Journal of Controlled Release

Papers
(The TQCC of Journal of Controlled Release is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes433
Prediction of drug capturing by lipid emulsions in vivo for the treatment of a drug overdose343
Outside Back Cover330
Inside Back Cover311
Single-cell RNA transcriptome landscape of murine liver following systemic administration of mesoporous silica nanoparticles301
Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth287
Down-regulation of TNF-α via macrophage-targeted RNAi system for the treatment of acute inflammatory sepsis285
The colon targeting efficacies of mesalazine medications and their impacts on the gut microbiome271
In-situ-formed immunotherapeutic and hemostatic dual drug-loaded nanohydrogel for preventing postoperative recurrence of hepatocellular carcinoma268
Inside Back Cover265
Corrigendum to “Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch” [Journal of Controlled Release 372 (2024) 304–317]234
Outside Back Cover227
MSC-derived extracellular vesicles as nanotherapeutics for promoting aged liver regeneration224
Multifunctional nanoparticles potentiate in-situ tumor vaccines via reversing insufficient Photothermal therapy by disrupting tumor vasculature216
Delivery of DNA octahedra enhanced by focused ultrasound with microbubbles for glioma therapy212
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules201
A self-assembled graphene oxide adjuvant induces both enhanced humoral and cellular immune responses in influenza vaccine192
Cavitation-assisted sonothrombolysis by asymmetrical nanostars for accelerated thrombolysis188
An efficient (nano) silica - In glucan particles protein encapsulation approach for improved thermal stability181
Collagenase-modified polydopamine nanoparticles for safe and effective vitreolysis177
Autophagy-activating aluminum hydroxide nanovaccine for enhanced antigen presentation and anti-tumor immunity175
The pharmacokinetic profile of mitomycin C released from an injectable supramolecular hydrogel in a rodent model175
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs174
Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis173
Outside Front Cover170
Lanthanide nanocrystals-based direct triple-state energy converters for mitophagy and ferroptosis-induced antitumor immunoreaction169
Coordinated modulation of glucose metabolism and immunity via metal-drug nanovesicles for hepatocellular carcinoma therapy155
Metal-phenolic network-based polymeric nanocarriers facilitating antibody cytoplasmic delivery and anti-tumor effects to orthotopic breast tumors152
Multifunctional delivery strategies and nanoplatforms of SN-38 in cancer therapeutics147
Designing and modeling nanomedicines towards image-guided drug delivery in hematological malignancies143
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3141
Outside Front Cover: Yisheng Peng et al136
The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide for bone repair133
Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling132
Combinatorial physical methods for cellular therapy: Towards the future of cellular analysis?132
Dynamic versus static testing and in vivo mechanical performance of poly(glycolide-trimethylene carbonate-ε-caprolactone) delayed release implants131
Outside Back Cover130
Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors129
Integrative approaches to enhance adeno-associated viral gene delivery129
Mechanism exploration of intestinal mucus penetration of nano-Se: regulated by polysaccharides with different functional groups and molecular weights128
Alendronate-functionalized polymeric micelles target icaritin to bone for mitigating osteoporosis in a rat model128
Orthogonal upconversion nanocarriers for combined photodynamic therapy and precisely triggered gene silencing in combating keloids128
Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction128
In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer127
Oxygen-boosted fluorinated prodrug hybrid nanoassemblies for bidirectional amplification of breast cancer ferroptosis125
Identification of functional biomarkers for personalized nanomedicine in advanced breast cancer in vitro models123
White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin122
Impact of interferon-γ on the target cell tropism of nanoparticles122
Ferroptosis boosted oral cancer photodynamic therapy by carrier-free Sorafenib-Ce6 self-assembly nanoparticles117
Hypoxia-responsive oncolytic conjugate triggers type-II immunogenic cell death for enhanced photodynamic immunotherapy115
In vivo delivery of antioxidant enzymes with multi-functionalized lipid nanoparticles for sepsis therapy113
