Trends in Genetics

Article	Citations
Navigating the DNA methylation landscape of cancer	425
Emerging concepts of miRNA therapeutics: from cells to clinic	342
DNA methylation: a historical perspective	290
Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies	226
Where Are the Disease-Associated eQTLs?	198
DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing	168
To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases	142
Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation	131
Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability	123
How genomics can help biodiversity conservation	115
Classical and noncanonical functions of miRNAs in cancers	114
Horizontal Gene Transfer in Eukaryotes: Not if, but How Much?	103
The Nexus of cfDNA and Nuclease Biology	101
Retention of duplicated genes in evolution	100
Fast-forward breeding for a food-secure world	91
The p53 network: cellular and systemic DNA damage responses in cancer and aging	89
Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction	89
Hotspots of Human Mutation	83
Taming transposable elements in vertebrates: from epigenetic silencing to domestication	81
Extrachromosomal circular DNA in cancer: history, current knowledge, and methods	78
The Role of Noncoding Variants in Heritable Disease	75
Anything but Ordinary – Emerging Splicing Mechanisms in Eukaryotic Gene Regulation	75
Genetic prediction of complex traits with polygenic scores: a statistical review	71
Histone lactylation: epigenetic mark of glycolytic switch	71
Forkhead Transcription Factors in Health and Disease	70

Towards a Human Cell Atlas: Taking Notes from the Past	67
Into the multiverse: advances in single-cell multiomic profiling	61
Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity	61
The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway	60
The multifaceted effects of YTHDC1-mediated nuclear m6A recognition	58
Impact of Parental Exposure on Offspring Health in Humans	57
Evolutionary cell type mapping with single-cell genomics	56
New Approaches for Inferring Phylogenies in the Presence of Paralogs	56
Beyond sequencing: machine learning algorithms extract biology hidden in Nanopore signal data	56
Role of Polycomb in the control of transposable elements	53
Functions of PIWI Proteins in Gene Regulation: New Arrows Added to the piRNA Quiver	53
Transcriptional Silencers: Driving Gene Expression with the Brakes On	52
Nonhomologous end joining: new accessory factors fine tune the machinery	52
ADAR1 and its implications in cancer development and treatment	51
Gene Regulation and Cellular Metabolism: An Essential Partnership	50
WRKY transcription factors in plant defense	50
Deconstructing Sonic Hedgehog Medulloblastoma: Molecular Subtypes, Drivers, and Beyond	50
Polygenic Adaptation: Integrating Population Genetics and Gene Regulatory Networks	49
Transcriptional Regulation at DSBs: Mechanisms and Consequences	49
Therapeutic and prognostic insights from the analysis of cancer mutational signatures	48
Insights from multi-omics integration in complex disease primary tissues	48
Epigenetic Regulators as the Gatekeepers of Hematopoiesis	47
Host Polymorphisms May Impact SARS-CoV-2 Infectivity	46
Speed–Specificity Trade-Offs in the Transcription Factors Search for Their Genomic Binding Sites	44
Noncanonical DNA structures are drivers of genome evolution	44
Genetic and epigenetic defects of the RNA modification machinery in cancer	43
DNA Damage Triggers a New Phase in Neurodegeneration	43
Bridging biological cfDNA features and machine learning approaches	43
A TAD Skeptic: Is 3D Genome Topology Conserved?	42
From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation	41
Symbionts and gene drive: two strategies to combat vector-borne disease	41
Somatic mutations provide important and unique insights into the biology of complex diseases	41
Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases	40
Emerging functions of circular RNA in aging	40
Genomics in the long-read sequencing era	40
Genome structural variation in human evolution	39
Base Editing Landscape Extends to Perform Transversion Mutation	39
Molecular Clocks without Rocks: New Solutions for Old Problems	39
Epimutations Define a Fast-Ticking Molecular Clock in Plants	39
Exploring the Alternative Splicing of Long Noncoding RNAs	38
Networks of Resistance: Small RNA Control of Antibiotic Resistance	36
Genetic disorders of cellular trafficking	35
The H2A.Z-nucleosome code in mammals: emerging functions	35
The era of 3D and spatial genomics	34
Plant Genetic Networks Shaping Phyllosphere Microbial Community	34
Break-induced replication: unraveling each step	33
Superspreading in the emergence of COVID-19 variants	33
Site-Specific Recombination – How Simple DNA Inversions Produce Complex Phenotypic Heterogeneity in Bacterial Populations	33
APOBECs orchestrate genomic and epigenomic editing across health and disease	33
RNA Editing in Mitochondria and Plastids: Weird and Widespread	33

Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer	32
State-of-the-art CRISPR for in vivo and cell-based studies in Drosophila	32
Mendelian randomization analyses for PCOS: evidence, opportunities, and challenges	32
Anticipating and Identifying Collateral Damage in Genome Editing	32
Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility	31
Future of DNA-based insect monitoring	31
Optogenetics for transcriptional programming and genetic engineering	31
Complex genomic rearrangements: an underestimated cause of rare diseases	30
