Antiviral Research

Article	Citations
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro	1408
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade	1346
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro	690
Coronavirus membrane fusion mechanism offers a potential target for antiviral development	610
Of chloroquine and COVID-19	417
Type 1 interferons as a potential treatment against COVID-19	393
Antiviral activities of type I interferons to SARS-CoV-2 infection	333
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern	294
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites	254
A potential role for integrins in host cell entry by SARS-CoV-2	253
The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer	238
Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions	229
Hepatitis B virus biology and life cycle	152
Lower prevalence of antibodies neutralizing SARS-CoV-2 in group O French blood donors	113
In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2	113
Identification of SARS-CoV RBD-targeting monoclonal antibodies with cross-reactive or neutralizing activity against SARS-CoV-2	103
A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19	95
The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters	90
Hepatitis B virus cccDNA: Formation, regulation and therapeutic potential	89
Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses	86
A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase	69
Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance	66
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B	63
Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes	59
Put a cork in it: Plugging the M2 viral ion channel to sink influenza	54

Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway	51
A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents	47
An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral	46
Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E	44
Benefit-risk assessment for brincidofovir for the treatment of smallpox: U.S. Food and Drug Administration's Evaluation	44
Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro	43
Immunoglobulin fragment F(ab’)2 against RBD potently neutralizes SARS-CoV-2 in vitro	43
Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2018–2020	43
Characterization of the antiviral effects of REP 2139 on the HBV lifecycle in vitro	41
Mechanisms of HBV immune evasion	40
Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses	39
Concerns about pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PK-PD) studies in the new therapeutic area of COVID-19 infection	39
Very low levels of remdesivir resistance in SARS-COV-2 genomes after 18 months of massive usage during the COVID19 pandemic: A GISAID exploratory analysis	39
Current understanding of human herpesvirus 6 (HHV-6) chromosomal integration	39
Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice	38
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection	37
Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies	37
Antiviral activity of the natural alkaloid anisomycin against dengue and Zika viruses	37
HBV replication inhibitors	35
An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection	34
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry	33
Antiviral activity of Apigenin against buffalopox: Novel mechanistic insights and drug-resistance considerations	33
Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development	33
Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2	32
Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir	32
Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system	32
Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo	32
Burden of influenza B virus infection and considerations for clinical management	32
A bacterial artificial chromosome (BAC)-vectored noninfectious replicon of SARS-CoV-2	31
Current knowledge on Hepatitis Delta Virus replication	31
Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry	30
Adoptive T-cell therapy for HBV-associated HCC and HBV infection	30
Alphavirus capsid protease inhibitors as potential antiviral agents for Chikungunya infection	30
Cinnamic acid inhibits Zika virus by inhibiting RdRp activity	29
Generation and characterization of Japanese encephalitis virus expressing GFP reporter gene for high throughput drug screening	28
Betulinic acid exhibits antiviral effects against dengue virus infection	28
HBV evolution and genetic variability: Impact on prevention, treatment and development of antivirals	28
Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway	27
In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs’ cleavage by CRISPR/Cas13a system	27
Artemisinin inhibits the replication of flaviviruses by promoting the type I interferon production	27
A synthetic STING agonist inhibits the replication of human parainfluenza virus 3 and rhinovirus 16 through distinct mechanisms	26
The rocaglate CR-31-B (−) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo	25
Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors	25
Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues	25
Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group	24
ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity	24
The chemokine receptor antagonist cenicriviroc inhibits the replication of SARS-CoV-2 in vitro	24
Allosteric inhibitors of the main protease of SARS-CoV-2	23
Effectiveness of pegylated interferon monotherapy in the treatment of chronic hepatitis D virus infection: A meta-analysis	23
Iminosugars: A host-targeted approach to combat Flaviviridae infections	22

Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation	22
Influenza A(H1N1)pdm09 virus exhibiting reduced susceptibility to baloxavir due to a PA E23K substitution detected from a child without baloxavir treatment	22