Thermoresponsive polymeric dexamethasone prodrug for arthritis pain112
Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation112
Full-cycle study on developing a novel structured micromixer and evaluating the nanoparticle products as mRNA delivery carriers111
Pickering emulsion-guided monomeric delivery of monophosphoryl lipid A for enhanced vaccination107
Unleashing the potential of cell biomimetic nanoparticles: Strategies and challenges in their design and fabrication for therapeutic applications103
Advance cardiac nanomedicine by targeting the pathophysiological characteristics of heart failure103
Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives101
Adaptable peptide-based therapeutics modulating tumor microenvironment for combinatorial radio-immunotherapy101
Transdermal carbon monoxide delivery100
Oral mucosal vaccination using integrated fiber microneedles99
An engineered dual function peptide to repair fractured bones99
Dasatinib and erianin co-loaded ion-responsive in-situ hydrogel for effective treatment of corneal neovascularization98
Hybrid nanopotentiators with dual cascade amplification for glioma combined interventional therapy98
Development of a thermostable oxytocin microneedle patch98
Combination of multivalent DR5 receptor clustering agonists and histone deacetylase inhibitors for treatment of colon cancer96
Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy96
Modified montmorillonite armed probiotics with enhanced on-site mucus-depleted intestinal colonization and H2S scavenging for colitis treatment96
Intraperitoneal drug delivery systems for peritoneal carcinomatosis: Bridging the gap between research and clinical implementation95
Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis95
Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment92
Mechanisms of uptake and transport of particulate formulations in the small intestine91
Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases91
Complement opsonization of nanoparticles: Differences between humans and preclinical species91
Extracellular vesicles for renal therapeutics: State of the art and future perspective91
Dual-stimulus phototherapeutic nanogel for triggering pyroptosis to promote cancer immunotherapy91
Self-assembly hydrogels of therapeutic agents for local drug delivery91
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence90
Enhanced browning of adipose tissue by mirabegron-microspheres88
Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy88
ZIF-8-modified hydrogel sequentially delivers angiogenic and osteogenic growth factors to accelerate vascularized bone regeneration88
Bioorthogonal conjugation and responsive nanocoating of probiotics for inflammatory bowel disease88
Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy88
Micellar paclitaxel boosts ICD and chemo-immunotherapy of metastatic triple negative breast cancer87
Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy87
Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug86
A smart cauliflower-like carrier for astaxanthin delivery to relieve colon inflammation86
Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis85
Nanoghosts: Mesenchymal Stem cells derived nanoparticles as a unique approach for cartilage regeneration84
Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?84
A next-generation STING agonist MSA-2: From mechanism to application84
Healing with precision: A multi-functional hydrogel-bioactive glass dressing boosts infected wound recovery and enhances neurogenesis in the wound bed84
Autophagy-modulating biomembrane nanostructures: A robust anticancer weapon by modulating the inner and outer cancer environment83
Melittin-incorporated nanomedicines for enhanced cancer immunotherapy83
Injectable nanocomposite hydrogel with cascade drug release for treatment of uveal melanoma83
Dendritic cell derived exosomes loaded neoantigens for personalized cancer immunotherapies82
Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice81
Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit “ferroptosis storm” and modulate immune targeting for acute kidney injury81
Inside Front Cover80
Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability80
Hybrid prodrug nanoassembly for hypoxia-triggered immunogenic chemotherapy and immune modulation80
Accelerated blood clearance of PEGylated nanoparticles induced by PEG-based pharmaceutical excipients80
Inside Back Cover79
Inside Back Cover79
Outside Front Cover79
Outside Front Cover78
Inside front cover: Yufan Qian et al78
Size matters: Altering antigen specific immune tolerance by tuning size of particles78
