Journal of Controlled Release

Article	Citations
Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions	429
Electrospinning for drug delivery applications: A review	347
Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment	331
Photothermal therapy	304
The dawn of mRNA vaccines: The COVID-19 case	274
Polymeric micelles in cancer therapy: State of the art	271
Chitosan hydrogels for sustained drug delivery	242
Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies	234
Delivering the power of nanomedicine to patients today	219
Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance	203
Nanoparticles in sustainable agriculture: An emerging opportunity	196
Vat photopolymerization 3D printing for advanced drug delivery and medical device applications	186
Magnetic iron oxide nanoparticles for imaging, targeting and treatment of primary and metastatic tumors of the brain	179
Advances and limitations of drug delivery systems formulated as eye drops	177
Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies	171
Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges	159
Bacterial outer membrane vesicles as a platform for biomedical applications: An update	159
Controlled release fertilizer: A review on developments, applications and potential in agriculture	158
Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake	155
In vivo gene delivery mediated by non-viral vectors for cancer therapy	153
Challenges in the development and establishment of exosome-based drug delivery systems	152
Chronic wounds: Current status, available strategies and emerging therapeutic solutions	150
Charge-reversal biodegradable MSNs for tumor synergetic chemo/photothermal and visualized therapy	148
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity	148
The role of natural polymers in bone tissue engineering	147

A review of nanotechnology-based approaches for breast cancer and triple-negative breast cancer	146
Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing	145
Mechanism of a long-term controlled drug release system based on simple blended electrospun fibers	144
Stimuli-responsive In situ gelling system for nose-to-brain drug delivery	137
Macrophage-mimic shape changeable nanomedicine retained in tumor for multimodal therapy of breast cancer	135
Agarose-based biomaterials for advanced drug delivery	134
Advances in biodegradable and injectable hydrogels for biomedical applications	134
Evolution of drug delivery systems: From 1950 to 2020 and beyond	133
Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting	132
Advanced drug delivery applications of layered double hydroxide	131
Recent advances in polymeric transdermal drug delivery systems	130
Zero-order drug delivery: State of the art and future prospects	129
Photo-responsive supramolecular hyaluronic acid hydrogels for accelerated wound healing	129
Microneedles for painless transdermal immunotherapeutic applications	128
Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders	127
Ultrasound and microbubble mediated therapeutic delivery: Underlying mechanisms and future outlook	126
Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy	125
Functionalized silk fibroin nanofibers as drug carriers: Advantages and challenges	124
Recent trends in organic coating based on biopolymers and biomass for controlled and slow release fertilizers	123
Cell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy	123
Aerogels in drug delivery: From design to application	121
Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapy	120
Metal-doped and hybrid carbon dots: A comprehensive review on their synthesis and biomedical applications	120
Nanoparticle–hydrogel superstructures for biomedical applications	118
Nanomedicines accessible in the market for clinical interventions	118
Hyaluronic acid and albumin based nanoparticles for drug delivery	117
A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing	113
Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation	112
Rational design of a minimalist nanoplatform to maximize immunotherapeutic efficacy: Four birds with one stone	111
Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy	110
Stimuli-responsive nano-assemblies for remotely controlled drug delivery	109
Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems	107
Recent advances in nanotechnology-based drug delivery systems for the kidney	107
Non-viral vectors for RNA delivery	104
Polyester based polymeric nano and microparticles for pharmaceutical purposes: A review on formulation approaches	103
Preparation and application of pH-responsive drug delivery systems	102
Hypromellose – A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery	100
Solid lipid nanoparticles for hydrophilic drugs	100
Bioresponsive drug delivery systems for the treatment of inflammatory diseases	97
Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection	95
Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy	94
Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery	94
Customizing nano-chitosan for sustainable drug delivery	94
Hydrogel-forming microneedle arrays as a therapeutic option for transdermal esketamine delivery	93
Progress in the design and development of “fast-dissolving” electrospun nanofibers based drug delivery systems - A systematic review	93
