Antiviral Research

Article	Citations
RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination	101
Editorial Board	88
Editorial Board	70
Editorial Board	66
Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study	63
Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier	53
Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models	46
A novel model based on qAnti-HBc and conventional biomarkers for identifying significant liver injury among CHB patients with ALT ≤ ULN	46
Corrigendum to “Crystal structure and cap binding analysis of the methyltransferase of langat virus” [Antivir. Res. 208 (2022) 105459]	44
Progress in novel delivery technologies to improve efficacy of therapeutic antibodies	43
Editorial Board	41
Hepatitis C virus elimination: So close, so far?	40
Novel inhibitors of HSV-1 protease effective in vitro and in vivo	39
Long-term and efficient inhibition of hepatitis B virus replication by AAV8-delivered artificial microRNAs	38
Targeted inhibition of IGF2BP1 effectively suppresses HBV replication via an m6A-dependent manner	38
Assessment of the broad-spectrum host targeting antiviral efficacy of halofuginone hydrobromide in human airway, intestinal and brain organotypic models.	37
Discovery and development of INNA-051, a TLR2/6 agonist for the prevention of complications resulting from viral respiratory infections	37
Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus	36
Editorial Board	36
Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals	36
The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection	36
Berberine promotes K48-linked polyubiquitination of HNF4α, leading to the inhibition of HBV replication	36
Chemical-induced degradation of PreS2 mutant surface antigen via the induction of microautophagy	36
JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase	35
Long-term effects of peginterferon-based therapy versus nucleos(t)ide analogue monotherapy in non-cirrhotic HBeAg-positive chronic hepatitis B patients	31

Methyl rosmarinate is an allosteric inhibitor of SARS-CoV-2 3 CL protease as a potential candidate against SARS-cov-2 infection	29
Ligand-based design of peptide entry inhibitors targeting the endosomal receptor binding site of filoviruses	29
Novel strategy for Poxviridae prevention: Thermostable combined subunit vaccine patch with intense immune response	28
A novel high-throughput single B-cell cloning platform for isolation and characterization of high-affinity and potent SARS-CoV-2 neutralizing antibodies	27
Structural and quantitative comparison of viral infection-associated N-glycans in plasma from humans, pigs, and chickens: Greater similarity between humans and chickens than pigs	27
Does a detectable HCV RNA at the end of DAA therapy herald treatment failure?	27
Generation of a panel of mutants that are resistant to standard of care therapies in a clinically relevant strain of human cytomegalovirus for drug resistance profiling	26
Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results	26
Implications of the antiviral drug favipiravir on rabies immunoglobulin for post-exposure prophylaxis of rabies in mice model with category III-like exposures	26
Inhibition of Chikungunya virus early replication by intracellular nanoantibodies targeting nsP2 Epitope Rich Region	26
Research Alliance for Veterinary Science and Biodefense BSL-3 Network (RAV3N): Report on network origin and phase I activities	26
Potent inhibition of diverse Omicron sublineages by SARS-CoV-2 fusion-inhibitory lipopeptides	25
A mimetic peptide of ACE2 protects against SARS-CoV-2 infection and decreases pulmonary inflammation related to COVID-19	25
Chelerythrine chloride inhibits Zika virus infection by targeting the viral NS4B protein	25
Clinical and experimental evidence for transplacental vertical transmission of flaviviruses	24
Therapeutic targeting of organelles for inhibition of Zika virus replication in neurons	24
Bictegravir alters glucose tolerance in vivo and causes hepatic mitochondrial dysfunction	24
Design, synthesis and biological evaluation of a novel series of conjugates of N1-(phosphonoalkyl)-1,2,3-triazoles and N3-benzyl-6-bromoquinazoline-2,4-diones with anti-RSV activity	24
Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database (CHARMD)	24
