Journal of Controlled Release

Article	Citations
Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions	561
Electrospinning for drug delivery applications: A review	421
Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment	420
Polymeric micelles in cancer therapy: State of the art	332
The dawn of mRNA vaccines: The COVID-19 case	313
Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies	309
Nanoparticles in sustainable agriculture: An emerging opportunity	234
Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake	226
Vat photopolymerization 3D printing for advanced drug delivery and medical device applications	223
Controlled release fertilizer: A review on developments, applications and potential in agriculture	221
Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges	196
Evolution of drug delivery systems: From 1950 to 2020 and beyond	195
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity	192
Chronic wounds: Current status, available strategies and emerging therapeutic solutions	188
Challenges in the development and establishment of exosome-based drug delivery systems	187
Zero-order drug delivery: State of the art and future prospects	179
The role of natural polymers in bone tissue engineering	179
Recent advances in polymeric transdermal drug delivery systems	176
A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing	166
Advanced drug delivery applications of layered double hydroxide	163
Preparation and application of pH-responsive drug delivery systems	163
Stimuli-responsive In situ gelling system for nose-to-brain drug delivery	161
Hyaluronic acid and albumin based nanoparticles for drug delivery	159
Charge-reversal biodegradable MSNs for tumor synergetic chemo/photothermal and visualized therapy	157
Non-viral vectors for RNA delivery	157

Cell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy	154
Advances in biodegradable and injectable hydrogels for biomedical applications	150
Recent trends in organic coating based on biopolymers and biomass for controlled and slow release fertilizers	149
Aerogels in drug delivery: From design to application	149
Metal-doped and hybrid carbon dots: A comprehensive review on their synthesis and biomedical applications	145
Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery	143
Microneedles for painless transdermal immunotherapeutic applications	142
Dissolving microneedles: Applications and growing therapeutic potential	141
Overcoming skin barriers through advanced transdermal drug delivery approaches	139
Nanomedicines accessible in the market for clinical interventions	137
Recent advances in nanoparticle-based photothermal therapy for breast cancer	133
Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation	127
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs	126
Solid lipid nanoparticles for hydrophilic drugs	125
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products	125
Rational design of a minimalist nanoplatform to maximize immunotherapeutic efficacy: Four birds with one stone	124
Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines	121
Strategies to improve the EPR effect: A mechanistic perspective and clinical translation	119
Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy	119
M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization	117
Bioresponsive drug delivery systems for the treatment of inflammatory diseases	117
Carrier-free nanodrugs for safe and effective cancer treatment	116
Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges	116
Customizing nano-chitosan for sustainable drug delivery	116
Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics	115
Serum protein-based nanoparticles for cancer diagnosis and treatment	111
In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review	108
Thiolated polymeric hydrogels for biomedical application: Cross-linking mechanisms	108
Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines	108
Magnetic nanoparticles for cancer theranostics: Advances and prospects	108
Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic	106
Machine learning predicts 3D printing performance of over 900 drug delivery systems	106
Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy	106
Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications	104
PCL-PEG copolymer based injectable thermosensitive hydrogels	103
Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis	102
Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer	100
Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy	100
Computational pharmaceutics - A new paradigm of drug delivery	99
Magnetic-responsive hydrogels: From strategic design to biomedical applications	98
Recent advances of redox-responsive nanoplatforms for tumor theranostics	97
Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: A review	97
Current trends in smart mesoporous silica-based nanovehicles for photoactivated cancer therapy	97
Heterojunction engineered bioactive chlorella for cascade promoted cancer therapy	96
Stealth nanoparticles in oncology: Facing the PEG dilemma	96
Recent advances in colon drug delivery systems	94
Multifunctional graphene oxide nanoparticles for drug delivery in cancer	93
Tendon tissue engineering: Cells, growth factors, scaffolds and production techniques	92
Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment	92
ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease	91

Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches	90
Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives	90
Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment	90
Recent trends, challenges and future outlook of transdermal drug delivery systems for rheumatoid arthritis therapy	89
Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020	89
Engineered exosome as targeted lncRNA MEG3 delivery vehicles for osteosarcoma therapy	88
Therapeutic nanoemulsions in ophthalmic drug administration: Concept in formulations and characterization techniques for ocular drug delivery	88
Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement	88
Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles	86
Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions	85
Preservation of biomaterials and cells by freeze-drying: Change of paradigm	84
Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells	84
Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications	84
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment	83
Acetal containing polymers as pH-responsive nano-drug delivery systems	83
Oral delivery of micro/nanoparticulate systems based on natural polysaccharides for intestinal diseases therapy: Challenges, advances and future perspectives	82
Maintaining manganese in tumor to activate cGAS-STING pathway evokes a robust abscopal anti-tumor effect	81
Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases	81
Platelet-armored nanoplatform to harmonize janus-faced IFN-γ against tumor recurrence and metastasis	81
Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes	81
Bile acid transporter-mediated oral drug delivery	81
Doxorubicin-loaded composite nanogels for cancer treatment	81
Ionic liquid-mediated delivery of insulin to buccal mucosa	81
Engineered extracellular vesicles and their mimetics for cancer immunotherapy	80
Cell membrane cloaked nanomedicines for bio-imaging and immunotherapy of cancer: Improved pharmacokinetics, cell internalization and anticancer efficacy	80
Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer	80
Exosome-based photoacoustic imaging guided photodynamic and immunotherapy for the treatment of pancreatic cancer	79
RGD engineered dendrimer nanotherapeutic as an emerging targeted approach in cancer therapy	79
Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems	78
The reversal of chemotherapy-induced multidrug resistance by nanomedicine for cancer therapy	78
Nanoceria, the versatile nanoparticles: Promising biomedical applications	78
Conducting polymer hydrogels for electrically responsive drug delivery	78
Recent advances in microneedles-based drug delivery device in the diagnosis and treatment of cancer	78
CaCO3 crystals as versatile carriers for controlled delivery of antimicrobials	78
Current perspectives and trend of nanomedicine in cancer: A review and bibliometric analysis	77
Cyclodextrin based natural nanostructured carbohydrate polymers as effective non-viral siRNA delivery systems for cancer gene therapy	76
Antibody and antibody fragments for cancer immunotherapy	75
High resolution photopolymer for 3D printing of personalised microneedle for transdermal delivery of anti-wrinkle small peptide	75
Protein encapsulation by electrospinning and electrospraying	73
Self-assembled polymeric vesicles: Focus on polymersomes in cancer treatment	73
Nanoparticle delivery improves the pharmacokinetic properties of cyclic dinucleotide STING agonists to open a therapeutic window for intravenous administration	72
Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system	71
Recent advances and prospects of hyaluronan as a multifunctional therapeutic system	71
Nanoscale drug delivery systems for controllable drug behaviors by multi-stage barrier penetration	70
Pharmaceutical strategies for endoplasmic reticulum-targeting and their prospects of application	70
Development of nanoparticle-delivery systems for antiviral agents: A review	70
Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo	69
Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines	69
Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehicles	69
mRNA vaccines for COVID-19 and diverse diseases	69
Metabolic reprogramming mediated PD-L1 depression and hypoxia reversion to reactivate tumor therapy	69
Biotherapeutic-loaded injectable hydrogels as a synergistic strategy to support myocardial repair after myocardial infarction	69
Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy	68
Lymphatic targeting by albumin-hitchhiking: Applications and optimisation	68
Aptamer-conjugated nano-liposome for immunogenic chemotherapy with reversal of immunosuppression	68
Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)	68
Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain	68
Advances in drug delivery technology for the treatment of glioblastoma multiforme	67
Formulation composition, manufacturing process, and characterization of poly(lactide-co-glycolide) microparticles	67
Dual delivery of stem cells and insulin-like growth factor-1 in coacervate-embedded composite hydrogels for enhanced cartilage regeneration in osteochondral defects	67