Thiolated polymeric hydrogels for biomedical application: Cross-linking mechanisms	92
Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis	91
Carrier-free nanodrugs for safe and effective cancer treatment	91
Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics	91
Dissolving microneedles: Applications and growing therapeutic potential	91

M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization	90
Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines	90
Machine learning predicts 3D printing performance of over 900 drug delivery systems	90
Serum protein-based nanoparticles for cancer diagnosis and treatment	90
Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic	89
Magnetic nanoparticles for cancer theranostics: Advances and prospects	89
Bacteria and bacterial derivatives as drug carriers for cancer therapy	87
Overcoming skin barriers through advanced transdermal drug delivery approaches	87
Recent advances in nanoparticle-based photothermal therapy for breast cancer	87
Heterojunction engineered bioactive chlorella for cascade promoted cancer therapy	86
Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer	86
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs	84
Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges	84
pH-sensitive MOF integrated with glucose oxidase for glucose-responsive insulin delivery	83
Synthesis and functionalization of hyperbranched polymers for targeted drug delivery	83
Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy	82
Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines	82
Novel and revisited approaches in nanoparticle systems for buccal drug delivery	82
In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review	80
Recent advances and remaining barriers to producing novel formulations of fungicides for safe and sustainable agriculture	80
Recent advances of redox-responsive nanoplatforms for tumor theranostics	80
Macrophage-based nanotherapeutic strategies in ulcerative colitis	80
Ultrasound-responsive polymersomes capable of endosomal escape for efficient cancer therapy	79
Current trends in smart mesoporous silica-based nanovehicles for photoactivated cancer therapy	78
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products	78
Current developments in nanotechnology for improved cancer treatment, focusing on tumor hypoxia	78
Recent advances in colon drug delivery systems	77
Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy	76
Strategies to improve the EPR effect: A mechanistic perspective and clinical translation	76
Inflammation-targeting polymeric nanoparticles deliver sparfloxacin and tacrolimus for combating acute lung sepsis	76
Graphene nanoribbons: A promising nanomaterial for biomedical applications	76
Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: A review	76
Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules	75
Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury	75
Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury	75
Engineered extracellular vesicles and their mimetics for cancer immunotherapy	74
Co-delivery of silybin and paclitaxel by dextran-based nanoparticles for effective anti-tumor treatment through chemotherapy sensitization and microenvironment modulation	74
Nanoparticles-encapsulated polymeric microneedles for transdermal drug delivery	74
Intravitreal hydrogels for sustained release of therapeutic proteins	74
Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy	74
ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease	73
Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment	73
Computational pharmaceutics - A new paradigm of drug delivery	73
Magnetic-responsive hydrogels: From strategic design to biomedical applications	73
Recent trends, challenges and future outlook of transdermal drug delivery systems for rheumatoid arthritis therapy	72
Platelet-armored nanoplatform to harmonize janus-faced IFN-γ against tumor recurrence and metastasis	72
pH-Responsive charge switchable PEGylated ε-poly-l-lysine polymeric nanoparticles-assisted combination therapy for improving breast cancer treatment	72
Tendon tissue engineering: Cells, growth factors, scaffolds and production techniques	71
Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy	71
Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications	71
Ionic liquid-mediated delivery of insulin to buccal mucosa	71
Dimeric prodrug-based nanomedicines for cancer therapy	71
Recent progress in design and preparation of glucose-responsive insulin delivery systems	70
Therapeutic nanoemulsions in ophthalmic drug administration: Concept in formulations and characterization techniques for ocular drug delivery	70
PCL-PEG copolymer based injectable thermosensitive hydrogels	70
Tumor microenvironment-activated self-recognizing nanodrug through directly tailored assembly of small-molecules for targeted synergistic chemotherapy	69
Targeting cancer-associated fibroblasts by dual-responsive lipid-albumin nanoparticles to enhance drug perfusion for pancreatic tumor therapy	68
Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment	68
Cell membrane cloaked nanomedicines for bio-imaging and immunotherapy of cancer: Improved pharmacokinetics, cell internalization and anticancer efficacy	68
Acetal containing polymers as pH-responsive nano-drug delivery systems	67
Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement	67