Differential effects of antiretroviral HIV integrase inhibitors on vascular cell adhesion molecules	24
Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery	23
Ensitrelvir treatment–emergent amino acid substitutions in SARS-CoV-2 3CLpro detected in the SCORPIO-SR phase 3 trial	23
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies	23
MβCD inhibits SFTSV entry by disrupting lipid raft structure of the host cells	23
Nirmatrelvir exerts distinct antiviral potency against different human coronaviruses	23
Structural biology of flavivirus NS1 protein and its antibody complexes	23
Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2	23
Establishment of a robust rat hepatitis E virus fecal-oral infection model and validation for antiviral studies	23
Lack of resistance development during brincidofovir therapy in animal models of orthopoxvirus infection	23
Editorial Board	22
Nucleotide analogues and mpox: Repurposing the repurposable	22
N-arylpyrimidinamine (NAPA) compounds are broadly acting inhibitors of human cytomegalovirus infection and spread	22
Flexible nano-liposomes-encapsulated recombinant UL8-siRNA (r/si-UL8) based on bioengineering strategy inhibits herpes simplex virus-1 infection	22
Characterization of remdesivir resistance mutations in COVID-19 patients with various immunosuppressive diseases	22
Targeting the host transcription factor HSF1 prevents human cytomegalovirus replication in vitro and in vivo	22
Intranasal delivery of an adenovirus-vector vaccine co-expressing a modified spike protein and a genetic adjuvant confers lasting mucosal immunity against SARS-CoV-2	21
The protease inhibitor Nirmatrelvir synergizes with inhibitors of GRP78 to suppress SARS-CoV-2 replication	21
High throughput profiling identified PA-L106R amino acid substitution in A(H1N1)pdm09 influenza virus that confers reduced susceptibility to baloxavir in vitro	21
Editorial Board	21
Large-scale deep learning identifies the antiviral potential of PKI-179 and MTI-31 against coronaviruses	21
Sulfated β-glucan from Agaricus subrufescens inhibits flavivirus infection and nonstructural protein 1-mediated pathogenesis	20
Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals	20
Avasimibe can cooperate with a DC-targeting and integration-deficient lentivector to induce stronger HBV specific T cytotoxic response by regulating cholesterol metabolism	20
Broad-spectrum antiviral activity of two structurally analogous CYP3A inhibitors against pathogenic human coronaviruses in vitro	20
Biological characterization of AB-343, a novel and potent SARS-CoV-2 Mpro inhibitor with pan-coronavirus activity	20
Performance of sofosbuvir and NITD008 in extrahepatic neuronal cells against HEV	20
Lung transcriptomics of K18-hACE2 mice highlights mechanisms and genes involved in the MVA-S vaccine-mediated immune response and protection against SARS-CoV-2 infection	19
Host factor DUSP5 potently inhibits dengue virus infection by modulating cytoskeleton rearrangement	19
Editorial Board	19
Eeyarestatin I, an inhibitor of the valosin-containing protein, exhibits potent virucidal activity against the flaviviruses	19

Antiviral effect of vesatolimod (GS-9620) against foot-and-mouth disease virus both in vitro and in vivo	19
Intranasal exposure to commensal bacterium Rothia mucilaginosa protects against influenza A virus infection	19
The diverse roles of peroxisomes in the interplay between viruses and mammalian cells	19
Elevated Soluble LAG-3 in Chronic Hepatitis B and T-Cell Responses to Checkpoint Blockade	19
Lipid-targeting antiviral strategies: Current state and future perspectives	18
Molecular mechanisms of hepatitis B virus entry inhibition by a bile acid derivative INT-767 binding to the preS1 region	18
LAVR-289, a broad-spectrum antiviral, protects immunosuppressed Syrian hamsters against lethal adenovirus challenge	18
A spatiotemporally controlled recombinant cccDNA mouse model for studying HBV and developing drugs against the virus	18
Astersaponin I from Aster koraiensis is a natural viral fusion blocker that inhibits the infection of SARS-CoV-2 variants and syncytium formation	17
HIV protease inhibitor attenuated astrocyte autophagy involvement in inflammation via p38 MAPK pathway	17
Development of a rapid image-based high-content imaging screening assay to evaluate therapeutic antibodies against the monkeypox virus	17
