Antiviral Research

Article	Citations
Editorial Board	357
Editorial Board	97
RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination	93
Editorial Board	75
Development of cell culture infectious clones for hepatitis C virus genotype 1b and transcription analysis of 1b-infected hepatoma cells	63
Long-term and efficient inhibition of hepatitis B virus replication by AAV8-delivered artificial microRNAs	59
Editorial Board	59
Progress in novel delivery technologies to improve efficacy of therapeutic antibodies	56
Novel inhibitors of HSV-1 protease effective in vitro and in vivo	54
Corrigendum to “Crystal structure and cap binding analysis of the methyltransferase of langat virus” [Antivir. Res. 208 (2022) 105459]	54
Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro	53
Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models	53
A novel model based on qAnti-HBc and conventional biomarkers for identifying significant liver injury among CHB patients with ALT ≤ ULN	48
Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier	43
Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study	43
A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy	39
Comparison of the effects of different potent adjuvants on enhancing the immunogenicity and cross-protection by influenza virus vaccination in young and aged mice	39
Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2	35
Assessment of the broad-spectrum host targeting antiviral efficacy of halofuginone hydrobromide in human airway, intestinal and brain organotypic models.	35
Berberine promotes K48-linked polyubiquitination of HNF4α, leading to the inhibition of HBV replication	35
Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus	34
A novel high-throughput single B-cell cloning platform for isolation and characterization of high-affinity and potent SARS-CoV-2 neutralizing antibodies	33
Methyl rosmarinate is an allosteric inhibitor of SARS-CoV-2 3 CL protease as a potential candidate against SARS-cov-2 infection	33
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection	32
Structural and quantitative comparison of viral infection-associated N-glycans in plasma from humans, pigs, and chickens: Greater similarity between humans and chickens than pigs	32

Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals	31
Ligand-based design of peptide entry inhibitors targeting the endosomal receptor binding site of filoviruses	31
Corrigendum to “The novel therapeutic target and inhibitory effects of PF-429242 against Zika virus infection” [Antivir. Res. vol 192 (2021) 1–13/105121]	29
JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase	29
Discovery and development of INNA-051, a TLR2/6 agonist for the prevention of complications resulting from viral respiratory infections	29
Novel strategy for Poxviridae prevention: Thermostable combined subunit vaccine patch with intense immune response	29
The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection	29
Editorial Board	28
Chemical-induced degradation of PreS2 mutant surface antigen via the induction of microautophagy	27
Implications of the antiviral drug favipiravir on rabies immunoglobulin for post-exposure prophylaxis of rabies in mice model with category III-like exposures	26
Identification of novel Ebola virus inhibitors using biologically contained virus	26
Ergosterol peroxide inhibits HBV infection by inhibiting the binding of the pre-S1 domain of LHBsAg to NTCP	26
Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model	26
Potent inhibition of diverse Omicron sublineages by SARS-CoV-2 fusion-inhibitory lipopeptides	25
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies	24
Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2	24
Ensitrelvir treatment–emergent amino acid substitutions in SARS-CoV-2 3CLpro detected in the SCORPIO-SR phase 3 trial	24
Inhibition of Chikungunya virus early replication by intracellular nanoantibodies targeting nsP2 Epitope Rich Region	24
Therapeutic targeting of organelles for inhibition of Zika virus replication in neurons	23
Next-generation sequencing for cytomegalovirus antiviral resistance genotyping in a clinical virology laboratory	23
Bictegravir alters glucose tolerance in vivo and causes hepatic mitochondrial dysfunction	23
Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database (CHARMD)	23
MβCD inhibits SFTSV entry by disrupting lipid raft structure of the host cells	22
A mimetic peptide of ACE2 protects against SARS-CoV-2 infection and decreases pulmonary inflammation related to COVID-19	22
High dose sofosbuvir and sofosbuvir-plus-ribavirin therapy inhibit Hepatitis E Virus (HEV) replication in a rabbit model for acute HEV infection	22
Research Alliance for Veterinary Science and Biodefense BSL-3 Network (RAV3N): Report on network origin and phase I activities	22
