Journal of Controlled Release

Papers
(The median citation count of Journal of Controlled Release is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
Prediction of drug capturing by lipid emulsions in vivo for the treatment of a drug overdose458
Outside Back Cover357
Single-cell RNA transcriptome landscape of murine liver following systemic administration of mesoporous silica nanoparticles350
Inside Back Cover329
Corrigendum to “Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch” [Journal of Controlled Release 372 (2024) 304–317]313
Outside Back Cover308
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3307
Outside Front Cover: Yisheng Peng et al283
Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling277
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules271
Dynamic versus static testing and in vivo mechanical performance of poly(glycolide-trimethylene carbonate-ε-caprolactone) delayed release implants241
Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis241
Outside Back Cover234
Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors228
Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction220
Orthogonal upconversion nanocarriers for combined photodynamic therapy and precisely triggered gene silencing in combating keloids217
Combination of multivalent DR5 receptor clustering agonists and histone deacetylase inhibitors for treatment of colon cancer203
Transdermal carbon monoxide delivery194
Complement opsonization of nanoparticles: Differences between humans and preclinical species187
Full-cycle study on developing a novel structured micromixer and evaluating the nanoparticle products as mRNA delivery carriers181
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes181
Multifunctional nanoparticles potentiate in-situ tumor vaccines via reversing insufficient Photothermal therapy by disrupting tumor vasculature181
Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy180
Pickering emulsion-guided monomeric delivery of monophosphoryl lipid A for enhanced vaccination177
Hybrid prodrug nanoassembly for hypoxia-triggered immunogenic chemotherapy and immune modulation176
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence176
MSC-derived extracellular vesicles as nanotherapeutics for promoting aged liver regeneration175
The pharmacokinetic profile of mitomycin C released from an injectable supramolecular hydrogel in a rodent model155
Collagenase-modified polydopamine nanoparticles for safe and effective vitreolysis151
Lanthanide nanocrystals-based direct triple-state energy converters for mitophagy and ferroptosis-induced antitumor immunoreaction150
Designing and modeling nanomedicines towards image-guided drug delivery in hematological malignancies148
Coordinated modulation of glucose metabolism and immunity via metal-drug nanovesicles for hepatocellular carcinoma therapy145
Outside Front Cover141
Hypoxia-responsive oncolytic conjugate triggers type-II immunogenic cell death for enhanced photodynamic immunotherapy137
Advance cardiac nanomedicine by targeting the pathophysiological characteristics of heart failure136
Oral mucosal vaccination using integrated fiber microneedles136
Autophagy-activating aluminum hydroxide nanovaccine for enhanced antigen presentation and anti-tumor immunity136
Alendronate-functionalized polymeric micelles target icaritin to bone for mitigating osteoporosis in a rat model134
Oxygen-boosted fluorinated prodrug hybrid nanoassemblies for bidirectional amplification of breast cancer ferroptosis133
Autophagy-modulating biomembrane nanostructures: A robust anticancer weapon by modulating the inner and outer cancer environment132
The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide for bone repair131
Optimized bacterial delivery approaches for precision immunotherapy in breast cancer models131
Nanoparticle-based methionine and AICAR delivery elicits a robust antitumor immune response130
A next-generation STING agonist MSA-2: From mechanism to application127
White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin127
Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?126
Self-assembly hydrogels of therapeutic agents for local drug delivery125
Cavitation-assisted sonothrombolysis by asymmetrical nanostars for accelerated thrombolysis122
An efficient (nano) silica - In glucan particles protein encapsulation approach for improved thermal stability117
Impact of interferon-γ on the target cell tropism of nanoparticles116
Multifunctional delivery strategies and nanoplatforms of SN-38 in cancer therapeutics114
Integrative approaches to enhance adeno-associated viral gene delivery114