A metal-organic framework-based immunomodulatory nanoplatform for anti-atherosclerosis treatment	66
Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: Breakthroughs and bottlenecks	66
Immune cells as tumor drug delivery vehicles	66
Microneedles for gene and drug delivery in skin cancer therapy	64
Melanin-loaded CpG DNA hydrogel for modulation of tumor immune microenvironment	64
Vaccine-like nanomedicine for cancer immunotherapy	64
Ferrocene-containing polymersome nanoreactors for synergistically amplified tumor-specific chemodynamic therapy	63
Oral delivery of bacteria: Basic principles and biomedical applications	63
Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics	63
Exosome membrane-modified M2 macrophages targeted nanomedicine: Treatment for allergic asthma	63
Applications and challenges of ultra-small particle size nanoparticles in tumor therapy	62
Targeted nanomedicine in cisplatin-based cancer therapeutics	62
Magnetic particle targeting for diagnosis and therapy of lung cancers	62
Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections	62
Lipid nanoparticles loaded with ribonucleoprotein–oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition	62
Scaffolds for drug delivery and tissue engineering: The role of genetics	61
Recent progresses in exosome-based systems for targeted drug delivery to the brain	61
The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering	61
Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes	61
DP7-C-modified liposomes enhance immune responses and the antitumor effect of a neoantigen-based mRNA vaccine	61

Nanozyme-mediated cascade reaction based on metal-organic framework for synergetic chemo-photodynamic tumor therapy	61
Bioinspired and biomimetic micro- and nanostructures in biomedicine	61
Cell surface GRP78: An emerging imaging marker and therapeutic target for cancer	60
Synthesis of block copolymers used in polymersome fabrication: Application in drug delivery	60
Triple negative breast cancer and non-small cell lung cancer: Clinical challenges and nano-formulation approaches	60
Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation	60
Micellar paclitaxel boosts ICD and chemo-immunotherapy of metastatic triple negative breast cancer	60
Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos	59
Nanoparticles incorporated in nanofibers using electrospinning: A novel nano-in-nano delivery system	59
Redox-responsive polyethyleneimine/tetrahedron DNA/doxorubicin nanocomplexes for deep cell/tissue penetration to overcome multidrug resistance	59
Photothermal antibacterial materials to promote wound healing	59
Anticancer DOX delivery system based on CNTs: Functionalization, targeting and novel technologies	59
pH-sensitive multi-drug liposomes targeting folate receptor β for efficient treatment of non-small cell lung cancer	58
Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain	58
Photosensitive drug delivery systems for cancer therapy: Mechanisms and applications	58
Advanced approaches for improving bioavailability and controlled release of anthocyanins	58
Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface	58
Advancements in cell membrane camouflaged nanoparticles: A bioinspired platform for cancer therapy	58
Nanoporous materials for pesticide formulation and delivery in the agricultural sector	58
Self-assembling peptide hydrogels for the stabilization and sustained release of active Chondroitinase ABC in vitro and in spinal cord injuries	57
Electrospraying as a novel method of particle engineering for drug delivery vehicles	57
Glycosylation of PAMAM dendrimers significantly improves tumor macrophage targeting and specificity in glioblastoma	57
Mucoadhesive carriers for oral drug delivery	57
Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease	57
Ocular drug delivery to the anterior segment using nanocarriers: A mucoadhesive/mucopenetrative perspective	57
Rational design of metal-organic frameworks to deliver methotrexate for targeted rheumatoid arthritis therapy	56
Temozolomide nano enabled medicine: promises made by the nanocarriers in glioblastoma therapy	56
Cutting-edge progress and challenges in stimuli responsive hydrogel microenvironment for success in tissue engineering today	56
Hyaluronic acid coated bilirubin nanoparticles attenuate ischemia reperfusion-induced acute kidney injury	56
Osteoconductive hybrid hyaluronic acid hydrogel patch for effective bone formation	55
Promotion or inhibition of extracellular vesicle release: Emerging therapeutic opportunities	55
Chitosan on the surface of nanoparticles for enhanced drug delivery: A comprehensive review	55
Dissolvable polymer microneedles for drug delivery and diagnostics	55
A smart cauliflower-like carrier for astaxanthin delivery to relieve colon inflammation	55
MoS2 based nanomaterials: Advanced antibacterial agents for future	55
Bioactive glass: A multifunctional delivery system	55
Controlled drug delivery systems in eradicating bacterial biofilm-associated infections	55
Drug-loaded biomaterials for orthopedic applications: A review	54
Tissue-specific engineering: 3D bioprinting in regenerative medicine	54
Ionic liquids as a useful tool for tailoring active pharmaceutical ingredients	54