Structural biology of flavivirus NS1 protein and its antibody complexes	21
Nirmatrelvir exerts distinct antiviral potency against different human coronaviruses	21
Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results	21
Establishment of a robust rat hepatitis E virus fecal-oral infection model and validation for antiviral studies	21
N-arylpyrimidinamine (NAPA) compounds are broadly acting inhibitors of human cytomegalovirus infection and spread	20
Chelerythrine chloride inhibits Zika virus infection by targeting the viral NS4B protein	20
Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery	20
Clinical and experimental evidence for transplacental vertical transmission of flaviviruses	20
Virus infection and sphingolipid metabolism	19
Does a detectable HCV RNA at the end of DAA therapy herald treatment failure?	19
Eeyarestatin I, an inhibitor of the valosin-containing protein, exhibits potent virucidal activity against the flaviviruses	19
Flexible nano-liposomes-encapsulated recombinant UL8-siRNA (r/si-UL8) based on bioengineering strategy inhibits herpes simplex virus-1 infection	19
Interim analysis of the PARADISE study: Benefits of add-on peginterferon-α in NA-treated patients with CHB	19
Sulfated β-glucan from Agaricus subrufescens inhibits flavivirus infection and nonstructural protein 1-mediated pathogenesis	19
Intranasal exposure to commensal bacterium Rothia mucilaginosa protects against influenza A virus infection	18
Targeting PI4KB and Src/Abl host kinases as broad-spectrum antiviral strategy: Myth or real opportunity?	18
Lung transcriptomics of K18-hACE2 mice highlights mechanisms and genes involved in the MVA-S vaccine-mediated immune response and protection against SARS-CoV-2 infection	18
Host factor DUSP5 potently inhibits dengue virus infection by modulating cytoskeleton rearrangement	18
Biological characterization of AB-343, a novel and potent SARS-CoV-2 Mpro inhibitor with pan-coronavirus activity	18
Antiviral effect of vesatolimod (GS-9620) against foot-and-mouth disease virus both in vitro and in vivo	18
Editorial Board	18
Large-scale deep learning identifies the antiviral potential of PKI-179 and MTI-31 against coronaviruses	18
High throughput profiling identified PA-L106R amino acid substitution in A(H1N1)pdm09 influenza virus that confers reduced susceptibility to baloxavir in vitro	18
Editorial Board	18

The diverse roles of peroxisomes in the interplay between viruses and mammalian cells	17
A spatiotemporally controlled recombinant cccDNA mouse model for studying HBV and developing drugs against the virus	17
Potential application of antiviral coumarin in aquaculture against IHNV infection by reducing viral adhesion to the epithelial cell surface	17
Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals	17
Performance of sofosbuvir and NITD008 in extrahepatic neuronal cells against HEV	17
Intranasal delivery of an adenovirus-vector vaccine co-expressing a modified spike protein and a genetic adjuvant confers lasting mucosal immunity against SARS-CoV-2	17
Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway	17
Viral replicon particles protect IFNAR−/− mice against lethal Crimean-Congo hemorrhagic fever virus challenge three days after vaccination	16
The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters	16
Nucleotide analogues and mpox: Repurposing the repurposable	16
Lipid-targeting antiviral strategies: Current state and future perspectives	16
Targeting the host transcription factor HSF1 prevents human cytomegalovirus replication in vitro and in vivo	16
Astersaponin I from Aster koraiensis is a natural viral fusion blocker that inhibits the infection of SARS-CoV-2 variants and syncytium formation	15
Antigenic mapping of enterovirus A71 from Taiwan and Southeast Asia	15
HIV protease inhibitor attenuated astrocyte autophagy involvement in inflammation via p38 MAPK pathway	15
Editorial Board	15
Editorial Board	15
Induction of neutralizing antibodies and mucosal IgA through intranasal immunization with the receptor binding domain of SARS-CoV-2 spike protein fused with the type IIb E. coli heat-labile enterotoxi	15
Avasimibe can cooperate with a DC-targeting and integration-deficient lentivector to induce stronger HBV specific T cytotoxic response by regulating cholesterol metabolism	15
Antiviral drug discovery with an optimized biochemical dengue protease assay: Improved predictive power for antiviral efficacy	15
Broad-spectrum antiviral activity of two structurally analogous CYP3A inhibitors against pathogenic human coronaviruses in vitro	15
Hemin protects against Zika virus infection by disrupting virus-endosome fusion	14
Porcine interferon-α linked to the porcine IgG-Fc induces prolonged and broad-spectrum antiviral effects against foot-and-mouth disease virus	14
