Journal of Controlled Release

Article	Citations
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes	525
Prediction of drug capturing by lipid emulsions in vivo for the treatment of a drug overdose	363
Outside Back Cover	362
Inside Back Cover	317
Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy	267
In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer	265
Full-cycle study on developing a novel structured micromixer and evaluating the nanoparticle products as mRNA delivery carriers	251
Alendronate-functionalized polymeric micelles target icaritin to bone for mitigating osteoporosis in a rat model	246
Thermoresponsive polymeric dexamethasone prodrug for arthritis pain	245
Integrative approaches to enhance adeno-associated viral gene delivery	237
Pickering emulsion-guided monomeric delivery of monophosphoryl lipid A for enhanced vaccination	236
Inside Back Cover	234
Corrigendum to “Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch” [Journal of Controlled Release 372 (2024) 304–317]	218
Oxygen-boosted fluorinated prodrug hybrid nanoassemblies for bidirectional amplification of breast cancer ferroptosis	215
Autophagy-activating aluminum hydroxide nanovaccine for enhanced antigen presentation and anti-tumor immunity	197
An efficient (nano) silica - In glucan particles protein encapsulation approach for improved thermal stability	193
Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors	180
In-situ-formed immunotherapeutic and hemostatic dual drug-loaded nanohydrogel for preventing postoperative recurrence of hepatocellular carcinoma	178
Outside Back Cover	172
A self-assembled graphene oxide adjuvant induces both enhanced humoral and cellular immune responses in influenza vaccine	169
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3	167
Outside Front Cover: Yisheng Peng et al	162
Impact of interferon-γ on the target cell tropism of nanoparticles	160
Dual-stimulus phototherapeutic nanogel for triggering pyroptosis to promote cancer immunotherapy	159
The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide for bone repair	159

Combinatorial physical methods for cellular therapy: Towards the future of cellular analysis?	156
White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin	151
Multifunctional nanoparticles potentiate in-situ tumor vaccines via reversing insufficient Photothermal therapy by disrupting tumor vasculature	151
Mechanisms of uptake and transport of particulate formulations in the small intestine	145
Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy	143
Extracellular vesicles for renal therapeutics: State of the art and future perspective	141
Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis	140
Dynamic versus static testing and in vivo mechanical performance of poly(glycolide-trimethylene carbonate-ε-caprolactone) delayed release implants	136
Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases	136
Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy	131
Single-cell RNA transcriptome landscape of murine liver following systemic administration of mesoporous silica nanoparticles	129
Outside Back Cover	127
A next-generation STING agonist MSA-2: From mechanism to application	126
Hybrid nanopotentiators with dual cascade amplification for glioma combined interventional therapy	124
Combination of multivalent DR5 receptor clustering agonists and histone deacetylase inhibitors for treatment of colon cancer	122
Bioorthogonal conjugation and responsive nanocoating of probiotics for inflammatory bowel disease	121
Oral mucosal vaccination using integrated fiber microneedles	121
Autophagy-modulating biomembrane nanostructures: A robust anticancer weapon by modulating the inner and outer cancer environment	121
Identification of functional biomarkers for personalized nanomedicine in advanced breast cancer in vitro models	119
Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?	117
Tagged extracellular vesicles with the RBD of the viral spike protein for delivery of antiviral agents against SARS-COV-2 infection	117
An engineered dual function peptide to repair fractured bones	116
Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives	114
Down-regulation of TNF-α via macrophage-targeted RNAi system for the treatment of acute inflammatory sepsis	114
Enhanced browning of adipose tissue by mirabegron-microspheres	114
The colon targeting efficacies of mesalazine medications and their impacts on the gut microbiome	113
Advance cardiac nanomedicine by targeting the pathophysiological characteristics of heart failure	113
Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth	113
Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis	112
Dasatinib and erianin co-loaded ion-responsive in-situ hydrogel for effective treatment of corneal neovascularization	111
Nanoghosts: Mesenchymal Stem cells derived nanoparticles as a unique approach for cartilage regeneration	109
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence	108
Adaptable peptide-based therapeutics modulating tumor microenvironment for combinatorial radio-immunotherapy	107
Unleashing the potential of cell biomimetic nanoparticles: Strategies and challenges in their design and fabrication for therapeutic applications	106
Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation	102
Delivery of DNA octahedra enhanced by focused ultrasound with microbubbles for glioma therapy	101
ZIF-8-modified hydrogel sequentially delivers angiogenic and osteogenic growth factors to accelerate vascularized bone regeneration	100
Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy	100
Injectable nanocomposite hydrogel with cascade drug release for treatment of uveal melanoma	100
Micellar paclitaxel boosts ICD and chemo-immunotherapy of metastatic triple negative breast cancer	96
Development of a thermostable oxytocin microneedle patch	96
Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice	95
Transdermal carbon monoxide delivery	95
A smart cauliflower-like carrier for astaxanthin delivery to relieve colon inflammation	94
Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug	93
Intraperitoneal drug delivery systems for peritoneal carcinomatosis: Bridging the gap between research and clinical implementation	91
Ferroptosis boosted oral cancer photodynamic therapy by carrier-free Sorafenib-Ce6 self-assembly nanoparticles	91
Modified montmorillonite armed probiotics with enhanced on-site mucus-depleted intestinal colonization and H2S scavenging for colitis treatment	91
Orthogonal upconversion nanocarriers for combined photodynamic therapy and precisely triggered gene silencing in combating keloids	91
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules	91

Complement opsonization of nanoparticles: Differences between humans and preclinical species	89
Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling	88
Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis	87
Cavitation-assisted sonothrombolysis by asymmetrical nanostars for accelerated thrombolysis	87
Melittin-incorporated nanomedicines for enhanced cancer immunotherapy	86
Self-assembly hydrogels of therapeutic agents for local drug delivery	85
Hybrid prodrug nanoassembly for hypoxia-triggered immunogenic chemotherapy and immune modulation	85
Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit “ferroptosis storm” and modulate immune targeting for acute kidney injury	84
MSC-derived extracellular vesicles as nanotherapeutics for promoting aged liver regeneration	84
Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction	84
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs	84
Mechanism exploration of intestinal mucus penetration of nano-Se: regulated by polysaccharides with different functional groups and molecular weights	84
Accelerated blood clearance of PEGylated nanoparticles induced by PEG-based pharmaceutical excipients	83
Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability	82
Dendritic cell derived exosomes loaded neoantigens for personalized cancer immunotherapies	82
Healing with precision: A multi-functional hydrogel-bioactive glass dressing boosts infected wound recovery and enhances neurogenesis in the wound bed	81
Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment	81
Outside Front Cover	80
Inside Front Cover	80
Inside Back Cover	79
Inside Back Cover	79
Outside Front Cover	78
An “IgG-hitchhiking” approach for rapid tumor accumulation and clearance of photosensitizers	78
Size matters: Altering antigen specific immune tolerance by tuning size of particles	78
Inside front cover: Yufan Qian et al	78
Editorial Board	77
Impact of injection sites on clinical pharmacokinetics of subcutaneously administered peptides and proteins	77
Orthogonal and complementary measurements of properties of drug products containing nanomaterials	77
Pre-mixing of omega-3 fatty acid-containing liposomes enhances the drug release rate and therapeutic efficacy of anticancer drugs loaded in liposomes	76
Exploration of M2 macrophage membrane as a biotherapeutic agent and strong synergistic therapeutic effects in ischemic stroke	75
Substrate-free dissolving microneedles with barbed shape to increase adhesion and drug-delivery efficiency to skin	75
