Antiviral Research

Article	Citations
RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination	114
Editorial Board	94
Editorial Board	78
Editorial Board	73
Corrigendum to “Crystal structure and cap binding analysis of the methyltransferase of langat virus” [Antivir. Res. 208 (2022) 105459]	69
Long-term and efficient inhibition of hepatitis B virus replication by AAV8-delivered artificial microRNAs	55
Editorial Board	53
Hepatitis C virus elimination: So close, so far?	52
Progress in novel delivery technologies to improve efficacy of therapeutic antibodies	50
Targeted inhibition of IGF2BP1 effectively suppresses HBV replication via an m6A-dependent manner	49
Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier	45
ITGA4 drives pathogenesis of flavivirus and inhibition of it protects mice against Japanese encephalitis virus infection	43
Assessment of the broad-spectrum host targeting antiviral efficacy of halofuginone hydrobromide in human airway, intestinal and brain organotypic models.	41
Novel inhibitors of HSV-1 protease effective in vitro and in vivo	41
Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models	41
Niclosamide inhibits the replication of highly pathogenic avian influenza A (H5Nx) viruses and antiviral-resistant mutants	41
Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study	41
Methyl rosmarinate is an allosteric inhibitor of SARS-CoV-2 3 CL protease as a potential candidate against SARS-cov-2 infection	38
Understanding HBV immunopathogenesis to inform future immune-based therapies	38
Long-term effects of peginterferon-based therapy versus nucleos(t)ide analogue monotherapy in non-cirrhotic HBeAg-positive chronic hepatitis B patients	37
Discovery and development of INNA-051, a TLR2/6 agonist for the prevention of complications resulting from viral respiratory infections	37
Chemical-induced degradation of PreS2 mutant surface antigen via the induction of microautophagy	37
Editorial Board	36
Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus	36
Novel strategy for Poxviridae prevention: Thermostable combined subunit vaccine patch with intense immune response	36

Berberine promotes K48-linked polyubiquitination of HNF4α, leading to the inhibition of HBV replication	34
Structural and quantitative comparison of viral infection-associated N-glycans in plasma from humans, pigs, and chickens: Greater similarity between humans and chickens than pigs	33
Ligand-based design of peptide entry inhibitors targeting the endosomal receptor binding site of filoviruses	30
Corrigendum to “Overview of gene editing strategies against HBV” [Antivir. Res. 247 (2026) 106355]	30
Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals	30
The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection	29
Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2	29
A mouse model of human-derived H10N3 influenza enables preclinical evaluation of antiviral efficacy	29
JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase	28
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies	27
Envelope protein residue E152 confers enhanced GAS6-dependent cell entry to the African Zika virus strain MR766	27
Clinical and experimental evidence for transplacental vertical transmission of flaviviruses	27
Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2	27
Chelerythrine chloride inhibits Zika virus infection by targeting the viral NS4B protein	27
N-arylpyrimidinamine (NAPA) compounds are broadly acting inhibitors of human cytomegalovirus infection and spread	27
Differential effects of antiretroviral HIV integrase inhibitors on vascular cell adhesion molecules	26
A mimetic peptide of ACE2 protects against SARS-CoV-2 infection and decreases pulmonary inflammation related to COVID-19	26
Potent inhibition of diverse Omicron sublineages by SARS-CoV-2 fusion-inhibitory lipopeptides	26
Does a detectable HCV RNA at the end of DAA therapy herald treatment failure?	26
Research Alliance for Veterinary Science and Biodefense BSL-3 Network (RAV3N): Report on network origin and phase I activities	26
Lack of resistance development during brincidofovir therapy in animal models of orthopoxvirus infection	25
Inhibition of Chikungunya virus early replication by intracellular nanoantibodies targeting nsP2 Epitope Rich Region	25
Bictegravir alters glucose tolerance in vivo and causes hepatic mitochondrial dysfunction	25
Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database (CHARMD)	25
