Biochimica et Biophysica Acta-Molecular Cell Research

Papers
(The median citation count of Biochimica et Biophysica Acta-Molecular Cell Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)
ArticleCitations
N-acetyltyrosine-induced redox signaling in hormesis229
Cell adhesion an important determinant of myogenesis and satellite cell activity115
Combating deleterious phase transitions in neurodegenerative disease97
Interactions with sulfur acceptors modulate the reactivity of cysteine desulfurases and define their physiological functions73
Rcf proteins and their differential specificity for respiratory chain complexes: A unique role for Rcf2 on oxygen sensitive supercomplexes?73
Suppression of GATA3 promotes epithelial-mesenchymal transition and simultaneous cellular senescence in human extravillous trophoblasts73
The role of circadian gene CLOCK in cancer65
Fe-S biogenesis by SMS and SUF pathways: A focus on the assembly step61
Critical residues in the Ku70 von Willebrand A domain mediate Ku interaction with the LigIV-XRCC4 complex in non-homologous end-joining57
Artificial mitochondrial transplantation (AMT) reverses aging of mesenchymal stromal cells and improves their immunomodulatory properties in LPS-induced synoviocytes inflammation55
Tumour suppressor protein sMEK1 links to IRE1 signalling pathway to modulate its activity during ER stress49
Iron‑sulfur cluster synthesis in plastids by the SUF system: A mechanistic and structural perspective45
Tetrameric, active PKM2 inhibits IP3 receptors, potentially requiring GRP75 as an additional interaction partner45
Editorial Board45
Ferroptosis in calcium oxalate kidney stone formation and the possible regulatory mechanism of ANKRD145
The synergistic function of long and short forms of β4GalT1 in p53-mediated drug resistance in bladder cancer cells38
Cracking outer membrane biogenesis38
Control of cell signaling by Arf GTPases and their regulators: Focus on links to cancer and other GTPase families38
Impaired autophagic flux and dedifferentiation in podocytes lacking Asah1 gene: Role of lysosomal TRPML1 channel35
In memoriam David MacLennan (1937–2020)34
Reviewer Acknowledgment34
Specific binding of VegT mRNA localization signal to membranes in Xenopus oocytes34
The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's disease32
Autophagy and metabolic aging: Current understanding and future applications30
Extracellular AGR2 triggers lung tumour cell proliferation through repression of p21CIP128
Microbial imidazole propionate affects glomerular filtration rate in patients with diabetic nephropathy through association with HSP90α28
FTMT-dependent mitophagy is crucial for ferroptosis resistance in cardiac fibroblast28
Uniparental parthenogenetic embryonic stem cell derivatives adaptable for bone and cartilage regeneration27
The IP3 receptor and Ca2+ signaling in trypanosomes26
Editorial Board25
Editorial Board25
EID3 inhibits the osteogenic differentiation of periodontal ligament stem cells and mediates the signal transduction of TAZ-EID3-AKT/MTOR/ERK25
Erythropoietin enhances iron bioavailability in HepG2 cells by downregulating hepcidin through mTOR, C/EBPα and HIF-1α24
Rotavirus non-structural protein 4 usurps host cellular RIPK1-RIPK3 complex to induce MLKL-dependent necroptotic cell death24
Targeting epigenetic mechanisms to overcome venetoclax resistance24
Knockdown of heat shock protein family D member 1 (HSPD1) in lung cancer cell altered secretome profile and cancer-associated fibroblast induction24
Genetic dissection of the bacterial Fe-S protein biogenesis machineries23
Differentiation-inducing factor-1 potentiates adipogenic differentiation and attenuates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells23
Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease23
Novel targeting assay uncovers targeting information within peroxisomal ABC transporter Pxa121
Intracellular ion changes induced by the exposure to beta-amyloid can be explained by the formation of channels in the lysosomal membranes21
Using display technologies to identify macrocyclic peptide antibiotics21
Evaluation of CD98 light chain-LAT1 as a potential marker of cancer stem-like cells in glioblastoma21
The heart arrhythmia-linked D130G calmodulin mutation causes premature inhibitory autophosphorylation of CaMKII20
Double knockout of vitamin D receptor and its coactivator mediator complex subunit 1 unexpectedly enhances epidermal permeability barrier function in mice20
UBXN7 cofactor of CRL3KEAP1 and CRL2VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins19
Early developmental, meiosis-specific proteins — Spo11, Msh4-1, and Msh5 — Affect subsequent genome reorganization in Paramecium tetraurelia19
FCHSD2 cooperates with CDC42 and N-WASP to regulate cell protrusion formation19
