OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Controlled Release is 89. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
The pharmacokinetic profile of mitomycin C released from an injectable supramolecular hydrogel in a rodent model	494
Designing and modeling nanomedicines towards image-guided drug delivery in hematological malignancies	388
Coordinated modulation of glucose metabolism and immunity via metal-drug nanovesicles for hepatocellular carcinoma therapy	383
Outside Front Cover	350
Nanoparticle-based methionine and AICAR delivery elicits a robust antitumor immune response	342
Optimized bacterial delivery approaches for precision immunotherapy in breast cancer models	337
Inside Back Cover	325
Corrigendum to “Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch” [Journal of Controlled Release 372 (2024) 304–317]	319
Outside Back Cover	294
Outside Back Cover	267
An engineered dual function peptide to repair fractured bones	259
Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy	259
Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases	249
Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors	234
Site-specific engineering of S-Te-S bridged nano-prodrug: A dual equilibrium strategy for enhanced antitumor efficacy and safety of paclitaxel	230
Vascular endothelial cell-targeted mRNA delivery via synthetic lipid nanoparticles for venous thrombosis prevention	230
Mitochondria-targeted hybrid nanovesicles trigger immunogenic cell death and remodel tumor neutrophils for enhanced colorectal cancer immunotherapy	213
In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer	199
Integrative approaches to enhance adeno-associated viral gene delivery	196
Impact of interferon-γ on the target cell tropism of nanoparticles	195
Orthogonal upconversion nanocarriers for combined photodynamic therapy and precisely triggered gene silencing in combating keloids	195
Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?	194
Thermoresponsive polymeric dexamethasone prodrug for arthritis pain	192
Dual-stimulus phototherapeutic nanogel for triggering pyroptosis to promote cancer immunotherapy	191
Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy	187

Unleashing the potential of cell biomimetic nanoparticles: Strategies and challenges in their design and fabrication for therapeutic applications	164
Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy	160
MSC-derived extracellular vesicles as nanotherapeutics for promoting aged liver regeneration	158
Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction	158
Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug	153
Oxygen-boosted fluorinated prodrug hybrid nanoassemblies for bidirectional amplification of breast cancer ferroptosis	152
Mechanism exploration of intestinal mucus penetration of nano-Se: regulated by polysaccharides with different functional groups and molecular weights	152
Mechanisms of uptake and transport of particulate formulations in the small intestine	145
Alendronate-functionalized polymeric micelles target icaritin to bone for mitigating osteoporosis in a rat model	145
Melittin-incorporated nanomedicines for enhanced cancer immunotherapy	144
Customization of protein corona to reprogram cancer nanomedicines: Mechanistic insights and therapeutic implications	137
Autophagy-modulating biomembrane nanostructures: A robust anticancer weapon by modulating the inner and outer cancer environment	137
Biomaterial scaffolds for therapeutic immune cell engineering and delivery	137
Collagenase-modified polydopamine nanoparticles for safe and effective vitreolysis	135
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules	134
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3	129
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence	129
Outside Front Cover: Yisheng Peng et al	125
Dynamic versus static testing and in vivo mechanical performance of poly(glycolide-trimethylene carbonate-ε-caprolactone) delayed release implants	122
Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth	120
Metal-phenolic network-based polymeric nanocarriers facilitating antibody cytoplasmic delivery and anti-tumor effects to orthotopic breast tumors	117
Prediction of drug capturing by lipid emulsions in vivo for the treatment of a drug overdose	115
Outside Back Cover	113
A next-generation STING agonist MSA-2: From mechanism to application	113
Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis	112
Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy	111
Multifunctional nanoparticles potentiate in-situ tumor vaccines via reversing insufficient Photothermal therapy by disrupting tumor vasculature	110
Autophagy-activating aluminum hydroxide nanovaccine for enhanced antigen presentation and anti-tumor immunity	109
Full-cycle study on developing a novel structured micromixer and evaluating the nanoparticle products as mRNA delivery carriers	108
Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis	107
Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling	107
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes	106
A smart cauliflower-like carrier for astaxanthin delivery to relieve colon inflammation	105
In-situ-formed immunotherapeutic and hemostatic dual drug-loaded nanohydrogel for preventing postoperative recurrence of hepatocellular carcinoma	103
Multifunctional delivery strategies and nanoplatforms of SN-38 in cancer therapeutics	102
Single-cell RNA transcriptome landscape of murine liver following systemic administration of mesoporous silica nanoparticles	100
Lanthanide nanocrystals-based direct triple-state energy converters for mitophagy and ferroptosis-induced antitumor immunoreaction	100
White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin	100
Adaptable peptide-based therapeutics modulating tumor microenvironment for combinatorial radio-immunotherapy	99
Delivery of DNA octahedra enhanced by focused ultrasound with microbubbles for glioma therapy	99
Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis	99
The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide for bone repair	99
Self-assembly hydrogels of therapeutic agents for local drug delivery	98
A self-assembled graphene oxide adjuvant induces both enhanced humoral and cellular immune responses in influenza vaccine	98
Injectable nanocomposite hydrogel with cascade drug release for treatment of uveal melanoma	97
An efficient (nano) silica - In glucan particles protein encapsulation approach for improved thermal stability	96
Thiourea-modified poly(l-lysine) carriers with multiple hydrogen bonding interactions for safe and robust mRNA vaccine therapy	96
Hybrid nanopotentiators with dual cascade amplification for glioma combined interventional therapy	95
Identification of functional biomarkers for personalized nanomedicine in advanced breast cancer in vitro models	95
Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment	95

Healing with precision: A multi-functional hydrogel-bioactive glass dressing boosts infected wound recovery and enhances neurogenesis in the wound bed	94
The colon targeting efficacies of mesalazine medications and their impacts on the gut microbiome	94
Pickering emulsion-guided monomeric delivery of monophosphoryl lipid A for enhanced vaccination	94
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs	93
Cavitation-assisted sonothrombolysis by asymmetrical nanostars for accelerated thrombolysis	93
In vivo delivery of antioxidant enzymes with multi-functionalized lipid nanoparticles for sepsis therapy	93
Dendritic cell derived exosomes loaded neoantigens for personalized cancer immunotherapies	93
Combinatorial physical methods for cellular therapy: Towards the future of cellular analysis?	93
Hypoxia-responsive oncolytic conjugate triggers type-II immunogenic cell death for enhanced photodynamic immunotherapy	93
Enhanced browning of adipose tissue by mirabegron-microspheres	92
Oral mucosal vaccination using integrated fiber microneedles	92
Extracellular vesicles for renal therapeutics: State of the art and future perspective	92
Ferroptosis boosted oral cancer photodynamic therapy by carrier-free Sorafenib-Ce6 self-assembly nanoparticles	91
Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice	89
Micellar paclitaxel boosts ICD and chemo-immunotherapy of metastatic triple negative breast cancer	89
ZIF-8-modified hydrogel sequentially delivers angiogenic and osteogenic growth factors to accelerate vascularized bone regeneration	89