Generation of a panel of mutants that are resistant to standard of care therapies in a clinically relevant strain of human cytomegalovirus for drug resistance profiling	25
Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results	25
Design, synthesis and biological evaluation of a novel series of conjugates of N1-(phosphonoalkyl)-1,2,3-triazoles and N3-benzyl-6-bromoquinazoline-2,4-diones with anti-RSV activity	25
Establishment of a robust rat hepatitis E virus fecal-oral infection model and validation for antiviral studies	25
Implications of the antiviral drug favipiravir on rabies immunoglobulin for post-exposure prophylaxis of rabies in mice model with category III-like exposures	25
Structural biology of flavivirus NS1 protein and its antibody complexes	24
Nirmatrelvir exerts distinct antiviral potency against different human coronaviruses	24
MβCD inhibits SFTSV entry by disrupting lipid raft structure of the host cells	24
Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery	24
Characterization of remdesivir resistance mutations in COVID-19 patients with various immunosuppressive diseases	23
Editorial Board	23
Therapeutic targeting of organelles for inhibition of Zika virus replication in neurons	23
Ensitrelvir treatment–emergent amino acid substitutions in SARS-CoV-2 3CLpro detected in the SCORPIO-SR phase 3 trial	23
HIV protease inhibitor attenuated astrocyte autophagy involvement in inflammation via p38 MAPK pathway	22
Avasimibe can cooperate with a DC-targeting and integration-deficient lentivector to induce stronger HBV specific T cytotoxic response by regulating cholesterol metabolism	22
Host factor DUSP5 potently inhibits dengue virus infection by modulating cytoskeleton rearrangement	22
Editorial Board	22
Biological characterization of AB-343, a novel and potent SARS-CoV-2 Mpro inhibitor with pan-coronavirus activity	21
The protease inhibitor Nirmatrelvir synergizes with inhibitors of GRP78 to suppress SARS-CoV-2 replication	21
Broad-spectrum antiviral activity of two structurally analogous CYP3A inhibitors against pathogenic human coronaviruses in vitro	21
Lung transcriptomics of K18-hACE2 mice highlights mechanisms and genes involved in the MVA-S vaccine-mediated immune response and protection against SARS-CoV-2 infection	21
High throughput profiling identified PA-L106R amino acid substitution in A(H1N1)pdm09 influenza virus that confers reduced susceptibility to baloxavir in vitro	21
Nucleotide analogues and mpox: Repurposing the repurposable	20
Targeting PI4KB and Src/Abl host kinases as broad-spectrum antiviral strategy: Myth or real opportunity?	20
Editorial Board	20
Eeyarestatin I, an inhibitor of the valosin-containing protein, exhibits potent virucidal activity against the flaviviruses	20

The diverse roles of peroxisomes in the interplay between viruses and mammalian cells	20
Antiviral effect of vesatolimod (GS-9620) against foot-and-mouth disease virus both in vitro and in vivo	20
NSUN2-mediated RNA m5C dysregulation links HBV infection to TFEB silencing and lysosomal impairment	20
Corrigendum to “A virus-like particle candidate vaccine based on CRISPR/Cas9 gene editing technology elicits broad-spectrum protection against SARS-CoV-2” [Antivir. Res. 225 (2024) 105854]	19
A spatiotemporally controlled recombinant cccDNA mouse model for studying HBV and developing drugs against the virus	19
Intranasal delivery of an adenovirus-vector vaccine co-expressing a modified spike protein and a genetic adjuvant confers lasting mucosal immunity against SARS-CoV-2	19
Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals	19
Molecular mechanisms of hepatitis B virus entry inhibition by a bile acid derivative INT-767 binding to the preS1 region	19
The anti-respiratory syncytial virus activity of biochemicals from Pyrola incarnata	19
Interim analysis of the PARADISE study: Benefits of add-on peginterferon-α in NA-treated patients with CHB	19
LAVR-289, a broad-spectrum antiviral, protects immunosuppressed Syrian hamsters against lethal adenovirus challenge	18
Virus infection and sphingolipid metabolism	18
Targeting the host transcription factor HSF1 prevents human cytomegalovirus replication in vitro and in vivo	18
Flexible nano-liposomes-encapsulated recombinant UL8-siRNA (r/si-UL8) based on bioengineering strategy inhibits herpes simplex virus-1 infection	18
Elevated soluble LAG-3 in chronic hepatitis B and T-cell responses to checkpoint blockade	18
Performance of sofosbuvir and NITD008 in extrahepatic neuronal cells against HEV	18