Cell death as a result of calcium signaling modulation: A cancer-centric prospective19
5,7-Dihydroxy-4-methylcoumarin modulates the JNK/FoxO1 signaling pathway to attenuate cisplatin-induced ototoxicity by suppressing oxidative stress and apoptosis in vitro19
HIPK2 in the physiology of nervous system and its implications in neurological disorders18
Mitophagy at the crossroads of cancer development: Exploring the role of mitophagy in tumor progression and therapy resistance18
Expression of the tumor-expressed protein MageB2 enhances rRNA transcription17
Interaction of novel proteins, centrin4 and protein of centriole in Leishmania parasite and their effects on the parasite growth17
Autophagy regulates transforming growth factor β signaling and receptor trafficking17
A multifunctional peroxidase-based reaction for imaging, sensing and networking of spatial biology17
Mitochondrial dysfunction mediates neuronal cell response to DMMB photodynamic therapy16
Galectin-3 S-glutathionylation regulates its effect on adipocyte insulin signaling16
A new method to estimate 3D cell parameters from 2D microscopy images16
Isoginkgetin leads to decreased protein synthesis and activates an ATF4-dependent transcriptional response15
The role of GSK3 in metabolic pathway perturbations in cancer15
12th Tuscany Retreat on Cancer Research and Apoptosis: Genetic profiling, resistance mechanisms and novel treatment concepts in cancer and neurodegeneration15
Differential regulation of the glucocorticoid receptor nucleocytoplasmic shuttling by TPR-domain proteins15
The ribosomal protein eL21 interacts with the protein lysine methyltransferase SMYD2 and regulates its steady state levels15
Identification of immune infiltration landscape on prognosis and therapy of the ferroptosis-related genes signature in breast cancer15
Ligand-dependent intracellular trafficking of the G protein-coupled P2Y6 receptor15
TMEM70 forms oligomeric scaffolds within mitochondrial cristae promoting in situ assembly of mammalian ATP synthase proton channel15
The anti-parallel dimer binding interface in STAT3 transcription factor is required for the inactivation of cytokine-mediated signal transduction15
Magnetic field-induced Ca2+ intake by mesenchymal stem cells is mediated by intracellular Zn2+ and accompanied by a Zn2+ influx15
The lipid flippase ATP10B enables cellular lipid uptake under stress conditions15
Resistance to CDK4/6 inhibition: Mechanisms and strategies to overcome a therapeutic problem in the treatment of hormone receptor-positive metastatic breast cancer15
Light chain subunit of a poorly soluble human IgG2λ crystallizes in physiological pH environment both in cellulo and in vitro14
Molecular tuning of calcium dependent processes by neuronal calcium sensor proteins in the retina13
LacNAc modification in bone marrow stromal cells enhances resistance of myelodysplastic syndrome cells to chemotherapeutic drugs13
Striatin family proteins: The neglected scaffolds13
Sphingosine-1-phosphate induces migration of microglial cells via activation of volume-sensitive anion channels, ATP secretion and activation of purinergic receptors13
Menadione-induced endothelial inflammation detected by Raman spectroscopy13
The role of adhesion molecules in osteocalcin-induced effects on glucose and lipid metabolism in adipocytes13
Unraveling the interplay between vital organelle stress and oxidative stress in idiopathic pulmonary fibrosis13
Phospholipase A2-activating protein induces mitophagy through anti-apoptotic MCL1-mediated NLRX1 oligomerization13
The first junior European Calcium Society meeting: calcium research across scales, Kingdoms and countries13
Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations13
Cav1 channels is also a story of non excitable cells: Application to calcium signalling in two different non related models13
Mossy cells of the dentate gyrus: Drivers or inhibitors of epileptic seizures?13
Hypoxia induced ALKBH5 prevents spontaneous abortion by mediating m6A-demethylation of SMAD1/5 mRNAs12
Fe/S proteins in microbial sulfur oxidation12
Chaperone function in Fe–S protein biogenesis: Three possible scenarios.12
Snail transcription factors – Characteristics, regulation and molecular targets relevant in vital cellular activities of ovarian cancer cells12
Editorial for the BBA-MCR Special Issue on “Biogenesis and Function Iron-sulfur Proteins”12
Protein kinase D1 — A targetable mediator of pancreatic cancer development12
Inhibiting autophagy by miR-19a-3p/PTEN regulation protected retinal pigment epithelial cells from hyperglycemic damage12
Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling12
It's time to die: BH3 mimetics in solid tumors12
Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation12