Tet1 peptide and zinc (II)-adenine multifunctional module functionalized polycations as efficient siRNA carriers for Parkinson's disease76
Strengthening scientific credibility in the face of misinformation and disinformation: Viable solutions76
Editorial Board76
Outside Back Cover: Yujie Wang et al75
Restoring tumor antigenicity activates the “bystander” T cell immune cycle75
Corrigendum to “Size-specific clonidine-loaded liposomes: Advancing melanoma microenvironment suppression with safety and precision” [Journal of Controlled Release, Volume 379, 10 March 2025, Pages 1274
Nanoparticle-mediated synergistic disruption of tumor innervation and redox homeostasis for potent antineoplastic therapy74
Photothermal-controlled NO-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis74
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine73
Modulation of GABAergic neurons in acute epilepsy using sonogenetics73
A polymer‑calcium phosphate nanocapsule for RNAi-induced oxidative stress and cascaded chemotherapy73
Corrigendum to “Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy” [Journal of Controlled Release 353 (2023) 447–461]72
Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension72
In situ formed reactive oxygen species-responsive dipyridamole prodrug hydrogel: Spatiotemporal drug delivery for chemoimmunotherapy72
Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy72
Thermal/ultrasound-triggered release of liposomes loaded with Ganoderma applanatum polysaccharide from microbubbles for enhanced tumour ablation72
Orthogonal and complementary measurements of properties of drug products containing nanomaterials72
Nebulized inhalation of LPAE-HDAC10 inhibits acetylation-mediated ROS/NF-κB pathway for silicosis treatment72
Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions72
Ion-paired moxifloxacin nanocrystal formulation improves treatment and prevention of ocular infection71
Substrate-free dissolving microneedles with barbed shape to increase adhesion and drug-delivery efficiency to skin71
Nano-engineered immune cells as “guided missiles” for cancer therapy71
An mRNA vaccine encoding proteasome-targeted antigen enhances CD8+ T cell immunity71
An “IgG-hitchhiking” approach for rapid tumor accumulation and clearance of photosensitizers71
Pre-mixing of omega-3 fatty acid-containing liposomes enhances the drug release rate and therapeutic efficacy of anticancer drugs loaded in liposomes70
Engineered bacterial extracellular vesicles for central nervous system diseases70
A trinity STING-activating nanoparticle harnesses cancer cell STING machinery for enhanced immunotherapy70
Interplay between mucus mobility and alveolar macrophage targeting of surface-modified liposomes70
Inorganic nanomaterials for drug delivery and therapeutic applications: Promise, pitfalls, and publication standards in journal of controlled release70
Programmed T cells infiltration into lung metastases with harnessing dendritic cells in cancer immunotherapies by catalytic antigen-capture sponges70
Unleashing the power of nucleic acid therapeutics through efficient cytosolic delivery69
Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates69
Inside Front Cover69
Promotion or inhibition of extracellular vesicle release: Emerging therapeutic opportunities69
Exploration of M2 macrophage membrane as a biotherapeutic agent and strong synergistic therapeutic effects in ischemic stroke69
Clinically relevant dosing of miR-145 micelles curbs atherosclerosis in vivo68
Multimodal nanoparticles co-delivering bevacizumab and dichloroacetate for dual targeting of neoangiogenesis and hyperglycolysis in glioblastoma treatment68
COG133 peptide-conjugated lipid nanoparticles sensitize medulloblastoma to radiation therapy in mice68
An engineered α1β1 integrin-mediated FcγRI signaling component to control enhanced CAR macrophage activation and phagocytosis67
Nanodrugs based on co-delivery strategies to combat cisplatin resistance67
Zeolite imidazolate framework-8 in bone regeneration: A systematic review67
Controlled release of manganese and magnesium ions by microsphere-encapsulated hydrogel enhances cancer immunotherapy67
Hyperglycemia-responsive nitric oxide-releasing biohybrid cryogels with cascade enzyme catalysis for enhanced healing of infected diabetic wounds66
Chemo-photothermal nanoplatform with diselenide as the key for ferroptosis in colorectal cancer66
AAV vectors applied to the treatment of CNS disorders: Clinical status and challenges66
Solvent electrospinning amorphous solid dispersions with high itraconazole, celecoxib, mebendazole and fenofibrate drug loading and release potential66
Acetyl-lysine human serum albumin nanoparticles activate CD44 receptors, with preferential uptake by cancer stem cells, leading to tumor eradication66
