and Evolution	13
The sound of silence: mechanisms and implications of HUSH complex function	13
Tissue specificity of DNA repair: the CRISPR compass	13
Mediator Roles Going Beyond Transcription	13
Evolutionary conservation in noncoding genomic regions	13
Quantitative genetics: pan-genomes, SVs, and k-mers for GWAS	13
Equity in Health: Consideration of Race and Ethnicity in Precision Medicine	13
CD225 Proteins: A Family Portrait of Fusion Regulators	13
Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome	12
Breakage in breakage–fusion–bridge cycle: an 80-year-old mystery	12
Deciphering pathogenicity of variants of uncertain significance with CRISPR-edited iPSCs	12
Cohesin Biology: From Passive Rings to Molecular Motors	12
Keeping Up with RNA-Based Regulation in Bacteria: New Roles for RNA Binding Proteins	12
Potato trait development going fast-forward with genome editing	12
The Muller’s Ratchet and Aging	12
Future of DNA-based insect monitoring	12
Machine learning approaches to explore digenic inheritance	12
Sperm mosaicism: implications for genomic diversity and disease	12
The H2A.Z-nucleosome code in mammals: emerging functions	11
iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies	11
Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics	11
Genomic instability signals offer diagnostic possibility in early cancer detection	11
Genomics in the long-read sequencing era	11
The Invisible University Is COVID-19 Positive	11
How does genetic variation modify ND-CNV phenotypes?	11
Gaining insight into metabolic diseases from human genetic discoveries	11
The Emerging Roles of Cytosine-5 Methylation in mRNAs	11
Transcriptional enhancers at 40: evolution of a viral DNA element to nuclear architectural structures	11
In The Blood: Connecting Variant to Function In Human Hematopoiesis	11
Protein Bait Hypothesis: circRNA-Encoded Proteins Competitively Inhibit Cognate Functional Isoforms	11
Integration of DNA damage responses with dynamic spatial genome organization	11
Using Genetic and Species Diversity to Tackle Kidney Disease	11
Flipping Shells! Unwinding LR Asymmetry in Mirror-Image Molluscs	10
Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells	10
Tracking the Genomic Footprints of SARS-CoV-2 Transmission	10
Non-homologous end-joining at challenged replication forks: an RNA connection?	10
Swamp eel (Monopterus albus)	10
Ancient Memories of Seeds: ABA-Dependent Growth Arrest and Reserve Accumulation	10
Chromatin modules and their implication in genomic organization and gene regulation	10
The essential but enigmatic regulatory role of HERVH in pluripotency	10
miRNA biogenesis and inherited disorders: clinico-molecular insights	10
Interpreting omics data with pathway enrichment analysis	10
Chemical Embryology Redux: Metabolic Control of Development	10
Nothobranchius furzeri (African Turquoise Killifish)	9
Ailurus fulgens (Himalayan Red Panda) and Ailurus styani (Chinese Red Panda)	9
Maturation and application of phenome-wide association studies	9
Mitochondria and G-quadruplex evolution: an intertwined relationship	9
Pursuing totipotency: authentic totipotent stem cells in culture	9
Transgenerational epigenetic impacts of parental infection on offspring health and disease susceptibility	9
Ginkgo biloba	9
Noncoding RNAs Set the Stage for RNA Polymerase II Transcription	9
First discovered, long out of sight, finally visible: ribosomal DNA	9
Repetitive elements in aging and neurodegeneration	9
Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines	9
Singling out motor neurons in the age of single-cell transcriptomics	9
Without mechanisms, theories and models in insect epigenetics remain a black box	9
The Genetic Discrimination Observatory: confronting novel issues in genetic discrimination	9
RNAPII driven post-translational modifications of nucleosomal histones	9
Predicting genome organisation and function with mechanistic modelling	9
Positive and Negative Regulation of DNA Replication Initiation	8
Clinical progress in genome-editing technology and in vivo delivery techniques	8
Small RNA-mediated genome rearrangement pathways in ciliates	8
The genome atlas: navigating a new era of reference genomes	8
Current concepts, advances, and challenges in deciphering the human microbiota with metatranscriptomics	8
Driving to Safety: CRISPR-Based Genetic Approaches to Reducing Antibiotic Resistance	8
From genome size to trait evolution during angiosperm radiation	8
Interplay between regulatory elements and chromatin topology in cellular lineage determination	8
Mapping chromatin loops in single cells	8
Camellia sinensis (Tea)	8
Gene-dosage issues: a recurrent theme in whole genome duplication events	8
Chromosome-scale haplotype-resolved pangenomics	8
A current guide to candidate gene association studies	8
Read, Write, Adapt: Challenges and Opportunities during Kinetoplastid Genome Replication	8
The versatile relationships between eIF4E and eIF4E-interacting proteins	8
lncRNAs in fertility: redefining the gene expression paradigm?	7
Aegilops tauschii presents a genetic roadmap for hexaploid wheat improvement	7
Heritable epigenetic changes at single genes: challenges and opportunities in Caenorhabditis elegans	7
Challenges of Genetic Data Sharing in African Studies	7
Unpacking chromatin remodelling in germ cells: implications for development and evolution	7
The Consequences of Abnormal Gene Dosage: Lessons from Chromosome 18	7
Epigenetic control of muscle stem cells: time for a new dimension	7
Epigenetic Regulation of Tick Biology and Vectorial Capacity	7