Construction of a recombinant African swine fever virus with firefly luciferase and eGFP reporter genes and its application in high-throughput antiviral drug screening	14
Homoseongomycin, a compound isolated from marine actinomycete bacteria K3-1, is a potent inhibitor of encephalitic alphaviruses	14
Niclosamide inhibits hepatitis E virus through suppression of NF-kappaB signalling	14
Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants	14
Development of a rapid image-based high-content imaging screening assay to evaluate therapeutic antibodies against the monkeypox virus	14
A recombinant Cedar virus based high-throughput screening assay for henipavirus antiviral discovery	14
Targeting sgRNA N secondary structure as a way of inhibiting SARS-CoV-2 replication	14
RNA virus infections and their effect on host alternative splicing	14
Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group	14
New technologies in therapeutic antibody development: The next frontier for treating infectious diseases	14
Design and synthesis of a new series of hybrids of functionalised N1-[(1H-1,2,3-triazol-4-yl)methyl]quinazoline-2,4-dione with antiviral activity against Respiratory Syncytial Virus	14
Differential expression of HIV envelope epitopes on the surface of HIV-Infected macrophages and CD4+ T cells	14
Identification of alpha-linolenic acid as a broad-spectrum antiviral against zika, dengue, herpes simplex, influenza virus and SARS-CoV-2 infection	14
The lack of HBsAg secretion does neither facilitate induction of antiviral T cell responses nor Hepatitis B Virus clearance in mice	14
Structural and mechanistic insight into the phosphorylation reaction catalyzed by mpox virus thymidine kinase	14
Current and future use of antibody-based passive immunity to prevent or control HBV/HDV infections	13
Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication	13
Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model	13
The host-targeted antiviral drug Zapnometinib exhibits a high barrier to the development of SARS-CoV-2 resistance	13
Editorial Board	13
Coronavirus nucleocapsid-based vaccine provides partial protection against hetero-species coronavirus in murine models	13
Development of a novel minigenome and recombinant VSV expressing Seoul hantavirus glycoprotein-based assays to identify anti-hantavirus therapeutics	13
History and impact of the mouse-adapted Ebola virus model	13
Screening and identification of Lassa virus endonuclease-targeting inhibitors from a fragment-based drug discovery library	13
Three in one: An effective and universal vaccine expressing heterologous tandem RBD trimer by rabies virus vector protects mice against SARS-CoV-2	13
Editorial Board	13
Identification of West Nile virus RNA-dependent RNA polymerase non-nucleoside inhibitors by real-time high throughput fluorescence screening	13
CDK4/6 inhibitor palbociclib promotes SARS-CoV-2 cell entry by down-regulating SKP2 dependent ACE2 degradation	13
GS-1 blocks entry of herpes viruses and more broadly inhibits enveloped viruses	13
High-throughput drug screen identifies calcium and calmodulin inhibitors that reduce JCPyV infection	13
Editorial Board	13
Cold-adapted influenza vaccine carrying three repeats of a respiratory syncytial virus (RSV) fusion glycoprotein epitope site protects BALB/c mice and cotton rats against RSV infection	12
Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy	12
RNA-Binding motif protein 38 (RBM38) mediates HBV pgRNA packaging into the nucleocapsid	12
Induction of antiviral gene expression by cyclosporine A, but not inhibition of cyclophilin A or B, contributes to its restriction of human coronavirus 229E infection in a lung epithelial cell line	12
Baseline serum hepatitis B core antibody level predicts HBeAg seroconversion in patients with HBeAg-positive chronic hepatitis B after antiviral treatment	12
Antiviral strategies against human metapneumovirus: Targeting the fusion protein	12
Deubiquitinase USP39 promotes SARS-CoV-2 replication by deubiquitinating and stabilizing the envelope protein	12
PRO-2000 exhibits SARS-CoV-2 antiviral activity by interfering with spike-heparin binding	12
25R,26-hydroxycholesterol and an oxysterol synthetic analog inhibit Varicella zoster Virus replication	12
The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants	12
Evaluation of panel of neutralising murine monoclonal antibodies and a humanised bispecific antibody against influenza A(H1N1)pdm09 virus infection in a mouse model	12
Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication	12
Editorial Board	12
Optimization of Bangladesh and Malaysian genotype recombinant reporter Nipah viruses for in vitro antiviral screening and in vivo disease modeling	11