Healing with precision: A multi-functional hydrogel-bioactive glass dressing boosts infected wound recovery and enhances neurogenesis in the wound bed112
Identification of functional biomarkers for personalized nanomedicine in advanced breast cancer in vitro models110
Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy105
A self-assembled graphene oxide adjuvant induces both enhanced humoral and cellular immune responses in influenza vaccine104
Extracellular vesicles for renal therapeutics: State of the art and future perspective104
Melittin-incorporated nanomedicines for enhanced cancer immunotherapy103
Intraperitoneal drug delivery systems for peritoneal carcinomatosis: Bridging the gap between research and clinical implementation102
Hybrid nanopotentiators with dual cascade amplification for glioma combined interventional therapy102
An engineered dual function peptide to repair fractured bones102
Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth101
Thermoresponsive polymeric dexamethasone prodrug for arthritis pain101
Metal-phenolic network-based polymeric nanocarriers facilitating antibody cytoplasmic delivery and anti-tumor effects to orthotopic breast tumors100
Injectable nanocomposite hydrogel with cascade drug release for treatment of uveal melanoma100
Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy98
Combinatorial physical methods for cellular therapy: Towards the future of cellular analysis?97
Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis96
ZIF-8-modified hydrogel sequentially delivers angiogenic and osteogenic growth factors to accelerate vascularized bone regeneration95
Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug94
Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit “ferroptosis storm” and modulate immune targeting for acute kidney injury93
Dasatinib and erianin co-loaded ion-responsive in-situ hydrogel for effective treatment of corneal neovascularization93
Micellar paclitaxel boosts ICD and chemo-immunotherapy of metastatic triple negative breast cancer93
A smart cauliflower-like carrier for astaxanthin delivery to relieve colon inflammation93
Adaptable peptide-based therapeutics modulating tumor microenvironment for combinatorial radio-immunotherapy93
Enhanced browning of adipose tissue by mirabegron-microspheres93
Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability92
Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice91
Mechanism exploration of intestinal mucus penetration of nano-Se: regulated by polysaccharides with different functional groups and molecular weights91
Nanoghosts: Mesenchymal Stem cells derived nanoparticles as a unique approach for cartilage regeneration91
In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer90
Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy89
Delivery of DNA octahedra enhanced by focused ultrasound with microbubbles for glioma therapy89
Modified montmorillonite armed probiotics with enhanced on-site mucus-depleted intestinal colonization and H2S scavenging for colitis treatment89
Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases89
Development of a thermostable oxytocin microneedle patch88
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs87
Mechanisms of uptake and transport of particulate formulations in the small intestine86
The colon targeting efficacies of mesalazine medications and their impacts on the gut microbiome86
In vivo delivery of antioxidant enzymes with multi-functionalized lipid nanoparticles for sepsis therapy86
Bioorthogonal conjugation and responsive nanocoating of probiotics for inflammatory bowel disease86
Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment85
Unleashing the potential of cell biomimetic nanoparticles: Strategies and challenges in their design and fabrication for therapeutic applications85
Dual-stimulus phototherapeutic nanogel for triggering pyroptosis to promote cancer immunotherapy85
Ferroptosis boosted oral cancer photodynamic therapy by carrier-free Sorafenib-Ce6 self-assembly nanoparticles84
Dendritic cell derived exosomes loaded neoantigens for personalized cancer immunotherapies84
In-situ-formed immunotherapeutic and hemostatic dual drug-loaded nanohydrogel for preventing postoperative recurrence of hepatocellular carcinoma83
Accelerated blood clearance of PEGylated nanoparticles induced by PEG-based pharmaceutical excipients83
Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives82
Outside Front Cover82
Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis82
Inside Front Cover82
Inside Back Cover81
Inside Back Cover80
Outside Front Cover80
Editorial Board79
Tet1 peptide and zinc (II)-adenine multifunctional module functionalized polycations as efficient siRNA carriers for Parkinson's disease79