A macrophage membrane-coated mesoporous silica nanoplatform inhibiting adenosine A2AR via in situ oxygen supply for immunotherapy	75
Thermal/ultrasound-triggered release of liposomes loaded with Ganoderma applanatum polysaccharide from microbubbles for enhanced tumour ablation	75
Nanoadjuvants Actively targeting lymph node conduits and blocking tumor invasion in lymphatic vessels	74
Strengthening scientific credibility in the face of misinformation and disinformation: Viable solutions	74
Enhancing protective immunity against SARS-CoV-2 with a self-amplifying RNA lipid nanoparticle vaccine	74
Nanoparticle-mediated synergistic disruption of tumor innervation and redox homeostasis for potent antineoplastic therapy	74
Tet1 peptide and zinc (II)-adenine multifunctional module functionalized polycations as efficient siRNA carriers for Parkinson's disease	73
A polymer‑calcium phosphate nanocapsule for RNAi-induced oxidative stress and cascaded chemotherapy	73
Modulation of GABAergic neurons in acute epilepsy using sonogenetics	73
Low-boiling-point perfluorocarbon nanodroplets for adaptable ultrasound-induced blood-brain barrier opening	72
Restoring tumor antigenicity activates the “bystander” T cell immune cycle	71
Programmed T cells infiltration into lung metastases with harnessing dendritic cells in cancer immunotherapies by catalytic antigen-capture sponges	71
Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer	70
Corrigendum to “Size-specific clonidine-loaded liposomes: Advancing melanoma microenvironment suppression with safety and precision” [Journal of Controlled Release, Volume 379, 10 March 2025, Pages 12	70
Outside Back Cover: Yujie Wang et al	70
Chemo-photothermal nanoplatform with diselenide as the key for ferroptosis in colorectal cancer	69
Advocation and advancements of EPR effect theory in drug delivery science: A commentary	69
Solvent electrospinning amorphous solid dispersions with high itraconazole, celecoxib, mebendazole and fenofibrate drug loading and release potential	68
Engineering a sustained release vaccine with a pathogen-mimicking manner for robust and durable immune responses	68
Electrospun fibers for vaginal administration of tenofovir disoproxil fumarate and emtricitabine in the context of topical pre-exposure prophylaxis	68
Photothermal-controlled NO-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis	67
Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions	67
Nitroxide radical conjugated ovalbumin theranostic nanosystem for enhanced dendritic cell-based immunotherapy and T1 magnetic resonance imaging	67
Ion-paired moxifloxacin nanocrystal formulation improves treatment and prevention of ocular infection	67
Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy	67
An mRNA vaccine encoding proteasome-targeted antigen enhances CD8+ T cell immunity	67
Nano-engineered immune cells as “guided missiles” for cancer therapy	66
Nano-chemical priming strategy to enhance TGF-β resistance and anti-tumor activity of natural killer cells	66
Interplay between mucus mobility and alveolar macrophage targeting of surface-modified liposomes	66
Corrigendum to “Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy” [Journal of Controlled Release 353 (2023) 447–461]	66
Controlled release of triamcinolone from an episcleral micro film delivery system for open-globe eye injuries and proliferative vitreoretinopathy	66
Nanodrugs based on co-delivery strategies to combat cisplatin resistance	66
Hyperglycemia-responsive nitric oxide-releasing biohybrid cryogels with cascade enzyme catalysis for enhanced healing of infected diabetic wounds	65
In situ formed reactive oxygen species-responsive dipyridamole prodrug hydrogel: Spatiotemporal drug delivery for chemoimmunotherapy	65
Controlled release of manganese and magnesium ions by microsphere-encapsulated hydrogel enhances cancer immunotherapy	65
Enhanced nose-to-brain delivery of siRNA using hyaluronan-enveloped nanomicelles for glioma therapy	64
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity	64
Transitioning from a lab-scale PLGA microparticle formulation to pilot-scale manufacturing	64
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine	64
Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension	64
Engineered bacterial extracellular vesicles for central nervous system diseases	64
A preparation method for mRNA-LNPs with improved properties	64
Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics	64
Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections	64
Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice	63
AAV vectors applied to the treatment of CNS disorders: Clinical status and challenges	63