Lipid-targeting antiviral strategies: Current state and future perspectives	18
Large-scale deep learning identifies the antiviral potential of PKI-179 and MTI-31 against coronaviruses	18
Development of a rapid image-based high-content imaging screening assay to evaluate therapeutic antibodies against the monkeypox virus	17
Antigenic mapping of enterovirus A71 from Taiwan and Southeast Asia	17
Induction of neutralizing antibodies and mucosal IgA through intranasal immunization with the receptor binding domain of SARS-CoV-2 spike protein fused with the type IIb E. coli heat-labile enterotoxi	17
Editorial Board	17
Porcine interferon-α linked to the porcine IgG-Fc induces prolonged and broad-spectrum antiviral effects against foot-and-mouth disease virus	17
Editorial Board	17
New technologies in therapeutic antibody development: The next frontier for treating infectious diseases	17
The lack of HBsAg secretion does neither facilitate induction of antiviral T cell responses nor Hepatitis B Virus clearance in mice	17
Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants	17
Editorial Board	17
Intranasal exposure to commensal bacterium Rothia mucilaginosa protects against influenza A virus infection	17
Targeting sgRNA N secondary structure as a way of inhibiting SARS-CoV-2 replication	17
Structural and mechanistic insight into the phosphorylation reaction catalyzed by mpox virus thymidine kinase	17
RNA virus infections and their effect on host alternative splicing	17
Editorial Board	16
Construction of a recombinant African swine fever virus with firefly luciferase and eGFP reporter genes and its application in high-throughput antiviral drug screening	16
Astersaponin I from Aster koraiensis is a natural viral fusion blocker that inhibits the infection of SARS-CoV-2 variants and syncytium formation	16
Identification of a surface-accessible tegument protein bearing a neutralizing epitope in varicella-zoster virus	16
Identification of alpha-linolenic acid as a broad-spectrum antiviral against zika, dengue, herpes simplex, influenza virus and SARS-CoV-2 infection	16
Development of a novel minigenome and recombinant VSV expressing Seoul hantavirus glycoprotein-based assays to identify anti-hantavirus therapeutics	16
Antiviral drug discovery with an optimized biochemical dengue protease assay: Improved predictive power for antiviral efficacy	16
Cold-adapted influenza vaccine carrying three repeats of a respiratory syncytial virus (RSV) fusion glycoprotein epitope site protects BALB/c mice and cotton rats against RSV infection	16
Design and synthesis of a new series of hybrids of functionalised N1-[(1H-1,2,3-triazol-4-yl)methyl]quinazoline-2,4-dione with antiviral activity against Respiratory Syncytial Virus	16
Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model	15
GS-1 blocks entry of herpes viruses and more broadly inhibits enveloped viruses	15
Three in one: An effective and universal vaccine expressing heterologous tandem RBD trimer by rabies virus vector protects mice against SARS-CoV-2	15
Editorial Board	15
Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy	15
CDK4/6 inhibitor palbociclib promotes SARS-CoV-2 cell entry by down-regulating SKP2 dependent ACE2 degradation	15
Editorial Board	15
The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants	15
Deubiquitinase USP39 promotes SARS-CoV-2 replication by deubiquitinating and stabilizing the envelope protein	14
Coronavirus nucleocapsid-based vaccine provides partial protection against hetero-species coronavirus in murine models	14
High-throughput drug screen identifies calcium and calmodulin inhibitors that reduce JCPyV infection	14
Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication	14
Identification of West Nile virus RNA-dependent RNA polymerase non-nucleoside inhibitors by real-time high throughput fluorescence screening	14
Retrospective analysis of steatosis effect on antiviral response and hepatocellular carcinoma risk in chronic hepatitis C	14
Potent in vitro antiviral activity of 4′-Fluorouridine against diverse orthohantaviruses including Andes virus	14
The host-targeted antiviral drug Zapnometinib exhibits a high barrier to the development of SARS-CoV-2 resistance	14
Current and future use of antibody-based passive immunity to prevent or control HBV/HDV infections	14
Isochlorogenic acid A impairs hepatitis B virus replication by interference with various steps of hepatitis B virus life cycle involving HO-1-mediated ROS modulation	14