Adipocyte-conditioned medium induces tamoxifen resistance by activating PI3K/Akt/mTOR pathway in estrogen receptor-positive breast cancer cells12
Involvement of the alpha-subunit N-terminus in the mechanism of the Na+,K+-ATPase12
The role of ncRNA in the co-regulation of autophagy and exosome pathways during cancer progression11
Insights into eukaryotic translation initiation factor 5A: Its role and mechanisms in protein synthesis11
Ambra1 in exosomes secreted by HK-2 cells damaged by supersaturated oxalate induce mitophagy and autophagy-ferroptosis in normal HK-2 cells to participate in the occurrence of kidney stones11
Replacement of Lys27 by asparagine in the SERCA regulator myoregulin: A Ca2+ affinity modulator or a catalytic activity switch?11
MGMT in TMZ-based glioma therapy: Multifaceted insights and clinical trial perspectives11
WDR45-dependent impairment of cell cycle in fibroblasts of patients with beta propeller protein-associated neurodegeneration (BPAN)11
NAADP-binding proteins — Linking NAADP signaling to cancer and immunity11
TGM2 positively regulates myoblast differentiation via enhancing the mTOR signaling11
Knockdown of BRAWNIN minimally affect mitochondrial complex III assembly in human cells11
SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes11
NEDD4L-mediated RASGRP2 suppresses high-glucose and oxLDL-induced vascular endothelial cell dysfunctions by activating Rap1 and R-Ras11
IL-17 promotes melanoma through TRAF2 as a scaffold protein recruiting PIAS2 and ELAVL1 to induce EPHA511
E3 ubiquitin ligases and deubiquitinases in colorectal cancer: Emerging molecular insights and therapeutic opportunities11
Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans11
Fructose-induced perturbation in cellular proteostasis via RPS6KB1 promotes hepatic steatosis11
Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane11
Mechanism of mitochondrial [2Fe-2S] cluster biosynthesis11
Blockage of polycystin-2 alleviates myocardial ischemia/reperfusion injury by inhibiting autophagy through the Ca2+/Akt/Beclin 1 pathway10
Bacterial envelope stress responses: Essential adaptors and attractive targets10
The role of proteolysis in interleukin-11 signaling10
Enhanced radiotherapy susceptibility in NSCLC through palbociclib-mediated PP5 inhibition10
The C2 domain of calpain 5 contributes to enzyme activation and membrane localization10
MageC2 protein is upregulated by oncogenic activation of MAPK pathway and causes impairment of the p53 transactivation function10
The role of RNA splicing factor PTBP1 in neuronal development10
ELAVL1 governs breast cancer malignancy by regulating cell stemness10
Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease10
Study of ER stress and apoptotic proteins in the heart and tumor exposed to doxorubicin10
Peripheral IL-6/STAT3 signaling promotes beiging of white fat10
Harnessing iron‑sulfur enzymes for synthetic biology10
AGR2 knockdown induces ER stress and mitochondria fission to facilitate pancreatic cancer cell death10
Ubiquitin-specific peptidase 11 selectively interacts with and deubiquitination-dependently stabilizes diacylglycerol kinase δ to maintain cellular glucose uptake10
Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation10
LINC01116 modulates EMT process via binding with AGO1 mRNA in oesophageal squamous cell carcinoma10
FTO/RUNX2 signaling axis promotes cementoblast differentiation under normal and inflammatory condition10
Corrigendum to “MageC2 protein is upregulated by oncogenic activation of MAPK pathway and causes impairment of the p53 transactivation function” [Biochim. Biophys. Acta, Mol. Cell Res. vol. 1868 (Issu10
Endoplasmic reticulum stress induced autophagy in cancer and its potential interactions with apoptosis and ferroptosis10
Liquid-liquid phase separation as a common organizing principle of intracellular space and biomembranes providing dynamic adaptive responses9
Unraveling the inhibitory mechanism of adenylyl cyclase 8E: New insights into regulatory pathways of cAMP signal integration9
The anti-angiogenic and anti-vasculogenic mimicry effects of GN25 in endothelial and glioma cells9
Overexpression of PEX14 results in mistargeting to mitochondria, accompanied by organelle fragmentation and clustering in human embryonic kidney cells9
Editorial Board9
DOCK2 deficiency alleviates neuroinflammation and affords neuroprotection after spinal cord injury9
Cellular effects of BAPTA: Are they only about Ca2+ chelation?9
Fam96b recruits brain-type creatine kinase to fuel mitotic spindle formation9
Involvement of aquaporins in Shiga toxin-induced swelling and water transport dysfunction in human renal microvascular endothelial cells9
IGF2BP3-EGFR-AKT axis promotes breast cancer MDA-MB-231 cell growth9
Micropeptide MPM regulates cardiomyocyte proliferation and heart growth via the AKT pathway9
Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathways9
Acetylenic tricyclic bis-(cyano enone) interacts with Cys 374 of actin, a residue necessary for stress fiber formation and cell migration9
Modulation of biomolecular phase behavior by metal ions9
Cdc25A phosphatase is activated and mediates neuronal cell death by PUMA via pRb/E2F1 pathway in a model of Parkinson's disease8
FXR controls insulin content by regulating Foxa2-mediated insulin transcription8
Learning-induced plasticity in the barrel cortex is disrupted by inhibition of layer 4 somatostatin-containing interneurons8
Organ-on-a-chip models for elucidating the cellular biology of infectious diseases8
Murine neonatal dermal fibroblast acquires a lymphoid tissue organizer cell-like activity upon synergistic activation of TNF-α receptor and LTβ receptor8
FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF38
Ca2+ puffs underlie adhesion-triggered Ca2+ microdomains in T cells8
Editorial Board8
Ryanodine receptor calcium release channels in trophoblasts and their role in cell migration8
USP7 imparts partial EMT state in colorectal cancer by stabilizing the RNA helicase DDX3X and augmenting Wnt/β-catenin signaling8
The dynamics of the electrotactic reaction of mouse 3T3 fibroblasts8
GAA deficiency promotes angiogenesis through upregulation of Rac1 induced by autophagy disorder8
Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitin-specific protease C-terminally anchored in the endoplasmic reticulum8
Editorial Board8
The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft18
Site-1 and site-2 proteases: A team of two in regulated proteolysis8
Changes in the levels of α-actinin-4 in differentiating human myeloid leukemia cells induced by retinoic acid8
Ageing modulates human dermal fibroblast contractility: Quantification using nano-biomechanical testing8
Editorial Board8
Expression of a kinase inactive SLK is embryonic lethal and impairs cell migration in fibroblasts7
Raman microscopy reveals how cell inflammation activates glucose and lipid metabolism7
Editorial Board7
On the track of the lipid transport pathway of the phospholipid flippase ATP8A2 - Mutation analysis of residues of the transmembrane segments M1, M2, M3 and M47
Organellar calcium signaling in plants: An update7
Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice7
TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication7
ARRB1 inhibits extracellular matrix degradation and apoptosis of nucleus pulposus cells by promoting autophagy and attenuates intervertebral disc degeneration7
A fluorescent protein C-terminal fusion knock-in is functional with TRPA1 but not TRPC57
GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression7
Role of pathogen's effectors in understanding host-pathogen interaction7
A tribute to Professor Sir Michael J. Berridge FRS (1938–2020)7
Regulatory role of RBM39 in acute myeloid leukemia: Mediation through the PI3K/AKT pathway7
State without borders: Membrane-less organelles and liquid–liquid phase transitions7
The bacterial magnesium transporter MgtA reveals highly selective interaction with specific cardiolipin species7
Editorial Board7
RANKL regulates differentially breast cancer stem cell properties through its RANK and LGR4 receptors7
BAG3 epigenetically regulates GALNT10 expression via WDR5 and facilitates the stem cell-like properties of platin-resistant ovarian cancer cells7
GATA3: Orchestrating cellular fate through differentiation and proliferation7
Nuclear receptor 4A1 ameliorates renal fibrosis by inhibiting vascular endothelial growth factor A induced angiogenesis in UUO rats7
Assembly of bacterial cell division protein FtsZ into dynamic biomolecular condensates7
Wnt/β-catenin signaling inhibits oxidative stress-induced ferroptosis to improve interstitial cystitis/bladder pain syndrome by reducing NF-κB7
Interactions between reactive oxygen species and autophagy7
CISD2 maintains cellular homeostasis7
Editorial Board7
Signal peptide peptidase-like 2 proteases: Regulatory switches or proteasome of the membrane?7
Revealing PACMA 31 as a new chemical type TrxR inhibitor to promote cancer cell apoptosis7
Editorial Board6
YidC as a potential antibiotic target6
Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signaling pathway6
ERK phosphorylation is dependent on cell adhesion in a subset of pediatric sarcoma cell lines6
Coenzyme A levels influence protein acetylation, CoAlation and 4′-phosphopantetheinylation: Expanding the impact of a metabolic nexus molecule6
Editorial Board6
The alkalinizing, lysosomotropic agent ML-9 induces a pH-dependent depletion of ER Ca2+ stores in cellulo6
Stability of Rad51 recombinase and persistence of Rad51 DNA repair foci depends on post-translational modifiers, ubiquitin and SUMO6
