OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Controlled Release is 86. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes	433
Prediction of drug capturing by lipid emulsions in vivo for the treatment of a drug overdose	343
Outside Back Cover	330
Inside Back Cover	311
Single-cell RNA transcriptome landscape of murine liver following systemic administration of mesoporous silica nanoparticles	301
Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth	287
Down-regulation of TNF-α via macrophage-targeted RNAi system for the treatment of acute inflammatory sepsis	285
The colon targeting efficacies of mesalazine medications and their impacts on the gut microbiome	271
In-situ-formed immunotherapeutic and hemostatic dual drug-loaded nanohydrogel for preventing postoperative recurrence of hepatocellular carcinoma	268
Inside Back Cover	265
Corrigendum to “Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch” [Journal of Controlled Release 372 (2024) 304–317]	234
Outside Back Cover	227
MSC-derived extracellular vesicles as nanotherapeutics for promoting aged liver regeneration	224
Multifunctional nanoparticles potentiate in-situ tumor vaccines via reversing insufficient Photothermal therapy by disrupting tumor vasculature	216
Delivery of DNA octahedra enhanced by focused ultrasound with microbubbles for glioma therapy	212
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules	201
A self-assembled graphene oxide adjuvant induces both enhanced humoral and cellular immune responses in influenza vaccine	192
Cavitation-assisted sonothrombolysis by asymmetrical nanostars for accelerated thrombolysis	188
An efficient (nano) silica - In glucan particles protein encapsulation approach for improved thermal stability	181
Collagenase-modified polydopamine nanoparticles for safe and effective vitreolysis	177
Autophagy-activating aluminum hydroxide nanovaccine for enhanced antigen presentation and anti-tumor immunity	175
The pharmacokinetic profile of mitomycin C released from an injectable supramolecular hydrogel in a rodent model	175
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs	174
Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis	173
Outside Front Cover	170

Lanthanide nanocrystals-based direct triple-state energy converters for mitophagy and ferroptosis-induced antitumor immunoreaction	169
Coordinated modulation of glucose metabolism and immunity via metal-drug nanovesicles for hepatocellular carcinoma therapy	155
Metal-phenolic network-based polymeric nanocarriers facilitating antibody cytoplasmic delivery and anti-tumor effects to orthotopic breast tumors	152
Multifunctional delivery strategies and nanoplatforms of SN-38 in cancer therapeutics	147
Designing and modeling nanomedicines towards image-guided drug delivery in hematological malignancies	143
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3	141
Outside Front Cover: Yisheng Peng et al	136
The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide for bone repair	133
Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling	132
Combinatorial physical methods for cellular therapy: Towards the future of cellular analysis?	132
Dynamic versus static testing and in vivo mechanical performance of poly(glycolide-trimethylene carbonate-ε-caprolactone) delayed release implants	131
Outside Back Cover	130
Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors	129
Integrative approaches to enhance adeno-associated viral gene delivery	129
Mechanism exploration of intestinal mucus penetration of nano-Se: regulated by polysaccharides with different functional groups and molecular weights	128
Alendronate-functionalized polymeric micelles target icaritin to bone for mitigating osteoporosis in a rat model	128
Orthogonal upconversion nanocarriers for combined photodynamic therapy and precisely triggered gene silencing in combating keloids	128
Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction	128
In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer	127
Oxygen-boosted fluorinated prodrug hybrid nanoassemblies for bidirectional amplification of breast cancer ferroptosis	125
Identification of functional biomarkers for personalized nanomedicine in advanced breast cancer in vitro models	123
White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin	122
Impact of interferon-γ on the target cell tropism of nanoparticles	122
Ferroptosis boosted oral cancer photodynamic therapy by carrier-free Sorafenib-Ce6 self-assembly nanoparticles	117
Hypoxia-responsive oncolytic conjugate triggers type-II immunogenic cell death for enhanced photodynamic immunotherapy	115
In vivo delivery of antioxidant enzymes with multi-functionalized lipid nanoparticles for sepsis therapy	113
Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation	112
Thermoresponsive polymeric dexamethasone prodrug for arthritis pain	112
Full-cycle study on developing a novel structured micromixer and evaluating the nanoparticle products as mRNA delivery carriers	111
Pickering emulsion-guided monomeric delivery of monophosphoryl lipid A for enhanced vaccination	107
Unleashing the potential of cell biomimetic nanoparticles: Strategies and challenges in their design and fabrication for therapeutic applications	103
Advance cardiac nanomedicine by targeting the pathophysiological characteristics of heart failure	103
Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives	101
Adaptable peptide-based therapeutics modulating tumor microenvironment for combinatorial radio-immunotherapy	101
Transdermal carbon monoxide delivery	100
Oral mucosal vaccination using integrated fiber microneedles	99
An engineered dual function peptide to repair fractured bones	99
Dasatinib and erianin co-loaded ion-responsive in-situ hydrogel for effective treatment of corneal neovascularization	98
Hybrid nanopotentiators with dual cascade amplification for glioma combined interventional therapy	98
Development of a thermostable oxytocin microneedle patch	98
Combination of multivalent DR5 receptor clustering agonists and histone deacetylase inhibitors for treatment of colon cancer	96
Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy	96
Modified montmorillonite armed probiotics with enhanced on-site mucus-depleted intestinal colonization and H2S scavenging for colitis treatment	96
Intraperitoneal drug delivery systems for peritoneal carcinomatosis: Bridging the gap between research and clinical implementation	95
Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis	95
Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment	92
Mechanisms of uptake and transport of particulate formulations in the small intestine	91
Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases	91
Complement opsonization of nanoparticles: Differences between humans and preclinical species	91
Extracellular vesicles for renal therapeutics: State of the art and future perspective	91

Dual-stimulus phototherapeutic nanogel for triggering pyroptosis to promote cancer immunotherapy	91
Self-assembly hydrogels of therapeutic agents for local drug delivery	91
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence	90
Enhanced browning of adipose tissue by mirabegron-microspheres	88
Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy	88
ZIF-8-modified hydrogel sequentially delivers angiogenic and osteogenic growth factors to accelerate vascularized bone regeneration	88
Bioorthogonal conjugation and responsive nanocoating of probiotics for inflammatory bowel disease	88
Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy	88
Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy	87
Micellar paclitaxel boosts ICD and chemo-immunotherapy of metastatic triple negative breast cancer	87
A smart cauliflower-like carrier for astaxanthin delivery to relieve colon inflammation	86
Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug	86