Trends in Neurosciences

Article	Citations
The Brain’s Glymphatic System: Current Controversies	313
The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self	264
Neurodevelopmental Disorders: From Genetics to Functional Pathways	248
Effects of Exercise on Brain and Cognition Across Age Groups and Health States	174
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System	157
Neural Circuits of Interoception	149
Where is Cingulate Cortex? A Cross-Species View	144
Astrocytic processes: from tripartite synapses to the active milieu	127
The Effects of Age-Related Hearing Loss on the Brain and Cognitive Function	126
Functions of Interoception: From Energy Regulation to Experience of the Self	124
Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans	123
Signaling by cGAS–STING in Neurodegeneration, Neuroinflammation, and Aging	121
Mitochondria and Calcium in Alzheimer’s Disease: From Cell Signaling to Neuronal Cell Death	116
Blood–Brain Barrier Dynamics to Maintain Brain Homeostasis	116
The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2	115
A Unifying Account of Angular Gyrus Contributions to Episodic and Semantic Cognition	113
Diseases, Disorders, and Comorbidities of Interoception	111
Immunometabolism in the Brain: How Metabolism Shapes Microglial Function	108
Cellular senescence at the crossroads of inflammation and Alzheimer's disease	107
Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer’s Disease Genetics	104
Circuit organization of the rodent medial prefrontal cortex	101
Prenatal Origins of ASD: The When, What, and How of ASD Development	99
Computational Models of Interoception and Body Regulation	98
Is COVID-19 a Perfect Storm for Parkinson’s Disease?	96
Movement-Related Signals in Sensory Areas: Roles in Natural Behavior	96

Magnetoencephalography with optically pumped magnetometers (OPM-MEG): the next generation of functional neuroimaging	93
Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure	91
Interventions and Manipulations of Interoception	90
How Do Sensory Neurons Sense Danger Signals?	86
Hippocampal contributions to social and cognitive deficits in autism spectrum disorder	84
Spinal Muscular Atrophy: In the Challenge Lies a Solution	84
Neurodevelopmental Optimization after Early-Life Adversity: Cross-Species Studies to Elucidate Sensitive Periods and Brain Mechanisms to Inform Early Intervention	82
The Paradox of HIV Blood–Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies	80
How critical is brain criticality?	79
A Multi-Brain Framework for Social Interaction	77
16p11.2 Copy Number Variations and Neurodevelopmental Disorders	75
Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina	74
Social Cognition in the Age of Human–Robot Interaction	74
Cause or consequence? Alpha oscillations in visuospatial attention	70
Pupillometry as an integrated readout of distinct attentional networks	66
Functional interplay between central and autonomic nervous systems in human fear conditioning	64
Principles of Corticocortical Communication: Proposed Schemes and Design Considerations	64
Synthesizing Views to Understand Sex Differences in Response to Early Life Adversity	63
Tapping into Multi-Faceted Human Behavior and Psychopathology Using fMRI Brain Dynamics	63
Glucocorticoids as Mediators of Adverse Outcomes of Prenatal Stress	62
The Gut–CNS Axis in Multiple Sclerosis	60
A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease	59
Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis	59
Transforming the Concept of Memory Reactivation	59
Basal Progenitor Morphology and Neocortex Evolution	58
The Distributed Nociceptive System: A Framework for Understanding Pain	58
A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics	58
The Multifaceted Roles of KCC2 in Cortical Development	57
Microglia in Cancer Therapy-Related Cognitive Impairment	56
Lysosomal dysfunction in neurodegeneration: emerging concepts and methods	56
The many dimensions of human hippocampal organization and (dys)function	56
Narratives for Neuroscience	55
Resurrecting the Mysteries of Big Tau	54
LRRK2 and idiopathic Parkinson’s disease	53
The quest for multiscale brain modeling	52
Extracellular Vesicles as an Emerging Frontier in Spinal Cord Injury Pathobiology and Therapy	52
Neurobiology of the lateral septum: regulation of social behavior	52
