OOIR: Observatory of International Research

Papers

(The TQCC of Cancer and Metastasis Reviews is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Inhibitors of immune checkpoints—PD-1, PD-L1, CTLA-4—new opportunities for cancer patients and a new challenge for internists and general practitioners	100
Glioma: molecular signature and crossroads with tumor microenvironment	90
Checkpoint inhibitor therapy for metastatic triple-negative breast cancer	71
Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer	70
Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis	61
The adipocyte microenvironment and cancer	59
Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers	54
Interaction between adipose tissue and cancer cells: role for cancer progression	52
Targeting KRAS in pancreatic cancer: new drugs on the horizon	52
The obesity-breast cancer link: a multidisciplinary perspective	51
Neuroblastoma and the epigenome	51
Lipid metabolism reprogramming in renal cell carcinoma	49
The comprehensive landscape of miR-34a in cancer research	45
Gastrointestinal stromal tumor: a review of current and emerging therapies	43
The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance	41
Anti-HER2 therapy in metastatic breast cancer: many choices and future directions	40
The tumor microenvironment in pancreatic ductal adenocarcinoma: current perspectives and future directions	38
An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression	37
Neutrophil-derived granule cargoes: paving the way for tumor growth and progression	36
Targeting the cytoskeleton against metastatic dissemination	36
Inflammatory bowel disease and carcinogenesis	35
Rethinking the biology of metastatic melanoma: a holistic approach	33
Role of non-coding RNAs in tumor progression and metastasis in pancreatic cancer	32
Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity	31
Centrosome amplification: a quantifiable cancer cell trait with prognostic value in solid malignancies	30

The role of caspase-8 in the tumor microenvironment of ovarian cancer	30
The role of microbiome in pancreatic cancer	30
The race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options	30
Cyclin-dependent kinase inhibitors in head and neck cancer and glioblastoma—backbone or add-on in immune-oncology?	28
Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis	27
Nanoparticle-mediated cancer cell therapy: basic science to clinical applications	27
Obesity: a perfect storm for carcinogenesis	27
Platelets as messengers of early-stage cancer	25
Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution	25
Metformin: review of epidemiology and mechanisms of action in pancreatic cancer	24
Treatment against glucose-dependent cancers through metabolic PFKFB3 targeting of glycolytic flux	24
Role of myeloid-derived suppressor cells in metastasis	23
Exosomes: a new perspective in EGFR-mutated lung cancer	23
A bi-directional dialog between vascular cells and monocytes/macrophages regulates tumor progression	23
Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance	23
The role of the metabolite cargo of extracellular vesicles in tumor progression	23
Adipocytokines and disease progression in endometrial cancer: a systematic review	22
Mucins reprogram stemness, metabolism and promote chemoresistance during cancer progression	21
Visualizing cancer extravasation: from mechanistic studies to drug development	21
Dormant cancer cells: programmed quiescence, senescence, or both?	21
Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance	20
Safety of radiosurgery concurrent with systemic therapy (chemotherapy, targeted therapy, and/or immunotherapy) in brain metastases: a systematic review	20
Targeting DNA damage repair pathways in pancreas cancer	19
Progression and metastasis of small cell lung carcinoma: the role of the PI3K/Akt/mTOR pathway and metabolic alterations	19
The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer	19
Extracellular citrate and metabolic adaptations of cancer cells	19
The role of tumor heterogeneity in immune-tumor interactions	19
Epigenetic modulation of immunotherapy and implications in head and neck cancer	19
Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic?	19
The multifaceted roles of the chemokines CCL2 and CXCL12 in osteophilic metastatic cancers	19
Informing the new developments and future of cancer immunotherapy	19
Mechanistic insights into the interplays between neutrophils and other immune cells in cancer development and progression	19
Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?	18
The role of metabolic ecosystem in cancer progression — metabolic plasticity and mTOR hyperactivity in tumor tissues	18
Breast cancer microenvironment and obesity: challenges for therapy	18
Liquid biopsy for monitoring of tumor dormancy and early detection of disease recurrence in solid tumors	18
Natural compounds targeting nuclear receptors for effective cancer therapy	17
Debris-stimulated tumor growth: a Pandora’s box?	17
Short-chain fatty acids in cancer pathogenesis	16
What do cellular responses to acidity tell us about cancer?	16
Regulation of dormancy during tumor dissemination: the role of the ECM	16
Macrophages in multiple myeloma: key roles and therapeutic strategies	15
Systematic review of the receptor tyrosine kinase superfamily in neuroblastoma pathophysiology	15
A multidisciplinary perspective on the complex interactions between sleep, circadian, and metabolic disruption in cancer patients	15
MicroRNAs as a clue to overcome breast cancer treatment resistance	15
Insights into the role of senescence in tumor dormancy: mechanisms and applications	15