Endoplasmic reticulum-targeted biomimetic nanoparticles induce apoptosis and ferroptosis by regulating endoplasmic reticulum function in colon cancer	63
Gastrointestinally absorbable lactoferrin-heparin conjugate with anti-angiogenic activity for treatment of brain tumor	63
Zeolite imidazolate framework-8 in bone regeneration: A systematic review	63

A trinity STING-activating nanoparticle harnesses cancer cell STING machinery for enhanced immunotherapy	63
Promotion or inhibition of extracellular vesicle release: Emerging therapeutic opportunities	62
Dual-corn-derived nanofiber membrane for subconjunctival injury: Sequential release of dual-natural products for programmed anti-inflammation and anti-fibrosis	62
Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route	62
Microneedle patch-involved local therapy synergized with immune checkpoint inhibitor for pre- and post-operative cancer treatment	62
Biomimetic-gasdermin-protein-expressing nanoplatform mediates tumor-specific pyroptosis for cancer immunotherapy	61
Nebulized inhalation of LPAE-HDAC10 inhibits acetylation-mediated ROS/NF-κB pathway for silicosis treatment	61
Protein-based delivery systems for RNA delivery	61
Strategic aspects for the commercialization of nanomedicines	61
An engineered α1β1 integrin-mediated FcγRI signaling component to control enhanced CAR macrophage activation and phagocytosis	61
Co-delivery of drugs by adhesive transdermal patches equipped with dissolving microneedles for the treatment of rheumatoid arthritis	61
A glycopolymersome strategy for ‘drug-free’ treatment of diabetic nephropathy	61
Potent inhibition of MMP-9 by a novel sustained-release platform attenuates left ventricular remodeling following myocardial infarction	61
Ferrocene-containing polymersome nanoreactors for synergistically amplified tumor-specific chemodynamic therapy	61
Editorial Board	60
A bionic “Trojan horse”-like gene delivery system hybridized with tumor and macrophage cell membrane for cancer therapy	60
A bifunctional nanocomplex with remineralizing and antibacterial activities to interrupt dental caries	60
A novel peptide hydrogel of metal ion clusters for accelerating bone defect regeneration	60
Reversible opening of the blood-labyrinth barrier by low-pressure pulsed ultrasound and microbubbles for the treatment of inner ear diseases	59
Ligand-installed polymeric nanocarriers for combination chemotherapy of EGFR-positive ovarian cancer	59
Macrophage membrane-encapsulated miRNA nanodelivery system for the treatment of hemophilic arthritis	59
Construction of novel magnetic systems for cancer immunotherapy via cancer-immunity cycle circuits	58
Self-adjuvanting polymeric nanovaccines enhance IFN production and cytotoxic T cell response	58
Next generation therapeutics for retinal neurodegenerative diseases	58
Prospects for hypoxia-based drug delivery platforms for the elimination of advanced metastatic tumors: From 3D modeling to clinical concepts	58
Modulating albumin-mediated transport of peptide-drug conjugates for antigen-specific Treg induction	58
Intra-articular delivery of full-length antibodies through the use of an in situ forming depot	57
In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review	57
Glioma-derived exosomes hijack the blood–brain barrier to facilitate nanocapsule delivery via LCN2	57
Current state of the art in peptide-based gene delivery	57
Reinforcing vascular normalization therapy with a bi-directional nano-system to achieve therapeutic-friendly tumor microenvironment	57
Levodopa-loaded nanoparticles for the treatment of Parkinson's disease	57
Gastrointestinal-inert prebiotic micro-composites improve the growth and community diversity of mucosal-associated bacteria.	56
Locally delivered hydrogels with controlled release of nanoscale exosomes promote cardiac repair after myocardial infarction	56
Tyrosine kinase inhibitor prodrug-loaded liposomes for controlled release at tumor microenvironment	55
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer	55
Shear force and cholesterol affinity responsive drug delivery system for treating inflammation and abnormal lipid metabolism in atherosclerosis	55
Micelle-to-Gel: Thermosensitive intra-articular hydrogels for osteoarthritis management	54
Augmented the sensitivity of photothermal-ferroptosis therapy in triple-negative breast cancer through mitochondria-targeted nanoreactor	54
Engineered macrophages acting as a trigger to induce inflammation only in tumor tissues	54
GOx-encapsulated iron-phenolic networks power catalytic cascade to eradicate bacterial biofilms	54