A devil's bargain with transposable elements in plant pathogens	30
The Toll gene in Drosophila pattern formation	30
Intricacies of single-cell multi-omics data integration	29
Evolution of Diverse Strategies for Promoter Regulation	29
The sound of silence: mechanisms and implications of HUSH complex function	28
Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance	28
A decade of molecular cell atlases	28
DNA N6-methyldeoxyadenosine in mammals and human disease	27
Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle	27
Advancing human disease research with fish evolutionary mutant models	27
Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity	27
ATRX, a guardian of chromatin	27
Multiple sclerosis: doubling down on MHC	27
Emerging functions of mitochondria-encoded noncoding RNAs	26
Elucidation of Biological Networks across Complex Diseases Using Single-Cell Omics	25
iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies	25
Horizontal Gene Transfer in Vertebrates: A Fishy Tale	24
All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics	24
Uncovering the impact of noncoding variants in neurodegenerative brain diseases	24
The evolution of the GALactose utilization pathway in budding yeasts	24
Every gene can (and possibly will) be associated with cancer	24
Underappreciated Roles of DNA Polymerase δ in Replication Stress Survival	23
Genetics in Light of Transcriptional Adaptation	23
Emerging Insights into the Distinctive Neuronal Methylome	23
Genetically transitional disease: a new concept in genomic medicine	23
Intron retention: importance, challenges, and opportunities	23
Dynamic Chromatin Structure and Epigenetics Control the Fate of Malaria Parasites	22
Evolutionary conservation in noncoding genomic regions	22
SWEET Genes for Disease Resistance in Plants	22
The PDE-Opathies: Diverse Phenotypes Produced by a Functionally Related Multigene Family	22
Mitochondrial genome engineering coming-of-age	22
There is another: H3K27me3-mediated genomic imprinting	22
Mitochondria and G-quadruplex evolution: an intertwined relationship	22
Regulatory mechanisms ensuring coordinated expression of functionally related genes	21
Throwing away DNA: programmed downsizing in somatic nuclei	21
Biosensing Detection of the SARS-CoV-2 D614G Mutation	20
DNA base editing in nuclear and organellar genomes	20
Virus-Based CRISPR/Cas9 Genome Editing in Plants	20
Machine learning approaches to explore digenic inheritance	20
First discovered, long out of sight, finally visible: ribosomal DNA	20
Repetitive elements in aging and neurodegeneration	20
Feralization: Confronting the Complexity of Domestication and Evolution	20
Germline Variants That Affect Tumor Progression	20
Rare variants and the oligogenic architecture of autism	19
'Fly-ing' from rare to common neurodegenerative disease mechanisms	19
The cell as a bag of RNA	19
miRNA biogenesis and inherited disorders: clinico-molecular insights	19
Pioneer factors: roles and their regulation in development	18
A proposed metric set for evaluation of genome assembly quality	18
Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics	18
Gene product diversity: adaptive or not?	18
Potato trait development going fast-forward with genome editing	18
Sperm mosaicism: implications for genomic diversity and disease	17
Alternative Synaptonemal Complex Structures: Too Much of a Good Thing?	17
Biology in balance: human diploid genome integrity, gene dosage, and genomic medicine	17
Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome	16
Recursive Test of Hardy-Weinberg Equilibrium in Tetraploids	16
Current concepts, advances, and challenges in deciphering the human microbiota with metatranscriptomics	16
Autosomal Clonal Monoallelic Expression: Natural or Artifactual?	16
Take a walk on the KRAB side	16
Interpreting omics data with pathway enrichment analysis	16
Chromatin and Nuclear Architecture: Shaping DNA Replication in 3D	16
Trash Talk: Mammalian Proteasome Regulation at the Transcriptional Level	16
Clinical progress in genome-editing technology and in vivo delivery techniques	16
Breakage in breakage–fusion–bridge cycle: an 80-year-old mystery	16
Deciphering pathogenicity of variants of uncertain significance with CRISPR-edited iPSCs	16
Integration of DNA damage responses with dynamic spatial genome organization	16
The essential but enigmatic regulatory role of HERVH in pluripotency	15
Transgenerational epigenetic impacts of parental infection on offspring health and disease susceptibility	15
Ginkgo biloba	15
The Emerging Roles of Cytosine-5 Methylation in mRNAs	15
Phenotype-aware prioritisation of rare Mendelian disease variants	15

Chromatin modules and their implication in genomic organization and gene regulation	15
Tissue specificity of DNA repair: the CRISPR compass	15
CD225 Proteins: A Family Portrait of Fusion Regulators	15
Quantitative genetics: pan-genomes, SVs, and k-mers for GWAS	15
From genome size to trait evolution during angiosperm radiation	14
Protein Bait Hypothesis: circRNA-Encoded Proteins Competitively Inhibit Cognate Functional Isoforms	14
Gaining insight into metabolic diseases from human genetic discoveries	14
Mediator Roles Going Beyond Transcription	14
Whole-genome doubling in tissues and tumors	14
Heritable epigenetic changes at single genes: challenges and opportunities in Caenorhabditis elegans	14
Keeping Up with RNA-Based Regulation in Bacteria: New Roles for RNA Binding Proteins	14