How Outcome Uncertainty Mediates Attention, Learning, and Decision-Making	51
The use of language in autism research	51
Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System	51
Getting in Touch with Mechanical Pain Mechanisms	50
Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis	49
Circular RNAs: The Brain Transcriptome Comes Full Circle	48
The paraventricular nucleus of the thalamus: an integrative node underlying homeostatic behavior	47
Closing in on Mechanisms of Open Neural Tube Defects	46
Autophagy in Neuronal Development and Plasticity	46
Dopamine ‘ups and downs’ in addiction revisited	46
Neurovascular coupling: motive unknown	46
The Tail of the Striatum: From Anatomy to Connectivity and Function	44
Calcium-dependent docking of synaptic vesicles	43

Brain cell type-specific cholesterol metabolism and implications for learning and memory	43
Connecting TDP-43 Pathology with Neuropathy	42
Quiescent Neural Stem Cells for Brain Repair and Regeneration: Lessons from Model Systems	42
Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases	42
How cancer hijacks the body’s homeostasis through the neuroendocrine system	42
50 years of mnemonic persistent activity: quo vadis?	42
Noisy Synaptic Conductance: Bug or a Feature?	41
Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms	41
Extracellular Vesicle-Mediated Bilateral Communication between Glioblastoma and Astrocytes	40
Distributional Reinforcement Learning in the Brain	40
The Role of Astrocytes in Remyelination	40
Astrocyte and neuron cooperation in long-term depression	40
Macrophages on the margin: choroid plexus immune responses	39
Going beyond primary motor cortex to improve brain–computer interfaces	38
Entorhinal cortex dysfunction in Alzheimer's disease	37
Interbrain synchrony: on wavy ground	36
RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain	36
Post-translational Modifications of Opioid Receptors	36
Cortical disinhibitory circuits: cell types, connectivity and function	36
Walking with Salamanders: From Molecules to Biorobotics	36
Local cholesterol metabolism orchestrates remyelination	35
Regulation of GABAARs by Transmembrane Accessory Proteins	35
Mitochondrial dysfunction as a trigger of programmed axon death	33
Insulin action in the brain: cell types, circuits, and diseases	33
Do Nicotinic Receptors Modulate High-Order Cognitive Processing?	32
Using artificial neural networks to ask ‘why’ questions of minds and brains	32
Kalirin and Trio: RhoGEFs in Synaptic Transmission, Plasticity, and Complex Brain Disorders	32
Circuit-Based Biomarkers for Mood and Anxiety Disorders	32
The foundation and architecture of precision medicine in neurology and psychiatry	31
Beneficial and detrimental functions of microglia during viral encephalitis	31
Translational approaches to understanding resilience to Alzheimer’s disease	31
To look or not to look: dissociating presaccadic and covert spatial attention	31
Neural consequences of chronic sleep disruption	31
The emerging association between COVID-19 and acute stroke	30
Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy	30
Mitochondrial signalling and homeostasis: from cell biology to neurological disease	30
The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration	30
Impacts of Sleep Loss versus Waking Experience on Brain Plasticity: Parallel or Orthogonal?	30
Where is the error? Hierarchical predictive coding through dendritic error computation	30
Deep learning and the Global Workspace Theory	29
VPS10P Domain Receptors: Sorting Out Brain Health and Disease	29
Proteostatic regulation in neuronal compartments	29
Watch and Learn: The Cognitive Neuroscience of Learning from Others’ Actions	29
Mechanical Forces Orchestrate Brain Development	29
Resolving the Synaptic versus Developmental Dichotomy of Autism Risk Genes	29
Intercellular Communication in the Nervous System Goes Viral	28
Alcohol and the brain: from genes to circuits	28
Peripheral Innervation in the Regulation of Glucose Homeostasis	28
Hypothalamic Interactions with Large-Scale Neural Circuits Underlying Reinforcement Learning and Motivated Behavior	28
Drosophila Mechanosensory Transduction	27
Shedding Light on Chandelier Cell Development, Connectivity, and Contribution to Neural Disorders	27
Neural basis of prosocial behavior	26
Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown	26
α-Synuclein in synaptic function and dysfunction	26
Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders	26
Deep entorhinal cortex: from circuit organization to spatial cognition and memory	26
Mechanistic flexibility of the retrosplenial cortex enables its contribution to spatial cognition	25
Interferon γ: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration	25
Mitochondria: new players in homeostatic regulation of firing rate set points	25
A predictive coding framework of allostatic–interoceptive overload in frontotemporal dementia	24
The iPSC perspective on schizophrenia	24
How Early Life Adversity Influences Defensive Circuitry	24
Understanding Vulnerability and Adaptation in Early Brain Development using Network Neuroscience	24
Polar angle asymmetries in visual perception and neural architecture	24
An Emerging Role for Prolactin in Female-Selective Pain	24
A Network Perspective on Sensorimotor Learning	23
Oxidized phospholipids as novel mediators of neurodegeneration	22
Condensate biology of synaptic vesicle clusters	22
Little cells of the little brain: microglia in cerebellar development and function	22
Orexin (hypocretin) and addiction	22
Surface-based hippocampal subfield segmentation	22
α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity	22
The Evolution-Driven Signature of Parkinson’s Disease	22
Rethinking stress resilience	21
A Circuit-Based Information Approach to Substance Abuse Research	21
Cognition through the lens of a body–brain dynamic system	21
Why is everyone talking about brain state?	21
How Bacteria Impact Host Nervous System and Behaviors: Lessons from Flies and Worms	21
White Matter Microstructure across the Psychosis Spectrum	21
Disabled in academia: to be or not to be, that is the question	21

Spinal ascending pathways for somatosensory information processing	20
The Raphe Dopamine System: Roles in Salience Encoding, Memory Expression, and Addiction	20
Learning offline: memory replay in biological and artificial reinforcement learning	20
Malnutrition and the microbiome as modifiers of early neurodevelopment	19
PET Imaging as a Tool for Assessing COVID-19 Brain Changes	19
Informing deep neural networks by multiscale principles of neuromodulatory systems	19
PTEN mutations in autism spectrum disorder and congenital hydrocephalus: developmental pleiotropy and therapeutic targets	19
Reinforcement learning detuned in addiction: integrative and translational approaches	18
A call for more clarity around causality in neuroscience	18
Neuroinflammation associated with ultrasound-mediated permeabilization of the blood–brain barrier	18
Neurofeedback through the lens of reinforcement learning	18
Neurobiology of brain oscillations in acute and chronic pain	18
Foundations and implications of astrocyte heterogeneity during brain development and disease	17
Bidirectional Brain-Systemic Interactions and Outcomes After TBI	17
Circadian clock, diurnal glucose metabolic rhythm, and dawn phenomenon	17
How the immune system shapes neurodegenerative diseases	17
Construction of complex memories via parallel distributed cortical–subcortical iterative integration	17
Regulation of circuit organization and function through inhibitory synaptic plasticity	17
Induced pluripotent stem cells: a tool for modeling Parkinson’s disease	17
How do protein aggregates escape quality control in neurodegeneration?	17
Harmony Lost: Cell–Cell Communication at the Neuromuscular Junction in Motor Neuron Disease	17
Neuroprotective versus Neuroinflammatory Roles of Complement: From Development to Disease	16
Dynamic coupling of oscillatory neural activity and its roles in visual attention	15
Insights and opportunities for deep brain stimulation as a brain circuit intervention	15
MicroRNA regulation of critical retinal pigment epithelial functions	15
SARS-CoV-2-specific neuropathology: fact or fiction?	15
The dorsal raphe nucleus in the control of energy balance	14
Persistent nociceptor hyperactivity as a painful evolutionary adaptation	14
Subtypes of Alzheimer’s disease: questions, controversy, and meaning	14
Contributions by metaplasticity to solving the Catastrophic Forgetting Problem	13
Spatiotemporally resolved protein synthesis as a molecular framework for memory consolidation	13