Cyclodextrin based natural nanostructured carbohydrate polymers as effective non-viral siRNA delivery systems for cancer gene therapy	67
Tumor cell membrane enveloped aluminum phosphate nanoparticles for enhanced cancer vaccination	66
Multifunctional graphene oxide nanoparticles for drug delivery in cancer	66
Extracellular vesicles for tumor targeting delivery based on five features principle	66
Conducting polymer hydrogels for electrically responsive drug delivery	65
Construction of microneedle-assisted co-delivery platform and its combining photodynamic/immunotherapy	65
Exosome-based photoacoustic imaging guided photodynamic and immunotherapy for the treatment of pancreatic cancer	65
Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles	65
High resolution photopolymer for 3D printing of personalised microneedle for transdermal delivery of anti-wrinkle small peptide	65
Nucleic acid-based drug delivery strategies	65
Engineered exosome as targeted lncRNA MEG3 delivery vehicles for osteosarcoma therapy	64
Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic	64
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment	64
Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy	64
On-demand fully customizable drug tablets via 3D printing technology for personalized medicine	64
Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives	64
Maintaining manganese in tumor to activate cGAS-STING pathway evokes a robust abscopal anti-tumor effect	64
Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020	64
RGD engineered dendrimer nanotherapeutic as an emerging targeted approach in cancer therapy	63

One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility	63
CaCO3 crystals as versatile carriers for controlled delivery of antimicrobials	63
Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions	63
Development of nanoparticle-delivery systems for antiviral agents: A review	63
Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells	62
Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer	62
Preservation of biomaterials and cells by freeze-drying: Change of paradigm	62
Melanin-loaded CpG DNA hydrogel for modulation of tumor immune microenvironment	62
Antibody and antibody fragments for cancer immunotherapy	62
Nanoformulation strategies for improving intestinal permeability of drugs: A more precise look at permeability assessment methods and pharmacokinetic properties changes	62
Hyperbranched poly(β-amino ester) based polyplex nanopaticles for delivery of CRISPR/Cas9 system and treatment of HPV infection associated cervical cancer	61
Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression	61
Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches	61
Albumin-biomineralized nanoparticles to synergize phototherapy and immunotherapy against melanoma	61
Doxorubicin-loaded composite nanogels for cancer treatment	61
Dual delivery of stem cells and insulin-like growth factor-1 in coacervate-embedded composite hydrogels for enhanced cartilage regeneration in osteochondral defects	61
Oral delivery of micro/nanoparticulate systems based on natural polysaccharides for intestinal diseases therapy: Challenges, advances and future perspectives	61
Recent advances in microneedles-based drug delivery device in the diagnosis and treatment of cancer	61
Ultrasound-responsive neurotrophic factor-loaded microbubble- liposome complex: Preclinical investigation for Parkinson's disease treatment	61
TRAIL-expressing cell membrane nanovesicles as an anti-inflammatory platform for rheumatoid arthritis therapy	61
Stealth nanoparticles in oncology: Facing the PEG dilemma	60
Recent advances and prospects of hyaluronan as a multifunctional therapeutic system	60
Nanoscale drug delivery systems for controllable drug behaviors by multi-stage barrier penetration	60
Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment	60
Protein encapsulation by electrospinning and electrospraying	60
Bile acid transporter-mediated oral drug delivery	60
Controlled release of odontogenic exosomes from a biodegradable vehicle mediates dentinogenesis as a novel biomimetic pulp capping therapy	59
Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo	59
Bacterial anti-microbial peptides and nano-sized drug delivery systems: The state of the art toward improved bacteriocins	59
Accelerating the development of novel technologies and tools for the subcutaneous delivery of biotherapeutics	59
Pharmaceutical strategies for endoplasmic reticulum-targeting and their prospects of application	59
The reversal of chemotherapy-induced multidrug resistance by nanomedicine for cancer therapy	58
Nanoparticle delivery improves the pharmacokinetic properties of cyclic dinucleotide STING agonists to open a therapeutic window for intravenous administration	57
Nanoceria, the versatile nanoparticles: Promising biomedical applications	57
Self-assembled polymeric vesicles: Focus on polymersomes in cancer treatment	57
Advances in drug delivery technology for the treatment of glioblastoma multiforme	57
Nasal administration of nanoencapsulated geraniol/ursodeoxycholic acid conjugate: Towards a new approach for the management of Parkinson's disease	57
Target delivering paclitaxel by ferritin heavy chain nanocages for glioma treatment	57
Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy	57
Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: Breakthroughs and bottlenecks	57
Topical delivery of siRNA into skin using ionic liquids	56
Cell surface GRP78: An emerging imaging marker and therapeutic target for cancer	56
Exosome membrane-modified M2 macrophages targeted nanomedicine: Treatment for allergic asthma	56
Lymphatic targeting by albumin-hitchhiking: Applications and optimisation	56
Nanozyme-mediated cascade reaction based on metal-organic framework for synergetic chemo-photodynamic tumor therapy	56
Blockade of CTLA-4 increases anti-tumor response inducing potential of dendritic cell vaccine	56
Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehicles	56
Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications	56
Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes	56
Selenium and dopamine-crosslinked hyaluronic acid hydrogel for chemophotothermal cancer therapy	56
Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain	56
A tunable and injectable local drug delivery system for personalized periodontal application	55
Self-assembly of oxidation-responsive polyethylene glycol-paclitaxel prodrug for cancer chemotherapy	55
Oral delivery of sorafenib through spontaneous formation of ionic liquid nanocomplexes	55
A pH-responsive silica–metal–organic framework hybrid nanoparticle for the delivery of hydrophilic drugs, nucleic acids, and CRISPR-Cas9 genome-editing machineries	55
Evasion of the accelerated blood clearance phenomenon by polysarcosine coating of liposomes	55
A superstable homogeneous lipiodol-ICG formulation for locoregional hepatocellular carcinoma treatment	55
Tailoring guanidyl-rich polymers for efficient cytosolic protein delivery	55
Formulation composition, manufacturing process, and characterization of poly(lactide-co-glycolide) microparticles	55
Metabolic reprogramming mediated PD-L1 depression and hypoxia reversion to reactivate tumor therapy	54
Ultrasound in tumor immunotherapy: Current status and future developments	54
Immune cells as tumor drug delivery vehicles	54
A metal-organic framework-based immunomodulatory nanoplatform for anti-atherosclerosis treatment	54
Lipid nanoparticles loaded with ribonucleoprotein–oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition	54
Tumor microenvironment-induced structure changing drug/gene delivery system for overcoming delivery-associated challenges	54
Ferrocene-containing polymersome nanoreactors for synergistically amplified tumor-specific chemodynamic therapy	54
Hypoxia-sensitive supramolecular nanogels for the cytosolic delivery of ribonuclease A as a breast cancer therapeutic	54
Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines	54
Oral delivery of bacteria: Basic principles and biomedical applications	53
Tropism-facilitated delivery of CRISPR/Cas9 system with chimeric antigen receptor-extracellular vesicles against B-cell malignancies	53
Bactericidal coating to prevent early and delayed implant-related infections	53
Delivery of thymoquinone through hyaluronic acid-decorated mixed Pluronic® nanoparticles to attenuate angiogenesis and metastasis of triple-negative breast cancer	53
Paper-based microfluidics for rapid diagnostics and drug delivery	53
Controlled drug delivery with nanoassemblies of redox-responsive prodrug and polyprodrug amphiphiles	52
Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems	52
pH-sensitive multi-drug liposomes targeting folate receptor β for efficient treatment of non-small cell lung cancer	52
Gold nanoparticle-mediated bubbles in cancer nanotechnology	52
Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections	52
Opening of endothelial cell–cell contacts due to sonoporation	52
Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo	52
The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering	51
A conductive cell-delivery construct as a bioengineered patch that can improve electrical propagation and synchronize cardiomyocyte contraction for heart repair	51
Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery	51
Recent progresses in exosome-based systems for targeted drug delivery to the brain	51
Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases	51
Self-assembly of amphiphilic phospholipid peptide dendrimer-based nanovectors for effective delivery of siRNA therapeutics in prostate cancer therapy	51
Redox-responsive polyethyleneimine/tetrahedron DNA/doxorubicin nanocomplexes for deep cell/tissue penetration to overcome multidrug resistance	51
Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system	51
Ocular drug delivery to the anterior segment using nanocarriers: A mucoadhesive/mucopenetrative perspective	51
Iron nanoparticles augmented chemodynamic effect by alternative magnetic field for wound disinfection and healing	51
A novel kinetic model to describe the ultra-fast triggered release of thermosensitive liposomal drug delivery systems	51
Self-assembling peptide hydrogels for the stabilization and sustained release of active Chondroitinase ABC in vitro and in spinal cord injuries	51
Magnetic particle targeting for diagnosis and therapy of lung cancers	51
Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation	51
DP7-C-modified liposomes enhance immune responses and the antitumor effect of a neoantigen-based mRNA vaccine	51