History and impact of the mouse-adapted Ebola virus model	14
Antiviral strategies against human metapneumovirus: Targeting the fusion protein	14
A novel cellular tool for screening human pan-coronavirus antivirals	13
Exploiting host kinases to combat dengue virus infection and disease	13
Editorial Board	13
Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus	13
Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication	13
Editorial Board	13
Induction of antiviral gene expression by cyclosporine A, but not inhibition of cyclophilin A or B, contributes to its restriction of human coronavirus 229E infection in a lung epithelial cell line	13
Porcine epidemic diarrhea virus infection activates SREBP2 and induces RORγ expression to enhance cholesterol biosynthesis and virus replication	13
Editorial Board	13
Editorial Board	13
Evaluation of panel of neutralising murine monoclonal antibodies and a humanised bispecific antibody against influenza A(H1N1)pdm09 virus infection in a mouse model	13
Insights on the antiviral mechanisms of action of the TLR1/2 agonist Pam3CSK4 in hepatitis B virus (HBV)-infected hepatocytes	13
HDV sensing drives USP18-mediated refractoriness to IFN-α response, sparing IFN-β/λ in hepatocytes	13
PRO-2000 exhibits SARS-CoV-2 antiviral activity by interfering with spike-heparin binding	13
JC polyomavirus-encoded miRNA jcv-miR-J1-5p downregulates BK polyomavirus infection	13
Expanding the anti-flaviviral arsenal: Discovery of a baicalein-derived Compound with potent activity against DENV and ZIKV.	12
Harnessing T4 phage-based platform for efficient design of ready-to-use multiepitope vaccines	12
Optimization of Bangladesh and Malaysian genotype recombinant reporter Nipah viruses for in vitro antiviral screening and in vivo disease modeling	12
Discovery of broad-spectrum antivirals targeting viral proteases using in silico structural modeling and cellular analysis	12

Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome	12
Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus	12
Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants	12
Salicylamide derivative JMX0312 protects immunosuppressed Syrian hamsters against adenovirus lethal challenge	12
Editorial Board	12
Effect of E23G/K, F36V, N37T, E119D, and E199G polymerase acidic protein substitutions on the replication and baloxavir susceptibility of influenza B viruses	12
Evaluation of pharmacokinetics of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil (TDF) in pregnant and postpartum women in South Africa: PrEP-PP PK study	12
Antisense oligonucleotides as drugs with both direct and indirect antiviral actions	12
25R,26-hydroxycholesterol and an oxysterol synthetic analog inhibit Varicella zoster Virus replication	12
Influenza antivirals and their role in pandemic preparedness	12
Substitutions M478K and A482G in the polymerase of yellow fever virus confer resistance to sofosbuvir and uprifosbuvir in vitro	12
Overview of gene editing strategies against HBV	12
Mechanisms of action of repurposed Ebola virus antivirals – the roles of phospholipidosis and cholesterol homeostasis	12
Marburg and Kasokero viruses elicit differential antiviral innate immune control by their natural reservoir bat, the Egyptian rousette (Rousettus aegyptiacus)	12
Effect of antivirals on clinical and lab-adapted human cytomegalovirus strains using induced pluripotent stem cell-derived human neural models	12
Screening of an epigenetic compound library identifies BRD4 as a potential antiviral target for hepatitis B virus covalently closed circular DNA transcription	11
α7 nicotinic receptor activation mitigates herpes simplex virus type 1 infection in microglia cells	11
Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate	11
Editorial Board	11
Pinostrobin from plants and propolis against human coronavirus HCoV-OC43 by modulating host AHR/CYP1A1 pathway and lipid metabolism	11
Efficacy of an Fc-silent antibody targeting the apical domain of human transferrin receptor 1 in transgenic mouse models of Junín virus infection	11
Cathepsin inhibitors nitroxoline and its derivatives inhibit SARS-CoV-2 infection	11
Activation of cGAS-STING suppresses coxsackievirus replication via interferon-dependent signaling	11
β-d-N4-hydroxycytidine, a metabolite of molnupiravir, exhibits in vitro antiviral activity against rabies virus	11
Targeting of the cellular ATM rather than ATR kinase exhibits therapeutic potential during the lumpy skin disease virus infection in vivo and in vitro	11