An unusual conformation from Na+-sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na+-binding6
Mitochondrial dynamics and sex-specific responses in the developing rat hippocampus: Effect of perinatal asphyxia and mesenchymal stem cell Secretome treatment6
ULK1 inhibition attenuates telomerase activity in hepatic cells6
c-Jun phosphorylated by JNK is required for protecting Gli2 from proteasomal-ubiquitin degradation by PGE2-JNK signaling axis6
Generation of a pHSPA6 gene-based multifunctional live cell sensor6
Role of CNC1 gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in S. cerevisiae model of ALS6
Amplification of protease-activated receptors signaling in sporadic cerebral cavernous malformation endothelial cells6
Tracing the evolutionary history of Ca2+-signaling modulation by human Bcl-2: Insights from the Capsaspora owczarzaki IP3 receptor ortholog6
Analysis of cf-mtDNA and cf-nDNA fragment size distribution using different isolation methods in BV-2 cell supernatant of starvation-induced autophagy6
An IgM monoclonal antibody against domain 1 of CD147 induces non-canonical RIPK-independent necroptosis in a cell type specific manner in hepatocellular carcinoma cells6
CARM1 deficiency inhibits osteoblastic differentiation of bone marrow mesenchymal stem cells and delays osteogenesis in mice6
Evolution of the sodium pump6
Small but mighty: Atg8s and Rabs in membrane dynamics during autophagy6
Adipocyte-driven unfolded protein response is a shared transcriptomic signature of metastatic prostate carcinoma cells6
Molecular chaperone function of stress inducible Hsp70 is critical for intracellular multiplication of Toxoplasma gondii6
GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists6
Heat stress disrupts intestinal stem cell migration and differentiation along the crypt–villus axis through FAK signaling6
Introducing the Special Issue on “Emerging Concepts & Non-Canonical Pathways in Cellular Signaling”6
The MDMX acidic domain competes with the p53 transactivation domain for MDM2 N-terminal domain binding6
In vivo brain imaging of mitochondrial Ca2+ in neurodegenerative diseases with multiphoton microscopy6
SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis6
Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells6
RNF2 promotes the progression of colon cancer by regulating ubiquitination and degradation of IRF46
New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms6
Comparative subcellular localization of NRF2 and KEAP1 during the hepatocellular carcinoma development in vivo6
Transcriptome-scale methods for uncovering subcellular RNA localization mechanisms5
Surveying the landscape of emerging and understudied cell death mechanisms5
TGF-β2 increases cell-cell communication in chondrocytes via p-Smad3 signalling5
Raman and fluorescence imaging of phospholipidosis induced by cationic amphiphilic drugs in endothelial cells5
Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling5
Exogenous H2S alleviates senescence of glomerular mesangial cells through up-regulating mitophagy by activation of AMPK-ULK1-PINK1-parkin pathway in mice5
Iron‑sulfur cluster biogenesis and function in Apicomplexa parasites5
Targeting SOCS2 alleviates myocardial fibrosis by reducing nuclear translocation of β-catenin5
Proteomic strategies to interrogate the Fe-S proteome5
The role of ferroptosis in metabolic diseases5
Mitochondria function in cytoplasmic FeS protein biogenesis5
The importance of Ca2+ microdomains for the adaptive immune response5
Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway5
NEK2 overexpression aggravates IL-22-induced keratinocyte proliferation and cytokine level increases and IMQ-induced psoriasis-like dermatitis5
Impaired insulin signaling and diet-induced type 3 diabetes pathophysiology increase amyloid β expression in the Drosophila model of Alzheimer's disease5
PIEZO1 mediates matrix stiffness-induced tumor progression in kidney renal clear cell carcinoma by activating the Ca2+/Calpain/YAP pathway5
Unraveling the multifaceted nature of the nuclear function of mTOR5
A cellular atlas of calcineurin signaling5
Iron‑sulfur clusters in viral proteins: Exploring their elusive nature, roles and new avenues for targeting infections5
Human amylin aggregates release within exosomes as a protective mechanism in pancreatic β cells: Pancreatic β-hippocampal cell communication5
NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells5
c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device5
p21-activated kinase 6 controls mitosis and hepatocellular carcinoma progression by regulating Eg55
Oncogenic KRAS mutations modulate BAX-mediated cell death5
Metformin induces apoptosis in TRAIL-resistant colorectal cancer cells5
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