Size matters: Altering antigen specific immune tolerance by tuning size of particles79
Strengthening scientific credibility in the face of misinformation and disinformation: Viable solutions79
Inside front cover: Yufan Qian et al79
Restoring tumor antigenicity activates the “bystander” T cell immune cycle78
Outside Back Cover: Yujie Wang et al78
Photothermal-controlled NO-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis77
A polymer‑calcium phosphate nanocapsule for RNAi-induced oxidative stress and cascaded chemotherapy77
Nanoparticle-mediated synergistic disruption of tumor innervation and redox homeostasis for potent antineoplastic therapy77
Corrigendum to “Size-specific clonidine-loaded liposomes: Advancing melanoma microenvironment suppression with safety and precision” [Journal of Controlled Release, Volume 379, 10 March 2025, Pages 1277
Modulation of GABAergic neurons in acute epilepsy using sonogenetics76
Gastrointestinally absorbable lactoferrin-heparin conjugate with anti-angiogenic activity for treatment of brain tumor75
Enhancing protective immunity against SARS-CoV-2 with a self-amplifying RNA lipid nanoparticle vaccine75
Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension75
Pre-mixing of omega-3 fatty acid-containing liposomes enhances the drug release rate and therapeutic efficacy of anticancer drugs loaded in liposomes75
Thermal/ultrasound-triggered release of liposomes loaded with Ganoderma applanatum polysaccharide from microbubbles for enhanced tumour ablation74
Endoplasmic reticulum-targeted biomimetic nanoparticles induce apoptosis and ferroptosis by regulating endoplasmic reticulum function in colon cancer74
Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer74
Controlled release of manganese and magnesium ions by microsphere-encapsulated hydrogel enhances cancer immunotherapy74
Injectable thermosensitive hydrogel for local and controlled delivery of siRNA-STAT3 polyplexes to treat advanced-stage ovarian cancer74
Corrigendum to “Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy” [Journal of Controlled Release 353 (2023) 447–461]73
Nano-engineered immune cells as “guided missiles” for cancer therapy73
Exploration of M2 macrophage membrane as a biotherapeutic agent and strong synergistic therapeutic effects in ischemic stroke73
Dual-corn-derived nanofiber membrane for subconjunctival injury: Sequential release of dual-natural products for programmed anti-inflammation and anti-fibrosis73
Microneedle patch-involved local therapy synergized with immune checkpoint inhibitor for pre- and post-operative cancer treatment73
Programmable hierarchical hydrogel dressing for sequential release of growth factor and DNase to accelerate diabetic wound healing73
Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy73
A preparation method for mRNA-LNPs with improved properties73
Solvent electrospinning amorphous solid dispersions with high itraconazole, celecoxib, mebendazole and fenofibrate drug loading and release potential72
Orthogonal and complementary measurements of properties of drug products containing nanomaterials72
Chemo-photothermal nanoplatform with diselenide as the key for ferroptosis in colorectal cancer71
Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections71
Unleashing the power of nucleic acid therapeutics through efficient cytosolic delivery70
Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route70
Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates70
Inside Front Cover70
Nanoadjuvants Actively targeting lymph node conduits and blocking tumor invasion in lymphatic vessels70
Multimodal nanoparticles co-delivering bevacizumab and dichloroacetate for dual targeting of neoangiogenesis and hyperglycolysis in glioblastoma treatment70
A macrophage membrane-coated mesoporous silica nanoplatform inhibiting adenosine A2AR via in situ oxygen supply for immunotherapy70
Acetyl-lysine human serum albumin nanoparticles activate CD44 receptors, with preferential uptake by cancer stem cells, leading to tumor eradication69
Clinically relevant dosing of miR-145 micelles curbs atherosclerosis in vivo69
Design of lipid-based formulations for oral delivery of a BASP1 peptide targeting MYC-dependent gastrointestinal cancer cells69
COG133 peptide-conjugated lipid nanoparticles sensitize medulloblastoma to radiation therapy in mice69
Linoleic acid co-administration promotes oral delivery of exenatide-loaded butyrate-decorated nanocapsules69
Inorganic nanomaterials for drug delivery and therapeutic applications: Promise, pitfalls, and publication standards in Journal of Controlled Release68