Methyl-β-cyclodextrin inhibits EV-D68 virus entry by perturbing the accumulation of virus particles and ICAM-5 in lipid rafts	22
Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro	22
The direct and indirect consequences of cytomegalovirus infection and potential benefits of vaccination	22
Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding	22
Antiviral drugs targeting endosomal membrane proteins inhibit distant animal and human pathogenic viruses	22
Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales	22
Efficacy of favipiravir (T-705) against Crimean-Congo hemorrhagic fever virus infection in cynomolgus macaques	21
Clinical outcome and the role of antivirals in congenital cytomegalovirus infection	21
Amide-containing α-hydroxytropolones as inhibitors of hepatitis B virus replication	21
Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model	21
Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors	20
Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway	20
Reasons to consider early treatment in chronic hepatitis B patients	20
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening	20
Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication	20
Antiviral activities of four marine sulfated glycans against adenovirus and human cytomegalovirus	20
Targeting host DEAD-box RNA helicase DDX3X for treating viral infections	20
Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking	19
Hepatoprotective, antioxidant, anti-inflammatory, and antiviral activities of silymarin against mayaro virus infection	19
Perspectives on stopping nucleos(t)ide analogues therapy in patients with chronic hepatitis B	19
Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target	19
COVID-19, Influenza and RSV: Surveillance-informed prevention and treatment – Meeting report from an isirv-WHO virtual conference	19
S-adenosylmethionine-dependent methyltransferase inhibitor DZNep blocks transcription and translation of SARS-CoV-2 genome with a low tendency to select for drug-resistant viral variants	18
A novel method to precisely quantify hepatitis B virus covalently closed circular (ccc)DNA formation and maintenance	18
New methylene blue derivatives suggest novel anti-orthopoxviral strategies	18
Repurposing Pyramax®, quinacrine and tilorone as treatments for Ebola virus disease	18
Prevention and treatment of neonatal herpes simplex virus infection	18
Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augm	18
14-Deoxy-11,12-didehydroandrographolide inhibits apoptosis in influenza A(H5N1) virus-infected human lung epithelial cells via the caspase-9-dependent intrinsic apoptotic pathway which contributes to	17
Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro	17
E3 ubiquitin ligase TRIM21 restricts hepatitis B virus replication by targeting HBx for proteasomal degradation	17
5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis	17
Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase	17
Influenza antivirals and their role in pandemic preparedness	17
MDA5 against enteric viruses through induction of interferon-like response partially via the JAK-STAT cascade	17
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies	17
A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera	16
Prophylaxis of ferrets with nitazoxanide and oseltamivir combinations is more effective at reducing the impact of influenza a virus infection compared to oseltamivir monotherapy	16
Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2	16
Failure to bictegravir and development of resistance mutations in an antiretroviral-experienced patient	16
Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening	16
Characterization of contemporary influenza B recombinant viruses harboring mutations of reduced susceptibility to baloxavir marboxil, in vitro and in mice	16
The novel therapeutic target and inhibitory effects of PF-429242 against Zika virus infection	15
Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein	15
Glibenclamide inhibits BK polyomavirus infection in kidney cells through CFTR blockade	15
Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir	15
Sofosbuvir shows a protective effect against vertical transmission of Zika virus and the associated congenital syndrome in rhesus monkeys	15
Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts	15
Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro	15
Next-generation sequencing for cytomegalovirus antiviral resistance genotyping in a clinical virology laboratory	15
A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by up regulation of type I interferon	15
Suppression effect of plant-derived berberine on cyprinid herpesvirus 2 proliferation and its pharmacokinetics in Crucian carp (Carassius auratus gibelio)	14
Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses	14
The influence of interferon-lambda on restricting Middle East Respiratory Syndrome Coronavirus replication in the respiratory epithelium	14
Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis	14
Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90	14
A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection	14
Detection of baloxavir resistant influenza A viruses using next generation sequencing and pyrosequencing methods	14
Substitution-inert polynuclear platinum compounds inhibit human cytomegalovirus attachment and entry	14
Vaccine strain of O/ME-SA/Ind-2001e of foot-and-mouth disease virus provides high immunogenicity and broad antigenic coverage	14
Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses	14
A human recombinant analogue to plasma-derived vaccinia immunoglobulin prophylactically and therapeutically protects against lethal orthopoxvirus challenge	14
Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs	14
Phenothiazines inhibit SARS-CoV-2 cell entry via a blockade of spike protein binding to neuropilin-1	14
NK-lysin peptides ameliorate viral encephalopathy and retinopathy disease signs and provide partial protection against nodavirus infection in European sea bass	14
Generation of a reporter yellow fever virus for high throughput antiviral assays	14
Conserved coronavirus proteins as targets of broad-spectrum antivirals	13
Identification of entry inhibitors with 4-aminopiperidine scaffold targeting group 1 influenza A virus	13
Anti-flavivirus activity of polyoxometalate	13
In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2	13
Duration of fever and symptoms in children after treatment with baloxavir marboxil and oseltamivir during the 2018–2019 season and detection of variant influenza a viruses with polymerase acidic subun	13
ACE2-Fc fusion protein overcomes viral escape by potently neutralizing SARS-CoV-2 variants of concern	13
Animal models for the study of human hepatitis B and D virus infection: New insights and progress	13
Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig	13
Target verification of artesunate-related antiviral drugs: Assessing the role of mitochondrial and regulatory proteins by click chemistry and fluorescence labeling	13
Enzymatically synthesized 2′-fluoro-modified Dicer-substrate siRNA swarms against herpes simplex virus demonstrate enhanced antiviral efficacy and low cytotoxicity	13
A dengue type 2 reporter virus assay amenable to high-throughput screening	13
Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier	13

Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines	12
Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3	12
The trimeric artesunate derivative TF27 exerts strong anti-cytomegaloviral efficacy: Focus on prophylactic efficacy and oral treatment of immunocompetent mice	12
Reverse genetic systems of SARS-CoV-2 for antiviral research	12
Acyclovir, cidofovir, and amenamevir have additive antiviral effects on herpes simplex virus TYPE 1	12
Potential application of antiviral coumarin in aquaculture against IHNV infection by reducing viral adhesion to the epithelial cell surface	12
Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients	12
Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors	12
Clinical and virological responses to a broad-spectrum human monoclonal antibody in an influenza virus challenge study	12
Immunobiology of Crimean-Congo hemorrhagic fever	12
Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2	12
Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors	12
Comparative pathology study of Venezuelan, eastern, and western equine encephalitis viruses in non-human primates	12
Functional neuraminidase inhibitor resistance motifs in avian influenza A(H5Nx) viruses	12
Immunodetection assays for the quantification of seasonal common cold coronaviruses OC43, NL63, or 229E infection confirm nirmatrelvir as broad coronavirus inhibitor	12
DDX3 inhibitors show antiviral activity against positive-sense single-stranded RNA viruses but not against negative-sense single-stranded RNA viruses: The coxsackie B model	12
LINCS dataset-based repositioning of rosiglitazone as a potential anti-human adenovirus drug	11
Small molecule inhibitors possibly targeting the rearrangement of Zika virus envelope protein	11
SOX9 represses hepatitis B virus replication through binding to HBV EnhII/Cp and inhibiting the promoter activity	11
Identification of a novel inhibitor targeting influenza A virus group 2 hemagglutinins	11
The NF-κB inhibitor, SC75741, is a novel antiviral against emerging tick-borne bandaviruses	11
Nirmatrelvir exerts distinct antiviral potency against different human coronaviruses	11
Multivalent DNA vaccine protects against genital herpes by T-cell immune induction in vaginal mucosa	11
Evaluation of antiviral drugs against newly emerged SARS-CoV-2 Omicron subvariants	11
Hepatitis D virus: Improving virological knowledge to develop new treatments	11
Infectious bronchitis virus: Identification of Gallus gallus APN high-affinity ligands with antiviral effects	11
Current status of silica-based nanoparticles as therapeutics and its potential as therapies against viruses	11
Loss of hepatitis D virus infectivity upon farnesyl transferase inhibitor treatment associates with increasing RNA editing rates revealed by a new RT-ddPCR method	11
A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency	11
Discovery of novel SARS-CoV-2 inhibitors targeting the main protease Mpro by virtual screenings and hit optimization	11
BX795 demonstrates potent antiviral benefits against herpes simplex Virus-1 infection of human cell lines	10
Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	10
The human α-defensin-derived peptide HD5(1–9) inhibits cellular attachment and entry of human cytomegalovirus	10
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein	10
A novel cell culture model reveals the viral interference during hepatitis B and C virus coinfection	10
Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species	10
GS-441524 inhibits African swine fever virus infection in vitro	10
Licochalcone A inhibits enterovirus A71 replication in vitro and in vivo	10
The discovery and development of filociclovir for the prevention and treatment of human cytomegalovirus-related disease	10
Identification of hepatitis B virus core protein residues critical for capsid assembly, pgRNA encapsidation and resistance to capsid assembly modulators	10
BIKE regulates dengue virus infection and is a cellular target for broad-spectrum antivirals	10
Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease	10