Enhancing protective immunity against SARS-CoV-2 with a self-amplifying RNA lipid nanoparticle vaccine66
Design of lipid-based formulations for oral delivery of a BASP1 peptide targeting MYC-dependent gastrointestinal cancer cells65
Nitroxide radical conjugated ovalbumin theranostic nanosystem for enhanced dendritic cell-based immunotherapy and T1 magnetic resonance imaging65
Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections65
Impact of injection sites on clinical pharmacokinetics of subcutaneously administered peptides and proteins65
Linoleic acid co-administration promotes oral delivery of exenatide-loaded butyrate-decorated nanocapsules65
Advocation and advancements of EPR effect theory in drug delivery science: A commentary65
Gastrointestinally absorbable lactoferrin-heparin conjugate with anti-angiogenic activity for treatment of brain tumor64
Molecular engineering of extracellular vesicles for drug delivery: Strategies, challenges, and perspectives64
Nanoadjuvants Actively targeting lymph node conduits and blocking tumor invasion in lymphatic vessels63
Endoplasmic reticulum-targeted biomimetic nanoparticles induce apoptosis and ferroptosis by regulating endoplasmic reticulum function in colon cancer63
Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route63
Programmable hierarchical hydrogel dressing for sequential release of growth factor and DNase to accelerate diabetic wound healing62
A macrophage membrane-coated mesoporous silica nanoplatform inhibiting adenosine A2AR via in situ oxygen supply for immunotherapy62
Co-delivery of drugs by adhesive transdermal patches equipped with dissolving microneedles for the treatment of rheumatoid arthritis62
Protein-based delivery systems for RNA delivery62
Transitioning from a lab-scale PLGA microparticle formulation to pilot-scale manufacturing62
A preparation method for mRNA-LNPs with improved properties62
Enhanced nose-to-brain delivery of siRNA using hyaluronan-enveloped nanomicelles for glioma therapy62
Microneedle patch-involved local therapy synergized with immune checkpoint inhibitor for pre- and post-operative cancer treatment61
Low-boiling-point perfluorocarbon nanodroplets for adaptable ultrasound-induced blood-brain barrier opening61
Dual-corn-derived nanofiber membrane for subconjunctival injury: Sequential release of dual-natural products for programmed anti-inflammation and anti-fibrosis61
Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer61
Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics61
Tyrosine kinase inhibitor prodrug-loaded liposomes for controlled release at tumor microenvironment60
Nano-chemical priming strategy to enhance TGF-β resistance and anti-tumor activity of natural killer cells60
Editorial Board60
Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice60
Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats60
Injectable thermosensitive hydrogel for local and controlled delivery of siRNA-STAT3 polyplexes to treat advanced-stage ovarian cancer60
A bionic “Trojan horse”-like gene delivery system hybridized with tumor and macrophage cell membrane for cancer therapy59
Platelet-mimicking supramolecular nanomedicine with precisely integrated prodrugs for cascade amplification of synergistic chemotherapy59
Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery59
Biomimetic-gasdermin-protein-expressing nanoplatform mediates tumor-specific pyroptosis for cancer immunotherapy59
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer59
Potent inhibition of MMP-9 by a novel sustained-release platform attenuates left ventricular remodeling following myocardial infarction59
Multifunctional nanocomposite hydrogel with dual-factor controlled release for stem cell recruitment, immunomodulation and bone remodeling59
Nanoscale coordination polymers enabling antioxidants inhibition for enhanced chemodynamic therapy59
All layers matter: Innovative three-dimensional epithelium-stroma-endothelium intestinal model for reliable permeability outcomes59
Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer58
Curcumin-release antibacterial dressings with antioxidation and anti-inflammatory function for diabetic wound healing and glucose monitoring58
Augmented the sensitivity of photothermal-ferroptosis therapy in triple-negative breast cancer through mitochondria-targeted nanoreactor58
Glioma-derived exosomes hijack the blood–brain barrier to facilitate nanocapsule delivery via LCN258
Reinforcing vascular normalization therapy with a bi-directional nano-system to achieve therapeutic-friendly tumor microenvironment58
Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy58
Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs58
Engineered vesicular cancer vaccines for immunosuppressive microenvironment reversion and in situ vaccine generation57
Prospects for hypoxia-based drug delivery platforms for the elimination of advanced metastatic tumors: From 3D modeling to clinical concepts57
Tiny tots for a big-league in wound repair: Tools for tissue regeneration by nanotechniques of today57
Treating colon cancers with a non-conventional yet strategic approach: An overview of various nanoparticulate systems57
Corrigendum to “Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery” [Journal of Controlled Release 57
High-density lipoprotein in Alzheimer's disease: From potential biomarkers to therapeutics57
Protein-based nanocages for vaccine development57
Efficient pulmonary fibrosis therapy via regulating macrophage polarization using respirable cryptotanshinone-loaded liposomal microparticles57
An antigen-capturing and lymph node-targeting nanoparticle for cancer immunotherapy57
Strategic aspects for the commercialization of nanomedicines57
Reversible opening of the blood-labyrinth barrier by low-pressure pulsed ultrasound and microbubbles for the treatment of inner ear diseases57
Levodopa-loaded nanoparticles for the treatment of Parkinson's disease56
Outside Front Cover56
Genetically engineered macrophages as living cell drug carriers for targeted cancer therapy56
In situ gelling systems for ocular drug delivery56
Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models55
Micelle-to-Gel: Thermosensitive intra-articular hydrogels for osteoarthritis management55
Editorial Board55
Construction of novel magnetic systems for cancer immunotherapy via cancer-immunity cycle circuits55
Corrigendum to “Ultrasound-responsive polymersomes capable of endosomal escape for efficient cancer therapy” [Journal of Controlled Release 322 (2020) 81–94]55
Inside Front Cover55
Determining topical product bioequivalence with stimulated Raman scattering microscopy55
DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics54
Shear force and cholesterol affinity responsive drug delivery system for treating inflammation and abnormal lipid metabolism in atherosclerosis54
Vaccine nanodiscs plus polyICLC elicit robust CD8+ T cell responses in mice and non-human primates54
Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product54
GOx-encapsulated iron-phenolic networks power catalytic cascade to eradicate bacterial biofilms54
Gemcitabine and miRNA34a mimic codelivery with magnetic nanoparticles enhanced anti-tumor effect against pancreatic cancer54
Intra-articular delivery of full-length antibodies through the use of an in situ forming depot54
Hyaluronidase-powered microneedles for significantly enhanced transdermal delivery efficiency54
Cardiosplenic axis-targeted immunomodulatory liposome for myocardial ischemia-reperfusion injury treatment54
Enhancing pancreatic cancer immunotherapy: Leveraging localized delivery strategies through the use of implantable devices and scaffolds53
In situ vaccine “seeds” for enhancing cancer immunotherapy by exploiting apoptosis-associated morphological changes53
Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis53
Engineered macrophages acting as a trigger to induce inflammation only in tumor tissues53
Fine-tuning of liposome integrity for differentiated transcytosis and enhanced antitumor efficacy53
Ligand-installed polymeric nanocarriers for combination chemotherapy of EGFR-positive ovarian cancer53
Smart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological features52
Influence of focused ultrasound on locoregional drug delivery to the brain: Potential implications for brain tumor therapy52
A glycopolymersome strategy for ‘drug-free’ treatment of diabetic nephropathy52
Self-adjuvanting polymeric nanovaccines enhance IFN production and cytotoxic T cell response52
Macrophage membrane-encapsulated miRNA nanodelivery system for the treatment of hemophilic arthritis52
Gastrointestinal-inert prebiotic micro-composites improve the growth and community diversity of mucosal-associated bacteria.51
Next generation therapeutics for retinal neurodegenerative diseases51
Manganese-induced Photothermal-Ferroptosis for Synergistic Tumor Therapy51
Current state of the art in peptide-based gene delivery51
Acid-base transformative HADLA micelles alleviate colitis by restoring adaptive immunity and gut microbiome51
The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency51
Aptamer-conjugated nano-liposome for immunogenic chemotherapy with reversal of immunosuppression51
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