Non-homologous end-joining at challenged replication forks: an RNA connection?	14
Unbelievable but True: Epigenetics and Chromatin in Fungi	14
A current guide to candidate gene association studies	13
Time will tell: comparing timescales to gain insight into transcriptional bursting	13
Singling out motor neurons in the age of single-cell transcriptomics	13
Genomic instability signals offer diagnostic possibility in early cancer detection	13
How does genetic variation modify ND-CNV phenotypes?	13
Equity in Health: Consideration of Race and Ethnicity in Precision Medicine	13
Transcriptional enhancers at 40: evolution of a viral DNA element to nuclear architectural structures	12
Interplay between regulatory elements and chromatin topology in cellular lineage determination	12
Maturation and application of phenome-wide association studies	12
The evolution of aging and lifespan	12
Functional characterization of human genomic variation linked to polygenic diseases	12
The H2A.Z-nucleosome code in mammals: emerging functions	12
In search of critical dsRNA targets of ADAR1	12
Pre-mRNA splicing and its cotranscriptional connections	12
Opportunities and tradeoffs in single-cell transcriptomic technologies	12
RNAPII driven post-translational modifications of nucleosomal histones	12
Predicting genome organisation and function with mechanistic modelling	12
Polygenic sex determination in vertebrates – is there any such thing?	12
Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells	12
Fluctuating selection and the determinants of genetic variation	12
Experimental evolution of extremophile resistance to ionizing radiation	12
Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification	12
Small RNA-mediated genome rearrangement pathways in ciliates	11
Aegilops tauschii presents a genetic roadmap for hexaploid wheat improvement	11
The versatile relationships between eIF4E and eIF4E-interacting proteins	11
Chromosome-scale haplotype-resolved pangenomics	11
Read, Write, Adapt: Challenges and Opportunities during Kinetoplastid Genome Replication	11
The Genetic Discrimination Observatory: confronting novel issues in genetic discrimination	11
Earth Biogenome Project: present status and future plans	11
Without mechanisms, theories and models in insect epigenetics remain a black box	11
Pursuing totipotency: authentic totipotent stem cells in culture	11
Swamp eel (Monopterus albus)	11
Chinese pine (Pinus tabuliformis Carr.)	10
Advances in integrative African genomics	10
Camellia sinensis (Tea)	10
Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines	10
Haemaphysalis longicornis	10
Dynamics of the Streptomyces chromosome: chance and necessity	10
Gene-dosage issues: a recurrent theme in whole genome duplication events	10
Predicting RNA structures and functions by artificial intelligence	10
Mapping chromatin loops in single cells	10
Epigenetic control of muscle stem cells: time for a new dimension	10
Advances in methods for tRNA sequencing and quantification	9
Cyprinus carpio (common carp)	9
Studying transcription factor function in the genome at molecular resolution	9
Slippy-Sloppy translation: a tale of programmed and induced-ribosomal frameshifting	9
Aneuploidy in human cancer: new tools and perspectives	9
New technologies for improved relevance in miRNA research	9
The genome atlas: navigating a new era of reference genomes	9
Making connections: enhancers in cellular differentiation	9
Retrotransposon renaissance in early embryos	9
Noncoding RNAs Set the Stage for RNA Polymerase II Transcription	9
Telomeres expand sphere of influence: emerging molecular impact of telomeres in non-telomeric functions	8
Preventing excess replication origin activation to ensure genome stability	8
Epigenetic Regulation of Tick Biology and Vectorial Capacity	8
Non-homologous chromosome pairing: sequence similarity or genetic control?	8
Conditional mutagenesis strategies in zebrafish	8
Driving to Safety: CRISPR-Based Genetic Approaches to Reducing Antibiotic Resistance	8
Consequences of trisomy syndromes – 21 and beyond	8
The gut microbiota links disease to human genome evolution	8
Catastrophic DNA replication in unscheduled tetraploid cells	8
Positive and Negative Regulation of DNA Replication Initiation	8
Unpacking chromatin remodelling in germ cells: implications for development and evolution	8
Neuromuscular disorders: finding the missing genetic diagnoses	8
A molecular toolkit for superorganisms	7
The influence of transposable elements on animal colouration	7
Conservation macrogenetics: harnessing genetic data to meet conservation commitments	7
Approaches and challenges in genome-wide circular RNA identification and quantification	7
Effective therapies for sickle cell disease: are we there yet?	7
Low-cost CRISPR diagnostics for resource-limited settings	7
Alternative Applications of Genotyping Array Data Using Multivariant Methods	7
lncRNAs in fertility: redefining the gene expression paradigm?	7
Progress and opportunities through use of genomics in animal production	7
RNA out of the mist	7
Chromoanagenesis in plants: triggers, mechanisms, and potential impact	7
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)	7
Genetics and epigenetics of rare hypersomnia	7
Challenges of Genetic Data Sharing in African Studies	7
Immunity and lifespan: answering long-standing questions with comparative genomics	6
Is it time to reassess variant annotation?	6
Using Genetics To Dissect SARS-CoV-2 Infection	6
The Curious Case of Avian Sex Determination	6