Nitroxide radical conjugated ovalbumin theranostic nanosystem for enhanced dendritic cell-based immunotherapy and T1 magnetic resonance imaging67
In situ formed reactive oxygen species-responsive dipyridamole prodrug hydrogel: Spatiotemporal drug delivery for chemoimmunotherapy67
Nano-chemical priming strategy to enhance TGF-β resistance and anti-tumor activity of natural killer cells67
An “IgG-hitchhiking” approach for rapid tumor accumulation and clearance of photosensitizers66
A trinity STING-activating nanoparticle harnesses cancer cell STING machinery for enhanced immunotherapy66
Ion-paired moxifloxacin nanocrystal formulation improves treatment and prevention of ocular infection66
Programmed T cells infiltration into lung metastases with harnessing dendritic cells in cancer immunotherapies by catalytic antigen-capture sponges66
An mRNA vaccine encoding proteasome-targeted antigen enhances CD8+ T cell immunity66
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine65
Transitioning from a lab-scale PLGA microparticle formulation to pilot-scale manufacturing65
Promotion or inhibition of extracellular vesicle release: Emerging therapeutic opportunities65
AAV vectors applied to the treatment of CNS disorders: Clinical status and challenges65
Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice65
Zeolite imidazolate framework-8 in bone regeneration: A systematic review65
An engineered α1β1 integrin-mediated FcγRI signaling component to control enhanced CAR macrophage activation and phagocytosis65
Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions65
Hyperglycemia-responsive nitric oxide-releasing biohybrid cryogels with cascade enzyme catalysis for enhanced healing of infected diabetic wounds65
Substrate-free dissolving microneedles with barbed shape to increase adhesion and drug-delivery efficiency to skin65
Protein-based delivery systems for RNA delivery65
Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics64
Interplay between mucus mobility and alveolar macrophage targeting of surface-modified liposomes64
Nebulized inhalation of LPAE-HDAC10 inhibits acetylation-mediated ROS/NF-κB pathway for silicosis treatment63
Low-boiling-point perfluorocarbon nanodroplets for adaptable ultrasound-induced blood-brain barrier opening63
Nanodrugs based on co-delivery strategies to combat cisplatin resistance63
Advocation and advancements of EPR effect theory in drug delivery science: A commentary62
Enhanced nose-to-brain delivery of siRNA using hyaluronan-enveloped nanomicelles for glioma therapy62
Co-delivery of drugs by adhesive transdermal patches equipped with dissolving microneedles for the treatment of rheumatoid arthritis62
Engineered bacterial extracellular vesicles for central nervous system diseases62
Potent inhibition of MMP-9 by a novel sustained-release platform attenuates left ventricular remodeling following myocardial infarction61
Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats61
Outside Front Cover61
Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models61
Editorial Board61
Acid-base transformative HADLA micelles alleviate colitis by restoring adaptive immunity and gut microbiome61
Inside Front Cover61
Corrigendum to “Ultrasound-responsive polymersomes capable of endosomal escape for efficient cancer therapy” [Journal of Controlled Release 322 (2020) 81–94]61
Gemcitabine and miRNA34a mimic codelivery with magnetic nanoparticles enhanced anti-tumor effect against pancreatic cancer61
Tyrosine kinase inhibitor prodrug-loaded liposomes for controlled release at tumor microenvironment61
Combating cisplatin-resistant lung cancer using a coiled-coil lipopeptides modified membrane fused drug delivery system61
Editorial Board61
In situ vaccine “seeds” for enhancing cancer immunotherapy by exploiting apoptosis-associated morphological changes61
Engineered macrophages acting as a trigger to induce inflammation only in tumor tissues60
Construction of novel magnetic systems for cancer immunotherapy via cancer-immunity cycle circuits60
DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics60
GOx-encapsulated iron-phenolic networks power catalytic cascade to eradicate bacterial biofilms60
Intra-articular delivery of full-length antibodies through the use of an in situ forming depot59
Prospects for hypoxia-based drug delivery platforms for the elimination of advanced metastatic tumors: From 3D modeling to clinical concepts59
Tiny tots for a big-league in wound repair: Tools for tissue regeneration by nanotechniques of today59
Fine-tuning of liposome integrity for differentiated transcytosis and enhanced antitumor efficacy59