Interim analysis of the PARADISE study: Benefits of add-on peginterferon-α in NA-treated patients with CHB	17
Construction of a recombinant African swine fever virus with firefly luciferase and eGFP reporter genes and its application in high-throughput antiviral drug screening	17
Targeting PI4KB and Src/Abl host kinases as broad-spectrum antiviral strategy: Myth or real opportunity?	17
Structural and mechanistic insight into the phosphorylation reaction catalyzed by mpox virus thymidine kinase	17
Editorial Board	17
Virus infection and sphingolipid metabolism	17
Editorial Board	17
New technologies in therapeutic antibody development: The next frontier for treating infectious diseases	16
Antigenic mapping of enterovirus A71 from Taiwan and Southeast Asia	16
Porcine interferon-α linked to the porcine IgG-Fc induces prolonged and broad-spectrum antiviral effects against foot-and-mouth disease virus	16
Editorial Board	16
Development of a novel minigenome and recombinant VSV expressing Seoul hantavirus glycoprotein-based assays to identify anti-hantavirus therapeutics	16
The lack of HBsAg secretion does neither facilitate induction of antiviral T cell responses nor Hepatitis B Virus clearance in mice	16
Hemin protects against Zika virus infection by disrupting virus-endosome fusion	16
Induction of neutralizing antibodies and mucosal IgA through intranasal immunization with the receptor binding domain of SARS-CoV-2 spike protein fused with the type IIb E. coli heat-labile enterotoxi	16
Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants	16
RNA virus infections and their effect on host alternative splicing	16
Coronavirus nucleocapsid-based vaccine provides partial protection against hetero-species coronavirus in murine models	15
Identification of West Nile virus RNA-dependent RNA polymerase non-nucleoside inhibitors by real-time high throughput fluorescence screening	15
The host-targeted antiviral drug Zapnometinib exhibits a high barrier to the development of SARS-CoV-2 resistance	15
Deubiquitinase USP39 promotes SARS-CoV-2 replication by deubiquitinating and stabilizing the envelope protein	15
Targeting sgRNA N secondary structure as a way of inhibiting SARS-CoV-2 replication	15
Antiviral drug discovery with an optimized biochemical dengue protease assay: Improved predictive power for antiviral efficacy	15
Editorial Board	15
Cold-adapted influenza vaccine carrying three repeats of a respiratory syncytial virus (RSV) fusion glycoprotein epitope site protects BALB/c mice and cotton rats against RSV infection	15
GS-1 blocks entry of herpes viruses and more broadly inhibits enveloped viruses	15
Design and synthesis of a new series of hybrids of functionalised N1-[(1H-1,2,3-triazol-4-yl)methyl]quinazoline-2,4-dione with antiviral activity against Respiratory Syncytial Virus	15
Editorial Board	15
Editorial Board	15
Isochlorogenic acid A impairs hepatitis B virus replication by interference with various steps of hepatitis B virus life cycle involving HO-1-mediated ROS modulation	15
High-throughput drug screen identifies calcium and calmodulin inhibitors that reduce JCPyV infection	15
Identification of alpha-linolenic acid as a broad-spectrum antiviral against zika, dengue, herpes simplex, influenza virus and SARS-CoV-2 infection	15
History and impact of the mouse-adapted Ebola virus model	14
Three in one: An effective and universal vaccine expressing heterologous tandem RBD trimer by rabies virus vector protects mice against SARS-CoV-2	14
Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy	14
Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication	14
Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model	14
The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants	14
Antiviral strategies against human metapneumovirus: Targeting the fusion protein	14
Editorial Board	14
Salicylamide derivative JMX0312 protects immunosuppressed Syrian hamsters against adenovirus lethal challenge	14
Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication	14
CDK4/6 inhibitor palbociclib promotes SARS-CoV-2 cell entry by down-regulating SKP2 dependent ACE2 degradation	14
Retrospective analysis of steatosis effect on antiviral response and hepatocellular carcinoma risk in chronic hepatitis C	14
