Cancer and Metastasis Reviews

Article	Citations
Gastric cancer: a comprehensive review of current and future treatment strategies	299
The role of fibroblast activation protein in health and malignancy	175
Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?	156
Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?	156
Molecular epidemiology and diagnostics of KRAS mutations in human cancer	147
FOXO transcription factor family in cancer and metastasis	139
CDK7 inhibitors as anticancer drugs	99
Lung cancer identification: a review on detection and classification	97
Molecular and cellular mechanisms underlying brain metastasis of breast cancer	77
Regulation of breast cancer metastasis signaling by miRNAs	74
Inhibitors of immune checkpoints—PD-1, PD-L1, CTLA-4—new opportunities for cancer patients and a new challenge for internists and general practitioners	72
Glioma: molecular signature and crossroads with tumor microenvironment	65
Current therapy of KRAS-mutant lung cancer	62
Wnts and the hallmarks of cancer	57
Checkpoint inhibitor therapy for metastatic triple-negative breast cancer	57
Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer	56
Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis	51
Emerging links between endosomal pH and cancer	49
The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment	48
Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis	48
Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer	46
Neuroblastoma and the epigenome	46
The adipocyte microenvironment and cancer	43
Targeting KRAS in pancreatic cancer: new drugs on the horizon	41
Interaction between adipose tissue and cancer cells: role for cancer progression	41

Lipid metabolism reprogramming in renal cell carcinoma	38
The obesity-breast cancer link: a multidisciplinary perspective	37
The comprehensive landscape of miR-34a in cancer research	37
Gastrointestinal stromal tumor: a review of current and emerging therapies	36
Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy	34
The role of lipid species in membranes and cancer-related changes	33
Targeting the cytoskeleton against metastatic dissemination	33
An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression	32
The effects of mutant Ras proteins on the cell signalome	31
The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance	31
Rethinking the biology of metastatic melanoma: a holistic approach	30
Tyrosine phosphorylation of tumor cell caveolin-1: impact on cancer progression	30
Neutrophil-derived granule cargoes: paving the way for tumor growth and progression	30
Flotillin membrane domains in cancer	29
The tumor microenvironment in pancreatic ductal adenocarcinoma: current perspectives and future directions	29
Glycosylation and raft endocytosis in cancer	29
Long non-coding RNA: A recently accentuated molecule in chemoresistance in cancer	29
Role of non-coding RNAs in tumor progression and metastasis in pancreatic cancer	29
Caveolin-1, a master regulator of cellular senescence	28
Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis	28
Molecular mediators of peritoneal metastasis in pancreatic cancer	28
The role of microbiome in pancreatic cancer	27
The role of caspase-8 in the tumor microenvironment of ovarian cancer	25
K-Ras prenylation as a potential anticancer target	25
Unraveling mucin domains in cancer and metastasis: when protectors become predators	24
MDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold protein	24
Epigenetic dynamics in cancer stem cell dormancy	24
The race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options	23
Inflammatory bowel disease and carcinogenesis	23
Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity	23
Anti-HER2 therapy in metastatic breast cancer: many choices and future directions	23
Centrosome amplification: a quantifiable cancer cell trait with prognostic value in solid malignancies	22
Cyclin-dependent kinase inhibitors in head and neck cancer and glioblastoma—backbone or add-on in immune-oncology?	22
Platelets as messengers of early-stage cancer	22
The role of the metabolite cargo of extracellular vesicles in tumor progression	21
Obesity: a perfect storm for carcinogenesis	21
Role of myeloid-derived suppressor cells in metastasis	21
Role of linoleic acid-derived oxylipins in cancer	20
Metformin: review of epidemiology and mechanisms of action in pancreatic cancer	20
Current methods in translational cancer research	19
Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution	19
Current therapy of advanced colorectal cancer according to RAS/RAF mutational status	19
Exosomes: a new perspective in EGFR-mutated lung cancer	19
Platelets in aging and cancer—“double-edged sword”	19
Treatment against glucose-dependent cancers through metabolic PFKFB3 targeting of glycolytic flux	19
Extracellular citrate and metabolic adaptations of cancer cells	18
Safety of radiosurgery concurrent with systemic therapy (chemotherapy, targeted therapy, and/or immunotherapy) in brain metastases: a systematic review	18
Mechanistic insights into the interplays between neutrophils and other immune cells in cancer development and progression	18
Membrane tension buffering by caveolae: a role in cancer?	18
Multiple roles of HOX proteins in Metastasis: Let me count the ways	18