Effect of micro- and nanoparticle shape on biological processes	54
Triggered azobenzene-based prodrugs and drug delivery systems	54
Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review	54
Transport of PEGylated-PLA nanoparticles across a blood brain barrier model, entry into neuronal cells and in vivo brain bioavailability	54
An Overview on Gold Nanorods as Versatile Nanoparticles in Cancer Therapy	54
Ivermectin: an award-winning drug with expected antiviral activity against COVID-19	54
Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions	53
Nano-delivery systems focused on tumor microenvironment regulation and biomimetic strategies for treatment of breast cancer metastasis	53
Cavitation-modulated inflammatory response following focused ultrasound blood-brain barrier opening	53
Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer	53
Challenges and opportunities in the development of complex generic long-acting injectable drug products	53
Novel lipid combination for delivery of plasmid DNA to immune cells in the spleen	53
Apoptotic bodies for advanced drug delivery and therapy	53
Cancer therapy based on extracellular vesicles as drug delivery vehicles	53
Gold nanoparticle-mediated bubbles in cancer nanotechnology	53
Glioma diagnosis and therapy: Current challenges and nanomaterial-based solutions	53
RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery	52
Fabricating scalable, personalized wound dressings with customizable drug loadings via 3D printing	52
Engineering approaches for effective therapeutic applications based on extracellular vesicles	52
Trends in advanced oral drug delivery system for curcumin: A systematic review	52
Heme Oxygenase-1 targeting exosomes for temozolomide resistant glioblastoma synergistic therapy	51
Stem cell membrane, stem cell-derived exosomes and hybrid stem cell camouflaged nanoparticles: A promising biomimetic nanoplatforms for cancer theranostics	51
Nanomaterials targeting tumor associated macrophages for cancer immunotherapy	51
Hair follicle targeting with curcumin nanocrystals: Influence of the formulation properties on the penetration efficacy	51
Microneedle-mediated vascular endothelial growth factor delivery promotes angiogenesis and functional recovery after stroke	51
An oxidative stress-responsive electrospun polyester membrane capable of releasing anti-bacterial and anti-inflammatory agents for postoperative anti-adhesion	51
Engineered albumin-functionalized nanoparticles for improved FcRn binding enhance oral delivery of insulin	51
X-ray-responsive polypeptide nanogel for concurrent chemoradiotherapy	51
Dendritic cell derived exosomes loaded neoantigens for personalized cancer immunotherapies	51
Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction	50
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury	50
Artemether and lumefantrine dissolving microneedle patches with improved pharmacokinetic performance and antimalarial efficacy in mice infected with Plasmodium yoelii	50
In situ-gelling starch nanoparticle (SNP)/O-carboxymethyl chitosan (CMCh) nanoparticle network hydrogels for the intranasal delivery of an antipsychotic peptide	50
Current state of the art in peptide-based gene delivery	50
Low dose shikonin and anthracyclines coloaded liposomes induce robust immunogenetic cell death for synergistic chemo-immunotherapy	50
Molybdenum-based hetero-nanocomposites for cancer therapy, diagnosis and biosensing application: Current advancement and future breakthroughs	50
Precise oral delivery systems for probiotics: A review	50
Advanced mesoporous silica nanocarriers in cancer theranostics and gene editing applications	49
In vivo targeted delivery of nucleic acids and CRISPR genome editors enabled by GSH-responsive silica nanoparticles	49
Novel concept of exosome-like liposomes for the treatment of Alzheimer's disease	49
In vivo blockade of mononuclear phagocyte system with solid nanoparticles: Efficiency and affecting factors	49
Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells	49
Alendronate-functionalized hypoxia-responsive polymeric micelles for targeted therapy of bone metastatic prostate cancer	49
Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease	49
BBB-crossing adeno-associated virus vector: An excellent gene delivery tool for CNS disease treatment	49
Controlled-release of free bacteriophage nanoparticles from 3D-plotted hydrogel fibrous structure as potential antibacterial wound dressing	49
Nano co-delivery of Plumbagin and Dihydrotanshinone I reverses immunosuppressive TME of liver cancer	49
Intelligent poly(l-histidine)-based nanovehicles for controlled drug delivery	49
Exosomes and biomimetic nanovesicles-mediated anti-glioblastoma therapy: A head-to-head comparison	48
Not only in silico drug discovery: Molecular modeling towards in silico drug delivery formulations	48
Self-assembled polymeric micelle as a novel mRNA delivery carrier	48
Advanced nanomedicine approaches applied for treatment of skin carcinoma	48
Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery	48
Oxidative stress-amplified nanomedicine for intensified ferroptosis-apoptosis combined tumor therapy	48
Anticancer drug-loaded mesenchymal stem cells for targeted cancer therapy	48