PRO-2000 exhibits SARS-CoV-2 antiviral activity by interfering with spike-heparin binding	14
Current and future use of antibody-based passive immunity to prevent or control HBV/HDV infections	14
Editorial Board	13
Editorial Board	13
Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants	13
Overview of gene editing strategies against HBV	13
Evaluation of panel of neutralising murine monoclonal antibodies and a humanised bispecific antibody against influenza A(H1N1)pdm09 virus infection in a mouse model	13
Nafamostat mesylate as a broad-spectrum candidate for the treatment of flavivirus infections by targeting envelope proteins	13
Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus	13
Insights on the antiviral mechanisms of action of the TLR1/2 agonist Pam3CSK4 in hepatitis B virus (HBV)-infected hepatocytes	13
Expanding the anti-flaviviral arsenal: Discovery of a baicalein-derived Compound with potent activity against DENV and ZIKV.	13
JC polyomavirus-encoded miRNA jcv-miR-J1-5p downregulates BK polyomavirus infection	13
Induction of antiviral gene expression by cyclosporine A, but not inhibition of cyclophilin A or B, contributes to its restriction of human coronavirus 229E infection in a lung epithelial cell line	13
25R,26-hydroxycholesterol and an oxysterol synthetic analog inhibit Varicella zoster Virus replication	13
Porcine epidemic diarrhea virus infection activates SREBP2 and induces RORγ expression to enhance cholesterol biosynthesis and virus replication	13
Substitutions M478K and A482G in the polymerase of yellow fever virus confer resistance to sofosbuvir and uprifosbuvir in vitro	12
Editorial Board	12
HDV sensing drives USP18-mediated refractoriness to IFN-α response, sparing IFN-β/λ in hepatocytes	12
Receptor recognition of hepatitis B and D viruses: Structural insight and its application to drug discovery	12
Marburg and Kasokero viruses elicit differential antiviral innate immune control by their natural reservoir bat, the Egyptian rousette (Rousettus aegyptiacus)	12
Exploiting host kinases to combat dengue virus infection and disease	12
Optimization of Bangladesh and Malaysian genotype recombinant reporter Nipah viruses for in vitro antiviral screening and in vivo disease modeling	12
Activation of cGAS-STING suppresses coxsackievirus replication via interferon-dependent signaling	12
Verteporfin is a broad-spectrum inhibitor of arboviruses and influences viral and host-based events	12
Antisense oligonucleotides as drugs with both direct and indirect antiviral actions	12

Influenza antivirals and their role in pandemic preparedness	12
A novel cellular tool for screening human pan-coronavirus antivirals	12
RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5ʹ-untranslated region	12
Mechanisms of action of repurposed Ebola virus antivirals – the roles of phospholipidosis and cholesterol homeostasis	12
Editorial Board	12
Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening	11
Discovery of broad-spectrum antivirals targeting viral proteases using in silico structural modeling and cellular analysis	11
Cathepsin inhibitors nitroxoline and its derivatives inhibit SARS-CoV-2 infection	11
Antiviral mechanisms and preclinical evaluation of amantadine analogs that continue to inhibit influenza A viruses with M2S31N-based drug resistance	11
Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome	11
Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains	11
Recombinant pseudorabies virus (PRV) expressing stabilized E2 of classical swine fever virus (CSFV) protects against both PRV and CSFV	11
Effect of E23G/K, F36V, N37T, E119D, and E199G polymerase acidic protein substitutions on the replication and baloxavir susceptibility of influenza B viruses	11
β-d-N4-hydroxycytidine, a metabolite of molnupiravir, exhibits in vitro antiviral activity against rabies virus	11
Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus	11
Screening of an epigenetic compound library identifies BRD4 as a potential antiviral target for hepatitis B virus covalently closed circular DNA transcription	11
Evaluation of pharmacokinetics of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil (TDF) in pregnant and postpartum women in South Africa: PrEP-PP PK study	11
Dynamic features of virus protein 1 and substitutions in the 3-phenyl ring determine the potency and broad-spectrum activity of capsid-binding pyrazolo[3,4-d]pyrimidines against rhinoviruses	11