Targeting DNA damage repair pathways in pancreas cancer	18
Epigenetic modulation of immunotherapy and implications in head and neck cancer	18
Informing the new developments and future of cancer immunotherapy	17
Visualizing cancer extravasation: from mechanistic studies to drug development	17
A bi-directional dialog between vascular cells and monocytes/macrophages regulates tumor progression	17
Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance	17
Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation	17
Adipocytokines and disease progression in endometrial cancer: a systematic review	16
Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery	16
Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis	16
Debris-stimulated tumor growth: a Pandora’s box?	15
The multifaceted roles of the chemokines CCL2 and CXCL12 in osteophilic metastatic cancers	15
Small molecule inhibitors of RAS proteins with oncogenic mutations	15
What do cellular responses to acidity tell us about cancer?	15
Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?	14
Structure-based inhibitor design of mutant RAS proteins—a paradigm shift	14
Endothelial caveolin and its scaffolding domain in cancer	14
Nanoparticle-mediated cancer cell therapy: basic science to clinical applications	14
Progression and metastasis of small cell lung carcinoma: the role of the PI3K/Akt/mTOR pathway and metabolic alterations	14
The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer	14
A multidisciplinary perspective on the complex interactions between sleep, circadian, and metabolic disruption in cancer patients	14
Mucins reprogram stemness, metabolism and promote chemoresistance during cancer progression	14
The role of tumor heterogeneity in immune-tumor interactions	13
Glycosylation as a regulator of site-specific metastasis	13
A perspective on the early days of RAS research	13
Breast cancer microenvironment and obesity: challenges for therapy	13
Potential mechanisms of tumor progression associated with postoperative infectious complications	13
Beyond tradition and convention: benefits of non-traditional model organisms in cancer research	12
MicroRNAs as a clue to overcome breast cancer treatment resistance	12
The role of metabolic ecosystem in cancer progression — metabolic plasticity and mTOR hyperactivity in tumor tissues	12
RNA-biology ruling cancer progression? Focus on 3′UTRs and splicing	12
MHC heterogeneity and response of metastases to immunotherapy	12
Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers	12
Splice variants of RAS—translational significance	11
Mesenchymal stromal cell senescence in haematological malignancies	11
Oncobiology and treatment of breast cancer in young women	11
Natural compounds targeting nuclear receptors for effective cancer therapy	11
Macrophages in multiple myeloma: key roles and therapeutic strategies	11
Emerging roles of epithelial-mesenchymal plasticity in invasion-metastasis cascade and therapy resistance	11
Rho GTPases in cancer radiotherapy and metastasis	11
A systems biology approach to discovering pathway signaling dysregulation in metastasis	10
Systematic review of the receptor tyrosine kinase superfamily in neuroblastoma pathophysiology	10
Liquid biopsy for monitoring of tumor dormancy and early detection of disease recurrence in solid tumors	10
Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression	10
Hypoxia signaling in hepatocellular carcinoma: Challenges and therapeutic opportunities	9
Implications of prognosis-associated genes in pancreatic tumor metastasis: lessons from global studies in bioinformatics	9
Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry	9
The gut microbiome, immune check point inhibition and immune-related adverse events in non-small cell lung cancer	9
Regulation of dormancy during tumor dissemination: the role of the ECM	9
Decoding human cancer with whole genome sequencing: a review of PCAWG Project studies published in February 2020	9
Connecting the Human Microbiome and Pancreatic Cancer	9
Models of pancreatic ductal adenocarcinoma	9
Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?	9
The cure from within? a review of the microbiome and diet in melanoma	9
The multifaceted mechanisms of malignant glioblastoma progression and clinical implications	9
Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases	9
Insights into the role of senescence in tumor dormancy: mechanisms and applications	9
Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets	9
Nanotechnology-aided advancement in the combating of cancer metastasis	8
Understanding metabolic alterations and heterogeneity in cancer progression through validated immunodetection of key molecular components: a case of carbonic anhydrase IX	8
Brain tumor vessels—a barrier for drug delivery	8
Targeting lipid metabolism in cancer: neuroblastoma	8
Obesity, cancer risk, and time-restricted eating	8
Dormant cancer cells: programmed quiescence, senescence, or both?	8
Mechanisms behind context-dependent role of glucocorticoids in breast cancer progression	8
Emerging roles for myeloid immune cells in bone metastasis	8
The timing of adiposity and changes in the life course on the risk of cancer	8
Involvement of redox signalling in tumour cell dormancy and metastasis	7
Autophagy, molecular chaperones, and unfolded protein response as promoters of tumor recurrence	7
Immunotherapy for triple negative breast cancer: the end of the beginning or the beginning of the end?	7
The role of obesity and bariatric surgery-induced weight loss in breast cancer	7
Impact of posttranslational modifications in pancreatic carcinogenesis and treatments	7
Role of myeloid-derived suppressor cells in tumor recurrence	7
The emerging roles of circular RNAs in vessel co-option and vasculogenic mimicry: clinical insights for anti-angiogenic therapy in cancers	7
Cohesive cancer invasion of the biophysical barrier of smooth muscle	7
Model systems in SDHx-related pheochromocytoma/paraganglioma	7
Pancreatic cancer pathology viewed in the light of evolution	7
Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance	7
The effect of obesity on adipose-derived stromal cells and adipose tissue and their impact on cancer	7
Notch signaling in malignant gliomas: supporting tumor growth and the vascular environment	7

Multiprong control of glioblastoma multiforme invasiveness: blockade of pro-inflammatory signaling, anti-angiogenesis, and homeostasis restoration

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