Recombinant pseudorabies virus (PRV) expressing stabilized E2 of classical swine fever virus (CSFV) protects against both PRV and CSFV	11
Inhibitors of pyrimidine synthesis synergize with N4-hydroxycytidine to diminish influenza virus replication	11
Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains	11
Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening	11
Antiviral mechanisms and preclinical evaluation of amantadine analogs that continue to inhibit influenza A viruses with M2S31N-based drug resistance	11
Receptor recognition of hepatitis B and D viruses: Structural insight and its application to drug discovery	11
β-D-N4-hydroxycytidine (NHC, EIDD-1931) inhibits chikungunya virus replication in mosquito cells and ex vivo Aedes aegypti guts, but not when ingested during blood-feeding	11
The ApoA1-mimetic peptide 4F blocks flavivirus NS1-triggered endothelial dysfunction and protects against lethal dengue virus challenge	11
RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5ʹ-untranslated region	11
Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus	11
Dynamic features of virus protein 1 and substitutions in the 3-phenyl ring determine the potency and broad-spectrum activity of capsid-binding pyrazolo[3,4-d]pyrimidines against rhinoviruses	11
Verteporfin is a broad-spectrum inhibitor of arboviruses and influences viral and host-based events	11
Tissue replication and mucosal swab detection of Sosuga virus in Syrian hamsters in the absence of overt tissue pathology and clinical disease	11
Evaluation of a novel severe combined immunodeficiency mouse model for antiviral drug evaluation against Chandipura virus infection	10
New insights into the neuraminidase-mediated hemagglutination activity of influenza A(H3N2) viruses	10
Functional assessments of SARS-CoV-2 single-round infectious particles with variant-specific spike proteins on infectivity, drug sensitivity, and antibody neutralization	10
Pathogenicity and antiviral treatment of clade Ib Monkeypox virus infection in mice	10
SARS-CoV-2 resistance analyses from the Phase 3 OAKTREE study of obeldesivir in low-risk nonhospitalized participants with COVID-19	10
Identification of oxysterol synthetic analogs as a novel class of late-stage inhibitors of herpes simplex virus 2 replication	10
KDM5A/B contribute to HIV-1 latent infection and survival of HIV-1 infected cells	10
Human monoclonal antibodies from donors vaccinated with recombinant vaccinia vaccine targeting A35 and B6 effectively inhibit orthopoxvirus spread and infection	10
Characterization of clinical envelopes with lack of sensitivity to the HIV-1 inhibitors temsavir and ibalizumab	10
Lapachol, a dihydroorotate dehydrogenase inhibitor, demonstrates antiviral activity against feline calicivirus in vitro and in vivo	10
Low antiviral resistance in Influenza A and B viruses isolated in Mexico from 2010 to 2023	10
Characterization of SARS-CoV-2 replication in human H1299/ACE2 cells: A versatile and practical infection model for antiviral research and beyond	10
Small molecule direct-acting antivirals for treatment of mpox	10
Antiviral drugs block replication of highly immune-evasive Omicron subvariants ex vivo, but fail to reduce tissue inflammation	10
Editorial Board	10
Assessment of CMV infection in allo-HSCT recipients undergoing LMV prophylaxis by using an implemented diagnostic protocol to identify active viral replication	10
Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro	10
Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: Blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the vira	10
A bivalent form of a RBD-specific synthetic antibody effectively neutralizes SARS-CoV-2 variants	10
5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro	10
Vemurafenib inhibits the replication of diabetogenic enteroviruses in intestinal epithelial and pancreatic beta cells	10
Viral sequence analysis of chronic hepatitis B patients treated with the capsid assembly modulator JNJ-56136379 in the JADE phase 2a study	10
Preclinical efficacy of a favipiravir and nitazoxanide combination against Rift Valley Fever Virus	10
Porcine CD161 promotes Japanese encephalitis virus entry: a potential host-directed antiviral target	10
Cholesterol 25-hydroxylase inhibits Newcastle disease virus replication by its architectural damage and blocking HN protein	10
Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication	10
Cyclic lipopeptides as membrane fusion inhibitors against SARS-CoV-2: New tricks for old dogs	10