Bioengineered nanotechnology for nucleic acid delivery	54
Inside Front Cover	53
Outside Back Cover	53
Tiny tots for a big-league in wound repair: Tools for tissue regeneration by nanotechniques of today	53
Enhancing pancreatic cancer immunotherapy: Leveraging localized delivery strategies through the use of implantable devices and scaffolds	53
LncRNA-edited biomimetic nanovaccines combined with anti-TIM-3 for augmented immune checkpoint blockade immunotherapy	53
Inside Back Cover	53
Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats	53
Editorial Board	53
Outside Front Cover	53
Smart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological features	53
In situ gelling systems for ocular drug delivery	53
Acid-base transformative HADLA micelles alleviate colitis by restoring adaptive immunity and gut microbiome	52
Determining topical product bioequivalence with stimulated Raman scattering microscopy	52
Nanoscale coordination polymers enabling antioxidants inhibition for enhanced chemodynamic therapy	52
All layers matter: Innovative three-dimensional epithelium-stroma-endothelium intestinal model for reliable permeability outcomes	52
Fine-tuning of liposome integrity for differentiated transcytosis and enhanced antitumor efficacy	52
Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs	52
Corrigendum to “Ultrasound-responsive polymersomes capable of endosomal escape for efficient cancer therapy” [Journal of Controlled Release 322 (2020) 81–94]	52
Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models	52
Platelet-mimicking supramolecular nanomedicine with precisely integrated prodrugs for cascade amplification of synergistic chemotherapy	51
Genetically engineered macrophages as living cell drug carriers for targeted cancer therapy	51
Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product	51
High-density lipoprotein in Alzheimer's disease: From potential biomarkers to therapeutics	51
Red blood cell-mimicking liposomes loading curcumin promote diabetic wound healing	51
An antigen-capturing and lymph node-targeting nanoparticle for cancer immunotherapy	51
Combating cisplatin-resistant lung cancer using a coiled-coil lipopeptides modified membrane fused drug delivery system	51
Protein-based nanocages for vaccine development	51
Microenvironment responsive charge-switchable nanoparticles act on biofilm eradication and virulence inhibition for chronic lung infection treatment	51
In situ vaccine “seeds” for enhancing cancer immunotherapy by exploiting apoptosis-associated morphological changes	51
Vaccine nanodiscs plus polyICLC elicit robust CD8+ T cell responses in mice and non-human primates	51
Curcumin-release antibacterial dressings with antioxidation and anti-inflammatory function for diabetic wound healing and glucose monitoring	51
Gemcitabine and miRNA34a mimic codelivery with magnetic nanoparticles enhanced anti-tumor effect against pancreatic cancer	50
Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration	50
Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy	50
Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis	50
Nanoceria, the versatile nanoparticles: Promising biomedical applications	50
DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics	50
M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization	50
Manganese-induced Photothermal-Ferroptosis for Synergistic Tumor Therapy	50
Influence of focused ultrasound on locoregional drug delivery to the brain: Potential implications for brain tumor therapy	50
Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review	49
The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency	49
Hyaluronidase-powered microneedles for significantly enhanced transdermal delivery efficiency	49
Recent advances in Bio-conjugated nanocarriers for crossing the Blood-Brain Barrier in (pre-)clinical studies with an emphasis on vesicles	49
Efficient pulmonary fibrosis therapy via regulating macrophage polarization using respirable cryptotanshinone-loaded liposomal microparticles	49
Stimuli-responsive and biomimetic delivery systems for sepsis and related complications	49
A nanodrug combining CD47 and sonodynamic therapy efficiently inhibits osteosarcoma deterioration	49
Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II	49
Cell microencapsulation technologies for sustained drug delivery: Latest advances in efficacy and biosafety	49
Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer	49
Modulation of release and pharmacokinetics from nanoscale lipid prodrugs of dexamethasone with variable linkage chemistry	48
Backmatter	48
Editorial Board	48