Effect of antivirals on clinical and lab-adapted human cytomegalovirus strains using induced pluripotent stem cell-derived human neural models	11
The calcium channel inhibitor lacidipine inhibits Zika virus replication in neural progenitor cells	11
Inhibitors of pyrimidine synthesis synergize with N4-hydroxycytidine to diminish influenza virus replication	11
Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus	11
Small molecule direct-acting antivirals for treatment of mpox	10
Identification of claramine and anidulafungin as entry inhibitors of Crimean–Congo hemorrhagic fever virus	10
Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro	10
Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication	10
Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: Blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the vira	10
Lapachol, a dihydroorotate dehydrogenase inhibitor, demonstrates antiviral activity against feline calicivirus in vitro and in vivo	10
Characterization of SARS-CoV-2 replication in human H1299/ACE2 cells: A versatile and practical infection model for antiviral research and beyond	10
Characterization of clinical envelopes with lack of sensitivity to the HIV-1 inhibitors temsavir and ibalizumab	10
Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate	10
A bivalent form of a RBD-specific synthetic antibody effectively neutralizes SARS-CoV-2 variants	10
Tissue replication and mucosal swab detection of Sosuga virus in Syrian hamsters in the absence of overt tissue pathology and clinical disease	10
Pathogenicity and antiviral treatment of clade Ib Monkeypox virus infection in mice	10
Preclinical efficacy of a favipiravir and nitazoxanide combination against Rift Valley Fever Virus	10
A potent neutralizing and protective antibody against a conserved continuous epitope on HSV glycoprotein D	10
New insights into the neuraminidase-mediated hemagglutination activity of influenza A(H3N2) viruses	10
β-D-N4-hydroxycytidine (NHC, EIDD-1931) inhibits chikungunya virus replication in mosquito cells and ex vivo Aedes aegypti guts, but not when ingested during blood-feeding	10
α7 nicotinic receptor activation mitigates herpes simplex virus type 1 infection in microglia cells	10
Vemurafenib inhibits the replication of diabetogenic enteroviruses in intestinal epithelial and pancreatic beta cells	10
Pinostrobin from plants and propolis against human coronavirus HCoV-OC43 by modulating host AHR/CYP1A1 pathway and lipid metabolism	10
Functional assessments of SARS-CoV-2 single-round infectious particles with variant-specific spike proteins on infectivity, drug sensitivity, and antibody neutralization	10
Low antiviral resistance in Influenza A and B viruses isolated in Mexico from 2010 to 2023	10
Editorial Board	10
Viral sequence analysis of chronic hepatitis B patients treated with the capsid assembly modulator JNJ-56136379 in the JADE phase 2a study	10
Cyclic lipopeptides as membrane fusion inhibitors against SARS-CoV-2: New tricks for old dogs	10
Anti-SARS-CoV-2 gapmer antisense oligonucleotides targeting the main protease region of viral RNA	10
Editorial Board	10
Assessing the chronic hepatitis B adaptive immune response by profiling specific T-cell receptor repertoire	10
KDM5A/B contribute to HIV-1 latent infection and survival of HIV-1 infected cells	10
Assessment of CMV infection in allo-HSCT recipients undergoing LMV prophylaxis by using an implemented diagnostic protocol to identify active viral replication	10
The ApoA1-mimetic peptide 4F blocks flavivirus NS1-triggered endothelial dysfunction and protects against lethal dengue virus challenge	10
Cholesterol 25-hydroxylase inhibits Newcastle disease virus replication by its architectural damage and blocking HN protein	10
5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro	10
Evaluation of a novel severe combined immunodeficiency mouse model for antiviral drug evaluation against Chandipura virus infection	10
Targeting of the cellular ATM rather than ATR kinase exhibits therapeutic potential during the lumpy skin disease virus infection in vivo and in vitro	10
Identification of oxysterol synthetic analogs as a novel class of late-stage inhibitors of herpes simplex virus 2 replication	10