Influence of focused ultrasound on locoregional drug delivery to the brain: Potential implications for brain tumor therapy59
Platelet-mimicking supramolecular nanomedicine with precisely integrated prodrugs for cascade amplification of synergistic chemotherapy59
Ligand-installed polymeric nanocarriers for combination chemotherapy of EGFR-positive ovarian cancer59
Self-adjuvanting polymeric nanovaccines enhance IFN production and cytotoxic T cell response59
Curcumin-release antibacterial dressings with antioxidation and anti-inflammatory function for diabetic wound healing and glucose monitoring59
Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product58
Reinforcing vascular normalization therapy with a bi-directional nano-system to achieve therapeutic-friendly tumor microenvironment58
Nanoscale coordination polymers enabling antioxidants inhibition for enhanced chemodynamic therapy58
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer58
Nanoceria, the versatile nanoparticles: Promising biomedical applications58
The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency58
Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy58
Locally delivered hydrogels with controlled release of nanoscale exosomes promote cardiac repair after myocardial infarction58
Determining topical product bioequivalence with stimulated Raman scattering microscopy57
Current state of the art in peptide-based gene delivery57
Smart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological features57
High-density lipoprotein in Alzheimer's disease: From potential biomarkers to therapeutics57
Glioma-derived exosomes hijack the blood–brain barrier to facilitate nanocapsule delivery via LCN256
An antigen-capturing and lymph node-targeting nanoparticle for cancer immunotherapy56
In situ gelling systems for ocular drug delivery56
Shear force and cholesterol affinity responsive drug delivery system for treating inflammation and abnormal lipid metabolism in atherosclerosis56
A novel peptide hydrogel of metal ion clusters for accelerating bone defect regeneration55
Hyaluronidase-powered microneedles for significantly enhanced transdermal delivery efficiency55
Splenic B cell-targeting lipid nanoparticles for safe and effective mRNA vaccine delivery55
Gastrointestinal-inert prebiotic micro-composites improve the growth and community diversity of mucosal-associated bacteria.55
Levodopa-loaded nanoparticles for the treatment of Parkinson's disease55
Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer55
Bioengineered nanotechnology for nucleic acid delivery54
Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis54
Protein-based nanocages for vaccine development54
A bionic “Trojan horse”-like gene delivery system hybridized with tumor and macrophage cell membrane for cancer therapy54
Stimuli-responsive and biomimetic delivery systems for sepsis and related complications54
Genetically engineered macrophages as living cell drug carriers for targeted cancer therapy54
A glycopolymersome strategy for ‘drug-free’ treatment of diabetic nephropathy53
All layers matter: Innovative three-dimensional epithelium-stroma-endothelium intestinal model for reliable permeability outcomes53
Next generation therapeutics for retinal neurodegenerative diseases53
Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II53
A bifunctional nanocomplex with remineralizing and antibacterial activities to interrupt dental caries53
A nanodrug combining CD47 and sonodynamic therapy efficiently inhibits osteosarcoma deterioration53
Micelle-to-Gel: Thermosensitive intra-articular hydrogels for osteoarthritis management52
Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery52
Cardiosplenic axis-targeted immunomodulatory liposome for myocardial ischemia-reperfusion injury treatment52
Enhancing pancreatic cancer immunotherapy: Leveraging localized delivery strategies through the use of implantable devices and scaffolds52
Multifunctional nanocomposite hydrogel with dual-factor controlled release for stem cell recruitment, immunomodulation and bone remodeling52
Microenvironment responsive charge-switchable nanoparticles act on biofilm eradication and virulence inhibition for chronic lung infection treatment52
M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization52
Corrigendum to “Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery” [Journal of Controlled Release 51
Strategic aspects for the commercialization of nanomedicines51
Biomimetic-gasdermin-protein-expressing nanoplatform mediates tumor-specific pyroptosis for cancer immunotherapy51
Modulating albumin-mediated transport of peptide-drug conjugates for antigen-specific Treg induction51
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