TDP-43 Puts the STING in ALS	13
Unraveling the dynamics of dopamine release and its actions on target cells	13
Prefrontal cortex as a key node in arousal circuitry	13
Neuronal Maturation: Challenges and Opportunities in a Nascent Field	13
Poststroke arm and hand paresis: should we target the cervical spinal cord?	12
Toward a neurobiology of internal selective attention	12
Transitions in Brain Evolution: Space, Time and Entropy	12
Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer’s disease	12
The structure of cyclic nucleotide-gated channels in rod and cone photoreceptors	11
Evaluating microglial phenotypes using single-cell technologies	11
Cancer as a homeostatic challenge: the role of the hypothalamus	11
The impact of stress on the hippocampal spatial code	11
Whole-head OPM-MEG enables noninvasive assessment of functional connectivity	11
Probing mechanisms of visual spatial attention in mice	11
The Age-Dependent Neural Substrates of Blindsight	11
Bridging the big (data) gap: levels of control in small- and large-scale cognitive neuroscience research	11
Beyond sex differences: short- and long-term effects of pregnancy on the brain	10
Emerging approaches for decoding neuropeptide transmission	10
What can we learn from inactivation studies? Lessons from auditory cortex	10
Calming Neurons with a Microglial Touch	9
Useful misrepresentation: perception as embodied proactive inference	9
Birdsong neuroscience and the evolutionary substrates of learned vocalization	9
The tricky business of defining brain functions	9
Reassessing neurodegenerative disease: immune protection pathways and antagonistic pleiotropy	9
Atomic Structures of Amyloid-β Oligomers Illuminate a Neurotoxic Mechanism	9
Synergistic effects of brain injury and aging: common mechanisms of proteostatic dysfunction	9
Inflammasome assembly in neurodegenerative diseases	9
The common marmoset as a model of neurodegeneration	9
Large-scale, closed-loop interrogation of neural circuits underlying cognition	9
Consider the pons: bridging the gap on sensory prediction abnormalities in schizophrenia	8
Mental navigation and the neural mechanisms of insight	8
The neuroscience of music – towards ecological validity	8
Autophagy Pathways in CNS Myeloid Cell Immune Functions	8
Neurovascular adaptations modulating cognition, mood, and stress responses	8
Control of energy homeostasis by the lateral hypothalamic area	8
Probing top-down information in neocortical layer 1	8
Astrocytes: integrators of arousal state and sensory context	8
Microglial diversity in neuropathic pain	8
Emerging roles of oligodendrocyte precursor cells in neural circuit development and remodeling	8
Intercellular signaling by ectodomain shedding at the synapse	8
Transposable elements and Alzheimer’s disease pathogenesis	7
Alterations in pain during adolescence and puberty	7
Control of lymph node activity by direct local innervation	7
Pathological potential of oligodendrocyte precursor cells: terra incognita	7
High-resolution optogenetics in space and time	7
Anterior to Posterior Whole-Brain Gradient for Different Types of Memories?	7
Alternative Frameworks for Advancing the Study of Eating Disorders	7
The Jekyll and Hyde of TREM2	7
Ocular and extraocular roles of neuropsin in vertebrates	7
Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity	7
Links between the brain and body during sleep: implications for memory processing	7
Crossmodal plasticity in hearing loss	7
Retinal receptive-field substructure: scaffolding for coding and computation	7
Neuronal pericellular baskets: neurotransmitter convergence and regulation of network excitability	7
Genetic insights into the neurobiology of anxiety	6
Ctenophores and the evolutionary origin(s) of neurons	6
Altered stress granule disassembly: links to neurodegenerative disease?	6
Continuously changing memories: a framework for proactive and non-linear consolidation	6
Continual task learning in natural and artificial agents	6
Maladaptive explore/exploit trade-offs in schizophrenia	6
T cells direct microglial repair of white matter after stroke	6
Understanding the aging hypothalamus, one cell at a time	6
Distinct globus pallidus circuits regulate motor and cognitive functions	6
A critical period plasticity framework for the sensorimotor–association axis of cortical neurodevelopment	6