Nafamostat mesylate as a broad-spectrum candidate for the treatment of flavivirus infections by targeting envelope proteins	11
Antiviral mechanisms and preclinical evaluation of amantadine analogs that continue to inhibit influenza A viruses with M2S31N-based drug resistance	11
CD47 expression attenuates Ebola virus-induced immunopathology in mice	11
Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants	11
Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus	11
Insights on the antiviral mechanisms of action of the TLR1/2 agonist Pam3CSK4 in hepatitis B virus (HBV)-infected hepatocytes	11
Expanding the anti-flaviviral arsenal: Discovery of a baicalein-derived Compound with potent activity against DENV and ZIKV.	11
Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus	11
Influenza antivirals and their role in pandemic preparedness	11
Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening	10
Editorial Board	10
Editorial Board	10

Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome	10
Dynamic features of virus protein 1 and substitutions in the 3-phenyl ring determine the potency and broad-spectrum activity of capsid-binding pyrazolo[3,4-d]pyrimidines against rhinoviruses	10
Tissue replication and mucosal swab detection of Sosuga virus in Syrian hamsters in the absence of overt tissue pathology and clinical disease	10
Inhibitory effect of a novel thiazolidinedione derivative on hepatitis B virus entry	10
RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5ʹ-untranslated region	10
Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus	10
Activation of cGAS-STING suppresses coxsackievirus replication via interferon-dependent signaling	10
Editorial Board	10
Effect of E23G/K, F36V, N37T, E119D, and E199G polymerase acidic protein substitutions on the replication and baloxavir susceptibility of influenza B viruses	10
Association of C-reactive protein polymorphisms with serum-CRP concentration and viral load among dengue-chikungunya mono/co-infected patients	10
Evaluation of pharmacokinetics of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil (TDF) in pregnant and postpartum women in South Africa: PrEP-PP PK study	10
Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains	10
Licochalcone A inhibits enterovirus A71 replication in vitro and in vivo	10
Screening of an epigenetic compound library identifies BRD4 as a potential antiviral target for hepatitis B virus covalently closed circular DNA transcription	10
Cathepsin inhibitors nitroxoline and its derivatives inhibit SARS-CoV-2 infection	10
Recombinant pseudorabies virus (PRV) expressing stabilized E2 of classical swine fever virus (CSFV) protects against both PRV and CSFV	10
Novel quinolone derivatives targeting human dihydroorotate dehydrogenase suppress Ebola virus infection in vitro	10
β-d-N4-hydroxycytidine, a metabolite of molnupiravir, exhibits in vitro antiviral activity against rabies virus	10
The calcium channel inhibitor lacidipine inhibits Zika virus replication in neural progenitor cells	10
Vemurafenib inhibits the replication of diabetogenic enteroviruses in intestinal epithelial and pancreatic beta cells	9
Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors	9
KDM5A/B contribute to HIV-1 latent infection and survival of HIV-1 infected cells	9
Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication	9
A screen of FDA-approved drugs with minigenome identified tigecycline as an antiviral targeting nucleoprotein of Crimean-Congo hemorrhagic fever virus	9
5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro	9
New insights into the neuraminidase-mediated hemagglutination activity of influenza A(H3N2) viruses	9
Low antiviral resistance in Influenza A and B viruses isolated in Mexico from 2010 to 2023	9
Editorial Board	9
Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate	9
The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs	9
Identification of oxysterol synthetic analogs as a novel class of late-stage inhibitors of herpes simplex virus 2 replication	9
Characterization of SARS-CoV-2 replication in human H1299/ACE2 cells: A versatile and practical infection model for antiviral research and beyond	9
A bivalent form of a RBD-specific synthetic antibody effectively neutralizes SARS-CoV-2 variants	9
The ApoA1-mimetic peptide 4F blocks flavivirus NS1-triggered endothelial dysfunction and protects against lethal dengue virus challenge	9
β-D-N4-hydroxycytidine (NHC, EIDD-1931) inhibits chikungunya virus replication in mosquito cells and ex vivo Aedes aegypti guts, but not when ingested during blood-feeding	9
Characterization of clinical envelopes with lack of sensitivity to the HIV-1 inhibitors temsavir and ibalizumab	9
Editorial Board	9
Cinnamic acid inhibits Zika virus by inhibiting RdRp activity	9